- Length
- 364 aa
- Mass
- 39.2 kDa
- Annotated
- 2026-06-14
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2007 | TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. | Immunity | 536 | 18082433 |
| 2011 | Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. | The Journal of clinical investigation | 393 | 21821911 |
| 2011 | T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. | Proceedings of the National Academy of Sciences of the United States of America | 315 | 21536871 |
| 2005 | TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. | Nature immunology | 295 | 15793576 |
| 2005 | TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. | Nature immunology | 266 | 15793575 |
| 2018 | Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1+ regulatory B cell expansion. | Journal for immunotherapy of cancer | 247 | 30526680 |
| 2013 | Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. | Journal of virology | 216 | 23698310 |
| 2004 | T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. | Journal of immunology (Baltimore, Md. : 1950) | 189 | 15153541 |
| 1998 | The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. | Journal of virology | 174 | 9658108 |
| 2007 | TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. | Blood | 146 | 17620455 |
| 2003 | Chromosome cohesion is regulated by a clock gene paralogue TIM-1. | Nature | 139 | 12827206 |
| 2012 | Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. | Proceedings of the National Academy of Sciences of the United States of America | 121 | 22773818 |
| 2005 | T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. | Proceedings of the National Academy of Sciences of the United States of America | 118 | 16284246 |
| 2007 | Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. | The Journal of experimental medicine | 115 | 17606630 |
| 2015 | Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation. | Journal of immunology (Baltimore, Md. : 1950) | 114 | 25582854 |
| 2003 | TIM-1, a novel allergy and asthma susceptibility gene. | Springer seminars in immunopathology | 107 | 15007635 |
| 2008 | Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. | The Journal of clinical investigation | 104 | 18079964 |
| 2013 | Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). | Food chemistry | 101 | 24001852 |
| 2017 | Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm. | mBio | 99 | 28951472 |
| 2018 | TIM-1 Ubiquitination Mediates Dengue Virus Entry. | Cell reports | 94 | 29742433 |
| 2012 | Anti-CD45RB/anti-TIM-1-induced tolerance requires regulatory B cells. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 93 | 22494812 |
| 2008 | Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. | The Journal of allergy and clinical immunology | 91 | 18547633 |
| 2017 | TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients. | Arthritis research & therapy | 88 | 28103916 |
| 2015 | KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation. | The EMBO journal | 83 | 26282792 |
| 2015 | TIM-1 signaling is required for maintenance and induction of regulatory B cells. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 79 | 25645598 |
| 2014 | HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome. | Cancer research | 75 | 24390735 |
| 2018 | TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus. | Journal of virology | 68 | 29875238 |
| 2017 | TIM1 (HAVCR1) Is Not Essential for Cellular Entry of Either Quasi-enveloped or Naked Hepatitis A Virions. | mBio | 68 | 28874468 |
| 2015 | Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus. | Journal of virology | 67 | 25855742 |
| 2007 | Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses. | Journal of immunology (Baltimore, Md. : 1950) | 66 | 17277130 |
| 2007 | Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals. | Journal of immunology (Baltimore, Md. : 1950) | 66 | 17371991 |
| 2021 | Regulatory B cells: TIM-1, transplant tolerance, and rejection. | Immunological reviews | 65 | 33484008 |
| 2008 | Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients. | Scandinavian journal of immunology | 65 | 18052965 |
| 2012 | Kim-1/Tim-1 and immune cells: shifting sands. | Kidney international | 64 | 22499138 |
| 2005 | Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. | Developmental cell | 63 | 15691769 |
| 2008 | TIM-1 and TIM-3 proteins in immune regulation. | Cytokine | 62 | 18706830 |
| 2018 | Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis. | Glia | 61 | 29457657 |
| 2014 | TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. | Immunity | 61 | 24703780 |
| 2020 | Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. | Cell reports | 56 | 32668241 |
| 2020 | Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection. | Nature microbiology | 54 | 32541946 |
| 2009 | Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. | Proceedings of the National Academy of Sciences of the United States of America | 54 | 19528638 |
| 2022 | KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. | medRxiv : the preprint server for health sciences | 53 | 32995803 |
| 2016 | Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. | Arteriosclerosis, thrombosis, and vascular biology | 52 | 26821944 |
| 2011 | The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury. | Journal of the American Society of Nephrology : JASN | 50 | 21355054 |
| 2011 | Novel roles for TIM-1 in immunity and infection. | Immunology letters | 50 | 21911007 |
| 2003 | Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma. | Human immunology | 49 | 14630400 |
| 2012 | Identification of amino acids important for binding of Clostridium perfringens epsilon toxin to host cells and to HAVCR1. | Biochemistry | 48 | 22938730 |
| 2018 | TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection. | Viruses | 47 | 30441759 |
| 2022 | TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway. | BMC cancer | 46 | 35392845 |
| 2011 | Tim-1 promotes cisplatin nephrotoxicity. | American journal of physiology. Renal physiology | 45 | 21835770 |
| 2020 | Gastrointestinal digestion of dietary advanced glycation endproducts using an in vitro model of the gastrointestinal tract (TIM-1). | Food & function | 44 | 32602872 |
| 2011 | Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. | European journal of immunology | 44 | 21469101 |
| 2004 | The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population. | Immunogenetics | 44 | 15565336 |
| 2019 | TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis. | PLoS neglected tropical diseases | 42 | 31242184 |
| 2015 | TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope. | Protein & cell | 42 | 26487564 |
