Affinage

IL13RA1

Interleukin-13 receptor subunit alpha-1 · UniProt P78552

Length
427 aa
Mass
48.8 kDa
Annotated
2026-04-28
86 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL13RA1 encodes the signal-transducing subunit of the type II IL-4 receptor, heterodimerizing with IL-4Rα to form the principal receptor for IL-13 and a co-receptor for IL-4, thereby activating JAK-STAT6 and p38 MAPK signaling across immune, epithelial, neuronal, and mesenchymal cell types (PMID:8552669, PMID:18066066, PMID:40198135). In the immune system, IL-13Rα1 on non-hematopoietic cells is required for allergen-induced airway hyperreactivity, eosinophilic esophagitis, and atopic dermatitis, while on enteric sensory neurons it amplifies neuropeptide (NMU, CGRPβ) expression essential for anti-helminth defense (PMID:32060143, PMID:36070083, PMID:40403128). Beyond classical type 2 immunity, IL-13Rα1 functions as a synaptic protein modulating NMDAR/AMPAR phosphorylation and neuroprotection, drives beige adipogenesis through STAT6-dependent PPARγ induction in preadipocytes, sustains intestinal stem cell self-renewal via Foxp1–β-catenin signaling, and is selectively essential for Hodgkin lymphoma cell survival (PMID:36639371, PMID:40198135, PMID:30643264, PMID:41422061). Receptor surface expression is post-transcriptionally tuned by IGF2BP3-mediated mRNA destabilization and by a primate-specific dominant-negative splice isoform (IL-13Rα1-LOR1a) that attenuates type 2 cytokine responsiveness (PMID:40614216).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1996 High

    Identification of IL-13Rα1 as the low-affinity IL-13 binding chain that, upon expression, generates high-affinity IL-13 receptors and cross-reacts with IL-4 binding established it as the shared signal-transducing subunit for both cytokines.

    Evidence Transient/stable transfection in COS-7 and CTLL-2 cells with binding and proliferation assays

    PMID:8552669

    Open questions at the time
    • Heterodimerization partner (IL-4Rα) not yet formally demonstrated
    • Downstream signaling cascade uncharacterized
  2. 2000 Medium

    Genomic characterization revealed conserved cytokine receptor motifs (WSxWS, Box1), X-chromosomal linkage, and alternative splicing generating soluble isoforms, providing the structural framework for understanding IL-13Rα1 signaling and its sex-linked expression.

    Evidence Genomic cloning, interspecific backcross mapping, RT-PCR in mouse

    PMID:11003391

    Open questions at the time
    • Functional significance of soluble isoforms not tested
    • No structural data for receptor–ligand complex
  3. 2007 High

    Genetic ablation of Il13ra1 in mice proved that IL-13Rα1 is indispensable for type II IL-4R formation and demonstrated non-redundant in vivo roles: required for allergen-induced airway disease but dispensable for alternative macrophage activation, resolving the functional divergence of type I vs. type II IL-4 receptors.

    Evidence Il13ra1−/− mice challenged with allergens, S. mansoni, and N. brasiliensis

    PMID:18066066

    Open questions at the time
    • Cell-type-specific contributions not dissected (no conditional KO)
    • Downstream transcriptional programs not defined
  4. 2012 High

    Discovery that IL-13Rα1 is expressed on dopaminergic neurons and mediates their oxidative stress susceptibility extended the receptor's function beyond the immune system into neurodegeneration.

    Evidence Immunohistochemistry, Il13ra1−/− mice with LPS challenge, cytotoxicity assays in MN9D cells

    PMID:23169588

    Open questions at the time
    • Whether neuronal IL-13Rα1 signals through canonical STAT6 not shown
    • Human genetic relevance not established at this point
  5. 2015 Medium

    The finding that Il13ra1 deficiency exacerbated bleomycin-induced lung fibrosis—independently of IL-13, IL-4, or IL-13Rα2—revealed an unexpected homeostatic/protective function for IL-13Rα1 in lung epithelium.

