Affinage

FOXP1

Forkhead box protein P1 · UniProt Q9H334

Length
677 aa
Mass
75.3 kDa
Annotated
2026-06-09
100 papers in source corpus 47 papers cited in narrative 48 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FOXP1 is a forkhead-domain transcription factor that acts predominantly as a sequence-specific transcriptional repressor—and context-dependent activator—to control cell fate, proliferation, and quiescence decisions across diverse developmental and immune lineages (PMID:12692134, PMID:20713518). It binds a preferred consensus DNA site and functions as homo- or heterodimers with other FOXP-subfamily members (FOXP2/FOXP4), with the dimerization interface mapped to a conserved C2H2 zinc finger/leucine zipper motif and, biophysically, to domain-swapped DNA-binding domains stabilized by intrinsically disordered regions; alternative splicing of functional domains adds a further regulatory layer (PMID:12692134, PMID:25027557, PMID:32735805). In B-cell development FOXP1 binds the Erag enhancer to drive RAG1/RAG2 expression and V(D)J recombination, sustains mature B-cell survival via direct binding of the Bcl2l1 (Bcl-xl) locus, and represses the plasma-cell program by silencing PRDM1, IRF4, and XBP1 (PMID:16819554, PMID:29507226, PMID:26289642). In T cells it enforces naive quiescence by repressing IL-7Rα through antagonism of Foxo1 and restraining MEK/Erk signaling, suppresses TH9/IL-9 differentiation through competition with Foxo1 at the Il9 promoter, and partners with Foxp3 at co-occupied genomic sites and the Foxp3 CNS2 element to maintain Treg fitness and CTLA-4 expression (PMID:21532575, PMID:29018172, PMID:30643266, PMID:31125332). During organogenesis FOXP1 directs cardiac outflow-tract septation and cardiomyocyte proliferation by repressing Sox17 (to derepress Fgf ligands) and Nkx2.5 (PMID:15342473, PMID:20713518), cooperates with Foxp2/Foxp4 in lung and esophageal morphogenesis and goblet-cell restriction via T1alpha and Agr2 (PMID:17428829, PMID:22675208), and governs stem/progenitor quiescence and identity by repressing Fgf18, Jagged1/Notch, and p16INK4A while regulating MSC, neural, retinal, and cortical progenitor fate (PMID:23946441, PMID:29141232, PMID:28240601, PMID:32049024, PMID:36924502). In the brain FOXP1 specifies striatal medium spiny neuron and motor-neuron identity, regulating Lhx3 and Pitx3, and its loss produces striatal, hippocampal, mitochondrial, and autism-relevant behavioral and vocalization deficits (PMID:19797899, PMID:20175877, PMID:25266127, PMID:26494785, PMID:35165191). FOXP1 is itself controlled at multiple levels—transcriptionally by KLF2 and androgen receptor, post-transcriptionally by PUM1/2 binding of its 3'UTR and NAT10-mediated ac4C mRNA modification, and by upstream ERK/JNK–cJUN/cFOS signaling (PMID:31318658, PMID:28204507, PMID:28232582, PMID:37818745, PMID:33716296). In cancer it serves as a survival and oncogenic factor, repressing S1PR2 and enforcing NF-κB/MYD88 programs in DLBCL and potentiating Wnt/β-catenin signaling through a β-catenin/TCF7L2/CBP complex (PMID:26729899, PMID:26787899, PMID:25650440).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2003 High

    Established FOXP1's basic biochemical identity—a consensus-site-binding transcriptional repressor that dimerizes through a defined zinc-finger/leucine-zipper motif and is diversified by alternative splicing.

    Evidence In vitro DNA-binding site isolation, luciferase repression assays, and dimerization domain mapping with isoform characterization

    PMID:12692134

    Open questions at the time
    • Did not define physiological target genes in vivo
    • Context determinants of activator vs repressor function unresolved
  2. 2004 High

    Demonstrated an essential developmental role in cardiac morphogenesis, placing FOXP1 upstream of Sox4 and Nfatc1 in outflow tract and cushion remodeling.

    Evidence Foxp1-null mouse embryos with histological and Sox4/Nfatc1 expression analysis

    PMID:15342473

    Open questions at the time
    • Direct vs indirect regulation of Sox4 not established
    • Cell-autonomy of the phenotype undefined at this stage
  3. 2006 High

    Revealed a lineage-specific gene-regulatory function in early B-cell development, linking FOXP1 to RAG1/2 induction and V(D)J recombination via the Erag enhancer.

    Evidence Foxp1 knockout mice, expression profiling, and ChIP at the Erag enhancer

    PMID:16819554

    Open questions at the time
    • Cofactors at the Erag enhancer not identified
    • Whether activation vs relief of repression drives RAG induction unclear
  4. 2010 High

    Resolved cell-autonomous and non-cell-autonomous mechanisms by which FOXP1 tunes cardiomyocyte proliferation through repression of Sox17 (Fgf axis) and Nkx2.5, and extended its developmental reach to dopaminergic neuron identity via Pitx3.

    Evidence Lineage-specific conditional knockouts with Fgf20 and Nkx2.5 rescue/overexpression; ChIP/EMSA and ES-cell forced expression for Pitx3

    PMID:20175877 PMID:20713518

    Open questions at the time
    • How a single factor switches between repression and activation across loci unresolved
    • Direct binding at Sox17 vs Nkx2.5 distinguished only partially
  5. 2011 High

    Defined FOXP1 as a master enforcer of naive T-cell quiescence, acting through Foxo1 antagonism and MEK/Erk restraint.

