Affinage

FBXO2

F-box only protein 2 · UniProt Q9UK22

Length
296 aa
Mass
33.3 kDa
Annotated
2026-06-09
40 papers in source corpus 28 papers cited in narrative 28 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FBXO2 is a neuronally enriched F-box protein that serves as the substrate-recognition subunit of an SCF (SKP1-CUL1-RBX1) E3 ubiquitin ligase, recruiting substrates through its F-box-dependent association with Skp1 and selectively engaging high-mannose N-glycans on glycoprotein targets via its FBA/sugar-binding domain (PMID:9857061, PMID:34515398). Through this glycan-recognition activity it directs a broad set of glycoproteins to ubiquitin-mediated proteasomal degradation, including the insulin receptor, where SCF-FBXO2 activity tunes systemic glucose homeostasis (PMID:27932386), NMDAR subunits GluN1 and GluN2A controlling synaptic receptor surface levels (PMID:25878288), and the amyloid precursor protein (PMID:24469452). The same glycan-sensing capacity underlies cell-autonomous innate defense: FBXO2 marks N-glycosylated EBV glycoprotein B for degradation to restrict viral entry (PMID:30052682) and, as part of the SCF complex, recognizes GlcNAc moieties on the group A Streptococcus surface and on damaged lysosomal membranes to drive ubiquitin-dependent xenophagy and CNS lysophagy (PMID:34515398, PMID:32931479). In multiple epithelial cancers FBXO2 acts as a degradative hub through its FBA domain, ubiquitinating substrates such as SUN2, WEE1, USP49, YTHDF2, and KPTN, the last of which disrupts KICSTOR assembly and GATOR1 recruitment to activate amino acid-dependent mTORC1 signaling (PMID:35525855, PMID:40676478, PMID:41401028). In the cochlea, FBXO2 and Skp1 instead form a heterodimer distinct from the canonical SCF complex that is required for cochlear support-cell survival, and FBXO2 loss causes selective cochlear degeneration in mice (PMID:17494702). FBXO2 expression is itself controlled transcriptionally and post-transcriptionally, and the protein additionally engages substrates through non-proteasomal routes including autophagy and chaperone-mediated lysosomal degradation (PMID:26295339, PMID:41604941).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1998 Medium

    Established FBXO2 as a bona fide F-box protein that physically couples to the ubiquitin-proteasome machinery, defining its core biochemical identity.

    Evidence Co-IP and F-box deletion mutagenesis with cell proliferation readout in neuroblastoma and CHO cells

    PMID:9857061

    Open questions at the time
    • No substrate identified at this stage
    • Did not establish glycan-recognition specificity
    • Assembly into full SCF not yet shown
  2. 2004 Medium

    Showed FBXO2 recognizes specific glycoprotein substrates and can form complexes beyond the canonical SCF, first hinting at its tissue-specialized role in the cochlea.

    Evidence EMSA, in vitro pulldown, sedimentation equilibrium, and Co-IP from organ of Corti for connexin 26 and Skp1 binding

    PMID:11470190 PMID:15109709

    Open questions at the time
    • Did not demonstrate ubiquitination/degradation of Cx26 in vivo
    • Functional consequence of binding unresolved
  3. 2004 Medium

    Demonstrated that FBXO2 can be redirected to the nucleus and degrade a viral replication initiator, linking it to antiviral control in neurons.

    Evidence Live-cell imaging of nuclear shuttling, Co-IP, and proteasome inhibitor rescue of UL9 in 293T cells and primary hippocampal neurons

    PMID:12904574 PMID:15010529

    Open questions at the time
    • Physiological contribution to HSV-1 latency not directly tested
    • Signal triggering nuclear shuttling unknown
  4. 2007 Medium

    Resolved that cochlear FBXO2 functions in a non-canonical Skp1 heterodimer rather than full SCF, and that this complex is essential for cochlear cell survival.

    Evidence Fbxo2 knockout mice with Co-IP, western blot, and histology of the organ of Corti

    PMID:17494702

    Open questions at the time
    • Mechanism by which the heterodimer protects support cells unclear
    • Relevant degradation substrate in cochlea not defined
  5. 2015 Medium

    Connected FBXO2 to neuronal and ER-quality-control glycoprotein homeostasis, establishing it as a regulator of synaptic receptor surface levels and misfolded-protein clearance.

