Affinage

HOXC13

Homeobox protein Hox-C13 · UniProt P31276

Length
330 aa
Mass
35.4 kDa
Annotated
2026-06-10
66 papers in source corpus 31 papers cited in narrative 31 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HOXC13 is a homeodomain transcription factor that serves as a master regulator of hair, nail, and filiform papilla development, with knockout animals from mice to pigs to frogs all displaying alopecia, brittle hair, and defective cornified appendages (PMID:9420327, PMID:28011715, PMID:38499530). It executes this program by binding sequence-specific cognate sites in the promoters of hair structural genes, directly activating some keratin-associated protein (KAP) and keratin genes while repressing others, and by negatively autoregulating its own promoter (PMID:15385554, PMID:30139327, PMID:11290294). HOXC13 sits atop a follicle differentiation cascade, directly activating the forkhead transcription factors FOXQ1 and FOXN1 through ChIP- and reporter-validated binding to coordinate medulla and terminal keratinocyte differentiation (PMID:16835220, PMID:21191399). Additional medulla-specific targets including Crisp1 and Soat1 are directly bound and regulated by HOXC13 (PMID:16382673, PMID:26321246), and its control of the hair cycle involves suppression of TGF-β1/p-Smad2 signaling to delay the anagen-to-catagen transition (PMID:26553656). Beyond its developmental role, HOXC13 associates with DNA replication complexes, co-localizing with early-S-phase replication foci and binding defined origins via its homeodomain (PMID:19182517), and physically interacts with the ETS factor PU.1/SPI1 to modulate hematopoietic gene expression (PMID:18076876, PMID:27506447). Its own expression is induced by estrogen via ERα/ERβ and MLL histone methyltransferases (PMID:19922474) and is constrained by upstream regulators including YAP/TEAD and Polycomb BMI-1 (PMID:25691658). Loss-of-function HOXC13 mutations—nonsense, frameshift, and homeodomain variants—cause autosomal-recessive pure hair and nail ectodermal dysplasia, acting through nonsense-mediated decay, cytoplasmic mislocalization, or loss of DNA-binding and target activation (PMID:23063621, PMID:23315978). In multiple cancers HOXC13 is co-opted as a pro-proliferative factor controlling cell-cycle and apoptotic targets (PMID:23495364, PMID:28979806, PMID:29168599).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 1998 High

    Established that HOXC13 is genetically essential for the development of hair, nails, and filiform papillae, defining its core biological role.

    Evidence Gene-targeted knockout mouse with phenotypic analysis

    PMID:9420327

    Open questions at the time
    • Did not identify direct transcriptional targets
    • No molecular mechanism for differentiation control
  2. 2001 High

    Linked HOXC13 dosage to hair keratin-associated protein gene expression and revealed negative autoregulation, showing it acts as a tunable transcriptional regulator of structural genes.

    Evidence Transgenic overexpression with DNA chip expression profiling and lacZ reporter

    PMID:11290294

    Open questions at the time
    • Direct vs indirect regulation of KAP genes not distinguished
    • Mechanism of autoregulation not mapped
  3. 2004 Medium

    Demonstrated that HOXC13 binds KAP gene promoters directly and sequence-specifically, converting correlative expression data into a direct regulatory relationship.

    Evidence EMSA on Krtap16 promoter sites

    PMID:15385554

    Open questions at the time
    • In vitro binding only
    • Activation vs repression output at native loci unresolved
  4. 2006 High

    Placed HOXC13 upstream of FOXQ1 in a medulla differentiation pathway, establishing it as an apical regulator of a downstream transcription factor cascade.

    Evidence Gene array, co-transfection reporter, ChIP, DNA binding

    PMID:16835220

    Open questions at the time
    • Cofactors mediating activation not identified
  5. 2005 Medium

    Showed HOXC13 functions without TALE cofactors MEIS/PREP in the follicle compartments where it activates early hair keratins, ruling out a canonical HOX cofactor requirement here.

