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Showing GIPC1 — GIPC is a alias.

GIPC1

PDZ domain-containing protein GIPC1 · UniProt O14908

Length
333 aa
Mass
36.0 kDa
Annotated
2026-06-10
92 papers in source corpus 43 papers cited in narrative 42 extracted findings
Cross-family judge faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GIPC1 is a cytosolic PDZ-domain scaffolding/adaptor protein that couples the cytoplasmic C-termini of diverse transmembrane receptors to the actin-based motor myosin VI, thereby controlling receptor endocytosis, trafficking, recycling, and signaling output (PMID:9770488, PMID:15975910, PMID:16908842). Through its single PDZ domain it engages defined C-terminal PDZ-binding motifs on a broad array of partners—the RGS protein GAIP/RGS19 (PMID:9770488), GLUT1 (PMID:10198040), TrkA (PMID:11251075), TGF-beta receptors TbetaRIII and endoglin (PMID:11546783, PMID:18775991), integrin alpha-subunits (PMID:11479315, PMID:11852236), dopamine D2/D3 receptors (PMID:14617818), beta1-adrenergic receptor (PMID:12724327), megalin (PMID:11912251), neuropilin-1 and PlexinD1 (PMID:19175293, PMID:28537552), and LPA1 (PMID:23145131)—while its C-terminal myosin-interacting region recruits myosin VI (PMID:15975910). Crystallographic and biophysical work shows GIPC1 forms an autoinhibited domain-swapped dimer; cargo binding to the PDZ domain releases autoinhibition to permit myosin VI engagement and assembly of an alternating GIPC1/myosin VI oligomeric array, and the GIPC1 myosin-interacting region relieves myosin VI autoinhibition to accelerate ensemble cargo transport (PMID:28537552, PMID:35143838). Receptor C-termini bound in the PDZ pocket act in trans to license myosin VI recruitment and couple internalized cargo to uncoated endocytic vesicles, a function required in vivo for correct megalin targeting in renal proximal tubules (PMID:16908842). On this trafficking platform GIPC1 assembles APPL1-containing signaling endosomes that sustain TrkA- and LPA1-driven MEK/ERK and PI3K-Akt signaling and neurite outgrowth (PMID:17000777, PMID:17015470, PMID:23145131), scaffolds GAIP/RGS19 to GPCRs to attenuate Gi-mediated signaling (PMID:15356268, PMID:12724327), and stabilizes cell-surface receptors including beta1-AR and SR-B1 by preventing their ubiquitin- and proteasome/lysosome-mediated degradation (PMID:38458410, PMID:33811857). Beyond plasma-membrane cargo, GIPC1 mediates actin-dependent retrograde transport of the fission GTPase Drp1 to promote mitochondrial fission (PMID:34705526) and of DECR1 into mitochondria to maintain redox homeostasis and suppress ferroptosis (PMID:41787053). Through these activities GIPC1 functions in TGF-beta-dependent EMT and epicardial/endocardial development (PMID:21871877, PMID:21945156), PCP-regulated cochlear hair-cell maturation via Vangl2 trafficking (PMID:22991442), PlexinD1-dependent angiogenesis (PMID:31050647), and cardiac homeostasis, where cardiomyocyte-specific loss causes spontaneous hypertrophy and dysfunction (PMID:38458410).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1998 High

    Established GIPC1 as a PDZ-domain protein with a specific binding partner, defining its founding identity as a selective scaffold rather than a generic adaptor.

    Evidence Yeast two-hybrid, GST pull-down, deletion analysis and immunoelectron microscopy identifying the GAIP/RGS19 SEA-motif interaction and partitioning between cytosolic and vesicle-associated pools

    PMID:9770488

    Open questions at the time
    • Did not establish what cargo the membrane-associated vesicle pool carries
    • No functional consequence for GAIP-mediated GTPase signaling demonstrated
  2. 1999 High

    Showed GIPC1 binds receptor and cytoskeletal/motor partners isoform-specifically, framing it as an adapter that links transmembrane cargo to the cytoskeleton and myosin VI.

    Evidence Yeast two-hybrid, GST pull-down and co-IP with native GLUT1, plus interactions with myosin VI, alpha-actinin-1 and KIF-1B

    PMID:10198040

    Open questions at the time
    • Did not define the domain architecture for motor binding versus cargo binding
    • No direct transport or trafficking assay
  3. 2001 High

    Defined GIPC1 as a multi-receptor PDZ adaptor that regulates receptor surface stability and signaling output across RTKs, TGF-beta receptors, integrins and biosynthetic cargo.

    Evidence Co-IP, expression cloning, peptide binding, cell-surface and reporter assays for TrkA, TbetaRIII, integrin alpha-subunits and gp75/TYRP1

    PMID:11251075 PMID:11441007 PMID:11479315 PMID:11546783 PMID:11852236

    Open questions at the time
    • Mechanism linking PDZ binding to altered surface stability not resolved
    • Whether a single GIPC1 molecule services all cargos or distinct pools dedicated to each
  4. 2003 High

    Demonstrated GIPC1 controls GPCR fate and signaling, sequestering internalized dopamine receptors from lysosomal degradation and attenuating Gi-coupled ERK signaling, with dimerization required for scaffolding.

    Evidence Yeast two-hybrid, pull-down, internalization and signaling assays for D2/D3 receptors and beta1-AR with mutant and pertussis-toxin controls

    PMID:12724327 PMID:14617818

    Open questions at the time
    • Structural basis of the required dimerization not yet defined
    • How GIPC1 selects between recycling and anti-degradative routing unclear
  5. 2004 Medium

    Positioned GIPC1 as an obligatory component of a GPCR-RGS signaling module, showing it recruits GAIP/RGS19 to an active receptor at the membrane.

