Affinage

FAM13A

Protein FAM13A · UniProt O94988

Length
1023 aa
Mass
116.9 kDa
Annotated
2026-06-09
50 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FAM13A is a RhoGAP-domain protein that functions as a negative regulator of Wnt/β-catenin signaling and Rho-dependent cytoskeletal dynamics, coordinating epithelial repair, fibrosis, and metabolic homeostasis (PMID:26862784, PMID:38691660). It recruits PP2A together with GSK3β and β-catenin to drive β-catenin degradation, and loss of this activity sensitizes lung epithelium to Wnt-mediated emphysematous injury and augments alveolar progenitor proliferation (PMID:26862784, PMID:34224973). FAM13A subcellular partitioning is set by reversible phosphorylation at Ser-322: AKT-mediated phosphorylation enhances 14-3-3 binding and cytoplasmic sequestration, whereas B56-containing PP2A dephosphorylates this site to promote nuclear localization (PMID:25609086). AKT phosphorylation at Ser-312 following cigarette smoke exposure creates a degron recognized by the CUL4A/DDB1/DCAF1 E3 ubiquitin ligase, triggering FAM13A ubiquitination and degradation that accelerates epithelial proliferation during injury recovery (PMID:36749583). The long isoform carries a biochemically validated N-terminal RhoGAP domain, and FAM13A restrains RhoA activity and F-actin stress fiber formation in airway epithelium while supporting cilia-coordinated mucociliary transport (PMID:29239766, PMID:38691660). FAM13A additionally negatively regulates TGFβ2 secretion via an AP-3/AP3D1 transport pathway (PMID:34166600), represses AMPK activity to govern hepatic lipid and glucose metabolism (PMID:32151973), and restrains adipocyte differentiation and lipolysis (PMID:32193374, PMID:29487953).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2015 High

    Established how FAM13A nuclear-cytoplasmic distribution is controlled, defining a phospho-switch that gates its access to Wnt signaling machinery.

    Evidence In vitro phosphorylation with Ser-322 mutagenesis, 14-3-3 Co-IP, subcellular fractionation, and KO mice plus Wnt reporter in lung cancer cells

    PMID:25609086

    Open questions at the time
    • Did not resolve which nuclear targets FAM13A engages once localized
    • Functional consequence of nuclear vs cytoplasmic pools on β-catenin not fully dissected
  2. 2016 High

    Defined the core biochemical mechanism by which FAM13A suppresses Wnt signaling — scaffolding a PP2A–GSK3β–β-catenin complex to drive β-catenin degradation — and tied it to emphysema resistance in vivo.

    Evidence IP-MS, Fam13a knockout mice, and pharmacological β-catenin inhibitor epistasis across two emphysema injury models

    PMID:26862784

    Open questions at the time
    • Structural basis of the multiprotein scaffold not determined
    • Whether RhoGAP activity contributes to this complex unaddressed
  3. 2017 Medium

    Showed FAM13A restrains RhoA activity and actin cytoskeleton remodeling in lung epithelium, linking its loss to stress fiber formation and EMT marker changes.

    Evidence siRNA knockdown with RhoA activity assay and F-actin imaging in A549 and primary CF bronchial cells

    PMID:29239766

    Open questions at the time
    • Direct GAP activity not biochemically demonstrated in this study
    • EMT marker changes correlative, not mechanistically linked to RhoA
  4. 2018 Low

    Extended the β-catenin-suppressive role of FAM13A to adipogenesis and lipolysis, positioning it upstream of PPARγ.

    Evidence Overexpression in 3T3-L1 with pioglitazone rescue; knockdown lipolysis assays in human MSCs

    PMID:29487953 PMID:30301961

    Open questions at the time
    • 3T3-L1 overexpression lacks endogenous/knockin validation
    • Direct β-catenin–PPARγ mechanistic link not established
  5. 2020 Medium

    Established FAM13A's roles in systemic metabolism, repressing AMPK and mitochondrial respiration in hepatocytes and restraining adipocyte differentiation and fat distribution.

    Evidence Fam13a KO mice on high-fat diet with AMPK and mitochondrial respiration assays in hepatocytes; adipose phenotyping and preadipocyte knockdown

    PMID:32151973 PMID:32193374

    Open questions at the time
    • Molecular link between FAM13A and AMPK not defined
    • Mechanism connecting Wnt/β-catenin regulation to metabolic phenotypes unclear
  6. 2021 Medium

    Diversified FAM13A's mechanistic repertoire — identifying it as a negative regulator of AP-3-dependent TGFβ2 secretion, a restrainer of Wnt-mediated alveolar progenitor regeneration, and a protector against TGFβ1-driven fibrotic responses.

