Affinage

GABPB1

GA-binding protein subunit beta-1 · UniProt Q06547

Round 2 corrected
Length
395 aa
Mass
42.5 kDa
Annotated
2026-04-28
54 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GABPB1 encodes the transcriptional activation subunit of the heteromeric ETS-family transcription factor GA-binding protein (GABP/NRF-2), functioning as an obligate partner of the DNA-binding GABPα subunit to regulate nuclear-encoded mitochondrial genes, cell-cycle control targets, and telomerase. Its ankyrin-repeat domain forms an extensive protein–protein interface with the GABPα ETS domain (PMID:9461436), while a C-terminal coiled-coil mediates β-subunit homodimerization and tetramerization (PMID:7958862); transcriptional activation depends on tandem hydrophobic clusters within a conserved ~40-residue activation domain (PMID:8816484). GABPB1 activates respiratory chain gene promoters through an HCF-1-bridged complex with the coactivator PRC (PMID:18343819), directly drives YAP transcription linking it to Hippo-pathway output (PMID:23684612), and—via its tetramer-forming long isoform GABPB1L—selectively activates the mutant TERT promoter in glioblastoma, where its disruption causes telomere shortening and tumor regression (PMID:30205050). GABPB1 protein stability is regulated by BAIAP2L2-dependent protection from ubiquitin-mediated degradation and by antisense lncRNA GABPB1-AS1-mediated translational repression (PMID:39496939, PMID:31700067), and Gabpb1 knockout causes preimplantation lethality in mice (PMID:37640449).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1993 High

    Identification of GABPB1 as the non-DNA-binding subunit of GABP/NRF-2 resolved how an ETS-family factor activates nuclear-encoded mitochondrial respiratory genes, establishing the obligate α/β heterodimer architecture.

    Evidence Protein purification from HeLa cells with peptide sequencing, promoter binding and transfection assays; independent cDNA cloning showing ankyrin repeats and heterodimerization requirement

    PMID:8383622 PMID:8441384

    Open questions at the time
    • No structural detail on how ankyrin repeats contact GABPα
    • Activation domain not yet mapped
  2. 1995 High

    Characterization of multiple GABPB splice isoforms and mapping of a conserved hydrophobic activation domain defined the modular architecture through which GABPB1 transduces transcriptional activation, while identification of the coiled-coil dimerization motif explained how β subunits oligomerize.

    Evidence cDNA cloning, GAL4 fusion assays, deletion/alanine mutagenesis, circular dichroism spectroscopy of coiled-coil peptides

    PMID:7799916 PMID:7958862 PMID:8816484

    Open questions at the time
    • No high-resolution structure of the coiled-coil tetramer
    • Functional distinction between β1 and β2 isoforms unclear
  3. 1998 High

    The 2.15 Å crystal structure of the GABPα ETS domain–GABPβ ankyrin repeat complex on DNA revealed the molecular basis for obligate heterodimerization and indirect DNA recognition by the β subunit.

    Evidence X-ray crystallography at 2.15 Å resolution

    PMID:9461436

    Open questions at the time
    • Structure lacks the activation domain and coiled-coil tetramerization region
    • No structure of the full-length tetramer on tandem ETS sites
  4. 2000 High

    Discovery that HCF-1 (C1) directly binds GABPB1 and functions as a coactivator established the first known coactivator partnership for GABP, later shown to bridge additional coactivators such as PRC to NRF-2-dependent promoters.

    Evidence Co-immunoprecipitation, mutagenesis linking interaction to transactivation, in vitro binding, ChIP, shRNA knockdown of PRC

    PMID:10675337 PMID:18343819

    Open questions at the time
    • Stoichiometry of the PRC–HCF-1–GABP complex on chromatin unknown
    • Whether other coactivators use the same HCF-1 bridge is untested
  5. 2013 High

    Demonstration that GABP directly binds and activates the YAP promoter linked GABPB1 to Hippo pathway regulation and cell-cycle control, broadening its role beyond mitochondrial biogenesis.

    Evidence ChIP, shRNA knockdown, YAP reconstitution rescue, cell-cycle analysis, in vivo mouse liver injury model

    PMID:23684612

    Open questions at the time
    • Whether GABP regulation of YAP is tissue-specific is unexplored
    • Mechanism by which oxidative stress inhibits GABP DNA-binding activity not fully resolved
  6. 2018 High

    The finding that the tetramer-forming long isoform GABPB1L is selectively required for mutant TERT promoter activation in glioblastoma provided an isoform-specific oncogenic mechanism and a potential therapeutic vulnerability.

