Affinage

PPRC1

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 · UniProt Q5VV67

Length
1664 aa
Mass
177.5 kDa
Annotated
2026-04-28
76 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PPRC1 is a growth-regulated transcriptional coactivator that functions as a critical regulator of mitochondrial biogenesis, respiratory chain gene expression, and cellular stress responses. Knockdown of PPRC1 severely impairs respiratory chain function, reduces expression of complexes I–IV, diminishes mitochondrial ATP production, and causes proliferation of abnormal mitochondria lacking organized cristae (PMID:19036724). PPRC1 protein stability is controlled post-translationally through an Akt–GSK-3β signaling axis: GSK-3 phosphorylation of C-terminal serine residues promotes PPRC1 degradation, while mitochondrial stress activates Akt to phospho-inactivate GSK-3β and stabilize PPRC1, acting in concert with c-MYC to reprogram gene expression during apoptosis and premature senescence (PMID:27789709, PMID:23364789). In vivo, heterozygous Pprc1 knockout mice exhibit elevated energy expenditure and resistance to diet-induced obesity, with haploinsufficiency causing downregulation of PGC-1α and PGC-1β in skeletal muscle, confirming a non-redundant role in systemic energy metabolism (PMID:25994039).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2008 High

    The foundational question of whether PPRC1 is required for mitochondrial function was resolved: PPRC1 loss of function causes comprehensive respiratory chain failure and mitochondrial structural disorganization, establishing it as an essential regulator of mitochondrial biogenesis.

    Evidence Lentiviral shRNA knockdown with two independent hairpins in U2OS cells, measuring respiratory enzyme activity, ATP production, gene expression by microarray, and mitochondrial ultrastructure by electron microscopy

    PMID:19036724

    Open questions at the time
    • No identification of specific transcription factor partners through which PPRC1 drives respiratory gene expression
    • In vivo requirement not yet tested
    • Mechanism of PPRC1 regulation itself unknown
  2. 2013 Medium

    PPRC1 was shown to be a stress-responsive gene activated during apoptosis and premature senescence through ROS-dependent signaling, revealing that its function extends beyond basal mitochondrial maintenance to cellular stress adaptation, with c-MYC coordinately induced alongside PPRC1.

    Evidence Pharmacological stress induction (menadione, SN-38, meclizine) with antioxidant rescue (NAC) and c-MYC siRNA in U2OS cells

    PMID:23364789

    Open questions at the time
    • Direct transcriptional mechanism linking ROS to PPRC1 promoter activation not defined
    • Whether c-MYC directly binds the PPRC1 promoter or acts indirectly not established
    • Single laboratory findings
  3. 2013 Medium

    PPRC1 was identified as a suppressor of NF-κB-mediated endothelial inflammation, broadening its functional scope beyond mitochondrial biogenesis to inflammatory signaling.

    Evidence PPRC1 overexpression in HUVECs with LPS stimulation, NF-κB reporter assays, VCAM-1/E-selectin expression, and monocyte adhesion assays

    PMID:23954632

    Open questions at the time
    • No endogenous loss-of-function experiment to confirm anti-inflammatory role
    • Mechanism by which PPRC1 inhibits NF-κB activity not defined
    • Limited to overexpression system in a single lab
  4. 2015 Medium

    In vivo genetic evidence confirmed PPRC1's non-redundant role in energy metabolism: heterozygous knockout mice showed elevated energy expenditure and resistance to diet-induced obesity, with tissue-specific haploinsufficiency effects on PGC-1 family members.

    Evidence Pprc1 heterozygous knockout mice on high-fat diet with metabolic phenotyping and gene expression profiling in skeletal muscle and adipose tissue

    PMID:25994039

    Open questions at the time
    • Complete knockout phenotype not reported (likely embryonic lethal but not characterized)
    • Tissue-specific conditional knockout not performed
    • Mechanism of compensatory PGC-1 family upregulation in adipose tissue unknown
  5. 2016 High

    The post-translational regulation of PPRC1 was elucidated: GSK-3 phosphorylates two C-terminal serine residues to destabilize PPRC1, while mitochondrial stress activates the Akt–GSK-3β axis to stabilize PPRC1 protein, with c-MYC acting upstream in this pathway.