    Evidence Acute and conditional Foxp1 deletion with in vitro IL-7 stimulation and adoptive transfer

    PMID:21532575

    Open questions at the time
    • Mechanism of Foxo1 antagonism (competition vs sequestration) only later resolved
    • Direct vs indirect MEK/Erk regulation unclear
  6. 2013 High

    Generalized the quiescence role to epithelial stem cells (Fgf18-dependent) and uncovered dual activator/repressor behavior governing the germinal-center reaction, overlapping with BCL6 targets.

    Evidence Conditional skin knockout with FGF18 rescue; ChIP-on-chip and FOXP1 transgenic mice with GC and class-switch readouts

    PMID:23580662 PMID:23946441

    Open questions at the time
    • Determinants of FOXP1/BCL6 target sharing unresolved
    • Switch between activation and repression at GC genes uncharacterized
  7. 2015 High

    Established FOXP1 as a survival-promoting oncogenic factor in lymphoma, repressing the plasma-cell program (PRDM1/IRF4/XBP1) and potentiating Wnt/β-catenin signaling through a β-catenin/TCF7L2/CBP complex.

    Evidence ChIP-seq and gain-of-function in primary human B cells; MS-coupled screen, reciprocal co-IP, acetylation assays, and zebrafish/xenograft validation

    PMID:25650440 PMID:26289642

    Open questions at the time
    • Direct DNA binding vs cofactor-mediated recruitment at Wnt promoters not fully separated
    • Generality of CBP/β-catenin acetylation mechanism beyond DLBCL untested
  8. 2016 High

    Identified direct DLBCL survival targets and the broader transcriptional network enforced by FOXP1, repressing pro-apoptotic S1PR2 and Bcl2l1-dependent survival while enforcing NF-κB/MYD88 programs.

    Evidence ChIP plus expression profiling after depletion with signaling-dead S1PR2 rescue and tumor models; ChIP at Bcl2l1 with Bcl2 transgenic rescue; genome-wide ChIP in ABC-DLBCL

    PMID:26729899 PMID:26787899 PMID:29507226

    Open questions at the time
    • Determinants of subtype-specific transcriptional output (ABC vs GCB) incompletely defined
  9. 2017 High

    Connected FOXP1 to stem/progenitor fate and senescence through repression of p16INK4A, Jagged1/Notch, and partnership with CEBPβ/δ and RBPjκ, and linked it to upstream PUM1/2 control and androgen signaling.

    Evidence Conditional MSC depletion with p16INK4A rescue and cofactor interaction studies; NSC ChIP-seq with Jagged1 rescue; PUM1/2 3'UTR binding; androgen receptor KO epistasis

    PMID:28204507 PMID:28232582 PMID:28240601 PMID:29141232

    Open questions at the time
    • How FOXP1 integrates parallel partner complexes at distinct loci unresolved
    • Non-canonical activation of FOXP1 by PUM proteins mechanistically incomplete
  10. 2019 High

    Defined FOXP1 as a genome-wide partner of Foxp3 stabilizing Treg identity and function, and extended its repressive output to vascular inflammation, metabolism, and the KLF2 regulatory axis.

    Evidence Treg conditional KO with genome-wide Foxp1/Foxp3 ChIP and IL-2 rescue; ChIP at Foxp3 CNS2; endothelial KO/overexpression with inflammasome and KLF2 analysis; adipose KO with β3-AR repression

    PMID:30643266 PMID:31125332 PMID:31318658 PMID:31699980

    Open questions at the time
    • Mechanism of Foxp1-enhanced Foxp3 chromatin occupancy unresolved
    • Whether shared targets are co-bound or sequentially regulated unclear
  11. 2020 High

    Used single-cell resolution to define cell-type-specific FOXP1 transcriptional programs governing striatal architecture and cortical progenitor identity/neurogenesis.

    Evidence scRNA-seq of conditional KO striatum; conditional KO and overexpression with in utero electroporation and human corticogenesis data

    PMID:32049024 PMID:32130906

    Open questions at the time
    • Direct vs indirect cell-type-specific targets not all validated by binding
    • Human-specific basal RG role correlative
  12. 2020 High

    Provided a biophysical basis for FOXP1 dimerization, showing intrinsically disordered regions drive domain-swapped DNA-binding-domain dimers.

    Evidence Single-molecule FRET, HDX-MS, and molecular dynamics on the FoxP1 DNA-binding domain

    PMID:32735805

    Open questions at the time
    • Functional consequence of domain swapping for target selection in cells untested
    • Relationship to the zinc-finger/leucine-zipper dimerization domain unresolved
  13. 2022 Medium

    Linked FOXP1 haploinsufficiency to mitochondrial dysfunction and oxidative stress in striatum, and to antioxidant control via SIRT1 stabilization in myeloid cells, broadening its role into metabolic and redox homeostasis.

    Evidence Foxp1+/- mice with complex I/membrane potential and antioxidant assays; FOXP1 knockdown in AML with SIRT1 protein-stability and chemosensitivity assays

    PMID:35165191 PMID:36930820

    Open questions at the time
    • Direct transcriptional vs indirect control of mitochondrial genes not fully separated
    • Post-transcriptional SIRT1 stabilization mechanism uncharacterized
  14. 2023 Medium

    Positioned FOXP1 as a regulatory hub for stem-like CD8+ T-cell states and a node in tumor metabolic immunosuppression controlled by ac4C mRNA modification.