    Evidence Co-IP of FAM13A–TGFβ2–AP3D1 with secretion assays; KO Wnt-reporter mice with alveolar organoids; CRISPR KO/overexpression in airway epithelium with barrier and fibrotic readouts

    PMID:33919074 PMID:34105356 PMID:34166600 PMID:34224973

    Open questions at the time
    • Whether TGFβ2 transport, Wnt suppression, and RhoGAP functions are mechanistically coupled is unknown
    • Domain requirements for AP-3 pathway regulation not mapped
  7. 2023 High

    Identified the degradation arm of FAM13A regulation, showing AKT phosphorylation at Ser-312 generates a CUL4A/DCAF1 degron that lowers FAM13A levels to accelerate epithelial proliferation during repair.

    Evidence In vitro kinase assay, Ser-312 mutagenesis, Co-IP with DCAF1/CUL4A, ubiquitination assay, and two mouse injury models

    PMID:36749583

    Open questions at the time
    • Relationship between Ser-312 degron and Ser-322 localization switch not integrated
    • Whether degradation selectively affects specific FAM13A functions unknown
  8. 2024 High

    Provided direct biochemical proof of FAM13A RhoGAP activity in its long isoform and assigned an isoform-specific role in cilia-coordinated mucociliary transport.

    Evidence In vitro RhoGAP assay with purified protein, Xenopus morpholino knockdown, and mucociliary transport assays in human airway cells

    PMID:38691660

    Open questions at the time
    • Rho substrate specificity beyond RhoA not fully delineated
    • How RhoGAP activity coordinates with the β-catenin scaffold function unresolved
  9. 2026 Medium

    Demonstrated the long isoform is required for lung epithelial lineage emergence from human iPSCs through Wnt/β-catenin regulation during early progenitor patterning.

    Evidence Isoform-specific CRISPR disruption in human iPSC-directed lung differentiation with lineage and pathway readouts

    PMID:42083809

    Open questions at the time
    • Whether RhoGAP activity or β-catenin scaffolding drives the lineage phenotype not separated
    • Stage-specific Wnt regulation mechanism not detailed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FAM13A's distinct molecular activities — RhoGAP catalysis, PP2A/β-catenin scaffolding, AP-3 transport regulation, and AMPK repression — are partitioned across isoforms, subcellular pools, and tissues to produce its diverse phenotypes remains unresolved.
  • No structural model integrating the RhoGAP domain with the β-catenin-degrading scaffold
  • Mechanism linking FAM13A to AMPK repression undefined
  • Validated direct binding partners from candidate screens still lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 2 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1430728 Metabolism 2
Partners
AP3D1CTNNB1CUL4ADCAF1GSK3BPP2ATGFB2YWHA+ (14-3-3)

