Affinage

HERC1

Probable E3 ubiquitin-protein ligase HERC1 · UniProt Q15751

Length
4861 aa
Mass
532.2 kDa
Annotated
2026-06-10
34 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HERC1 is a giant multidomain protein that couples guanine-nucleotide exchange activity to HECT-domain E3 ubiquitin ligase function, governing membrane trafficking, growth signaling, and neuronal homeostasis (PMID:8861955, PMID:30140388). Through its N-terminal RCC1-like domain it acts as a guanine-nucleotide exchange factor that stimulates GDP release from ARF1, ARF6, and Rab GTPases at the cytosol and Golgi, an activity that strictly requires PI(4,5)P2 bound to the RLD (PMID:8861955, PMID:15642342). As an E3 ligase, HERC1 targets multiple substrates for K48-linked polyubiquitination and proteasomal degradation: it destabilizes C-RAF to restrain ERK and MKK3/p38 signaling, thereby limiting cell proliferation, migration, and promoting ferroptosis (PMID:30140388, PMID:31965002, PMID:39983667); it destabilizes TSC2 in a manner blocked by TSC1 binding, linking HERC1 to mTORC1 regulation and autophagy (PMID:16464865, PMID:32921582); and it degrades additional substrates including NCOA4, KAT2A, and deoxycytidine kinase to modulate ferritinophagy, PI3K/AKT signaling, and chemosensitivity (PMID:39216271, PMID:41567019, PMID:39093953). In neurons, HERC1 is essential for presynaptic vesicle recycling, neuromuscular junction structure and neurotransmitter release, and axonal myelination, acting through autophagy rather than proteasomal control at the synapse (PMID:25746226, PMID:32694577, PMID:39859507). A missense mutation in the RLD causes Purkinje cell degeneration via excessive autophagy in tambaleante mice, and human HERC1 HECT-domain mutation causes mTORC1 hyperactivation with intellectual disability (PMID:20041218, PMID:32921582).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1996 High

    Established HERC1 as a Golgi/cytosolic guanine-nucleotide exchange factor, defining its first molecular activity through its RCC1-like domains acting on ARF and Rab GTPases.

    Evidence Subcellular fractionation, immunofluorescence with Brefeldin A, and in vitro GEF assays with recombinant domains

    PMID:8861955

    Open questions at the time
    • Did not connect GEF activity to a downstream trafficking pathway
    • E3 ligase function not yet known
  2. 2003 Medium

    Tested whether the HECT domain has substrate roles beyond ubiquitination by identifying an M2-PK interaction, but found no functional consequence.

    Evidence Co-IP, recombinant HECT pulldown, and colocalization

    PMID:12650930

    Open questions at the time
    • No ubiquitination or activity change observed
    • Functional significance of the interaction unresolved
  3. 2005 High

    Defined the biochemical regulation of HERC1 GEF activity, showing it requires PI(4,5)P2 and modulates ARF6 nucleotide exchange.

    Evidence In vitro nucleotide exchange and lipid co-purification assays with recombinant RLD1

    PMID:15642342

    Open questions at the time
    • Cellular context for PI(4,5)P2-dependent GEF activity not established
    • Relationship to E3 ligase function unclear
  4. 2006 High

    Revealed HERC1 as an E3 ligase that destabilizes TSC2, with TSC1 binding protecting TSC2, linking HERC1 to mTOR pathway control.

    Evidence Reciprocal Co-IP, pulldown, and protein stability assays with WT and mutant TSC2

    PMID:16464865

    Open questions at the time
    • Direct in vitro ubiquitylation of TSC2 not reconstituted
    • Physiological consequence on mTORC1 output not measured here
  5. 2009 High

    Demonstrated HERC1 is causally required for Purkinje cell survival, linking an RLD mutation to autophagy-driven neurodegeneration in vivo.

