Affinage

GSDMB

Gasdermin-B · UniProt Q8TAX9

Length
416 aa
Mass
47.3 kDa
Annotated
2026-06-10
58 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GSDMB is a pore-forming gasdermin that executes pyroptosis when its autoinhibited full-length form is cleaved by cytotoxic-lymphocyte granzyme A (GZMA), releasing an N-terminal fragment that assembles into a 27-fold-symmetric membrane pore (PMID:32299851, PMID:36991125). Cleavage requires GZMA to dimerize and engage an exosite on the autoinhibitory GSDMB C-terminal domain, positioning the protease for productive cut at Lys244 (PMID:41592574). Pore-forming competence is dictated by alternative splicing of exon 6, which supplies a belt motif essential for membrane insertion: exon-6-containing isoforms 3/4 are pyroptotic, whereas isoforms lacking intact exon 6 are inert and act as dominant-negative blockers of pyroptosis (PMID:36991125, PMID:37115914, PMID:36899106). GSDMB activity is further gated by proteases that produce inhibitory fragments—caspase-7 cleaves at D91 to generate a C-terminal fragment that rebinds and neutralizes the N-domain, while neutrophil elastase and caspases yield non-cytotoxic products (PMID:36899106, PMID:37591921). Beyond pore formation, the GSDMB N-domain (residues 1–91) binds the caspase-4 CARD to promote non-canonical pyroptosis through GSDMD cleavage (PMID:30321352, PMID:37591921), and GSDMB exerts direct bactericidal activity by recognizing phospholipids on Gram-negative bacterial membranes; the Shigella effector IpaH7.8 counters this by ubiquitinating the GSDMB pore-forming domain for proteasomal degradation (PMID:36991125, PMID:34022140, PMID:36599845). Independent of cell death, GSDMB promotes epithelial restitution via a PDGF-A/FAK/focal-adhesion axis (PMID:35021065), activates cGAS-STING signaling by binding the STING C-terminus to drive Golgi translocation and IRF3 phosphorylation (PMID:38737375), and in airway and cancer contexts couples to 5-LO/TGF-β1, STAT3, and IGF2BP1/DUSP6 to modulate remodeling and proliferation (PMID:27799535, PMID:34326684, PMID:39353395).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2020 High

    Established the central activating event by showing that cytotoxic-lymphocyte GZMA cleaves GSDMB to unleash pore-forming pyroptosis, placing GSDMB downstream of immune killing rather than as a passive marker.

    Evidence In vitro cleavage, NK/CTL co-culture killing assays, IFN-γ induction, and mouse tumor models

    PMID:32299851

    Open questions at the time
    • Did not resolve the structural basis of cleavage specificity
    • Isoform dependence of pyroptosis not yet defined
  2. 2008 Low

    Initial localization studies framed GSDMB as a cytoplasmic, sometimes nuclear, protein with secretory-pathway-associated vesicular staining and a proliferative effect, before any pore-forming function was known.

    Evidence Immunohistochemistry, GFP-fusion imaging, and proliferation assays in cancer cell lines

    PMID:18038310 PMID:18633457

    Open questions at the time
    • No functional consequence of localization established
    • Cell-type discrepancy in nuclear vs cytoplasmic localization unexplained
  3. 2010 Medium

    Identified a cis-regulatory mechanism by showing an upstream Alu element with an IKZF binding motif positively drives GSDMB expression, addressing how the gene is transcriptionally controlled.

    Evidence Reporter assays with intact, deleted, and mutated Alu constructs plus patient tissue expression

    PMID:20410667

    Open questions at the time
    • IKZF binding inferred from motif, not directly demonstrated
    • Regulation in non-cancer tissue not addressed
  4. 2016 Medium

    Linked GSDMB to airway disease by showing it drives TGF-β1 expression via 5-LO and causes airway hyperresponsiveness in transgenic mice, a death-independent role.