    Evidence RT-PCR and immunolocalization of TALE proteins and HOXC13 in hair follicle

    PMID:16292560

    Open questions at the time
    • Alternative cofactors not identified
    • Negative localization finding only
  6. 2009 Medium

    Revealed a non-transcriptional role: HOXC13 associates with DNA replication complexes and origins through its homeodomain in a cell-cycle-dependent manner.

    Evidence Fluorescent fusion live imaging and ChIP at defined replication origins

    PMID:19182517

    Open questions at the time
    • Functional consequence for replication not demonstrated
    • Single lab
  7. 2009 High

    Identified estrogen/ER and MLL methyltransferases as upstream activators of HOXC13 transcription, embedding it in hormonal and chromatin-modifying control.

    Evidence ChIP, siRNA of ERα/ERβ/MLL1-4, promoter reporters

    PMID:19922474

    Open questions at the time
    • Physiological context of estrogen regulation unclear
    • Tissue specificity not addressed
  8. 2010 High

    Extended the regulatory cascade by showing HOXC13 directly activates FOXN1, connecting it to terminal keratinocyte differentiation programs.

    Evidence Microarray, co-transfection, ChIP, and Hoxc13/Foxn1 null mouse comparison

    PMID:21191399

    Open questions at the time
    • Full set of FOXN1-dependent effectors not mapped
  9. 2012 High

    Established HOXC13 as the causative gene for autosomal-recessive pure hair and nail ectodermal dysplasia, validating its essential human function.

    Evidence Whole-exome sequencing, RT-PCR, immunostaining in two families

    PMID:23063621

    Open questions at the time
    • Genotype-phenotype correlation across mutation types not yet defined
  10. 2013 Medium

    Showed a frameshift mutation causes cytoplasmic mislocalization and loss of target activation, establishing that nuclear localization is required for HOXC13 function.

    Evidence Sequencing plus localization and promoter reporter assays of mutant vs wild-type

    PMID:23315978

    Open questions at the time
    • NLS not precisely mapped
    • Single lab in vitro assay
  11. 2007 Medium

    Mapped a direct physical interaction between HOXC13 and PU.1/SPI1 with functional consequences for erythroid differentiation, revealing a hematopoietic role distinct from hair biology.

    Evidence Reciprocal interaction mapping, reporter assays, enforced expression in MEL cells

    PMID:18076876

    Open questions at the time
    • In vivo hematopoietic relevance limited
    • Single lab
  12. 2016 Medium

    Showed HOXC13 and SPI1 synergistically activate the proto-oncogene Zfp521, reinforcing the hematopoietic partnership with a defined transcriptional target.

    Evidence Co-transfection reporter, promoter deletion, transgenic mouse correlation

    PMID:27506447

    Open questions at the time
    • Direct binding at Zfp521 promoter by HOXC13 vs SPI1 not separated
  13. 2015 Medium

    Identified additional direct hair-medulla targets (Soat1) and an upstream YAP/TEAD axis controlling HOXC13 in epithelial progenitor proliferation, broadening its tissue regulatory network.

    Evidence ChIP and IHC for Soat1; RNA-Seq, ChIP, sphere assay in Yap mutant mice

    PMID:25691658 PMID:26321246

    Open questions at the time
    • Functional epistasis of YAP→HOXC13 not fully resolved
  14. 2015 Medium

    Demonstrated HOXC13 controls hair-cycle timing by suppressing TGF-β1/p-Smad2 signaling to delay catagen entry, adding a signaling-modulation function.

    Evidence shRNA knockdown, recombinant polypeptide injection, p-Smad2 immunostaining in vivo

    PMID:26553656

    Open questions at the time
    • Direct vs indirect effect on TGF-β1 pathway not established
  15. 2018 Medium

    Resolved that HOXC13 differentially activates and represses distinct keratin promoters and is positively regulated by LEF1, while homeodomain SNPs abolish regulatory function without changing protein levels.

    Evidence Dual-luciferase reporters in two cell types, promoter-GFP system, site-directed mutagenesis

    PMID:30139327

    Open questions at the time
    • Mechanism of bidirectional output at different promoters unknown
  16. 2021 Medium

    Confirmed conserved downstream targets (Foxn1, Krt85, Krt35) in an independent large-animal knockout, strengthening the cross-species HOXC13 follicle program.