    Evidence Single-cell multiome of CAR T cells with FOXP1 perturbation; NAT10 ac4C modification of FOXP1 mRNA with downstream GLUT4/KHK glycolysis analysis

    PMID:37818745 PMID:38012417

    Open questions at the time
    • Direct FOXP1 targets in the stem-like CAR T network not fully mapped
    • Reader/effector of ac4C on FOXP1 translation undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how FOXP1 selects between repressor and activator output at individual loci and how its dimerization state, isoform composition, and partner availability combine to dictate cell-type-specific target choice.
  • No unifying rule linking domain-swapped dimer state to in vivo target selection
  • Isoform-specific genome-wide binding maps lacking
  • Mechanism converting context cues into activation vs repression unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0003677 DNA binding 4 GO:0098772 molecular function regulator activity 4
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 6 R-HSA-168256 Immune System 6 R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-162582 Signal Transduction 3
Partners
CREBBPCTNNB1FOXP2FOXP3FOXP4NFAT1RUNX2TCF7L2

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 FOXP1 functions as a transcriptional repressor that binds a preferred consensus DNA sequence and naturally occurring sites in SV40 and IL-2 promoters. FOXP1 isoforms (1A, 1C, 1D) can form homodimers and heterodimers with subfamily members (FOXP2); the dimerization domain was localized to an evolutionarily conserved C2H2 zinc finger and leucine zipper motif. The polyglutamine domain modulates repression strength in some contexts. Tissue-specific alternative splicing of functionally important domains provides an additional level of regulation. Structure/function analysis including DNA-binding site isolation, luciferase reporter transcriptional repression assays, dimerization domain mapping by deletion analysis, and characterization of alternative splice isoforms The Journal of biological chemistry High 12692134
2006 FOXP1 is required for early B cell development; its absence causes a block in the pro-B to pre-B cell transition with decreased expression of RAG1 and RAG2. FOXP1 binds the Erag enhancer and controls V(D)J recombination of the immunoglobulin heavy chain gene in a B cell lineage-specific manner. Foxp1 knockout mouse model, gene expression profiling of B220+ fetal liver cells, chromatin immunoprecipitation (ChIP) at the Erag enhancer Nature immunology High 16819554
2004 Foxp1 is required for cardiac outflow tract septation, endocardial cushion morphogenesis, and myocardial maturation and proliferation. In Foxp1 null embryos, Sox4 expression in the outflow tract and cushions is significantly reduced, and cushion remodeling is disrupted (reduced apoptosis and persistent Nfatc1 expression in cushion mesenchyme). Gene targeting/knockout in embryonic stem cells, histological and molecular analysis of Foxp1 mutant embryos, expression analysis of Sox4 and Nfatc1 Development (Cambridge, England) High 15342473
2007 Foxp1 and Foxp2 cooperatively regulate lung alveolarization and esophageal muscle development. T1alpha (a lung alveolar epithelial type 1 cell gene) is a direct transcriptional target of both Foxp1 and Foxp2. Loss of a single Foxp1 allele in Foxp2-null mice exacerbates lung defects and compromises N-myc and Hop expression. In vitro transcriptional assays, in vivo mouse genetics (Foxp2-/- and Foxp2-/-;Foxp1+/- compound mutants), expression analysis of T1alpha, N-myc, and Hop Development (Cambridge, England) High 17428829
2010 Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and non-cell-autonomous mechanisms. In the endocardium, Foxp1 represses Sox17 and thereby promotes Fgf3/Fgf16/Fgf17/Fgf20 expression; loss of endocardial Foxp1 reduces cardiomyocyte proliferation rescued by exogenous Fgf20. In the myocardium, Foxp1 directly represses Nkx2.5; loss of myocardial Foxp1 increases cardiomyocyte proliferation and decreased differentiation, and Nkx2.5 transgenic overexpression phenocopies this. Conditional (endocardium- and myocardium-specific) Foxp1 knockout mice, Fgf20 rescue experiment, Nkx2.5 transgenic overexpression, direct target identification Genes & development High 20713518
2011 Foxp1 maintains naive CD8+ T cell quiescence by repressing IL-7Rα expression (by antagonizing Foxo1) and negatively regulating MEK and Erk signaling. Acute deletion of Foxp1 causes naive T cells to gain effector phenotype and proliferate directly in response to IL-7 in vitro and in lympho-replete and MHC class I-deficient mice. Conditional and acute Foxp1 deletion in T cells, in vitro IL-7 stimulation assays, gene expression analysis, adoptive transfer into lymphopenic mice Nature immunology High 21532575
2012 Foxp1 and Foxp4 cooperatively restrict goblet cell fate in lung secretory epithelium by directly repressing anterior gradient 2 (Agr2). Loss of Foxp1/4 leads to ectopic goblet cell differentiation, and forced Agr2 expression is sufficient to promote goblet cell fate. Conditional Foxp1/4 double knockout in lung epithelium, gain-of-function Agr2 overexpression, gene expression and histological analysis Development (Cambridge, England) High 22675208
2013 Foxp1 maintains hair follicle stem cell quiescence by directly regulating Fgf18 expression. Loss of Foxp1 in skin epithelial cells causes premature stem cell activation; overexpression promotes cell cycle arrest. Exogenous FGF18 rescues premature stem cell activation in Foxp1-null mice. Conditional Foxp1 knockout in skin epithelium, Foxp1 overexpression in keratinocytes, exogenous FGF18 rescue experiment, gain- and loss-of-function studies Development (Cambridge, England) High 23946441
2014 Brain-specific Foxp1 deletion causes pronounced disruption of striatal development, abnormal CA1 hippocampal neuronal morphogenesis with reduced excitability and imbalance of excitatory/inhibitory input, and autistic-like behavioral deficits. Nestin-Cre brain-specific Foxp1 knockout mice, electrophysiology of CA1 neurons, behavioral testing Molecular psychiatry High 25266127