    Evidence Fbxo2 knockout mice and cultured neurons with surface biotinylation and electrophysiology (GluN1/GluN2A, APP); cycloheximide chase and knockdown for A1AT-Z in hepatic cells/mice

    PMID:24469452 PMID:25878288 PMID:26295339

    Open questions at the time
    • Selectivity for GluN2A over GluN2B not mechanistically explained
    • Relative use of proteasomal vs autophagic routes substrate-dependent and incompletely defined
  6. 2016 High

    Identified FBXO2 as an SCF E3 controlling metabolic and disease-relevant glycoproteins, demonstrating in vivo physiological consequence.

    Evidence LC-MS/MS substrate screening with in vivo gain/loss-of-function for the insulin receptor; siRNA and Cl- transport assays for ΔF508-CFTR in primary airway epithelia

    PMID:27756846 PMID:27932386

    Open questions at the time
    • Whether IR degradation is direct via glycan recognition vs indirect not fully separated for CFTR
    • CFTR involvement via a complex distinct from SYVN1 not structurally characterized
  7. 2018 High

    Mapped substrate recognition to the FBA sugar-binding domain engaging high-mannose N-glycans, providing the molecular basis for FBXO2 antiviral restriction.

    Evidence Co-IP, ubiquitination, and viral fusion/entry assays for EBV glycoprotein B via the sugar-binding domain

    PMID:30052682

    Open questions at the time
    • Generality of high-mannose preference across all substrates not exhaustively tested
  8. 2021 High

    Generalized FBXO2 glycan-sensing to innate immunity, showing it tags non-self and damaged-self carbohydrate surfaces for selective autophagy.

    Evidence FBXO2 knockout cells with ubiquitin-accumulation and bacterial clearance assays and sugar-binding mutants for GAS xenophagy; primary neuron and NPC mouse models for CNS lysophagy with SCF components required

    PMID:32931479 PMID:34515398

    Open questions at the time
    • Adaptor linking ubiquitinated targets to autophagic machinery not defined
    • How a cytoplasmic glycoprotein-glycan ligase accesses luminal/surface glycans mechanistically open
  9. 2025 Medium

    Defined FBXO2 as a broad oncogenic and signaling degradative hub acting through its FBA/C-terminal regions on diverse substrates with site- and linkage-specific ubiquitination.

    Evidence Co-IP/MS, domain mapping, site-directed mutagenesis, linkage-specific ubiquitination, and xenograft/in vivo models for KPTN, WEE1, USP49, YTHDF2, SUN2, NR2F2, LCN2, FABP5, and IL6ST

    PMID:35525855 PMID:40676478 PMID:40791152 PMID:41035649 PMID:41076860 PMID:41401028 PMID:41436429 PMID:41461633 PMID:41604941

    Open questions at the time
    • Many substrates validated in single tumor contexts without cross-validation
    • Determinants choosing K48 vs K63 vs K27 vs autophagic fate per substrate unresolved
    • Whether all substrates require glycan recognition not uniformly established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FBXO2 substrate selection is governed across its many reported targets and how it switches between SCF-dependent proteasomal degradation, autophagy/lysophagy, and non-degradative roles remains unresolved.
  • No unifying structural model of glycan vs non-glycan substrate recognition
  • Regulation of complex composition (canonical SCF vs Skp1 heterodimer) across tissues unclear
  • Physiological hierarchy among the large substrate set not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0060090 molecular adaptor activity 3 GO:0016874 ligase activity 2
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-9612973 Autophagy 3 R-HSA-168256 Immune System 2
Partners
APC2CUL1KPTNRBX1SKP1SUN2USP49WEE1
Complex memberships
FBXO2-Skp1 cochlear heterodimerSCF (SKP1-CUL1-RBX1) E3 ubiquitin ligase