    Evidence Positional cloning and transgenic rescue in tambaleante mice with pathway Western blots

    PMID:20041218

    Open questions at the time
    • Mechanism linking RLD mutation to excess autophagy not resolved
    • Whether the mutation is gain- or loss-of-function ambiguous
  6. 2014 High

    Identified activated BAK as a HERC1 substrate co-opted by HPV5 E6, extending HERC1 ligase activity into apoptotic regulation.

    Evidence siRNA screen, Co-IP in E6/UV-treated cells, BAK lysine and HERC1 BH3-domain mutagenesis

    PMID:25408501

    Open questions at the time
    • Whether HERC1 targets BAK outside HPV E6 context unknown
    • Direct in vitro ubiquitylation not shown
  7. 2018 High

    Established C-RAF as a direct HERC1 substrate degraded via K48 ubiquitination, defining a node controlling ERK signaling and proliferation.

    Evidence Reciprocal Co-IP, in vitro ubiquitylation, linkage-specific ubiquitin detection, RAF inhibitor and siRNA epistasis

    PMID:30140388

    Open questions at the time
    • Recruitment mechanism for C-RAF not defined
    • Regulation of HERC1-C-RAF interaction unknown
  8. 2018 Medium

    Extended HERC1 neuronal function to myelin integrity and axon conduction, implicating Akt2 dysregulation in peripheral nerve pathology.

    Evidence Nerve conduction, electron microscopy, and pAkt2 Western blot in tambaleante sciatic nerve

    PMID:29603094

    Open questions at the time
    • Substrate driving myelin/Akt2 changes not identified
    • Schwann-cell-autonomous vs neuronal contribution unresolved
  9. 2020 High

    Connected HERC1-mediated C-RAF degradation to cell migration through a RAF-dependent MKK3/p38 transcriptional axis.

    Evidence siRNA, in vitro ubiquitylation, RAF inhibition epistasis, MKK3 qRT-PCR, and migration assays

    PMID:31965002

    Open questions at the time
    • Mechanism by which C-RAF raises MKK3 mRNA not defined
    • In vivo relevance of migration phenotype untested here
  10. 2020 Medium

    Linked a human HECT-domain mutation to mTORC1 hyperactivation and impaired starvation-induced autophagy, establishing disease relevance.

    Evidence Patient fibroblast assays under starvation with pS6K1 and autophagy marker Western blots

    PMID:32921582

    Open questions at the time
    • Whether mutation acts through TSC2 not directly tested
    • Single patient-derived material
  11. 2020 Medium

    Defined HERC1's presynaptic role in vesicle recycling and active zone structure at central synapses.

    Evidence TEM, FM1-43 destaining, and immunocytochemistry in tambaleante hippocampal neurons

    PMID:32694577

    Open questions at the time
    • Molecular substrate at the presynapse not identified
    • Loss-of-function vs mutant gain-of-function not distinguished
  12. 2021 Low

    Reported HERC1 association with and tyrosine phosphorylation by BCR-ABL1, hinting at regulation in CML.

    Evidence Co-IP and phosphorylation assay in CML cell lines

    PMID:33477751

    Open questions at the time
    • Single Co-IP without phosphosite mapping or reconstitution
    • Functional consequence of phosphorylation unknown
  13. 2023 Medium

    Showed HERC1 controls bone remodeling via C-RAF/ERK/p38 in mesenchymal cells, extending the C-RAF axis to skeletal biology.

    Evidence Herc1-knockout mice, MSC osteogenic differentiation, bone histomorphometry, and RANKL/OPG expression

    PMID:36635269

    Open questions at the time
    • Cell-autonomous osteoclast vs osteoblast contributions unresolved
    • Direct ubiquitylation in bone cells not reconstituted
  14. 2024 Medium

    Identified NCOA4 as a HERC1 substrate, coupling HERC1 to ferritinophagy and ferroptosis regulation.