2014 Foxp1/2/4 proteins interact with Runx2 both in vitro and in vivo and repress Runx2 transactivation function, establishing them as a suppresser complex coordinating osteogenesis and chondrocyte hypertrophy during endochondral ossification. In vitro and in vivo protein interaction assays (co-IP), heterologous transcriptional repression assays, loss- and gain-of-function mouse genetics Developmental biology High 25527076
2015 FOXP1 directly represses expression of PRDM1, IRF4, and XBP1 (master regulators of plasma cell differentiation) in primary human memory B cells, establishing FOXP1 as a transcriptional repressor of plasma cell differentiation. Constitutive FOXP1 overexpression blocks plasma cell differentiation. Ectopic FOXP1 overexpression in primary human memory B cells and B-cell lines, gene expression profiling, ChIP-sequencing Blood High 26289642
2015 FOXP1 potentiates Wnt/β-catenin signaling in DLBCL by forming a complex with β-catenin, TCF7L2, and the acetyltransferase CBP on promoters of Wnt target genes. FOXP1 promotes CBP-mediated acetylation of β-catenin, which is required for FOXP1-mediated potentiation of β-catenin-dependent transcription. Genome-wide mass spectrometry-coupled gain-of-function genetic screen, co-immunoprecipitation, ChIP at Wnt target promoters, acetylation assays, zebrafish gain/loss-of-function, xenograft tumor models Science signaling High 25650440
2015 FoxP1 regulates striatal medium spiny neuron excitability and ASD-relevant signaling pathways in the striatum, and FoxP1 reduction correlates with defects in ultrasonic vocalizations. FoxP1 has an evolutionarily conserved role in regulating striatal neuron identity pathways in human neural progenitors. Heterozygous Foxp1 mouse model, single-cell electrophysiology, gene expression profiling in mouse brains and human neural progenitors with altered FOXP1 levels Genes & development High 26494785
2016 FOXP1 directly represses S1PR2 in DLBCL cell lines, and this repression promotes tumor cell survival; ectopic S1PR2 expression induces apoptosis via Gα13 but independently of AKT signaling. ChIP combined with gene expression profiling after FOXP1 depletion, ectopic S1PR2 expression, S1PR2 point mutant incapable of downstream signaling, subcutaneous and orthotopic tumor models Blood High 26729899
2016 Foxp1 directly binds the regulatory region of Bcl2l1 (encoding Bcl-xl) in mature B cells, and Foxp1 deficiency leads to reduced Bcl-xl expression and impaired B cell survival. Transgenic Bcl2 overexpression rescues the survival defect in Foxp1-deficient mature B cells in vivo. Conditional Foxp1 knockout in B cells, transcriptional analysis, ChIP at Bcl2l1 regulatory region, Bcl2 transgenic rescue experiment Proceedings of the National Academy of Sciences of the United States of America High 29507226
2017 FOXP1 regulates MSC cell-fate choice through interactions with the CEBPβ/δ complex and RBPjκ (key modulators of adipogenesis and osteogenesis, respectively), and directly represses p16INK4A transcription. Loss of p16INK4A in Foxp1-deficient MSCs partially rescues replication capacity and bone mass accrual. Conditional Foxp1 depletion in bone marrow MSCs, promoter occupancy analyses (ChIP), interaction studies with CEBPβ/δ and RBPjκ, p16INK4A genetic rescue The Journal of clinical investigation High 28240601
2017 FOXP1 directly represses Jagged1 expression in embryonic neural stem cells (NSCs), thereby inhibiting Notch signaling and promoting neuronal differentiation. FOXP1 knockdown reduces NSC differentiation and migration in vivo, and Jagged1 blockade rescues neuronal differentiation in FOXP1-knockdown NSCs. RNA-seq and ChIP-seq in neural stem cells, FOXP1 knockdown in utero, NSC transplantation in neonatal mice, Jagged1 rescue experiment Stem cell reports High 29141232
2017 FOXP1 acts as a negative regulator of TH9 cell differentiation and IL-9 production. In naive CD4+ T cells, FOXP1 binds the Il9 promoter and inhibits Il9 expression; upon IL-7 stimulation, Foxo1 outcompetes FOXP1 for Il9 promoter binding and FOXP1 translocates to the cytoplasm. Foxp1 deficiency in CD4+ T cells markedly increases IL-9 production. Foxp1-deficient CD4+ T cell analysis, ChIP at Il9 promoter (Foxp1 and Foxo1), forced expression and deficiency experiments, IL-7 stimulation Science signaling High 29018172
2017 PUMILIO proteins (PUM1/2) directly bind two canonical PUM responsive elements in the FOXP1 3'UTR and promote FOXP1 expression (contrary to canonical PUM repressive activity), sustaining HSPC proliferation and leukemic cell growth. FOXP1 in turn represses p21-CIP1 and p27-KIP1 cell cycle inhibitors. shRNA screen, proteomic identification of FOXP1 as PUM1/2 target, direct binding to FOXP1 3'UTR, FOXP1 overexpression/knockdown, cell cycle inhibitor expression analysis Blood High 28232582
2019 Foxp1 in regulatory T cells markedly increases Foxp3 binding at a large number of genomic sites co-occupied by both factors. Foxp1 deficiency in Treg cells impairs their function and fitness, reducing CD25/IL-2Rα expression and IL-2 responsiveness and diminishing CTLA-4 expression. IL-2 signaling rescues some of these defects. Foxp1 conditional KO in Treg cells, genome-wide ChIP analysis of Foxp3 and Foxp1 binding, flow cytometric analysis, IL-2 signaling rescue experiments Nature immunology High 30643266
2019 Endothelial Foxp1 suppresses atherosclerosis by directly repressing Nlrp3, caspase-1, and IL-1β inflammasome components. Oscillatory shear stress downregulates Foxp1 via repression of Klf2, and Foxp1 is regulated as a direct target of Klf2 in endothelial cells. Endothelial-specific Foxp1 KO and transgenic overexpression mice on ApoE-KO background, atherosclerosis lesion quantification, in vitro inflammasome component regulation, KLF2-FOXP1 regulatory relationship studies Circulation research High 31318658
2019 Foxp1 controls brown/beige adipocyte differentiation and thermogenesis by directly repressing β3-adrenergic receptor (β3-AR) transcription and regulating its desensitization. Adipose-specific Foxp1 deletion increases brown adipose activity and browning of white adipose tissue, protecting from diet-induced obesity. Adipose-specific Foxp1 conditional KO, Foxp1 overexpression in adipocytes, direct transcriptional repression of β3-AR, energy expenditure measurements, diet-induced obesity model Nature communications High 31699980