    Evidence CRISPR/Cas9 knockout pig, RT-PCR, histology

    PMID:28011715

    Open questions at the time
    • No new mechanism beyond target confirmation
  17. 2017 Medium

    Implicated HOXC13 as a pro-survival, pro-proliferative factor in cancer through direct repression of CASP3 and control of cyclins, regulated by miR-503 and miR-141.

    Evidence ChIP, knockdown/overexpression, apoptosis and cell-cycle assays, 3'UTR luciferase

    PMID:28979806 PMID:29168599

    Open questions at the time
    • Whether oncogenic role uses the same DNA-binding logic as developmental targets unclear
  18. 2024 High

    Established the ancestral evolutionary depth of HOXC13's keratin-regulatory role by showing it controls hair keratin homolog expression and cornified claw formation in frogs with conserved binding sites.

    Evidence CRISPR/Cas9 knockout in X. tropicalis, expression analysis, promoter conservation

    PMID:38499530

    Open questions at the time
    • Conservation of the full downstream cascade across taxa not tested
  19. 2024 Medium

    Expanded HOXC13's roles to viral genome maintenance and tumor-immune modulation, and added genome-wide binding data plus new physical partner RHOXF2.

    Evidence CRISPR KO with HPV copy-number tracking; cGAS/STING immune profiling; ChIP-Seq; Co-IP/GST pulldown with rescue

    PMID:38057852 PMID:38381512 PMID:38697448 PMID:38914027

    Open questions at the time
    • Mechanism by which HOXC13 supports HPV genome maintenance unknown
    • Direct binding underlying immune effects not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HOXC13 selects between transcriptional activation and repression at different target promoters, and what cofactors substitute for canonical TALE proteins in follicle compartments, remains unresolved.
  • No structural model of HOXC13 bound to native target promoters
  • Activation/repression cofactor identity unknown
  • Connection between developmental and oncogenic target repertoires unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 5 GO:0140110 transcription regulator activity 5
Localization
GO:0005634 nucleus 3 GO:0000228 nuclear chromosome 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1640170 Cell Cycle 2 R-HSA-69306 DNA Replication 1
Partners
ESR1ESR2RHOXF2SPI1

