Affinage

FZD6

Frizzled-6 · UniProt O60353

Length
706 aa
Mass
79.3 kDa
Annotated
2026-04-28
49 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FZD6 is a seven-transmembrane Frizzled family receptor that functions as a context-dependent modulator of Wnt signaling, acting as either a negative regulator of the canonical Wnt/β-catenin pathway or a positive transducer depending on cellular context. In its repressive mode, FZD6 activates the CaMKII–TAK1–NLK cascade to block TCF/LEF binding to target DNA without affecting β-catenin stabilization, thereby attenuating canonical Wnt-driven transcription (PMID:14747478, PMID:27698350); in cancer and neuronal contexts, FZD6 instead promotes β-catenin nuclear translocation, engaging canonical Wnt target genes and additionally regulating DNA double-strand break repair through SRC/STAT3 and WEE1/PLK1 (PMID:30833544, PMID:41286306, PMID:40810359). Loss-of-function mutations in FZD6 cause autosomal-recessive nail dysplasia in humans, and Fzd6 loss in the hippocampus reduces GSK3β phosphorylation and β-catenin levels, decreasing neural progenitor proliferation and producing depressive-like behavior (PMID:22211385, PMID:37321345).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2004 High

    Establishing that FZD6 negatively regulates canonical Wnt signaling resolved how a Frizzled receptor could paradoxically repress the pathway it was expected to transduce, revealing a TAK1–NLK mechanism that blocks TCF/LEF–DNA binding without destabilizing β-catenin.

    Evidence Co-expression and luciferase reporter assays, EMSA, and deletion mutagenesis in mammalian cells with LiCl-mediated GSK-3β inhibition

    PMID:14747478

    Open questions at the time
    • Endogenous ligand activating FZD6's repressive mode was not identified
    • No co-receptor requirement investigated
    • Structural basis for N- and C-terminal requirement undefined
  2. 2012 Medium

    Identification of FZD6 loss-of-function mutations as the cause of autosomal-recessive nail dysplasia established the first human disease directly attributable to FZD6 deficiency and linked it to Wnt-dependent nail morphogenesis.

    Evidence Genome-wide linkage analysis, Sanger sequencing, and immunohistochemistry of human nail tissue

    PMID:22211385

    Open questions at the time
    • Specific downstream Wnt branch (canonical vs. PCP) disrupted in nail dysplasia not resolved
    • Functional rescue of mutant alleles not performed
    • Mechanism of nail plate guidance not defined
  3. 2011 Medium

    Demonstrating that Fzd6 knockdown in the hippocampus produces anxiety- and depressive-like behavior revealed a CNS function for FZD6 as a CREB target gene linking Wnt signaling to mood regulation.

    Evidence ChIP-chip identification of CREB binding, viral vector-mediated Fzd6 knockdown in rodent hippocampus, behavioral phenotyping

    PMID:21937024

    Open questions at the time
    • Downstream Wnt effectors mediating the behavioral phenotype not identified
    • Cell-type specificity within hippocampus not resolved
  4. 2016 High

    Placement of FZD6 within a CaMKII–TAK1–NLK–STAT3/NF-κB signaling network in glioblastoma demonstrated how the same TAK1–NLK axis originally shown in non-cancer cells could redirect signaling to promote the mesenchymal tumor subtype, resolving the dual identity of FZD6 as both Wnt repressor and pro-tumorigenic effector.

    Evidence Gain/loss-of-function assays, pathway reporters, GBM cell lines, and in vivo xenograft models

    PMID:27698350

    Open questions at the time
    • Ligand driving FZD6 signaling in GBM microenvironment not established
    • Whether STAT3/NF-κB activation requires direct FZD6 scaffolding or is indirect unknown
  5. 2018 Medium

    Discovery that lncFZD6 recruits BRG1/SWI-SNF to the FZD6 promoter, and that WNT5A acts as a FZD6 ligand activating canonical Wnt/β-catenin signaling in liver tumor-initiating cells, established a feed-forward transcriptional circuit controlling FZD6 expression and its cancer-promoting canonical Wnt output.

    Evidence RNA immunoprecipitation, ChIP, promoter reporters, tumor sphere and tumor initiation assays in liver TIC models

    PMID:29535420

    Open questions at the time
    • How the same receptor transduces canonical activation via WNT5A while repressing canonical signaling via TAK1–NLK in other contexts is mechanistically unresolved
    • Co-receptor requirements for WNT5A–FZD6 not tested
  6. 2019 Medium

    Demonstration that NPTX2 physically interacts with FZD6 to promote β-catenin nuclear translocation and canonical Wnt target expression identified an unconventional non-Wnt ligand capable of activating FZD6-mediated canonical signaling in colorectal cancer.