    Evidence Overexpression in bronchial epithelium, 5-LO siRNA epistasis, and a hGSDMB transgenic mouse

    PMID:27799535

    Open questions at the time
    • Mechanism linking GSDMB to 5-LO induction unknown
    • Relationship to pore-forming function not established
  5. 2019 Medium

    Revealed a non-pore-forming role in inflammasome signaling by showing the GSDMB N-domain binds the caspase-4 CARD to promote non-canonical pyroptosis and GSDMD cleavage.

    Evidence Co-IP of GSDMB-caspase-4 CARD, caspase activity assays, and GSDMD cleavage readouts

    PMID:30321352

    Open questions at the time
    • Single-lab Co-IP without structural validation
    • How GSDMB enhances caspase-4 activity mechanistically unresolved
  6. 2021 High

    Defined the host-pathogen conflict and a direct antibacterial function: Shigella IpaH7.8 ubiquitinates GSDMB for proteasomal destruction, while GSDMB itself kills Gram-negative bacteria by recognizing their membrane phospholipids.

    Evidence Reciprocal Co-IP, ubiquitination and proteasome-inhibitor assays, bacterial lipid-binding, and NK killing assays

    PMID:34022140

    Open questions at the time
    • Structural basis of IpaH7.8 recognition not yet determined here
    • Specificity of bacterial phospholipid recognition incompletely defined
  7. 2021 Medium

    Connected GSDMB to oncogenic signaling by identifying a USP24/GSDMB/STAT3 axis that stabilizes GSDMB and promotes bladder cancer growth.

    Evidence Co-IP/MS, STAT3 phosphorylation assays, USP24 inhibitor treatment, and xenografts

    PMID:34326684

    Open questions at the time
    • Direct vs indirect GSDMB-STAT3 interaction not resolved
    • How GSDMB modulates glucose metabolism mechanistically unknown
  8. 2022 High

    Established a pyroptosis-independent epithelial repair function, showing GSDMB drives wound closure via PDGF-A-mediated FAK phosphorylation and focal-adhesion turnover, with disease SNPs disrupting this.

    Evidence Knockout/knockdown in epithelial cells and organoids, wound-closure, focal-adhesion, and FAK phosphorylation assays

    PMID:35021065

    Open questions at the time
    • Molecular link between GSDMB and PDGF-A signaling undefined
    • Relation to the pore-forming domain not established
  9. 2023 High

    Provided the structural mechanism of pore formation and bacterial subversion: the cryo-EM 27-fold pore and IpaH7.8-GSDMB crystal structures, demonstrating that exon-6-derived belt elements are essential for membrane insertion.

    Evidence X-ray crystallography of full-length GSDMB and IpaH7.8 complex, cryo-EM of the pore, plus mutagenesis

    PMID:36599845 PMID:36991125

    Open questions at the time
    • Mechanism of pore nucleation kinetics not resolved
    • Lipid selectivity of human membrane pores incompletely defined
  10. 2023 High

    Resolved the functional logic of splicing and proteolysis: exon-6 isoforms (3/4) are cytotoxic while exon-6-deficient isoforms act as dominant-negative inhibitors, and elastase/caspase cleavage generates non-cytotoxic fragments that gate death.

    Evidence Isoform expression and GZMA/elastase/caspase cleavage assays, NK killing, dominant-negative experiments, and mitochondrial damage assays

    PMID:36899106 PMID:37115914

    Open questions at the time
    • Physiological balance of isoform expression in tissues not quantified
    • Mechanism of dominant-negative inhibition structurally undefined
  11. 2023 Medium

    Identified an apoptosis-coupled brake: caspase-7 cleaves GSDMB at D91, generating a C-terminal fragment that rebinds the N-domain to block non-canonical pyroptosis.

