Affinage

FABP7

Fatty acid-binding protein, brain · UniProt O15540

Length
132 aa
Mass
14.9 kDa
Annotated
2026-04-28
100 papers in source corpus 39 papers cited in narrative 40 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FABP7 is an intracellular fatty acid-binding protein that functions as a lipid chaperone in radial glia, astrocytes, and neural stem/progenitor cells, coupling fatty acid transport to nuclear signaling, epigenetic regulation, and inflammatory responses. FABP7 binds long-chain polyunsaturated fatty acids (DHA, oleic acid, arachidonic acid) in a β-barrel pocket and delivers them to membranes via a portal-region-mediated collisional mechanism; ligand identity dictates conformational changes near the nuclear localization signal, directing subcellular trafficking of the FABP7–fatty acid complex to the nucleus where it interacts with ACLY to regulate acetyl-CoA levels and histone acetylation at targets including caveolin-1 (PMID:23555925, PMID:36698315, PMID:34196621, PMID:32812201, PMID:36325660). In development, FABP7 acts downstream of Pax6 and is repressed by REV-ERBα, maintaining neural stem cell proliferation and regulating oligodendrocyte progenitor differentiation; its loss causes premature neuronal differentiation, disrupted dendritic morphology, and reduced excitatory synaptic function through astrocyte-dependent mechanisms (PMID:16237179, PMID:34056625, PMID:26296243, PMID:22581784). FABP7 activates NF-κB-driven neuroinflammation in a ligand-binding-dependent manner, promotes lipid droplet formation that sequesters reactive oxygen species, and regulates sleep through a conserved astrocytic lipid-signaling pathway disrupted by the human T61M missense variant (PMID:40251832, PMID:32619303, PMID:30680690, PMID:28435883).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1994 High

    The discovery that FABP7 (BLBP) is a brain-specific lipid-binding protein localizing to both nucleus and cytoplasm of radial glia, and that its antibody-mediated blockade disrupts the radial glial fiber system, established FABP7 as a functional mediator of glial differentiation rather than a passive lipid carrier.

    Evidence Immunoelectron microscopy for subcellular localization, anti-BLBP antibody blockade in primary brain cell cultures

    PMID:8161459

    Open questions at the time
    • Identity of the endogenous lipid ligand was unknown
    • Mechanism linking lipid binding to radial glial fiber formation was not defined
    • Nuclear function was not explored
  2. 2005 High

    Placing FABP7 downstream of Pax6 and showing that its knockdown causes premature neuronal differentiation established FABP7 as a transcriptionally regulated effector maintaining neural stem/progenitor cell proliferation.

    Evidence In vivo electroporation of siRNA in embryonic rat cortex with BrdU proliferation assay; Pax6 overexpression inducing Fabp7

    PMID:16237179

    Open questions at the time
    • Whether FABP7 is a direct versus indirect Pax6 target was not resolved at this stage
    • Downstream lipid-dependent effectors of proliferation maintenance were unknown
  3. 2007 High

    Fabp7 knockout mice exhibiting decreased prepulse inhibition and disrupted neurogenesis linked FABP7 to NMDA receptor-related circuits and sensorimotor gating, broadening its role from development to postnatal brain function.

    Evidence QTL analysis, Fabp7 KO mouse behavioral phenotyping, BrdU neurogenesis assay, quantitative complementation

    PMID:18001149

    Open questions at the time
    • Whether the PPI deficit is cell-autonomous to glia or neurons was unclear
    • Molecular pathway from FABP7 to NMDA receptor signaling was not defined
  4. 2008 Medium

    The observation that Fabp7 mRNA and protein undergo diurnal oscillations in adult astrocytes, peaking at opposite phases, suggested post-transcriptional regulation and a role in circadian brain physiology.

    Evidence RNA and protein time-course analysis across 24 h in adult mouse brain by in situ hybridization and immunoblot

    PMID:18286188

    Open questions at the time
    • Transcriptional versus post-transcriptional basis of oscillation was not resolved
    • Functional consequence of diurnal FABP7 cycling was not tested
  5. 2012 High

    Multiple studies converged to show that FABP7 mRNA undergoes CPEB1-dependent polyadenylation for perisynaptic localization in astrocytes, that PAX6 directly transactivates the FABP7 promoter, and that FABP7 maintains neural stem cell proliferation in the adult hippocampus, integrating transcriptional, post-transcriptional, and stem cell biology dimensions.

    Evidence Co-IP of Fabp7 mRNA with CPEB1, Xenopus CPE reporter assay, PAX6 promoter deletion/gel shift, Fabp7 KO hippocampal BrdU assays

    PMID:22279223 PMID:22581784 PMID:22583899

    Open questions at the time
    • Whether CPEB1-dependent translation directly regulates perisynaptic lipid metabolism was not shown
    • Full set of transcription factors controlling FABP7 expression was incomplete
  6. 2013 High

    Biophysical and structural studies demonstrated that FABP7 delivers fatty acids to membranes via a portal-region collisional mechanism, with helices αI/αII undergoing conformational rearrangement, providing the first mechanistic model for FABP7-mediated lipid transfer.

    Evidence Site-directed mutagenesis, ESR spectroscopy with spin-labeled mutants and lipid probes

    PMID:23555925

    Open questions at the time
    • Whether the collisional mechanism operates identically at nuclear versus plasma membranes was untested
    • Kinetic parameters of transfer for different FA species were not measured
  7. 2014 High

    ChIP and KO data established REV-ERBα as a direct transcriptional repressor of Fabp7 in the brain, connecting clock machinery to FABP7-driven progenitor proliferation and providing a molecular link between circadian regulation and neurogenesis.

