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Showing GDPD5 — GDE2 is a alias.

GDPD5

Glycerophosphodiester phosphodiesterase domain-containing protein 5 · UniProt Q8WTR4

Length
605 aa
Mass
68.6 kDa
Annotated
2026-06-10
33 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GDPD5 (GDE2) is a six-transmembrane plasma-membrane enzyme that drives neuronal differentiation and maintains neuronal survival through extracellular cleavage of GPI-anchored proteins (PMID:16195461, PMID:23329048, PMID:28103900). Although originally defined as a glycerophosphocholine phosphodiesterase that degrades GPC to glycerol-3-phosphate and choline (PMID:18667693), its neurogenic activity depends on a distinct GPI-anchor cleavage activity that releases substrates such as RECK and the glypicans GPC4/GPC6 from the cell surface (PMID:23329048, PMID:27693046, PMID:28103900). By shedding GPI-anchored RECK, GDE2 disinhibits ADAM protease-dependent shedding of Delta-like 1, inactivating Notch signaling to promote subtype-specific motor neuron and cortical neuron production (PMID:21943603, PMID:23329048, PMID:22951639). GDE2 catalytic activity is gated by redox- and phosphorylation-dependent control: Prdx1 activates the enzyme by reducing an inhibitory intramolecular disulfide bridging its N- and C-terminal domains (PMID:19766572), Prdx4-mediated oxidation of cysteines in the catalytic domain traps GDE2 in the ER and blocks surface trafficking (PMID:25943695), and a C25-C571 disulfide, T587 dephosphorylation, and a CDK1-dependent modification inhibit GPC-PDE activity (PMID:23589856); C-terminal tail motifs further govern constitutive endocytosis and recycling required for productive substrate cleavage (PMID:31932507). Postnatally GDE2 controls neuronal survival (PMID:28103900), oligodendrocyte maturation through neuronal Wnt activation and via cell-autonomous action in oligodendrocytes (PMID:32375055, PMID:33095500), hippocampal synaptic plasticity through restraint of PI3K-AKT-GSK3 signaling (PMID:40634123), and amyloid precursor protein processing by relieving RECK-mediated ADAM10 inhibition to favor non-amyloidogenic sAPPα generation (PMID:33731436). Intracellular mislocalization of GDE2 with retained membrane RECK is observed in Alzheimer's disease tissue, and reduced membrane GDE2 with impaired GPI-anchored protein release occurs in ALS, where GDE2 reduction exacerbates motor neuron degeneration (PMID:33731436, PMID:35550203).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2005 High

    Established that GDE2 is a transmembrane protein whose extracellular catalytic activity is necessary and sufficient to drive spinal motor neuron differentiation, defining it as an enzymatic regulator of neurogenesis.

    Evidence In vivo gain- and loss-of-function plus active-site mutagenesis in chick and mouse spinal cord

    PMID:16195461

    Open questions at the time
    • Did not identify the physiological substrate
    • Mechanism downstream of catalysis unresolved
  2. 2008 High

    Assigned a defined enzymatic activity by showing GDPD5 is a glycerophosphocholine phosphodiesterase, linking it to choline/phospholipid metabolism.

    Evidence In vitro enzymatic assay on immunoprecipitated protein with siRNA and overexpression in IMCD-3 cells

    PMID:18667693

    Open questions at the time
    • Did not connect GPC-PDE activity to the neuronal differentiation function
    • Did not test GPI-anchored substrates
  3. 2009 High

    Revealed redox-based activation, showing Prdx1 reduces an inhibitory intramolecular disulfide to switch GDE2 on, identifying the first regulatory mechanism of the enzyme.

    Evidence Reciprocal co-IP, disulfide-bond mutagenesis, Prdx1 KO mice, and differentiation assays

    PMID:19766572

    Open questions at the time
    • Did not define the catalytic substrate driving differentiation
    • Upstream control of Prdx1-GDE2 coupling unknown
  4. 2010 Medium

    Placed GDE2 in a heterotrimeric G-protein context by identifying GDP-Gαi2 as an interacting partner that regulates motor neuron differentiation.