    Evidence Co-IP, agonist-driven membrane translocation, and GAIP GTPase-dependent functional signaling assays at the dopamine D2 receptor

    PMID:15356268

    Open questions at the time
    • Single lab; reciprocal validation of the translocation mechanism limited
    • Generality across other Gi-coupled receptors not tested here
  6. 2005 High

    Resolved GIPC1 domain logic—separable N-terminal oligomerization and C-terminal myosin VI binding—and showed actin-dependent, microtubule-independent motility of GIPC1/myosin VI complexes is required for cargo (GLUT1) trafficking.

    Evidence Deletion mutant mapping, co-IP, live-cell imaging with cytoskeletal inhibitors, and GLUT1 trafficking assays in polarized epithelia

    PMID:15975910

    Open questions at the time
    • How cargo binding gates motor recruitment not yet structurally explained
    • Directionality and processivity of transport not directly measured
  7. 2006 High

    Established the in trans recruitment model and in vivo necessity: receptor PDZ engagement licenses myosin VI binding to couple cargo to uncoated endocytic vesicles, with megalin mistargeting causing proteinuria in GIPC1-null mice.

    Evidence siRNA, deletion analysis, endocytic assays and GIPC1-null mouse renal phenotype; plus identification of APPL1 endosomal signaling complex with TrkA

    PMID:16908842 PMID:17000777 PMID:17015470

    Open questions at the time
    • How the trans-recruitment is regulated to prevent constitutive motor engagement
    • Whether APPL endosome assembly is mechanistically separable from myosin VI transport
  8. 2008 High

    Extended GIPC1's receptor-stabilizing role to TGF-beta superfamily co-receptors and linked it to pathway-selective Smad signaling and cell migration control.

    Evidence Reciprocal co-IP, colocalization, Smad1/5/8 phosphorylation, reporter and migration assays with endoglin PDZ-motif mutants

    PMID:18775991

    Open questions at the time
    • Mechanism by which GIPC1 biases TGF-beta toward Smad1/5/8 not defined
    • Trafficking step responsible for surface retention not pinpointed
  9. 2009 Medium

    Connected GIPC1/myosin VI-driven integrin endocytosis to neuropilin-1-promoted adhesion and migration, and tied GIPC1-receptor binding to cancer-relevant signaling, invasion suppression and IGF1R protein stability.

    Evidence siRNA with mutant rescue, co-IP, Rab5 endosome live imaging and adhesion assays (NRP1/alpha5beta1); in vivo xenograft and tumor-growth models for TbetaRIII and IGF1R

    PMID:19175293 PMID:19509165 PMID:19955393

    Open questions at the time
    • Whether IGF1R stabilization is a direct trafficking effect or indirect
    • Reconciliation of pro-adhesion versus invasion-suppressive roles across cell types
  10. 2012 High

    Broadened GIPC1's developmental reach—PCP protein Vangl2 trafficking in cochlear hair cells and LPA1 endosomal sorting that restrains Akt-driven proliferation/motility.

    Evidence Co-IP, heterologous trafficking assays, MyoVI mutant mouse and STED microscopy (Vangl2); co-IP, colocalization and siRNA with signaling readouts (LPA1)

    PMID:22991442 PMID:23145131

    Open questions at the time
    • How GIPC1/myosin VI directs asymmetric Vangl2 localization not fully resolved
    • Whether LPA1 sorting outcome generalizes to other GPCRs
  11. 2017 High

    Provided the structural mechanism for autoinhibition and cargo-triggered activation, showing GIPC1 is a domain-swapped dimer whose PlexinD1 binding releases inhibition to permit myosin VI engagement and oligomeric array formation.

    Evidence Multiple apo and bound crystal structures with solution binding and cell-based oligomerization validation

    PMID:28537552

    Open questions at the time
    • Whether all cargos relieve autoinhibition identically
    • Stoichiometry of the transport-competent array in vivo not defined
  12. 2019 High

    Defined GIPC1 as an in vivo negative modulator of antiangiogenic PlexinD1 signaling, acting through endocytic trafficking during vascular development.

    Evidence Zebrafish genetic epistasis between gipc and plxnd1 mutants plus endothelial-cell SEMA-PLXND1 signaling assays

    PMID:31050647

    Open questions at the time
    • Trafficking step that limits PlexinD1 signaling not pinpointed
    • Relationship to angiogenic versus other GIPC1 cargos in endothelium
  13. 2021 Medium

    Showed GIPC1 mediates actin-based retrograde transport of the mitochondrial fission GTPase Drp1 and stabilizes the lipoprotein receptor SR-B1 against degradation, extending its role to organelle dynamics and lipid metabolism.

    Evidence Interactome screening, co-IP, retrograde-transport live imaging and fission assays (Drp1); co-IP in multiple systems and in vivo siRNA with cholesterol-uptake readouts (SR-B1)

    PMID:33811857 PMID:34705526

    Open questions at the time
    • Single-lab findings without reciprocal cross-validation
    • How GIPC1 distinguishes anti-degradative from transport functions for different cargos
  14. 2022 High

    Provided the biophysical mechanism of GIPC1-driven transport, showing its myosin-interacting region relieves myosin VI autoinhibition and accelerates ensemble cargo movement.

    Evidence Reconstituted motility assays, FRET conformational sensors, optical trapping and DNA-origami cargo scaffolds

    PMID:35143838

    Open questions at the time
    • In vivo confirmation of the predicted speed increase on native cargo
    • How cargo identity modulates ensemble size and run length
  15. 2024 High

    Demonstrated a physiological cardiac role: GIPC1 stabilizes beta1-AR against ubiquitin-mediated degradation and restrains MAPK hyperactivation, with cardiomyocyte loss causing spontaneous hypertrophy and dysfunction rescued by overexpression.