    Evidence Rev-erbα KO mouse, promoter ChIP-seq, cell proliferation assays

    PMID:24932636 PMID:34056625

    Open questions at the time
    • Whether REV-ERBα repression accounts for the full diurnal FABP7 oscillation was not resolved
    • Other circadian regulators of FABP7 were not excluded
  8. 2015 High

    Demonstrating that FABP7-KO astrocytes impair dendritic morphology, spine density, and excitatory synaptic transmission of co-cultured neurons — with partial rescue by WT astrocyte transplantation — established FABP7 as an astrocytic regulator of neuronal circuit structure and function.

    Evidence Fabp7 KO mice, Golgi staining, neuron-astrocyte co-culture, mEPSC recording, astrocyte transplantation in mPFC

    PMID:26296243

    Open questions at the time
    • The secreted or contact-dependent astrocytic signal was not identified
    • Whether specific FABP7-transported lipids mediate the synaptic effects was unknown
  9. 2017 High

    The T61M missense variant's association with fragmented sleep in humans, mice, and Drosophila — with astrocyte-specific expression in flies — established FABP7 as part of a phylogenetically conserved astrocytic lipid-signaling pathway regulating sleep.

    Evidence Human genotype-phenotype association, Fabp7 KO mouse EEG/EMG, transgenic Drosophila expressing FABP7.T61M in glia

    PMID:28435883

    Open questions at the time
    • Downstream lipid signals mediating sleep consolidation were not identified
    • Whether the T61M mutation alters ligand binding specificity or affinity was not structurally resolved
  10. 2019 High

    FABP7 was shown to promote lipid droplet formation that protects astrocytes from ROS toxicity via thioredoxin signaling, and to support glycolytic reprogramming in HER2+ breast cancer brain metastasis, linking its lipid-shuttling function to metabolic stress responses.

    Evidence FABP7 KO astrocytes with ROS induction and LD quantification; FABP7 KD/OE in HER2+ cells with metabolic assays and intracranial xenograft

    PMID:30680690 PMID:31324889

    Open questions at the time
    • Whether LD-mediated ROS protection requires specific FA species was untested
    • Direct lipid cargo in cancer metabolic reprogramming was not identified
  11. 2020 High

    Discovery that FABP7 interacts with ACLY in the nucleus and modulates histone acetylation (including H3K27ac at the caveolin-1 promoter) revealed an epigenetic effector function, while ligand-binding-dependent NF-κB activation in astrocytes linked FABP7 to neuroinflammation in ALS models.

    Evidence Co-IP of FABP7–ACLY, histone acetylation ChIP, FABP7 OE/KO in astrocytes, NF-κB reporter, ligand-binding mutant control, hSOD1 astrocyte co-culture

    PMID:32619303 PMID:32812201

    Open questions at the time
    • Whether ACLY interaction requires a specific lipid ligand was not resolved
    • Structural basis of FABP7–ACLY interaction was unknown
    • Whether NF-κB activation is direct or mediated through ACLY/acetyl-CoA was not distinguished
  12. 2021 High

    Crystal structures of FABP7 with different fatty acids and NMR/MD studies showing ligand-dependent conformational changes near the NLS provided a structural explanation for how lipid identity directs FABP7's nuclear versus cytoplasmic distribution, and ligand-bound FABP7 was shown to activate Wnt/β-catenin signaling in melanoma.

    Evidence X-ray crystallography at 1.6 Å, NMR spectroscopy, MD simulations, mutagenesis; Wnt/β-catenin reporter with WT vs. FA-binding-site mutant FABP7, MF6 pharmacological inhibition

    PMID:33646504 PMID:34196621 PMID:36698315

    Open questions at the time
    • Structural basis for NLS exposure upon specific ligand binding remains at simulation level
    • Whether Wnt activation is direct or through β-catenin degradation complex competition was not fully resolved at this point
  13. 2022 High

    Oleic acid-bound FABP7 was shown to drive nuclear lipid droplet formation colocalizing with PML bodies and enhancing histone acetylation-dependent proliferative gene expression, providing a complete mechanistic chain from ligand binding through nuclear LD to epigenetic transcriptional control.

    Evidence FABP7 OE with OA, nuclear LD and PML body colocalization imaging, histone acetylation assay, mRNA profiling, FABP7 FA-binding mutant control

    PMID:36325660

    Open questions at the time
    • Whether nuclear LD formation requires ACLY-dependent acetyl-CoA was not directly tested in this study
    • PML body functional requirement was not confirmed by PML loss-of-function
  14. 2023 High

    FABP7's pro-inflammatory NF-κB activation was validated in human iPSC-derived astrocytes with RNA-seq and shown to require fatty acid binding, while FABP7 was also found to form toxic hetero-aggregates with α-synuclein that accumulate in oligodendrocytes via epsin-2-dependent endocytosis, extending FABP7's pathological roles to Alzheimer's and multiple system atrophy.

    Evidence FABP7 OE in iPSC astrocytes with RNA-seq and ligand-binding mutant; FABP7/αSyn hetero-aggregate injection in MSA mouse models, AAV5-epsin-2 KD rescue

    PMID:37082980 PMID:37688656

    Open questions at the time
    • Which specific FA species drive NF-κB activation in human astrocytes was not determined
    • Whether FABP7/αSyn aggregation is relevant in sporadic Parkinson's disease was not tested
  15. 2024 High

    FABP7 deficiency in ASD patient-derived cerebral organoids caused premature neural differentiation rescued by MEK pathway modulation, and Fabp7-KD mice exhibited ASD-like behaviors, establishing FABP7/MEK as a functional axis in autism-relevant neural development.