Evidence

Reading pass · 28 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 FBXO2 (NFB42) contains an F-box domain that mediates interaction with Skp1p, a component of the ubiquitin-proteasome pathway; deletion of the F-box abolishes both Skp1p interaction and the growth-inhibitory effect of NFB42 overexpression in neuroblastoma and CHO cells. Co-immunoprecipitation, F-box deletion mutagenesis, cell proliferation assay The Journal of biological chemistry Medium 9857061
2001 OCP1 (FBXO2) co-localizes with OCP2 (Skp1) in the epithelial gap-junction region of the cochlear organ of Corti, consistent with formation of an SCF ubiquitin ligase complex at this site. Immunohistochemistry, sequence analysis Hearing research Low 11470190
2003 NFB42 (FBXO2) binds the phosphorylated HSV-1 replication-initiator protein UL9, promoting its polyubiquitination and degradation via the 26S proteasome; MG132 treatment restores UL9 levels, confirming proteasomal mechanism. Co-expression in 293T cells, proteasome inhibitor (MG132) rescue, in vivo polyubiquitination assay Proceedings of the National Academy of Sciences of the United States of America Medium 12904574
2004 HSV-1 infection induces nuclear shuttling of NFB42 (FBXO2), allowing it to bind nuclear phosphorylated UL9, export UL9 to the cytoplasm, and mediate its ubiquitination and proteasomal degradation, thereby potentially promoting viral latency in neurons. Live-cell imaging of NFB42 nuclear shuttling, co-immunoprecipitation of NFB42-UL9, proteasome inhibitor rescue in 293T cells and primary hippocampal neurons Proceedings of the National Academy of Sciences of the United States of America Medium 15010529
2004 OCP1 (FBXO2) forms a heterodimeric complex with OCP2 (Skp1) in the organ of Corti, and directly binds connexin 26 (Cx26) as shown by electrophoretic mobility-shift, in vitro pulldown with 35S-labeled Cx26, and co-immunoprecipitation from organ of Corti extracts. Electrophoretic mobility-shift assay, pulldown with immobilized OCP1, sedimentation equilibrium, co-immunoprecipitation from tissue extracts Hearing research Medium 15109709
2007 Cochlear FBXO2 binds Skp1 to form a novel heterodimeric complex distinct from the canonical SCF complex (Cullin1 and Rbx1 show little association with Fbx2/Skp1 in the cochlea); loss of Fbxo2 in knockout mice leads to parallel loss of cochlear Skp1 levels and selective cochlear degeneration beginning in epithelial support cells. Targeted gene knockout, co-immunoprecipitation, western blot, histology The Journal of neuroscience : the official journal of the Society for Neuroscience Medium 17494702
2010 FBG1 (FBXO2) directly interacts with APC2 via a D-box motif within its F-box domain; co-expression sequesters free APC2 (raising total but lowering free APC2), inhibiting cell proliferation and inducing S-phase arrest independent of its ubiquitin ligase function. Co-immunoprecipitation, D-box mutagenesis, FACS cell cycle analysis, western blot Cell cycle (Georgetown, Tex.) Medium 21135578
2014 FBXO2 targets APP (amyloid precursor protein), a high-mannose glycoprotein, for ubiquitin-mediated degradation; loss of Fbxo2 in knockout mice and cultured hippocampal neurons increases APP levels and processing into cleavage products, with a concomitant reduction of APP at the cell surface. Fbxo2 knockout mice, cultured hippocampal neurons/slices, western blot, cell surface biotinylation, non-neuronal cell overexpression The Journal of biological chemistry Medium 24469452
2015 Fbxo2 regulates GluN1 and GluN2A (but not GluN2B) NMDAR subunit levels and surface localization in the adult mouse brain; loss of Fbxo2 increases surface GluN1 and GluN2A, elevates synaptic markers PSD-95 and Vglut1, and promotes aberrant axo-dendritic shaft synapses without altering spine density or neurophysiology. Fbxo2 knockout mice, western blot, surface biotinylation, immunofluorescence, electrophysiology, confocal microscopy The Journal of neuroscience : the official journal of the Society for Neuroscience Medium 25878288
2015 FBG1 (FBXO2) degrades the misfolded glycoprotein A1AT-Z through both the ubiquitin-proteasome system and Beclin1-dependent autophagy; overexpression decreases A1AT-Z half-life and knockdown in hepatic cells and mice increases A1AT-Z accumulation. Chemical inhibitors, genetic knockdown/overexpression, cycloheximide chase, Beclin1 co-dependency assay in hepatic cell lines and mouse liver PloS one Medium 26295339