    Evidence Caspase-7 cleavage assays, Co-IP of the auto-inhibitory interaction, bacterial infection and septic mouse models

    PMID:37591921

    Open questions at the time
    • Single-lab interaction mapping without structure
    • Crosstalk timing between apoptosis and pyroptosis unresolved
  12. 2024 Medium

    Expanded GSDMB into innate antiviral signaling by showing it binds the STING C-terminus to drive Golgi translocation and IRF3 phosphorylation, and identified pharmacological control of its activation via 4-OI modifying GZMA.

    Evidence Co-IP, STING translocation imaging, IRF3 phosphorylation readouts, and MS-based identification of 4-OI sites on GZMA

    PMID:38737375 PMID:38982510

    Open questions at the time
    • GSDMB-STING interaction shown in single lung-cell context
    • Whether STING role depends on pore formation unknown
  13. 2024 Medium

    Linked GSDMB to anti-proliferative signaling in colorectal cancer through an IGF2BP1/DUSP6/ERK axis, contrasting with its pro-proliferative role in other cancers.

    Evidence Co-IP of GSDMB-IGF2BP1, IGF2BP1-DUSP6 3'-UTR binding, ERK phosphorylation assays, and transgenic/organoid models

    PMID:39353395

    Open questions at the time
    • Tissue-context basis for opposing cancer roles unexplained
    • Direct vs indirect GSDMB effect on IGF2BP1 activity unclear
  14. 2025 Medium

    Added transcriptional control and an EMT phenotype, showing GATA1 binds the GSDMB promoter and GSDMB overexpression promotes EMT, proliferation, and migration in TGF-β1-treated bronchial cells.

    Evidence ChIP for GATA1 binding, gain-of-function with EMT marker, proliferation and migration assays

    PMID:41092691

    Open questions at the time
    • Relationship of EMT role to pore-forming activity undefined
    • Single cell-line context
  15. 2026 High

    Defined the molecular basis of GZMA selectivity for GSDMB: a dimerization-dependent exosite engages the autoinhibitory GSDMB-C domain in 2:2 stoichiometry to enable cleavage at Lys244, explaining why mouse GZMA fails to activate GSDMB.

    Evidence Crystal structure of the GZMA-GSDMB-C complex, binding affinity and dimerization analysis, and exosite mutagenesis with cleavage assays

    PMID:41592574

    Open questions at the time
    • How exosite engagement is regulated in cells unknown
    • Whether other granzymes use analogous exosites untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how GSDMB's pyroptotic, antibacterial, epithelial-repair, STING-signaling, and proliferative functions are coordinated within a single cell, and which domains/isoforms partition between these roles.
  • No unified model linking pore-forming and signaling functions
  • Tissue-specific isoform expression maps lacking
  • In vivo relevance of non-pyroptotic axes incompletely established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0008289 lipid binding 2 GO:0060089 molecular transducer activity 2 GO:0090729 toxin activity 1
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1643685 Disease 2
Partners
CASP4CASP7GZMAIGF2BP1IPAH7.8STAT3STING1USP24