    Evidence iPSC-derived cerebral organoids, scRNA-seq time series, FABP7/MEK pathway rescue, Fabp7 KD mouse behavioral phenotyping

    PMID:39556706

    Open questions at the time
    • Whether FABP7 directly activates MEK or acts through an intermediate lipid signal was not resolved
    • Genetic variants in FABP7 causative for ASD in families were not identified
  16. 2025 High

    Extracellular FABP7 was shown to reprogram monocyte metabolism toward glycolysis and inflammation, while intracellular FABP7 in hepatic macrophages modulates PPARγ-dependent M2 polarization, and astrocytic FABP7 silencing attenuates NF-κB-p65 nuclear translocation in vivo, consolidating FABP7 as a lipid-dependent inflammatory mediator across cell types.

    Evidence In vitro monocyte treatment with extracellular FABP7, FABP7 KO in hepatic fibrosis model with PPARγ inhibitor, astrocytic FABP7 siRNA in vivo with LPS challenge and RNA-seq

    PMID:40017805 PMID:40251832 PMID:40595541

    Open questions at the time
    • Receptor or uptake mechanism for extracellular FABP7 on monocytes is unknown
    • Whether PPARγ and NF-κB pathways are independently or sequentially activated by FABP7 is unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the identity of specific lipid species that dictate FABP7's nuclear versus cytoplasmic function in vivo; the structural basis of the FABP7–ACLY interaction; the receptor or mechanism for extracellular FABP7 uptake; and whether FABP7-dependent sleep regulation operates through the same NF-κB/epigenetic axis identified in neuroinflammation.
  • No structural model of FABP7–ACLY complex exists
  • Lipid species specificity for each downstream pathway is undefined in vivo
  • Mechanism linking FABP7 to sleep at the molecular level is uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 6 GO:0008289 lipid binding 5 GO:0140104 molecular carrier activity 2
Localization
GO:0005634 nucleus 5 GO:0005811 lipid droplet 3 GO:0005829 cytosol 2 GO:0005576 extracellular region 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1266738 Developmental Biology 5 R-HSA-168256 Immune System 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1430728 Metabolism 4 R-HSA-4839726 Chromatin organization 3
Partners
ACLYCPEB1CTNNB1NR1D1PAX6PPARGSNCA