2016 SCFFBXO2 acts as an E3 ubiquitin ligase that targets the insulin receptor (IR) for ubiquitin-dependent proteasomal degradation; overexpression of FBXO2 in healthy mice causes hyperglycemia and insulin resistance, while ablation in obese mice alleviates diabetic phenotypes. Protein purification combined with LC-MS/MS substrate screening, adenovirus-mediated overexpression in mice, Fbxo2 knockout in obese mouse model, glucose tolerance and insulin tolerance tests Diabetes High 27932386
2016 FBXO2 knockdown partially restores ΔF508-CFTR-mediated Cl⁻ transport in primary human cystic fibrosis airway epithelia, indicating FBXO2 participates in ubiquitin-mediated proteasomal degradation of ΔF508-CFTR via a distinct complex from SYVN1. siRNA knockdown, functional CFTR Cl⁻ transport assay in polarized primary airway epithelia, CFTR maturation assay The Journal of biological chemistry Medium 27756846
2018 FBXO2 directly binds N-glycosylated (high-mannose) EBV glycoprotein B (gB) through its sugar-binding domain, promoting gB ubiquitination and proteasomal degradation; FBXO2 depletion stabilizes gB, promotes its transport from ER to plasma membrane, and enhances viral membrane fusion and entry. Co-immunoprecipitation, knockdown/overexpression, ubiquitination assay, membrane fusion assay, viral infectivity assay PLoS pathogens High 30052682
2020 Fbxo2 functions as a component of the SCF ubiquitin ligase complex to mediate CNS lysophagy: loss of Fbxo2 in mouse primary cortical cultures delays clearance of damaged lysosomes and decreases viability after lysosomal damage; Fbxo2 deficiency in a NPC mouse model exacerbates motor deficits, neurodegeneration, and reduces survival. Primary cortical neuron cultures from Fbxo2 knockout mice, lysosomal damage assay, NPC mouse model with Fbxo2 deficiency, behavioral testing, histology JCI insight Medium 32931479
2020 FBXO2 targets glycosylated fibrillin-1 (FBN1) for ubiquitin-dependent proteasomal degradation to promote endometrial cancer cell proliferation, acting through regulation of cell cycle proteins (CDK4, CyclinD1/D2/A1) and autophagy pathway components (ATG4A/4D). Ubiquitination-proteome approach to identify substrates, ubiquitination assay, RNA-seq, knockdown/overexpression, xenograft mouse model Frontiers in cell and developmental biology Medium 32984335
2020 FBXO2 promotes osteosarcoma proliferation by targeting IL-6 receptor (IL-6R) for ubiquitin-mediated degradation, thereby activating STAT3 phosphorylation and downstream gene expression; this function requires FBXO2's glycoprotein recognition activity. CRISPR-Cas9 knockout, retrovirus overexpression, co-immunoprecipitation, luciferase reporter assay for STAT3 transcriptional activity, xenograft mouse model Cancer cell international Medium 32549792
2021 FBXO2/SCF ubiquitin ligase complex recognizes GlcNAc side chains of the group A Streptococcus (GAS) surface carbohydrate through FBXO2's sugar-binding motif, promoting ubiquitin-mediated xenophagy; FBXO2 knockout reduces ubiquitin accumulation on intracellular GAS and decreases xenophagic bacterial degradation; SKP1, CUL1, and ROC1 (other SCF components) are also required. FBXO2 knockout cell lines, ubiquitin accumulation assay on intracellular GAS, xenophagy/bacterial clearance assay, sugar-binding domain mutant analysis EMBO reports High 34515398
2022 FBXO2 directly interacts with glycosylated SUN2 and promotes its ubiquitin-dependent proteasomal degradation; the SOX6 transcription factor promotes FBXO2 expression by binding its promoter, establishing a SOX6-FBXO2-SUN2 axis in ovarian cancer. Co-immunoprecipitation, ubiquitination assay, knockdown/overexpression, promoter reporter assay, xenograft mouse model Cell death & disease Medium 35525855
2023 RBM47 binds FBXO2 mRNA and stabilizes it post-transcriptionally to promote STAT3 phosphorylation and downstream signaling in chondrocytes; FBXO2 overexpression reverses the alleviating effects of RBM47 knockdown on IL-1β-induced inflammation and ECM degradation. RBM47 RNA-binding assay, FBXO2 mRNA stability assay, STAT3 phosphorylation western blot, rescue experiment with FBXO2 overexpression Biochemical genetics Low 38070024
