Affinage

GOPC

Golgi-associated PDZ and coiled-coil motif-containing protein · UniProt Q9HD26

Length
462 aa
Mass
50.5 kDa
Annotated
2026-06-10
42 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GOPC (PIST/FIG) is a trans-Golgi network-resident scaffolding protein that governs the sorting and surface delivery of diverse transmembrane cargo, acting through a modular architecture of PDZ, coiled-coil, and leucine zipper domains (PMID:16882988, PMID:11162552). Its canonical mode of action is to engage the C-terminal class I PDZ-binding motifs of cargo proteins and thereby retain them in the TGN, modulating whether they reach the plasma membrane; this PDZ-dependent retention has been demonstrated for GPCRs including SSTR5 and β1-adrenergic receptor (PMID:16012170, PMID:25614626), the transmembrane mucin MUC3 (PMID:21852426), the sodium-phosphate transporter NaPi-2a (PMID:23509734), the cadherin-family adhesion proteins CDH23 and PCDH15 (PMID:20958966), and the proteoglycan syndecan-1 (PMID:35830596). Cargo release from GOPC is controlled by competition from other PDZ proteins (e.g. PSD-95, MAGI-1/harmonin) and by signaling inputs that relocalize GOPC from the TGN to endosomes, where it can protect internalized receptors from lysosomal degradation (PMID:25614626, PMID:20958966). Beyond retention, GOPC is required for productive anterograde trafficking of several cargoes, partnering with the GTPase ARFRP1 to deliver SNAP25 and support glucose-stimulated insulin secretion (PMID:33359402), directing tight-junction component traffic from the TGN in polarized epithelia (PMID:25616555), and targeting mGluR5 and neuroligin-1 to neuronal synapses where it influences synaptic plasticity and contextual learning (PMID:34383253). At the organismal level GOPC is essential for acrosomal vesicle fusion during spermiogenesis, and its loss causes globozoospermia and male infertility in mice (PMID:12149515). GOPC abundance is set by ubiquitin-dependent proteasomal degradation: the deubiquitinase UCHL3 stabilizes GOPC and protects acrosome biogenesis (PMID:40784473), whereas the HSV-1 protein pUL56 binds GOPC and drives its ubiquitination and degradation to remodel the infected-cell surface proteome (PMID:33027661). GOPC also serves as the N-terminal partner in oncogenic GOPC-ROS1 fusions, contributing a coiled-coil dimerization module that activates the ROS1 kinase domain (PMID:40819798, PMID:23545662).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2001 Medium

    Established the biochemical basis for GOPC's scaffolding behavior by defining its domain-dependent self-association and partner binding, distinguishing the leucine zipper (dimerization, GTPase binding) from the PDZ domain (cargo binding).

    Evidence Yeast two-hybrid, in vitro binding and deletion mutagenesis mapping TC10:GTP binding and homodimerization; reciprocal co-IP and brefeldin A showing PDZ-dependent frizzled binding and Golgi-to-PM transport

    PMID:11162552 PMID:11520064

    Open questions at the time
    • Physiological consequence of TC10 binding not established
    • Generality of PDZ-motif cargo recognition not yet shown beyond frizzled at this stage
  2. 2002 High

    Resolved GOPC's in vivo requirement by showing it is essential for acrosomal vesicle fusion, linking a Golgi scaffold to a defined developmental membrane-fusion event.

    Evidence GOPC-deficient knockout mouse with electron microscopy and immunofluorescence demonstrating acrosome fragmentation and globozoospermia; fertility rescued by ICSI

    PMID:12149515

    Open questions at the time
    • Molecular fusion machinery downstream of GOPC at the acrosome not identified
    • Whether the spermiogenesis role uses the same PDZ-cargo mechanism as somatic trafficking unknown
  3. 2005 High

    Generalized the cargo-retention model by showing GOPC retains GPCRs in the Golgi via PDZ-motif binding and controls their postendocytic recycling, and mapped a coiled-coil interaction with the Golgi structural protein golgin-160.

    Evidence Yeast two-hybrid, cell-surface recycling assays for SSTR5; GST pulldown, co-IP and isoform analysis for golgin-160 binding

    PMID:15951434 PMID:16012170

    Open questions at the time
    • How the golgin-160 interaction couples to cargo sorting not defined
    • Recycling mechanism for SSTR5 vs other cargo not compared
  4. 2006 High

    Provided the structural definition of the GOPC PDZ domain as a canonical class I module and characterized its low-affinity recognition of C-terminal motifs, while adding Rho-regulated recruitment of Rhotekin to junctions.

