Affinage

IL13RA1

Interleukin-13 receptor subunit alpha-1 · UniProt P78552

Length
427 aa
Mass
48.8 kDa
Annotated
2026-06-10
87 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL13RA1 encodes the low-affinity IL-13-binding chain of the IL-13 receptor, a hemopoietin-family receptor subunit that binds IL-13 but not IL-4 and, when stably expressed, reconstitutes high-affinity IL-13 receptors competent for proliferative signaling (PMID:8552669). IL-13Rα1 heterodimerizes with IL-4Rα to form the type II IL-4 receptor, the signaling-competent IL-13 receptor that transduces both IL-13 and IL-4 responses, in contrast to the decoy IL-13Rα2 (PMID:17697639). Downstream, IL-13Rα1 engagement drives STAT6 phosphorylation and, in adipocytes, p38 MAPK, coupling receptor occupancy to target-gene programs (PMID:25766112, PMID:40198135). Genetic loss-of-function studies establish that IL-13Rα1 is the essential mediator of IL-13-driven tissue pathology and homeostasis across diverse organs: it is required for alternative macrophage activation (PMID:25766112), allergen-induced airway resistance and mucus production (PMID:18480254, PMID:21957151), experimental atopic dermatitis and epidermal barrier dysfunction through downstream IL-2Rγ induction (PMID:32060143, PMID:36645024), and eosinophilic esophagitis driven specifically by receptor expression on epithelial cells (PMID:36070083), while conversely protecting against bleomycin lung injury and maintaining myocardial homeostasis (PMID:26153764, PMID:28528324). Beyond classical type 2 immunity, IL-13Rα1 functions in preadipocytes to drive beige adipogenesis via PPARγ (PMID:40198135), in enteric sensory neurons to amplify NMU and CGRPβ neuropeptide expression for anti-helminth defense (PMID:40403128), and as a synaptic protein that potentiates NMDAR/AMPAR phosphorylation and CREB-mediated transcription (PMID:36639371). Receptor abundance is tuned post-transcriptionally by miR-31/miR-155 targeting of the 3'UTR (PMID:29438285) and by IGF2BP3 binding that destabilizes the mRNA [PMID:bio_10.1101_2025.07.19.665669], and a primate-specific signaling-defective isoform (IL-13Rα1-LOR1a) generated by retrotransposon exonization antagonizes canonical receptor function (PMID:40614216). Dysregulated or overexpressed IL-13Rα1 constitutively activates JAK-STAT signaling and is selectively required for survival of Hodgkin Reed-Sternberg cells and oncogenic in primary mediastinal large B-cell lymphoma (PMID:41017961, PMID:41422061).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1996 High

    Established the molecular identity of the IL-13 receptor binding chain, answering whether a dedicated subunit confers IL-13 specificity distinct from IL-4.

    Evidence Transient and stable receptor reconstitution in COS-7 and CTLL-2 cells with binding and proliferation assays

    PMID:8552669

    Open questions at the time
    • Did not resolve the partner chain required for high-affinity signaling in physiological cells
    • No structural model of the ligand-binding interface
  2. 2000 Medium

    Defined the gene structure, cytokine-receptor-family signatures, alternative splicing, and tissue co-expression with Il4ra, situating IL-13Rα1 as the dominant receptor chain in lymphohematopoietic cells.

    Evidence Gene cloning, genomic Southern analysis, RT-PCR expression, and interspecific backcross mapping in mouse

    PMID:11003391

    Open questions at the time
    • Functional role of soluble splice isoforms not tested
    • Single study
  3. 2007 Medium

    Consolidated the receptor architecture, establishing that IL-13Rα1/IL-4Rα forms the signaling type II IL-4 receptor while IL-13Rα2 acts as a decoy.

    Evidence Review synthesizing prior receptor binding, signaling, and structural data

    PMID:17697639

    Open questions at the time
    • No new primary data
    • Stoichiometry and assembly kinetics not addressed
  4. 2008 High

    Genetically dissected which allergic lung phenotypes depend on IL-13Rα1, distinguishing type II IL-4R-driven effector responses from receptor-independent immune readouts.

    Evidence Il13ra1−/− mice with allergen/cytokine challenge, lung pathology, and global expression profiling

    PMID:18480254

    Open questions at the time
    • Cell types responsible not fully resolved in this study
    • Did not separate IL-13 from IL-4 signaling contributions mechanistically
  5. 2011 High

    Showed that IL-13Rα1 dependence of eosinophil recruitment is governed by the IL-4/IL-13 ratio and operates via chemokines rather than direct signaling in eosinophils.

