Affinage

IL10RB

Interleukin-10 receptor subunit beta · UniProt Q08334

Length
325 aa
Mass
37.0 kDa
Annotated
2026-06-10
42 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL10RB (CRF2-4/IL-10R2) is an obligate, broadly shared signaling subunit of multiple class II cytokine receptor complexes, required to transduce the anti-inflammatory and antiviral programs of its cytokine partners (PMID:9463407, PMID:15123776). Genetic disruption abolishes IL-10 responsiveness while sparing type I and type II interferon signaling, and produces chronic colitis recapitulating IL-10 deficiency, establishing IL10RB as non-redundant in the IL-10 axis (PMID:9463407). Beyond IL-10 it serves as the common second chain partnering distinct primary R1 receptors for IL-22, IL-26, IFN-λ, and the IFN-υ/type IV IFN system, and neutralizing the IL-10R2 chain blocks signaling by all of these cytokines (PMID:10875937, PMID:11035029, PMID:15123776, PMID:30247785, PMID:35194032). Receptor assembly is sequential and conformation-dependent: IL10RB has negligible affinity for free cytokine and instead docks onto a composite surface formed only after the ligand engages its R1 chain, which remodels the cytokine (notably helix A of IL-10 and IL-22) to create the IL-10R2 epitope (PMID:15120653, PMID:16982608). Its crystal structure reveals a conserved binding epitope flanked by two clefts that accommodate the chemical and structural diversity of its many cytokine partners (PMID:20462497). Both the extracellular and intracellular domains of IL-10R2 are required for signal transduction; the intracellular domain shapes IL-10R1 conformation and the IL-10R2-associated kinase Tyk2 controls the amplitude of STAT3 phosphorylation and SOCS3 upregulation, the core node of IL-10's anti-inflammatory output (PMID:29016674). Loss-of-function mutation in IL10RB abolishes IL-10-induced STAT3 phosphorylation and SOCS3 expression in human macrophages, and gene correction restores anti-inflammatory regulation, demonstrating a causal requirement for IL10RB in this axis (PMID:33804706). Surface availability of IL-10R2 is post-translationally regulated: the protease KLK2 cleaves the IL-10R2 ectodomain (SYRIF, residues 58–63), reducing surface receptor and dampening IL-10 signaling (PMID:39106042).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1998 High

    Established that IL10RB is a non-redundant subunit of the IL-10 receptor, answering whether this orphan class II chain has a defined ligand system and physiological role.

    Evidence Homozygous CRFB4 gene knockout in mice with cytokine responsiveness and histopathology

    PMID:9463407

    Open questions at the time
    • Did not define the molecular partner chain (IL-10R1) interaction mechanism
    • Did not address whether the chain is shared by other cytokines
  2. 2000 High

    Showed that IL10RB is a shared chain serving IL-22 in addition to IL-10, reframing it as a common signaling subunit rather than an IL-10-specific receptor.

    Evidence Receptor reconstitution in COS/hamster cells, radiolabeled cytokine cross-linking, STAT activation and intracellular-domain swap assays

    PMID:10875937 PMID:11035029

    Open questions at the time
    • Did not establish the order of chain assembly
    • Did not resolve which residues mediate IL10RB binding
  3. 2004 Medium

    Extended the shared-chain model to four cytokine systems and introduced the sequential, conformation-triggered assembly mechanism, answering how one chain can serve diverse ligands.

    Evidence Neutralizing antibody blockade across IL-10, IL-22, IL-26 and IFN-λ signaling; ELISA and SPR binding with mutagenesis on IL-22

    PMID:15120653 PMID:15123776 PMID:15327950

    Open questions at the time
    • Assembly mechanism inferred from binding kinetics rather than direct structure
    • Glycan requirement defined for IL-22 only
  4. 2006 High

    Defined the conformational basis of ternary complex assembly for IL-10, showing IL10RB docks only after IL-10R1 binding remodels helix A of the cytokine.

    Evidence SPR binding measurements with cell-based signaling, interpreted against IL-10/IL-10R1 crystal structures

    PMID:16982608

    Open questions at the time
    • No direct structure of the IL10RB-bound ternary complex
    • Did not address whether the same conformational logic governs IFN-λ/IFN-υ complexes
  5. 2010 High

    Provided the structural explanation for IL10RB promiscuity by solving its ectodomain and identifying a conserved epitope flanked by two adaptable clefts.