    Evidence GSK-3 site mutagenesis, pharmacological epistasis with Akt (MK-2206) and GSK-3 (AZD2858) inhibitors, c-MYC siRNA, and protein half-life measurements after CCCP-induced mitochondrial uncoupling

    PMID:27789709

    Open questions at the time
    • The E3 ubiquitin ligase mediating GSK-3-dependent PPRC1 degradation not identified
    • Whether additional kinases regulate PPRC1 stability is unknown
    • Structural basis for GSK-3 recognition of PPRC1 not determined
  6. 2020 Medium

    An alternative pathway for PPRC1 induction was identified through PDE5 inhibition: sildenafil induces PPRC1 via cAMP–CREB signaling, independently of Akt3, and PPRC1 can functionally rescue mitochondrial defects caused by Akt3 depletion.

    Evidence Sildenafil treatment of Akt3-depleted endothelial cells with oxygen consumption, mtDNA, and VDAC assays; CREB reporter and cAMP pathway analysis

    PMID:33087445

    Open questions at the time
    • Direct CREB binding to PPRC1 promoter not demonstrated by ChIP
    • Whether PPRC1 fully substitutes for PGC-1α in vivo not tested
    • Single laboratory
  7. 2021 Low

    A heterozygous missense mutation in PPRC1 (p.Thr958Ile) was linked to familial premature ovarian failure, suggesting a role for PPRC1 in ovarian granulosa cell survival.

    Evidence Whole exome sequencing and Sanger validation in a single Chinese family; PPRC1 overexpression in COV434 granulosa cells with apoptosis assays

    PMID:33818872

    Open questions at the time
    • Single family pedigree without replication in independent cohorts
    • No demonstration that the Thr958Ile variant causes loss of function biochemically
    • Granulosa cell phenotype based on overexpression, not endogenous mutation modeling
  8. 2025 Medium

    Pharmacological downregulation of PPRC1 by eugenol in AML cells induced mitochondrial depolarization and apoptosis, supporting PPRC1 as a pro-survival factor that maintains mitochondrial integrity in leukemia.

    Evidence Eugenol treatment of AML cell lines and primary patient cells with PPRC1 mRNA/protein quantification, mitochondrial membrane potential assays, and apoptosis measurement

    PMID:39996733

    Open questions at the time
    • No direct PPRC1 loss-of-function rescue to confirm PPRC1 as the critical eugenol target
    • Whether PPRC1 dependence is specific to AML or general across cancers is unknown
    • Eugenol has pleiotropic effects; PPRC1 may be a secondary target

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the E3 ligase mediating GSK-3-dependent PPRC1 degradation, the direct transcription factor partners through which PPRC1 activates respiratory chain gene promoters, and whether complete PPRC1 loss is embryonic lethal.
  • No structural information for PPRC1 or its coactivator domains
  • Genome-wide direct target identification by ChIP-seq not performed
  • Conditional tissue-specific knockout models lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 3
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-162582 Signal Transduction 2 R-HSA-5357801 Programmed Cell Death 2
Partners
AKT1GSK3BMYC