    Evidence Conditional knockout and AAV9-rescue mice with echocardiography, histology, co-IP, ubiquitination and MAPK signaling analyses

    PMID:38458410

    Open questions at the time
    • Whether anti-ubiquitination is direct or via trafficking
    • Contribution of beta1/beta2-AR balance versus other GIPC1 cargos to the cardiac phenotype
  16. 2026 High

    Identified a mitochondrial protective function: GIPC1 binds and delivers DECR1 into mitochondria via actin-dependent transport to maintain redox homeostasis and suppress ferroptosis, with cardiac knockout disrupting fatty-acid metabolism.

    Evidence Co-IP/MS, SPR (KD=16.3 nM), docking, cardiac-specific knockout with proteomics/lipidomics and DECR1-overexpression rescue

    PMID:41787053

    Open questions at the time
    • Mechanism of mitochondrial import handoff after actin transport not defined
    • Relationship to the Drp1 transport role in the same compartment

Open questions

Synthesis pass · forward-looking unresolved questions
  • How GIPC1 selects among its dozens of competing PDZ cargos and switches between recycling, anti-degradative stabilization, and retrograde organelle transport in a single cell remains unresolved.
  • No quantitative model of cargo competition for the single PDZ pocket
  • Regulatory inputs that select trafficking versus stabilization outcomes unknown
  • Reported transcription-factor function at the MACC1 promoter not reconciled with the cytoplasmic scaffold role