    Evidence X-ray crystallography at 2.14 Å with alanine-scanning mutagenesis and computational docking of ternary complexes

    PMID:20462497

    Open questions at the time
    • Ternary complexes were modeled computationally, not crystallized
    • Intracellular signaling consequences not addressed structurally
  6. 2017 High

    Dissected functional contributions of the IL10RB extracellular versus intracellular domains and linked the chain to Tyk2-controlled STAT3 amplitude.

    Evidence Bone marrow-derived cells from IL-10R-/- and Tyk2-/- mice with STAT3 phosphorylation, SOCS3 and LPS-induced TNF-α readouts

    PMID:29016674

    Open questions at the time
    • Quantitative kinase-substrate relationship of Tyk2 to STAT3 not resolved
    • Mechanism by which intracellular domain alters IL-10R1 conformation unknown
  7. 2018 Medium

    Extended IL10RB function to antiviral IFN-λ4 signaling, showing the chain is required for type III interferon-mediated HIV restriction in macrophages.

    Evidence Antibody blockade of the IFN-λR1/IL-10R2 complex with STAT1 phosphorylation and ISG assays in HIV-infected macrophages

    PMID:30247785

    Open questions at the time
    • Single lab, single method (antibody blockade)
    • Direct binding of IFN-λ4 to IL10RB not measured
  8. 2021 High

    Demonstrated causality and reversibility of IL10RB function in a human system by showing loss-of-function abolishes and gene correction restores the IL-10/STAT3/SOCS3 axis.

    Evidence Patient iPSC-derived macrophages with lentiviral gene therapy and AAVS1 genome editing; STAT3, SOCS3 and cytokine secretion readouts

    PMID:33804706

    Open questions at the time
    • Did not test correction of other IL10RB-dependent cytokine systems
    • In vivo therapeutic durability not addressed
  9. 2022 High

    Identified IL10RB as the second chain for IFN-υ/type IV interferon, broadening its cytokine repertoire to a fifth receptor system.

    Evidence Chimeric receptor reconstitution in HEK293 cells with ISG and antiviral assays in zebrafish and Xenopus

    PMID:35194032

    Open questions at the time
    • Human IFN-υ system not characterized
    • Structural basis of IFN-υR1/IL10RB complex unresolved
  10. 2024 Medium

    Revealed post-translational control of IL10RB surface availability through proteolytic cleavage by KLK2, defining a mechanism for dampening IL-10 signaling.

    Evidence FRET peptide library cleavage mapping (SYRIF 58-63), FACS of surface IL-10R2, and macrophage IL-10 functional assays with KLK3 negative control

    PMID:39106042

    Open questions at the time
    • Physiological context of KLK2-mediated cleavage in vivo not established
    • Single lab
  11. 2024 Medium

    Implicated IL10RB in EMT-driven cancer cell properties and as a therapeutic antibody target, extending its role beyond canonical cytokine immunoregulation.

    Evidence Microarray, in vitro adhesion/invasion/chemoresistance assays, and mouse tumor models with anti-IL10RB blocking mAb and anti-PD1 combination

    PMID:41826681

    Open questions at the time
    • Ligand/signaling pathway driving the cancer phenotype not defined
    • Single lab, mechanism downstream of IL10RB unclear
  12. 2025 Medium

    Placed IL10RB in a microglial-lifespan signaling axis acting through JAK/STAT and lysosomal pH regulation, a non-classical role in CNS cell death.

    Evidence CRISPR screen in zebrafish with confocal imaging, LysoTracker, JAK/STAT epistasis and v-ATPase inhibition (preprint)

    PMID:bio_10.1101_2025.11.21.689277

    Open questions at the time
    • Preprint, single lab
    • Mechanistic link between IL10RB signaling and lysosomal acidification not resolved
    • Mammalian relevance untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How IL10RB selects among its many cytokine partners in vivo, and what governs the structure of the assembled, signaling-competent ternary complexes, remains unresolved.
  • No experimental crystal/cryo-EM structure of any full ternary complex
  • Determinants of partner selectivity in cells expressing multiple R1 chains unknown
  • Human IFN-υ and CNS roles not validated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-168256 Immune System 3 R-HSA-162582 Signal Transduction 2
Partners
IFNLR1IL10RAIL22RA1KLK2TYK2
Complex memberships
IFN-lambda receptor (IFN-lambdaR1/IL-10R2)IFN-upsilon receptor (IFN-upsilonR1/IL-10R2)IL-10 receptor (IL-10R1/IL-10R2)IL-22 receptor (IL-22R1/IL-10R2)