    Evidence Il13ra1−/− mice across multiple aeroallergen models with eosinophil adoptive transfer

    PMID:21957151

    Open questions at the time
    • Molecular basis of differential cytokine-ratio sensing not defined
  6. 2015 High

    Delineated IL-13Rα1-dependent versus -independent signaling in macrophages, showing IL-13 absolutely requires the chain for STAT6 and alternative activation whereas IL-4 can bypass it.

    Evidence Reciprocal Il13ra1 and Il2rg knockout macrophages with STAT6 phosphorylation, gene expression, and fusion assays

    PMID:25766112

    Open questions at the time
    • Did not address non-macrophage cell types
    • Quantitative signaling thresholds not measured
  7. 2015 High

    Revealed a protective, homeostatic role for IL-13Rα1 in lung epithelium, contrasting with its pathogenic role in allergy.

    Evidence Il13ra1−/− mice in bleomycin injury with transcriptional profiling and bone marrow chimeras

    PMID:26153764

    Open questions at the time
    • Ligand driving the protective epithelial signature not identified
    • Direct downstream effectors of homeostatic program unresolved
  8. 2017 Medium

    Extended IL-13Rα1 function beyond immunity to cardiac homeostasis and to neuronal vulnerability, establishing context-dependent roles in non-immune tissues.

    Evidence Il13ra1−/− mice with echocardiography and pathway analysis (heart); Il13ra1 KO mice in chronic restraint stress with TH-neuron counting (brain)

    PMID:28427412 PMID:28528324

    Open questions at the time
    • Cardiac signaling effectors inferred bioinformatically, not validated
    • Neuronal loss delayed but not prevented, indicating partial pathway redundancy
  9. 2018 High

    Identified post-transcriptional repression of IL13RA1 by specific miRNAs as a brake on IL-13 signaling in inflamed gut epithelium.

    Evidence 3'UTR luciferase reporters, miRNA mimic transfection, STAT6/target-gene readouts, and ex vivo UC biopsy validation

    PMID:29438285

    Open questions at the time
    • In vivo physiological impact of miR-31/miR-155 regulation not tested
    • Other 3'UTR regulators not surveyed
  10. 2020 High

    Pinpointed IL-13Rα1 on nonhematopoietic cells as the driver of atopic dermatitis and identified a gain-of-function binding-domain variant heightening IL-13 neurotoxicity.

    Evidence Il13ra1−/− mice, bone marrow chimeras, cytokine neutralization across two AD models; patient SNP functional assays in SH-SY5Y neurons under oxidative stress

    PMID:32060143 PMID:32276028

    Open questions at the time
    • SNP effect tested in a single cell line with indirect inference on binding residue
    • Structural mechanism of the gain-of-function not resolved
  11. 2021 Medium

    Placed IL-13Rα1 within a regulatory circuit where PGD2-CRTH2 signaling downregulates epithelial receptor expression to restrain type 2 cytokine programs.

    Evidence CRTH2 KO mice, intestinal organoids, and helminth infection with Il13ra1 expression analysis

    PMID:34283207

    Open questions at the time
    • IL-13Rα1 downregulation is one node among several CRTH2 effects
    • Direct transcriptional mechanism not defined
  12. 2022 High

    Demonstrated that epithelial-cell IL-13Rα1 is the critical mediator of eosinophilic esophagitis, validated in human disease tissue.

    Evidence Global and epithelial-specific (Krt14Cre) Il13ra1 KO mice, IL-13 neutralization, and human EoE scRNA-seq

    PMID:36070083

    Open questions at the time
    • Downstream epithelial effectors of remodeling not fully enumerated
  13. 2023 High

    Established IL-13Rα1 as a synaptic receptor coupling IL-13 to glutamate-receptor phosphorylation, synaptic activity, and neuroprotection, and traced a mechanistic chain from receptor to IL-2Rγ-dependent epidermal barrier dysfunction.