    Evidence Il13ra1−/− mice, bleomycin model, bone marrow chimeras, epistasis with multiple cytokine KOs

    PMID:26153764

    Open questions at the time
    • The ligand or pathway mediating the protective effect remains unidentified
    • Single lab, not independently replicated
  6. 2017 Medium

    Parallel studies showed IL-13Rα1 deficiency causes cardiac dysfunction with reduced collagen deposition, and accelerates stress-induced dopaminergic neuron loss, broadening the receptor's tissue-specific roles to heart and brain homeostasis.

    Evidence Il13ra1−/− mice with echocardiography (cardiac) and chronic restraint stress model (neuronal)

    PMID:28427412 PMID:28528324

    Open questions at the time
    • Cardiac signaling pathway downstream of IL-13Rα1 undefined
    • Stress-induced neuronal loss delayed but not abolished—extent of receptor dependency unclear
  7. 2019 High

    Demonstration that circPan3 stabilizes Il13ra1 mRNA in intestinal stem cells, enabling IL-13–IL-13Rα1 signaling to induce Foxp1 and activate β-catenin for self-renewal, placed IL-13Rα1 at the nexus of niche cytokine signaling and stem cell maintenance.

    Evidence circPan3 deletion in Lgr5+ ISCs, organoid culture, RNA binding assays, gut regeneration assays

    PMID:30643264

    Open questions at the time
    • Whether this circPan3–IL-13Rα1 axis operates in human intestinal stem cells not tested
    • Direct STAT6 involvement in ISC self-renewal not shown
  8. 2020 High

    Bone marrow chimera and conditional approaches in atopic dermatitis models established that IL-13Rα1 on non-hematopoietic cells (keratinocytes) is the critical mediator of IL-13-driven dermatitis, while gain-of-function IL13RA1 variants in Parkinson's patients increased neuronal oxidative cytotoxicity, linking the receptor to disease genetics.

    Evidence Il13ra1−/− chimeras and antibody blockade in AD models; variant proteins tested in SH-SY5Y neurons with oxidative stressors

    PMID:32060143 PMID:32276028

    Open questions at the time
    • Gain-of-function PD variants not validated in animal models
    • Structural basis for increased cytotoxicity of L→F variant unknown
  9. 2022 High

    Epithelial-specific Il13ra1 deletion (Krt14Cre) fully protected mice from experimental eosinophilic esophagitis, and scRNA-seq of human EoE biopsies confirmed epithelial IL-13Rα1 as the disease-driving receptor, providing the strongest cell-type-specific causal evidence for IL-13Rα1 in allergic epithelial disease.

    Evidence Conditional Krt14Cre Il13ra1 KO mice, experimental EoE, human scRNA-seq

    PMID:36070083

    Open questions at the time
    • Downstream epithelial transcriptional program mediating EoE pathology not fully delineated
    • No therapeutic intervention targeting IL-13Rα1 directly tested
  10. 2023 High

    Identification of IL-13Rα1 as a synaptic protein that, upon IL-13 engagement, increases NMDAR/AMPAR phosphorylation and protects neurons from excitotoxicity redefined the receptor as a neuromodulatory signaling hub, validated across species and in human TBI patients.

    Evidence Synaptic fractionation, phosphorylation assays, excitotoxicity models, human CSF/brain analysis

    PMID:36639371

    Open questions at the time
    • Signal transduction intermediates between IL-13Rα1 and glutamate receptor phosphorylation uncharacterized
    • Whether neuroprotection requires JAK-STAT or alternative pathway unknown
  11. 2025 High

    Multiple 2025 studies completed the mechanistic picture: IL-13Rα1 on preadipocytes drives beige adipogenesis via STAT6–PPARγ and p38 MAPK; on enteric sensory neurons it amplifies NMU/CGRPβ for anti-helminth defense; a primate-specific dominant-negative isoform (LOR1a) fine-tunes receptor output; IGF2BP3 post-transcriptionally destabilizes IL13RA1 mRNA; and genome-wide CRISPR screens identified IL13RA1 as selectively essential for Hodgkin lymphoma survival.