    Evidence Co-IP, ubiquitination assay, and ferroptosis readouts in osteosarcoma cells

    PMID:39216271

    Open questions at the time
    • NRF2 upstream link only correlative
    • Direct in vitro ubiquitylation of NCOA4 not shown
  15. 2024 Medium

    Discovered HERC1 degrades deoxycytidine kinase, defining a pharmacogenomic determinant of cytarabine response in AML.

    Evidence Genome-wide CRISPR screen, in vivo AML models, and quantitative proteomics

    PMID:39093953

    Open questions at the time
    • Substrate relationship inferred from proteomics, not reconstituted in vitro
    • Mechanism of dCK recognition unknown
  16. 2025 Medium

    Distinguished HERC1's neuromuscular role as autophagy-dependent rather than proteasome-dependent, refining its synaptic mechanism.

    Evidence Proteasome activity assays, MG-132 and wortmannin pharmacology, and autophagy/vesicle marker Western blots at the NMJ

    PMID:39859507

    Open questions at the time
    • Substrate driving autophagy regulation at synapse not identified
    • Tissue specificity of autophagy dependence unclear
  17. 2025 Medium

    Identified KAT2A as a HERC1 substrate, connecting HERC1 to PI3K/AKT signaling and chemoresistance via PIK3CB acetylation.

    Evidence Co-IP, ubiquitination assay, knockdown/overexpression rescue, and xenografts in lung cancer cells

    PMID:41567019

    Open questions at the time
    • Direct in vitro ubiquitylation of KAT2A not reconstituted
    • Generality beyond gemcitabine resistance untested
  18. 2025 Medium

    Confirmed the HERC1-C-RAF axis drives ferroptosis in lung adenocarcinoma, reinforcing C-RAF as a central effector.

    Evidence Co-IP, ubiquitination and stability assays, ferroptosis markers, and C-RAF rescue

    PMID:39983667

    Open questions at the time
    • Link between C-RAF stability and ferroptosis effectors not detailed
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HERC1's GEF activity, multiple ubiquitination substrates, and giant scaffold architecture are coordinated into a unified regulatory logic, and how distinct mutations produce opposing mTORC1 outcomes, remains unresolved.
  • No structural model integrating RLD and HECT domains
  • Substrate selection rules across contexts undefined
  • Gain- vs loss-of-function basis of different disease mutations unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 7 GO:0016874 ligase activity 3 GO:0098772 molecular function regulator activity 2 GO:0008289 lipid binding 1
Localization
GO:0005794 Golgi apparatus 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-112316 Neuronal System 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-9612973 Autophagy 3
Partners
ARF1ARF6BAK1KAT2ANCOA4RAF1TSC2