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 Granzyme A (GZMA) from cytotoxic lymphocytes directly cleaves GSDMB, unleashing its pore-forming activity and triggering pyroptosis in target cells. NK cells and cytotoxic T lymphocytes kill GSDMB-positive cells through this mechanism. IFN-γ upregulates GSDMB expression and promotes pyroptosis. Introducing GZMA-cleavable GSDMB into mouse cancer cells promotes tumor clearance in vivo. In vitro cleavage assays, cell death assays, NK/CTL co-culture killing assays, mouse tumor models, IFN-γ treatment experiments Science High 32299851
2023 Crystal structure of IpaH7.8-GSDMB complex reveals how the Shigella flexneri ubiquitin-ligase effector IpaH7.8 recognizes the GSDMB pore-forming domain and ubiquitinates it for proteasomal degradation. Full-length GSDMB crystal structure shows stronger autoinhibition than other gasdermins. Presence of exon 6 in GSDMB isoforms dictates pore-forming/pyroptotic activity. Cryo-EM structure of the 27-fold-symmetric GSDMB pore reveals conformational changes driving pore formation and an essential role for exon-6-derived elements in pore assembly. X-ray crystallography (IpaH7.8-GSDMB complex and full-length GSDMB), cryo-EM (GSDMB pore), biochemical ubiquitination assays, isoform pyroptosis assays, mutagenesis Nature High 36991125
2021 The Shigella flexneri effector IpaH7.8 ubiquitinates GSDMB and targets it for 26S proteasome-dependent destruction, protecting Shigella from NK cell bactericidal killing. GSDMB exhibits direct microbiocidal activity through recognition of phospholipids found on Gram-negative bacterial membranes, killing bacteria directly rather than by lysing host cells. Co-immunoprecipitation, ubiquitination assays, proteasome inhibitor experiments, NK cell killing assays, bacterial membrane lipid-binding assays, GSDMB knockdown/overexpression Cell High 34022140
2022 GSDMB promotes epithelial restitution and repair independent of pyroptosis in inflamed colonocytes. GSDMB-deficient epithelial cells show hyper-adhesiveness, enhanced formation of vinculin-based focal adhesions, and arrest in wound closure. This is dependent on PDGF-A-mediated FAK phosphorylation. Disease-associated GSDMB SNPs disrupt epithelial restitution/repair. GSDMB knockout/knockdown in epithelial cells and organoids, in vitro wound closure assays, transcriptome profiling, focal adhesion analysis, FAK phosphorylation assays, single-cell analysis Cell High 35021065
2019 GSDMB directly binds the CARD domain of caspase-4, promoting caspase-4 activity, which is required for cleavage of GSDMD in non-canonical pyroptosis. Downregulation of GSDMB alleviates GSDMD cleavage and cell death; overexpression promotes GSDMD cleavage and LDH release. Co-immunoprecipitation (GSDMB-caspase-4 CARD domain binding), caspase activity assays, GSDMB knockdown/overexpression, LDH release assays, Western blot for GSDMD cleavage Journal of molecular cell biology Medium 30321352
2016 GSDMB overexpression in primary human bronchial epithelium increases expression of TGF-β1 and 5-lipoxygenase (5-LO). GSDMB induces TGF-β1 expression via induction of 5-LO, as knockdown of 5-LO in GSDMB-overexpressing cells inhibited TGF-β1 expression. Transgenic mice expressing human GSDMB show spontaneous airway hyperresponsiveness and remodeling without inflammation. Overexpression in primary human bronchial epithelium, siRNA knockdown of 5-LO, transgenic mouse model (hGSDMBZp3-Cre), gene expression assays PNAS Medium 27799535
