Affinage

GAS7

Growth arrest-specific protein 7 · UniProt O60861

Length
476 aa
Mass
54.4 kDa
Annotated
2026-06-10
46 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GAS7 is an F-BAR/FCH domain-containing cytoskeletal regulator that couples membrane remodeling to actin and microtubule dynamics during cellular morphogenesis (PMID:11795944, PMID:31628328). It binds F-actin directly through its C-terminal domain, localizes to membrane ruffles, and promotes actin assembly and filament crosslinking to drive membrane outgrowth (PMID:11795944), while its F-BAR domain forms two-dimensional sheet-like assemblies on flat membranes via unique hydrophilic loops that are required for phagocytic cup formation in macrophages (PMID:31628328). GAS7 also stabilizes tubulin sheet intermediates to promote processive microtubule elongation (PMID:19580814). In neurons, GAS7 physically interacts with N-WASP through its WW-Pro module and recruits the Arp2/3 complex in a Cdc42-independent manner to generate membrane protrusions, neurite outgrowth, and activity-dependent dendritic spine initiation, the latter requiring an intact F-BAR domain and PI3K signaling (PMID:20150425, PMID:36963834). These activities underlie its established role in neuronal morphological differentiation, including NGF-promoted neurite outgrowth (PMID:9736752, PMID:14515354), and Gas7-deficient mice display motor neuron loss and neuromuscular defects (PMID:22662195). Distinct isoforms with different domain content (FCH-only versus WW+FCH) elicit lamellipodia versus filopodia (PMID:15948147). GAS7 additionally localizes to mitochondria and controls mitochondrial morphology through the PINK1/Drp-1/Mfn-2 axis (PMID:32161906), and in cancer it acts as a metastasis suppressor by associating with CYFIP1/WAVE2 to block CYFIP1–Rac1 interaction and integrin/FAK/Src signaling (PMID:29706651, PMID:33602789). GAS7 expression and stability are tuned by p53 (PMID:29706651), Sp1 (PMID:37769891), MYCN (PMID:33602789), and PHF20-mediated ubiquitin degradation (PMID:42215448). The MLL-GAS7 fusion transforms hematopoietic progenitors to cause mixed-lineage leukemia through a dimerization-dependent mechanism acting upstream of Hoxa7/Hoxa9 (PMID:12620410, PMID:15070702).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1998 Medium

    Established that GAS7 has a direct cellular role in neuronal morphogenesis rather than being a passive growth-arrest marker.

    Evidence Antisense inhibition in primary cerebellar cultures and overexpression in neuroblastoma cells

    PMID:9736752

    Open questions at the time
    • No molecular mechanism for how GAS7 promotes neurite outgrowth identified
    • No binding partners or cytoskeletal substrate defined
  2. 1999 Medium

    Resolved the gene architecture, defining tissue-specific isoforms with distinct N-termini that would later explain functional divergence.

    Evidence RNase protection, genomic BAC characterization, and cDNA cloning

    PMID:10552931

    Open questions at the time
    • Functional differences between isoforms not yet tested
    • Domain-level activities undefined
  3. 2002 High

    Identified the molecular basis of GAS7's morphogenic activity by showing direct F-actin binding and actin assembly/crosslinking driving membrane outgrowth.

    Evidence F-actin affinity chromatography, purified protein binding assay, cytochalasin D, EM, and domain-deletion overexpression

    PMID:11795944

    Open questions at the time
    • Did not connect actin activity to a defined nucleation machinery
    • Membrane-shaping role of F-BAR domain not yet established
  4. 2003 Medium

    Placed GAS7 within NGF-induced neuronal differentiation as an early intermediary, linking external trophic signaling to morphological change.

    Evidence Overexpression and antisense knockdown in PC12 cells with NGF stimulation

    PMID:14515354

    Open questions at the time
    • Upstream signaling connecting NGF to GAS7 not mapped
    • No effector identified downstream of GAS7
  5. 2003 Medium

    Demonstrated that GAS7 contributes oncogenic potential as an MLL fusion partner, transforming hematopoietic progenitors via dimerization.

    Evidence Retroviral transduction/transplantation in mice and colony-forming assays

    PMID:12620410

    Open questions at the time
    • Role of native GAS7 sequence versus dimerization motif not dissected
    • Relationship to normal GAS7 cytoskeletal function unclear
  6. 2004 Medium

    Positioned Hoxa7/Hoxa9 as downstream effectors of MLL-GAS7 leukemogenesis through genetic epistasis.