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 CRF2-4 (IL10RB) is an essential subunit of the IL-10 receptor complex: mice with homozygous disruption of the CRFB4 gene lose responsiveness to IL-10 but retain normal responsiveness to type I and type II interferons, and develop chronic colitis recapitulating the IL-10-deficient phenotype. Homologous recombination gene knockout in mice; cytokine responsiveness assays; histopathological analysis The Journal of experimental medicine High 9463407
2000 IL-22 signals through a receptor complex consisting of CRF2-4 (IL10RB) and a novel receptor chain (IL-22R/CRF2-9); CRF2-4 alone can bind IL-22 but both chains are required for functional signaling; IL-22 activates STATs 1, 3, and 5. Receptor expression in COS and hamster cells; STAT activation assays; radiolabeled cytokine cross-linking/binding assays The Journal of biological chemistry High 10875937 11035029
2000 IL10RB (IL-10R2) is a shared common chain of both the IL-10 and IL-22 (IL-TIF) receptor complexes; each chain (CRF2-9 and IL-10R2) can independently bind IL-TIF, but binding affinity is greater when both chains form the complete receptor complex; the CRF2-9 chain is responsible for STAT recruitment. Receptor reconstitution in hamster and COS cells; radiolabeled cytokine cross-linking; STAT activation assays; intracellular domain substitution experiments The Journal of biological chemistry High 11035029
2004 IL-10R2 (IL10RB) is a shared component of at least four distinct class II cytokine receptor complexes (IL-10, IL-22, IL-26, and IFN-lambda); neutralizing antibodies to the IL-10R2 chain block signaling by all four cytokines; IL-10R2 engagement occurs after the ligand binds its R1 chain, triggered by a conformational change. Neutralizing antibody blockade of cytokine signaling; receptor complex characterization; cell-based signaling assays Journal of leukocyte biology Medium 15123776
2004 The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix (helix A) and requires N-linked glycosylation at asparagine 54; a single fucosylated N-acetyl glucosamine at N54 is required for maximal IL-10R2 binding, and IL-22 mutants with reduced IL-10R2 binding show correspondingly reduced biological activity. Surface plasmon resonance (SPR); site-directed mutagenesis; glycosylation characterization; cell-based luciferase reporter assays Journal of molecular biology High 15327950
2004 IL-10R2 (IL10RB) binds to a surface created by the interaction between IL-22 and IL-22R, thereby further stabilizing the cytokine-receptor complex; IL-10R2 has undetectable affinity for IL-22 alone but substantially greater affinity for IL-22/IL-22R complexes. ELISA-based binding assays with biotinylated IL-22 and receptor-Fc fusion proteins; sequential addition experiments with receptor homodimers International immunopharmacology Medium 15120653
2006 Assembly of the IL-10 ternary signaling complex (IL-10/IL-10R1/IL-10R2) is sequential: IL-10 first binds IL-10R1, which induces conformational changes in helix A of IL-10 that create the IL-10R2 binding site; critical IL-10R2 binding residues are located in helix A adjacent to the IL-10R1 recognition surface. Surface plasmon resonance (SPR); cell-based signaling assays; comparison with IL-10/IL-10R1 crystal structures The Journal of biological chemistry High 16982608
2008 The IL-10R2 and IL-22R binding sites on IL-22 are topologically juxtaposed on adjacent and overlapping surfaces (helices A, D, F and loop AB); comprehensive mutagenesis identified amino acid residues individually important for IL-10R2 binding, considerably expanding the defined IL-10R2 binding surface on IL-22. Comprehensive site-directed mutagenesis; ELISA cell-based assays; structural modeling Journal of molecular biology Medium 18675824
2010 The crystal structure of the IL-10R2 ectodomain at 2.14 Å resolution reveals a conserved binding epitope surrounded by two clefts that accommodate the structural and chemical diversity of different cytokine partners; alanine scanning identified IL-10R2 residues required for cytokine binding, and computational models of IL-10/IL-10R1/IL-10R2 and IL-22/IL-22R1/IL-10R2 ternary complexes were derived. X-ray crystallography at 2.14 Å; alanine scanning mutagenesis; computational docking/modeling Structure (London, England : 1993) High 20462497
