Affinage

FBF1

Fas-binding factor 1 · UniProt Q8TES7

Round 2 corrected
Length
1133 aa
Mass
125.4 kDa
Annotated
2026-04-28
129 papers in source corpus 8 papers cited in narrative 8 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FBF1 (Fas-binding factor 1, also called Albatross) is a conserved centriolar protein that localizes to transition fibres/distal appendages and is essential for ciliogenesis by facilitating the ciliary import of assembled intraflagellar transport (IFT) particles through direct interaction with the IFT-B component IFT54 (PMID:23348840, PMID:24231678). FBF1 is recruited to transition fibres by a TALPID3–ANKRD26 complex in a conserved mechanism validated in both C. elegans and mammalian cells (PMID:32366837), and it additionally localizes to proximal centriole ends where it promotes centriole duplication by recruiting HsSAS-6 and facilitates centrosome separation during mitosis through Plk1 recruitment to phosphorylated S348 (PMID:30318703). The Drosophila orthologue (Twitchy) is required for both sensory cilia function and sperm flagellar motility, underscoring a broad role in cilium-dependent processes across species (PMID:34357392). FBF1 overexpression in breast cancer cells activates PI3K/AKT/SOX2 signaling and promotes cancer stemness properties (PMID:39988656).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2000 Low

    Initial molecular cloning identified FBF1 as a large cytoplasmic protein that binds the CD95 (Fas) receptor cytosolic domain, suggesting a potential role in death-receptor signaling — a connection that was not subsequently confirmed by functional studies.

    Evidence Yeast two-hybrid screen against murine CD95 cytoplasmic domain, tissue expression analysis

    PMID:10978533

    Open questions at the time
    • Single yeast two-hybrid interaction with no reciprocal validation or functional follow-up
    • No connection to Fas signaling was replicated in later work
    • Structural basis of the putative interaction undefined
  2. 2013 High

    Quantitative centrosome proteomics and superresolution microscopy repositioned FBF1 as a bona fide distal appendage protein required for ciliogenesis, establishing it as a core component of the DAP complex (CEP83, SCLT1, CEP89, CEP164, FBF1) with its recruitment downstream of SCLT1.

    Evidence Quantitative centrosome proteomics, SIM superresolution microscopy, siRNA knockdown ciliogenesis assays in human cells

    PMID:23348840

    Open questions at the time
    • Molecular mechanism by which FBF1 enables ciliogenesis was not resolved
    • Precise stoichiometry and architecture of DAP ring undefined
  3. 2013 High

    Parallel work in C. elegans and mammalian cells revealed that FBF1 is not a structural transition-fibre component but actively facilitates ciliary import of assembled IFT particles by directly binding the IFT-B subunit IFT54/DYF-11, defining its specific molecular function at the ciliary gate.

    Evidence Forward genetic screen in C. elegans, co-immunoprecipitation of FBF1–IFT54, fluorescence imaging in both organisms

    PMID:24231678

    Open questions at the time
    • Whether FBF1 binds additional IFT components was not tested
    • Structural determinants of the FBF1–IFT54 interaction are unknown
  4. 2018 High

    FBF1 was shown to operate at both centriole poles: at the proximal end it recruits HsSAS-6 for centriole duplication, and it promotes centrosome separation by recruiting Plk1 via phospho-S348, demonstrating that FBF1 integrates ciliogenesis, duplication, and mitotic centrosome functions.

    Evidence Monospecific antibodies, full-length construct rescue, immunofluorescence, functional assays in human cells

    PMID:30318703

    Open questions at the time
    • Kinase responsible for S348 phosphorylation was not identified
    • Whether centriole duplication and ciliogenesis functions are mutually exclusive in a given cell cycle is unclear
  5. 2020 High

    The upstream recruitment mechanism was resolved: a TALPID3–ANKRD26 module is required for FBF1 localization to transition fibres, placing FBF1 downstream in a conserved ciliary-gate assembly pathway.