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Stable shRNA-mediated knockdown of PRC (PPRC1) in U2OS cells caused severe inhibition of respiratory chain function, reduced expression of respiratory protein subunits from complexes I, II, III, and IV, markedly lower complex I and IV enzyme levels, diminished mitochondrial ATP production, and proliferation of abnormal mitochondria devoid of organized cristae, establishing PRC as required for mitochondrial respiratory function and integrity. Lentiviral shRNA knockdown (two independent shRNAs), respiratory enzyme assays, mitochondrial ATP production measurement, microarray gene expression analysis, electron microscopy of mitochondrial morphology The Journal of biological chemistry High 19036724
2013 PRC (PPRC1)-dependent stress program is activated during apoptosis and premature senescence; PRC and its target genes (IL1α, SPRR2D, SPRR2F) are rapidly induced by menadione (apoptosis via ROS) and by topoisomerase I inhibitor SN-38 (premature senescence). Antioxidant N-acetylcysteine blocked menadione-induced PRC induction, and c-MYC was coordinately induced with PRC under all stress conditions tested. Pharmacological induction (menadione, SN-38, meclizine), antioxidant rescue experiments, gene expression assays, senescence-associated β-galactosidase staining, siRNA knockdown of c-MYC The Journal of biological chemistry Medium 23364789
2016 PRC (PPRC1) and c-MYC act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress. GSK-3 phosphorylation of two serine residues in the PRC C-terminal domain reduces PRC steady-state expression; mutation of these GSK-3 sites markedly increased PRC protein levels. CCCP-induced mitochondrial uncoupling activated Akt, which phospho-inactivated GSK-3β, thereby stabilizing PRC post-translationally. c-MYC inhibition blocked PRC induction, and Akt inhibition blocked both c-MYC and PRC induction. GSK-3 site mutagenesis, pharmacological inhibitors (10058-F4, AZD2858, MK-2206), c-MYC siRNA silencing, protein half-life measurements, Akt inhibitor experiments The Journal of biological chemistry High 27789709
2020 PDE5 inhibition by sildenafil induces PRC (PPRC1) expression through a cAMP- and CREB-dependent mechanism, independently of Akt3. PRC induction by sildenafil rescued mitochondrial dysfunction (uncoupled oxygen consumption, mitochondrial DNA content, VDAC expression) caused by Akt3 depletion and promoted angiogenesis, demonstrating that PRC can functionally substitute for PGC-1α during mitochondrial stress. Akt3 siRNA depletion, sildenafil treatment, oxygen consumption assays, mitochondrial DNA quantification, VDAC protein expression, tube formation angiogenesis assays, cAMP pathway analysis, CREB reporter assays The Journal of biological chemistry Medium 33087445
2013 PRC (PPRC1) overexpression in HUVECs suppresses LPS-induced endothelial inflammation by inhibiting NF-κB transcriptional activity, reducing VCAM-1 and E-selectin expression, attenuating monocyte adhesion, and protecting mitochondrial metabolic function. Overexpression in HUVECs, NF-κB reporter assay, VCAM-1/E-selectin expression assays, monocyte adhesion assay, mitochondrial function measurement Biochemical and biophysical research communications Medium 23954632