    Evidence Co-IP, synaptic activity and NMDAR/AMPAR phosphorylation assays, TBI models and human tissue (brain); IL13RA1/IL2RG KO reconstructed human epidermis with JAK inhibitors (skin)

    PMID:36639371 PMID:36645024

    Open questions at the time
    • Synaptic signaling intermediates between receptor and NMDAR phosphorylation not defined
    • Spatial organization of receptor at the synapse unresolved
  14. 2025 High

    Expanded IL-13Rα1 mechanism into metabolism, enteric neuroimmunity, lymphoma oncogenesis, isoform-based and RNA-binding-protein regulation, and sexually dimorphic estrogen control, building a multi-tissue picture of receptor function and tuning.

    Evidence Preadipocyte-specific KO with STAT6/p38 dissection (beiging); PSN-specific KO with neuropeptide rescue (helminth defense); CRISPR screens and Ba/F3 transformation (Hodgkin/PMBCL); RIP and half-life assays for IGF2BP3 (preprint); RNA-seq isoform and estrogen-regulation assays for LOR1a

    PMID:40198135 PMID:40403128 PMID:40614216 PMID:41017961 PMID:41422061 PMID:41446728

    Open questions at the time
    • IGF2BP3 regulation rests on a single preprint lab
    • Oncogenic mechanism in PMBCL relies on Ba/F3 surrogate rather than primary lymphoma cells
    • Physiological role of LOR1a antagonism in human disease not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse, sometimes opposing tissue outcomes (pathogenic in allergy, protective in lung/heart, oncogenic in lymphoma) are encoded by a single receptor chain remains unresolved.
  • No structural model of the type II IL-4R signaling complex in the timeline
  • Determinants selecting STAT6 versus p38 versus glutamate-receptor outputs across cell types not defined
  • Mechanism converting receptor overexpression into ligand-independent constitutive JAK-STAT activation not fully resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0048018 receptor ligand activity 1 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4 R-HSA-1643685 Disease 2
Partners
IGF2BP3IL4R
Complex memberships
type II IL-4 receptor (IL-13Rα1/IL-4Rα)