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 BLBP (FABP7) is a brain-specific lipid-binding protein expressed in radial glia that localizes to both nucleus and cytoplasm, and is required for establishment of the radial glial fiber system in developing brain; antibody-mediated blockade of BLBP disrupts glial and neuronal differentiation in primary cell cultures without affecting proliferation or adhesion. Immunoelectron microscopy (subcellular localization), anti-BLBP antibody blockade in primary cell cultures (functional loss-of-function), in situ hybridization and immunocytochemistry (expression pattern) Neuron High 8161459
2005 Fabp7 is a downstream transcriptional target of Pax6 in the developing rat cortex; Fabp7 siRNA knockdown curtails neuroepithelial cell proliferation and promotes premature neuronal differentiation, demonstrating Fabp7 is required for maintenance of neuroepithelial cells. Microarray followed by quantitative PCR (expression), electroporation of siRNA in embryonic rat cortex (in vivo loss-of-function), Pax6 overexpression (gain-of-function), BrdU proliferation assay The Journal of neuroscience High 16237179
2007 Fabp7-deficient mice show decreased prepulse inhibition and disrupted neurogenesis in vivo, placing Fabp7 in a pathway linking NMDA receptor signaling, glial function, and sensorimotor gating; genetic complementation test supported Fabp7 as the QTL gene. QTL analysis, Fabp7 knockout mice behavioral phenotyping (PPI assay), BrdU neurogenesis assay, quantitative complementation test PLoS biology High 18001149
2003 PKNOX1 (PREP1), a transcription factor encoded on chromosome 21, directly binds the Pbx/POU site of the FABP7 promoter in vitro and transactivates FABP7 promoter activity in neuroblastoma cells, linking chromosome 21 gene-dosage imbalance in Down syndrome to FABP7 overexpression. Genomic inverse PCR (promoter cloning), in vitro binding assay (PKNOX1 binding to FABP7 promoter), transfection/promoter transactivation assay in neuroblastoma cells, real-time PCR Nucleic acids research Medium 12771203
2008 Brain fatty acid-binding protein Fabp7 mRNA and protein levels undergo diurnal oscillations throughout adult mouse brain, with mRNA peaking during the light period and protein peaking during the dark period; this diurnal rhythm is present in astrocytes and hippocampal granule cell precursors but is absent in immature postnatal brain where astrocytes are not yet mature. RNA analysis, in situ hybridization, immunoblot (diurnal expression profiling across 24 h in adult and postnatal mouse brain) PloS one Medium 18286188
2011 FABP7 is required for astrocyte proliferation following brain stab injury; FABP7-KO astrocytes show decreased proliferation and reduced omega-3 fatty acid incorporation, linking FABP7 to cellular fatty acid homeostasis in reactive gliosis. Mouse cortical stab injury model, Western blot, immunohistochemistry, BrdU proliferation assay in FABP7-KO vs wild-type mice, primary astrocyte culture from KO mice Histochemistry and cell biology High 21938553
2012 Fabp7 and Fabp5 are differentially expressed in postnatal hippocampal neural stem/progenitor cells; Fabp7 KO reduces NSC/NPC proliferation and BrdU uptake while enhancing neuronal differentiation in the subgranular zone of the dentate gyrus. Immunofluorescence, BrdU pulse-chase assay, Fabp7 KO / Fabp5 KO / double-KO mouse analysis Stem cells (Dayton, Ohio) High 22581784
2012 FABP7 mRNA localizes to the astrocytic perisynaptic compartment and undergoes diurnal changes in intracellular distribution; Fabp7 mRNA co-immunoprecipitates with CPEB1 from primary astrocyte extracts, and its 3'UTR contains functional cytoplasmic polyadenylation elements (CPEs) capable of regulating mRNA translation, implicating circadian/sleep-dependent polyadenylation in subcellular trafficking of Fabp7 mRNA to perisynaptic processes. Northern blotting (poly(A) tail analysis), co-immunoprecipitation of Fabp7 mRNA with CPEB1 from astrocyte extracts, Xenopus oocyte maturation reporter assay (CPE function), in situ hybridization, subcellular fractionation The Journal of neuroscience High 22279223
2012 FABP7 is a direct binding target of the neural stem cell-specific fluorescent probe CDr3 (a BODIPY derivative), identified by proteomic analysis; CDr3 binds FABP7 in the cytoplasm of living neural stem cells and can be used to isolate FABP7-high cells with neural stem cell properties. High-throughput fluorescence library screening, proteomic identification of binding target, live cell imaging, FACS isolation, neurosphere formation and differentiation assays Proceedings of the National Academy of Sciences of the United States of America High 22689954
2012 PAX6 directly transactivates the FABP7 proximal promoter; PAX6 knockdown in PAX6-positive malignant glioma cells reduces FABP7 levels, and a PAX6-responsive element was mapped to -862 to -1033 bp upstream of FABP7 by sequential deletion and gel shift/supershift assays. CAT reporter gene assay, sequential promoter deletion analysis, gel shift and supershift assays, PAX6 siRNA knockdown Biochemical and biophysical research communications Medium 22583899
2013 FABP7 interacts with model membranes through its portal region (helices A1 and A2 and connecting loop), delivering polyunsaturated fatty acids via a collisional mechanism; site-directed mutagenesis and ESR spectroscopy showed that portal region residues undergo structural changes upon membrane interaction, with residues pointing outward decreasing in mobility and inner residues increasing in mobility to facilitate FA delivery. Site-directed mutagenesis, electron spin resonance (ESR) spectroscopy with spin-labeled protein mutants and lipid probes, lipidic micelle model membranes PloS one High 23555925
2013 FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells: FABP7 is expressed in NG2+/PDGFRα+ oligodendrocyte progenitor cells (OPCs) while FABP5 marks mature oligodendrocytes; FABP7-KO OPCs show decreased proliferation and reduced differentiation into O4+ oligodendrocytes. Immunofluorescence co-staining with lineage markers in vivo and in vitro, BrdU proliferation assay, FABP7-KO and FABP5-KO OPC cultures, oligodendrocyte differentiation medium Cell and tissue research High 24114376
2014 REV-ERBα (Nr1d1) directly represses Fabp7 gene expression in the brain; loss of Rev-erbα results in Fabp7 overexpression in multiple brain areas including the hippocampal subgranular zone, leading to increased proliferation of hippocampal neuronal progenitors and loss of diurnal proliferation patterns. Rev-erbα KO mouse gene expression comparison, in vitro cell proliferation and migration assays with Fabp7 manipulation and REV-ERBα activity modulation PloS one Medium 24932636
2014 A distinct chimeric FABP7 isoform (LTR2-FABP7) is ectopically expressed in a subset of diffuse large B-cell lymphoma through activation of an endogenous retroviral LTR2 promoter; this isoform is required for DLBCL cell line proliferation and growth. Whole transcriptome reanalysis, RT-PCR confirmation in DLBCL cell lines, in vitro siRNA knockdown with proliferation readout Proceedings of the National Academy of Sciences of the United States of America Medium 25114248