2024 FBXO2 directly binds p53 and promotes its ubiquitination and proteasomal degradation in papillary thyroid carcinoma; p53 knockdown partially reverses the anti-proliferative effects of FBXO2 knockdown, confirming functional epistasis. Co-immunoprecipitation, in vivo ubiquitination assay, rescue epistasis experiment, subcutaneous xenograft Scientific reports Medium 39343799
2025 FBXO2 binds lipocalin-2 (LCN2) via its FBA domain and promotes K27-linked polyubiquitination of LCN2, driving its proteasomal degradation; this suppresses ferroptosis (lipid peroxidation, glutathione depletion, iron overload) and activates PINK1/Parkin-dependent mitophagy in nucleus pulposus cells; AAV9-mediated FBXO2 overexpression ameliorates intervertebral disc degeneration in rats. Co-immunoprecipitation, ubiquitination assay, FBA domain mapping, proteomics, FBXO2 KO mice, AAV9 overexpression in rats, mitochondrial functional assays Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 40791152
2025 FBXO2 colocalizes and directly interacts with KPTN (a KICSTOR complex subunit) via its F-box-associated (FBA) domain, promoting K48- and K63-linked polyubiquitination of KPTN at K49, K67, K262, and K265; this disrupts KICSTOR assembly, impairs GATOR1 lysosomal recruitment, and activates amino acid-dependent mTORC1 signaling. Co-immunoprecipitation, ubiquitination assay with linkage-specific antibodies, site-directed mutagenesis of KPTN ubiquitination sites, co-localization imaging, mTORC1 activity assays The Journal of clinical investigation High 41401028
2025 Fbxo2 binds the kinase domain of WEE1 via its FBA domain and promotes WEE1 ubiquitination and proteasomal degradation; Fbxo2 knockdown increases RCC cell motility and proliferation, and WEE1 depletion partially rescues the tumorigenic effects of Fbxo2 silencing in xenograft models. Co-immunoprecipitation, mass spectrometry, ubiquitination assay, FBA domain mutant, xenograft mouse model, rescue epistasis Cellular oncology (Dordrecht, Netherlands) Medium 40676478
2025 FBXO2 directly binds USP49 and targets it for ubiquitin-mediated proteasomal degradation in hepatocellular carcinoma; USP49 knockdown reverses the inhibitory effects of FBXO2 knockdown, confirming the FBXO2/USP49 axis; FBXO2 depletion enhances sorafenib sensitivity. Co-immunoprecipitation, in vivo ubiquitination assay, cycloheximide chase, rescue epistasis, xenograft sorafenib treatment Frontiers in immunology Medium 41035649
2025 Fbxo2 targets the m6A reader YTHDF2 for ubiquitin-mediated proteasomal degradation in prostate cancer; the C-terminal region of Fbxo2 is required for YTHDF2 ubiquitination; K286 of YTHDF2 is the key ubiquitination site; YTHDF2 promotes PCa progression by modulating m6A methylation of CDKN1C mRNA. Co-immunoprecipitation mass spectrometry, Co-IP, ubiquitination assay, site-directed mutagenesis (K286), rescue experiments, in vivo xenograft Cell death & disease Medium 41461633
2025 FUT2 scaffolds FBXO2 to facilitate K362 site-specific ubiquitination and proteasomal degradation of transcription factor NR2F2; NR2F2 degradation suppresses LCN2 expression and thereby reduces CD8+ T cell exhaustion in pancreatic cancer. In vivo CRISPR-Cas9 screen, co-immunoprecipitation, ubiquitination assay with site-specific mapping (K362), NR2F2 transcriptional reporter, tumor immune profiling Cell death & disease Medium 41436429
2025 FBXO2 interacts with FABP5 and promotes its lysosomal degradation through chaperone-mediated autophagy (not proteasomal), reducing intracellular polyunsaturated fatty acid (PUFA) levels and conferring resistance to ferroptosis in colorectal cancer; this is downstream of p53 transcriptional induction of FBXO2. Co-immunoprecipitation, FBXO2 overexpression/knockdown, lipid peroxidation and cell death assays, fatty acid supplementation rescue, in vivo tumor models Redox biology Medium 41604941
2025 FBXO2 promotes K63-linked ubiquitination of IL6ST (glycoprotein 130) to restore STAT3 signaling during decidualization; cadmium exposure downregulates FBXO2 and suppresses this IL6ST/STAT3 axis, impairing decidualization. Proteomic analysis, co-immunoprecipitation, ubiquitination assay (K63-linkage specific), FBXO2 overexpression rescue, in vivo Cd-exposed mouse model Ecotoxicology and environmental safety Medium 41076860