2023 GSDMB splicing isoforms are functionally distinct: isoforms 3 and 4 (containing exon 6) cause pyroptosis after GZMA cleavage, while isoforms 1, 2, and 5 (lacking intact exon 6) do not. Non-cytotoxic GSDMB N-terminal fragments block pyroptosis caused by cytotoxic isoforms in a dominant-negative manner. Upon NK cell attack, different isoforms lead to distinct cell death modes (pyroptosis, mixed pyroptosis/apoptosis, or apoptosis only). Isoform expression and GZMA cleavage assays, NK cell killing assays, cell death phenotype analysis (pyroptosis vs apoptosis markers), dominant-negative experiments, structural analysis of belt motif Science immunology High 37115914
2023 Exon 6 translation is essential for GSDMB-mediated pyroptosis; GSDMB isoforms lacking exon 6 (GSDMB1-2) cannot cause cancer cell death. GSDMB N-terminal constructs containing exon 6 provoke cell membrane lysis and concomitant mitochondrial damage. Specific residues within exon 6 and other N-terminal domain regions are important for GSDMB-triggered cell death and mitochondrial impairment. Neutrophil elastase and caspase cleavage of GSDMB produces short N-terminal fragments with no cytotoxic activity, suggesting these proteases act as inhibitory mechanisms of pyroptosis. Isoform expression and cell death assays, mutagenesis of specific residues, mitochondrial damage assays, protease cleavage assays (GZMA, neutrophil elastase, caspases), cell membrane lysis assays Cell death and differentiation High 36899106
2023 Crystal structure of GSDMB in complex with IpaH7.8 identifies membrane engagement sites of GSDMB. Structural analysis reveals how IpaH7.8 interacts with GSDMB and ubiquitinates it. Two residues in the α1-α2 loop of mouse GSDMD make it invulnerable to IpaH7.8-mediated degradation (non-identical to human). X-ray crystallography (GSDMB-IpaH7.8 complex), biochemical ubiquitination assays, mutagenesis of α1-α2 loop residues, functional degradation assays Nature communications High 36599845
2023 Caspase-7 cleaves GSDMB at the D91 site during apoptosis, generating a C-terminal fragment (92–417 aa) that binds back to the GSDMB N-terminus (1–91 aa) to block GSDMB's pro-pyroptotic function, thereby inhibiting non-canonical pyroptosis. The GSDMB N-domain (1–91 aa) is important for binding caspase-4 and promoting non-canonical pyroptosis. During bacterial infection (E. coli, S. Typhimurium) and in a septic mouse model, inhibition of caspase-7/GSDMB axis increased pyroptotic cell death. Caspase-7 cleavage assays, co-immunoprecipitation (GSDMB-C binding GSDMB-N, GSDMB binding caspase-4), cell death assays with bacterial infection models, caspase-7 inhibitor and knockout mouse experiments Cell death and differentiation Medium 37591921
2021 GSDMB interacts with STAT3 to increase STAT3 phosphorylation and modulate glucose metabolism in bladder cancer cells. USP24 (a deubiquitinase) stabilizes GSDMB by preventing its degradation, activating downstream STAT3 signaling. This USP24/GSDMB/STAT3 axis promotes bladder cancer growth. Mass spectrometry and co-immunoprecipitation (GSDMB-STAT3 and GSDMB-USP24 interactions), GSDMB overexpression/knockdown, STAT3 phosphorylation assays, USP24 inhibitor treatment, xenograft tumor models International journal of biological sciences Medium 34326684
2024 GSDMB interacts with the C-terminus of STING and promotes translocation of STING to the Golgi, leading to phosphorylation of IRF3 and induction of interferons and interferon-stimulated genes (ISGs) via the cGAS-STING pathway in bronchial epithelial cells. Co-immunoprecipitation (GSDMB-STING interaction), immunofluorescence (STING Golgi translocation), IRF3 phosphorylation assays, GSDMB overexpression and knockout in BEAS-2B and primary bronchial epithelial cells, qPCR/ELISA for IFN/ISG expression Journal of respiratory biology and translational medicine Medium 38737375