    Evidence CRISPR disruption of GABPB1L, isoform-specific rescue, telomere length assays, orthotopic xenograft models

    PMID:30205050

    Open questions at the time
    • Whether GABPB1L selectivity for mutant TERT extends to all TERT-promoter-mutant cancer types is incompletely tested
    • Structural basis for why the tetramer, but not the dimer, activates the mutant promoter is unknown
  7. 2019 Medium

    Identification of lncRNA GABPB1-AS1 as a translational repressor of GABPB1 revealed a post-transcriptional regulatory layer linking GABPB1 levels to antioxidant defense (PRDX5 expression) and ferroptosis susceptibility.

    Evidence Erastin treatment, antisense lncRNA overexpression/knockdown, Western blot showing protein but not mRNA change, PRDX5 reporter assay in HepG2 cells

    PMID:31700067

    Open questions at the time
    • Translational repression mechanism (ribosome stalling vs. mRNA sequestration) is undefined
    • Generalizability beyond HepG2 cells not established
  8. 2022 Medium

    Studies in thyroid cancer and GBM revealed that GABPB1 silencing not only reduces TERT expression but also reshapes glycolytic/redox metabolism and paradoxically enhances invasion in certain contexts, revealing context-dependent roles.

    Evidence shRNA knockdown, 1H/13C-MRS metabolomics, invasion assays, zebrafish xenograft, methylation-specific PCR

    PMID:35326537 PMID:35460557

    Open questions at the time
    • Whether metabolic changes are direct transcriptional targets or secondary to TERT loss is unresolved
    • Paradoxical tumor-suppressive effect in thyroid cancer awaits independent replication
  9. 2023 Medium

    Gabpb1 knockout causes preimplantation embryonic lethality with apoptosis in mice, and mRNA supplementation rescues cloned embryo development, establishing GABPB1 as essential for early mammalian development.

    Evidence CRISPR/Cas9 knockout, mRNA rescue, H3K9me3 ChIP in nuclear transfer embryos

    PMID:37640449

    Open questions at the time
    • Specific GABPB1 target genes required for preimplantation survival are not identified
    • Whether the essential role maps to mitochondrial gene regulation or another program is unknown
  10. 2024 Medium

    BAIAP2L2 was shown to stabilize GABPB1 by blocking ubiquitin-mediated degradation and promoting nuclear translocation, identifying the first post-translational stabilization pathway for GABPB1 and linking it to drug resistance in HCC.

    Evidence Co-immunoprecipitation, ubiquitination assay, nuclear/cytoplasmic fractionation, ChIP for NFκB1 binding to BAIAP2L2 promoter