2019 Foxp1 binds the conserved noncoding sequence 2 (CNS2) element of the Foxp3 locus, helping to stabilize Foxp3 expression and maintain Treg suppressive function. Foxp1 and Foxp3 coordinately regulate CTLA-4 expression levels. Conditional Foxp1 deletion in Treg cells, ChIP at Foxp3 CNS2, Foxp3 expression stability analysis, CTLA-4 expression assays PLoS biology High 31125332
2010 FoxP1 promotes midbrain dopamine neuron identity by directly regulating Pitx3. FoxP1 binds two high-affinity sites in the distal Pitx3 promoter (demonstrated by ChIP and EMSA) and activates Pitx3 promoter activity. Forced FoxP1 expression in embryonic stem cells induces Pitx3 expression. Forced FoxP1 expression in ES cells, dual-luciferase reporter assay, ChIP, electrophoretic mobility shift assay (EMSA) at Pitx3 promoter Journal of neurochemistry High 20175877
2009 Foxp1 directly represses Lhx3 transcription in spinal cord neurons by binding a consensus motif in the Lhx3 promoter. Foxp1 overexpression markedly attenuates endogenous Lhx3 expression. Foxp1(high) neurons in the spinal cord are lateral motor column motor neurons (Islet2+/Lhx3-); Foxp1(low) neurons are V1 interneurons. Chromatin immunoprecipitation in neuronal cell lines and E13.5 spinal cords, overexpression in a neuroendocrine cell line, immunohistochemical mapping Developmental neuroscience High 19797899
2014 FOXP1, FOXP2, and FOXP4 form homo- and heterodimers and the specific combination of dimers differentially regulates transcription of FOXP2 target genes (CER1, SFRP4, WISP2, PRICKLE1, NCOR2, SNW1, NEUROD2, PAX3, EFNB3, SLIT1) involved in neuronal development. Stable transfection of FOXP1/2/4 open-reading frames into HEK293 cells, quantitative RT-PCR of target gene expression, dimerization analysis Journal of molecular neuroscience Medium 25027557
2013 FOXP1 acts as both a transcriptional activator and repressor of genes involved in the germinal center reaction in B cells; approximately half of its targets are also BCL6 targets. Aberrant FOXP1 expression in transgenic mice impairs germinal center formation, reduces GC B cells, and inhibits class switching to IgG1 by repressing noncoding γ1 germline transcripts. ChIP-on-chip and gene expression assays on B cells, FOXP1 transgenic mice, GC analysis, class switching assays Blood High 23580662
2016 FOXP1 overexpression increases promoter activity of ABCG2, OCT4, NANOG, and SOX2 in ovarian cancer cells in a FOXP1-binding-site-dependent manner, promoting cancer stem cell-like characteristics including spheroid formation, EMT gene expression, and drug resistance. Knockdown and overexpression of FOXP1 in ovarian cancer cell lines, promoter activity assays (luciferase) with FOXP1-binding site deletion, xenograft mouse model Oncotarget Medium 26654944
2017 ATG14 is a direct transcriptional target of FOXP1, confirmed by ChIP assay; FOXP1 transactivates ATG14 to promote autophagy. miR-29c-3p targets FOXP1 (confirmed by luciferase reporter assay) and thereby controls the miR-29c-3p/FOXP1/ATG14 axis regulating autophagy and cisplatin resistance. ChIP assay for FOXP1 binding at ATG14 promoter, luciferase reporter assay for miR-29c-3p targeting FOXP1 3'UTR, overexpression/KD in drug-resistant ovarian cancer cells Cell cycle Medium 31885310
2021 FOXP1 acts as a repressor of P21 and RB transcription, and directly interacts with tumor suppressor p53 to inhibit its activity. ERK/JNK signaling and c-JUN/c-FOS transcription factors function as upstream activators of FOXP1 in osteosarcoma. FOXP1 overexpression and knockdown in osteosarcoma cells, direct p53 interaction assay (co-IP implied), transcriptional repression assays for P21 and RB, xenograft models with shRNA delivery Oncogene Medium 33716296
2020 Foxp1 regulates the cellular composition, neurochemical architecture, and connectivity of the striatum in a cell-type-dependent manner, as revealed by single-cell RNA-seq analysis of early postnatal striatum from Foxp1 knockout mice. Single-cell RNA sequencing of early postnatal striatum from Foxp1 conditional KO mice, cell-type-specific target gene identification Cell reports High 32130906
2020 Foxp1 maintains apical radial glia (aRG) identity and promotes deep-layer neurogenesis and self-renewing divisions in the developing neocortex. Sustained Foxp1 expression preserves aRG identity and extends early neurogenesis; FOXP1 expression is also associated with basal RG formation during human corticogenesis. Foxp1 conditional KO and overexpression in mouse cortex, in utero electroporation, single-cell analysis, human cortical transcriptomics Cell reports High 32049024
2020 Intrinsically disordered regions in the DNA-binding domain of human FoxP1 facilitate domain swapping. The FoxP1 DNA-binding domain forms a domain-swapped dimer in solution, with heterogeneous and locally disordered dimeric intermediates along the dimer dissociation pathway. Single-molecule FRET, hydrogen-deuterium exchange mass spectrometry, molecular dynamics simulations Journal of molecular biology High 32735805
2017 FOXP1 is expressed in brain-specific neonatal mice is essential for normal ultrasonic vocalization (USV); Foxp1 KO pups have strongly reduced USV and lack sex-specific call rates. Androgens regulate Foxp1 expression: brain-specific androgen receptor KO mice show reduced Foxp1 expression in the striatum, and Foxp1 and androgen receptor are co-expressed in striatal medium spiny neurons. Brain-specific Foxp1 KO mice, USV recording, brain-specific androgen receptor KO mice, immunohistochemistry for co-expression, qPCR Human molecular genetics High 28204507
2022 Foxp1 haploinsufficiency in mice leads to dysregulation of mitochondrial biogenesis and dynamics genes (Foxo1, Pgc-1α, Tfam, Opa1, Drp1) in the striatum, reduced mitochondrial membrane potential and complex I activity, decreased antioxidants (Sod2, GSH), increased oxidative stress and lipid peroxidation, resulting in reduced neurite branching and motor/cognitive deficits. Foxp1+/- mouse model, mitochondrial membrane potential measurement, complex I activity assay, antioxidant and lipid peroxidation measurements, gene expression analysis Proceedings of the National Academy of Sciences of the United States of America High 35165191