    Evidence Retroviral transduction/transplantation in Hoxa7/Hoxa9 knockout mice

    PMID:15070702

    Open questions at the time
    • Hox loss only modulated latency/penetrance, not abolishing transformation
    • Additional downstream targets not defined
  7. 2005 Medium

    Linked specific GAS7 domains to distinct protrusion morphologies, indicating modular control of cytoskeletal output.

    Evidence Isoform-specific construct transfection in Neuro-2a and SH-SY5Y cells

    PMID:15948147

    Open questions at the time
    • Molecular partners of WW versus FCH domains not identified here
    • Mechanism converting domain identity to filopodia/lamellipodia unresolved
  8. 2008 Medium

    Extended GAS7 function to mesenchymal lineage commitment, placing Gas7b downstream of ERK1/2 and SOX9 in chondrogenesis.

    Evidence Antisense/siRNA knockdown, ERK inhibitor PD98059, and aggregate chondrogenesis assays in human MSCs

    PMID:18455446

    Open questions at the time
    • Direct GAS7 effectors in chondrocytes not identified
    • Cytoskeletal mechanism in this context not tested
  9. 2009 High

    Revealed a second cytoskeletal activity—stabilization of tubulin sheet intermediates—broadening GAS7 from an actin to a dual cytoskeletal regulator.

    Evidence In vitro microtubule polymerization with purified Gas7, dark-field and electron microscopy

    PMID:19580814

    Open questions at the time
    • Domain responsible for tubulin binding not mapped
    • In vivo relevance of microtubule activity not established
  10. 2010 High

    Defined the actin-nucleation mechanism by showing GAS7 binds N-WASP via WW-Pro and recruits Arp2/3 independently of Cdc42.

    Evidence Reciprocal Co-IP, domain mutants, Arp2/3 recruitment, Cdc42 dominant-negative, and siRNA in hippocampal neurons

    PMID:20150425

    Open questions at the time
    • How GAS7 activates N-WASP biochemically not resolved
    • Spatial trigger for the interaction in neurons not defined
  11. 2012 Medium

    Provided organismal validation that GAS7 is required for motor neuron maintenance and neuromuscular function.

    Evidence Gas7-deficient mouse motor testing, histomorphometry, and NMJ analysis

    PMID:22662195

    Open questions at the time
    • Cell-autonomous versus systemic basis of motor defect unclear
    • Molecular pathway linking GAS7 loss to neuron loss not defined
  12. 2013 Medium

    Showed GAS7 drives osteoblast differentiation upstream of Runx2, extending its lineage-specification role.

    Evidence shRNA knockdown and overexpression with Runx2 reporter and mineralization assays in MSCs

    PMID:23840221

    Open questions at the time
    • Mechanism connecting cytoskeletal GAS7 to Runx2 transcription unknown
    • Direct molecular intermediates not identified
  13. 2018 Medium

    Established GAS7 as a p53-regulated metastasis suppressor acting through CYFIP1/WAVE2 to restrain Rac1-driven actin and integrin signaling.

    Evidence Transcriptional analysis of p53 regulation, Co-IP with CYFIP1/WAVE2, Rac1 interaction and actin polymerization assays in breast cancer

    PMID:29706651

    Open questions at the time
    • Structural basis for blocking CYFIP1–Rac1 not defined
    • Reconciliation with GAS7's pro-actin activities elsewhere unresolved
  14. 2019 High

    Defined the membrane-shaping mechanism: F-BAR sheet-like assembly on flat membranes via hydrophilic loops drives macrophage phagocytic cup formation.

    Evidence Super-resolution and cryo-EM on liposomes, hydrophilic-loop mutagenesis, and phagocytosis assays

    PMID:31628328

    Open questions at the time
    • How sheet assembly coordinates with actin machinery at the cup not fully mapped
    • Regulation of loop-mediated membrane binding unknown
  15. 2019 High

    Structurally characterized the GAS7 SH3 domain, revealing a non-canonical RT-loop ligand-binding mode distinct from typical SH3 pockets.

    Evidence Solution NMR structure with proline-rich and phage-display peptide titrations

    PMID:31296381

    Open questions at the time
    • Physiological SH3 ligands not identified
    • Functional role of the SH3 domain in cells untested
  16. 2020 Medium

    Uncovered a non-cytoskeletal role: GAS7 controls mitochondrial morphology through the PINK1/Drp-1/Mfn-2 axis in neurons.