    PMID:39496939

    Open questions at the time
    • The E3 ubiquitin ligase targeting GABPB1 for degradation is unidentified
    • Whether BAIAP2L2-mediated stabilization operates outside HCC is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include the structural basis for GABPB1L tetramer selectivity at mutant TERT promoters, the identity of the E3 ligase governing GABPB1 turnover, and the full set of direct transcriptional targets that account for GABPB1's essential developmental role.
  • No full-length tetramer structure exists
  • E3 ligase for GABPB1 ubiquitination unknown
  • Genome-wide direct target catalog in developmental context is lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0060090 molecular adaptor activity 3
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1643685 Disease 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-162582 Signal Transduction 1
Partners
BAIAP2L2GABPAHCF1HOMER3PPRC1
Complex memberships
GABP (NRF-2) heterodimer/tetramerPRC–HCF-1–NRF-2 coactivator complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 GABPB1 (as part of NRF-2/GABP) was identified as a multi-subunit transcription factor whose beta subunit (GABPB1) forms heteromeric complexes with the DNA-binding alpha subunit and activates nuclear genes encoding mitochondrial respiratory chain components, including cytochrome c oxidase subunits IV and Vb. NRF-2 was shown to be identical to GABP, thus assigning a cellular role in respiratory gene expression to an ETS domain activator previously known only for viral promoter activation. Protein purification from HeLa cells, peptide sequencing, promoter binding assays, transfection assays Genes & development High 8383622
1993 GABPB1 (E4TF1-53/E4TF1-47) was cloned and shown to contain four tandem ankyrin/notch repeats, lacks intrinsic DNA-binding activity, and heterodimerizes with the ETS-domain-containing alpha subunit (E4TF1-60/GABPα) to form a functional transcription factor complex; heterodimerization is essential for transcriptional activity. Protein purification, partial amino acid sequencing, cDNA cloning, gel retardation assay, recombinant protein expression in E. coli Molecular and cellular biology High 8441384
1995 Four structurally distinct beta/gamma subunits of NRF-2 (including GABPB1/beta1 and beta2, and gamma1/gamma2 variants with a 12-amino-acid insertion) were cloned and shown to share a conserved ~70 amino acid transcriptional activation domain containing tandem glutamine-containing hydrophobic clusters. All four subunits associate with GABPα and support high-affinity binding to tandem NRF-2 sites, and all activate transcription equally when fused to a GAL4 DNA-binding domain. cDNA cloning, overexpression, co-immunoprecipitation, GAL4 fusion transcription assays, deletion mapping, PCR, RNase protection Molecular and cellular biology High 7799916
1994 The mouse genome encodes two highly related GABP beta polypeptides (GABPβ1 and GABPβ2) whose carboxy-terminal regions mediate dimerization via a coiled-coil (leucine zipper-like) mechanism. GABPβ1 and GABPβ2 can heterodimerize through this domain. The three GABP subunit genes map to three unlinked chromosomal loci yet show concordant expression patterns. Genomic and cDNA cloning, circular dichroism spectroscopy of synthetic peptides, leucine zipper swap experiment, chromosomal mapping Genes & development High 7958862
1996 The transcriptional activation domain of NRF-2 (GABPB1) was mapped by deletion and alanine substitution mutagenesis to tandemly arranged clusters of hydrophobic amino acids (containing glutamines) within a ~40 residue region. Glutamine residues themselves are not required for activation; rather, the surrounding hydrophobic residues are essential. This mechanism is shared with NRF-1. Deletion mutagenesis, alanine substitution mutagenesis, transfection-based transcription assays Molecular and cellular biology High 8816484
1998 The crystal structure of GABPα/β (ETS domain – ankyrin repeat heterodimer) bound to DNA was determined at 2.15 Å resolution. The structure reveals: (1) the ankyrin repeats of GABPβ form an extensive protein-protein interface with both the ETS domain and a C-terminal extension of GABPα; (2) GABPα binds DNA through the GGA core recognition motif; (3) GABPβ is recruited by GABPα using both the ETS domain and a C-terminal extension of GABPα. X-ray crystallography at 2.15 Å resolution Science High 9461436
2000 The cellular coactivator C1/HCF directly interacts with GABPβ (GABPB1), functioning as a novel coactivator of GABP-mediated transcription. Mutations in GABPβ that reduce GABP transactivation potential also impair the C1-GABP interaction, indicating C1/HCF mediates GABP transcriptional activity. C1/HCF coordinates multi-protein enhancer assembly at HSV-1 IE gene promoters by interacting with GABP, Oct-1, and αTIF. Co-immunoprecipitation, mutagenesis, transcription assays, HSV-1 IE gene enhancer functional studies The EMBO journal High 10675337
2008 PRC (PGC-1-related coactivator) associates with NRF-2/GABP in vivo via an HCF-1 intermediary. Neither PRC nor PGC-1α binds NRF-2β (GABPB1) directly; instead HCF-1 bridges the complex. Both PRC and NRF-2β bind HCF-1 in vitro. The PRC–HCF-1–NRF-2 complex occupies NRF-2-dependent promoters (TFB1M, TFB2M) in vivo, and PRC knockdown reduces TFB2M mRNA and mitochondrial transcripts and cytochrome oxidase activity. Co-immunoprecipitation, in vitro binding assays, chromatin immunoprecipitation, shRNA knockdown, enzyme activity assays The Journal of biological chemistry High 18343819