    Evidence Co-IP and in vivo complex disruption with Gαi2 KO mice and motor neuron counting

    PMID:20197066

    Open questions at the time
    • Mechanism by which Gαi2 modulates GDE2 catalysis unclear
    • Single lab
  5. 2013 High

    Resolved how GDE2 controls neurogenesis by demonstrating it cleaves GPI anchors to release RECK, disinhibiting ADAM-dependent Dll1 shedding and Notch inactivation — reframing the enzyme as a GPI-anchor protease.

    Evidence GPI-anchor cleavage assays, fractionation, active-site mutagenesis, and epistasis with RECK/ADAM/Dll1-Notch

    PMID:23329048

    Open questions at the time
    • Did not enumerate the full GPI-anchored substrate repertoire
    • Relationship between GPI-cleavage and GPC-PDE activities unresolved
  6. 2013 High

    Mapped post-translational control of GPC-PDE activity, identifying a C25-C571 disulfide, T587 phosphorylation, and a CDK1-dependent modification as osmotic stress-responsive regulatory switches.

    Evidence Site-directed mutagenesis, CDK1 inhibition, antioxidant treatment, MS of PTMs, and in vitro activity assays

    PMID:23589856

    Open questions at the time
    • Whether these PTMs also gate GPI-anchor cleavage not tested
    • Kinase/phosphatase identities for T587 not all defined
  7. 2012 Medium

    Extended GDE2 function beyond motor neurons by showing it times cortical progenitor cell-cycle exit via Notch, broadening its developmental role.

    Evidence Gde2 KO mouse with BrdU birthdating, immunohistochemistry, and Notch readouts

    PMID:22951639

    Open questions at the time
    • Substrate driving cortical Notch suppression not identified here
    • Single lab
  8. 2015 High

    Identified ER-based trafficking control, showing Prdx4 oxidizes GDE2 catalytic cysteines to block its surface delivery and neurogenic function.

    Evidence Prdx4 KO mouse, biochemical oxidation assays, trafficking fractionation, and cysteine mutagenesis

    PMID:25943695

    Open questions at the time
    • How oxidation status is reversed at the membrane unclear
    • Relationship to Prdx1 activation step not integrated
  9. 2016 High

    Demonstrated GDE2 acts in cancer by cleaving GPI-anchored glypican-6 to drive neuroblastoma differentiation and shift Rac/RhoA balance, generalizing the GPI-cleavage mechanism to glypican substrates.

    Evidence GPI-cleavage and GPC6 release assays, active-site mutagenesis, Rac/RhoA activity, and differentiation assays

    PMID:27693046

    Open questions at the time
    • Link between glypican release and cytoskeletal GTPase output not fully mechanistic
    • Single lab
  10. 2017 High

    Separated developmental from maintenance roles by showing postnatal GDE2 loss causes progressive neuronal degeneration with impaired glypican-4/6 processing as molecular correlates.

    Evidence Constitutive and conditional Gde2 KO mice with histology, electrophysiology, behavior, and GPI-anchored substrate proteomics

    PMID:28103900

    Open questions at the time
    • Causal substrate for survival defect not isolated
    • Cell-autonomous vs non-autonomous survival mechanism not resolved
  11. 2020 High

    Connected neuronal GDE2 to glial development, showing it activates neuronal Wnt to secrete factors (including phosphacan) that promote oligodendrocyte maturation.

    Evidence Global and neuron-specific Gde2 KO, conditioned medium, Wnt reporters, and genetic Wnt rescue

    PMID:32375055

    Open questions at the time
    • GPI substrate linking GDE2 catalysis to Wnt activation not defined here
    • Identity of all secreted pro-maturation factors incomplete
  12. 2020 Medium

    Showed a cell-autonomous, opposite-direction role in oligodendrocytes where GDE2 slows maturation, indicating cell-type-specific outputs of the same enzyme.

    Evidence Oligodendrocyte-specific Cre-lox KO with myelin immunohistochemistry and primary cultures

    PMID:33095500

    Open questions at the time
    • Substrate in oligodendrocytes not identified
    • Single lab
  13. 2020 High

    Defined trafficking determinants, showing C-terminal motifs controlling endocytosis/recycling are required for GPC6 cleavage and function.