    Evidence Co-immunoprecipitation, siRNA knockdown and rescue, in vitro/in vivo proliferation and metastasis assays

    PMID:30833544

    Open questions at the time
    • Binding interface between NPTX2 and FZD6 undefined
    • Whether NPTX2 competes with Wnt ligands for FZD6 binding not tested
  7. 2021 Medium

    Identification of WNT10B as a ligand forming a protein complex with FZD6 in T-ALL established a disease-specific Wnt–FZD6 axis druggable by PORCN inhibition, extending the receptor's ligand repertoire beyond WNT5A.

    Evidence Co-immunoprecipitation of WNT10B/FZD6 complex, shRNA knockdown, PORCN inhibitor LGK974 treatment in T-ALL cells

    PMID:33497493

    Open questions at the time
    • Co-receptor (e.g., LRP5/6) involvement not characterized
    • Downstream effector branch (canonical vs. non-canonical) not fully resolved
  8. 2022 Medium

    Genetic deletion of FZD6 in melanoma cells dramatically reduced invasion and lung metastasis in vivo, linking FZD6 to EMT and establishing it as a functional driver of metastatic spread.

    Evidence siRNA/CRISPR-KO, invasion assays, Pten/BRaf mouse melanoma model, Wnt/EMT marker analysis

    PMID:36368445

    Open questions at the time
    • Specific ligand activating FZD6 in melanoma not identified
    • Whether the EMT role is TAK1–NLK-dependent or β-catenin-dependent not distinguished
  9. 2023 High

    Multiple 2023 studies convergently expanded FZD6's mechanistic repertoire: FZD6 knockdown in prostate cancer impaired DNA DSB repair via SRC/STAT3 and WEE1/PLK1; FZD6 promoted β-catenin nuclear translocation to suppress pyroptosis and confer 5-FU resistance in colorectal cancer; and hippocampal Fzd6 loss reduced GSK3β phosphorylation and β-catenin, decreasing neural proliferation and producing depressive behavior.

    Evidence CRISPR kinome screen plus PDX models (prostate cancer); lentiviral KD/OE with immunofluorescence and pyroptosis markers (CRC); CRISPR/Cas9 KD mouse with behavioral phenotyping and western blot (hippocampus)

    PMID:37321345 PMID:40810359 PMID:41286306

    Open questions at the time
    • How FZD6 engages SRC kinase directly versus through intermediate adaptors is unknown
    • Structural or biochemical basis for FZD6-dependent β-catenin nuclear translocation not defined
    • Whether hippocampal and cancer phenotypes share common downstream effectors is unclear
  10. 2024 Medium

    Shear-stress-induced spatial reorganization of FZD6 at the plasma membrane through Vangl1-dependent mutual exclusion provided the first direct evidence for FZD6 functioning in mammalian planar cell polarity signaling to coordinate endothelial alignment and vessel sprouting.

    Evidence Live imaging, subcellular fractionation, endocytosis/exocytosis assays, Vangl1 loss-of-function, in vivo vascular studies (preprint)

    PMID:bio_10.1101_2024.06.25.600357

    Open questions at the time
    • Peer review pending
    • Direct physical interaction between FZD6 and Vangl1 not demonstrated biochemically
    • Whether asymmetric FZD6 localization requires Dvl scaffolding not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • A central unresolved question is how the same FZD6 receptor switches between TAK1–NLK-mediated canonical Wnt repression, β-catenin nuclear translocation and canonical activation, and planar cell polarity signaling in different cellular contexts — the molecular determinants of this context-dependent switch remain unknown.
  • No structural model of FZD6 ligand–receptor–co-receptor complexes exists
  • Identity of the adaptor(s) or co-receptors that dictate pathway choice at FZD6 is unknown
  • Whether post-translational modifications of FZD6 control pathway switching has not been tested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-1643685 Disease 6 R-HSA-1266738 Developmental Biology 2 R-HSA-73894 DNA Repair 1
Partners
NLKNPTX2TAK1VANGL1WNT10BWNT5A