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 HERC1 (p619) localizes to the cytosol and Golgi apparatus in a Brefeldin A-sensitive manner; its N-terminal RCC1-like domain (RLD1) stimulates guanine nucleotide exchange on ARF1 and Rab proteins but not on Ran or R-Ras2/TC21; its C-terminal RCC1-like domain interacts specifically with myristoylated ARF1. Subcellular fractionation, immunofluorescence, Brefeldin A treatment, in vitro GEF assay with purified recombinant domains The EMBO journal High 8861955
2003 The HECT domain of HERC1 physically interacts with M2-type pyruvate kinase (M2-PK); this interaction does not induce M2-PK ubiquitination nor affect its enzymatic activity. Co-immunoprecipitation, pulldown with recombinant HECT domain, immunofluorescence colocalization FEBS letters Medium 12650930
2004 HERC1 is recruited to ARF6-induced, aluminum fluoride-stimulated actin-rich surface protrusions in HeLa cells; HERC1 overexpression alone does not stimulate protrusion formation, indicating its recruitment is downstream of ARF6 activation rather than HERC1 acting as an ARF6-GEF in this context. A phosphoinositide-binding mechanism was proposed for translocation. Immunofluorescence of transfected HeLa cells treated with AlF4⁻, overexpression experiments FEBS letters Low 14960311
2005 HERC1 RLD1 stimulates GDP release from ARF6 but inhibits GDP/GTP exchange under conditions where ARNO promotes it; HERC1's GEF activity requires phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) bound to RLD1, and purified HERC1 contains PI(4,5)P2 co-purifying with RLD1. In vitro guanine nucleotide exchange assay with purified recombinant RLD1, lipid co-purification/binding assay FEBS letters High 15642342
2006 HERC1 interacts with TSC2 and functions as an E3 ubiquitin ligase that destabilizes TSC2; TSC1 binding to TSC2 sterically excludes HERC1 from the TSC2 complex, thereby stabilizing TSC2. Disease-causing TSC2 mutations allow HERC1 binding even in the presence of TSC1. Co-immunoprecipitation, pulldown assays, protein stability assays with wild-type and mutant TSC2 The Journal of biological chemistry High 16464865
2009 A missense mutation Gly483Glu in the N-terminal RCC1-like domain of HERC1 causes progressive Purkinje cell degeneration in tambaleante mice via extensive autophagy, accompanied by increased mutant HERC1 protein levels and decreased mTOR activity; transgenic rescue with wild-type Herc1 BAC or human HERC1 cDNA validated the causal role. Positional cloning, transgenic rescue, histology, Western blot for mTOR pathway components, autophagy markers PLoS genetics High 20041218
2014 HPV5 E6 recruits HERC1 to ubiquitinate and degrade activated BAK (after UV-induced conformational change and phosphorylation); HERC1 physically interacts with activated BAK via a putative BH3-like domain in HERC1, and a specific lysine on BAK is required for E6-mediated proteolysis. siRNA functional screen, co-immunoprecipitation in E6-expressing UV-treated cells, site-directed mutagenesis of BAK lysine residue, domain analysis International journal of cancer High 25408501
2015 HERC1 E3 ubiquitin ligase is required for normal neuromuscular junction morphology and evoked neurotransmitter release; the tambaleante HERC1 mutation reduces motor end-plate area and impairs presynaptic vesicle release before cerebellar degeneration occurs. Electrophysiology (evoked neurotransmitter release), morphometry of motor end-plates, in vivo motor function assays in tambaleante mice Cellular and molecular life sciences : CMLS Medium 25746226
2018 HERC1 controls C-RAF protein stability by promoting its K48-linked polyubiquitination and proteasomal degradation; HERC1 directly interacts with C-RAF as shown by Co-IP and pulldown; in vitro ubiquitylation assay confirms C-RAF is a direct substrate of HERC1. HERC1 knockdown increases ERK phosphorylation and cell proliferation via C-RAF stabilization. Co-immunoprecipitation, pulldown, confocal microscopy, in vitro ubiquitylation assay, pharmacological RAF inhibitors, siRNA, K48-linkage-specific ubiquitin detection Oncotarget High 30140388
2018 HERC1 mutation in tambaleante mice causes compact myelin damage (tomacula, hypermyelination foci) in motor axons, delays action potential propagation, and alters terminal Schwann cells at the NMJ, associated with increased phospho-Akt2 in sciatic nerve. Electrophysiology (nerve conduction velocity), electron microscopy, immunohistochemistry, Western blot for pAkt2 in sciatic nerve of tambaleante mice Molecular neurobiology Medium 29603094