    Evidence Forward genetic screen in C. elegans, co-immunoprecipitation, co-depletion experiments in mammalian cells

    PMID:32366837

    Open questions at the time
    • Direct versus indirect nature of the TALPID3/ANKRD26–FBF1 interaction is unresolved
    • Whether this recruitment pathway also controls FBF1 at the proximal centriole is untested
  6. 2021 Medium

    FBF1's role was extended to meiotic spindle assembly: depletion in mouse oocytes caused spindle defects, chromosome misalignment, and failure of polar body extrusion, linked to reduced Plk1 expression and localization, paralleling the mitotic Plk1-recruitment function.

    Evidence siRNA microinjection in mouse oocytes, immunofluorescence, Western blot, taxol/nocodazole treatments

    PMID:33561696

    Open questions at the time
    • Single-lab study; independent replication needed
    • Whether the meiotic phenotype acts through phospho-S348/Plk1 binding as in mitosis is untested
  7. 2021 Medium

    The Drosophila orthologue Twitchy demonstrated that FBF1 function extends to cytoplasmic cilia (sperm flagella), where it is dispensable for axoneme assembly but essential for sperm motility, broadening FBF1's role beyond compartmentalized sensory cilia.

    Evidence Loss-of-function genetics, germline-specific RNAi, sperm flagella motility and morphology analysis in Drosophila

    PMID:34357392

    Open questions at the time
    • Molecular target of Twitchy in sperm flagella not identified
    • Whether mammalian FBF1 has an analogous male fertility role is unknown
  8. 2025 Medium

    An oncogenic gain-of-function was described: FBF1 overexpression in breast cancer cells activates PI3K/AKT signaling by directly binding PI3K, leading to SOX2-dependent stemness — a function seemingly independent of its centriolar roles.

    Evidence Co-immunoprecipitation, RNA-seq, xenograft models, PI3K inhibitor rescue in breast cancer cells

    PMID:39988656

    Open questions at the time
    • PI3K binding domain on FBF1 not mapped
    • Whether this PI3K interaction occurs in non-cancer contexts is unknown
    • Relationship to FBF1's centriolar functions is unexplored

Open questions

Synthesis pass · forward-looking unresolved questions
  • No structural model of FBF1 exists, the kinase phosphorylating S348 is unidentified, and whether FBF1's centriolar and PI3K-signaling functions are mechanistically linked or context-dependent remains unresolved.
  • No crystal or cryo-EM structure available
  • S348 kinase identity unknown
  • No disease-causative mutations reported in humans

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005929 cilium 3 GO:0005815 microtubule organizing center 2 GO:0005856 cytoskeleton 1
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-1640170 Cell Cycle 2
Partners
ANKRD26CEP164CEP83IFT54PLK1SASS6SCLT1TALPID3
Complex memberships
Distal appendage complex (CEP83–SCLT1–CEP89–CEP164–FBF1)TALPID3–ANKRD26–FBF1 transition fibre module