    Evidence Preadipocyte-specific KO with metabolic phenotyping; PSN-specific KO with helminth challenge; isoform reconstitution and signaling assays; IGF2BP3 RIP and mRNA stability assays; CRISPR screens across >1000 cancer lines with antibody blockade

    PMID:40198135 PMID:40403128 PMID:40614216 PMID:41422061

    Open questions at the time
    • Physiological ratio of LOR1a to canonical isoform across human tissues unknown
    • Whether IGF2BP3-mediated regulation operates in non-epithelial cell types untested
    • Structural basis for constitutive JAK-STAT activation by overexpressed IL-13Rα1 in lymphoma undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis for IL-13Rα1 signaling at synapses versus immune cells; identity of the ligand/pathway mediating IL-13Rα1's ligand-independent lung-protective function; and whether targeting IL-13Rα1 therapeutically (rather than its ligands) is effective in EoE, AD, or Hodgkin lymphoma.
  • No crystal structure of human IL-13Rα1 in complex with IL-4Rα
  • Neuronal signaling intermediates downstream of synaptic IL-13Rα1 uncharacterized
  • Therapeutic antibodies directly targeting IL-13Rα1 (distinct from IL-4Rα or IL-13) not clinically evaluated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 5 GO:0005576 extracellular region 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-168256 Immune System 4 R-HSA-1643685 Disease 3 R-HSA-1266738 Developmental Biology 2 R-HSA-112316 Neuronal System 1
Partners
FOXP1IGF2BP3IL13IL4IL4RSTAT6
Complex memberships
Type II IL-4 receptor (IL-4Rα/IL-13Rα1)