    Evidence NMR solution structure with chemical shift perturbation against neuroligin peptide and MD modeling; co-IP, in vitro binding and dominant-active Rho perturbation for Rhotekin

    PMID:16646955 PMID:16882988

    Open questions at the time
    • Affinity is low, leaving avidity/clustering contributions unresolved
    • Whether Rho signaling regulates other GOPC-cargo interactions not tested
  5. 2013 Medium

    Extended the retention/competition paradigm across structurally diverse cargo classes (ion channels, transporters) and revealed isoform-specific outputs, showing GOPC can either enhance or restrain surface expression depending on cargo and isoform.

    Evidence Co-IP, surface expression and transport assays plus isoform/domain dissection for KV10.1 and NaPi-2a; preliminary crystallization of the coiled-coil (29-133)

    PMID:23509734 PMID:23545662 PMID:23966943

    Open questions at the time
    • Coiled-coil structure only at 4.0 Å, not solved
    • Mechanistic basis for divergent isoform effects on the same cargo unresolved
  6. 2016 Medium

    Consolidated GOPC as a general regulator of plasma-membrane and junctional cargo by demonstrating cargo retention controlled by competitive PDZ displacement and a role in tight-junction component trafficking.

    Evidence Co-IP and TGN-retention assays with competitive coexpression (MAGI-1/harmonin) for CDH23/PCDH15; siRNA knockdown with transepithelial resistance, paracellular flux and claudin assays for tight junctions

    PMID:20958966 PMID:25616555 PMID:27867666

    Open questions at the time
    • PCDH15 evidence rests on a single co-IP/colocalization study
    • Direct cargo for claudin trafficking not mapped
  7. 2021 High

    Linked GOPC trafficking activity to physiology in neurons and secretory cells, establishing roles in synaptic receptor targeting, plasticity/behavior, and ARFRP1-dependent SNAP25 delivery for insulin secretion.

    Evidence Conditional KO and shRNA in neurons with synaptic fractionation, LTD and fear conditioning for mGluR5/Nlgn1; pulldown-MS, co-IP, KO mouse and glucose-stimulated insulin secretion rescue for ARFRP1/SNAP25; β1AR trafficking with KO mouse brain analysis

    PMID:25614626 PMID:33359402 PMID:34383253

    Open questions at the time
    • How signaling (cAMP) triggers GOPC relocalization to endosomes mechanistically unclear
    • Whether SNAP25 delivery uses PDZ binding or coiled-coil/ARFRP1 route not dissected
  8. 2020 High

    Defined how GOPC levels are post-translationally controlled, showing that ubiquitin-dependent degradation gates its scaffolding function and that pathogens exploit this to remodel the cell surface.

    Evidence Co-IP, ubiquitination and proteasome-inhibitor assays plus plasma-membrane proteomics for HSV-1 pUL56-driven GOPC degradation; MC-LR-induced GOPC ubiquitination via dual inhibition of UCHL3 with binding, ubiquitination and stability assays

    PMID:33027661 PMID:40784473

    Open questions at the time
    • The endogenous E3 ligase for GOPC not identified
    • MC-LR/UCHL3 axis evidence from a single study
  9. 2025 Medium

    Characterized two additional disease-relevant contexts: GOPC as a host factor recruited to Leishmania parasitophorous vacuoles through a Beclin1/Golgin160 axis, and GOPC as the dimerization-providing fusion partner that activates ROS1 kinase signaling.

    Evidence Co-IP, colocalization, GP63-KO parasites and caspase inhibition for the Leishmania/Beclin1 axis; phosphoproteomics, fusion overexpression and ZO-1 phosphosite analysis for GOPC-ROS1; AP-MS identifying SHP2 (preprint)

    PMID:38556987 PMID:40819798 PMID:41269215 PMID:bio_10.1101_2025.05.27.656302

    Open questions at the time
    • Direct autophagy mechanism (Beclin1-PI3KC3) downstream of GOPC at PVs not fully resolved
    • SHP2 interaction with GOPC-ROS1 unvalidated functionally (preprint)