2013 GABP (requiring GABPB1 as a functional partner) directly binds the YAP/Yap promoter and activates YAP transcription. Depletion of GABP downregulates YAP, causing G1/S cell-cycle arrest and increased cell death, both rescued by YAP reconstitution. GABP transcriptional activity is inhibited by oxidative stress (glutathione depletion), linking GABP to the Hippo pathway as an upstream activator of YAP. ChIP, shRNA knockdown, YAP reconstitution rescue, cell cycle analysis, promoter reporter assay, in vivo mouse liver injury model Cell reports High 23684612
2018 GABPB1L (the long isoform of GABPB1, β1L), which enables GABP tetramer formation, is selectively required for activating the mutant TERT promoter in glioblastoma cells harboring TERT promoter mutations. Genetic disruption of β1L silences TERT expression in a TERT promoter mutation-dependent manner, leading to telomere shortening and cell death exclusively in mutant cells, with no effect on normal cells. In vivo, β1L disruption reduces tumor burden and extends survival in orthotopic xenograft models. CRISPR-mediated gene disruption, shRNA knockdown, TERT expression analysis, telomere length assays, orthotopic xenograft in vivo model Cancer cell High 30205050
2022 GABPB1 knockdown in thyroid cancer cells harboring TERT promoter mutations diminishes TERT expression and telomerase activity but paradoxically increases invasive potential in vitro and metastatic potential in a zebrafish xenograft model, with altered EMT marker expression. GABPB1 promoter hypermethylation suppresses its expression in aggressive thyroid cancers, and DNA methylation inhibitors restore GABPB1 expression. This demonstrates that GABPB1 has dual roles: required for TERT/telomerase activation but also functioning as a tumor suppressor to limit thyroid cancer progression. shRNA knockdown, invasion assays, zebrafish xenograft model, methylation-specific PCR, DNA methylation inhibitor treatment, EMT marker analysis Cancers Medium 35326537
2022 GABPB1 silencing in TERT-promoter-mutant GBM cells reduces lactate, glutathione (GSH), and hyperpolarized [1-13C]lactate production as detected by 1H- and 13C-MRS. Mechanistically, GSH reduction is linked to reduced pentose phosphate pathway flux and glucose-6-phosphate dehydrogenase activity, and lactate reduction is associated with decreased glycolytic flux, NADH, and reduced expression/activity of GLUT1, monocarboxylate transporters, and lactate dehydrogenase A. 1H-MRS, hyperpolarized 13C-MRS, enzyme activity assays, shRNA knockdown, in vivo tumor models Neuro-oncology Medium 35460557
2023 HOMER3 and platelet-activating factor acetylhydrolase 1b catalytic subunit 3 cooperate to upregulate GABPB1 protein levels in NSCLC, which in turn controls mitochondrial inner membrane gene expression and mitochondrial function. Loss of HOMER3 reduces GABPB1 levels, leading to mitochondrial dysfunction and decreased proliferation and invasion of lung cancer cells in vitro and in vivo. shRNA knockdown, co-immunoprecipitation, in vitro and in vivo proliferation/invasion assays, mitochondrial function assays Cell death & disease Medium 38081871
2023 GABPB1 was identified as a developmentally essential gene in mice; CRISPR/Cas9 knockout of Gabpb1 results in early preimplantation developmental arrest associated with apoptosis. In nuclear transfer (cloned) embryos, Gabpb1 fails to be properly reactivated due to H3K9me3-mediated repression (partly through repressed Klf16 expression), and supplementation of Gabpb1 mRNA supports efficient preimplantation development of cloned embryos. CRISPR/Cas9 knockout, siRNA screening, mRNA supplementation rescue, H3K9me3 ChIP analysis, embryo development assays Life science alliance Medium 37640449
2019 Erastin upregulates the lncRNA GABPB1-AS1, which blocks translation of GABPB1 protein (without altering mRNA levels), leading to reduced PRDX5 (Peroxiredoxin-5) expression, suppressed antioxidant capacity, and ferroptotic cell death in HepG2 hepatocellular carcinoma cells. GABPB1 protein thus functions downstream of GABPB1-AS1 to maintain PRDX5 expression and cellular redox homeostasis. Erastin treatment, lncRNA overexpression/knockdown, Western blot (protein level without mRNA change), PRDX5 reporter assay, cell viability assay Scientific reports Medium 31700067
2024 BAIAP2L2 interacts with GABPB1 protein to inhibit its ubiquitin-mediated degradation and promote its nuclear translocation in hepatocellular carcinoma cells. NFκB1 stimulates BAIAP2L2 transcription by binding its promoter. Through stabilizing GABPB1 and promoting its nuclear entry, BAIAP2L2 reduces ROS levels and enhances HCC malignancy and lenvatinib resistance. Co-immunoprecipitation, ubiquitination assay, nuclear/cytoplasmic fractionation, promoter binding ChIP assay, shRNA knockdown, ROS measurement Cancer gene therapy Medium 39496939
2024 shRNA-mediated suppression of GABPB1 in NSCLC cell lines A549 and H1299 decreases cell growth, clone formation, and increases apoptosis rate, confirming a cancer-promoting role for GABPB1 in lung cancer cell proliferation and survival. shRNA knockdown, colony formation assay, CCK-8 cell viability, apoptosis assay Discover oncology Low 38466508