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 3
Localization
GO:0031410 cytoplasmic vesicle 4 GO:0005768 endosome 3 GO:0005739 mitochondrion 2 GO:0005794 Golgi apparatus 2 GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 3
Partners
ADRB1APPL1DRD3DRP1MYO6NRP1RGS19TGFBR3
Complex memberships
GIPC1/APPL1 signaling endosomeGIPC1/myosin VI transport complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 GIPC1 (GIPC) was identified as a protein with a central PDZ domain that specifically interacts with the C terminus of RGS-GAIP (a GTPase-activating protein for Galphai subunits). The PDZ domain of GIPC binds the unique 11 amino acid C-terminus of GAIP (SEA motif) but does not interact with other RGS family members tested. GIPC exists in two pools: ~70% cytosolic and ~30% membrane-associated, with the membrane pool associating with clusters of vesicles near the plasma membrane. Yeast two-hybrid, GST pull-down assays, deletion mutant analysis, immunofluorescence, immunoelectron microscopy, immunoblotting of membrane fractions Proceedings of the National Academy of Sciences of the United States of America High 9770488
1999 GIPC1 (GLUT1CBP) binds via its PDZ domain to the C terminus of GLUT1 glucose transporter in an isoform-specific manner (not GLUT3 or GLUT4), and also interacts with cytoskeletal proteins myosin VI, alpha-actinin-1, and KIF-1B, implicating GIPC1 as an adapter linking GLUT1 to the cytoskeleton. Yeast two-hybrid, GST pull-down, co-immunoprecipitation with native GLUT1 from cell membranes Molecular biology of the cell High 10198040
2001 GIPC1 binds via its PDZ domain to the juxtamembrane region of TrkA NGF receptor, and together with GAIP forms a coprecipitable complex. GIPC1 colocalizes with phosphorylated TrkA in retrograde transport vesicles in neurites and cell bodies. Overexpression of GIPC1 in PC12 cells decreases NGF-induced ERK1/2 phosphorylation without affecting Akt, PLC-gamma1, or Shc phosphorylation. Co-immunoprecipitation in HEK293T and PC12 cells, immunofluorescence colocalization, overexpression with ERK phosphorylation readout Molecular biology of the cell High 11251075
2001 GIPC1 PDZ domain interacts with a Class I PDZ binding motif in the cytoplasmic domain of TGF-beta type III receptor (TbetaRIII), stabilizing cell surface expression of TbetaRIII and enhancing TGF-beta signaling (inhibition of proliferation and PAI promoter induction). Deletion of the PDZ binding motif abolishes both GIPC binding and the effects on TbetaRIII. Expression cloning, co-immunoprecipitation, cell surface expression assays, proliferation and reporter gene assays with mutant constructs The Journal of biological chemistry High 11546783
2001 GIPC1 PDZ domain binds to the C terminus of integrin alpha6A and alpha6B subunits, and also alpha5 integrin. The alpha6A and alpha5 subunits contain a type I PDZ binding site (TSDA), while alpha6B contains a novel PDZ-binding motif (ESYS) requiring a negatively charged residue at position -1 or -3. GIPC1 and alpha6 integrin colocalize in retraction fibers. Yeast two-hybrid, in vitro binding assays with purified peptides, truncation analysis, immunofluorescence colocalization The Journal of biological chemistry High 11479315 11852236
2001 GIPC1 PDZ domain interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (TRP-1/TYRP1) via the C-terminal SVV residues of gp75. Only newly synthesized gp75 associates with GIPC1 predominantly in the juxtanuclear Golgi region, suggesting a role in biosynthetic sorting to melanosomes. Yeast two-hybrid, co-immunoprecipitation, synchronized biosynthesis assay, immunofluorescence The Journal of biological chemistry Medium 11441007
2002 The Xenopus GIPC homolog (xGIPC) binds to the intracellular domain of the IGF-1 receptor independent of kinase activity. Injection of C-terminal truncation mutants retaining the PDZ domain blocked IGF-1-induced MAP kinase activation and oocyte maturation. Full-length xGIPC enhanced RGS-GAIP stimulation of insulin response in oocytes. Xenopus oocyte injection, yeast two-hybrid or binding assays, MAP kinase activation assay, maturation assay The Journal of biological chemistry Medium 11751850
2002 GIPC1 interacts with megalin (LRP2) in renal proximal tubule epithelial cells. GST-GIPC specifically binds megalin in precipitation assays. GIPC1, GAIP, and Galphai3 cosediment with megalin in brush border and microvillar fractions, and GIPC1 is localized in clathrin-coated pits and apical tubules of endocytic compartments. GST pull-down, cell fractionation, immunoelectron microscopy, immunofluorescence Journal of the American Society of Nephrology Medium 11912251
2003 GIPC1 co-immunoprecipitates with the beta1-adrenergic receptor (beta1-AR) in COS-7 cells via an interaction requiring the Ser residue of the ESKV C-terminal motif. GIPC1 expression substantially decreases beta1-AR-stimulated, Gi-mediated ERK1/2 activation (inhibited by pertussis toxin) but has no effect on receptor sequestration or cAMP accumulation. Yeast two-hybrid, co-immunoprecipitation, cAMP assay, ERK1/2 phosphorylation assay, pertussis toxin treatment The Journal of biological chemistry Medium 12724327
2003 GIPC1 PDZ domain interacts specifically with dopamine D2 and D3 receptors (but not D4 receptor) via their C-terminal sequences. GIPC1 co-internalizes with D2R and D3R, reduces D3R signaling, and sequesters receptors in sorting vesicles to prevent lysosomal degradation. GIPC1 dimerization is required for its scaffolding function. Yeast two-hybrid, pull-down, affinity chromatography with recombinant and endogenous proteins, immunofluorescence colocalization, internalization assays, signaling assays Molecular biology of the cell High 14617818
2003 GIPC1 interacts with human lutropin receptor (hLHR) via its PDZ domain binding to the C-terminal tetrapeptide of hLHR. siRNA knockdown of GIPC1 reduces recycling of internalized hormone and lowers steady-state hLHR density at the cell surface. Yeast two-hybrid, pull-down, co-immunoprecipitation, siRNA knockdown, receptor trafficking assay The Journal of biological chemistry Medium 14507927