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 FBF1 is a distal appendage protein (DAP) of centrioles required for ciliogenesis. Together with CEP83, SCLT1, CEP89, and CEP164, FBF1 constitutes the DAP complex. Using quantitative centrosome proteomics and superresolution microscopy, FBF1 was identified as a novel DAP component. Depletion of FBF1 blocks ciliogenesis, and DAP assembly hierarchy places FBF1 recruitment downstream of SCLT1 but independent of CEP89. Quantitative centrosome proteomics, superresolution microscopy, siRNA knockdown, ciliogenesis assays Genes & development High 23348840
2013 FBF1 (transition fibre protein) is required for the ciliary import of assembled intraflagellar transport (IFT) particles at the ciliary base. FBF1 localizes specifically to transition fibres and directly interacts with the IFT-B component IFT54 (DYF-11 in C. elegans). Although FBF1 is not a structural component of transition fibres, it actively facilitates transit of assembled IFT particles through the ciliary base. This function is conserved between human FBF1 and its C. elegans homologue DYF-19. Whole-genome screen for ciliogenesis mutants, co-immunoprecipitation, fluorescence imaging, localization studies in C. elegans and mammalian cells Nature communications High 24231678
2018 Albatross/FBF1 localizes to both distal and proximal ends of centrioles and has roles beyond ciliogenesis. FBF1 mediates centriole duplication by recruiting the cartwheel protein HsSAS-6. Additionally, FBF1 participates in centrosome separation during mitosis by recruiting Plk1 to phosphorylated serine 348 (S348) of FBF1. Thus FBF1 spatiotemporally integrates ciliogenesis, centriole duplication, and centrosome separation. Monospecific antibodies, full-length construct expression, siRNA rescue experiments, immunofluorescence, functional assays for centriole duplication and centrosome separation Genes to cells : devoted to molecular & cellular mechanisms High 30318703
2020 TALPID3 and ANKRD26 form a complex with FBF1 at transition fibres (TFs) to orchestrate proper cilia gating. Co-depletion of TALPID3 and ANKRD26 specifically impairs the recruitment of FBF1 to TFs in both C. elegans (TALP-3/ANKR-26/DYF-19) and mammalian cells, establishing a conserved protein module that regulates the functional component of the ciliary gate. Forward genetic screen in C. elegans, genetic analysis, co-immunoprecipitation, mammalian cell depletion experiments, fluorescence imaging of TF localization Nature communications High 32366837
2021 Fbf1 localizes to spindle poles and around microtubules in mouse oocytes. siRNA-mediated depletion of Fbf1 causes severe spindle abnormalities, chromosome misalignment, decreased microtubule aggregation, disruption of first meiosis, and failure of first polar body extrusion. Fbf1 depletion also reduces Plk1 expression and its localization to spindle poles, and activates the spindle assembly checkpoint component BubR1, indicating Fbf1 controls microtubule dynamics and spindle assembly during meiosis through Plk1. Immunofluorescence, siRNA microinjection, Western blot, taxol/nocodazole treatment, spindle assembly checkpoint analysis Theriogenology Medium 33561696
2021 Twitchy, the Drosophila orthologue of FBF1/DYF-19, is required for coordinated locomotion and male fertility. Loss-of-function mutants display uncoordinated phenotype consistent with sensory cilia defects. Germline-specific RNAi knockdown produces fertile-bodied but infertile males; their sperm flagellar axonemes form and elongate and undergo polyglycylation but fail to produce motile sperm, indicating twitchy/FBF1 functions in both compartmentalised sensory cilia and cytoplasmic sperm flagella. Loss-of-function genetics, RNAi germline-specific knockdown, sperm flagella morphology and motility analysis, polyglycylation immunostaining Biology open Medium 34357392
2000 A novel protein termed Fbf-1 (Fas binding factor 1) was identified as a binding partner of the cytosolic domain of the murine CD95 (Fas/Apo-1) receptor via yeast two-hybrid assay. Fbf-1 is 1173 amino acids (~130 kDa), expressed broadly across tissues, localizes to the cytoplasm, contains a C-terminal leucine heptad repeat, and shows sequence similarity to trichohyalin and plectin, suggesting a structural protein role. It bears no similarity to known CD95 adaptor proteins. Yeast two-hybrid assay, sequence analysis, tissue expression analysis, subcellular localization Biochimica et biophysica acta Low 10978533
2025 FBF1 promotes breast cancer stem cell (CSC) properties via a PI3K/AKT/SOX2 axis. FBF1 overexpression increases side population, sphere formation, and expression of core stemness genes (SOX2, OCT4, KLF4, NANOG), while FBF1 silencing reduces CSC properties. Mechanistically, FBF1 binds PI3K, activating PI3K-AKT phosphorylation; activated p-AKT then interacts with SOX2 to elevate SOX2 and OCT4 activity. PI3K inhibitors abolish FBF1-mediated signaling and stemness in vitro and in vivo. siRNA silencing, FBF1 overexpression, RNA sequencing, co-immunoprecipitation, immunofluorescence, xenograft model, PI3K inhibitor treatment, tissue microarray IHC Stem cell research & therapy Medium 39988656