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 IL-13Rα1 (NR4/murine) was identified as the primary low-affinity IL-13 binding subunit of the IL-13 receptor; stable expression in CTLL-2 cells generated high-affinity IL-13 receptors capable of transducing a proliferative signal and also led to competitive cross-reactivity with IL-4 binding, establishing IL-13Rα1 as a shared component of IL-4 and IL-13 receptor complexes. Transient expression in COS-7 cells, stable transfection in CTLL-2 cells, binding assays, proliferation assay Proceedings of the National Academy of Sciences of the United States of America High 8552669
2000 The mouse Il13ra1 gene spans ~56 kb with 11 exons and shows conserved cytokine receptor family motifs (conserved cysteines, WSxWS motif, Box1); alternative mRNA splicing generates soluble IL-13Rα1 isoforms; Il13ra1 maps to the proximal mouse X chromosome and is co-expressed with Il4ra in myeloid and NK cells, confirming IL-13Rα1 as the major signaling component of the IL-13 receptor complex in lymphohematopoietic cells. Genomic cloning, interspecific backcross mapping, RT-PCR, alternative splicing analysis Immunogenetics Medium 11003391
2007 Using Il13ra1-/- mice, IL-13Rα1 was shown to be essential for formation of the type II IL-4 receptor (IL-4Rα/IL-13Rα1 heterodimer); loss of IL-13Rα1 exacerbated Th2 responses (distinct from Il4ra-/- mice which weaken Th2 responses), was required for allergen-induced airway hyperreactivity and mucus hypersecretion, but was dispensable for fibroblast or alternative macrophage activation, demonstrating functionally distinct roles of type I vs. type II IL-4 receptors in vivo. Il13ra1-/- mouse genetic knockout, infection models (S. mansoni, N. brasiliensis), allergen challenge, cytokine and cellular readouts Nature immunology High 18066066
2012 IL-13Rα1 is expressed on dopaminergic (DA) neurons of the substantia nigra pars compacta; Il13ra1-deficient mice were resistant to LPS-induced loss of DA neurons; IL-13 and IL-4 potentiated oxidative cytotoxicity (t-butyl hydroperoxide, H2O2) on DA MN9D cells, indicating that IL-13Rα1 expression increases DA neuron susceptibility to oxidative stress-mediated damage. Immunohistochemistry for receptor localization, Il13ra1-/- mouse KO, chronic peripheral LPS inflammation model, in vitro cytotoxicity assay on MN9D cells Journal of immunology (Baltimore, Md. : 1950) High 23169588
2017 IL-13Rα1 deficiency in mice leads to severe myocardial dysfunction and dyssynchrony (reduced ejection fraction, increased end-diastolic diameter) and reduced collagen deposition under normal and pressure-overload conditions, indicating a role for IL-13Rα1/type II IL-4R signaling in myocardial homeostasis and extracellular matrix regulation. Il13ra1-/- mouse KO, echocardiography, bioinformatic transcriptome analysis of mouse hearts, histology Journal of the American Heart Association Medium 28528324
2017 IL-13Rα1 is expressed in microglial cells within the substantia nigra and in a fraction of tyrosine hydroxylase-positive DA neurons; IL-13 levels are elevated by chronic restraint stress; lack of IL-13Rα1 delayed (but did not prevent) stress-induced loss of DA neurons, confirming a role for IL-13/IL-13Rα1 signaling in accelerating stress-dependent DA neuron vulnerability. Immunofluorescence, in situ hybridization, Il13ra1 Y/- knockout mice, chronic restraint stress model, neuron counting Journal of neuroinflammation Medium 28427412