    Evidence Live-cell imaging, FRAP, C-terminal mutagenesis, GPC6 cleavage, and differentiation assays

    PMID:31932507

    Open questions at the time
    • Endocytic adaptors recognizing the motif not identified
    • Single lab
  14. 2021 High

    Linked GDE2 to Alzheimer's disease by showing it promotes ADAM10 α-secretase APP processing through RECK shedding, with intracellular GDE2 sequestration and elevated membrane RECK in AD tissue.

    Evidence Gde2 KO mouse, RECK genetic reduction rescue, APP processing biochemistry, and human AD postmortem analysis

    PMID:33731436

    Open questions at the time
    • Cause of GDE2 intracellular sequestration in AD unknown
    • Therapeutic reversibility not addressed
  15. 2022 Medium

    Implicated GDE2 mislocalization in ALS, showing reduced membrane GDE2 and impaired GPI-anchored protein release, with GDE2 reduction worsening SOD1G93A degeneration.

    Evidence Human ALS postmortem fractionation/IHC, SOD1G93A genetic interaction, and TMT-MS of CSF

    PMID:35550203

    Open questions at the time
    • Mechanism driving membrane loss/intracellular accumulation unknown
    • Single lab
  16. 2024 Medium

    Revealed a context outside neurons in which PRKDC binds GDE2 to stabilize GNAS, activate AKT, and confer doxorubicin resistance in osteosarcoma.

    Evidence CRISPR kinome screen, co-IP, protein stability assays, phospho-AKT, and xenograft/organoid rescue

    PMID:38900943

    Open questions at the time
    • Whether GDE2 catalytic activity is required for this role untested
    • Single lab
  17. 2024 Medium

    Showed GDE2 GPI-anchor cleavage shapes neuronal small extracellular vesicle number and composition, extending its surface-remodeling role to EV biology.

    Evidence Gde2 KO neurons with sEV isolation, quantification, and proteomic profiling

    PMID:39272985

    Open questions at the time
    • Functional consequences of altered sEV populations not established
    • Single study
  18. 2025 Medium

    Tied GDE2 to nuclear integrity and TDP-43 homeostasis, showing restraint of GPC6-driven neuronal Wnt prevents nuclear pore disruption and TDP-43 mislocalization.

    Evidence In vivo Gde2KO with GPC6 genetic reduction rescue, NPC and Ran-NCT assays, TDP-43 IHC, and Wnt reporters (preprint)

    PMID:bio_10.1101_2025.09.24.678385

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Direct link between Wnt activation and NPC disruption mechanistically incomplete
  19. 2025 Medium

    Established a synaptic plasticity role, showing GDE2 restrains PI3K-AKT-GSK3 signaling required for normal hippocampal CA1 morphology and NMDAR-dependent LTD.

    Evidence Gde2 KO mouse electrophysiology, dendritic morphology, pathway biochemistry, and PI3K inhibition rescue

    PMID:40634123

    Open questions at the time
    • GPI substrate upstream of PI3K-AKT-GSK3 not identified
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How GDE2's dual GPC-phosphodiesterase and GPI-anchor protease activities are coordinated, and what determines its substrate selection and disease-associated intracellular trapping, remains unresolved.
  • Structural basis for dual substrate specificity unknown
  • Cause of GDE2 mislocalization in ALS/AD undefined
  • Full GPI-anchored substrate repertoire incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 3 GO:0016787 hydrolase activity 2 GO:0140098 catalytic activity, acting on RNA 2
Localization
GO:0005886 plasma membrane 4 GO:0005783 endoplasmic reticulum 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 3 R-HSA-112316 Neuronal System 2 R-HSA-1643685 Disease 2
Partners
GNAI2GNASGPC6PRDX1PRDX4PRKDCRECK