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 FAM13A interacts with protein phosphatase 2A (PP2A) and recruits PP2A together with glycogen synthase kinase 3β (GSK3β) and β-catenin, inducing β-catenin degradation. Fam13a-knockout mice were resistant to cigarette smoke-induced and elastase-induced emphysema, and this resistance was reversed by co-administration of a β-catenin inhibitor, placing FAM13A upstream of β-catenin stability. Co-immunoprecipitation followed by mass spectrometry (IP-MS); Fam13a knockout mouse model; pharmacological rescue with β-catenin inhibitor American journal of respiratory and critical care medicine High 26862784
2015 B56-containing PP2A and Akt act antagonistically to control reversible phosphorylation of Fam13a on Ser-322. When phosphorylated by Akt at Ser-322, Fam13a binds 14-3-3 with enhanced affinity, leading to cytoplasmic sequestration. B56-containing PP2As dephosphorylate phospho-Ser-322 and promote nuclear localization of Fam13a. Additionally, Fam13a has the ability to activate the Wnt pathway in human lung cancer cells. In vitro phosphorylation assay; site-directed mutagenesis (Ser-322); subcellular fractionation; co-immunoprecipitation with 14-3-3; Fam13a-knockout mouse generation; Wnt reporter assays in lung cancer cells Molecular biology of the cell High 25609086
2021 FAM13A forms a cellular protein complex with TGFβ2 and AP3D1 (adaptor protein 3 subunit). This complex mediates TGFβ2 secretion through an AP-3-dependent intracellular transport pathway, with FAM13A acting as a negative regulator targeting a late stage of transport involving dissociation of coat-cargo interaction. TGFβ2 is identified as a transmembrane protein delivered to late endosomal compartments for subsequent exosomal secretion via this pathway. Co-immunoprecipitation; protein-protein interaction network analysis; functional transport/secretion assays in cells American journal of respiratory cell and molecular biology Medium 34166600
2017 FAM13A knockdown in lung epithelial cells (A549 and primary bronchial epithelial cells from CF patients) leads to increased RhoA activity, induction of F-actin stress fibers, and changes in epithelial-mesenchymal transition (EMT) markers including E-cadherin, α-smooth muscle actin, and vimentin. IL-1β and TGFβ reduce FAM13A expression. siRNA knockdown; RhoA activity assay; immunofluorescence of F-actin; western blotting for EMT markers; primary CF patient cells Journal of cystic fibrosis Medium 29239766
2023 AKT kinase phosphorylates FAM13A at serine residue 312 following cigarette smoke extract treatment, and this phosphorylation is recognized by the CUL4A/DDB1/DCAF1 E3 ubiquitin ligase complex, leading to ubiquitination-mediated degradation of FAM13A. Reduced FAM13A protein levels resulting from this pathway accelerate epithelial cell proliferation during lung injury recovery. In vitro kinase assay; site-directed mutagenesis; co-immunoprecipitation with DCAF1/CUL4A; ubiquitination assay; in vivo mouse injury models (influenza, naphthalene); cell proliferation assays American journal of respiratory cell and molecular biology High 36749583
2024 The long isoform of FAM13A, predominantly expressed in multiciliated airway epithelial cells, contains a functional N-terminal RhoGAP domain with directly demonstrated RhoGAP activity using purified proteins. In Xenopus laevis, Fam13a deficiency impaired cilia-dependent embryo motility. In human primary epithelial cells, long-isoform deficiency reduced cilia coordination in mucociliary transport assays without affecting multiciliogenesis. In vitro RhoGAP activity assay with purified proteins; Xenopus Fam13a morpholino knockdown; mucociliary transport assays in human primary airway epithelial cells; isoform-specific expression analysis American journal of respiratory cell and molecular biology High 38691660
2020 FAM13A knockdown in preadipocytes accelerates adipocyte differentiation. Fam13a knockout mice show a lower visceral-to-subcutaneous fat (VAT/SAT) ratio after high-fat diet challenge and subcutaneous adipocytes shift toward a greater number of smaller adipocytes with improved adipogenic potential. siRNA knockdown in human preadipocyte models; Fam13a knockout mouse adipose phenotyping under high-fat diet; adipocyte size/number analysis Nature communications Medium 32193374
2020 Loss of Fam13a in mice leads to activation of AMP-activated protein kinase (AMPK) and increased mitochondrial respiration in primary hepatocytes, protecting from high-fat diet-induced fatty liver. FAM13A thus acts as a repressor of AMPK activity in hepatic glucose and lipid metabolism. Fam13a knockout mice on high-fat diet; AMPK activity assay; mitochondrial respiration measurement in primary hepatocytes; reporter assay for regulatory variant rs2276936 iScience Medium 32151973
