Affinage

FABP5

Fatty acid-binding protein 5 · UniProt Q01469

Length
135 aa
Mass
15.2 kDa
Annotated
2026-04-28
100 papers in source corpus 39 papers cited in narrative 39 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FABP5 is an intracellular fatty acid chaperone that binds long-chain fatty acids—particularly polyunsaturated species such as linoleic, arachidonic, and docosahexaenoic acids—and transports them from the cytosol to the nucleus, where it delivers lipid ligands to activate the nuclear receptors PPARβ/δ and PPARγ, thereby coupling cytosolic lipid metabolism to transcriptional programs controlling differentiation, inflammation, and proliferation (PMID:24692551, PMID:23722546, PMID:31258834). Nuclear translocation of FABP5 is governed by an allosteric mechanism in which polyunsaturated fatty acid binding reorganizes the α-helical cap to expose a nuclear localization signal, a process further regulated by S-glutathionylation of Cys127 and by TRIM45-mediated K33/K63-linked ubiquitination of the NLS domain (PMID:24692551, PMID:34876574, PMID:38755308). Beyond nuclear receptor delivery, FABP5 promotes hydrolysis of the endocannabinoid anandamide to regulate endocannabinoid tone in the brain, nociceptors, and enteroendocrine K cells, with FABP5 deletion elevating anandamide levels and impairing hippocampal learning and pain sensitization (PMID:24644281, PMID:35655086, PMID:25268051). FABP5 also directly binds Raptor to promote mTORC1 assembly in response to ω-6 linoleic acid, interacts with VCP to activate NF-κB–dependent chemokine production in keratinocytes, and channels unsaturated fatty acids into mitochondrial cardiolipin in T cells, linking it to nutrient sensing, innate immune signaling, and immunometabolic regulation (PMID:40080571, PMID:37967009, PMID:34400394).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 1992 High

    The identification and cloning of FABP5 as a novel ~15 kDa fatty acid-binding protein in psoriatic epidermis established a new FABP family member with tissue-specific expression, opening questions about its ligand specificity and physiological role.

    Evidence cDNA cloning, 2D gel electrophoresis, and vaccinia virus heterologous expression from human psoriatic keratinocytes

    PMID:1512466

    Open questions at the time
    • No ligand specificity defined
    • No in vivo function established
  2. 1993 High

    Demonstration that FABP5 binds oleic acid with high affinity but not retinoids distinguished it from retinoid-binding proteins and defined its lipid selectivity as a fatty acid-specific chaperone.

    Evidence Radiobinding assays on epidermal cell extracts

    PMID:8427590

    Open questions at the time
    • Binding affinities for polyunsaturated fatty acids not yet tested
    • No structural basis for selectivity
  3. 2002 High

    Determination of the FABP5 solution structure revealed the canonical β-barrel fold with low backbone dynamics, while FABP5-knockout mice showed impaired skin barrier recovery, linking the structural chaperone to a defined physiological function in epidermal lipid homeostasis.

    Evidence NMR solution structure with 15N relaxation; FABP5-null mice with transepidermal water loss phenotyping

    PMID:12049637 PMID:12479572

    Open questions at the time
    • Mechanism by which FABP5 supports barrier lipid transport unknown
    • No nuclear signaling role yet recognized
  4. 2008 High

    Showing that FABP5 binds a broad spectrum of polyunsaturated fatty acids (DHA, EPA, arachidonic acid) and is required for NGF-induced neurite extension expanded its functional scope beyond skin to neuronal differentiation.

    Evidence Binding assay with multiple PUFAs; antisense knockdown in PC12 cells rescued by recombinant FABP5

    PMID:18513372

    Open questions at the time
    • Downstream transcriptional targets in neurons not identified
    • Nuclear delivery role not yet established
  5. 2010 High

    Knockout studies in keratinocytes revealed that FABP5 channels linoleic acid into 13(S)-HODE production to activate NF-κB signaling and keratin 1 expression, establishing FABP5 as a conduit between fatty acid metabolism and differentiation-specific transcription programs.

    Evidence FABP5-KO keratinocytes with lipid incorporation, NF-κB reporter, and gene expression assays

    PMID:21068754

    Open questions at the time
    • Whether FABP5 delivers oxidized lipids directly to NF-κB pathway components unknown
    • Nuclear receptor involvement not tested in this context
  6. 2013 High

    Genetic ablation of FABP5 in MMTV-ErbB2 mice suppressed mammary tumorigenesis and PPARδ target gene expression, establishing the FABP5→PPARβ/δ nuclear delivery axis as a tumor-promoting signaling mechanism.

    Evidence FABP5-null × MMTV-ErbB2 genetic cross with tumor incidence, growth, and PPARδ gene expression analysis

    PMID:23722546

    Open questions at the time
    • Identity of specific lipid ligands activating PPARδ in this tumor context undefined
    • Role of FABP5 in PPARγ activation not yet resolved
  7. 2014 High

    Crystallographic and mutagenesis studies revealed that polyunsaturated fatty acids induce allosteric communication from the β2 loop to the α-helical cap, exposing a tertiary NLS that licenses nuclear translocation—providing the first structural mechanism for how FABP5 discriminates activating from non-activating fatty acids.

    Evidence X-ray crystallography, NLS mutagenesis, and biochemical translocation assays

    PMID:24692551

    Open questions at the time
    • Dynamic structural intermediates not captured
    • Post-translational regulation of NLS not yet known
  8. 2014 High

    Parallel discoveries that FABP5 promotes anandamide hydrolysis in the brain (regulating PPARβ/δ activation and hippocampal learning) and in GIP-producing K cells (controlling incretin secretion) established FABP5 as a central regulator of endocannabinoid tone across tissues.