2015 Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons; FABP7 KO astrocytes cause aberrant dendritic morphology, decreased spine density, reduced excitatory synapse number, and decreased mEPSC amplitude and frequency in mPFC pyramidal neurons; transplantation of WT astrocytes into the mPFC of KO mice partially rescued behavioral impairments. Fabp7 KO mice, Golgi staining, primary co-culture of neurons with KO astrocytes, conditioned medium experiments, whole-cell voltage-clamp recording (mEPSC), astrocyte transplantation Glia High 26296243
2016 DHA stimulates FABP7 expression in astrocytes via a PI3K/AKT-PPARγ axis; FABP7 then interacts physically with PPARγ (detected as protein-protein complex), displacing CDK5-PPARγ complex and leading to increased GFAP expression; FABP7 silencing suppresses DHA-induced GFAP upregulation. Primary rat brain astrocyte cultures, siRNA knockdown, PI3K/AKT and PPARγ inhibitor treatments, co-immunoprecipitation (FABP7-PPARγ and CDK5-PPARγ complexes), PPARγ-responsive element reporter assay Journal of neurochemistry Medium 27787894
2017 FABP7 (Fabp7) is required for normal sleep across phylogenetically disparate species; the FABP7.T61M missense mutation is associated with fragmented sleep in humans and recapitulated in mice and Drosophila; transgenic flies expressing FABP7.T61M in astrocytes show fragmented sleep, establishing FABP7 as part of a conserved astrocytic lipid-signaling pathway regulating sleep. Human sleep phenotyping (missense mutation association), Fabp7-deficient mice sleep analysis (EEG/EMG), Drosophila transgenic lines expressing FABP7.T61M in glia (sleep monitoring) Science advances High 28435883
2018 FABP7 can be regulated by PKC and the MAPK/ERK1/2 pathway in melanoma cells (PMA or MEK1 inhibitor downregulates FABP7); siRNA knockdown of FABP7 decreases melanoma cell proliferation and invasion without affecting apoptosis. PMA and MEK1 inhibitor (PD98059) treatment, siRNA knockdown, proliferation and invasion assays in human melanoma cell lines BMC cancer Medium 18826602
2018 Glial FABP7 in hypothalamic astrocytes/tanycytes modulates neuronal leptin sensitivity; FABP7-KO mice show enhanced leptin-induced activation of ARC neurons (increased pSTAT3+ cells) and reduced weight gain on high-fat diet; primary FABP7-KO astrocytes display lower ERK phosphorylation after leptin treatment. FABP7 KO mice, diet-induced obesity model, leptin injection, immunohistochemistry (pSTAT3), primary astrocyte cultures with leptin treatment (ERK phosphorylation) Molecular neurobiology Medium 29623545
2019 FABP7 drives metabolic reprogramming in HER2+ breast cancer brain metastasis by supporting a glycolytic phenotype and lipid droplet storage; FABP7 is required for upregulation of integrin-Src and VEGFA pathways and for in vivo tumor growth in the brain microenvironment. FABP7 knockdown and overexpression in HER2+ breast cancer cells, in vitro metabolic assays, in vivo intracranial xenograft model, pathway analysis Oncogene Medium 31324889
2019 FABP7 protects astrocytes from ROS toxicity through lipid droplet (LD) formation; FABP7-KO astrocytes show significantly decreased LD accumulation, elevated ROS toxicity, impaired thioredoxin signaling, and activation of pro-apoptotic p38 MAPK and SAPK/JNK pathways; FABP7 overexpression in glioma cells increases LD accumulation and antioxidant enzyme expression. FABP7-KO primary mouse astrocytes, ROS induction, LD quantification, Western blot (TRX, PRX1, p38 MAPK, SAPK/JNK, caspase-3), NAC rescue, FABP7 overexpression in U87 cells Molecular neurobiology High 30680690
2020 FABP7 overexpression in astrocytes induces an NF-κB-driven pro-inflammatory response that is detrimental for motor neuron survival; silencing FABP7 in astrocytes from symptomatic hSOD1-expressing mice decreases inflammatory markers and reduces toxicity toward co-cultured motor neurons; a ligand-binding impaired mutant FABP7 does not induce NF-κB activation. FABP7 overexpression in non-transgenic astrocytes, astrocyte-motor neuron co-culture, siRNA knockdown, NF-κB reporter assay, hSOD1 transgenic mouse astrocyte cultures, mutant FABP7 (ligand-binding impaired) Glia High 32619303
2020 FABP7 interacts with ATP-citrate lyase (ACLY) in the nucleus and is important for acetyl-CoA metabolism; the FABP7-ACLY interaction modulates nuclear histone acetylation and thereby epigenetically regulates caveolin-1 expression in astrocytes and glioma cells. Co-immunoprecipitation (FABP7-ACLY interaction), FABP7-KO primary astrocytes, NIH-3T3 gain-of-function model, histone acetylation assay, caveolin-1 promoter analysis Molecular neurobiology High 32812201
2020 FABP7 is required for optimal OPC differentiation during developmental myelination but is dispensable for remyelination; Fabp7 knockdown reduces OPC differentiation in vitro and Fabp7 KO mice show a transient delay in developmental myelination that resolves before adulthood. Fabp7 siRNA knockdown in OPC cultures, Fabp7 KO mouse developmental myelination analysis, focal demyelination model (remyelination assay) Glia Medium 32017258
2021 Rev-erbα directly binds the Fabp7 promoter in multiple brain areas (hippocampus, hypothalamus, VTA) as shown by ChIP-seq, and Fabp7 gene expression is specifically and robustly upregulated (>6-fold across all brain regions) in Rev-erbα KO mice, establishing Rev-erbα as a direct transcriptional repressor of Fabp7. ChIP-seq (Rev-erbα binding at Fabp7 promoter), Rev-erbα KO mouse, quantitative mRNA analysis across multiple brain areas Current research in neurobiology High 34056625
2021 Ligand-bound FABP7 drives melanoma cell proliferation via activation of Wnt/β-catenin signaling; wild-type FABP7 overexpression increases Wnt/β-catenin activity (luciferase reporter), cyclin D1 expression, and proliferation, while a FA-binding site mutant FABP7 abrogates these effects; pharmacological inhibition of FABP7 with MF6 suppresses these responses. FABP7 siRNA knockdown and OE with wild-type vs. mutant FABP7, Wnt/β-catenin luciferase reporter assay, proliferation and migration assay, MF6 pharmacological inhibition Pharmaceutical research High 33646504
2021 FABP7 facilitates uptake of DHA in GBM neural stem-like cells; FABP7 knockdown reduces DHA incorporation into GBM cells and diminishes DHA-induced inhibition of cell migration. FABP7 knockdown in patient-derived GBM neurosphere cultures, fatty acid composition analysis (lipidomics), migration assay Nutrients Medium 34444824
2021 Nuclear FABP7 promotes glioblastoma cell proliferation in IDH1-wild-type glioma through caveolae formation; FABP7wt overexpression increases caveolin-1 expression and caveolae/caveosome formation via elevated H3K27ac on the caveolin-1 promoter through ACLY-dependent nuclear acetyl-CoA regulation; mutant FABP7 (FA-binding impaired) abrogates these effects in vitro and in xenograft models. FABP7wt and FABP7mut overexpression in U87 cells, caveolae/caveosome visualization, H3K27ac ChIP on caveolin-1 promoter, nuclear acetyl-CoA measurement, in vivo xenograft, patient GBM tissue analysis Molecular oncology High 34716958