2004 GIPC1 is required for recruitment of GAIP (RGS19) to the dopamine D2 receptor at the plasma membrane. D2R activation drives dynamic translocation of GAIP to the plasma membrane via GIPC1 scaffolding. The GTPase activity of GAIP regulates two D2R-mediated responses in a GIPC1-dependent manner, establishing GIPC1 as a required component of a GPCR-RGS signaling complex. Co-immunoprecipitation, membrane translocation assay, functional signaling assays, cell fractionation Molecular biology of the cell Medium 15356268
2005 GIPC1 contains two myosin VI binding domains in its C terminus, with separate N-terminal oligomerization and C-terminal myosin VI binding functions. The myosin VI binding domain is necessary for intracellular interactions with myosin VI and for recruitment of myosin VI to membrane structures. GIPC1/myosin VI complexes move in cellular extensions in an actin-dependent and microtubule-independent manner. Blocking either GIPC1-myosin VI or GLUT1-GIPC1 interactions disrupts GLUT1 trafficking in polarized epithelial cells, reducing plasma membrane GLUT1. Deletion mutant analysis, co-immunoprecipitation, live-cell imaging, pharmacological actin/microtubule inhibitors, GLUT1 trafficking assay in polarized cells Molecular biology of the cell High 15975910
2005 HPV-18 E6 protein interacts with TIP-2/GIPC1 and triggers its polyubiquitination and proteasome-mediated degradation. This reduces GIPC1 levels in HeLa cells and impairs TGF-beta signaling (reduces Id3 induction and antiproliferative effect of TGF-beta). siRNA silencing of E6 restores GIPC1 levels and TGF-beta responsiveness. Co-immunoprecipitation, siRNA knockdown, proteasome inhibitor experiments, reporter gene assay, cell proliferation assay Journal of virology Medium 15767424
2006 GIPC1 (synectin) is required for internalization of cell surface receptors and for coupling of myosin VI to uncoated endocytic vesicles (UCV). The mechanism involves PDZ domain engagement by C termini of internalized receptors (e.g., megalin), which in trans facilitates myosin VI binding to the GIPC1 C terminus outside the PDZ domain. In GIPC1-null mice, megalin is mistargeted in renal proximal tubules causing proteinuria. siRNA knockdown, deletion mutant analysis, in vivo knockout mouse phenotype (proteinuria, megalin mislocalization), endocytic assay Proceedings of the National Academy of Sciences of the United States of America High 16908842
2006 APPL1 is identified as a TrkA-associated protein that binds to GIPC1 via its C-terminal sequence engaging the GIPC1 PDZ domain. APPL1, GIPC1, and phosphorylated TrkA co-enrich in the same endosomal fractions. Knockdown of either APPL1 or GIPC1 suppresses NGF-dependent MEK, ERK, and Akt activation and neurite outgrowth in PC12 cells. Mass spectrometry from rat brain lysate, co-immunoprecipitation in sympathetic neurons, high-resolution endosomal fractionation, siRNA knockdown with signaling and neurite outgrowth readouts Molecular and cellular biology High 17000777
2006 Endogenous GIPC1 binds to the C terminus of APPL (a Rab5 effector) via its PDZ domain. Upon NGF/TrkA activation, GIPC1 and APPL translocate to peripheral endocytic vesicles carrying TrkA. GIPC1's interaction with APPL is essential for GIPC1 recruitment to peripheral endosomes; a GIPC1 PDZ mutant unable to bind APPL inhibits NGF-induced GIPC1 recruitment, MAPK activation, and neurite outgrowth. GIPC1 depletion slows endocytosis and trafficking of TrkA to EEA1 early endosomes. Co-immunoprecipitation, GIPC1 PDZ mutant overexpression, siRNA knockdown, immunofluorescence live tracking, MAPK phosphorylation assay, neurite outgrowth assay Molecular and cellular biology High 17015470
2007 GIPC1 associates with surface and internalized NMDA receptors in heterologous cells and colocalizes with a population of NMDA receptors on the cell surface of neurons. GIPC1 is mainly excluded from synapses. Changes in GIPC1 expression alter the number of surface (extrasynaptic) NMDA receptors without changing total synaptic receptor numbers. Co-immunoprecipitation, immunofluorescence in neurons, surface receptor quantification upon GIPC1 overexpression/knockdown The Journal of neuroscience Medium 17959809
2008 Endoglin interacts with GIPC1 via a Class I PDZ binding motif in the cytoplasmic domain of endoglin. GIPC1 promotes cell surface retention of endoglin in a TGF-beta-independent manner. Endoglin-GIPC1 interaction specifically enhances TGF-beta1-induced Smad 1/5/8 phosphorylation and a Smad 1/5/8 responsive promoter, and inhibits endothelial cell migration; all dependent on the endoglin-GIPC1 interaction. Co-immunoprecipitation, immunofluorescence confocal microscopy, subcellular distribution studies, Smad phosphorylation assay, reporter assay, cell migration assay with PDZ-binding mutant constructs The Journal of biological chemistry High 18775991
2009 Neuropilin-1 (Nrp1) promotes alpha5beta1 integrin-mediated endothelial cell adhesion to fibronectin via its cytoplasmic SEA motif by binding GIPC1. GIPC1 interacts with both Nrp1 and alpha5beta1 integrin and, together with myosin VI, stimulates internalization of active alpha5beta1 into Rab5-positive early endosomes. GIPC1 and Myo6 knockdown reduces active alpha5beta1 endocytosis and EC adhesion to fibronectin. RNA interference, rescue with wild-type and mutant constructs, co-immunoprecipitation, live-cell imaging with Rab5-positive endosome markers, adhesion assays PLoS biology High 19175293
2009 The cytoplasmic domain of TbetaRIII is essential for TbetaRIII-mediated attenuation of TGF-beta signaling and inhibition of breast cancer cell migration/invasion in vitro and tumor progression in vivo. The interaction between the TbetaRIII cytoplasmic domain and GIPC1 is mechanistically required for both TGF-beta signaling attenuation and invasion suppression. In vivo xenograft models, in vitro migration/invasion assays, TbetaRIII cytoplasmic domain deletion/mutant constructs, GIPC1 interaction assays Carcinogenesis Medium 19955393