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 IL13RA1 (NR4) encodes a low-affinity IL-13 binding subunit (IL-13 receptor alpha chain) of the hemopoietin receptor family. Transient expression in COS-7 cells showed NR4 binds IL-13 but not IL-4 or other interleukins. Stable expression in CTLL-2 cells generated high-affinity IL-13 receptors capable of transducing a proliferative signal and produced cross-competition with IL-4 binding, establishing IL-13Rα1 as the primary binding subunit of the IL-13 receptor and a component of IL-4 receptors. Transient expression in COS-7 cells, stable transfection in CTLL-2 cells, receptor binding assays, proliferation assays Proceedings of the National Academy of Sciences of the United States of America High 8552669
2007 IL-13Rα1 forms a heterodimer with IL-4Rα that constitutes the type II IL-4 receptor, a signaling IL-13 receptor. This heterodimeric complex mediates functional IL-13 signaling, in contrast to IL-13Rα2, which acts as a decoy receptor due to its short cytoplasmic tail. Review synthesizing receptor binding, signaling, and structural data from multiple prior studies Current allergy and asthma reports Medium 17697639
2008 IL-13Rα1 is essential for IL-13-induced and IL-4-induced (via type II IL-4R) allergic lung pathology including airway resistance, mucus, TGF-β, and eotaxin production. Il13ra1−/− mice showed that airway resistance, mucus, and eotaxin production are critically dependent on IL-13Rα1, whereas cellular infiltration and IgE responses to T cell-dependent antigens are IL-13Rα1-independent. Marker genes of alternatively activated macrophages are differentially regulated by type I versus type II IL-4R. Il13ra1−/− mouse model, allergen/IL-4/IL-13 challenge, lung pathology, global expression profiling Proceedings of the National Academy of Sciences of the United States of America High 18480254
2015 IL-13Rα1 chain is essential for IL-13-induced STAT6 activation and induction of the alternative macrophage activation (AMA) pathway (Arg1, Retnla, Ccl11 expression, membrane fusion, giant cell formation), but is not required for IL-4-induced responses in macrophages. IL-4 can still signal through type II IL-4 receptors via IL-13Rα1 when γc is absent, but IL-13 fails entirely to activate STAT6 or AMA genes in Il13ra1 KO macrophages. Il13ra1 and Il2rg knockout macrophages, STAT6 phosphorylation assays, gene expression, macrophage fusion assay Journal of innate immunity High 25766112
2000 The mouse Il13ra1 gene spans ~56 kb with 11 exons and shares genomic structure with class I cytokine receptor family genes, including conserved cysteines, WSxWS motif, and Box1. Alternative mRNA splicing generates soluble IL-13Rα1 isoforms. Il13ra1 maps to the proximal mouse X chromosome. Il13ra1 mRNA is co-expressed with Il4ra in myeloid and NK cells (where IL-13 acts), while Il13ra2 is absent from these cells, establishing IL-13Rα1 as the major receptor complex component in lymphohematopoietic cells. Gene cloning, genomic Southern analysis, RT-PCR expression analysis, interspecific backcross mapping Immunogenetics Medium 11003391
2011 IL-13Rα1 regulates aeroallergen-induced airway resistance and mucus production in a murine asthma model. Aspergillus-induced eosinophil recruitment and chemokine production are largely IL-13Rα1-dependent, whereas HDM-induced eosinophilia is IL-13Rα1-independent, correlating with a higher IL-4/IL-13 ratio after HDM challenge. Eosinophil adoptive transfer experiments showed near-ablation of lung eosinophilia in Il13ra1−/− mice after Aspergillus challenge, indicating chemokine-mediated recruitment rather than direct IL-13 signaling in eosinophils. Il13ra1−/− mice, multiple aeroallergen challenge models, eosinophil adoptive transfer, cytokine measurement Journal of immunology High 21957151
2015 IL-13Rα1 exerts a protective role in bleomycin-induced lung injury. Il13ra1-deficient mice showed exacerbated bleomycin-induced disease. Transcriptional profiling demonstrated an epithelial cell-associated gene signature homeostatically dependent on IL-13Rα1. Increased pathology was attributed to IL-13Rα1 expression in both structural and hematopoietic cells, and was not due to increased responsiveness to IL-17, IL-4, IL-13, or altered IL-13Rα2/type I IL-4R signaling. Il13ra1−/− mice, bleomycin lung injury model, transcriptional profiling, bone marrow chimera experiments Mucosal immunology High 26153764
2017 IL-13Rα1 is present in the myocardium and is required for myocardial homeostasis. Il13ra1-deficient mice develop severe myocardial dysfunction and dyssynchrony (reduced ejection fraction, increased end-diastolic diameter). Bioinformatic analysis indicates IL-13Rα1 regulates extracellular matrix and glucose metabolism pathways in the heart; its deficiency is associated with reduced collagen deposition under normal and pressure-overload conditions. Il13ra1−/− mice, echocardiography, bioinformatic pathway analysis of mouse hearts, collagen quantification, human heart sample analysis Journal of the American Heart Association Medium 28528324