Source papers

Stage 0 corpus · 129 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 An empirical framework for binary interactome mapping. Nature methods 652 19060904
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science signaling 383 24255178
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2013 Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes & development 336 23348840
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2011 Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. The EMBO journal 265 21399614
2011 Next-generation sequencing to generate interactome datasets. Nature methods 200 21516116
2011 Protein interactome reveals converging molecular pathways among autism disorders. Science translational medicine 180 21653829
2004 FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Developmental cell 149 15525531
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
2011 Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. The Journal of biological chemistry 131 21832049
2009 HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS pathogens 126 19242562
2001 Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA research : an international journal for rapid publication of reports on genes and genomes 123 11347906
2005 Binding specificity and mRNA targets of a C. elegans PUF protein, FBF-1. RNA (New York, N.Y.) 116 15769874
2021 Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 113 34349018
1999 Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin. Journal of bacteriology 113 10572140
2014 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nature communications 111 24722188
2019 Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Genes & development 110 31753913
2018 Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Molecular & cellular proteomics : MCP 101 30021884
2013 Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes. Nature communications 98 24231678
2021 SARS-CoV-2-host proteome interactions for antiviral drug discovery. Molecular systems biology 86 34709727
2020 Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets 84 31959025
2006 Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology (Baltimore, Md.) 84 16729319
1992 The gene for dominant white color in the pig is closely linked to ALB and PDGRFRA on chromosome 8. Genomics 80 1362182
2000 Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity. Journal of bacteriology 78 10809709
2016 Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Cell reports 77 26972000
2011 Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice. PloS one 73 22162746
2006 Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response. PLoS pathogens 65 16789836
2013 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nature communications 64 23443559
2018 An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Nature genetics 61 29892012
2005 Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 61 16037210
2019 Multi-Step Topochemical Pathway to Metastable Mo2AlB2 and Related Two-Dimensional Nanosheet Heterostructures. Journal of the American Chemical Society 56 31199138
2004 Subtilosin production by two Bacillus subtilis subspecies and variance of the sbo-alb cluster. Applied and environmental microbiology 56 15066831
2020 In vivo evaluation of the biocompatibility and biodegradation of a new denatured plasma membrane combined with liquid PRF (Alb-PRF). Platelets 55 32531175
1982 Immunocytochemical localisation of alpha-fetoprotein (AFP) and serum albumin (ALB) in ecto-, meso- and endodermal tissue derivatives of the developing rat. Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine 52 6181479
2010 The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. Development (Cambridge, England) 50 20431119
2019 TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Proceedings of the National Academy of Sciences of the United States of America 48 31182584
2000 Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis. Journal of bacteriology 41 10809710
2003 Establishment of Alb-DsRed2 transgenic rat for liver regeneration research. Biochemical and biophysical research communications 31 14592439