2021 NMR and molecular dynamics simulations demonstrate that FABP7 has high conformational heterogeneity that is substantially reduced upon fatty acid ligand binding; DHA binding leads to chemical shift perturbations in residues near the nuclear localization signal, suggesting a mechanism for differential nuclear vs. cytoplasmic transport depending on ligand identity; ligand binding is resistant to mutations in polar binding pocket residues. NMR spectroscopy, multiscale molecular dynamics simulations, site-directed mutagenesis of binding pocket residues, biophysical binding assays Biophysical journal High 36698315
2021 Crystal structure of human FABP7 complexed with palmitic acid (a saturated FA) at 1.6 Å resolution reveals a U-shaped binding conformation; the carboxylate of palmitic acid interacts with Tyr129, Arg127, and via water bridge with Arg107 and Thr54, while the aliphatic chain is stabilized by hydrophobic interactions with Met21, Leu24, Thr30, Thr37, Pro39, Phe58, and Asp77; PA, OA, and DHA adopt distinct binding conformations in the pocket. X-ray crystallography (1.6 Å resolution), structural comparison with OA- and DHA-bound FABP7 and other FABP family members Acta crystallographica. Section D, Structural biology High 34196621
2022 Oleic acid-bound FABP7 drives glioma cell proliferation by promoting nuclear localization of the FABP7-OA complex, inducing nuclear lipid droplet (nLD) formation, increasing colocalization of nLD with PML nuclear bodies, and enhancing histone acetylation-dependent transcription of proliferation-related genes; FA-binding site mutant FABP7 abrogates all these effects. OA treatment of FABP7-expressing cells, FABP7 nuclear localization imaging, nLD visualization, PML body co-localization, histone acetylation assay, mRNA profiling, FABP7-KO and FABP7-mutant overexpression controls The FEBS journal High 36325660
2022 FABP7 promotes NSCLC metastasis by competitively inhibiting the interaction between β-catenin and its cytoplasmic degradation complex, thereby repressing phosphorylation-dependent ubiquitination and degradation of β-catenin and activating canonical Wnt signaling. FABP7 KD and OE in NSCLC cell lines, in vivo metastasis model, co-immunoprecipitation (β-catenin with degradation complex), β-catenin phosphorylation and ubiquitination assays Cells Medium 35269427
2023 Wild-type FABP7 overexpression induces an NF-κB-driven inflammatory response in human iPSC-derived astrocytes (identified by RNA-seq as top biological process); a ligand-binding impaired mutant FABP7 does not activate NF-κB, demonstrating that FABP7's pro-inflammatory function requires its fatty acid-binding activity; amyloid-β treatment induces FABP7 upregulation in primary hippocampal astrocytes. FABP7 OE in human iPSC-derived astrocytes, whole transcriptome RNA-seq, Gene Ontology analysis, NF-κB reporter assay, ligand-binding mutant FABP7 control, Aβ treatment of primary astrocytes, APP/PS1 mouse immunostaining GeroScience High 37688656
2023 FABP7 forms hetero-aggregates with α-synuclein (αSyn) that exhibit stronger toxicity than αSyn aggregates alone; injected FABP7/αSyn hetero-aggregates selectively accumulate in oligodendrocytes and Purkinje neurons causing cerebellar dysfunction; epsin-2 regulates FABP7/αSyn hetero-aggregate propagation via clathrin-dependent endocytosis, and epsin-2 knockdown decreases αSyn aggregate accumulation and improves motor performance. MSA mouse models (PLP-hαSyn, FABP7/αSyn hetero-aggregate injection), co-aggregation assays, AAV5-dependent epsin-2 knockdown, histology, motor function testing, bioinformatic analysis of MSA patient whole blood Brain : a journal of neurology High 37082980
2023 FABP7 binds oleic acid and DHA micelles through its portal region residues; NMR and molecular dynamics simulations reveal that binding to micelles occurs through the same portal region as membrane binding, and simulations capture fatty acid dissociation from membranes directly entering FABP7's binding pocket. NMR spectroscopy, multiscale molecular dynamics simulations, biophysical binding assays with OA and DHA micelles Biophysical journal High 36698315
2024 FABP7 deficiency in iPSC-derived cerebral organoids from normocephalic ASD individuals causes premature neural differentiation of neural stem cells; altered phosphorylation of MEK1/2 (downstream of FABP7) was detected, and regulation of the FABP7/MEK pathway reversed improper neural differentiation; Fabp7 knockdown and MEK2-overexpressing mice exhibit repetitive stereotyped behaviors and social defects. iPSC-derived cerebral organoids from ASD patients, single-cell RNA-seq (time series), FABP7 loss-of-function rescue experiments via FABP7/MEK pathway modulation, Fabp7 KD mice behavioral phenotyping (open field, social interaction) Advanced science (Weinheim, Baden-Wurttemberg, Germany) High 39556706
2025 FABP7 in hepatic macrophages modulates M2 polarization via PPARγ and its target genes (CCL17, TGF-β); FABP7-deficient macrophages display decreased PPARγ activity, reduced fibrotic response of myofibroblasts, and decreased CD4+ T-cell migration into liver; in vitro, IL-4-stimulated FABP7-deficient macrophages show reduced CCL-17 and TGF-β, effects blocked by PPARγ inhibitor. FABP7 KO in CCl4-induced hepatic fibrosis model, in vitro macrophage polarization assays, PPARγ inhibitor treatment, co-culture of macrophages with CD4+ T cells and hepatic stellate cells Journal of immunology research Medium 40017805
2025 Extracellular FABP7 induces a pro-inflammatory phenotype in monocytes via increased glycolysis, upregulating CD16, CD80 and IL-1β; FABP7-induced gene expression in monocytes reflects enhanced inflammation, chemotaxis, and glucose metabolism. In vitro FABP7 treatment of monocytes, flow cytometry (CD16, CD80), ELISA (IL-1β), transcriptomics, glycolysis assays; patient serum/CSF FABP7 measurement Nature communications Medium 40595541
2025 FABP7 silencing in astrocytes decreases NF-κB-p65 nuclear translocation and NF-κB reporter activity in response to multiple inflammatory stimuli, reduces astrocyte toxicity toward motor neurons, and reduces glial activation in vivo after LPS administration; whole transcriptome RNA-seq confirms attenuation of NF-κB-dependent transcriptional response. FABP7 siRNA in primary mouse and human iPSC-derived astrocytes, NF-κB reporter assay, NF-κB-p65 nuclear translocation imaging, astrocyte-motor neuron co-culture, in vivo astrocytic FABP7 knockdown in LPS-treated mice, RNA-seq Glia High 40251832
2026 YRDC-catalyzed tRNA t6A modification drives codon-biased translation of FABP7 mRNA; elevated FABP7 induces lipid droplet accumulation that sequesters TMZ-induced ROS to confer chemoresistance in glioblastoma; YRDC inhibition suppresses FABP7 translation and lipid droplets, synergizing with TMZ in vitro and in orthotopic xenografts. YRDC KD/OE, polysome profiling/ribosome profiling (codon-biased translation), lipid droplet quantification, ROS assays, in vitro and in vivo (PDX) TMZ resistance models, YRDC inhibitor (HY-Q66655) virtual screening and functional validation Oncogene Medium 42014887