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how GOPC mechanistically switches between cargo retention and productive anterograde/recycling delivery, and what upstream signals and modifications dictate this choice for a given cargo.
  • No unified model connecting domain occupancy, competitive displacement, and signaling-driven relocalization
  • Endogenous E3 ligase and full ubiquitination code for GOPC undefined
  • Acrosome fusion machinery downstream of GOPC unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005794 Golgi apparatus 5 GO:0005886 plasma membrane 2 GO:0005768 endosome 1
Pathway
R-HSA-9609507 Protein localization 5 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-1643685 Disease 3
Partners
ARFRP1BECN1CDH23GOLGA3ROS1RTKNSNAP25UCHL3

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 GOPC is predominantly localized at the trans-Golgi region in round spermatids; GOPC-deficient male mice are infertile with globozoospermia due to fragmentation of acrosomes in early round spermatids — abnormal vesicles fail to fuse to developing acrosomes — establishing GOPC as essential for acrosomal vesicle fusion during spermiogenesis. Gene knockout mouse (GOPC-deficient), electron microscopy, immunofluorescence, intracytoplasmic sperm injection (ICSI) Proceedings of the National Academy of Sciences of the United States of America High 12149515
2001 GOPC (PIST) directly and specifically binds TC10:GTP (a Rho-family GTPase) via a leucine zipper-containing coiled-coil domain; the first coiled-coil and PDZ domains are not required for TC10 binding, but deletion of the N-terminal portion of the leucine zipper abolishes dimerization. GOPC also forms homodimers. Yeast two-hybrid, in vitro binding assays, deletion mutagenesis Biochemical and biophysical research communications Medium 11162552
2001 GOPC interacts with frizzled via the PDZ domain of GOPC and the C-terminal Ser/Thr-X-Val motif of frizzled, both in vivo and in vitro; GOPC and frizzled colocalize at the Golgi apparatus, and coexpression of GOPC with frizzled causes translocation of GOPC to the plasma membrane. Brefeldin A disrupts both GOPC Golgi localization and frizzled plasma membrane targeting, indicating GOPC participates in vesicle transport of frizzled from Golgi to plasma membrane. Co-immunoprecipitation, in vitro binding, immunofluorescence, deletion mutagenesis, brefeldin A treatment Biochemical and biophysical research communications Medium 11520064
2005 GOPC (PIST) interacts with somatostatin receptor subtype 5 (SSTR5) via the PDZ ligand motif at the receptor's C-terminus and retains SSTR5 in the Golgi apparatus when coexpressed. Endogenous SSTR5 in AtT-20 cells colocalizes with PIST in the Golgi. Removal of the PDZ ligand motif inhibits receptor recycling to the plasma membrane after agonist washout, indicating PIST/GOPC is required for postendocytic sorting of SSTR5. Yeast two-hybrid, coexpression/immunofluorescence, deletion mutagenesis, cell-surface recycling assay The Journal of biological chemistry Medium 16012170
2005 GOPC (PIST) interacts with golgin-160 via an internal coiled-coil region of PIST and a leucine-rich repeat within golgin-160; they colocalize to Golgi membranes and interact in vivo. A widely expressed isoform, golgin-160B, lacks the leucine repeat and cannot bind PIST. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, immunofluorescence colocalization, isoform cloning The Journal of biological chemistry High 15951434
2006 GOPC (PIST) PDZ domain solution structure was solved by NMR; it is a canonical class I PDZ domain with two alpha-helices and six beta-strands. Chemical shift perturbation experiments showed the GOPC PDZ domain binds the C-terminal motif of neuroligin in fast exchange with low affinity, and a 3D complex model was constructed by molecular dynamics simulation. NMR structure determination, chemical shift perturbation, molecular dynamics simulation Protein science : a publication of the Protein Society High 16882988
2006 GOPC (PIST) binds Rhotekin via its PDZ domain interacting with the C-terminal SPV motif of Rhotekin; this interaction occurs in vitro and in MDCK cells. Activated Rho markedly inhibits the Rhotekin-PIST interaction. PIST and Rhotekin colocalize at the Golgi in non-polarized cells and at adherens junctions in polarized cells, and PIST is involved in recruiting Rhotekin to adherens junctions. Yeast two-hybrid, in vitro binding, co-immunoprecipitation, immunofluorescence, dominant-active Rho expression The Biochemical journal Medium 16646955