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience 65 17494702
1998 A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest. The Journal of biological chemistry 60 9857061
2022 FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development. Cell death & disease 44 35525855
2020 Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. JCI insight 40 32931479
2015 Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 25878288
2004 The cochlear F-box protein OCP1 associates with OCP2 and connexin 26. Hearing research 39 15109709
2018 Epstein-Barr virus activates F-box protein FBXO2 to limit viral infectivity by targeting glycoprotein B for degradation. PLoS pathogens 36 30052682
2016 Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 36 27932386
2014 F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing. The Journal of biological chemistry 32 24469452
2016 SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation. The Journal of biological chemistry 29 27756846
2020 FBXO2 Promotes Proliferation of Endometrial Cancer by Ubiquitin-Mediated Degradation of FBN1 in the Regulation of the Cell Cycle and the Autophagy Pathway. Frontiers in cell and developmental biology 28 32984335
2017 FBXO2, a novel marker for metastasis in human gastric cancer. Biochemical and biophysical research communications 27 29269301
2001 OCP1, an F-box protein, co-localizes with OCP2/SKP1 in the cochlear epithelial gap junction region. Hearing research 27 11470190
2023 Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions. Neuro-oncology 26 35802605
2021 FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan. EMBO reports 25 34515398
2004 The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection. Proceedings of the National Academy of Sciences of the United States of America 22 15010529
2003 Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway. Proceedings of the National Academy of Sciences of the United States of America 22 12904574
2019 Comparative ultrafast spectroscopy and structural analysis of OCP1 and OCP2 from Tolypothrix. Biochimica et biophysica acta. Bioenergetics 21 31734194
2020 FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells. Cancer cell international 19 32549792
2025 FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1-Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 15 40791152
2018 Fbxo2VHC mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination. Developmental biology 15 30179592
2003 Toward an understanding of cochlear homeostasis: the impact of location and the role of OCP1 and OCP2. Acta oto-laryngologica 15 12701741
2017 Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease. Neuroscience bulletin 12 28341977
2022 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: Impact of his-tagging and carotenoid type. Biochimica et biophysica acta. Bioenergetics 9 35752265
2024 FBXO2 promotes the progression of papillary thyroid carcinoma through the p53 pathway. Scientific reports 8 39343799
2024 Integrated analysis of scRNA-seq and bulk RNA-seq identifies FBXO2 as a candidate biomarker associated with chemoresistance in HGSOC. Heliyon 7 38590858
2010 FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest. Cell cycle (Georgetown, Tex.) 7 21135578
2024 FBXO2 as a switch guides a special fate of tumor clones evolving into a highly malignant transcriptional subtype in oral squamous cell carcinoma. Apoptosis : an international journal on programmed cell death 6 39487312
2023 Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway. International journal of molecular sciences 6 36982617
2023 Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation. Biochemical genetics 5 38070024
2015 FBG1 Is the Final Arbitrator of A1AT-Z Degradation. PloS one 5 26295339
2009 Conformational stabilities of guinea pig OCP1 and OCP2. Biophysical chemistry 4 19671485
2025 FBXO2 promotes hepatocellular carcinoma progression and sorafenib resistance by targeting USP49 for proteasomal degradation. Frontiers in immunology 2 41035649
2025 FUT2 enhances anti-tumor immunity in pancreatic cancer radiotherapy by driving FBXO2-mediated degradation of NR2F2. Cell death & disease 2 41436429
2025 Fbxo2 inhibits cell proliferation, migration and invasion by the ubiquitin-mediated degradation of WEE1 in renal cell carcinoma. Cellular oncology (Dordrecht, Netherlands) 1 40676478
2025 Cadmium disrupts IL6ST/STAT3 signaling involving FBXO2 in decidualization: Environmental trigger of spontaneous abortion. Ecotoxicology and environmental safety 1 41076860
2025 FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth. The Journal of clinical investigation 1 41401028
2026 p53 and fatty acids collaborate to trigger ferroptosis via the FBXO2-FABP5 axis in colorectal cancer. Redox biology 0 41604941
2025 Research advancements regarding the relationship between FBXO2 and malignant tumors (Review). Molecular medicine reports 0 40999994
2025 Fbxo2 suppresses prostate cancer progression by regulating YTHDF2 ubiquitination and degradation. Cell death & disease 0 41461633

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