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 HFz6 acts as a negative regulator of canonical Wnt/β-catenin signaling by inhibiting TCF/LEF binding to target DNA without affecting β-catenin stabilization or nuclear TCF4 levels. HFz6 activates the TAK1-NLK pathway, which blocks TCF/LEF binding to target promoters, thereby inhibiting β-catenin-driven transcription. Both N- and C-terminal sequences of HFz6 are required for this repressive activity. Co-expression assays, luciferase reporter assays, electrophoretic mobility shift assays (EMSA), deletion mutagenesis, LiCl-mediated GSK-3β inhibition The Journal of biological chemistry High 14747478
2016 FZD6 activates CaMKII-TAK1-NLK signaling, which attenuates canonical Wnt pathway activity while promoting STAT3 and NF-κB signaling, establishing FZD6 as a negative regulator of Wnt/β-catenin and a driver of the mesenchymal GBM phenotype. A TCF4-miR-125b/miR-20b-FZD6 regulatory circuit controls GBM subtype identity. Gain- and loss-of-function assays, pathway reporter assays, GBM cell line models, in vivo xenograft validation Nature communications High 27698350
2012 Loss-of-function mutations in FZD6 cause autosomal-recessive nail dysplasia in humans. Immunohistochemistry showed strong FZD6 expression in the ventral nail matrix and nail bed, indicating a pivotal role in nail plate growth and guidance via Wnt signaling. Genome-wide linkage analysis, Sanger sequencing, immunohistochemistry on nail sections The British journal of dermatology Medium 22211385
2011 Viral vector-mediated inhibition of Fzd6 in the hippocampus of rodents produced anxiety- and depressive-like behavior, establishing Fzd6 as a CREB target gene regulated by chronic electroconvulsive seizure with a functional role in mood-related behavior. Chromatin immunoprecipitation-microarray (ChIP-chip), viral vector-mediated gene knockdown, behavioral models of depression (open field, forced swim, tail suspension) Biological psychiatry Medium 21937024
2019 NPTX2 physically interacts with FZD6 to promote β-catenin nuclear translocation and activate canonical Wnt/β-catenin target gene expression (MYC, cyclin D1, snail, N-cadherin) in colorectal cancer cells. FZD6 knockdown nearly completely reversed NPTX2-mediated proliferative effects. Co-immunoprecipitation, siRNA knockdown, in vitro and in vivo proliferation/metastasis assays, western blot for pathway targets Cell death & disease Medium 30833544
2018 A divergent lncRNA of FZD6 (lncFZD6) drives liver tumor-initiating cell (TIC) self-renewal by interacting with BRG1-embedded SWI/SNF complex and recruiting it to the FZD6 promoter, inducing chromatin remodeling and FZD6 transcription. WNT5A acts as a ligand of FZD6 in this context, activating Wnt/β-catenin signaling in liver TICs in an lncFZD6-BRG1-FZD6-dependent manner. RNA immunoprecipitation, ChIP, promoter reporter assays, loss- and gain-of-function, tumor sphere and tumor initiation assays Oncogene Medium 29535420
2021 PCAT-1 lncRNA directly interacts with FZD6 protein to regulate its stability and activate Wnt/β-catenin signaling in AML cells. FZD6 overexpression partially rescued the effects of PCAT-1 knockdown on proliferation, cell cycle, and apoptosis. RNA-protein interaction assays, gain- and loss-of-function, rescue experiments, western blot for Wnt pathway components American journal of translational research Low 31814913
2022 FZD6 knockdown or knockout significantly reduces the invasive ability of melanoma cells and dramatically reduces lung metastasis in the Pten/BRaf mouse model, with mechanistic studies revealing involvement of canonical Wnt signaling and epithelial-mesenchymal transition in the FZD6-mediated invasive phenotype. siRNA knockdown, CRISPR-KO, in vitro invasion assays, in vivo mouse melanoma model, western blot for Wnt/EMT markers The Journal of investigative dermatology Medium 36368445