Evidence

Reading pass · 31 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Hoxc13 null mice (generated by gene targeting) completely lack external hair (alopecia), have brittle hair, and show defects in nails and filiform papillae, establishing Hoxc13 as essential for hair, nail, and filiform papilla development. Gene targeting / loss-of-function knockout mouse with phenotypic readout Genes & development High 9420327
2001 Transgenic overexpression of Hoxc13 in differentiating keratinocytes causes alopecia and downregulation of a novel cluster of hair keratin-associated protein (KAP) genes on mouse chromosome 16; Hoxc13/lacZ reporter analysis indicates negative autoregulatory feedback control of Hoxc13 expression levels. Transgenic overexpression with large-scale differential gene expression analysis (DNA chip) and reporter gene assay Development (Cambridge, England) High 11290294
2004 HOXC13 directly binds to cognate sites in the promoters of Krtap16 KAP genes via sequence-specific protein-DNA interaction, supporting a regulatory relationship between Hoxc13 and these hair structural genes. Electrophoretic mobility shift assay (EMSA) / DNA binding assay The Journal of biological chemistry Medium 15385554
2005 HOXC13 binds at least one cognate site in the Crisp1 promoter (confirmed by EMSA), and Crisp1 is downregulated >20-fold in Hoxc13-overexpressing mice, establishing Crisp1 as a downstream regulatory target of Hoxc13 in the hair medulla. DNA chip expression analysis and EMSA (electrophoretic mobility shift assay) The journal of investigative dermatology. Symposium proceedings Medium 16382673
2005 HOXC13-controlled activation of early hair keratin genes hHa5 and hHa2 in hair follicles does not involve TALE proteins MEIS1, MEIS2, PREP1, or PREP2 as cofactors, because these proteins are exclusively cytoplasmically localized in the relevant follicle compartments where HOXC13 is nuclear. RT-PCR for TALE transcripts in hair follicle; immunolocalization of TALE proteins and HOXC13 in hair follicle sections Archives of dermatological research Medium 16292560
2006 HOXC13 directly binds Foxq1 gene regulatory regions and activates its transcription; Foxq1 and downstream medulla-specific genes are downregulated upon Hoxc13 overexpression, placing Hoxc13 upstream of Foxq1 in a pathway controlling hair medulla differentiation. Gene array analysis, co-transfection reporter assay, chromatin immunoprecipitation (ChIP), DNA binding studies The Journal of biological chemistry High 16835220
2007 HOXC13 physically interacts with the ETS domain of PU.1 (SPI1) through a region encompassing the C-terminal part of the homeodomain and the most C-terminal region of HOXC13, and enhances PU.1 transcriptional activity; enforced HOXC13 expression in MEL cells suppresses beta-globin expression and inhibits erythroid differentiation. Co-immunoprecipitation / protein interaction mapping, transcriptional reporter assays, enforced expression in MEL cells with beta-globin readout Experimental cell research Medium 18076876
2009 HOXC13 is a member of human DNA replication complexes: it co-localizes with replication foci in early-S-phase cells (driven by its homeodomain), binds the lamin B2 replication origin and origins near TOP1 and MCM4 genes in asynchronously growing cells by ChIP, but not in G0 resting cells. Fluorescent fusion-protein live imaging, ChIP analysis at specific replication origins Cell cycle (Georgetown, Tex.) Medium 19182517
2009 HOXC13 is transcriptionally activated by estrogen (17β-estradiol) via estrogen-response elements (ERE1, ERE2) in its promoter; ERα and ERβ are required for this activation; MLL1-MLL4 histone methylases are recruited to the HOXC13 promoter in an estrogen-dependent, ER-dependent manner, and MLL3 knockdown suppresses E2-induced HOXC13 activation. ChIP assay, knockdown (siRNA) of ERα, ERβ, MLL1-MLL4, promoter reporter assays The FEBS journal High 19922474
2010 HOXC13 directly activates Foxn1 transcription in hair follicles; Foxn1 is significantly downregulated in Hoxc13-null mice; co-transfection and ChIP assays confirm direct transcriptional control of Foxn1 by HOXC13, placing HOXC13 upstream of FOXN1 in a regulatory cascade controlling terminal differentiation markers in keratinocytes. DNA microarray, co-transfection reporter assay, ChIP, histological comparison of Hoxc13- and Foxn1-mutant mice The Journal of investigative dermatology High 21191399
2012 Loss-of-function mutations in HOXC13 (nonsense mutation c.390C>A / p.Tyr130* and homozygous microdeletion of exon 1) cause autosomal-recessive pure hair and nail ectodermal dysplasia in humans; dramatically reduced mRNA levels and nearly absent protein staining in hair follicles indicate nonsense-mediated mRNA decay as mechanism; four known HOXC13 target genes are markedly decreased in affected skin. Whole-exome sequencing, RT-PCR expression analysis, protein immunostaining in patient skin biopsies American journal of human genetics High 23063621