2020 HERC1 regulates cell migration through the MKK3/p38 pathway in a RAF-dependent manner: HERC1 ubiquitylates C-RAF for proteasomal degradation; C-RAF stabilization then increases MKK3 mRNA levels, which activates p38 to drive migration. HERC1 knockdown induces C-RAF accumulation, MKK3 upregulation, and p38 phosphorylation. siRNA knockdown, in vitro ubiquitylation assay, RAF pharmacological inhibitors, qRT-PCR for MKK3 mRNA, migration assays, Western blot for p38 phosphorylation Scientific reports High 31965002
2020 HERC1 mutation (gain-of-function, Arg4691Pro in HECT domain) causes mTORC1 hyperactivation and failure to suppress mTORC1 during nutrient starvation (catabolic state), with abnormally high S6K1 phosphorylation and reduced autophagy in patient fibroblasts. Patient fibroblast functional assay under nutrient starvation, Western blot for pS6K1, autophagy markers (LC3, p62) Molecular genetics and metabolism Medium 32921582
2020 HERC1 mutation in tambaleante hippocampal neurons reduces synaptic vesicle number, decreases active zone size, reduces clathrin immunoreactivity, and increases endosomes and autophagosomes at presynaptic endings, demonstrating HERC1's role in presynaptic membrane dynamics. Transmission electron microscopy, FM1-43 destaining assay, immunocytochemistry in cultured hippocampal neurons from tambaleante mice Scientific reports Medium 32694577
2021 HERC1 physically interacts with BCR-ABL1 fusion protein in CML cells and is directly tyrosine-phosphorylated by ABL kinase. Co-immunoprecipitation, phosphorylation assay in CML cell lines Cancers Low 33477751
2023 HERC1 regulates osteoblastogenesis and osteoclastogenesis; its depletion increases C-RAF levels and phosphorylated ERK and p38 during osteogenic differentiation of mesenchymal stem cells, and Herc1-knockout mice develop osteopenia with increased osteoclast numbers in young females and elevated Rankl/Opg ratio in osteocytes. Herc1-knockout mouse model, osteogenic differentiation of MSCs, Western blot for C-RAF/pERK/pp38, bone histomorphometry, RANKL/OPG gene expression Cell death & disease Medium 36635269
2024 HERC1 ubiquitinates and degrades NCOA4 (a cargo receptor for ferritinophagy); targeting the HERC1-NCOA4 axis during photodynamic therapy activates ferroptosis in osteosarcoma cells. NRF2 is identified as a potential upstream regulator of this axis. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown, cell death assays in osteosarcoma cell lines Redox biology Medium 39216271
2024 HERC1 ubiquitinates deoxycytidine kinase (dCK) for degradation in AML cells; loss of HERC1 enhances Ara-C (cytarabine)-induced cell death by compromising cell cycle progression. This was identified by genome-wide CRISPR pharmacogenomic screening and validated by proteomic analysis. Genome-wide CRISPR screen, in vitro and in vivo AML models, quantitative proteomics, validation of dCK as HERC1 substrate Blood advances Medium 39093953
2025 HERC1 mutation in tambaleante mice does not alter proteasomal activity or specific UPS gene expression in brain or muscle tissue; proteasome inhibition with MG-132 does not affect evoked neurotransmitter release, whereas autophagy inhibition with wortmannin impairs it. HERC1 mutation increases p62 expression in muscle and alters clathrin and synaptophysin levels, indicating HERC1 regulates autophagy and vesicular recycling but not proteasomal function at the NMJ. Proteasome activity assay, MG-132 and wortmannin pharmacology at the NMJ, Western blot for p62/clathrin/synaptophysin in tambaleante mice International journal of molecular sciences Medium 39859507
2025 HERC1 promotes ubiquitination and proteasomal degradation of KAT2A (a lysine acetyltransferase); KAT2A depletion inhibits lysine acetylation of PIK3CB, inactivating the PI3K/AKT axis and suppressing autophagy, thereby enhancing gemcitabine sensitivity in lung cancer cells. Co-immunoprecipitation, ubiquitination assay, overexpression/knockdown in gemcitabine-resistant lung cancer cells, xenograft model, Western blot for PI3K/AKT pathway Neoplasma Medium 41567019
2025 HERC1 interacts with C-RAF, promotes its polyubiquitination, accelerates its proteasomal degradation, and promotes ferroptosis in lung adenocarcinoma cells; C-RAF overexpression partially rescues the ferroptosis phenotype induced by HERC1 overexpression. Co-immunoprecipitation, ubiquitination assay, protein stability assay, ferroptosis markers (ROS, MDA, GSH, Fe2+), CCK-8/LDH assays, rescue by C-RAF overexpression Cancer genetics Medium 39983667