2021 FoxP1 knockdown in striatal-projecting forebrain mirror neurons in zebra finches prevents juvenile birds from forming memories of an adult song model, without interrupting vocal imitation of previously memorized song. This selective memory deficit is associated with disruptions to experience-dependent structural and synaptic plasticity in mirror neurons. FoxP1 knockdown in zebra finch striatal-projecting mirror neurons, behavioral song learning paradigm, synaptic and structural plasticity analysis Science advances High 33536209
2023 FOXP1 acts as a hub transcription factor in the stem-like CD8+ T cell gene network in CAR T cells, promoting expansion and stemness while limiting effector differentiation. FOXP1 is regulated by high numbers of enhancers in stem-like T cells. Simultaneous single-cell chromatin accessibility (ATAC) and transcriptome profiling of CAR T cells, FOXP1 perturbation experiments in CAR T cells Nature immunology High 38012417
2023 FOXP1 deficiency in human embryonic stem cell-derived cardiomyocytes leads to hypertrophic and senescent phenotypes. FOXP1 is identified as a key downregulated factor in aged primate cardiomyocytes with corresponding dysregulation of FOXP1 target genes. Single-nucleus RNA-seq of cynomolgus monkey heart, FOXP1 knockdown in hESC-derived cardiomyocytes, transcription regulatory network analysis Protein & cell Medium 37084237
2024 FOXP1 inhibits CDKN1A transcription in ovarian granulosa cells; silencing FOXP1 in mice results in premature ovarian insufficiency. Single-cell RNA-seq and spatial transcriptomics of human ovaries, FOXP1 silencing in mice, CDKN1A expression analysis Nature aging Medium 38594460
2023 NAT10-catalyzed ac4C modification of FOXP1 mRNA enhances its translation efficiency in cervical cancer. FOXP1 in turn induces GLUT4 and KHK expression, driving glycolysis and lactic acid secretion that amplifies immunosuppression by tumor-infiltrating Tregs. HOXC8 activates NAT10 by binding its promoter. NAT10 knockdown, ac4C modification detection of FOXP1 mRNA, FOXP1 overexpression/knockdown, GLUT4/KHK expression analysis, in vivo tumor model with PD-L1 blockade Advanced science Medium 37818745
2016 In ABC-DLBCL, sustained FOXP1 expression is vital for cell survival; FOXP1 transcriptionally enforces classical NF-κB and MYD88 pathways and promotes plasmablast-stage gene expression programs while antagonizing BCL6-dependent GCB pathways. Genome-wide ChIP analysis, gene expression profiling after FOXP1 depletion, DLBCL subtype transcriptional analysis, cell-line survival assays Proceedings of the National Academy of Sciences of the United States of America High 26787899
2017 Foxp1 directly represses p21 (Cdkn1a) gene transcription in neurons is challenged by this paper: here, Foxp1 isoform-A activates p21 transcription (luciferase assay at p21 promoter), and p21 elevation mediates Foxp1 neuroprotection against mutant huntingtin. Foxp1 isoforms A and D are selectively reduced in striatum/cortex in HD mice and human patients. Luciferase assay at p21 promoter, Foxp1 isoform overexpression in cortical neurons, p21 knockdown epistasis, mutant Htt neurotoxicity assay The Journal of neuroscience Medium 28550168
2016 FOXP1 has protein-protein interaction with NFAT1 on DNA and represses NFAT1 transcriptional activity, enhancing MDA-MB-231 breast cancer cell migration. Co-immunoprecipitation, EMSA (protein-protein interaction on DNA), luciferase reporter assay for NFAT1 transcriptional repression, wound healing migration assay Cell biology international Medium 27859969
2019 FOXP1 overexpression in endometriotic stromal cells enhances fibrosis by activating Wnt/β-catenin signaling (increased β-catenin acetylation). FOXP1 knockdown reduces Wnt signaling and fibrotic markers, and the Wnt inhibitor AVX939 blocks β-catenin acetylation induced by ectopic FOXP1. siRNA knockdown and overexpression in endometriotic stromal cells, Western blot for β-catenin acetylation, Wnt signaling inhibitor experiment, collagen gel contraction assay American journal of translational research Medium 30662612
2022 FOXP1 upregulates SIRT1 expression post-transcriptionally by stabilizing SIRT1 protein, independent of FOXOs or superoxide dismutases. FOXP1 knockdown sensitizes AML cells to chemotherapy, and FOXP1 antioxidant activity in myeloid progenitors acts through SIRT1. FOXP1 knockdown in AML cells, SIRT1 protein stability assay, superoxide anion measurement, chemotherapy sensitivity assays Blood advances Medium 36930820
2023 Jarid2 represses Foxp1 in retinal progenitor cells via H3K27me3 histone modification at the Foxp1 locus; Foxp1 drives early retinal cell type production and represses late progenitor gene expression. Loss of Jarid2 extends Foxp1 expression and early retinal cell production, and Foxp1 is required for extended early retinal cell production after Jarid2 loss. Jarid2 knockout mouse, H3K27me3 ChIP analysis, Foxp1 gain/loss-of-function in retinal progenitors, epistasis between Jarid2 and Foxp1 Cell reports High 36924502
2021 FOXP1 directly represses S1PR2 transcription in DLBCL (established previously) and promotes tumor cell survival; Foxp1 directly binds regulatory region of Bcl2l1 in B cells controlling Bcl-xl expression (established separately). In Treg cells, Foxp1 binds Foxp3 CNS2 to stabilize Foxp3 expression. See individual entries above See individual entries above High 26729899 29507226 31125332
2021 FOXP1 directly regulates endothelial glycolysis by repressing Hif1α transcription; Hk2 is a downstream target of Hif1α. The Foxp1-Hif1α-Hk2 pathway in endothelial cells governs glycolytic metabolism and tumor angiogenesis. EC-Foxp1 deletion mice, retinal and tumor angiogenesis assays, Hif1α identified as direct Foxp1 target gene, Hk2 identified as Hif1α target, siRNA nanoparticle delivery of Hif1α/Hk2 in tumor model Redox biology Medium 39083899