2019 circPan3 RNA binds Il13ra1 mRNA in Lgr5+ intestinal stem cells (ISCs) to increase its stability, leading to surface expression of IL-13Rα1 in ISCs; IL-13 produced by ILC2s in the crypt niche engages IL-13Rα1 on ISCs, activating IL-13–IL-13R signaling that initiates Foxp1 expression, which associates with β-catenin to promote its nuclear translocation and activate the β-catenin pathway for ISC self-renewal. circPan3 deletion in Lgr5+ ISCs, RNA binding assays, ISC organoid culture, gut regeneration assays, signaling pathway analysis Nature immunology High 30643264
2020 In experimental atopic dermatitis models in Il13ra1-/- mice (lacking type II IL-4R), IL-13 signaling via IL-13Rα1 on non-hematopoietic cells was required for dermatitis, TNF-α, CXCL1, and CCL11 expression; bone marrow chimera studies dissected hematopoietic vs. non-hematopoietic contributions; IL-4 signaling via type I IL-4R on hematopoietic cells controlled IgE, CCL24, and skin eosinophilia. Il13ra1-/- mouse KO, two AD models, bone marrow chimeric mice, cytokine neutralization, pharmacological IL-13Rα1 targeting Science immunology High 32060143
2020 Two rare missense SNPs — rs148077750 (IL-13 L→P) and rs145868092 (IL-13Rα1 L→F at a residue critical for IL-13 binding) — identified in individuals with early-onset Parkinson's disease increased the cytotoxic activity of IL-13 on human SH-SY5Y neurons exposed to oxidative stressors (H2O2, t-butyl hydroperoxide, RSL3/ferroptosis inducer), constituting gain-of-function mutations in the IL-13/IL-13Rα1 oxidative stress pathway. Genetic association analysis, in vitro cytotoxicity assay with variant proteins in SH-SY5Y cells Brain, behavior, and immunity Medium 32276028
2022 IL-13 signaling via IL-13Rα1 in esophageal epithelial cells is required for eosinophilic esophagitis (EoE): Il13ra1-/- mice and mice with epithelial-specific Il13ra1 deletion (Krt14Cre/Il13ra1fl/fl) were protected from experimental EoE; single-cell RNA sequencing of human EoE confirmed predominant IL-13Rα1 expression in epithelial cells and correlation of EoE signature genes with IL-13 rather than IL-4. Whole-body and conditional (Krt14Cre) Il13ra1-/- mouse KO, experimental EoE induction, histopathology, RNA-seq, scRNA-seq of human biopsies Allergy High 36070083
2023 IL-13 and IL-13Rα1 are expressed as synaptic proteins in mouse, rat, and human neurons; IL-13 engagement of IL-13Rα1 at synapses upregulates phosphorylation of NMDAR and AMPAR subunits, increases synaptic activity and CREB-mediated transcription; IL-13 upregulation protects neurons from excitotoxic death and is elevated after traumatic brain injury in mice and human patients. Immunolocalization, synaptic fractionation, phosphorylation assays, in vitro excitotoxicity assay, TBI mouse models, human CSF/brain sample analysis Nature communications High 36639371
2023 IL-4/IL-13 activate the type II IL-4Rα/IL-13Rα1 receptor in keratinocytes to induce IL-2Rγ expression; this induction requires IL-13Rα1 signaling (absent in IL13RA1 KO reconstructed human epidermis) and is blocked by JAK inhibitors; IL-2Rγ in turn contributes to epidermal barrier disruption and regulates IL-13Rα2 expression. Reconstructed human epidermis (RHE) KO for IL13RA1 and IL2RG, JAK inhibitor treatment, mRNA/protein expression assays, AD skin immunostaining Experimental dermatology Medium 36645024
2024 IL13RA1 on the inactive X chromosome undergoes epigenetic reactivation in female primary mediastinal large B-cell lymphoma (PMBCL); overexpressed IL-13Rα1 in Ba/F3 cells transforms murine pro-B cells and constitutively activates JAK-STAT signaling, identifying IL-13Rα1 overexpression as an oncogenic driver in PMBCL. Molecular cytogenetics (FISH), RNAseq, immunohistochemistry, in vitro Ba/F3 cell transformation assay, JAK-STAT signaling readout HemaSphere Medium 41017961