2010 GOPC (PIST) binds cadherin 23 (CDH23) via the PIST PDZ domain and the C-terminal PDZ domain-binding interface of CDH23, retaining CDH23 in the trans-Golgi network. Co-expression of MAGI-1 or harmonin releases CDH23 from PIST retention, suggesting competitive displacement. Co-immunoprecipitation, immunofluorescence colocalization, TGN retention assay, competitive coexpression BMC cell biology Medium 20958966
2011 GOPC PDZ domain binds the C-terminal PDZ motif of transmembrane mucin MUC3. GOPC overexpression downregulates total MUC3 levels, and this effect is reversed by co-introduction of CFTR, indicating CFTR and MUC3 compete for GOPC binding. GOPC also directs CFTR for degradation. PDZ domain binding screen (123 PDZ domains), co-immunoprecipitation, overexpression with protein level assays Journal of cell science Medium 21852426
2013 GOPC (PIST) mediates a PDZ domain-dependent interaction with the voltage-gated potassium channel KV10.1, enhancing KV10.1 surface levels. The functional (but not physical) interaction requires both coiled-coil and PDZ domains of PIST. The neural isoform nPIST interacts physically but does not alter KV10.1 surface expression. A short isoform sPIST lacks PDZ domain, does not co-precipitate with KV10.1, but reduces KV10.1 surface expression in a dominant-negative manner. Co-immunoprecipitation from native and expression systems, surface expression assay, isoform cloning and expression, domain mutagenesis Frontiers in physiology Medium 23966943
2013 GOPC (PIST) interacts with NaPi-2a (sodium-phosphate transporter) in the trans-Golgi network during retrograde trafficking from the plasma membrane. PIST overexpression retains NaPi-2a in the TGN and inhibits Na-dependent phosphate transport in OK cells, and prevents adaptation to low-phosphate medium. Co-immunoprecipitation, immunofluorescence, phosphate transport functional assay, overexpression in OK cells BioMed research international Medium 23509734
2015 GOPC (PIST) controls β1-adrenergic receptor (β1AR) trafficking in both anterograde (biosynthetic) and postendocytic pathways. PIST overexpression retains β1AR in the trans-Golgi network and reduces MAPK signaling by agonist; coexpression with PSD-95 releases receptors to the plasma membrane. cAMP pathway activation relocalizes PIST from TGN to SNX1-positive endosomes where it colocalizes with internalized β1AR and protects receptors from lysosomal degradation. β1AR levels are decreased in hippocampi of PIST-deficient mice. Overexpression/knockdown, immunofluorescence colocalization, MAPK signaling assay, PIST-KO mouse brain analysis The Journal of biological chemistry High 25614626
2015 GOPC localizes to the trans-Golgi network (TGN) in MDCK cells, colocalizing with Rab5 and Rab14 but not Rab11. Knockdown of GOPC decreases transepithelial resistance, increases paracellular flux, and reduces lateral claudin-1 labeling and claudin-2 protein levels, indicating GOPC is required for trafficking of tight junction components from the TGN. Immunofluorescence colocalization, siRNA knockdown, transepithelial resistance measurement, paracellular flux assay, western blot Cell and tissue research Medium 25616555
2016 GOPC (PIST) interacts with protocadherin 15 (PCDH15) via the PDZ domain of PIST and the C-terminal PDZ domain-binding interface of PCDH15, retaining PCDH15 in the trans-Golgi network and reducing its membrane expression. Co-immunoprecipitation, immunofluorescence, TGN retention assay Neural plasticity Low 27867666
2020 HSV-1 protein pUL56 directly binds GOPC, stimulates its ubiquitination and proteasomal degradation. pUL56-mediated GOPC degradation alters cell-surface proteome of infected cells, including loss of TLR2 surface expression, which is GOPC-dependent. Quantitative multiplexed proteomics (TMT), plasma membrane profiling, co-immunoprecipitation, ubiquitination assay, proteasome inhibitor experiments Cell reports High 33027661
2020 GOPC interacts with the GTPase ARFRP1 at the trans-Golgi network and together they regulate plasma membrane localization of the SNARE protein SNAP25; knockdown of both GOPC and ARFRP1 in Min6 cells reduces SNAP25 plasma membrane localization and enhances its degradation, impairing glucose-stimulated insulin secretion. Overexpression of SNAP25 or GOPC restores insulin secretion in β-cell-specific Arfrp1-KO islets. Pulldown with mass spectrometry, co-immunoprecipitation, super-resolution microscopy, siRNA knockdown, glucose-stimulated insulin secretion assay, KO mouse Molecular metabolism High 33359402