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. The Journal of comparative neurology 409 12687690
2006 Foxp1 is an essential transcriptional regulator of B cell development. Nature immunology 273 16819554
2007 Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development (Cambridge, England) 239 17428829
2004 Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. The Journal of neuroscience : the official journal of the Society for Neuroscience 239 15056695
2004 Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development (Cambridge, England) 218 15342473
2003 Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. The Journal of biological chemistry 193 12692134
2011 Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nature immunology 165 21532575
2019 Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation. Circulation research 161 31318658
2017 FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging. The Journal of clinical investigation 161 28240601
2019 Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression. Molecular cancer 155 31623628
2007 FOXP1: a potential therapeutic target in cancer. Expert opinion on therapeutic targets 140 17614763
2023 NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 121 37818745
2005 FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Leukemia 119 15944719
2014 Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour. Molecular psychiatry 116 25266127
2012 The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders. Human genetics 110 22736078
2019 miR-29c-3p inhibits autophagy and cisplatin resistance in ovarian cancer by regulating FOXP1/ATG14 pathway. Cell cycle (Georgetown, Tex.) 108 31885310
2024 Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1. Nature aging 102 38594460
2010 Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes & development 99 20713518
2012 Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development (Cambridge, England) 97 22675208
2019 FOXP1 circular RNA sustains mesenchymal stem cell identity via microRNA inhibition. Nucleic acids research 93 30937446
2017 PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells. Blood 91 28232582
2015 FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes & development 87 26494785
2019 Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature immunology 84 30643266
2022 Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome. Proceedings of the National Academy of Sciences of the United States of America 73 35165191
2016 FOXP1 functions as an oncogene in promoting cancer stem cell-like characteristics in ovarian cancer cells. Oncotarget 73 26654944
2013 Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development (Cambridge, England) 73 23946441
2017 Prospective investigation of FOXP1 syndrome. Molecular autism 72 29090079
2015 FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Science signaling 70 25650440
2019 Circular RNA circ-FOXP1 induced by SOX9 promotes hepatocellular carcinoma progression via sponging miR-875-3p and miR-421. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 68 31698267
2012 High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer. American journal of clinical pathology 64 22904134
2023 FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells. Nature immunology 62 38012417
2019 Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization. Nature communications 62 31699980
2014 Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Developmental biology 62 25527076
2017 FOXP1-related intellectual disability syndrome: a recognisable entity. Journal of medical genetics 61 28735298
2017 FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression. Stem cell reports 59 29141232
2017 Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7. Science signaling 57 29018172
2013 Downregulation of FOXP1 is required during germinal center B-cell function. Blood 57 23580662
2014 Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization. Journal of molecular neuroscience : MN 55 25027557
2019 Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function. PLoS biology 53 31125332
2016 The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling. Blood 53 26729899
2018 Knockdown of LINC01614 inhibits lung adenocarcinoma cell progression by up-regulating miR-217 and down-regulating FOXP1. Journal of cellular and molecular medicine 52 29934982
2021 FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring. Journal of neurodevelopmental disorders 50 33892622
2015 Foxp1 regulates cortical radial migration and neuronal morphogenesis in developing cerebral cortex. PloS one 49 26010426
2015 The forkhead transcription factor FOXP1 represses human plasma cell differentiation. Blood 49 26289642
2020 Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates. Cell reports 48 32049024
2020 Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development. Cell reports 48 32130906
2016 The significance of FOXP1 in diffuse large B-cell lymphoma. Leukemia & lymphoma 47 27678023
2016 FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation. Experimental neurology 44 27154297
2023 Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging. Protein & cell 43 37084237
2016 Downregulation of FOXP1 Inhibits Cell Proliferation in Hepatocellular Carcinoma by Inducing G1/S Phase Cell Cycle Arrest. International journal of molecular sciences 41 27618020
2018 FOXP1 negatively regulates tumor infiltrating lymphocyte migration in human breast cancer. EBioMedicine 40 30579865
2021 FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53. Oncogene 38 33716296
2022 Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis. Journal of cachexia, sarcopenia and muscle 37 36564038