2023 FZD6 knockdown in prostate cancer cells impairs DNA double-strand break (DSB) repair and reduces activities of SRC kinase and STAT3. DNA damage repair deficiency following FZD6 loss is mechanistically linked to WEE1 downregulation via PLK1. A CRISPR kinome screen revealed that FZD6 inhibition sensitizes prostate cancer cells to PKMYT1 inhibition. siRNA knockdown, patient-derived xenograft models, γH2AX foci resolution, DNA DSB repair reporter assays, CRISPR-Cas9 kinome-wide screen, western blot for SRC/STAT3/WEE1/PLK1 Oncogene High 41286306
2021 WNT10B drives Wnt activation through the FZD6 receptor complex in T-ALL cells, forming a WNT10B/FZD6 protein complex. shRNA-mediated knockdown of WNT10BIVS1 or pharmacological inhibition of WNT secretion (LGK974/PORCN inhibitor) reduces WNT10B/FZD6 complex formation and impairs downstream Wnt effectors and leukemic expansion. Co-immunoprecipitation (WNT10B/FZD6 complex), shRNA-mediated gene silencing, small molecule PORCN inhibition, leukemic cell proliferation assays Hematological oncology Medium 33497493
2024 Shear stress triggers spatial reorganization of Frizzled6 (Fzd6) at the plasma membrane through a Vangl1-dependent mechanism. Membrane enrichment of Vangl1 (via Coronin1C-dependent endo/exocytosis shift) results in mutual exclusion of core PCP proteins Fzd6 and Vangl1, augmenting differential junctional and cytoskeletal dynamics along the flow axis in endothelial cells to coordinate collective cell alignment and vessel sprouting. Live imaging, subcellular fractionation, endocytosis/exocytosis assays, Vangl1 loss-of-function, in vivo vascular studies, mathematical modeling bioRxivpreprint Medium bio_10.1101_2024.06.25.600357
2023 FZD6 overexpression promotes nuclear translocation of β-catenin, reduces NLRP3/caspase-1/GSDMD-mediated pyroptosis, and increases 5-FU resistance in colorectal cancer cells. Conversely, FZD6 knockdown decreases nuclear β-catenin, enhances pyroptosis, and reduces 5-FU resistance, establishing a FZD6→β-catenin nuclear translocation→pyroptosis suppression axis. Lentiviral FZD6 KD/OE, immunofluorescence for β-catenin localization, western blot for pyroptosis markers, electron microscopy for pyroptosis morphology, CCK-8/colony formation assays Carcinogenesis Medium 40810359
2023 CRISPR/Cas9-mediated Fzd6 knockdown in mice decreases phosphorylated GSK3β and cytoplasmic β-catenin in the hippocampus, decreases hippocampal cell proliferation (Ki67+, PCNA+ cells), and produces depressive-like behaviors, placing Fzd6 upstream of GSK3β and β-catenin in the canonical Wnt pathway in the hippocampus. CRISPR/Cas9 Fzd6 knockdown mouse model, behavioral tests (FST, SPT, OFT, EPM), immunofluorescence (Ki67, PCNA), western blot for GSK3β/β-catenin, qRT-PCR Journal of advanced research Medium 37321345
2023 Fzd6 mutation (Fzd6Q152E) in mice decreases serum BDNF, 5-HT, and noradrenaline, increases Dkk2 and Gsk-3β expression, and decreases Lrp6 and Fzd6 protein levels, implicating Fzd6 in regulation of the Wnt pathway and neurotransmitter systems relevant to depression. CRISPR/Cas9 Fzd6Q152E knock-in mice, ELISA for BDNF/5-HT/NE, western blot and qRT-PCR for Wnt pathway genes, Nissl staining Molecular biology reports Low 35980530
2024 FLD (Fengshi Liuhe Decoction) downregulates Fzd6 expression in CIA rat fibroblast-like synoviocytes and suppresses NF-κB signaling (reducing p-p65 and p-IκBα), inhibiting nuclear translocation of NF-κB p65 and reducing inflammatory cytokines (COX-2, IL-8, TNF-α), identifying a Fzd6/NF-κB signaling axis in synovial inflammation. qPCR, western blot, ELISA for cytokines, nuclear translocation assay for NF-κB p65, CIA rat FLS model Gene Low 38710294
2025 HOXC10 transcription factor binds to the FZD6 promoter region and reduces FZD6 expression, thereby activating the Wnt/β-catenin signaling pathway to delay skin cell senescence and aging. Single-cell transcriptomics, ChIP (HOXC10 binding to FZD6 promoter), gain- and loss-of-function in fibroblasts, in vivo aging models Research (Washington, D.C.) Medium 41268215