    Evidence Gas7-knockout mouse with fractionation, phospho-protein Western blots, and ectopic rescue in null neurons

    PMID:32161906

    Open questions at the time
    • Whether GAS7 acts directly on mitochondrial machinery or indirectly unknown
    • Link between cytoskeletal and mitochondrial functions unresolved
  17. 2021 Medium

    Showed GAS7 suppresses metastasis in MYCN-driven neuroblastoma by maintaining cell-cell contact, and is repressed by MYCN.

    Evidence Zebrafish and mammalian GAS7-deficient neuroblastoma models with expression profiling and in vivo metastasis assays

    PMID:33602789

    Open questions at the time
    • Direct cell-contact genes mediating the effect not pinpointed
    • Mechanism of MYCN repression of GAS7 not defined
  18. 2023 Medium

    Identified GAS7 as an activity-dependent dendritic spine initiation factor requiring PI3K signaling and an intact F-BAR domain.

    Evidence Bicuculline activation of hippocampal slices, live imaging, PI3K inhibition, F-BAR mutants, and spine density quantification

    PMID:36963834

    Open questions at the time
    • How PI3K triggers GAS7 clustering biochemically not defined
    • Link between spine initiation and synaptic function not measured
  19. 2023 Low

    Reported GAS7 as a tumor suppressor in HCC acting via PI3K/Akt inhibition and repressed by Sp1.

    Evidence Functional proliferation/migration/apoptosis/autophagy assays and Sp1 analysis in HCC cells

    PMID:37769891

    Open questions at the time
    • PI3K/Akt mechanism not validated by reconstitution or structure
    • Direct versus indirect effect of GAS7 on the pathway unresolved
  20. 2026 Medium

    Defined post-translational control of GAS7 by PHF20-mediated ubiquitin degradation, linking GAS7 stability to nuclear F-actin and DNA damage repair.

    Evidence Co-IP, ubiquitination assay, PHF20 knockdown, nuclear F-actin imaging, DNA damage assay, and xenografts in cutaneous SCC

    PMID:42215448

    Open questions at the time
    • E3 ligase machinery directing GAS7 ubiquitination not identified
    • Mechanism by which nuclear GAS7 F-actin impairs repair unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How GAS7's distinct activities—actin assembly, microtubule stabilization, F-BAR membrane shaping, mitochondrial control, and nuclear F-actin—are integrated and switched in a context-dependent manner remains unresolved.
  • No unifying model linking cytoplasmic cytoskeletal and nuclear/mitochondrial roles
  • Domain-level determinants of context selection not mapped
  • Regulatory switches controlling pro- versus anti-actin behavior unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0060090 molecular adaptor activity 2 GO:0008289 lipid binding 1
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2 GO:0005739 mitochondrion 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 1
Partners
ACTR2/ACTR3 (ARP2/3)CYFIP1PHF20TUBBWASLWAVE2
Complex memberships
WAVE2 complex (CYFIP1/WAVE2)