2024 4-Octyl itaconate (4-OI) inhibits GSDMB-mediated pyroptosis by directly modifying Cys54, Cys148, and Ser212 on granzyme A (GZMA), thereby blocking GZMA-mediated cleavage of GSDMB rather than acting on GSDMB itself. Mass spectrometry-based identification of 4-OI modification sites on GZMA, GZMA cleavage assays, pyroptosis assays, transgenic mouse colitis model Cell proliferation Medium 38982510
2024 GSDMB interacts with insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), which binds to and recognizes the 3'-UTR of DUSP6 mRNA, enhancing DUSP6 protein translation and inhibiting downstream ERK phosphorylation, thereby suppressing colorectal cancer cell proliferation. Co-immunoprecipitation (GSDMB-IGF2BP1), RNA-binding assays (IGF2BP1-DUSP6 3'-UTR), ERK phosphorylation assays, GSDMB transgenic mouse model, organoid experiments International immunopharmacology Medium 39353395
2026 Human GZMA targets GSDMB via specific, high-affinity binding to the autoinhibitory GSDMB-C domain. GZMA dimerization is required for this interaction. A crystal structure of the GZMA-GSDMB-C complex shows 2:2 stoichiometry with an exosite at each of two symmetric dimer interfaces in GZMA; the exosite engages a two-loop-organized site in the GSDMB-C domain, enabling functional cleavage at Lys244. Mouse GZMA has a less efficient exosite; mutation of the mouse GZMA exosite enabled it to efficiently cleave and activate GSDMB. X-ray crystallography (GZMA-GSDMB-C complex), binding affinity measurements, GZMA dimerization analysis, mutagenesis of exosite residues, cleavage assays with mouse/human GZMA variants Immunity High 41592574
2010 An Alu element in the 5' regulatory region upstream of GSDMB positively regulates GSDMB expression. A putative IKZF binding motif within this Alu element is crucial for upregulating GSDMB expression, as shown by reporter assays with intact, deleted, and mutated Alu elements. Reporter assays with intact, deleted, and mutated Alu element constructs; expression analysis in gastric cancer patient tissues Genes & genetic systems Medium 20410667
2008 GSDMB (GSDML) protein is localized to the cytoplasm in most cell types, but shows a distinctive vesicular staining pattern in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells, suggesting involvement in a secretory pathway. Immunohistochemistry and immunoblotting using anti-peptide antibodies developed against GSDML; in vitro transcription-translation for antibody specificity verification Pathology Low 18038310
2008 GFP-GSDMB (GSDML1) fusion protein localizes predominantly to the nucleus in MCF7 and HeLa cells but exclusively to the cytoplasm in HepG2 cells, indicating cell-type-dependent subcellular localization. Ectopic expression of GSDMB1 enhanced cell growth, while inhibition of its endogenous expression decreased proliferation. GFP fusion protein live cell imaging, siRNA knockdown and overexpression, BrdU incorporation assay, MTT-equivalent proliferation assays Translational oncology Low 18633457
2025 GATA1 binds to the promoter region of GSDMB and facilitates its expression. GSDMB overexpression upregulates mesenchymal markers and promotes epithelial-mesenchymal transition (EMT), as well as proliferation and migration in TGF-β1-treated bronchial epithelial cells. Chromatin immunoprecipitation (GATA1 binding to GSDMB promoter), GSDMB overexpression in Beas-2B cells with TGF-β1 treatment, EMT marker assays, proliferation and migration assays Molecular immunology Medium 41092691