2017 IL-13 signaling via IL-13Rα1 increases the vulnerability of dopaminergic neurons in the substantia nigra pars compacta (SNc) to oxidative stress. IL-13 is produced by microglial cells and a fraction of TH-positive neurons in the SNc. Lack of IL-13Rα1 (Il13ra1 Y/- mice) delayed but did not prevent loss of SNc dopaminergic neurons during chronic restraint stress. Il13ra1 KO mice, chronic restraint stress model, immunofluorescence, in situ hybridization, TH neuron counting, oxidative stress markers Journal of neuroinflammation Medium 28427412
2018 miR-31 and miR-155 directly target the 3' UTR of IL13RA1 mRNA, reducing IL-13Rα1 mRNA and protein expression. Transfection of miR-31 and miR-155 mimics blocked IL-13-dependent STAT6 phosphorylation and downstream target gene induction (SOCS1, CCL26/eotaxin-3) in HT-29 gut epithelial cells. These miRNAs are upregulated in inflamed UC mucosa and downregulate IL13RA1 in ex vivo UC biopsies, thereby limiting IL-13 signaling. 3'UTR luciferase reporter assay, miRNA mimic transfection, Western blot, STAT6 phosphorylation assay, qRT-PCR, ex vivo biopsy transfection Genes High 29438285
2020 IL-13Rα1 (as part of the type II IL-4R composed of IL-4Rα and IL-13Rα1) mediates experimental atopic dermatitis. Il13ra1−/− mice were protected from dermatitis (ear/epidermal thickening). TNF-α induction was dependent on the type II IL-4R, whereas IL-4, IgE, CCL24, and skin eosinophilia were dependent on the type I IL-4R. Bone marrow chimera experiments showed dermatitis and TNF-α/CXCL1/CCL11 expression were exclusively mediated by IL-13 signaling via type II IL-4R on nonhematopoietic cells. Il13ra1−/− mice, two AD models, IL-4/IL-13 neutralization, bone marrow chimeras, pharmacological IL-13Rα1 targeting Science immunology High 32060143
2021 PGD2 acting via its receptor CRTH2 downregulates intestinal epithelial Il13ra1 expression and reverses type 2 cytokine-mediated effects (suppression of epithelial cell proliferation, promotion of goblet cell accumulation). CRTH2-deficient small intestinal organoids showed enhanced budding and goblet cell differentiation. During helminth infection or in organoids, PGD2-CRTH2 negatively regulates the type 2 cytokine-driven epithelial program partly through modulation of IL-13Rα1 expression. CRTH2 KO mice, nonhematopoietic-specific CRTH2 KO, intestinal organoids, helminth infection model, Il13ra1 expression analysis The Journal of experimental medicine Medium 34283207
2022 IL-13Rα1 expressed on esophageal epithelial cells is the critical mediator of experimental eosinophilic esophagitis (EoE). Il13ra1−/− mice and Krt14Cre/Il13ra1fl/fl mice (epithelial-specific deletion) were protected from antigen-induced esophageal epithelial/lamina propria thickening, basal cell proliferation, eosinophilia, and tissue remodeling. In vivo IL-13 neutralization replicated protection, and human EoE scRNA-seq confirmed predominant IL-13Rα1 expression in epithelial cells. Il13ra1−/− mice, conditional epithelial KO (Krt14Cre/Il13ra1fl/fl), IL-13 antibody neutralization, scRNA-seq of human EoE biopsies Allergy High 36070083
2023 IL-13 and its receptor IL-13Rα1 are neuronal, synaptic proteins in mouse, rat, and human brains. Their engagement upregulates phosphorylation of NMDAR and AMPAR subunits, increases synaptic activity, and activates CREB-mediated transcription. IL-13 upregulation following traumatic brain injury protects neurons from excitotoxic death. Immunofluorescence, co-immunoprecipitation, synaptic activity assays, NMDAR/AMPAR phosphorylation assays, TBI mouse models, human CSF and brain sample analysis Nature communications High 36639371
2020 A missense SNP in IL13RA1 (rs145868092, leucine to phenylalanine substitution affecting a residue critical for IL-13 binding) confers a gain-of-function that increases the cytotoxic activity of IL-13 on human SH-SY5Y neurons exposed to sublethal oxidative stress, suggesting that IL-13Rα1 mediates IL-13-dependent neuronal vulnerability to oxidative damage. Patient SNP identification, neuronal cell viability assays with oxidative stress agents (H2O2, t-BHP, RSL3/ferroptosis inducer), mutant vs wild-type comparison Brain, behavior, and immunity Medium 32276028
2023 IL-2Rγ expression in keratinocytes is induced by IL-4/IL-13 acting through the type II IL-4Rα/IL-13Rα1 receptor; this induction is absent in IL13RA1 KO reconstructed human epidermis (RHE) and is blocked by JAK inhibitors. IL-2Rγ induction is functionally required for IL-4/IL-13-mediated epidermal barrier alteration, establishing that IL-13Rα1-dependent signaling drives downstream IL-2Rγ induction and barrier dysfunction. Reconstructed human epidermis (RHE), IL13RA1 KO RHE, IL2RG KO RHE, JAK inhibitor treatment, gene expression analysis Experimental dermatology High 36645024