2014 PRC (PPRC1) cooperates with STAT6 to induce M2 microglia polarization; PRC overexpression increased arginase-1 (Arg1), Fizz1 (Retnla), and Ym1 (Chi3l3) expression, while PRC silencing attenuated M2 polarization markers. PRC overexpression and siRNA silencing in microglia, qPCR for M2 marker genes, co-immunoprecipitation or co-activation assay with STAT6 Journal of molecular neuroscience Low 24838382
2015 Heterozygous Pprc1 knockout male mice fed a high-fat diet were resistant to diet-induced obesity with decreased adipose tissue due to elevated energy expenditure. In skeletal muscle of Pprc1+/- mice, Pprc1 showed haplo-insufficiency with down-regulation of Pgc1b and Pgc1a, while adipose tissue showed compensatory upregulation of other PGC-1 family members and respiratory chain genes, establishing Pprc1's role in controlling mitochondrial gene expression and energy metabolic processes in vivo. Heterozygous knockout mouse model, high-fat diet challenge, metabolic phenotyping (energy expenditure, adipose tissue mass), qPCR for mitochondrial and PGC-1 family genes Endocrine journal Medium 25994039
2020 PPRC1 expression levels directly correlate with expression of mitochondrial proteins TFAM and SDHA in human dermal fibroblasts across multiple cell lines, whereas PGC-1α expression does not, suggesting PPRC1 is a functionally active regulator of mitochondrial biogenesis in fibroblasts. PGC-1α knockdown led to a slight decrease in TFAM protein and mtDNA-encoded MT-CO2, supporting cooperative roles for PGC-1α and PPRC1. Gene expression correlation across 10 cell lines, siRNA knockdown of PGC-1α, protein expression analysis (TFAM, SDHA, MT-CO2) Genetics and molecular biology Low 32639509
2021 COL5A1 overexpression in glioblastoma upregulates PPRC1 and downstream ESM1, promoting cell mobility, metastatic ability, and actin polymerization, placing PPRC1 as an intermediate transcription factor in the COL5A1-PPRC1-ESM1 signaling axis in GBM. Transcriptomics dataset from COL5A1 overexpression, IPA pathway analysis, functional validation of cell mobility and actin polymerization Cell death discovery Low 34702798
2025 Eugenol inhibits AML cell growth and promotes apoptosis through the mitochondrial pathway by downregulating PPRC1 at both protein and mRNA levels and reducing mitochondrial membrane potential, establishing PPRC1 as a pro-survival regulator of mitochondrial biogenesis in AML cells. Eugenol treatment of AML cell lines and primary patient cells, apoptosis assays, qPCR and western blot for PPRC1, mitochondrial membrane potential measurement, cytarabine-resistant cell testing Cells Medium 39996733
2021 A novel heterozygous point mutation in PPRC1 (c.2902C>T, p.Thr958Ile) segregated with premature ovarian failure in a Chinese family. In vitro expression of PPRC1 in COV434 granulosa cells suggested PPRC1 is involved in regulating granulosa cell apoptosis but not senescence. Whole exome sequencing, Sanger sequencing, pedigree analysis, PPRC1 overexpression in granulosa cells, apoptosis assay, senescence staining The journal of gene medicine Low 33818872