2021 GOPC (Gopc) is required for synaptic targeting of mGluR5 and neuroligin 1 (Nlgn1) in neurons; knockdown in primary cultured neurons and conditional KO mouse both show impaired plasma membrane targeting of mGlu5 and Nlgn1, while NMDA receptors were unaffected. In Gopc KO hippocampus/cortex, mGlu5 targeting to postsynaptic density is reduced, coinciding with alterations in mGluR-dependent synaptic plasticity and deficits in contextual fear conditioning. shRNA knockdown in primary neurons, conditional KO mouse, immunofluorescence, synaptic fractionation, mGluR-dependent LTD assay, contextual fear conditioning Molecular neurobiology High 34383253
2022 GOPC is required for correct basolateral targeting of syndecan-1 in polarized MDCK cells via interaction with syndecan-1's full-length PDZ motif; this sorting is not dependent on transmembrane domain or sphingomyelin content. GOPC overexpression also alters Golgi morphology, suggesting GOPC affects sorting indirectly through effects on Golgi organization. siRNA knockdown, domain mutagenesis, trafficking/sorting assay in polarized MDCK cells, Golgi morphology imaging Molecular biology of the cell Medium 35830596
2024 GOPC (PIST) traffics from the Golgi to parasitophorous vacuoles (PVs) during Leishmania major infection and associates with autophagy regulatory protein Beclin 1 within PVs (but not with LC3). siRNA silencing of PIST increases parasite burden; PIST overexpression restricts L. major infectivity, establishing PIST as a regulator of Leishmania infection via the Beclin 1-PI3KC3 autophagy pathway. Immunofluorescence colocalization, co-immunoprecipitation, siRNA knockdown, overexpression, parasite burden quantification ACS infectious diseases Medium 38556987
2025 MC-LR toxin induces proteasomal degradation of GOPC by promoting excessive ubiquitination via dual inhibition of the deubiquitinase UCHL3: MC-LR directly binds the catalytic domain of UCHL3, blocking its interaction with GOPC and inhibiting its enzymatic activity, while also suppressing UCHL3 transcription and destabilizing UCHL3 protein. UCHL3 dysfunction leads to GOPC ubiquitination and destruction, disrupting acrosome biogenesis. In vitro binding assay (MC-LR to UCHL3 catalytic domain), ubiquitination assays, co-immunoprecipitation, transcription analysis, protein stability assays Environmental pollution Medium 40784473
2025 Leishmania GP63 metalloprotease facilitates PIST-Golgin160 complex formation by suppressing caspase-3 activation, thereby preventing Golgin160 cleavage. GP63 recruits PIST to parasitophorous vacuoles and promotes PIST-Beclin1 colocalization while excluding LC3. Co-immunoprecipitation, immunofluorescence, GP63-deficient parasite comparison, caspase inhibitor (Z-VAD-FMK) treatment ACS infectious diseases Medium 41269215
2025 GOPC-ROS1 fusion enhances the catalytic activity of the ROS1 receptor tyrosine kinase fragment and alters the tyrosine phosphorylation profile in human lymphatic endothelial cells. Impaired phosphorylation of ZO-1 at tyrosine 895, due to decreased colocalization of GOPC-ROS1 with ZO-1, inhibits tight junction formation in lymphatic endothelial cells. Phosphoproteomic profiling, overexpression of fusion protein, colocalization assay, ZO-1 phosphorylation site mutagenesis/validation Biochemical pharmacology Medium 40819798
2025 Using affinity purification mass spectrometry, SHP2 was identified in direct interaction with GOPC-ROS1 (and other ROS1 fusion oncoproteins) but not with ALK fusion oncoproteins; ROS1 fusions phosphorylate SHP2 to a greater extent than ALK fusions, suggesting non-canonical SHP2-driven signaling downstream of GOPC-ROS1. Affinity purification mass spectrometry, phosphoproteomics bioRxivpreprint Low bio_10.1101_2025.05.27.656302
2013 The coiled-coil domain of PIST (amino acids 29-133) was crystallized and X-ray diffraction data collected to 4.0 Å resolution (hexagonal space group P6₂22 or P6₄22); this domain is responsible for interaction with Rab6A and fusion with ROS1. Protein crystallization, X-ray diffraction Acta crystallographica Section F Low 23545662