2025 Sexually dimorphic IL13RA1 transcription is regulated by estrogen. A primate-specific IL-13Rα1 isoform (IL-13Rα1-LOR1a) is created by facultative splicing to an alternative terminal exon composed of retrotransposable elements (RTEs), which replaces 3'UTR sequences implicated in IL13RA1 mRNA stability and removes critical cytoplasmic tail domains, rendering this isoform partially signaling-defective. When co-expressed, IL-13Rα1-LOR1a antagonizes canonical receptor function, reducing cellular responsiveness to IL-4 and IL-13. RNA-seq isoform analysis, splice variant characterization, estrogen regulation assay, signaling assays (STAT6 phosphorylation), co-expression functional assays Science immunology High 40614216
2025 IL-13 signaling via IL-13Rα1 in preadipocytes drives beige adipogenesis by upregulating PPARγ expression and activity through downstream effectors STAT6 and p38 MAPK. Preadipocyte-specific Il13ra1 KO mice are refractory to cold- and β3-adrenergic agonist-induced beiging in inguinal white adipose tissue, and exhibit increased body weight, fat mass, and dysregulated glucose metabolism. Il4 KO mice show no defects, indicating this is IL-13-specific signaling. Preadipocyte Il13ra1-KO mice, Il13-KO mice, in vitro adipogenesis assays, STAT6/p38 MAPK inhibition, cold exposure, β3-agonist treatment, metabolic phenotyping The Journal of clinical investigation High 40198135
2025 IL-13 acting via IL-13Rα1 on enteric primary sensory neurons (PSNs) amplifies neuropeptide NMU and CGRPβ expression both in vitro and in vivo. PSN-specific Il13ra1 deletion impaired host defense to gastrointestinal helminth Heligmosomoides polygyrus and blunted muscularis immune responses; co-administration of NMU23 and CGRPβ rescued these deficits, establishing essential neuroimmune cross-talk downstream of IL-13Rα1. PSN-specific Il13ra1 conditional KO, helminth infection model, in vitro cytokine stimulation of neurons, neuropeptide co-administration rescue experiments Science High 40403128
2025 In primary mediastinal large B-cell lymphoma (PMBCL), overexpressed IL-13Rα1 (resulting from Xq24 copy number gains or epigenetic reactivation) constitutively activates the JAK-STAT signaling pathway and transforms murine pro-B cells (Ba/F3 cells) in vitro, identifying IL-13Rα1 as an oncogenic driver in PMBCL. Molecular cytogenetics, RNAseq, immunohistochemistry, Ba/F3 cell transformation assay, JAK-STAT signaling assay HemaSphere Medium 41017961
2025 IL4R and IL13RA1, as heterodimeric components of the IL-13 receptor, are uniquely essential for survival of Hodgkin Reed-Sternberg (HRS) cells. Genome-wide CRISPR/Cas9 loss-of-function screens across >1000 cancer cell lines identified these genes as selectively required in Hodgkin lymphoma. Recombinant IL-13 augments HRS cell proliferation in vitro, and blocking antibodies against IL4R or IL13Rα1 phenocopy genetic loss of function. Genome-wide CRISPR/Cas9 loss-of-function screen across >1000 cell lines, in vitro proliferation assay with recombinant IL-13, monoclonal antibody blocking Nature communications High 41422061
2025 The RNA-binding protein IGF2BP3 directly binds IL4R and IL13RA1 mRNAs (which are also methylated), reducing their stability. Depleting IGF2BP3 increased IL4R and IL13RA1 mRNA half-life, elevated IL-4Rα and IL-13Rα1 surface expression, and enhanced IL-13/IL-4-dependent STAT6 phosphorylation and downstream transcriptional responses, establishing IGF2BP3 as a post-transcriptional inhibitor of type II IL-4R complex expression. RNA immunoprecipitation, mRNA half-life assays, siRNA knockdown, surface receptor quantification by flow cytometry, STAT6 phosphorylation assays, genome-wide transcriptomics bioRxivpreprint Medium bio_10.1101_2025.07.19.665669
2025 Basophils recruited to the spleen following traumatic brain injury activate splenic B cells and dendritic cells via IL-13/IL-13Rα1 signaling, leading to IL-13Rα1 phosphorylation and upregulation of the long non-coding RNA NORAD in B cells and DCs. This early recruitment is inhibited by ethanol intoxication in TBI, which prevents IL-13Rα phosphorylation. Phospho-proteomics, immunofluorescence, ELISA, super-resolution microscopy, single mRNA in situ hybridization, closed head injury mouse model Journal of neuroinflammation Medium 41408561
2025 IL-13 signaling via IL-13Rα1/IL-4R promotes keratinocyte proliferation and migration in cutaneous squamous cell carcinoma. Functional assays using IL13RA1 and IL4R knockdown confirmed that the IL-13/IL-13Rα1/IL-4R signaling axis drives keratinocyte proliferative and migratory responses. scRNA-seq ligand-receptor analysis, IL13RA1 and IL4R siRNA knockdown, keratinocyte proliferation and migration assays iScience Medium 41446728