| 2012 | Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons | 40 | 23137033 |
| 2010 | Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response. | Immunology | 40 | 20518819 |
| 2021 | The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry. | Cells | 39 | 34359995 |
| 2010 | Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. | The Journal of clinical investigation | 39 | 20628202 |
| 2021 | Altered Tim-1 and IL-10 Expression in Regulatory B Cell Subsets in Type 1 Diabetes. | Frontiers in immunology | 38 | 35754999 |
| 2017 | Bacillus coagulans GBI-30, 6086 increases plant protein digestion in a dynamic, computer-controlled in vitro model of the small intestine (TIM-1). | Beneficial microbes | 37 | 28504581 |
| 2016 | Development of a Novel Antibody-Drug Conjugate for the Potential Treatment of Ovarian, Lung, and Renal Cell Carcinoma Expressing TIM-1. | Molecular cancer therapeutics | 36 | 27671527 |
| 2017 | TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection. | Journal of virology | 35 | 27807228 |
| 2013 | Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine. | Biochimica et biophysica acta | 35 | 24286866 |
| 2011 | Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. | Kidney international | 35 | 22205357 |
| 2004 | The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population. | Biochemical and biophysical research communications | 35 | 14985107 |
| 2022 | Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. | Nature communications | 34 | 35660734 |
| 2007 | Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. | Journal of virology | 33 | 17229699 |
| 2016 | Immune Regulation and Antitumor Effect of TIM-1. | Journal of immunology research | 30 | 27413764 |
| 2009 | Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. | Journal of immunology (Baltimore, Md. : 1950) | 29 | 19155484 |
| 2005 | Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein. | Genes and immunity | 28 | 15889130 |
| 2005 | Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. | Journal of neuroimmunology | 28 | 15913792 |
| 2010 | Association between TIM-1 gene polymorphisms and allergic rhinitis in a Han Chinese population. | Journal of investigational allergology & clinical immunology | 26 | 20232767 |
| 2019 | TIM-1 As a Signal Receptor Triggers Dengue Virus-Induced Autophagy. | International journal of molecular sciences | 25 | 31581681 |
| 2012 | Tim-1 regulates Th2 responses in an airway hypersensitivity model. | European journal of immunology | 23 | 22144095 |
| 2007 | A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population. | International archives of allergy and immunology | 23 | 17570927 |
| 2012 | Polymorphisms of the TIM-1 gene are associated with rheumatoid arthritis in the Chinese Hui minority ethnic population. | Genetics and molecular research : GMR | 22 | 22290466 |
| 2007 | Expression of T-cell immunoglobulin- and mucin-domain-containing molecule-1 (TIM-1) is increased in a mouse model of asthma and relationship to GATA-3. | Life sciences | 22 | 18234236 |
| 2006 | Antibodies to T-cell Ig and mucin domain-containing proteins (Tim)-1 and -3 suppress the induction and progression of murine allergic conjunctivitis. | Biochemical and biophysical research communications | 22 | 17174273 |
| 2022 | miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections. | International journal of molecular sciences | 21 | 36142146 |
| 2017 | Tim-1+ B cells suppress T cell interferon-gamma production and promote Foxp3 expression, but have impaired regulatory function in coronary artery disease. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica | 21 | 28736945 |
| 2006 | TIM-1 regulates macrophage cytokine production and B7 family member expression. | Immunology letters | 21 | 17161870 |
| 2018 | Association between the TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy. | Bioscience reports | 20 | 29208769 |
| 2013 | HAVcR-1 expression in human colorectal cancer and its effects on colorectal cancer cells in vitro. | Anticancer research | 20 | 23267147 |
| 2011 | TIM-1 signaling in B cells regulates antibody production. | Biochemical and biophysical research communications | 20 | 21303660 |
| 2019 | Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury. | Cell communication and signaling : CCS | 19 | 31438964 |
| 2018 | Anti-TIM-1 Monoclonal Antibody (RMT1-10) Attenuates Atherosclerosis By Expanding IgM-producing B1a Cells. | Journal of the American Heart Association | 19 | 29936416 |
| 2016 | Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. | Journal of immunology (Baltimore, Md. : 1950) | 19 | 26792807 |
| 2011 | Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1). | Molecular immunology | 19 | 21513984 |
| 2008 | Correlation between humoral and cellular immune responses and the expression of the hepatitis A receptor HAVcr-1 on T cells after hepatitis A re-vaccination in high and low-responder vaccinees. | Vaccine | 18 | 18996424 |
| 2018 | MiR-15a/16-1 deficiency induces IL-10-producing CD19+ TIM-1+ cells in tumor microenvironment. | Journal of cellular and molecular medicine | 17 | 30467955 |
| 2011 | Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population. | Mutagenesis | 17 | 21367814 |
| 2009 | Association analysis of TIM-1 -232G > A and 5383_5397 insertion/deletion polymorphisms with childhood asthma and total serum immunoglobulin E levels in middle China. | Journal of investigational allergology & clinical immunology | 17 | 19476019 |
| 2018 | CD27+TIM-1+ memory B cells promoted the development of Foxp3+ Tregs and were associated with better survival in acute respiratory distress syndrome. | Immunologic research | 16 | 29392553 |
| 2018 | HAVCR1 (CD365) and Its Mouse Ortholog Are Functional Hepatitis A Virus (HAV) Cellular Receptors That Mediate HAV Infection. | Journal of virology | 16 | 29437974 |
| 2009 | Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios. | International archives of allergy and immunology | 16 | 19494522 |
| 2007 | The role of the T-cell costimulatory molecule Tim-1 in the immune response. | Immunologic research | 16 | 17917055 |
| 2006 | Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins. | International immunology | 16 | 16481347 |
| 2019 | HAVCR1 Affects the MEK/ERK Pathway in Gastric Adenocarcinomas and Influences Tumor Progression and Patient Outcome. | Gastroenterology research and practice | 15 | 31885544 |
| 2013 | Expression of Tim-1 and Tim-3 in Plasmodium berghei ANKA infection. | Parasitology research | 15 | 23653017 |
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