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. The Journal of biological chemistry 118 14747478
2017 Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage. Oncogenesis 96 28737757
2016 A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nature communications 81 27698350
2011 FZD6 is a novel gene for human neural tube defects. Human mutation 81 22045688
2020 Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis. Journal of cellular physiology 63 32557673
2019 Long noncoding RNA DLX6-AS1 promotes tumorigenesis by modulating miR-497-5p/FZD4/FZD6/Wnt/β-catenin pathway in pancreatic cancer. Cancer management and research 62 31118816
2018 LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation. Oncogene 61 29535420
2019 NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6. Cell death & disease 54 30833544
2015 FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer. BMB reports 54 25772759
2018 Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics. Scientific reports 46 29867083
2021 FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/β-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 42 34564982
2016 FZD6, targeted by miR-21, represses gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. American journal of translational research 41 27347343
2020 Long non-coding RNA CASC9 promotes tumor growth and metastasis via modulating FZD6/Wnt/β-catenin signaling pathway in bladder cancer. Journal of experimental & clinical cancer research : CR 34 32677984
2012 FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia. The British journal of dermatology 34 22211385
2015 Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family. Molecular genetics & genomic medicine 23 26436110
2013 Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining. Brain tumor pathology 22 23748645
2023 circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling. Journal of experimental & clinical cancer research : CR 21 36932454
2011 Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression. Biological psychiatry 21 21937024
2019 lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway. American journal of translational research 18 31814913
2010 Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. Carcinogenesis 14 20472610
2022 FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial‒Mesenchymal Transition. The Journal of investigative dermatology 13 36368445
2021 CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling. Environmental toxicology 12 34850997
2021 miR-199b-5p enhances the proliferation of medullary thymic epithelial cells via regulating Wnt signaling by targeting Fzd6. Acta biochimica et biophysica Sinica 11 33313638
2021 The flavonoid luteolin suppresses infantile hemangioma by targeting FZD6 in the Wnt pathway. Investigational new drugs 11 33411210
2014 Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 11 24816679
2024 Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2. eLife 10 38770735
2016 Isolated recessive nail dysplasia caused by FZD6 mutations: report of three families and review of the literature. Clinical and experimental dermatology 10 27786367
2023 CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/β-catenin signaling pathway. Journal of advanced research 9 37321345
2021 FZD6 triggers Wnt-signalling driven by WNT10BIVS1 expression and highlights new targets in T-cell acute lymphoblastic leukemia. Hematological oncology 9 33497493
2021 Role of Fzd6 in Regulating the Osteogenic Differentiation of Adipose-derived Stem Cells in Osteoporotic Mice. Stem cell reviews and reports 9 34041696
2012 A novel missense mutation in the gene FZD6 underlies autosomal recessive nail dysplasia. The British journal of dermatology 9 22861124
2019 A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia. BMC medical genetics 8 30642273
2023 Long non-coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β-catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1. The journal of gene medicine 6 38009760
2023 SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/β-catenin signaling in colorectal carcinoma. Heliyon 5 38046159
2025 FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer. Carcinogenesis 4 40810359
2024 Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice. Journal of affective disorders 4 39643213
2022 Construction of Fzd6Q152E mice through CRISPR/Cas9 technology and their reproduction and identification. Molecular biology reports 4 35980530
2019 A novel FZD6 mutation revealed the cause of cleft lip and/or palate in a Chinese family. Genes & diseases 4 32884998
2021 The Expression of Selected Wnt Pathway Members (FZD6, AXIN2 and β-Catenin) in Canine Oral Squamous Cell Carcinoma and Acanthomatous Ameloblastoma. Animals : an open access journal from MDPI 3 34072517
2024 Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the Fzd6/NF-κB signaling axis. Gene 2 38710294
2017 A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a large Iranian kindred. Journal of dermatological science 2 28545862
2025 Dual Functions and Therapeutic Potential of FZD6 in Biliary Atresia. Digestive diseases and sciences 1 40618286
2025 Targeting FZD6 creates therapeutically actionable vulnerabilities for advanced prostate cancer. Oncogene 1 41286306
2023 Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma. Translational neuroscience 1 37554539
2022 Comprehensive Genomic Analysis for Identifying FZD6 as a Novel Diagnostic Biomarker for Acute Myeloid Leukemia. Computational and mathematical methods in medicine 1 36452482
2026 Inhibition of PD-L1 in tubular epithelial cells attenuates renal fibrosis by suppressing TGFβR1 and FZD6 signaling. International immunopharmacology 0 41990703
2025 FZD6 mediates the contributing role of miR-199a-5p in the adipogenesis of bone marrow mesenchymal stem cells derived from aplastic anemia. Scientific reports 0 41198743
2025 HOXC10 Protects from Skin Aging by Targeting the FZD6/Wnt/β-Catenin Signaling Pathway. Research (Washington, D.C.) 0 41268215
2019 First Report of a Known Pathogenic Variant in the FZD6 Gene, in an Iranian Family with Recessive Nail Dysplasia: A Case Report. Iranian journal of public health 0 31497560