2021 Rational Design, Pharmacomodulation, and Synthesis of [68Ga]Ga-Alb-FAPtp-01, a Selective Tumor-Associated Fibroblast Activation Protein Tracer for PET Imaging of Glioma. ACS sensors 30 34415143
2009 Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)). American journal of physiology. Renal physiology 29 19403647
2019 A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro. Journal of enzyme inhibition and medicinal chemistry 26 30734599
1993 In situ hybridization mapping and restriction fragment length polymorphism analysis of the porcine albumin (ALB) and transferrin (TF) genes. Animal genetics 26 8101068
2020 TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nature communications 23 32366837
2007 Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers. Occupational and environmental medicine 20 17449561
2006 Molecular characterization of the genetic lesion in Dystonia musculorum (dt-Alb) mice. Brain research 20 16725123
2015 Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities. Stem cell research & therapy 19 25889844
2020 Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2. eLife 17 32804074
2022 RDW-to-ALB Ratio Is an Independent Predictor for 30-Day All-Cause Mortality in Patients with Acute Ischemic Stroke: A Retrospective Analysis from the MIMIC-IV Database. Behavioural neurology 16 36567762
2021 Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis. Biochimica et biophysica acta. Molecular basis of disease 16 33513427
2020 HGF and IL-10 expressing ALB::GFP reporter cells generated from iPSCs show robust anti-fibrotic property in acute fibrotic liver model. Stem cell research & therapy 15 32746905
2020 MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy. Cardiovascular therapeutics 13 32695227
2000 A novel protein (Fbf-1) that binds to CD95/APO-1/FAS and shows sequence similarity to trichohyalin and plectin. Biochimica et biophysica acta 13 10978533
2017 A New Long Noncoding RNA ALB Regulates Autophagy by Enhancing the Transformation of LC3BI to LC3BII during Human Lens Development. Molecular therapy. Nucleic acids 12 29246299
2022 The clinical value of high mobility group box-1 and CRP/Alb ratio in the diagnosis and evaluation of sepsis in children. European review for medical and pharmacological sciences 11 36111938
2017 First Report of Familial Dysalbuminemic Hyperthyroxinemia With an ALB Variant. Annals of laboratory medicine 10 27834068
2012 Genetic variations of CYP2B6 gene were associated with plasma BPDE-Alb adducts and DNA damage levels in coke oven workers. Toxicology letters 10 22521834
2007 Characterization of Aplysia Alb-1, a candidate water-borne protein pheromone released during egg laying. Peptides 10 18190999
2023 Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial. Journal of functional biomaterials 9 37888172
2021 LDH, CRP and ALB predict nucleic acid turn negative within 14 days in symptomatic patients with COVID-19. Scottish medical journal 9 33663273
1996 The translational inhibitor cycloheximide represses growth factor depletion-induced apoptosis in an alb-SV40T transgenic rat liver cell line. Hepatology (Baltimore, Md.) 9 8675182
2024 Cordycepin enhances anti-tumor immunity in breast cancer by enhanceing ALB expression. Heliyon 8 38720766
2024 Effect of Rhei Radix Et Rhizome on treatment of polycystic ovary syndrome by regulating PI3K/AKT pathway and targeting EGFR/ALB in rats. Journal of ethnopharmacology 8 39491761
2014 Ethanol affects hepatitis C pathogenesis: humanized SCID Alb-uPA mouse model. Biochemical and biophysical research communications 8 24953695
2010 Kidneys of Alb/TGF-beta1 transgenic mice are deficient in retinoic acid and exogenous retinoic acid shows dose-dependent toxicity. Nephron. Experimental nephrology 8 20110732
1998 Sequence and functional characterization of RNase P RNA from the chl alb containing cyanobacterium Prochlorothrix hollandica. FEBS letters 8 9654127
2025 ALB inhibits tumor cell proliferation and invasion by regulating immune microenvironment and endoplasmic reticulum stress in clear cell renal cell carcinoma. Biochimica et biophysica acta. Molecular basis of disease 7 39862995