2021 FAM13A deficiency increases Wnt/β-catenin activation in lung epithelial cells (especially alveolar type II cells) in vivo after cigarette smoke exposure, and enhances the proliferation and differentiation capacity of alveolar epithelial progenitor cells in ex vivo organoid culture, demonstrating a tempo-spatial role of FAM13A in restraining Wnt-mediated alveolar epithelial repair/regeneration. Fam13a-knockout crossed with TCF/Lef:H2B-GFP Wnt reporter mice; flow cytometry; alveolar organoid culture; immunofluorescence; single-cell RNA-seq from COPD lungs EBioMedicine Medium 34224973
2021 FAM13A overexpression in airway epithelial cells accelerates build-up of epithelial resistance and increases E-cadherin expression, while reducing CSE-induced CXCL8 secretion. FAM13A-knockout airway epithelial cells show augmented TGF-β1-induced collagen (COL1A1) and MMP2 expression mediated by increased β-catenin expression, indicating FAM13A protects from TGF-β1-induced fibrotic responses by sequestering β-catenin. CRISPR-Cas9 FAM13A knockout in airway epithelial cells; lipid nanoparticle-mediated FAM13A overexpression; transepithelial electrical resistance measurement; western blotting; ELISA for CXCL8 American journal of physiology. Lung cellular and molecular physiology Medium 34105356
2021 FAM13A silencing in NSCLC cells disrupts F-actin cytoskeleton architecture and suppresses migration and invasion, particularly under hypoxic conditions. FAM13A knockdown also induces S-phase cell cycle arrest and reduces proliferation, without affecting apoptosis. Lentiviral shRNA knockdown; MTS proliferation assay; wound healing assay; invasion assay; BrdU assay; APC Annexin V apoptosis staining; F-actin immunofluorescence International journal of molecular sciences Medium 33919074
2018 FAM13A knockdown in human adipose-derived mesenchymal stem cells increases lipolysis approximately 1.5-fold and upregulates LIPE (hormone-sensitive lipase) expression, identifying FAM13A as a regulator of adipocyte lipolysis. siRNA knockdown in human mesenchymal stem cells; glycerol release lipolysis assay; gene expression by qPCR Diabetologia Medium 29487953
2023 FAM13A overexpression in airway epithelial 16HBE cells reduces paraquat-induced P21 (CDKN1A) expression and mitochondrial ROS production, indicating FAM13A negatively regulates cellular senescence via suppression of P21 and mitochondrial oxidative stress. FAM13A overexpression in 16HBE cells; paraquat-induced senescence model; qPCR for P21; MitoSOX staining for mitochondrial ROS; immunohistochemistry in COPD lung tissue American journal of physiology. Lung cellular and molecular physiology Medium 37605846
2021 miR-30a-5p targets the FAM13A 3'-UTR (confirmed by dual-luciferase reporter assay), reducing FAM13A expression and promoting adipogenic differentiation of bone marrow mesenchymal stem cells. FAM13A reduces adipogenic differentiation by activating the Wnt/β-catenin signaling pathway. Dual-luciferase reporter assay; miR-30a-5p overexpression; western blotting for Wnt/β-catenin pathway proteins; Oil Red O staining; RT-qPCR Molecular medicine reports Low 34821370
2020 Two-hybrid screening in a human lung cancer cDNA library identified several high-confidence protein partners of FAM13A, providing candidate interaction partners for further mechanistic investigation. Specific partners were identified but not individually validated in this study. Yeast two-hybrid screening with human lung cancer cDNA library BMC research notes Low 31900205
2026 The long isoform of FAM13A is required for the emergence of mature airway and alveolar epithelial lineages from human iPSCs during directed differentiation. Specific loss of the long isoform dysregulates Wnt/β-catenin signaling during early patterning of NKX2-1+ lung progenitor cells in vitro. CRISPR-Cas9 isoform-specific disruption in human iPSCs; directed differentiation to lung epithelium; immunostaining; gene expression analysis American journal of respiratory cell and molecular biology Medium 42083809
2018 FAM13A overexpression in 3T3-L1 preadipocytes downregulates β-catenin signaling and renders preadipocytes more susceptible to apoptosis, and largely blocks adipogenesis induced by standard hormone cocktail; adipogenesis can be partially rescued by the PPARγ agonist pioglitazone, placing FAM13A upstream of PPARγ in adipogenesis. FAM13A overexpression in 3T3-L1 cells; western blotting for β-catenin; adipogenesis assay; apoptosis assay; pharmacological rescue with pioglitazone International journal of obesity Low 30301961

