{"gene":"HAVCR1","run_date":"2026-06-14T07:33:11","timeline":{"discoveries":[],"current_model":"Parse failed"},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q96D42","full_name":"Hepatitis A virus cellular receptor 1","aliases":["Kidney injury molecule 1","KIM-1","T-cell immunoglobulin and mucin domain-containing protein 1","TIMD-1","T-cell immunoglobulin mucin receptor 1","TIM","TIM-1","T-cell membrane protein 1"],"length_aa":364,"mass_kda":39.2,"function":"Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (PubMed:18414680). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (PubMed:18414680) (Microbial infection) Acts as a receptor for Hepatitis A virus (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564) (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433) (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E (Microbial infection) Plays a positive role in Chikungunya virus cell entry","subcellular_location":"Cell membrane; Cell projection, phagocytic cup; Cytoplasmic vesicle, phagosome","url":"https://www.uniprot.org/uniprotkb/Q96D42/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/HAVCR1","classification":"Not Classified","n_dependent_lines":1,"n_total_lines":1208,"dependency_fraction":0.0008278145695364238},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/HAVCR1","total_profiled":1310},"omim":[{"mim_id":"611162","title":"MALARIA, SUSCEPTIBILITY TO","url":"https://www.omim.org/entry/611162"},{"mim_id":"610705","title":"CD300 ANTIGEN-LIKE FAMILY, MEMBER B; CD300LB","url":"https://www.omim.org/entry/610705"},{"mim_id":"610096","title":"T-CELL IMMUNOGLOBULIN AND MUCIN DOMAINS-CONTAINING PROTEIN 4; TIMD4","url":"https://www.omim.org/entry/610096"},{"mim_id":"606652","title":"HEPATITIS A VIRUS CELLULAR RECEPTOR 2; HAVCR2","url":"https://www.omim.org/entry/606652"},{"mim_id":"606518","title":"HEPATITIS A VIRUS CELLULAR RECEPTOR 1; HAVCR1","url":"https://www.omim.org/entry/606518"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Uncertain","locations":[{"location":"Vesicles","reliability":"Uncertain"}],"tissue_specificity":"Group enriched","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"intestine","ntpm":4.3},{"tissue":"kidney","ntpm":6.5}],"url":"https://www.proteinatlas.org/search/HAVCR1"},"hgnc":{"alias_symbol":["HAVCR-1","TIM-1","TIM1","HAVCR","TIMD1","CD365","KIM1"],"prev_symbol":[]},"alphafold":{"accession":"Q96D42","domains":[{"cath_id":"2.60.40.10","chopping":"20-126","consensus_level":"high","plddt":92.8892,"start":20,"end":126}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96D42","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96D42-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96D42-F1-predicted_aligned_error_v6.png","plddt_mean":65.81},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=HAVCR1","jax_strain_url":"https://www.jax.org/strain/search?query=HAVCR1"},"sequence":{"accession":"Q96D42","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96D42.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96D42/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96D42"}},"corpus_meta":[{"pmid":"18082433","id":"PMC_18082433","title":"TIM-1 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