2012 Antisense oligonucleotide-mediated knockdown of HOXC13 induces cell cycle arrest (G1) and apoptosis in colon cancer cells, and reduces cyclin expression; overexpression of HOXC13 induces 3D colony formation in soft agar, demonstrating roles in cell proliferation and survival. Antisense oligonucleotide knockdown, cell viability assays, soft agar colony formation assay, flow cytometry RSC advances Medium 23495364
2013 A homozygous frameshift mutation in HOXC13 (c.355delC; p.Leu119Trpfs*20) causes protein mislocalization to the cytoplasm and failure to upregulate target gene promoter activities, establishing that correct nuclear localization of HOXC13 is required for its transcriptional function. Sequencing, expression studies in cultured cells (localization and promoter reporter assay of mutant vs wild-type HOXC13) Human mutation Medium 23315978
2015 YAP (Hippo pathway transcriptional coactivator) regulates Hoxc13 expression in oral, dental, and skin epithelial tissues; ChIP assay indicates YAP regulates Hoxc13 through TEAD transcription factors; Hoxc13 is functionally involved in YAP-regulated epithelial progenitor cell proliferation (sphere formation assay). RNA-Seq, real-time PCR, in situ hybridization, ChIP assay, sphere formation assay in Yap conditional KO and transgenic mice Molecular and cellular biology Medium 25691658
2015 Hoxc13 regulates the hair cycle: shRNA-mediated knockdown of Hoxc13 promotes premature catagen entry (shortened hair, increased apoptosis, inhibited proliferation), while recombinant Hoxc13 polypeptide injection prolongs anagen; mechanistically, p-Smad2 (active TGF-β1 signaling) is upregulated by Hoxc13 knockdown and downregulated by Hoxc13 injection, suggesting Hoxc13 blocks anagen-to-catagen transition by inhibiting TGF-β1 signaling. shRNA knockdown in vivo, recombinant polypeptide injection, TUNEL assay, proliferation markers, immunostaining for p-Smad2 Cell and tissue research Medium 26553656
2015 SOAT1 (sterol O-acyltransferase 1) is co-expressed with HOXC13 in the medulla of hair follicles; SOAT1 is absent from the defective medulla of Hoxc13-null mice; ChIP assay shows HOXC13 binding to the Soat1 upstream control region, supporting Soat1 as a downstream regulatory target of HOXC13. Immunohistochemistry, DNA microarray (prior data), ChIP assay Experimental and molecular pathology Medium 26321246
2016 HOXC13 and SPI1 (PU.1) synergistically and dose-dependently activate transcription of the proto-oncogene Zfp521 through specific regions of the Zfp521 promoter; this regulatory relationship is supported in vivo in transgenic mice overexpressing Hoxc13 in fetal liver, where Zfp521 expression correlates with Hoxc13 levels. Co-transfection reporter assay, promoter deletion analysis, transgenic mouse expression correlation Genesis (New York, N.Y. : 2000) Medium 27506447
2017 HOXC13 directly represses transcription of CASP3 by binding to the CASP3 promoter region (ChIP); HOXC13 knockdown upregulates CASP3 and induces apoptosis in ESCC cells; miR-503 directly targets the HOXC13 3'UTR to downregulate HOXC13. ChIP assay, knockdown experiments, luciferase reporter (miR-503 targeting), apoptosis assays Cancer science Medium 29168599
2017 HOXC13 knockdown induces G1-phase arrest in lung adenocarcinoma cells by downregulating CCND1 and CCNE1; conversely, HOXC13 overexpression promotes G1-to-S transition by upregulating CCND1 and CCNE1; miR-141 directly targets the HOXC13 3'UTR to suppress its expression. siRNA knockdown, overexpression, cell cycle analysis (flow cytometry), luciferase 3'UTR reporter assay American journal of cancer research Medium 28979806
2018 HOXC13 regulates keratin gene expression differentially: in cashmere goat dermal papilla cells, HOXC13 upregulates promoter activity of KRT84 and KRT38 but downregulates promoter activity of KRT1 and KRT2; two SNPs in the HOXC13 homeodomain (c.812A>G and c.929A>C) abolish its regulatory function on keratins without altering protein expression; HOXC13 negatively auto-regulates its own promoter; LEF1 positively regulates HOXC13 promoter activity. Dual-luciferase reporter assay in HEK293T and dermal papilla cells, promoter-GFP overexpression system, site-directed mutagenesis (SNP analysis) BMC genomics Medium 30139327
2010 BMI-1 knockdown (via shRNA) in HeLa cells leads to significant upregulation of HOXC13 mRNA, indicating that BMI-1 (Polycomb group) transcriptionally represses HOXC13 expression. shRNA-mediated knockdown of BMI-1, RT-PCR for HOXC13 mRNA Medical oncology (Northwood, London, England) Low 20661663