2017 Both the extracellular and intracellular domains of IL-10R2 (IL10RB) are required for transducing IL-10 signals; the intracellular domain of IL-10R2 influences the conformation of IL-10R1; IL-10-mediated responses depend on both IL-10R1 and IL-10R2 in dendritic cells, macrophages, and mast cells; IL-10R2-associated kinase Tyk2 controls the amplitude of STAT3 activation and SOCS3 upregulation but plays only a limited role in overall IL-10 responses. Bone marrow-derived cells from IL-10R-/- and Tyk2-/- mice; STAT3 phosphorylation assays; SOCS3 expression; LPS-induced TNF-α cytokine assays PloS one High 29016674
2012 Probiotic LGG upregulates IL-10R2 (IL10RB) subunit expression in developing murine colon, leading to enhanced IL-10 receptor-mediated signaling including increased STAT3 phosphorylation and SOCS3 expression; antibody-mediated blockade of the IL-10 receptor abrogated LGG-dependent reductions in TNF-α and MIP-2. Real-time PCR; STAT3 phosphorylation assays; antibody blockade of IL-10 receptor; murine model of intestinal injury PloS one Medium 23272193
2021 Loss-of-function mutation in IL10RB abolishes IL-10-induced STAT3 phosphorylation and SOCS3 expression in iPSC-derived macrophages, preventing IL-10-mediated suppression of LPS-induced cytokine secretion (IL-6, TNF-α); lentiviral gene correction or genome editing of IL10RB reconstitutes IL-10-inducible STAT3 phosphorylation, SOCS3 expression, and anti-inflammatory regulation. iPSC differentiation into macrophages; STAT3 phosphorylation assays; SOCS3 expression; cytokine secretion assays; lentiviral gene therapy and AAVS1 safe harbor genome editing Journal of personalized medicine High 33804706
2018 IFN-λ4 inhibits HIV infection of macrophages through signaling of the IFN-λR1/IL-10R2 receptor complex; antibodies against IFN-λR1/IL-10R2 compromise IFN-λ4-mediated HIV inhibition; IFN-λ4 enhances STAT1 phosphorylation and induces antiviral interferon-stimulated genes through this receptor complex. Antibody blockade of receptor complex; STAT1 phosphorylation assays; antiviral gene expression assays; HIV infection of macrophages Scandinavian journal of immunology Medium 30247785
2022 IL10RB is identified as a receptor subunit for IFN-υ (type IV interferon) together with IFN-υR1; IFN-υR1/IL-10R2 receptor complex mediates IFN-υ-stimulated gene expression and antiviral activity in zebrafish and Xenopus; the receptor of IFN-υ was verified as IFN-υR1 and IL-10R2 using a chimeric receptor approach. Chimeric receptor approach in HEK293 cells; ISG expression assays; antiviral activity assays in zebrafish and Xenopus laevis Nature communications High 35194032
2024 The extracellular domain of IL-10R2 (IL10RB) is a substrate for KLK2 (prostate kallikrein-2), which cleaves the sequence SYRIF at positions 58-63 of IL-10R2; KLK2 treatment reduces surface IL-10R2 expression on bone marrow-derived macrophages and significantly reduces IL-10-mediated inhibition of inflammatory responses (nitric oxide, TNF-α, IL-12 p40) to LPS/IFN-γ. Fluorescence resonance energy transfer peptide library assays; flow cytometry (FACS) of cell surface IL-10R2; in vitro macrophage stimulation with LPS/IFN-γ and IL-10; comparison with KLK3 (negative control) Biochemistry Medium 39106042
2025 il10rb perturbation in zebrafish reduces microglial death and decreases lysosomal acidification (reduced LysoTracker-positive lysosomes) without altering lysosome number or size, placing IL10RB in a signaling axis that controls microglial lifespan through lysosomal pH regulation; perturbation of il10, il10rb, and downstream JAK/STAT molecules all reduced microglial death. CRISPR screen in zebrafish using robotic confocal microscope; LysoTracker live imaging; genetic epistasis with JAK/STAT pathway genes; v-ATPase inhibition experiments bioRxivpreprint Medium bio_10.1101_2025.11.21.689277
2024 IL10RB overexpression in cancer cells undergoing EMT (driven by snail) enhances cellular adhesion, invasiveness, and chemoresistance; anti-IL10RB blocking monoclonal antibody attenuates these refractory properties and induces anti-tumor immunity in mouse tumor models; combining anti-IL10RB and anti-PD1 therapy has synergistic effects on tumor disappearance. GeneChip microarray; in vitro adhesion, invasion, and chemoresistance assays in cancer cells; mouse orthotopic tumor models; anti-IL10RB blocking mAb treatment BJC reports Medium 41826681