2009 GIPC1 PDZ domain interaction with IGF-1R is essential for post-translational stability and maintenance of IGF-1R protein levels in pancreatic adenocarcinoma cells. siRNA knockdown of GIPC1 reduces IGF-1R protein levels and decreases cell proliferation. A PDZ domain-targeting peptide (PSQSSSEA) inhibits GIPC1-IGF-1R association and reduces tumor growth in vivo. siRNA knockdown, PDZ peptide inhibition, IGF-1R protein level assay, orthotopic tumor mouse model with bioluminescence Clinical cancer research Medium 19509165
2010 GIPC1 PDZ domain binds to the PDZ-binding motif at the C terminus of MyoGEF (a guanine nucleotide exchange factor). GIPC1 and MyoGEF colocalize at the cell leading edge. RNAi depletion of GIPC1 in MDA-MB-231 cells shifts cells from polarized to rounded morphology and dramatically decreases Matrigel invasion. An anti-MyoGEF peptide antibody blocking GIPC1-MyoGEF complex formation similarly disrupts cell polarization and invasion. In vitro and in vivo binding assays, co-immunoprecipitation, immunofluorescence, RNAi knockdown, Matrigel invasion assay, antibody-mediated complex disruption The Journal of biological chemistry High 20634288
2011 TGFbetaR3 interaction with GIPC1 (via the 3 C-terminal amino acids of TGFbetaR3 required to bind GIPC1) is critical for epicardial cell invasion and proliferation in response to TGFbeta1, TGFbeta2, FGF2, and HMW-HA. Expression of TGFbetaR3 missing the PDZ-binding motif fails to rescue deficits in Tgfbr3-/- cells, while GIPC1 knockdown in wild-type cells decreases invasion. Mouse embryo epicardial cell cultures, TGFbetaR3 mutant rescue constructs, GIPC1 siRNA knockdown, invasion and proliferation assays Developmental biology Medium 21871877
2011 TGFbetaR3 interaction with GIPC1 is absolutely required for TGFbeta2- or BMP-2-stimulated endothelial-to-mesenchymal transformation (EMT) in atrioventricular endocardial cushion explants. TGFbetaR3 lacking the C-terminal GIPC1-binding residues or TGFbetaR3 without its entire cytoplasmic domain fails to support EMT. GIPC1 overexpression enhances EMT while GIPC1 siRNA silencing inhibits it. AVC explant EMT assay, mutant TGFbetaR3 constructs, GIPC1 overexpression and siRNA knockdown Cellular signalling Medium 21945156
2012 Gipc1 interacts with Vangl2 (a core PCP protein), and a myosin VI-Gipc1 complex regulates Vangl2 trafficking in heterologous cells. In MyoVI mutant mouse cochlea, Vangl2 membrane presence is increased. Disruption of Gipc1 function in hair cells causes maturation defects including hair bundle orientation and integrity defects. STED microscopy shows enrichment of Vangl2 on the supporting cell side adjacent to proximal hair cell membrane. Co-immunoprecipitation, heterologous cell trafficking assay, MyoVI mutant mouse analysis, in vivo Gipc1 disruption, STED microscopy Development High 22991442
2012 GIPC1 directly binds the PDZ binding motif (SVV) of LPA1 receptor but not other LPA receptors. LPA1 colocalizes and coimmunoprecipitates with GIPC1 and APPL on APPL signaling endosomes. GIPC1 siRNA depletion disturbs LPA1 trafficking to EEA1 early endosomes and promotes LPA1-mediated Akt signaling, cell proliferation, and cell motility. Co-immunoprecipitation, immunofluorescence colocalization, siRNA knockdown, Akt signaling assay, cell proliferation and motility assays PloS one Medium 23145131
2017 Crystal structures reveal that GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that blocks binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases autoinhibition, enabling myosin VI interaction. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating oligomeric array that underlies GIPC/myosin VI complex oligomerization in solution and cells. Crystal structure determination (multiple structures in apo and bound states), solution binding assays, cell-based validation of oligomerization eLife High 28537552
2019 GIPC proteins negatively modulate PlexinD1 signaling during vascular development. Zebrafish expressing Plxnd1 with impaired GIPC binding show low-penetrance angiogenesis deficits and hypersensitivity to antiangiogenic drugs. gipc mutant zebrafish show angiogenic impairments ameliorated by reducing Plxnd1 signaling. GIPC depletion in cultured endothelial cells potentiates SEMA-PLXND1 signaling, establishing GIPC as a negative modulator of antiangiogenic PLXND1 signaling through endocytic trafficking. Zebrafish CRISPR/endogenous mutation, genetic epistasis (gipc mutant + plxnd1 reduction), GIPC depletion in endothelial cells with SEMA-PLXND1 signaling readout, antiangiogenic drug treatment eLife High 31050647
2020 GIPC1 upregulates IGFBP-3 expression downstream of TGF-beta in hepatic stellate cells via epigenetic mechanisms: GIPC1 increases H3K27 acetylation and decreases H3K27me3 at the IGFBP-3 locus. IGFBP-3 promotes HSC migration through integrin-dependent phosphorylation of Akt. Global IGFBP-3 knockout mice show attenuation of HSC activation and portal pressure in chronic liver injury. mRNA sequencing, qPCR, ELISA, chromatin immunoprecipitation (ChIP), Western blot, siRNA knockdown, in vivo knockout mouse model, Akt phosphorylation assay Cellular and molecular gastroenterology and hepatology Medium 32447051
2021 GIPC1 mediates actin-based retrograde transport of Drp1 (a mitochondrial fission GTPase) toward perinuclear mitochondria. Drp1 interacts with GIPC1 through an atypical C-terminal PDZ-binding motif. Loss of this interaction causes Drp1 cytoplasmic mislocalization and reduced mitochondrial fission despite normal GTPase activity. GIPC1 potentiates Drp1-driven cancer cell proliferation and migration. Proteomic interactome screening, co-immunoprecipitation, live-cell imaging (retrograde transport tracking), mitochondrial fission assay, cell proliferation and migration assays with GIPC1 loss-of-function Molecular biology of the cell Medium 34705526