2025 IL-13 signals through IL-13Rα1 (IL-13R1) in preadipocytes to drive beige adipogenesis; downstream effectors are STAT6 (increasing PPARγ expression) and p38 MAPK (increasing PPARγ activity); preadipocyte-specific Il13ra1-KO mice were refractory to cold- or β3-adrenergic agonist-induced beiging, showed increased body weight, fat mass, and dysregulated glucose metabolism; Il4-KO mice showed no beige adipogenesis defects, indicating IL-13-specific (not IL-4) signaling through IL-13Rα1. Preadipocyte-specific Il13ra1-KO and Il13-KO mouse models, cold exposure, β3-adrenergic agonist challenge, in vitro differentiation assays, STAT6/p38 MAPK pathway analysis The Journal of clinical investigation High 40198135
2025 IL-13 and IL-4 signal through IL-13Rα1 on enteric sensory neurons (PSNs) to amplify neuropeptide NMU and CGRPβ expression; PSN-specific Il13ra1 deletion abrogated cytokine-driven NMU/CGRPβ upregulation and impaired host defense to gastrointestinal helminth Heligmosomoides polygyrus, blunting muscularis immune responses. PSN-specific Il13ra1 deletion, in vitro neuron culture, in vivo helminth infection model, neuropeptide expression assays Science (New York, N.Y.) High 40403128
2025 A primate-specific IL-13Rα1 isoform (IL-13Rα1-LOR1a), generated by alternative splicing to a retrotransposable element-derived exon, lacks critical cytoplasmic tail domains and is partially signaling defective; when coexpressed with canonical IL-13Rα1, this isoform antagonizes receptor function and reduces cellular responsiveness to IL-4 and IL-13; IL13RA1 transcription is sexually dimorphic and regulated by estrogen. Alternative splicing characterization, isoform-specific overexpression, functional IL-4/IL-13 signaling assays, estrogen treatment experiments Science immunology High 40614216
2025 The RNA-binding protein IGF2BP3 directly binds IL4R and IL13RA1 mRNAs (which are also methylated), reducing their half-life; IGF2BP3 depletion increased IL4R and IL13RA1 mRNA stability, elevated IL-4Rα and IL-13Rα1 surface expression, and enhanced IL-13/IL-4-dependent STAT6 phosphorylation and downstream type 2 transcriptional responses in airway epithelial cells. IGF2BP3 RIP (RNA immunoprecipitation), mRNA half-life assays, siRNA knockdown, surface receptor expression (flow cytometry), STAT6 phosphorylation assay, genome-wide transcriptional readout bioRxivpreprint Medium bio_10.1101_2025.07.19.665669
2025 IL-13 receptor components IL4R and IL13RA1 are uniquely essential for Hodgkin lymphoma (HL) HRS cell survival; genome-wide CRISPR/Cas9 loss-of-function screens across >1000 cancer cell lines identified IL4R and IL13RA1 as selectively required in HL; recombinant IL-13 augmented HRS cell growth in vitro; blocking antibodies against IL4R or IL13R phenocopied genetic loss of function. Genome-wide CRISPR/Cas9 loss-of-function screen, in vitro proliferation assay with recombinant IL-13, antibody blockade experiments Nature communications High 41422061
2015 IL-13Rα1 regulates a lung epithelial cell-associated gene signature required for homeostasis; Il13ra1 deficiency results in exacerbated bleomycin-induced lung injury and fibrosis; the protective role was attributable to IL-13Rα1 expression in both structural and hematopoietic cells, and was independent of IL-17, IL-4, IL-13, IL-13Rα2, or type I IL-4R signaling. Il13ra1-/- mouse KO, bleomycin-induced pulmonary fibrosis model, transcriptional profiling, bone marrow chimera experiments Mucosal immunology Medium 26153764