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 GAS7 inhibition in terminally differentiating cerebellar cultures impedes neurite outgrowth from maturing Purkinje cells, and GAS7 overexpression in undifferentiated neuroblastoma cells promotes neurite-like outgrowth, establishing a direct role for GAS7 in neuronal morphological differentiation. In situ hybridization, immunocytochemistry, antisense inhibition in primary cerebellar cultures, overexpression in neuroblastoma cells Proceedings of the National Academy of Sciences of the United States of America Medium 9736752
1999 The Gas7 gene encodes two protein isoforms (Gas7 and Gas7-cb) by alternative splicing from distinct 5' exons; Gas7 is predominant in cerebrum and growth-arrested fibroblasts, while Gas7-cb is predominant in cerebellum, with unique N-terminal sequences. RNase protection assay, Western blot, genomic BAC characterization, cDNA cloning Genomics Medium 10552931
2002 GAS7 directly binds F-actin via its C-terminal domain, localizes near the plasma membrane in membrane ruffles via its C-terminal domain, promotes actin assembly and crosslinking of actin filaments, and induces membrane outgrowth requiring actin polymerization. F-actin affinity chromatography, purified His-Gas7 direct binding assay, cytochalasin D treatment, electron microscopy, ectopic overexpression with domain deletion mutants Experimental cell research High 11795944
2003 MLL-GAS7 fusion protein transforms multipotent hematopoietic progenitors and impairs their differentiation while enhancing in vitro growth, and induces mixed lineage leukemias in mice, acting through a dimerization-dependent mechanism. Retroviral transduction/transplantation assay in mice, in vitro colony-forming assays, immunophenotyping Cancer cell Medium 12620410
2003 GAS7 overexpression in PC12 cells induces expanded cell morphology and spike-like processes resembling early neurite formation; endogenous rat Gas7 is transiently elevated prior to NGF-promoted neurite outgrowth; antisense inhibition of Gas7 reduces NGF-promoted neurite outgrowths, establishing Gas7 as an early-stage intermediary in NGF-induced neuronal differentiation. Overexpression in PC12 cells, antisense oligonucleotide knockdown, NGF stimulation assay, RT-PCR Journal of neuroscience research Medium 14515354
2003 Hoxa7 and Hoxa9 contribute to MLL-GAS7-mediated leukemogenesis as downstream targets; Hoxa7/9 deficiency does not abolish transformation by MLL-GAS7 but increases disease latency and reduces penetrance, placing these Hox genes downstream of MLL-GAS7 in the leukemogenic pathway. Retroviral transduction/transplantation in Hoxa7- and Hoxa9-knockout mice, in vitro colony-forming assays, epistasis analysis Blood Medium 15070702
2005 Human GAS7 isoforms hGas7-a (FCH domain only) and hGas7-b (WW + FCH domains) differentially induce neurite-like processes: hGas7-a preferentially elicits lamellipodia, while hGas7-b elicits filopodia, implicating the WW domain in filopodia and the FCH domain in lamellipodia formation. Transfection of Neuro-2a and SH-SY5Y cells with isoform-specific constructs, quantitative PCR, protein expression analysis Journal of neuroscience research Medium 15948147
2008 GAS7b expression is transiently upregulated during chondrogenic differentiation of human MSCs downstream of ERK1/2 and SOX9 signaling; antisense inhibition of hGas7b impairs chondrogenesis, but Gas7b inhibition does not affect the p-ERK/SOX9 pathway, placing Gas7b downstream of ERK1/2 and SOX9. Antisense oligonucleotides, siRNA knockdown of SOX9, ERK inhibitor PD98059, aggregate culture chondrogenesis assay, Western blot, RT-PCR Osteoarthritis and cartilage Medium 18455446
2009 Gas7 stabilizes tubulin sheet intermediates during microtubule polymerization, promoting microtubule elongation without catastrophe; in the absence of Gas7, sheet-like structures were rarely observed and were fragile, demonstrating that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates. Dark-field microscopy real-time observation, electron microscopy, in vitro microtubule polymerization assay with and without Gas7 Journal of molecular biology High 19580814
2010 Gas7 co-localizes and physically interacts with N-WASP via WW-Pro domain interaction (not SH3-Pro) in growth cones of hippocampal neurons and recruits the Arp2/3 complex in a Cdc42-independent manner to promote membrane protrusions and neurite outgrowth. Co-immunoprecipitation, co-localization in Neuro-2a cells and hippocampal neurons, domain mutant analysis, Arp2/3 recruitment assay, Cdc42 dominant-negative experiment, siRNA knockdown The Journal of biological chemistry High 20150425