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS. Neuron 488 8161459
2007 Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS biology 168 18001149
2005 Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 138 16237179
2012 A radial glia gene marker, fatty acid binding protein 7 (FABP7), is involved in proliferation and invasion of glioblastoma cells. PloS one 99 23284888
2015 Astrocyte-expressed FABP7 regulates dendritic morphology and excitatory synaptic function of cortical neurons. Glia 92 26296243
2014 The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. PloS one 92 24932636
2012 The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse. Stem cells (Dayton, Ohio) 92 22581784
2019 FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene 87 31324889
2011 BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions. Brain, behavior, and immunity 74 21620951
2007 Evaluation of S100A10, annexin II and B-FABP expression as markers for renal cell carcinoma. Cancer science 74 17083565
2019 FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation. Molecular neurobiology 73 30680690
2017 Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. Science advances 73 28435883
2011 FABP7 expression in normal and stab-injured brain cortex and its role in astrocyte proliferation. Histochemistry and cell biology 73 21938553
1998 Correlation of B-FABP and GFAP expression in malignant glioma. Oncogene 73 9591779
2007 B-FABP-expressing radial glial cells: the malignant glioma cell of origin? Neoplasia (New York, N.Y.) 71 17898869
2012 Neural stem cell specific fluorescent chemical probe binding to FABP7. Proceedings of the National Academy of Sciences of the United States of America 60 22689954
2014 Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 59 25114248
2008 The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells. BMC cancer 59 18826602
1997 Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochimica et biophysica acta 59 9375786
2020 FABP7 upregulation induces a neurotoxic phenotype in astrocytes. Glia 53 32619303
2012 Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA. The Journal of neuroscience : the official journal of the Society for Neuroscience 50 22279223
2009 The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer. Breast cancer research and treatment 49 19590950
2008 Brain fatty acid binding protein (Fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. PloS one 44 18286188
2016 Docosahexaenoic acid up-regulates both PI3K/AKT-dependent FABP7-PPARγ interaction and MKP3 that enhance GFAP in developing rat brain astrocytes. Journal of neurochemistry 41 27787894
2013 Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell and tissue research 40 24114376
2018 Role of FABP7 in tumor cell signaling. Advances in biological regulation 39 30245263
2015 Mapping of brain lipid binding protein (Blbp) in the brain of adult zebrafish, co-expression with aromatase B and links with proliferation. Gene expression patterns : GEP 38 26611722
2003 Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance. Nucleic acids research 37 12771203
2010 Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects. Journal of human genetics 36 20057506
2003 Structure, mRNA expression and linkage mapping of the brain-type fatty acid-binding protein gene (FABP7) from zebrafish (Danio rerio). European journal of biochemistry 36 12581211
2011 Brain lipid binding protein (FABP7) as modulator of astrocyte function. Physiological research 34 21777034
2018 FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 30218856
2023 FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease. GeroScience 30 37688656
2020 FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes. Molecular neurobiology 30 32812201
2022 Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p. Thoracic cancer 23 35355424
2020 The fatty acid binding protein FABP7 is required for optimal oligodendrocyte differentiation during myelination but not during remyelination. Glia 23 32017258
2020 FABP7 is a potential biomarker to predict response to neoadjuvant chemotherapy for breast cancer. Cancer cell international 22 33292226
2018 Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus. Molecular neurobiology 22 29623545
2022 Oleic acid-bound FABP7 drives glioma cell proliferation through regulation of nuclear lipid droplet formation. The FEBS journal 21 36325660
2014 FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast. PloS one 20 25389781
2005 Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. BMC clinical pathology 20 16018821
2022 A Dichotomous Role for FABP7 in Sleep and Alzheimer's Disease Pathogenesis: A Hypothesis. Frontiers in neuroscience 19 35844236
2024 The emerging role of fatty acid binding protein 7 (FABP7) in cancers. Drug discovery today 18 38614160
2021 Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling. Pharmaceutical research 18 33646504
2021 Nuclear FABP7 regulates cell proliferation of wild-type IDH1 glioma through caveolae formation. Molecular oncology 17 34716958
2016 Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina. Investigative ophthalmology & visual science 17 27367508
2021 FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients 16 34444824
2020 Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice. Molecular brain 16 32093736
2018 Expression of radial glial markers (GFAP, BLBP and GS) during telencephalic development in the catshark (Scyliorhinus canicula). Brain structure & function 16 30242506
2013 Neural stem cell isolation from the whole mouse brain using the novel FABP7-binding fluorescent dye, CDr3. Stem cell research 16 24090932
2012 Regulation of the FABP7 gene by PAX6 in malignant glioma cells. Biochemical and biophysical research communications 16 22583899
2010 Identification of FABP7 in fibroblastic reticular cells of mouse lymph nodes. Histochemistry and cell biology 16 21042809
2022 Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation. Cells 15 35269427
2021 The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA. Current research in neurobiology 15 34056625
2013 Probing the interaction of brain fatty acid binding protein (B-FABP) with model membranes. PloS one 13 23555925
2019 Effects of FABP7 on functional recovery after spinal cord injury in adult mice. Journal of neurosurgery. Spine 12 31051461