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 GDE2 (GDPD5) is a six-transmembrane protein that is necessary and sufficient to drive spinal motor neuron differentiation in vivo; a single amino acid mutation in the extracellular catalytic domain abolishes protein function, demonstrating that glycerophosphodiester metabolism in the extracellular domain is required. In vivo gain- and loss-of-function experiments in chick and mouse spinal cord; active-site mutagenesis Science High 16195461
2008 GDPD5 functions as a glycerophosphocholine phosphodiesterase (GPC-PDE) that degrades GPC to glycerol-3-phosphate and choline; recombinant GDPD5 immunoprecipitated from HEK293 cells degrades GPC in vitro, and siRNA knockdown increases cellular GPC levels, while overexpression decreases GPC. In vitro enzymatic assay with immunoprecipitated recombinant protein; siRNA knockdown; overexpression in IMCD-3 cells Proceedings of the National Academy of Sciences of the United States of America High 18667693
2009 Peroxiredoxin 1 (Prdx1) interacts with GDE2 and activates it by reducing an intramolecular disulfide bond bridging the intracellular N- and C-terminal domains; GDE2 variants incapable of disulfide bond formation become constitutively active and independent of Prdx1. Co-immunoprecipitation; disulfide bond mutagenesis; loss-of-function genetics (Prdx1 KO mice); motor neuron differentiation assays Cell High 19766572
2011 GDE2, expressed in postmitotic motor neurons, induces motor neuron generation through a non-cell-autonomous mechanism: its extracellular glycerophosphodiester phosphodiesterase activity inhibits Notch signaling in adjacent motor neuron progenitors, controlling subtype-specific motor neuron production. Gde2 knockout mouse analysis; histology; epistasis with Notch pathway Neuron High 21943603
2013 GDE2 cleaves GPI anchors (unlike classical GDPDs which cleave glycerophosphodiesters) and uses this GPI-anchor cleavage activity to release RECK from the membrane; RECK release disinhibits ADAM protease-dependent shedding of Delta-like 1 (Dll1), leading to Notch inactivation and neurogenesis. GPI-anchor cleavage assay; biochemical fractionation; epistasis with RECK, ADAM proteases, and Dll1-Notch pathway; active-site mutagenesis Science High 23329048
2013 High NaCl and high urea inhibit GDPD5 GPC-PDE activity via at least three post-translational modifications: (i) formation of a disulfide bond between C25 and C571 (promoted by ROS); (ii) dephosphorylation of T587 (constitutively phosphorylated, and dephosphorylation reduces activity); (iii) an additional modification mediated by CDK1. These PTMs collectively increase cellular GPC levels. Site-directed mutagenesis (C25S/C571S, T587A); CDK1 pharmacological inhibition; antioxidant treatment; in vitro GPC-PDE activity assays; mass spectrometry of PTMs Proceedings of the National Academy of Sciences of the United States of America High 23589856
2015 Prdx4, an ER-resident H2O2-metabolizing enzyme, oxidizes two cysteine residues within the GDE2 enzymatic domain via Prdx4 dimers generated by H2O2 metabolism; this oxidation blocks GDE2 trafficking to the plasma membrane and prevents its neurogenic function. Prdx4 knockout mouse; biochemical oxidation assays; subcellular fractionation/trafficking assays; motor neuron differentiation readouts; cysteine mutagenesis Nature communications High 25943695
2010 GDP-bound Gαi2 interacts with GDE2 in motor neuron progenitors; disruption of the GDE2/Gαi2 complex in vivo causes motor neuron deficits analogous to Gαi2 ablation, indicating Gαi2 regulates motor neuron differentiation in part through this interaction. Co-immunoprecipitation; in vivo dominant-negative and knockdown in chick spinal cord; Gαi2 KO mice; motor neuron counting Developmental biology Medium 20197066
2012 Gde2 controls the timing of cortical progenitor cell-cycle exit; in Gde2 knockout mice, cortical progenitors fail to exit the cell cycle on time, correlating with elevated Notch signaling, causing deficits in deep-layer neurons and excess superficial-layer neurons. Gde2 knockout mouse; BrdU birthdating; immunohistochemistry; Notch signaling assays Development Medium 22951639
2016 GDE2 induces neuroblastoma cell differentiation and suppresses cell motility by cleaving (in cis) the GPI-anchored glypican-6 (GPC6) and releasing it from the membrane; a single point mutation in the ectodomain abolishing catalytic activity also abolishes GDE2 differentiation function, and GDE2 alters the Rac-RhoA activity balance. GPI-anchor cleavage assay; active-site mutagenesis; GPC6 surface-release experiments; Rac/RhoA activity assays; neuroblastoma cell differentiation assays Cancer cell High 27693046
2017 Adult mice lacking GDE2 develop progressive neuronal degeneration; conditional deletion of GDE2 after embryonic neurogenesis still causes degeneration, showing the survival function is distinct from the differentiation function. Unbiased screening identifies impaired processing of GPI-anchored Glypican 4 and 6 as molecular correlates. Constitutive and conditional (postnatal) Gde2 KO mouse; histology; electrophysiology; behavioral assays; proteomics screen for GPI-anchored substrates Molecular neurodegeneration High 28103900