Source papers

Stage 0 corpus · 76 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Molecular endocrinology (Baltimore, Md.) 221 16339279
1991 Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. Journal of bacteriology 132 1856173
1996 Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA. Journal of bacteriology 127 8576052
2006 Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases. Molecular microbiology 123 17020580
1996 An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity. Molecular endocrinology (Baltimore, Md.) 90 8923464
2008 Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. The Journal of biological chemistry 60 19036724
2008 Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms. Endocrinology 55 18617611
2004 High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain. Biotechnology and bioengineering 54 14760686
1997 An N-terminally truncated third progesterone receptor protein, PR(C), forms heterodimers with PR(B) but interferes in PR(B)-DNA binding. The Journal of steroid biochemistry and molecular biology 53 9408082
2004 The PRC-barrel domain of the ribosome maturation protein RimM mediates binding to ribosomal protein S19 in the 30S ribosomal subunits. RNA (New York, N.Y.) 51 15496525
2017 Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc. Nature communications 42 29138488
2005 Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa. Microbiology (Reading, England) 42 16000715
2002 The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism. Genome biology 42 12429060
2012 ROS-scavenger and radioprotective efficacy of the new PrC-210 aminothiol. Radiation research 41 22702647
2013 Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus 38 23966131
2021 Type V collagen alpha 1 chain promotes the malignancy of glioblastoma through PPRC1-ESM1 axis activation and extracellular matrix remodeling. Cell death discovery 37 34702798
1994 Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12. Molecular & general genetics : MGG 35 8159175
2010 Regulation of subtilisin-like protease prC expression by nematode cuticle in the nematophagous fungus Clonostachys rosea. Environmental microbiology 32 20636375
2014 The Prc and RseP proteases control bacterial cell-surface signalling activity. Environmental microbiology 31 24373018
1992 Multiple antibiotic susceptibility associated with inactivation of the prc gene. Journal of bacteriology 30 1447154
2004 Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease. Journal of biochemistry 29 15047720
2008 Comparison of BGM and PLC/PRC/5 cell lines for total culturable viral assay of treated sewage. Applied and environmental microbiology 28 18326686
2020 Identification of MltG as a Prc Protease Substrate Whose Dysregulation Contributes to the Conditional Growth Defect of Prc-Deficient Escherichia coli. Frontiers in microbiology 25 32973722
2016 Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction. The Journal of biological chemistry 24 27789709
1999 MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential. Journal of cellular physiology 24 10528237
2014 The periplasmic PDZ domain-containing protein Prc modulates full virulence, envelops stress responses, and directly interacts with dipeptidyl peptidase of Xanthomonas oryzae pv. oryzae. Molecular plant-microbe interactions : MPMI 23 24200074
2020 The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli. Journal of biomedical science 22 31900139
2022 A Cell Wall Hydrolase MepH Is Negatively Regulated by Proteolysis Involving Prc and NlpI in Escherichia coli. Frontiers in microbiology 21 35418955
2014 Salinity-dependent impacts of ProQ, Prc, and Spr deficiencies on Escherichia coli cell structure. Journal of bacteriology 21 24443528
2013 Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. The Journal of biological chemistry 19 23364789
1982 Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus. Molecular and cellular biology 19 6290871
2016 Functional characterization and transcriptome analysis reveal multiple roles for prc in the pathogenicity of the black rot pathogen Xanthomonas campestris pv. campestris. Research in microbiology 18 26804425
2010 Expression of a serine protease gene prC is up-regulated by oxidative stress in the fungus Clonostachys rosea: implications for fungal survival. PloS one 18 20976223
2020 PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression. The Journal of biological chemistry 16 33087445
2010 The zebrafish genes encoding the Polycomb repressive complex (PRC) 1. Gene 16 21195142
1982 Expression of the PRC II avian sarcoma virus genome. Journal of virology 16 6284969
2007 Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT). Journal of pediatric hematology/oncology 15 17984691
2017 Point-of-care washing of allogeneic red blood cells for the prevention of transfusion-related respiratory complications (WAR-PRC): a protocol for a multicenter randomised clinical trial in patients undergoing cardiac surgery. BMJ open 14 28821525
2013 PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity. Biochemical and biophysical research communications 13 23954632
2014 PGC-1-related coactivator (PRC) is an important regulator of microglia M2 polarization. Journal of molecular neuroscience : MN 12 24838382