2024 ALB-PRF facilitates chondrogenesis by promoting chondrocytes migration, proliferation and differentiation. Platelets 7 39431681
2022 Albatrellus confluens (Alb. & Schwein.) Kotl. & Pouz.: Natural Fungal Compounds and Synthetic Derivatives with In Vitro Anthelmintic Activities and Antiproliferative Effects against Two Human Cancer Cell Lines. Molecules (Basel, Switzerland) 7 35566312
2022 Albumin (ALB) and protein disulfide isomerase family A member 4 (PDIA4) are novel markers to predict sperm freezability of Erhualian boar. Cryobiology 7 36181861
2019 The Associations of PMF1, ICAM1, AGT, TRIM65, FBF1, and ACOX1 Variants With Leukoaraiosis in Chinese Population. Frontiers in genetics 7 31396257
2013 Construction of a single lentiviral vector containing tetracycline-inducible Alb-uPA for transduction of uPA expression in murine hepatocytes. PloS one 7 23626683
2010 [Clinical characteristics and ALB gene mutation analysis of Korean patients with bisalbuminemia]. The Korean journal of laboratory medicine 7 20603593
2023 WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner. Environmental toxicology 6 36988233
2021 Fbf1 regulates mouse oocyte meiosis by influencing Plk1. Theriogenology 6 33561696
2018 Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Genes to cells : devoted to molecular & cellular mechanisms 6 30318703
1994 Linkage of bovine erythrocyte antigen loci B, C, L, S, Z, R' and T' and the serum protein loci post-transferrin 2 (PTF 2), vitamin D binding protein (GC) and albumin (ALB) to DNA microsatellite markers. Animal genetics 6 7943946
1992 Demonstration of serum albumin (ALB) polymorphism in wild rabbits, Oryctolagus cuniculus, by means of isoelectric focusing. Animal genetics 6 1503263
1987 Distributions of two recently inserted long interspersed elements of the L1 repetitive family at the Alb and beta h3 loci in wild mice populations. Molecular biology and evolution 6 2833674
2024 Effects of individualized comprehensive nutritional support on inflammatory markers, serum amylase (AMS), prealbumin (PA), albumin (ALB), calcium ion (Ca2+) in patients with severe pancreatitis. Journal of medical biochemistry 5 39980616
2006 Separate origins of hepatitis B virus surface antigen-negative foci and hepatocellular carcinomas in transgenic HBsAg (alb/psx) mice. The American journal of pathology 5 16816375
2022 Identification of SNPs and expression patterns of ALB, AHSG and GC genes and their association with growth traits in Hu sheep. Gene 4 36470483
2021 Rapid molecular diagnosis of ALB gene variants prevents unnecessary interventions in familial dysalbuminemic hyperthyroxinemia. Journal of pediatric endocrinology & metabolism : JPEM 4 34142517
2025 FBF1 maintains stem cell-like properties in breast cancer via PI3K/AKT/SOX2 axis. Stem cell research & therapy 3 39988656
2025 Correlation Between Serum D-Dimer, NLR, and CRP/ALB in Patients with Acute Ischemic Stroke. International journal of general medicine 3 40453200
2025 Relationship Between CRP/ALB Ratio and Severity of Coronary Artery Lesions in Hypertensive Patients with Acute Myocardial Infarction. Medical science monitor : international medical journal of experimental and clinical research 3 40616257
2024 SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 3 38876053
2024 The Radio of RDW/ALB: A Cost-Effective Biomarker for Early-Stage Risk Stratification in Acute Ischemic Stroke. International journal of general medicine 3 39355341
2022 ALB, HP, OAF and RBP4 as novel protein biomarkers for identifying cured patients with pulmonary tuberculosis by DIA. Clinica chimica acta; international journal of clinical chemistry 3 35964702
2021 Twitchy, the Drosophila orthologue of the ciliary gating protein FBF1/dyf-19, is required for coordinated locomotion and male fertility. Biology open 3 34357392
2021 Adsorption behavior of mercaptopurine and 6-thioguanine drugs on the B12N12, AlB11N12 and GaB11N12 nanoclusters, a comparative DFT study. Journal of biomolecular structure & dynamics 3 34380372
2020 Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4. Human cell 3 32474770
2009 Characterization of hepatic sexual dimorphism in Alb-DsRed2 transgenic rats. Biochemical and biophysical research communications 3 19250923