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proceedings of the National Academy of Sciences of the United States of America 232 12149515
2012 Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clinical cancer research : an official journal of the American Association for Cancer Research 147 23052255
2001 PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10. Biochemical and biophysical research communications 80 11162552
2001 Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochemical and biophysical research communications 74 11520064
2005 Interactions with PDZ domain proteins PIST/GOPC and PDZK1 regulate intracellular sorting of the somatostatin receptor subtype 5. The Journal of biological chemistry 64 16012170
2004 Failure to assemble the peri-nuclear structures in GOPC deficient spermatids as found in round-headed spermatozoa. Archives of histology and cytology 45 15700542
2007 Factors maintaining normal sperm tail structure during epididymal maturation studied in Gopc-/- mice. Biology of reproduction 43 17360959
2020 Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation. Cell reports 42 33027661
2005 Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST. The Journal of biological chemistry 40 15951434
2015 The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization. The Journal of biological chemistry 37 25614626
2004 The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice. Archives of histology and cytology 35 15700543
2011 CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC. Journal of cell science 30 21852426
2010 PIST regulates the intracellular trafficking and plasma membrane expression of cadherin 23. BMC cell biology 25 20958966
2019 GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. Journal of neuropathology and experimental neurology 22 31626289
2019 ROS1-GOPC/FIG: a novel gene fusion in hepatic angiosarcoma. Oncotarget 21 30719217
2006 Identification of a PDZ protein, PIST, as a binding partner for Rho effector Rhotekin: biochemical and cell-biological characterization of Rhotekin-PIST interaction. The Biochemical journal 20 16646955
2006 Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin. Protein science : a publication of the Protein Society 19 16882988
2003 CALEB/NGC interacts with the Golgi-associated protein PIST. The Journal of biological chemistry 19 12885772
2017 Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor. Journal of neurosurgery. Pediatrics 17 28387643
2015 Scaffolding protein GOPC regulates tight junction structure. Cell and tissue research 16 25616555
2006 Possible interaction of a Rho effector, Rhotekin, with a PDZ-protein, PIST, at synapses of hippocampal neurons. Neuroscience research 14 16934893
2020 The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells. Molecular metabolism 13 33359402
2021 Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi. JAMA dermatology 12 34076666
2013 Inorganic phosphate modulates the expression of the NaPi-2a transporter in the trans-Golgi network and the interaction with PIST in the proximal tubule. BioMed research international 12 23509734
2005 The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5. FEBS letters 12 16263117
2021 GOPC-ROS1 mosaicism in agminated Spitz naevi: report of two cases. Virchows Archiv : an international journal of pathology 11 33733342
2012 Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system. The Journal of comparative neurology 11 21953547
2013 PIST (GOPC) modulates the oncogenic voltage-gated potassium channel KV10.1. Frontiers in physiology 10 23966943
2020 Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report. The oncologist 9 32652753
2019 Increase of germ cell nuclear factor expression in globozoospermic Gopc-/- knockout mice. Andrology 9 30786176
2021 Nasopharyngeal papillary adenocarcinoma harboring a fusion of ROS1 with GOPC: A case report. Medicine 8 33546077
2021 The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5. Molecular neurobiology 8 34383253
2020 Oncogenic GOPC-ROS1 Fusion Identified in a Congenital Glioblastoma Case. Journal of pediatric hematology/oncology 7 31929384
2016 Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST. Neural plasticity 5 27867666
2022 GOPC facilitates the sorting of syndecan-1 in polarized epithelial cells. Molecular biology of the cell 3 35830596
2024 Role of Macrophage PIST Protein in Regulating Leishmania major Infection. ACS infectious diseases 2 38556987
2025 UCHL3-mediated proteasomal degradation of GOPC drives microcystin-LR-induced acrosomal dysgenesis. Environmental pollution (Barking, Essex : 1987) 1 40784473
2025 Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis. Biochemical pharmacology 1 40819798
2025 GP63 Alters the Macrophage Golgin160-Associated PIST Distribution by Reducing Caspase-3 Expression during Leishmania major Infection. ACS infectious diseases 1 41269215
2021 Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc-/- globozoospermic spermatogenesis. Microscopy research and technique 1 34870349
2013 Crystallization and preliminary X-ray crystallographic studies of the coiled-coil domain of PIST. Acta crystallographica. Section F, Structural biology and crystallization communications 1 23545662
2026 Overexpression of Gopc Promotes Cardiomyocyte Proliferation but Delays Overall Heart Regeneration in Zebrafish. Cell biology international 0 41532421

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