2021 In a mouse model of cerebral ischemia/reperfusion, LOC102640519 positively regulates HOXC13 expression (confirmed by ChIP assay showing LOC102640519's regulation of HOXC13), and elevated HOXC13 in turn negatively regulates ZO-1, Occludin, and Claudin-5 expression (confirmed by luciferase reporter and RNA pulldown), contributing to blood-brain-barrier disruption. ChIP assay, luciferase reporter assay, RNA pulldown, FISH, Western blot in MCAO mouse model and OGD/R cell model Experimental cell research Low 29842876
2023 Silencing HOXC13 in prostate cancer cells (22RV1 and DU145) induces DNA damage and activates the cGAS/STING/IRF3 pathway, upregulating IFN-β, CCL2, CCL5, and CXCL10 transcription; high HOXC13 expression suppresses γδ T cell and plasma cell infiltration and recruits M2 macrophages. siRNA knockdown, DNA damage assays, cGAS/STING pathway activation markers, immune infiltration analysis (CIBERSORT), qRT-PCR for immune factors Journal of translational medicine Medium 38057852
2023 HOXC13 directly binds the TIMM13 promoter and drives its transcription in osteosarcoma cells; HOXC13 silencing reduces TIMM13 expression, causing mitochondrial dysfunction (depolarization, ROS, ATP depletion, lipid peroxidation) and inhibiting Akt-mTOR signaling, proliferation, and migration. ChIP, HOXC13 silencing with TIMM13 expression readout, TIMM13 KO xenograft model, mitochondrial function assays, Akt-mTOR pathway markers Cell death & disease Medium 37407582
2023 HOXC13 positively regulates DNMT3A transcription in breast cancer cells (predicted by JASPAR database and confirmed by functional assays); HOXC13 knockdown reduces proliferation, migration, invasion, EMT, and glycolysis in BC cells. JASPAR binding site prediction, cell transfection (knockdown/OE), CCK-8, flow cytometry, Transwell, XF96 extracellular flux analyzer Experimental and therapeutic medicine Low 37614427
2023 ChIP-Seq in rabbit dermal papilla cells overexpressing HOXC13 identifies 9,670 genomic binding peaks; HOXC13 binds the PRKACB promoter region (−1596 to −1107 bp) and inhibits PRKACB transcription (confirmed by dual-luciferase reporter assay); PRKACB overexpression modulates BCL2, WNT2, LEF1, and SFRP2, inhibits DPC proliferation, and promotes apoptosis. ChIP-Seq, dual-luciferase reporter assay, RT-qPCR, CCK-8, flow cytometry Gene Medium 38381512
2024 HOXC13 is required for the stable maintenance of HPV16, HPV52, and HPV58 genomes in keratinocytes; CRISPR-Cas9 knockout of HOXC13 causes progressive loss of these viral genome copy numbers over passages, whereas HPV18 genome stability is HOXC13-independent. CRISPR-Cas9 KO of HOXC13 in NIKS cells, transfection of HPV genomes, quantitative copy number monitoring over cell passages Virology Medium 38914027
2024 Hoxc13 is required for the expression of hair keratin homologs in the cornified claws of Xenopus frogs; hoxc13 deletion abolishes hair keratin homolog expression and abrogates cornified claw development; Hoxc13 binding sites are conserved in the promoters of these keratin genes across amphibians and mammals, indicating an ancestral evolutionary role. CRISPR/Cas9 knockout of hoxc13 in X. tropicalis, gene expression analysis, promoter binding site conservation analysis Nature communications High 38499530
2024 A missense variant p.Arg311Trp in the homeobox domain of HOXC13 causes PHNED by decreasing HOXC13 protein stability (rather than altering DNA-binding affinity), as revealed by in vitro overexpression assays and computational structural modeling showing loss of interhelical connection between Arg311 (α-helix 3) and Glu276 (α-helix 1). In vitro overexpression assay (protein stability), in silico structural prediction, comparison with previously reported variants Human mutation Low 40225922
2021 In Hoxc13-null mice, expression of Foxn1, Krt85, and Krt35 is decreased, confirming these genes as downstream targets of HOXC13 in hair follicle differentiation; Hoxc13-null pigs show similar reductions in Foxn1, Krt85, and Krt35 expression, with absent normal hair and reduced/disarrayed follicles. CRISPR/Cas9 knockout pig generation, RT-PCR for target gene expression, histological analysis Human molecular genetics Medium 28011715
2024 RHOXF2 physically interacts with HOXC13 (confirmed by co-immunoprecipitation and GST pulldown); RHOXF2 knockdown suppresses HOXC13 expression; HOXC13 overexpression rescues the effects of RHOXF2 knockdown on TNBC cell proliferation, invasion, and Wnt2/β-catenin pathway activity. Co-immunoprecipitation, GST pulldown, overexpression/knockdown with rescue experiment, Wnt pathway markers Cellular signalling Medium 38697448