2021 GIPC1 interacts with SR-B1 (scavenger receptor class B type 1) and stabilizes it by negatively regulating its proteasomal and lysosomal degradation. Co-immunoprecipitation with wild-type and mutant GIPC1 in overexpressing cells, native liver cells, and mouse liver tissues confirms the interaction. GIPC1 overexpression increases SR-B1 protein levels and HDL-cholesterol/CE uptake; GIPC1 silencing in mouse liver reduces SR-B1 levels and elevates plasma TG/TC. Co-immunoprecipitation (wild-type and mutant constructs, native cells, mouse tissues), siRNA knockdown in vivo, overexpression assay, cholesterol uptake assay The Journal of biological chemistry Medium 33811857
2022 The GIPC myosin-interacting region (MIR) releases an autoinhibitory interaction within myosin VI, causing conformational changes including increased lever arm flexibility and increased flexibility of the adaptor-motor linkage. This increases actomyosin association/dissociation rates and stimulates a 2-3 fold increase in ensemble cargo transport speed, while GIPC MIR-myosin VI ensembles yield run lengths similar to forced processive dimers. Motility assays, FRET-based conformational sensors, optical trapping, DNA origami-based cargo scaffolds The Journal of biological chemistry High 35143838
2015 GIPC1 interacts directly with IGF1R and participates in Akt1 activation. In mouse embryonic stem cells, dominant-negative GIPC1 overexpression or GIPC1 knockdown inhibits eye field cell development. Pharmacological inhibition of Akt1 phosphorylation mimics the dominant-negative GIPC1 phenotype, supporting a GIPC1-PI3K-Akt1 pathway in eye field specification. Dominant-negative construct overexpression, siRNA knockdown, co-immunoprecipitation (GIPC1-IGFR), Akt1 inhibitor treatment, directed differentiation assay from mESCs Stem cells Medium 26013465
2016 Drd3 palmitoylation acts as a molecular switch for GIPC1-dependent biased signaling. De-palmitoylation enables Helix-8 of Drd3 to move out into aqueous environment for interaction with GIPC1 PDZ domain. Biochemical studies, live imaging, and mutant protein analysis show that palmitoylation regulates Drd3-GIPC1 interaction and affects receptor trafficking and signaling. Molecular dynamics simulations, biochemical interaction assays, live-cell imaging, palmitoylation mutant analysis Molecular and cellular biology Medium 26787837
2024 GIPC1 interacts with the beta1-adrenergic receptor and stabilizes its expression by preventing ubiquitination and degradation. Cardiomyocyte-specific GIPC1 knockout mice develop spontaneous cardiac hypertrophy, fibrosis, and systolic dysfunction. AAV9-mediated GIPC1 overexpression attenuates isoproterenol-induced pathological cardiac remodeling. GIPC1 maintains the balance of beta1-AR/beta2-AR and inhibits hyperactivation of MAPK signaling. Conditional knockout mice (Myh6-cre), AAV9 overexpression, echocardiography, histology, co-immunoprecipitation, ubiquitination assay, MAPK signaling analysis European journal of pharmacology High 38458410
2023 GIPC1 functions both as a protein binding partner of MACC1 (identified by yeast two-hybrid, mass spectrometry, co-IP, and peptide array) and as a transcription factor binding to the MACC1 promoter (TSS to -60 bp, confirmed by chromatin IP and EMSA). GIPC1 knockdown reduces endogenous MACC1 expression, diminishes MACC1-induced cell migration and invasion, and reduces tumor growth and metastasis in vivo. Yeast two-hybrid, mass spectrometry, co-immunoprecipitation, peptide array, chromatin immunoprecipitation, EMSA, siRNA knockdown, in vivo metastasis model Frontiers in oncology Medium 38144523
2026 GIPC1 interacts with mitochondrial DECR1 (2,4-dienoyl-CoA reductase) via its PDZ domain (co-IP/MS, molecular docking, surface plasmon resonance showing KD=16.3 nM). GIPC1 facilitates actin-dependent transport of DECR1 into mitochondria, maintaining redox homeostasis and suppressing ferroptosis. Cardiac-specific GIPC1 knockout disrupts mitochondrial fatty acid metabolism, increases PUFA-containing phospholipids, and promotes ferroptosis. DECR1 overexpression rescues GIPC1 ablation-induced ferroptosis. Co-IP/mass spectrometry, molecular docking, surface plasmon resonance, co-immunoprecipitation, immunofluorescence, cardiac-specific knockout mouse, proteomic and lipidomic analysis, rescue experiments Cell death and differentiation High 41787053
2009 Interaction of hepatitis B virus core protein (HBc) with human GIPC1 was demonstrated via yeast two-hybrid screening of a human liver cDNA library. The PDZ domain of GIPC1 is sufficient for interaction with HBc, and the putative C-terminal PDZ-interacting motif of HBc is important for this interaction. Yeast two-hybrid screening, deletion analysis of PDZ domain Archives of virology Low 20091192
2011 In human primary melanocytes, GIPC1 interacts with APPL (adaptor protein with PH domain) which co-precipitates with newly synthesized TRP1. APPL exists in a complex with GIPC1 and phospho-AKT. PI3-kinase inhibition abolishes GIPC1-APPL interaction and retards TRP1 in the Golgi. Knockdown of either GIPC1 or APPL inhibits melanogenesis by decreasing tyrosinase protein levels and activity. Co-immunoprecipitation, PI3K inhibitor treatment, siRNA knockdown, tyrosinase activity assay, immunofluorescence Archives of biochemistry and biophysics Medium 21291857
2004 CD93 cytoplasmic tail binds to GIPC1 PDZ domain via a newly identified Class I PDZ-binding domain at the CD93 C terminus. Four positively charged juxtamembrane residues of CD93 stabilize this interaction. A cell-permeable peptide encoding the C-terminal 11 amino acids of CD93 enhances phagocytosis in human monocytes. Yeast two-hybrid, GST fusion protein pull-down assay, cell-permeable peptide treatment, phagocytosis assay Journal of leukocyte biology Medium 15459234
2015 VEGF-A/NRP1 signaling induces co-immunoprecipitable interactions between NRP1 and GIPC1, and complex formation between GIPC1 and Syx (a RhoGEF). GIPC1 or Syx knockdown reduces active RhoA and cell proliferation. Constitutively active RhoA restores proliferation in siVEGF-A cells, and GIPC1/Syx complex disruption by a cell-penetrating peptide inhibits RhoA activation and proliferation. Co-immunoprecipitation, siRNA knockdown, RhoA activity assay, constitutively active RhoA rescue, cell-penetrating peptide disruption, proliferation assay Biology open Medium 26209534