2022 Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion. Frontiers in immunology 36 36268015
2018 FOXP1 enhances fibrosis via activating Wnt/β-catenin signaling pathway in endometriosis. American journal of translational research 36 30662612
2017 Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization. Human molecular genetics 36 28204507
2021 Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling. Theranostics 33 33408770
2018 Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells. Proceedings of the National Academy of Sciences of the United States of America 33 29507226
2019 FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells. Chemico-biological interactions 30 31494106
2015 FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. Oncology letters 30 25663935
2022 LncRNA XIST promotes carboplatin resistance of ovarian cancer through activating autophagy via targeting miR-506-3p/FOXP1 axis. Journal of gynecologic oncology 29 36335987
2016 Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1. Proceedings of the National Academy of Sciences of the United States of America 29 26787899
2023 Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. Cell reports 28 36924502
2010 FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3. Journal of neurochemistry 28 20175877
2014 FOXP1 inhibits cell growth and attenuates tumorigenicity of neuroblastoma. BMC cancer 27 25406647
2018 Knockdown of FOXP1 promotes the development of lung adenocarcinoma. Cancer biology & therapy 26 30409062
2020 Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway. European review for medical and pharmacological sciences 24 32633368
2018 Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain. Neuroscience 24 30031127
2018 STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription. Journal of cellular and molecular medicine 24 30134017
2010 FOXP1 expression and its clinicopathologic significance in nodal and extranodal diffuse large B-cell lymphoma. Annals of hematology 24 21120478
2021 Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations. Science advances 23 33536209
2018 miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma. Biochemical and biophysical research communications 23 30031607
2016 Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene expression patterns : GEP 23 26969076
2016 FOXP1 enhances tumor cell migration by repression of NFAT1 transcriptional activity in MDA-MB-231 cells. Cell biology international 23 27859969
2015 Expression and significance of FOXP1, HIF-1a and VEGF in renal clear cell carcinoma. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 23 25778315
2014 Complexin-1 and Foxp1 Expression Changes Are Novel Brain Effects of Alpha-Synuclein Pathology. Molecular neurobiology 23 25112678
2023 FOXP1 regulates oxidative stress, SIRT1 expression, and resistance to chemotherapies in acute myeloid leukemia cells. Blood advances 22 36930820
2020 A novel epigenetic regulation of circFoxp1 on Foxp1 in colon cancer cells. Cell death & disease 22 32951006
2020 Elevated MicroRNA 183 Impairs Trophoblast Migration and Invasiveness by Downregulating FOXP1 Expression and Elevating GNG7 Expression during Preeclampsia. Molecular and cellular biology 22 33139493
2021 Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p. Journal of immunology research 21 34514002
2018 MiR-92a regulates oral squamous cell carcinoma (OSCC) cell growth by targeting FOXP1 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 21 29772443
2018 miR-29b inhibits the progression of multiple myeloma through downregulating FOXP1. Hematology (Amsterdam, Netherlands) 21 30068241
2021 Circular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade. Bioengineered 20 34654357
2017 Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 20 28550168
2013 FOXP1 and estrogen signaling in breast cancer. Vitamins and hormones 20 23810008
2021 CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p. Genes & genomics 18 33830472
2010 Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization. Neuroscience 18 20056137
2018 miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. European journal of immunology 17 30281154
2015 FOXP1 and SPINK1 reflect the risk of cirrhosis progression to HCC with HBV infection. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 16 26054682
2021 HMGB1/Foxp1 regulates hypoxia-induced inflammatory response in macrophages. Cell biology international 15 34816539
2020 Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping. Journal of molecular biology 15 32735805
2020 Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis. Neurochemical research 15 33095438
2014 The expression and correlation between the transcription factor FOXP1 and estrogen receptors in epithelial ovarian cancer. Biochimie 15 25500588
2009 Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis. Developmental neuroscience 15 19797899
2025 AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1. Cardiovascular diabetology 14 40205587
2024 Therapeutic efficacy of ECs Foxp1 targeting Hif1α-Hk2 glycolysis signal to restrict angiogenesis. Redox biology 14 39083899
2021 The circACC1/miR-29c-3p/FOXP1 network plays a key role in gastric cancer by regulating cell proliferation. Biochemical and biophysical research communications 14 33887587
2020 CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6. Aging 14 32584787
2014 Differential FoxP2 and FoxP1 expression in a vocal learning nucleus of the developing budgerigar. Developmental neurobiology 13 25407828
2007 Molecular cloning, characterization, and developmental expression of foxp1 in zebrafish. Development genes and evolution 13 17876603

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