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Hoxc13 mutant mice lack external hair. Genes & development 214 9420327
2001 Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia. Development (Cambridge, England) 93 11290294
2010 The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. The Journal of investigative dermatology 58 21191399
2006 Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. The Journal of biological chemistry 58 16835220
2012 Loss-of-function mutations in HOXC13 cause pure hair and nail ectodermal dysplasia. American journal of human genetics 54 23063621
2003 Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13). Genes, chromosomes & cancer 49 12461755
2018 Long noncoding RNA HOXC13-AS positively affects cell proliferation and invasion in nasopharyngeal carcinoma via modulating miR-383-3p/HMGA2 axis. Journal of cellular physiology 43 30536950
2021 FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/β-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 42 34564982
2019 HOXC13-AS promotes breast cancer cell growth through regulating miR-497-5p/PTEN axis. Journal of cellular physiology 41 31066051
2018 Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling. Experimental cell research 39 29842876
2009 Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13. The FEBS journal 37 19922474
2015 YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues. Molecular and cellular biology 36 25691658
2004 Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. The Journal of biological chemistry 36 15385554
2017 HOXC13 promotes proliferation of lung adenocarcinoma via modulation of CCND1 and CCNE1. American journal of cancer research 34 28979806
2020 HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis. Oral oncology 31 32763778
2003 Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). Genes, chromosomes & cancer 30 12619167
2019 HOXC13-AS-miR-122-5p-SATB1-C-Myc feedback loop promotes migration, invasion and EMT process in glioma. OncoTargets and therapy 29 31564901
2004 Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role. Developmental biology 29 15385162
2018 The inconsistent regulation of HOXC13 on different keratins and the regulation mechanism on HOXC13 in cashmere goat (Capra hircus). BMC genomics 27 30139327
2017 HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of CASP3. Cancer science 27 29168599
2012 Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and induces apoptosis in tumor cells and over expression of HOXC13 induces 3D-colony formation. RSC advances 27 23495364
2009 The homeotic protein HOXC13 is a member of human DNA replication complexes. Cell cycle (Georgetown, Tex.) 27 19182517
2017 Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia-9. Human molecular genetics 25 28011715
2015 Hoxc13 is a crucial regulator of murine hair cycle. Cell and tissue research 25 26553656
2013 A homozygous frameshift mutation in the HOXC13 gene underlies pure hair and nail ectodermal dysplasia in a Syrian family. Human mutation 25 23315978
2021 HOXC13 promotes cervical cancer proliferation, invasion and Warburg effect through β-catenin/c-Myc signaling pathway. Journal of bioenergetics and biomembranes 20 34309767
2023 Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway. Journal of translational medicine 19 38057852
2018 The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 30125135
1999 Hair defects in Hoxc13 mutant mice. The journal of investigative dermatology. Symposium proceedings 18 10674376
2013 Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in well‑differentiated and dedifferentiated human liposarcomas. Oncology reports 17 24085196
2009 Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review. Cancer genetics and cytogenetics 17 19665070
2006 Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study. Journal of cutaneous pathology 17 16441405
2010 Knockdown of BMI-1 causes cell-cycle arrest and derepresses p16INK4a, HOXA9 and HOXC13 mRNA expression in HeLa cells. Medical oncology (Northwood, London, England) 16 20661663
2005 The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors. Archives of dermatological research 16 16292560
2005 Epididymal cysteine-rich secretory protein 1 encoding gene is expressed in murine hair follicles and downregulated in mice overexpressing Hoxc13. The journal of investigative dermatology. Symposium proceedings 16 16382673