Source papers

Stage 0 corpus · 92 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx. Nature 367 31367039
2009 Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS biology 230 19175293
1998 GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proceedings of the National Academy of Sciences of the United States of America 202 9770488
2001 A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. The Journal of biological chemistry 168 11546783
1999 Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Molecular biology of the cell 167 10198040
2001 GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Molecular biology of the cell 139 11251075
2006 APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Molecular and cellular biology 122 17000777
2006 Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proceedings of the National Academy of Sciences of the United States of America 121 16908842
2020 Expansion of GGC Repeat in GIPC1 Is Associated with Oculopharyngodistal Myopathy. American journal of human genetics 118 32413282
2006 GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. Molecular and cellular biology 117 17015470
2008 Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. The Journal of biological chemistry 102 18775991
2003 GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. The Journal of biological chemistry 85 12724327
2003 Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Molecular biology of the cell 84 14617818
2013 Functional proteomics, human genetics and cancer biology of GIPC family members. Experimental & molecular medicine 83 23743496
2016 GIPC: Glycosyl Inositol Phospho Ceramides, the major sphingolipids on earth. Plant signaling & behavior 76 27074617
2016 CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment. Journal of the National Cancer Institute 73 26757732
2002 GIPC gene family (Review). International journal of molecular medicine 73 12011974
2002 Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. International journal of oncology 71 11836570
2003 GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. The Journal of biological chemistry 68 14507927
2002 Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2. International journal of oncology 68 11836571
2002 GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Journal of the American Society of Nephrology : JASN 66 11912251
2005 Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. Journal of virology 60 15767424
2009 The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling. Carcinogenesis 58 19955393
2004 GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Molecular biology of the cell 58 15356268
2005 GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Molecular biology of the cell 57 15975910
2007 The role of the PDZ protein GIPC in regulating NMDA receptor trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience 56 17959809
2002 GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor. The Journal of biological chemistry 56 11751850
2001 PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B. The Journal of biological chemistry 54 11479315
2021 5' UTR CGG repeat expansion in GIPC1 is associated with oculopharyngodistal myopathy. Brain : a journal of neurology 53 33374016
2012 Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development (Cambridge, England) 50 22991442
2001 PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1). The Journal of biological chemistry 48 11441007
2017 Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex. eLife 43 28537552
2002 The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. Matrix biology : journal of the International Society for Matrix Biology 43 11852236
2009 Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clinical cancer research : an official journal of the American Association for Cancer Research 42 19509165
2002 5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis. Biochemical and biophysical research communications 42 11798178
2006 Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma. Cancer research 41 17079444
2002 Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. International journal of molecular medicine 41 11956658
2004 CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. Journal of leukocyte biology 39 15459234
2012 Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer. ACS chemical biology 37 22292614
2018 NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene 36 29755126
2021 Biophysical analysis of the plant-specific GIPC sphingolipids reveals multiple modes of membrane regulation. The Journal of biological chemistry 34 33785359
2015 A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain. Biochimica et biophysica acta 33 25592838
2012 The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. PloS one 33 23145131
2011 The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Developmental biology 31 21871877
2016 Neuropilin-1 (NRP-1)/GIPC1 pathway mediates glioma progression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 30 27481513
2015 VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Biology open 29 26209534
2020 GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway. Cellular and molecular gastroenterology and hepatology 28 32447051
2011 Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. Cellular signalling 27 21945156
2010 Therapeutic implications of GIPC1 silencing in cancer. PloS one 26 21209904
2018 NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival. Molecular carcinogenesis 21 30456845
2014 CD93 and GIPC expression and localization during central nervous system inflammation. Neural regeneration research 21 25598782
2010 GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. The Journal of biological chemistry 20 20634288
2010 GIPC mediates the generation of reactive oxygen species and the regulation of cancer cell proliferation by insulin-like growth factor-1/IGF-1R signaling. Cancer letters 19 20206441
2008 Native human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovary. BMC cancer 19 18721484
2008 A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen. BMC cancer 19 18721486
2019 GIPC proteins negatively modulate Plexind1 signaling during vascular development. eLife 18 31050647
2021 Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport. Molecular biology of the cell 17 34705526
2014 Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth. Molecular cancer therapeutics 17 25125675
2011 Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK. Genes, chromosomes & cancer 17 21432940
2013 Intraosseous correction of misdirected cannulated screws and fracture malalignment using a bent tip 2.0 mm guidewire: technique and indications. Archives of orthopaedic and trauma surgery 16 23589066
2015 The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. Stem cells (Dayton, Ohio) 15 26013465
2010 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. PloS one 15 20574526
2009 Interaction of hepatitis B virus core protein with human GIPC1. Archives of virology 15 20091192
2021 The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake. The Journal of biological chemistry 14 33811857
2020 Strength and duration of GIPC-dependent signaling networks as determinants in cancer. Neoplasia (New York, N.Y.) 13 33360508
2017 TiP2O7 and Expanded Graphite Nanocomposite as Anode Material for Aqueous Lithium-Ion Batteries. ACS applied materials & interfaces 12 28212003
2006 TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes. Archives of biochemistry and biophysics 12 16962991
2019 Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects. Scientific reports 11 31664117
2023 GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling. Oncology research 10 38186571
2022 Multimodal regulation of myosin VI ensemble transport by cargo adaptor protein GIPC. The Journal of biological chemistry 8 35143838
2016 A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling. Molecular and cellular biology 8 26787837
2011 Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes. Archives of biochemistry and biophysics 8 21291857
2023 Overexpression of a GIPC glycosyltransferase gene, OsGMT1, suppresses plant immunity and delays heading time in rice. Plant science : an international journal of experimental plant biology 7 36948404
2024 Overexpressing of the GIPC1 protects against pathological cardiac remodelling. European journal of pharmacology 6 38458410
2025 RELM-β Augmented Hypoxia-Induced Pulmonary Hypertension Through Interacting with GIPC1, OR1N1 and CLIC4. Cardiovascular drugs and therapy 4 41317264
2022 Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation. Annals of clinical and laboratory science 4 36197773
2021 Pressure and Chemical Unfolding of an α-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1. International journal of molecular sciences 4 33808390
2020 Depletion of gipc-1 and gipc-2 causes infertility in Caenorhabditis elegans by reducing sperm motility. Biochemical and biophysical research communications 4 33280819
2005 [Analysis of polymorphic variants of gene GIPC1 CGG repeats in healthy individuals and in patients with breast cancer and non-small cell lung cancer]. Genetika 4 16240642
2025 Automated mass spectrometry-based profiling of multi-glycosylated glycosyl inositol phospho ceramides (GIPC) reveals specific series GIPC rearrangements during barley grain development and heat stress response. The Plant journal : for cell and molecular biology 3 40570361
2023 GIPC1 regulates MACC1-driven metastasis. Frontiers in oncology 3 38144523
2024 The Actin Motor Protein Myosin 6 Contributes to Cell Migration and Expression of GIPC1 and Septins in Breast Cancer Cells. Cancer management and research 2 39445095
2007 [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. Verhandlungen der Deutschen Gesellschaft fur Pathologie 2 18314626
2026 GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis. International journal of biological sciences 1 41522336
2025 Lipid Nanoparticle-Mediated RNAi Against GIPC1 Overcomes Chemoresistance in Pancreatic Ductal Adenocarcinoma. Pharmaceutics 1 41155969
2025 Linking Megalin, Cubilin, Caveolin-1, GIPC1 and Dab2IP Expression to Ocular Tumorigenesis: Profiles in Retinoblastoma, Choroidal Melanoma, and the Normal Human Eye. Cancers 1 41374987
2024 Immunoexpression Patterns of Megalin, Cubilin, Caveolin-1, Gipc1 and Dab2IP in the Embryonic and Postnatal Development of the Kidneys in Yotari (Dab1-/-) Mice. Biomedicines 1 39062115
2012 Impact of the adaptor protein GIPC1/Synectin on radioresistance and survival after irradiation of prostate cancer. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 1 23128896
2026 GIPC1 governed ferroptosis by regulating DECR1-modulating lipid homeostasis during dilated cardiomyopathy (DCM). Cell death and differentiation 0 41787053
2026 Neuronal and glial intranuclear inclusions in a patient with oculopharyngodistal myopathy associated with noncoding GGC repeat expansions in GIPC1. Clinical neuropathology 0 42057638
2025 Chemical Synthesis and Structural Determination of the Inositol Glycan Head of Plant Sphingolipid GIPC in Brassicaceae. Chemistry (Weinheim an der Bergstrasse, Germany) 0 40708454
2022 Human-induced pluripotent stem cell line (FDHSi001-A) derived from a patient with a CGG repeat expansion in the 5'UTR of GIPC1. Stem cell research 0 36055118

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