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. The Journal of biological chemistry 441 10875937
2000 Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. The Journal of biological chemistry 331 11035029
1998 The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. The Journal of experimental medicine 296 9463407
2004 The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. Journal of leukocyte biology 234 15123776
2006 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. The Journal of biological chemistry 115 16982608
2010 Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure (London, England : 1993) 74 20462497
2022 Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications 72 35194032
2004 The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation. Journal of molecular biology 62 15327950
2004 Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2. International immunopharmacology 57 15120653
2012 Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. PloS one 54 23272193
2008 IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. Journal of molecular biology 51 18675824
2008 Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. Biochemical and biophysical research communications 34 18588853
2009 Association study of IFNAR2 and IL10RB genes with the susceptibility and interferon response in HBV infection. Journal of viral hepatitis 33 19714778
2020 Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier. Frontiers in cellular and infection microbiology 27 32637365
1997 CRF2-4: isolation of cDNA clones encoding the human and mouse proteins. Gene 24 9047351
2017 Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain. PloS one 19 29016674
2022 A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. NPJ genomic medicine 15 36064543
1995 Structure of the human CRFB4 gene: comparison with its IFNAR neighbor. Journal of molecular evolution 13 7563119
2019 Candidiasis associated with very early onset inflammatory bowel disease: First IL10RB deficient case from the National Iranian Registry and review of the literature. Clinical immunology (Orlando, Fla.) 12 31096038
2018 IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex. Scandinavian journal of immunology 12 30247785
2021 Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages. Journal of personalized medicine 11 33804706
2021 IL10RB as a key regulator of COVID-19 host susceptibility and severity. medRxiv : the preprint server for health sciences 10 34100031
2013 IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population. Inflammation 10 23749100
2024 Fish IL-26 collaborates with IL-10R2 and IL-20R1 to enhance gut mucosal barrier during the antibacterial innate immunity. Developmental and comparative immunology 9 39154973
2013 Association of IFNAR2 and IL10RB genes in chronic hepatitis B virus infection. Tissue antigens 9 23745570
2023 Evolutionarily conserved IL-22 participates in gut mucosal barrier through its receptors IL-22BP, IL-10R2 and IL-22RA1 during bacterial infection in teleost. Developmental and comparative immunology 8 38081403
2024 Tumour-associated myeloid cells expressing IL-10R2/IL-22R1 as a potential biomarker for diagnosis and recurrence of pancreatic ductal adenocarcinoma. British journal of cancer 5 38643339
2023 Molecular characterization of nineteen cytokine receptor family B (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama amblycephala. Developmental and comparative immunology 5 37146740
2023 Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. International journal of molecular sciences 5 37511050
2013 The Pekin duck IL-10R2 common chain: cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis. International journal of immunogenetics 5 23331509
2020 The expression of β-Defensin-2, IL-22, IL-22R1 and IL-10R2 in rat model of Klebsiella pneumonia and their correlation with histological grades. Experimental lung research 4 32169023
2024 IFN-υ and its receptor subunits, IFN-υR1 and IL10RB in mallard Anas platyrhynchos. Poultry science 3 38564837
2024 Matched Unrelated Donor Hematopoietic Stem Cell Transplant as Successful Curative Therapy for IL10RB Mutation-Associated Very Early Onset IBD. Pediatric transplantation 3 39539152
2022 Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students. Genes 3 35205336
2025 Case Report: Novel IL10RB variant causing very early onset-inflammatory bowel disease. Frontiers in immunology 2 41122180
2023 Altered Expression of the HLA-G and IL10RB Genes in Placental Tissue of Women with Recurrent Pregnancy Loss. Clinical laboratory 2 37145066
2024 Clinical and cellular phenotypes resulting from a founder mutation in IL10RB. Clinical and experimental immunology 1 37503744
2024 A novel biallelic 19-bp deletion in the IL10RB gene caused infant-onset inflammatory bowel disease in a consanguineous family: a molecular docking simulation study and literature review. Molecular biology reports 1 38281300
2024 Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2). Biochemistry 1 39106042
2026 IL10RB expression in cancer cells is associated with evolutionary changes to solidify treatment resistance. BJC reports 0 41826681
2025 From chronic gastritis to gastric cancer: Mendelian randomisation and multi-omics interrogation of leukaemia inhibitory factor receptor (LIFR), hepatocyte growth factor (HGF), serine protease inhibitor E1 (SERPINE1) and interleukin-10 receptor subunit beta (IL10RB). International journal of biological macromolecules 0 41380876
2025 Integrative methylation profiling uncovers IL10RB hypomethylation as a mediator between environmental heavy metal exposure and lung cancer risk. Environmental pollution (Barking, Essex : 1987) 0 41397497

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