Source papers

Stage 0 corpus · 58 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science (New York, N.Y.) 1064 32299851
2009 Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. American journal of human genetics 245 19732864
2022 GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. Cell 172 35021065
2016 GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation. Proceedings of the National Academy of Sciences of the United States of America 170 27799535
2021 Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions. Cell 166 34022140
2019 GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. Journal of molecular cell biology 145 30321352
2023 Structural mechanisms for regulation of GSDMB pore-forming activity. Nature 117 36991125
2008 Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 104 19133921
2021 USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway. International journal of biological sciences 101 34326684
2017 Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases. Advances in immunology 98 28826527
2017 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis. International journal of molecular sciences 88 28272342
2020 Role of GSDMB in Pyroptosis and Cancer. Cancer management and research 86 32431546
2020 Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. The Journal of allergy and clinical immunology 85 32795586
2004 Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. International journal of oncology 83 15010812
2008 Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues. Pathology 80 18038310
2023 Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science immunology 79 37115914
2010 Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB). Genes & genetic systems 73 20410667
2008 Expression of GSDML Associates with Tumor Progression in Uterine Cervix Cancer. Translational oncology 71 18633457
2023 Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Cell death and differentiation 68 36899106
2014 Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. Human molecular genetics 67 25256354
2006 Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells. Archives of virology 52 16625320
2014 The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis. Allergy, asthma & immunology research 46 25729625
2012 GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness. Human immunology 44 22732088
2023 Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage. Cell death and differentiation 36 37591921
2023 Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8. Nature communications 31 36599845
2013 The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC genomics 31 24044605
2017 Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis. Scientific reports 29 28588209
2008 Transcriptional regulation of GSDML gene by antisense-oriented HERV-H LTR element. Archives of virology 26 18478180
2015 A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells. BMC cancer 24 26016667
2020 ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization. Allergology international : official journal of the Japanese Society of Allergology 18 32444308
2024 The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs Expression. Journal of respiratory biology and translational medicine 14 38737375
2024 4-Octyl itaconate blocks GSDMB-mediated pyroptosis and restricts inflammation by inactivating granzyme A. Cell proliferation 10 38982510
2023 The study of GSDMB in pathogenesis of psoriasis vulgaris. PloS one 9 36607980
2023 Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer. The FEBS journal 9 37997534
2023 From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMB. Chinese medical journal pulmonary and critical care medicine 8 39171126
2022 Association Between GSDMB Gene Polymorphism and Cervical Cancer in the Northeast Chinese Han Population. Frontiers in genetics 8 35832190
2021 Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases. Biochemical genetics 8 33963941
2021 The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort. International forum of allergy & rhinology 8 34076350
2023 Association between polymorphisms of the GSDMB gene and allergic rhinitis risk in the Chinese population: a case-control study. The Journal of asthma : official journal of the Association for the Care of Asthma 7 36847643
2023 Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population. Frontiers in genetics 7 37359371
2022 CYSLTR1 rs320995 (T927C) and GSDMB rs7216389 (G1199A) Gene Polymorphisms in Asthma and Allergic Rhinitis: A Proof-of-Concept Study. Journal of asthma and allergy 7 36034974
2024 GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway. International immunopharmacology 5 39353395
2024 Gasdermin B (GSDMB) in psoriatic patients-a preliminary comprehensive study on human serum, urine and skin. Frontiers in molecular biosciences 4 38693919
2023 Anlotinib Enhances the Therapeutic Effect of Bladder Cancer with GSDMB Expression: Analyzed from TCGA Bladder Cancer Database & Mouse Bladder Cancer Cell Line. Pharmacogenomics and personalized medicine 3 36960215
2023 Association of childhood asthma with Gasdermin B (GSDMB) and Oromucoid-like 3 (ORMDL3) genes. Northern clinics of Istanbul 3 38328715
2026 Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing. Immunity 1 41592574
2025 Association of rs7216389 Polymorphism in Gasdermin B (GSDMB) With Childhood Asthma: A Case-Control Study. Cureus 1 39906448
2024 GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. Archives of biochemistry and biophysics 1 39029644
2023 Structural and functional insights into GSDMB isoforms complex roles in pathogenesis. Cell cycle (Georgetown, Tex.) 1 38037340
2026 Preliminary Study on GZMA- and GSDMB-Associated Pyroptosis and CD8+ T Cell-Mediated Immune Evasion in Skin Cutaneous Melanoma. Current topics in medicinal chemistry 0 40755114
2026 Correction: Gasdermin B (GSDMB) in psoriatic patients-a preliminary comprehensive study on human serum, urine and skin. Frontiers in molecular biosciences 0 41777669
2026 Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients. Diabetes/metabolism research and reviews 0 41782559
2026 Upper Airway Microbiome Interacts with GSDMB and ORMDL3 Asthma Risk SNPs to Influence Early-Life Wheeze Risk. The Journal of allergy and clinical immunology 0 42248217
2025 Unveiling genetic links: GSDMB polymorphisms and asthma susceptibility in the Zhuang Nationality of Guangxi. Respiratory medicine 0 40480530
2025 ZnO@Cu5.4O Nanoparticle Alleviates Inflammatory Responses of Intestinal Epithelial Cells by Inhibiting the Expression of GSDMB. ACS omega 0 40521506
2025 0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor. Cancer cell international 0 40581678
2025 GATA1 promotes TGF-β1-induced epithelial-mesenchymal transition by regulating GSDMB in human bronchial epithelial cells. Molecular immunology 0 41092691
2023 Corrigendum: Association between GSDMB gene polymorphism and cervical cancer in the Northeast Chinese Han population. Frontiers in genetics 0 38028599

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