2012 Gas7-deficient mice show age-dependent motor activity defects associated with decreased spinal motor neuron numbers, reduced muscle strength, altered muscle fiber composition (fewer fast fibers in soleus), and reduced nerve terminal sprouting at neuromuscular junctions. Gas7-deficient mouse genetic model, motor function testing, histomorphometry, MHC I/II immunostaining, NMJ analysis PloS one Medium 22662195
2013 Gas7 knockdown using shRNA decreases Runx2 expression and its target genes (alkaline phosphatase, type I collagen, osteocalcin, osteopontin) and reduces mineralization; ectopic Gas7 expression induces Runx2-dependent transcriptional activity and osteoblast differentiation, establishing Gas7 as a regulator of osteogenesis upstream of Runx2. shRNA knockdown, ectopic overexpression, Runx2 transcriptional reporter assay, gene expression analysis, mineralization assay in MSC cultures Stem cells international Medium 23840221
2018 p53 directly regulates GAS7 gene expression; GAS7 associates with CYFIP1 and the WAVE2 complex to suppress breast cancer metastasis by blocking CYFIP1–Rac1 interaction, actin polymerization, and β1-integrin/FAK/Src signaling. ChIP/transcriptional analysis establishing p53 regulation of GAS7, co-immunoprecipitation of GAS7 with CYFIP1/WAVE2, Rac1 interaction assay, actin polymerization assay, signaling pathway analysis by Western blot Oncogene Medium 29706651
2019 The GAS7 F-BAR domain forms two-dimensional sheet-like assemblies on flat membranes through unique hydrophilic loops; this assembly is required for phagocytic cup formation in macrophages, and mutations of the hydrophilic loops abolish both membrane localization of GAS7 and phagocytosis. Super-resolution microscopy, cryo-EM/electron microscopy of GAS7 on liposomes, site-directed mutagenesis of hydrophilic loops, phagocytosis assay in macrophages, membrane localization assay Nature communications High 31628328
2019 The hGas7c SH3 domain adopts a typical β-barrel fold but exhibits a non-canonical ligand-binding mode, with chemical shift perturbations localized to the RT-loop rather than the canonical hydrophobic pockets, indicating distinctive ligand-binding specificity. Solution NMR structure determination, NMR titration with proline-rich peptide P41 and phage-display-selected peptides Biochemical and biophysical research communications High 31296381
2020 Gas7 localizes to mitochondria in neurons; Gas7 knockout leads to mitochondrial elongation and perinuclear clustering, increased mitochondrial fusion proteins, increased PKA-dependent phosphorylation of Drp-1, and reduced PINK1 expression and PINK1-mediated phosphorylation of Mfn-2, Parkin, and ubiquitin; ectopic Gas7 expression restores normal mitochondrial morphology and PINK1 levels. Gas7-knockout mouse, subcellular fractionation, immunofluorescence colocalization, Western blot for fusion/fission proteins and phospho-targets, ectopic Gas7 rescue in null neurons FASEB bioAdvances Medium 32161906
2021 GAS7 deficiency accelerates metastasis in MYCN-driven neuroblastoma by downregulating genes involved in cell-cell interaction and disrupting contact among tumor cells, and is associated with increased MYCN protein levels; GAS7 expression is suppressed by MYCN amplification. Zebrafish and mammalian GAS7-deficient neuroblastoma models with MYCN overexpression/amplification, expression profiling, ultrastructural analysis, in vivo metastasis assay Cancer research Medium 33602789
2023 Gas7 acts as a novel dendritic spine initiation factor; upon neuronal activation, Gas7 clusters at spine initiation hotspots in a PI3K-dependent manner requiring an intact F-BAR domain, recruits N-WASP and actin via Arp2/3 complex, and promotes new dendritic spine formation; Gas7 overexpression increases and knockdown decreases spine density in hippocampal neurons. Bicuculline activation of organotypic hippocampal slices, live imaging, PI3K inhibitor experiments, F-BAR domain mutants, N-WASP and actin colocalization, Arp2/3 inhibition, gain- and loss-of-function spine density quantification eNeuro Medium 36963834
2023 GAS7 inhibits HCC cell proliferation and migration, induces cell cycle arrest, apoptosis, and autophagy, and enhances oxaliplatin sensitivity by inhibiting the PI3K/Akt signaling pathway; transcription factor Sp1 is responsible for inhibiting Gas7 expression in HCC. Functional cell assays (proliferation, migration, apoptosis, autophagy), Western blot for PI3K/Akt pathway, Sp1 transcription factor analysis, oxaliplatin sensitivity assay Cellular signalling Low 37769891
2026 PHF20 interacts with GAS7 and promotes its ubiquitin-mediated degradation; loss of PHF20 stabilizes GAS7, which is associated with increased nuclear F-actin assembly and impaired DNA damage repair, sensitizing cutaneous squamous cell carcinoma cells to chemotherapy. Co-immunoprecipitation, ubiquitination assay, PHF20 knockdown and GAS7 stabilization measurement, nuclear F-actin imaging, DNA damage assay, in vivo tumor xenograft Cell death & disease Medium 42215448