Source papers

Stage 0 corpus · 34 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. The Journal of biological chemistry 186 16464865
1996 p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. The EMBO journal 117 8861955
2009 Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase. PLoS genetics 55 20041218
2005 Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene. Cell death and differentiation 50 15592436
2015 A nonsense variant in HERC1 is associated with intellectual disability, megalencephaly, thick corpus callosum and cerebellar atrophy. European journal of human genetics : EJHG 44 26153217
2017 HERC1 mutations in idiopathic intellectual disability. European journal of medical genetics 40 28323226
2015 Biallelic HERC1 mutations in a syndromic form of overgrowth and intellectual disability. Clinical genetics 38 26138117
2015 The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction. Cellular and molecular life sciences : CMLS 37 25746226
2014 Resistance to UV-induced apoptosis by β-HPV5 E6 involves targeting of activated BAK for proteolysis by recruitment of the HERC1 ubiquitin ligase. International journal of cancer 35 25408501
2003 Interaction between HERC1 and M2-type pyruvate kinase. FEBS letters 35 12650930
2016 A splice site mutation in HERC1 leads to syndromic intellectual disability with macrocephaly and facial dysmorphism: Further delineation of the phenotypic spectrum. American journal of medical genetics. Part A 32 27108999
2018 The E3 ubiquitin ligase HERC1 controls the ERK signaling pathway targeting C-RAF for degradation. Oncotarget 31 30140388
2020 The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling. Scientific reports 20 31965002
2013 Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure. PloS one 16 24312201
2020 The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses. Scientific reports 15 32694577
2020 HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory. Frontiers in neuroanatomy 15 33328904
2018 HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System. Molecular neurobiology 15 29603094
2021 HERC1 Regulates Breast Cancer Cells Migration and Invasion. Cancers 14 33804079
2005 Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins. FEBS letters 13 15642342
2024 Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma. Redox biology 12 39216271
2022 The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation. Journal of clinical medicine 11 35054018
2021 The Giant HECT E3 Ubiquitin Ligase HERC1 Is Aberrantly Expressed in Myeloid Related Disorders and It Is a Novel BCR-ABL1 Binding Partner. Cancers 10 33477751
2020 A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism. Molecular genetics and metabolism 10 32921582
2004 The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells. FEBS letters 9 14960311
2023 HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Cell death & disease 7 36635269
2022 Transcriptome-wide association study of HIV-1 acquisition identifies HERC1 as a susceptibility gene. iScience 5 36034232
2022 The Herc1 gene in neurobiology. Gene 4 34990797
2009 HERC1 polymorphisms: population-specific variations in haplotype composition. Cell biochemistry and function 3 19618402
2024 The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia. Blood advances 2 39093953
2025 HERC1 E3 Ubiquitin Ligase Is Necessary for Autophagy Processes and for the Maintenance and Homeostasis of Vesicles in Motor Nerve Terminals, but Not for Proteasomal Activity. International journal of molecular sciences 1 39859507
2024 First Case of Macrocephaly, Dysmorphic Facies, and Psychomotor Retardation Harboring Co-inherited Variants in HERC1 and PMP22 Genes from Iran: Two Novel Variants. Archives of Iranian medicine 1 39891458
2026 HERC1 oncogene enhances stemness and tumorigenic potential in CD44+-derived organoids of head and neck squamous cell carcinoma through IL-6/STAT3 signaling. Oncogene 0 41965446
2025 The mechanism of E3 ubiquitin ligase HERC1 regulating ferroptosis in lung adenocarcinoma cells. Cancer genetics 0 39983667
2025 HERC1 attenuates gemcitabine resistance of lung cancer cells by inhibiting autophagy through KAT2A ubiquitination. Neoplasma 0 41567019

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