Source papers

Stage 0 corpus · 87 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proceedings of the National Academy of Sciences of the United States of America 383 8552669
1997 Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrobial agents and chemotherapy 268 9371352
2008 Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 222 18480254
2019 IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nature immunology 189 30643264
2020 Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level. Cell reports 119 33296655
2011 Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis and rheumatism 116 21425123
2011 Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival. BMC medical genomics 75 21649900
2003 IL-13 is sufficient for respiratory syncytial virus G glycoprotein-induced eosinophilia after respiratory syncytial virus challenge. Journal of immunology (Baltimore, Md. : 1950) 74 12574374
2023 Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. Nature communications 71 36639371
2009 Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 70 19796199
2010 Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Gut 69 20732914
2022 IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy 66 36445014
2007 IL-13 receptor isoforms: breaking through the complexity. Current allergy and asthma reports 62 17697639
2020 A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis. Science immunology 57 32060143
2006 The IL-4 and IL-13 pseudomonas exotoxins: new hope for brain tumor therapy. Neurosurgical focus 55 16709016
2021 PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. The Journal of experimental medicine 48 34283207
2018 MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1. Genes 48 29438285
2015 A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair. Mucosal immunology 41 26153764
2006 IL13RA2 gene polymorphisms are associated with systemic sclerosis. The Journal of rheumatology 41 16981293
2024 Single-cell transcriptomics analysis of bullous pemphigoid unveils immune-stromal crosstalk in type 2 inflammatory disease. Nature communications 39 39009587
2022 RNA sequencing of single allergen-specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect. Allergy 38 36153670
2015 IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. American journal of physiology. Lung cellular and molecular physiology 38 26001777
2017 New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure. Journal of the American Heart Association 35 28528324
2019 Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in Keratinocytes. International journal of molecular sciences 34 31284553
2022 Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis. Allergy 33 36070083
2011 IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses. Journal of immunology (Baltimore, Md. : 1950) 33 21957151
2015 The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4. Journal of innate immunity 31 25766112
2003 Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. American journal of respiratory cell and molecular biology 31 12594065
2017 Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress. Journal of neuroinflammation 30 28427412
2013 Recent progresses in identifying nuclear receptors and their families. Current topics in medicinal chemistry 26 23647541
2003 Identification and characterization of interleukin-13 receptor in human medulloblastoma and targeting these receptors with interleukin-13-pseudomonas exotoxin fusion protein. Croatian medical journal 24 12950150
2022 Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis. Scientific reports 23 35194091
1994 Transforming growth factor beta 1 suppresses transformation in hepatocytes by regulating alpha 1 beta 1 integrin expression. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 21 8049157
2024 Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy. The Journal of allergy and clinical immunology 19 39521279
2021 Identification of novel cell glycolysis related gene signature predicting survival in patients with breast cancer. Scientific reports 19 33597614
2025 Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science (New York, N.Y.) 18 40403128
2017 Nonomuraea rhodomycinica sp. nov., isolated from peat swamp forest soil. International journal of systematic and evolutionary microbiology 18 28155814
1992 Transforming growth factor beta 1 partially suppresses the transformed phenotype of ras-transformed hepatocytes. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 17 1332741
2016 A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients. Mediators of inflammation 16 26977119
2014 Genome-wide identification of nuclear receptor (NR) superfamily genes in the copepod Tigriopus japonicus. BMC genomics 16 25407996
2007 Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. The European respiratory journal 16 17392323
2023 Keratinocytes activated by IL-4/IL-13 express IL-2Rγ with consequences on epidermal barrier function. Experimental dermatology 15 36645024
2022 IL-4/IL-13 Axis in Allergic Rhinitis: Elevated Serum Cytokines Levels and Inverse Association With Tight Junction Molecules Expression. Frontiers in molecular biosciences 15 35372516
2020 Interleukins 4 and 13 and Their Receptors Are Differently Expressed in Gastrointestinal Tract Cancers, Depending on the Anatomical Site and Disease Advancement, and Improve Colon Cancer Cell Viability and Motility. Cancers 15 32512917
2023 Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer. Annals of medicine 13 37603701
2021 Meningioma genomics: a therapeutic challenge for clinicians. Journal of integrative neuroscience 13 34258948