2021 HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene. Cell cycle (Georgetown, Tex.) 14 33427025
2023 Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport. Cell death and differentiation 13 36869179
2023 HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth. Cell death & disease 13 37407582
2016 Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13. Genesis (New York, N.Y. : 2000) 13 27506447
2024 Evolutionary origin of Hoxc13-dependent skin appendages in amphibians. Nature communications 11 38499530
2024 M2 Macrophage exosomal HOXC13-AS in laryngeal cancer immunity via targeting miR-485-5p/IGF2BP2/PD-L1. International immunopharmacology 11 39126735
2017 A novel mutation in homeobox DNA binding domain of HOXC13 gene underlies pure hair and nail ectodermal dysplasia (ECTD9) in a Pakistani family. BMC medical genetics 9 28403827
2007 [Expression of HOXC13 in ameloblastoma]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 9 17331444
2007 Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells. Experimental cell research 9 18076876
2004 Structure and expression of the ovine Hoxc-13 gene. Gene 9 14960366
2017 A Novel Homozygous Missense Mutation in HOXC13 Leads to Autosomal Recessive Pure Hair and Nail Ectodermal Dysplasia. Pediatric dermatology 8 28297138
2010 [Hoxc13 and the development of hair follicle]. Yi chuan = Hereditas 8 20650845
2023 HOXC13 promotes cell proliferation, metastasis and glycolysis in breast cancer by regulating DNMT3A. Experimental and therapeutic medicine 7 37614427
2021 HOXC13-AS Induced Extracellular Matrix Loss via Targeting miR-497-5p/ADAMTS5 in Intervertebral Disc. Frontiers in molecular biosciences 7 34277699
2014 Expression analysis of KAP9.2 and Hoxc13 genes during different cashmere growth stages by qRT-PCR method. Molecular biology reports 7 24908288
2022 miR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit. Genes 5 35456485
2015 Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goats Breed. Anatomical record (Hoboken, N.J. : 2007) 5 26097036
2015 Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. Experimental and molecular pathology 5 26321246
2013 Adaptive evolution of Hoxc13 genes in the origin and diversification of the vertebrate integument. Journal of experimental zoology. Part B, Molecular and developmental evolution 5 25961277
2024 H3K27ac-induced RHOXF2 activates Wnt2/β-catenin pathway by binding to HOXC13 to aggravate the malignant progression of triple negative breast cancer. Cellular signalling 3 38697448
1994 Identification of the murine Hox-c12 and Hox-c13 homeoboxes on yeast artificial chromosomes. Genomics 3 7959778
2025 An immunotherapy guide constructed by cGAS-STING signature for breast cancer and the biofunction validation of the pivotal gene HOXC13 via in vitro experiments. Frontiers in immunology 2 40861477
2024 Molecular Genetic Characteristics of the Hoxc13 Gene and Association Analysis of Wool Traits. International journal of molecular sciences 2 38338874
2023 Variants Identified in the HOXC13 and HOXD13 Genes Suggest Association with Cervical Cancer in a Cohort of Mexican Women. Genes 2 36833285
2022 LncRNA HOXC-AS5 Affects the Proliferation, Invasion and Cell Cycle of Ameloblastoma Cells by Acting on the Target Gene HOXC13. Cellular and molecular biology (Noisy-le-Grand, France) 2 36029503
2017 HOXC13 and HSP27 Expression in Skin and the Periodic Growth of Secondary Fiber Follicles from Longdong Cashmere Goats Raised in Different Production Systems. Anatomical record (Hoboken, N.J. : 2007) 2 29149771
2024 Homozygous HOXC13 Variant Causes Pure Hair and Nail Ectodermal Dysplasia via Reduction in Protein Stability. Human mutation 1 40225922
2023 ChIP-Seq analysis reveals PRKACB as a target gene of HOXC13 involved in rabbit hair follicle development. Gene 1 38381512
2021 Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Experimental dermatology 1 34657330
2025 Correlation Analysis of CXCL10, FOS, HOXC13, and WNT4 Gene Polymorphisms with Key Economic Traits-Initial Population Screening for Jiangnan Cashmere Goats. Genes 0 41010042
2024 Differential requirement of the transcription factor HOXC13 for the stable maintenance of human papillomavirus genome among high-risk genotypes. Virology 0 38914027

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