2023 FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function. Frontiers in systems neuroscience 11 37404868
2021 Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis. Journal of receptor and signal transduction research 11 33472512
2023 Understanding FABP7 binding to fatty acid micelles and membranes. Biophysical journal 10 36698315
2017 Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 10 28844908
2023 Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology 9 37082980
2022 Fatty Acid-Binding Protein 7 (FABP-7), Glutamic Acid and Neurofilament Light Chain (NFL) as Potential Markers of Neurodegenerative Disorders in Psoriatic Patients-A Pilot Study. Journal of clinical medicine 9 35566558
2022 FABP7 inhibits proliferation and invasion abilities of cutaneous squamous cell carcinoma cells via the Notch signaling pathway. Oncology letters 9 35765272
2022 Fabp7 Is Required for Normal Sleep Suppression and Anxiety-Associated Phenotype following Single-Prolonged Stress in Mice. Neuroglia (Basel, Switzerland) 9 36909794
2017 Low-dose DHA-induced astrocyte proliferation can be attenuated by insufficient expression of BLBP in vitro. Prostaglandins & other lipid mediators 9 28917610
2015 Immunohistochemical analysis of sustentacular cells in the adrenal medulla, carotid body and sympathetic ganglion of mice using an antibody against brain-type fatty acid binding protein (B-FABP). Journal of anatomy 9 25753214
2013 Comparative genomic organization and tissue-specific transcription of the duplicated fabp7 and fabp10 genes in teleost fishes. Genome 9 24299108
2024 Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism Organoids. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 39556706
2012 Characterization of the Atlantic salmon (Salmo salar) brain-type fatty acid binding protein (fabp7) genes reveals the fates of teleost fabp7 genes following whole genome duplications. Gene 8 22575613
2023 The HOPX and BLBP landscape and gliogenic regions in developing human brain. Journal of anatomy 7 36794762
2023 Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model. Acta pharmacologica Sinica 7 37605049
2022 Prenatal exposure to inflammation increases anxiety-like behaviors in F1 and F2 generations: possible links to decreased FABP7 in hippocampus. Frontiers in behavioral neuroscience 7 36299292
2009 Backbone and sidechain 1H, 13C and 15N resonance assignments of the human brain-type fatty acid binding protein (FABP7) in its apo form and the holo forms binding to DHA, oleic acid, linoleic acid and elaidic acid. Biomolecular NMR assignments 7 19636954
2008 Expression of brain-type fatty acid-binding protein (fabp7) in medaka during development. Journal of experimental zoology. Part B, Molecular and developmental evolution 7 18561145
2025 FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4+ T-Cell Migration by Regulating M2 Polarization During Liver Fibrosis. Journal of immunology research 6 40017805
2025 Astrocytic FABP7 Alleviates Depression-Like Behaviors of Chronic Unpredictable Mild Stress Mice by Regulating Neuroinflammation and Hippocampal Spinogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 6 40331773
2025 FABP7 is increased in progressive multiple sclerosis and induces a pro-inflammatory phenotype in monocytes through a glycolytic switch. Nature communications 6 40595541
2024 Integrated Transcriptome Profiling and Pan-Cancer Analyses Reveal Oncogenic Networks and Tumor-Immune Modulatory Roles for FABP7 in Brain Cancers. International journal of molecular sciences 6 39596296
2021 Crystal structure of human brain-type fatty acid-binding protein FABP7 complexed with palmitic acid. Acta crystallographica. Section D, Structural biology 6 34196621
2024 Association Between FABP7-5-HT Pattern and Anxiety or Depression in Patients With Psoriasis: A Cross-Sectional Study. Stress and health : journal of the International Society for the Investigation of Stress 5 39498502
2020 Upregulation of FABP7 inhibits acute kidney injury-induced TCMK-1 cell apoptosis via activating the PPAR gamma signalling pathway. Molecular omics 5 33315023
2018 Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain. Journal of chemical neuroanatomy 5 30076883
2025 APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease. Journal of neuroinflammation 4 39885546
2025 FABP7-mediated lipid-laden macrophages drive the formation of pre-metastatic niche and liver metastasis. International journal of biological sciences 4 40765822
2024 Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish. Cell and tissue research 4 39120736
2017 The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure: a nested case-control study. Annals of intensive care 4 28983815
2009 BLBP-immunoreactive cells in the primary culture of neural precursors from embryonic mouse brain. Bulletin of experimental biology and medicine 4 19526148
2024 In Vivo Monitoring of Fabp7 Expression in Transgenic Zebrafish. Cells 3 38994990
2023 A combined computational-biophysical approach to understanding fatty acid binding to FABP7. Biophysical journal 3 36751130
2018 Pax6-dependent regulation of the rat Fabp7 promoter activity. Genes to cells : devoted to molecular & cellular mechanisms 3 29984875
2024 Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the neurovascular unit in the developing mouse hippocampus. Frontiers in cellular neuroscience 2 39484182
2025 FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia. Glia 1 40251832
2025 FABP7 Enhances Endometrial Cancer Cell Migration and Stemness by Activating the Wnt/β-catenin Pathway. Biochemical genetics 1 41402614
2014 Differential expressions of BMPR1α, ACTN4α and FABP7 in Hirschsprung disease. International journal of clinical and experimental pathology 1 24966941
2014 Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7. Chemical biology & drug design 1 25255720
2005 [Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 1 21171323
2026 Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma. Oncogene 0 42014887
2025 Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus). Fish & shellfish immunology 0 41067592
2025 A Neural-Glial Model of the ApoE-SORT1-FABP7 Axis Tied to Sleep Disruption and Alzheimer's Disease Pathophysiology. Biomolecules 0 41154661
2017 [Expression of FABP7 in mouse placenta tissue and human trophoblast HTR-8/Svneo cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 0 28539280