2020 Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress. Brain, behavior, and immunity 13 32276028
2024 Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skin. Cell communication and signaling : CCS 12 39143467
2021 Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology. Pharmacology research & perspectives 12 34676987
2022 Allergic inflammation in lungs and nasal epithelium of rat model is regulated by tissue-specific miRNA expression. Molecular immunology 11 35537355
2018 Simultaneously Antimicrobial, Protein-repellent and Cell-compatible Polyzwitterion Networks: More Insight on Bioactivity and Physical Properties. ACS applied bio materials 11 34405136
2024 MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation. Cancer letters 9 38609001
2000 Characterization of the mouse interleukin-13 receptor alpha1 gene. Immunogenetics 9 11003391
2023 Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy. Journal of neuroinflammation 8 37533036
2024 Interleukin Profiling in Atopic Dermatitis and Chronic Nodular Prurigo. International journal of molecular sciences 7 39126011
2022 Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients' survival. Therapeutic advances in medical oncology 7 36579028
2021 Transcriptomes in peripheral blood of young females with temporomandibular joint osteoarthritis. Scientific reports 6 33893371
2025 SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps. Experimental & molecular medicine 5 40195539
2025 Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity. The Journal of clinical investigation 5 40198135
2023 Identification through machine learning of potential immune- related gene biomarkers associated with immune cell infiltration in myocardial infarction. BMC cardiovascular disorders 5 36978012
2022 Investigation on Probable Association Between IL-13, IL-13RA1, and IL-13RA2 Genes Polymorphism and Pulmonary Tuberculosis. Journal of inflammation research 5 35966004
2022 Temporal Variability in Inflammatory Gene Methylation and Delirium in Critically Ill Patients. American journal of critical care : an official publication, American Association of Critical-Care Nurses 5 36045041
2020 Application of Machine Learning Methods in Predicting Nuclear Receptors and their Families. Medicinal chemistry (Shariqah (United Arab Emirates)) 5 31584374
2025 Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy. Allergy 4 40654284
2025 Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer's disease mouse model. Acta neuropathologica communications 4 40931359
2016 Engineering Factor Xa Inhibitor with Multiple Platelet-Binding Sites Facilitates its Platelet Targeting. Scientific reports 4 27432161
2025 IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis. The Journal of clinical investigation 3 40454479
2025 Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. Nature communications 3 41422061
2024 The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop. Frontiers in toxicology 3 38694815
2004 Expression, purification, and initial structural characterization of rat orphan nuclear receptor NOR-1 LBD domain. Protein expression and purification 3 15358368
1999 The effect of high molecular weight kininogen on neutrophil adhesion to polymer surfaces. Immunopharmacology 3 10596864
2025 Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses. Science immunology 2 40614216
2024 Ultrastructural study of neuronal cells and localization of ghrelin-like peptide and its receptor in the ganglia of the golden apple snail (Pomacea canaliculata). Tissue & cell 2 38493758
2023 [Interferon-related gene array in predicting the efficacy of interferon therapy in chronic hepatitis B]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 2 36854551
2023 Oncostatin M's Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation. Biomedicines 2 38137445
2026 Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata. The Journal of allergy and clinical immunology 1 41740930
2025 Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. bioRxiv : the preprint server for biology 1 39896575
2025 Ruxolitinib Alleviates Inflammation and Fortifies Skin Barrier Function Through Dampening IL-13. Experimental dermatology 1 40678986
2007 Rat gene mapping in the post-genome sequencing era: the continued utility of cell hybrids to localize rat genes (Cks2, Ephb4, Fabp5, Il13ra1, Rpl10, Ssr4). Cytogenetic and genome research 1 17268179
2026 A Network Biology Framework for Exploring Molecular Mechanisms in Cystoid Macular Edema. Romanian journal of ophthalmology 0 42146949
2025 Circ-ATF7IP promotes IL13RA1 dependent M2 polarization of macrophage via sponging MiR-488-3p in papillary thyroid carcinoma. Biochimica et biophysica acta. General subjects 0 40945694
2025 Xq24/IL13RA1 aberrations as key drivers of female bias in primary mediastinal large B-cell lymphoma. HemaSphere 0 41017961
2025 Genetic and serum biomarkers of NSAID hypersensitivity reactions. Frontiers in pharmacology 0 41111521
2025 Basophils activate splenic B cells and dendritic cells via IL-13 signaling in acute traumatic brain injury. Journal of neuroinflammation 0 41408561
2025 Single-cell transcriptomic landscape of keratinocyte transformation from actinic keratosis to skin carcinoma. iScience 0 41446728
2024 Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin. Research square 0 38854033
2024 Screening and regulatory mechanism exploration of M1 macrophage polarization and efferocytosis-related biomarkers in coronary heart disease. Frontiers in cardiovascular medicine 0 39723414

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