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. American journal of respiratory and critical care medicine 105 26862784
2019 microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model. Experimental & molecular medicine 77 31164635
2010 FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. The application of clinical genetics 57 23776362
2020 FAM13A affects body fat distribution and adipocyte function. Nature communications 51 32193374
2015 Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt. Molecular biology of the cell 48 25609086
2004 Cloning and characterization of FAM13A1--a gene near a milk protein QTL on BTA6: evidence for population-wide linkage disequilibrium in Israeli Holsteins. Genomics 46 15234000
2016 Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. The Journal of allergy and clinical immunology 45 27612410
2019 Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays. American journal of respiratory and critical care medicine 44 30079747
2017 FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 41 29239766
2016 FAM13A is associated with non-small cell lung cancer (NSCLC) progression and controls tumor cell proliferation and survival. Oncoimmunology 37 28197372
2014 Moving beyond genetics: is FAM13A a major biological contributor in lung physiology and chronic lung diseases? Journal of medical genetics 34 25163686
2018 FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study. Diabetologia 28 29487953
2013 Association of FAM13A polymorphisms with COPD and COPD-related phenotypes in Han Chinese. Clinical biochemistry 24 23891779
2021 Hypoxia-Induced FAM13A Regulates the Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells. International journal of molecular sciences 19 33919074
2021 Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors. EBioMedicine 19 34224973
2020 FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism. iScience 18 32151973
2018 The rs2609255 polymorphism in the FAM13A gene is reproducibly associated with silicosis susceptibility in a Chinese population. Gene 18 29621588
2017 FAM13A as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer. Journal of Cancer 18 29187867
2022 LncRNA FAM13A-AS1 Regulates Proliferation and Apoptosis of Cervical Cancer Cells by Targeting miRNA-205-3p/DDI2 Axis. Journal of oncology 14 35783157
2019 Functional Variant in 3'UTR of FAM13A Is Potentially Associated with Susceptibility and Survival of Lung Squamous Carcinoma. DNA and cell biology 14 31539274
2018 Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity. International journal of obesity (2005) 14 30301961
2021 FAM13A as potential therapeutic target in modulating TGF-β-induced airway tissue remodeling in COPD. American journal of physiology. Lung cellular and molecular physiology 13 34105356
2021 A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract. Frontiers in physiology 13 34163376
2019 The Molecular Characteristics of the FAM13A Gene and the Role of Transcription Factors ACSL1 and ASCL2 in Its Core Promoter Region. Genes 13 31795267
2018 Genetic variants in FAM13A and IREB2 are associated with the susceptibility to COPD in a Chinese rural population: a case-control study. International journal of chronic obstructive pulmonary disease 13 29872291
2022 LncRNA FAM13A-AS1 Promotes Renal Carcinoma Tumorigenesis Through Sponging miR-141-3p to Upregulate NEK6 Expression. Frontiers in molecular biosciences 10 35402517
2016 IREB2, CHRNA5, CHRNA3, FAM13A & hedgehog interacting protein genes polymorphisms & risk of chronic obstructive pulmonary disease in Tatar population from Russia. The Indian journal of medical research 10 28474623
2015 Identification of FAM13A gene associated with the ratio of FEV1 to FVC in Korean population by genome-wide association studies including gene-environment interactions. Journal of human genetics 10 25608829
2014 Quantitative analysis of lungs and airways with CT in subjects with the chronic obstructive pulmonary disease (COPD) candidate FAM13A gene: case control study for CT quantification in COPD risk gene. Journal of computer assisted tomography 10 24651745
2021 Connecting COPD GWAS Genes: FAM13A Controls TGFβ2 Secretion by Modulating AP-3 Transport. American journal of respiratory cell and molecular biology 9 34166600
2021 miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia. Molecular medicine reports 9 34821370
2019 High expression of FAM13A was associated with increasing the liver cirrhosis risk. Molecular genetics & genomic medicine 9 30604588
2019 Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk. Current molecular medicine 9 31215377
2023 AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex. American journal of respiratory cell and molecular biology 7 36749583
2023 FAM13A regulates cellular senescence marker p21 and mitochondrial reactive oxygen species production in airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology 7 37605846
2023 FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers. BMC cancer 6 37391706
2024 The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport. American journal of respiratory cell and molecular biology 5 38691660
2023 LncRNA FAM13A-AS1, transcriptionally regulated by PHOX2B, modulates hepatocellular carcinoma chemoresistance via stabilizing PPARγ. Gene 5 37330023
2020 Two-hybrid screening of FAM13A protein partners in lung epithelial cells. BMC research notes 5 31900205
2012 Polymorphism of the FAM13A, ABCG2, OPN, LAP3, HCAP-G, PPARGC1A genes and somatic cell count of Jersey cows--preliminary study. Research in veterinary science 5 23021125
2025 FAM13A polymorphism is associated with a usual interstitial pneumonia pattern in patients with systemic sclerosis-associated interstitial lung disease. Rheumatology (Oxford, England) 4 39418199
2021 FAM13A promotes proliferation of bovine preadipocytes by targeting Hypoxia-Inducible factor-1 signaling pathway. Adipocyte 4 34672860
2024 Molecular Characterizations of FAM13A and Its Functional Role in Inhibiting the Differentiation of Goat Intramuscular Adipocytes through RIG-I Receptor Signaling Pathway. Genes 3 39336734
2023 Single Nucleotide Polymorphisms of FAM13A Gene in Chronic Obstructive Pulmonary Disease-A Case Control Study in Vietnam. Advances in respiratory medicine 3 37366807
2021 rs6837671A>G in FAM13A Is a Trans-Ethnic Genetic Variant Interacting with Vitamin D Levels to Affect Chronic Obstructive Pulmonary Disease. Journal of personalized medicine 1 33573279
2026 Long isoforms of the COPD risk gene FAM13A orchestrate human lung epithelial development. American journal of respiratory cell and molecular biology 0 42083809
2025 Exploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: a study of protein interactions and molecular dynamics simulations. BMC cancer 0 40087586
2025 A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 0 40531729
2025 Association of FAM13A single-nucleotide polymorphism with spirometry indices and pulmonary ventilation characteristics in patients with chronic obstructive pulmonary disease. The Journal of international medical research 0 40891807
2023 The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women. Genes 0 37107672

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