2020 GDE2 expressed in neurons activates canonical Wnt signaling, leading to secretion of soluble factors (including phosphacan) that promote oligodendrocyte maturation; Gde2KO neurons show reduced Wnt signaling and genetic activation of Wnt in Gde2KO neurons rescues oligodendrocyte maturation both in vivo and in vitro. Global and neuron-specific Gde2 KO mice; conditioned medium experiments; Wnt signaling reporter assays; genetic rescue with constitutively active Wnt components; phosphacan quantification Cell reports High 32375055
2020 GDE2 expressed in oligodendrocytes cell-autonomously slows the pace of oligodendrocyte maturation; oligodendrocyte-specific Gde2 KO mice show accelerated oligodendrocyte maturation and increased myelination, phenocopied in purified primary oligodendrocyte cultures. Oligodendrocyte-specific Cre-lox KO (O-Gde2KO); immunohistochemistry for myelin proteins; primary oligodendrocyte cultures Developmental dynamics Medium 33095500
2020 GDE2 trafficking is regulated by C-terminal tail sequences that control constitutive endocytosis and recycling; a C-terminal leucine residue in a unique motif is essential for GDE2 internalization, and a truncation mutant with aberrant recycling fails to cleave GPI-anchored GPC6 and is non-functional, whereas a consecutive deletion causing surface retention gains function. Live-cell imaging; FRAP; C-terminal deletion/truncation mutagenesis; GPC6 cleavage assay; neuronal differentiation assays Journal of cell science High 31932507
2021 GDE2 stimulates ADAM10 α-secretase cleavage of amyloid precursor protein (APP) by shedding and inactivating the GPI-anchored RECK protein, a known ADAM10 inhibitor; genetic ablation of GDE2 elevates membrane-bound RECK, reduces sAPPα generation, increases Aβ, and causes synaptic protein loss. In Alzheimer's disease tissue, GDE2 is abnormally sequestered intracellularly and membrane RECK is elevated. Gde2 KO mouse; RECK genetic reduction rescue experiments; APP processing biochemical assays (sAPPα, Aβ measurements); human AD postmortem tissue analysis; synaptic protein quantification Science translational medicine High 33731436
2022 In ALS patient post-mortem tissue, total GDE2 protein levels are normal but membrane GDE2 is substantially reduced, with GDE2 aberrantly accumulating in intracellular compartments of motor cortex neurons; haplogenetic reduction of GDE2 exacerbates motor neuron degeneration in SOD1G93A mice; tandem-mass-tag MS reveals reduced GPI-anchored protein release into CSF of ALS patients. Human ALS postmortem tissue immunohistochemistry and fractionation; SOD1G93A mouse genetic interaction; tandem-mass-tag mass spectrometry of CSF Acta neuropathologica communications Medium 35550203
2024 GDE2 regulates the number and molecular composition of small extracellular vesicles (sEVs) released from neuronal cell surfaces via its GPI-anchor cleavage activity; proteomic profiling identifies at least two distinct GDE2-dependent sEV populations—one containing GDE2 itself and one harboring CD9 and BSG—enriched in cytoskeletal, actin-remodeling, synaptic, and redox proteins. Gde2 KO neurons; sEV isolation and quantification; proteomic profiling (mass spectrometry); functional GPI-cleavage activity assays Cells Medium 39272985
2024 PRKDC recruits and binds GDE2; this interaction enhances GNAS protein stability, which activates AKT phosphorylation and confers doxorubicin resistance in osteosarcoma. CRISPR kinome screen; co-immunoprecipitation; protein stability assays; phospho-AKT measurements; xenograft and organoid rescue experiments Cancer research Medium 38900943
2025 GDE2 regulates hippocampal CA1 synaptic morphology and function; Gde2KO mice show increased dendritic complexity, excess mushroom spines, increased mEPSC frequency, impaired paired-pulse facilitation, and disrupted NMDAR-mediated LTD. Mechanistically, abnormal activation of the PI3K-AKT-GSK3 signaling pathway in Gde2KO hippocampus underlies LTD impairment, and PI3K inhibition restores LTD to WT levels. Gde2 KO mouse; electrophysiology (mEPSC, PPF, LTD); dendritic morphology analysis; PI3K-AKT-GSK3 pathway biochemistry; pharmacological PI3K inhibition rescue eNeuro Medium 40634123
2025 GDE2 inhibits excessive neuronal Wnt activation by regulating the surface expression of GPI-anchored Glypican 6 (GPC6); elevated GPC6 surface expression potentiates neuronal Wnt activation, causing nuclear pore complex disruption, altered Ran-dependent nucleocytoplasmic trafficking, and TDP-43 mislocalization; genetic reduction of GPC6 in Gde2KO mice rescues all these defects. In vivo mouse genetics (Gde2KO, GPC6 genetic reduction rescue); nuclear pore complex integrity assays; Ran-NCT assays; TDP-43 localization immunohistochemistry; Wnt signaling reporters bioRxivpreprint Medium bio_10.1101_2025.09.24.678385