1983 Simultaneous measurements of estrogen nuclear (E2Rn) and progestin cytosol (PRc) receptors in the hypothalamus and pituitary gland of rats. Journal of receptor research 12 6672190
2018 Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector. Radiation research 11 29781766
2012 Splice variant PRKC-ζ(-PrC) is a novel biomarker of human prostate cancer. British journal of cancer 10 22644296
2019 Significant Reduction of Murine Renal Ischemia-Reperfusion Cell Death Using the Immediate-Acting PrC-210 Reactive Oxygen Species Scavenger. Transplantation direct 9 31334343
2019 Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger. Pharmacology research & perspectives 9 31338199
2013 Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease. International microbiology : the official journal of the Spanish Society for Microbiology 9 24400526
2020 Significant Improvement in Rat Kidney Cold Storage Using UW Organ Preservation Solution Supplemented With the Immediate-Acting PrC-210 Free Radical Scavenger. Transplantation direct 8 33134502
2014 Association of Deficiency of Coagulation Factors (Prs, Prc, ATIII) and FVL Positivity with Preeclampsia and/or Eclampsia in Pregnant Women. International journal of hematology-oncology and stem cell research 8 25774262
1998 A PRC based model of a pacemaker cell: effect of vagal activity and investigation of the respiratory sinus arrhythmia. Journal of theoretical biology 8 9637059
1990 Characteristics of Parker's rat coronavirus (PRC) replicated in L-2 cells. Archives of virology 8 2378568
2022 OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues. Molecular microbiology 7 36115022
2018 Reduction of X-ray-induced DNA damage in normal human cells treated with the PrC-210 radioprotector. Biology open 7 30135082
2023 NlpI-Prc Proteolytic Complex Mediates Peptidoglycan Synthesis and Degradation via Regulation of Hydrolases and Synthases in Escherichia coli. International journal of molecular sciences 6 38003545
2015 Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Endocrine journal 6 25994039
2023 Widespread PRC barrel proteins play critical roles in archaeal cell division. bioRxiv : the preprint server for biology 5 37090588
2021 Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats. Biomolecules 5 34356678
1996 A new Bacillus subtilis gene with homology to Escherichia coli prc. Gene 5 8996100
2025 Eugenol Promotes Apoptosis in Leukemia Cells via Targeting the Mitochondrial Biogenesis PPRC1 Gene. Cells 4 39996733
2023 The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa. iScience 4 37534181
2023 PrC-210 Protects against Radiation-Induced Hematopoietic and Intestinal Injury in Mice and Reduces Oxidative Stress. Antioxidants (Basel, Switzerland) 3 37507957
2020 PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts. Genetics and molecular biology 3 32639509
2021 Characterization of a Novel Chromosome-Encoded AmpC β-Lactamase Gene, bla PRC-1, in an Isolate of a Newly Classified Pseudomonas Species, Pseudomonas wenzhouensis A20, From Animal Farm Sewage. Frontiers in microbiology 2 34975778
2024 Significantly Improved Cold Preservation of Rat Hind Limb Vascularized Composite Allografts Using the New PrC-210 Free Radical Scavenger. International journal of molecular sciences 1 38338887
2024 In vivo and in vitro analyses of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa. Journal of bacteriology 1 39287400
2019 Specific Reconstruction on pRC Plasmid to Facilitate Its Universal Chromosomal Integration in Different Ralstonia solanacearum Species Complex Strains. Molecular plant-microbe interactions : MPMI 1 30958087
2019 Impact of the PrC-210 Radioprotector Molecule on Cancer Deaths in p53-Deficient Mice. Radiation research 1 31738662
2013 [Polymorphism analysis on the genotypes of circumsporozoite protein of Plasmodium vivax with PRC-RFLP]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 1 24818420
1997 [Experimental studies on somatic gene therapy for diabetes. I. Structuring of recombinant from human insulin gene and ammalian expression vector PRC/CMV]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 1 10453511
2026 A new sensitive derivatization assay of PrC-210 in plasma and tissues using liquid chromatography coupled with tandem mass spectrometry. Bioanalysis 0 41684060
2025 The PDZ Domain-Containing Protein Prc Is Involved in Virulence and Stress Tolerance in the Poplar Canker Bacterium Lonsdalea populi. Phytopathology 0 40434399
2025 Periplasmic Serine Protease Prc is Responsible for Amyloid Subunit CsgA Degradation and Proteostasis in Escherichia coli. Journal of molecular biology 0 40907937
2024 In vivo and in vitro analysis of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa. bioRxiv : the preprint server for biology 0 38854061
2024 Significant Reduction of Radiation-Induced Death in Mice Treated with PrC-210 and G-CSF after Irradiation. Radiation research 0 39142656
2023 Tachycardia and fever after packed red cell (PRC) infusion: A case report. Journal of family medicine and primary care 0 37649762
2021 A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study. The journal of gene medicine 0 33818872
1999 Inhibition of metastasis to lung of a human nasopharyngeal carcinoma cell line CNE- 2L2 transfected with pRc/ CMV-antisense 6A8 cDNA in nude mice. Science in China. Series C, Life sciences 0 18726475