2004 The effect of HSV-tk/GCV on hepatic specific damage driven by murine ALB promoter/enhancer. Yi chuan xue bao = Acta genetica Sinica 3 15552038
2025 Impact of 'Internet + dietary diary management' on serum TP, ALB, PA levels and nutritional risk for elderly patients with esophageal cancer. Experimental gerontology 2 40334756
2024 Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality. Aging 2 38656880
2023 WTAP contributes to the tumorigenesis of osteosarcoma via modulating ALB in an m6A-dependent manner. Genomics 2 36690262
2022 An ab initio investigation of the temperature-dependent energetic barriers towards CrAlB and (Mo,Cr)AlB formation in a metastable synthesis scenario. Nanoscale 2 36040215
2021 rs1445776009 variants in the human ALB gene: Association with serum albumin and clinical outcomes in HIV-infected Kenyan injection substance users. International journal of health sciences 2 34234630
2019 Congenital Analbuminemia in a Korean Male Diagnosed with Single Nucleotide Polymorphism in the ALB Gene: The First Case Reported in Korea. Yonsei medical journal 2 31250585
2018 Diagnostic value of urinary RBP, ALB and AQP2 in neonatal hydronephrosis and the relationship with expression of MCP-1 in the prenatal maternal peripheral blood. Experimental and therapeutic medicine 2 30651806
1991 PCR-based detection of a polymorphic HaeIII site in intron VII of the human albumin (ALB) gene. Nucleic acids research 2 1684852
2025 Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation. Biomolecules & biomedicine 1 39569650
2024 COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells. Genetics 1 38427913
2023 Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130. Journal of bioenergetics and biomembranes 1 37940722
2010 Transplant of Primary Human Hepatocytes Cocultured With Bone Marrow Stromal Cells to SCID Alb-uPA Mice. Cell medicine 1 26966632
1992 Preparation of an RGD ALB conjugate. In vitro analysis of cellular responses. ASAIO journal (American Society for Artificial Internal Organs : 1992) 1 1457864
2026 ALB, GPX5 and PTGDS as potential biomarkers for the aging processes of the dog epididymis. Reproduction, fertility, and development 0 41433920
2026 ALB suppresses epithelial-mesenchymal transition and glycolysis via SPARC regulation in metastatic clear cell renal cell carcinoma. Biochemical and biophysical research communications 0 41610717
2026 Intramolecular Interactions of Twenty-Eight Amide Derivatives with the C-ALB Kinase using a Theoretical Model as a Therapeutic Alternative to Treat Cancer. Drug research 0 41633373
2026 Microneedling (MN) combined with albumin gel and liquid platelet-rich fibrin mixtures (Alb-PRF) promotes periodontal soft tissue regeneration in SD rats. Biomedical materials (Bristol, England) 0 41861411
2025 Caenorhabditis elegans FBF-1 and FBF-2 C-terminal intrinsically disordered regions differentially regulate RNA-binding affinity. RNA (New York, N.Y.) 0 40769718
2025 Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support. Journal of medical biochemistry 0 40837358
2025 Whole transcriptome analysis identifies ALB-EEF1A1 fusion as a novel biomarker in metastatic colorectal cancer. Cancer pathogenesis and therapy 0 40923023
2024 Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children. Journal of pediatric endocrinology & metabolism : JPEM 0 38736368
2024 Exercise Alters FBF1-Regulated Novel-miRNA-1135 Associated with Hydrolethalus Syndrome 1 in Rheumatoid Arthritis: A Preliminary Study. MicroRNA (Shariqah, United Arab Emirates) 0 38963098
2023 Feasibility analysis of TCB, hs-CRP, and UCB/ALB as outcome measures for dynamic assessment during phototherapy of neonates with Hyperbilirubinemia. Biotechnology & genetic engineering reviews 0 37035928
2019 RBP and Alb in neonatal hydronephrosis and its association with IL-12 levels in pregnant women before delivery. Experimental and therapeutic medicine 0 31258686
1992 [Effects of oxygen free radicals on cell growth and productions of alpha-fetoprotein (AFP) and albumin (ALB) by human hepatoma cell line (HH2-6)]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 0 1380996