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science (New York, N.Y.) 97 23329048
2009 The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell 94 19766572
2008 GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proceedings of the National Academy of Sciences of the United States of America 81 18667693
2005 Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science (New York, N.Y.) 74 16195461
2020 GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation. Cell reports 58 32375055
2018 GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 57 29635904
2021 Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells. European journal of clinical investigation 54 33797091
2016 Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer cell 50 27693046
2015 Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nature communications 47 25943695
2012 Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR in biomedicine 46 22279038
2011 GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron 42 21943603
2021 GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein. Science translational medicine 35 33731436
2016 Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion. NMR in biomedicine 32 27356959
2004 Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Gene 32 15276213
2007 Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS letters 30 17275818
2012 Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation. Development (Cambridge, England) 29 22951639
2024 PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT. Cancer research 28 38900943
2020 Long noncoding RNA MAGI2-AS3/miR-218-5p/GDPD5/SEC61A1 axis drives cellular proliferation and migration and confers cisplatin resistance in nasopharyngeal carcinoma. International forum of allergy & rhinology 27 32450008
2017 GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Molecular neurodegeneration 22 28103900
2014 Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer model in vivo as monitored by (31) P MRS. NMR in biomedicine 18 24764256
2007 Cloning and characterization of a human GDPD domain-containing protein GDPD5. Molecular biology reports 15 17578682
2022 The distribution and function of GDE2, a regulator of spinal motor neuron survival, are disrupted in Amyotrophic Lateral Sclerosis. Acta neuropathologica communications 12 35550203
2020 Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation. Journal of cell science 11 31932507
2013 High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America 10 23589856
2020 GDE2 expression in oligodendroglia regulates the pace of oligodendrocyte maturation. Developmental dynamics : an official publication of the American Association of Anatomists 9 33095500
2017 Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish. The international journal of biochemistry & cell biology 9 29203233
2024 Loss of GDE2 leads to complex behavioral changes including memory impairment. Behavioral and brain functions : BBF 7 38575965
2024 KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5. The FEBS journal 5 38924469
2022 MiR-874-3p represses the migration and invasion yet promotes the apoptosis and cisplatin sensitivity via being sponged by long intergenic non-coding RNA 00922 (LINC00922) and targeting Glycerophosphodiester Phosphodiesterase Domain Containing 5 (GDPD5) in gastric cancer cells. Bioengineered 5 35282764
2010 GDP-bound Galphai2 regulates spinal motor neuron differentiation through interaction with GDE2. Developmental biology 5 20197066
2024 The Six-Transmembrane Enzyme GDE2 Is Required for the Release of Molecularly Distinct Small Extracellular Vesicles from Neurons. Cells 2 39272985
2026 GDPD5-CD55-EGFR competitive binding axis regulates radioresistance and lipid accumulation in rectal cancer. Cell death & disease 0 41946696
2025 Novel Roles of the GPI-Anchor Cleaving Enzyme, GDE2, in Hippocampal Synaptic Morphology and Function. eNeuro 0 40634123

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