Source papers

Stage 0 corpus · 86 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proceedings of the National Academy of Sciences of the United States of America 382 8552669
1997 Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrobial agents and chemotherapy 267 9371352
2019 IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nature immunology 186 30643264
2007 Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nature immunology 163 18066066
2010 Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. PloS one 119 20808962
2020 Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level. Cell reports 113 33296655
2012 Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells. Clinical cancer research : an official journal of the American Association for Cancer Research 106 22966020
2003 IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge. Journal of immunology (Baltimore, Md. : 1950) 74 12574374
2023 Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. Nature communications 70 36639371
2009 Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 70 19796199
2022 IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy 66 36445014
2007 IL-13 receptor isoforms: breaking through the complexity. Current allergy and asthma reports 62 17697639
2007 Enhanced growth and nodulation of pigeon pea by co-inoculation of Bacillus strains with Rhizobium spp. Bioresource technology 62 17826983
2020 A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Science immunology 57 32060143
2006 The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy. Neurosurgical focus 55 16709016
2012 Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide. Journal of immunology (Baltimore, Md. : 1950) 53 23169588
2015 A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal immunology 41 26153764
2022 RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect. Allergy 38 36153670
2015 IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology 38 26001777
2019 Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes. International journal of molecular sciences 34 31284553
2019 Signatures of selection for resistance to Haemonchus contortus in sheep and goats. BMC genomics 34 31615414
2017 New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure. Journal of the American Heart Association 34 28528324
2024 Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease. Nature communications 33 39009587
2022 Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. Allergy 31 36070083
2018 Bioactive effects of silica nanoparticles on bone cells are size, surface, and composition dependent. Acta biomaterialia 31 30326276
2003 Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. American journal of respiratory cell and molecular biology 31 12594065
2024 Zinc-Ion Anchor Induced Highly Reversible Zn Anodes for High Performance Zn-Ion Batteries. Angewandte Chemie (International ed. in English) 30 38579168
2017 Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress. Journal of neuroinflammation 29 28427412
2011 Genetic variations and interactions in anti-inflammatory cytokine pathway genes in the outcome of leprosy: a study conducted on a MassARRAY platform. The Journal of infectious diseases 29 21917900
2018 EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis. Biochemical pharmacology 27 30076848
2011 Denaturation of proteins by SDS and tetraalkylammonium dodecyl sulfates. Langmuir : the ACS journal of surfaces and colloids 27 21834533
2013 Recent progresses in identifying nuclear receptors and their families. Current topics in medicinal chemistry 26 23647541
1994 Suppression of albumin enhancer activity by H-ras and AP-1 in hepatocyte cell lines. Molecular and cellular biology 26 8114691
2010 Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 23 21071541
1994 Transforming growth factor beta 1 suppresses transformation in hepatocytes by regulating alpha 1 beta 1 integrin expression. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 21 8049157
2021 Identification of novel cell glycolysis related gene signature predicting survival in patients with breast cancer. Scientific reports 19 33597614
2015 Regulation signature of miR-143 and miR-26 in porcine Salmonella infection identified by binding site enrichment analysis. Molecular genetics and genomics : MGG 18 26589421
2024 Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy. The Journal of allergy and clinical immunology 17 39521279
2007 Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. The European respiratory journal 16 17392323
2023 Keratinocytes activated by IL-4/IL-13 express IL-2Rγ with consequences on epidermal barrier function. Experimental dermatology 15 36645024
2014 Genome-wide identification of nuclear receptor (NR) superfamily genes in the copepod Tigriopus japonicus. BMC genomics 15 25407996
2025 Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.) 13 40403128
2020 Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. Brain, behavior, and immunity 13 32276028
2021 Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology. Pharmacology research & perspectives 12 34676987
2019 Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor. Frontiers in genetics 12 31293618
2011 Modulation of transcriptional and inflammatory responses in murine macrophages by the Mycobacterium tuberculosis mammalian cell entry (Mce) 1 complex. PloS one 12 22039457
2023 Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer. Annals of medicine 11 37603701
2022 He's Yangchao Recipe Ameliorates Ovarian Oxidative Stress of Aging Mice under Consecutive Superovulation Involving JNK- And P53-Related Mechanism. Evidence-based complementary and alternative medicine : eCAM 11 35845588
2024 Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skin. Cell communication and signaling : CCS 10 39143467
2024 MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation. Cancer letters 9 38609001
2022 Allergic inflammation in lungs and nasal epithelium of rat model is regulated by tissue-specific miRNA expression. Molecular immunology 9 35537355
2022 Typical response of CD14++CD16- monocyte to knee synovial derived mediators as a key target to overcome the onset and progression of osteoarthritis. Frontiers in medicine 9 36106324
2000 Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics 9 11003391
2024 Interleukin Profiling in Atopic Dermatitis and Chronic Nodular Prurigo. International journal of molecular sciences 7 39126011
2022 Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival. Therapeutic advances in medical oncology 7 36579028
2021 Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: A mutational accumulation scoring approach. Biomarker research 7 34635181
2018 Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses. PloS one 7 30183726
1989 Effect of nitrate, ammonium, light and a plastidic factor on the appearance of multiple forms of nitrate reductase in mustard (Sinapis alba L.) cotyledons. Planta 7 24212274
2025 Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity. The Journal of clinical investigation 5 40198135
2023 Identification through machine learning of potential immune- related gene biomarkers associated with immune cell infiltration in myocardial infarction. BMC cardiovascular disorders 5 36978012
2022 Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis. Journal of inflammation research 5 35966004
2020 Application of Machine Learning Methods in Predicting Nuclear Receptors and their Families. Medicinal chemistry (Shariqah (United Arab Emirates)) 5 31584374
2022 Temporal Variability in Inflammatory Gene Methylation and Delirium in Critically Ill Patients. American journal of critical care : an official publication, American Association of Critical-Care Nurses 4 36045041
2025 SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps. Experimental & molecular medicine 3 40195539
2025 IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis. The Journal of clinical investigation 3 40454479
2004 Expression, purification, and initial structural characterization of rat orphan nuclear receptor NOR-1 LBD domain. Protein expression and purification 3 15358368
2025 Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses. Science immunology 2 40614216
2025 Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy. Allergy 2 40654284
2025 Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer's disease mouse model. Acta neuropathologica communications 2 40931359
2024 Ultrastructural study of neuronal cells and localization of ghrelin-like peptide and its receptor in the ganglia of the golden apple snail (Pomacea canaliculata). Tissue & cell 2 38493758
2023 [Interferon-related gene array in predicting the efficacy of interferon therapy in chronic hepatitis B]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 2 36854551
2023 Oncostatin M's Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation. Biomedicines 2 38137445
2013 Methylation status of immune response genes promoters in cell-free DNA differs in hemodialyzed patients with diabetic nephropathy according to the intensity of anemia therapy. Blood purification 2 24496200
2025 Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. bioRxiv : the preprint server for biology 1 39896575
2025 Synergistic Acid-Base Interfaces in Phosphoric Acid-Doped Polymer Electrolytes for Efficient H2/O2 Fuel Cells. ACS applied materials & interfaces 1 41083430
2025 Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. Nature communications 1 41422061
2024 Screening differentially expressed proteins to distinguish thymoma (B1 and B3) from thymic cysts based on tandem mass tag (TMT) technology. Journal of cardiothoracic surgery 1 39434140
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