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer cell 160 12620410
2003 Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood 133 15070702
2000 Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors. Proceedings of the National Academy of Sciences of the United States of America 85 10706619
1998 gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formation. Proceedings of the National Academy of Sciences of the United States of America 85 9736752
2002 Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. Experimental cell research 59 11795944
2010 Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons. The Journal of biological chemistry 48 20150425
2018 Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway. Oncogene 41 29706651
2017 MiR-181a contributes gefitinib resistance in non-small cell lung cancer cells by targeting GAS7. Biochemical and biophysical research communications 41 29269300
2019 Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Nature communications 30 31628328
2008 Involvement of Gas7 along the ERK1/2 MAP kinase and SOX9 pathway in chondrogenesis of human marrow-derived mesenchymal stem cells. Osteoarthritis and cartilage 30 18455446
2020 miR-362-5p promotes cell proliferation and cell cycle progression by targeting GAS7 in acute myeloid leukemia. Human cell 25 31925702
2020 Dicalcium silicate microparticles modulate the differential expression of circRNAs and mRNAs in BMSCs and promote osteogenesis via circ_1983-miR-6931-Gas7 interaction. Biomaterials science 22 32463418
2005 Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. Journal of neuroscience research 22 15948147
2003 Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. Journal of neuroscience research 21 14515354
2021 GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. Cancer research 18 33602789
1999 The Gas7 gene encodes two protein isoforms differentially expressed within the brain. Genomics 18 10552931
2005 Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice. Stem cells and development 17 16433621
2013 Gas7 is required for mesenchymal stem cell-derived bone development. Stem cells international 15 23840221
2012 Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging. PloS one 15 22662195
2009 Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7. Journal of molecular biology 15 19580814
2005 The gas7 protein potentiates NGF-mediated differentiation of PC12 cells. Brain research 14 15725398
2023 Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. Epigenetics 11 36908025
2020 Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons. FASEB bioAdvances 11 32161906
2005 Identification of rat Gas7 isoforms differentially expressed in brain and regulated following kainate-induced neuronal injury. Journal of neuroscience research 11 15657892
2024 Exosomal miR-4516 derived from ovarian cancer stem cells enhanced cisplatin tolerance in ovarian cancer by inhibiting GAS7. Gene 10 38955306
2023 Gas7 Is a Novel Dendritic Spine Initiation Factor. eNeuro 10 36963834
2017 Polymorphism rs11656696 in GAS7 Is Not Associated with Primary Open Angle Glaucoma in a Saudi Cohort. Genetic testing and molecular biomarkers 10 29022762
2022 Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population. Molecular vision 7 35400990
2012 Identification and functional characterization of zebrafish Gas7 gene in early development. Journal of neuroscience research 7 23086717
2023 Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway. Cellular signalling 6 37769891
2019 Association of polymorphism rs11656696 in GAS7 with primary open-Angle Glaucoma in a Chinese Population. Ophthalmic genetics 6 31269845
2018 Neuronal localization of GAS7 within human brain tissue: Implications for schizophrenia research. Neurology international 6 30687465
2021 Loss of Gas7 Is a Key Metastatic Switch in Neuroblastoma. Cancer research 4 34087781
2021 Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression. Journal of integrative bioinformatics 4 34914337
2006 Expression of GAS7 in childhood CNS tumors. Pediatric blood & cancer 4 16078223
2024 Adipose stem cell-derived exosomes promote wound healing by regulating the let-7i-5p/GAS7 axis. Journal of cosmetic dermatology 3 38429909
2019 Immunolocalization of Gas7 in the Subgranular Zone of Mice Hippocampus. Prague medical report 3 31935346
2006 MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia. Haematologica 3 16956839
2023 Electroacupuncture Increases the Expression of Gas7 and NGF in the Prefrontal Cortex of Male Rats with Focal Cerebral Ischemia. Journal of integrative neuroscience 2 37258449
2022 Cannabis, Intraocular Pressure, and the Growth Arrest-Specific 7 (GAS7) Gene: A Retrospective Analysis. Cureus 2 35411287
2019 [Effect of electroacupuncture on expressions of Gas7 and NGF in arcular nucleus of rats with focal cerebral ischemia]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 1 31724358
2026 Role of Macrophage-Related Genes GAS7 and ZEB2 in Acute Myocardial Infarction Pathogenesis. Human mutation 0 42136960
2026 PHF20 stabilizes the GAS7-F-actin axis to drive DNA damage repair and chemoresistance in cutaneous squamous cell carcinoma. Cell death & disease 0 42215448
2025 A novel long non-coding RNA, Lnc-GAS7, modulates myosin heavy chain isoform switching via AMPK signaling in ovine muscle. International journal of biological macromolecules 0 41086893
2024 Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China. Experimental biology and medicine (Maywood, N.J.) 0 38240248
2019 Solution NMR structure and ligand identification of human Gas7 SH3 domain reveal a typical SH3 fold but a non-canonical ligand-binding mode. Biochemical and biophysical research communications 0 31296381

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