Source papers

Stage 0 corpus · 54 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 An empirical framework for binary interactome mapping. Nature methods 652 19060904
2008 Genome-scale RNAi screen for host factors required for HIV replication. Cell host & microbe 627 18976975
2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 610 16713569
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1998 The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Science (New York, N.Y.) 265 9461436
1993 Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Genes & development 262 8383622
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
2019 LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. Scientific reports 194 31700067
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2013 The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell reports 112 23684612
2018 Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer cell 107 30205050
1995 Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Molecular and cellular biology 100 7799916
2020 Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature metabolism 92 32694731
1993 cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. Molecular and cellular biology 92 8441384
2020 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell reports 79 32814053
1994 Molecular and genetic characterization of GABP beta. Genes & development 73 7958862
2000 The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. The EMBO journal 68 10675337
2008 PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression. The Journal of biological chemistry 66 18343819
1996 Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. Molecular and cellular biology 66 8816484
2022 Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery. Nature communications 65 35831314
2020 HPV16 E6 oncoprotein-induced upregulation of lncRNA GABPB1-AS1 facilitates cervical cancer progression by regulating miR-519e-5p/Notch2 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 32844486
2022 Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma. Neuro-oncology 17 35460557
2021 Long Non-Coding RNA GABPB1-AS1 Augments Malignancy of Glioma Cells by Sequestering MicroRNA-330 and Reinforcing the ZNF367/Cell Cycle Signaling Pathway. Neuropsychiatric disease and treatment 16 34276213
2023 HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism. Cell death & disease 15 38081871
2012 The GABPB1 gene A/G polymorphism in Polish rowers. Journal of human kinetics 9 23486860
2023 LncRNA GABPB1-IT1 inhibits the tumorigenesis of renal cancer via the miR-21/PTEN axis. Journal of biochemical and molecular toxicology 8 36756790
2023 LncRNA FTX Inhibits Ferroptosis of Hippocampal Neurons Displaying Epileptiform Discharges In vitro Through the miR-142-5p/GABPB1 Axis. Neuroscience 8 37121382
2022 Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features. Cancers 8 35326537
2022 GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/β-Catenin Pathway. Journal of oncology 8 35342417
2022 GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47. Oncology research 7 37304650
2023 Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos. Life science alliance 6 37640449
2023 Hyperpolarized δ-[1- 13C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma. Scientific reports 5 36997627
2019 Association of SNP rs7181866 in the nuclear respiratory factor-2 beta subunit encoding GABPB1 gene with obesity and type-2 diabetes mellitus in South Indian population. International journal of biological macromolecules 5 30904536
2024 GABPB1 plays a cancer-promoting role in non-small cell lung cancer. Discover oncology 3 38466508
2020 Association study of performance-related polymorphisms in Brazilian combat-sport athletes highlights variants in the GABPB1 gene. Physiological genomics 3 33346691
2024 LncRNA GABPB1-AS1 is a potential target for the diagnosis of prostate cancer. Nucleosides, nucleotides & nucleic acids 2 39004908
2024 BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance. Cancer gene therapy 2 39496939
2025 Isoflurane aggravates cognitive deficits in aged rats via lncRNA GABPB1-AS1/miR-361-3p-mediated NLRP3 inflammasome activation. Toxicology and applied pharmacology 1 40972828
2024 Silencing lncRNA GABPB1-AS1 alleviates cerebral ischemia reperfusion injury through the miR-641/NUCKS1 axis. American journal of translational research 1 39114718
2021 lncRNA GABPB1 intronic transcript 1 upregulates pigment epithelium-derived factor via miR-93 to suppress cell proliferation in hepatocellular carcinoma. Oncology letters 1 33664823
2025 Genetic biomarkers of skiers from the Oğlağo Tribe in Muş Province, Turkey: An analysis of ACTN3, VEGF-A, and GABPB1 polymorphisms. Medicine 0 40388723
2024 LncRNA GABPB1-IT1 Is Upregulated in Ischemia-Induced Acute Kidney Injury and Downregulates miR-204-5p to Promote Hypoxia-Induced Human Renal Proximal Tubular Epithelial Cell Apoptosis. Kidney & blood pressure research 0 38824919
2022 Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. Toxicology and industrial health 0 35343317