    Evidence FABP5-KO mice with endocannabinoid quantification, PPARβ/δ assays, Morris Water Maze; GIP-deficient phenotype in KO mice after oral fat challenge

    PMID:24644281 PMID:25268051

    Open questions at the time
    • Whether FABP5 directly delivers AEA to FAAH for hydrolysis not shown biochemically
    • Tissue-specific regulation of FABP5 in endocannabinoid pathway unclear
  9. 2014 High

    In macrophages, FABP5 was shown to promote lipid droplet formation and IFN-β production, enhancing NK cell recruitment and anti-tumor immunity—revealing a cell type–dependent role where FABP5 is tumor-suppressive in innate immune cells despite being tumor-promoting in cancer cells.

    Evidence E-FABP KO tumor models with lipid droplet imaging, IFN-β assay, and NK cell recruitment analysis

    PMID:24713431

    Open questions at the time
    • How lipid droplet formation couples to IFN-β induction mechanistically unresolved
    • Relative contribution of macrophage vs. tumor-cell FABP5 in vivo not quantified
  10. 2017 High

    Pharmacological and recombinant protein-based inhibition of FABP5 blocked PPARγ activation and suppressed prostate cancer metastasis in orthotopic models, validating the FABP5→PPARγ axis as a druggable node in cancer and extending the nuclear receptor target beyond PPARβ/δ.

    Evidence Competitive inhibitor SBFI26 and recombinant dmrFABP5 in orthotopic prostate cancer xenografts with PPARγ reporter readouts

    PMID:28415688 PMID:31258834

    Open questions at the time
    • Whether FABP5 selectivity for PPARβ/δ vs. PPARγ is tissue- or ligand-determined unresolved
    • No crystal structure of FABP5–PPAR complex
  11. 2019 High

    Epistasis experiments showed that FASN and MAGL require FABP5 co-expression to activate nuclear receptors and drive metastasis, positioning FABP5 as the obligate intracellular shuttle linking de novo and recycled fatty acids to nuclear signaling.

    Evidence siRNA/shRNA knockdown with co-expression rescue, nuclear receptor assays, in vivo metastasis models

    PMID:31831821

    Open questions at the time
    • Direct physical interaction between FABP5 and FASN in this context not shown at the time
    • Specific FA species delivered to nuclear receptors not identified
  12. 2020 High

    Discovery that FABP5 binds HIF-1α and disrupts the FIH–HIF-1α interaction to enhance HIF-1α synthesis in hepatocellular carcinoma demonstrated a non-nuclear-receptor mechanism through which FABP5 integrates lipid and oxygen-sensing pathways.

    Evidence HIF-1α interactome proteomics, co-IP of FABP5–HIF-1α, HIF-1α translation and activity assays under oleic acid treatment

    PMID:33128030

    Open questions at the time
    • Whether fatty acid binding to FABP5 is required for HIF-1α interaction not tested
    • Structural basis of FABP5–HIF-1α complex unknown
  13. 2021 High

    S-glutathionylation of Cys127 was identified as a redox switch that enhances FABP5 fatty acid binding, nuclear translocation, and PPARβ/δ interaction, providing the first post-translational regulatory mechanism for the FABP5 shuttling pathway and linking oxidative stress to anti-inflammatory signaling in macrophages.

    Evidence Quantitative redox proteomics, Cys127 mutagenesis, nuclear fractionation, PPARβ/δ reporter, Grx1 KO mouse validation

    PMID:34876574

    Open questions at the time
    • Whether other redox modifications (S-nitrosylation, sulfenylation) also regulate FABP5 is untested
    • In vivo significance of Cys127 glutathionylation in disease models not established
  14. 2021 High

    Nociceptor-specific FABP5 deletion elevated anandamide, activated CB1-calcineurin signaling, and reduced TRPV1 sensitization, extending the endocannabinoid-regulating function of FABP5 to pain circuits with a defined mechanistic cascade.

    Evidence Conditional KO (TRPV1-Cre), endocannabinoid quantification, CB1 antagonist pharmacology, calcineurin assay, behavioral pain testing

    PMID:35655086

    Open questions at the time
    • Whether FABP5 directly binds AEA to shuttle it to FAAH in nociceptors not biochemically shown
    • Therapeutic window for FABP5 inhibition in pain not defined
  15. 2021 High

    Linoleic acid was found to impair anti-tumor T-cell function through FABP5-mediated mitochondrial transport and cardiolipin incorporation, causing lipid peroxidation; FABP5 depletion rescued T-cell cytotoxicity, revealing FABP5 as a key immunometabolic gatekeeper.

    Evidence FABP5-KO mice, FA uptake assay, mitochondrial ROS and lipid peroxidation measurement, T-cell function assays, in vivo tumor studies

    PMID:34400394

    Open questions at the time
    • How FABP5 directs fatty acids specifically to mitochondrial cardiolipin biosynthesis is unknown
    • Whether this mechanism operates in human tumors not tested
  16. 2022 High

    Myeloid-specific FABP5 deletion studies revealed dual roles: in LPS-stimulated macrophages, FABP5 loss increases oleic acid and activates AMPK to suppress NF-κB, while in alternatively activated macrophages, oleic acid accumulation drives PPARγ-dependent M2 polarization—showing that FABP5 controls the balance of macrophage inflammatory phenotypes through fatty acid redistribution.

    Evidence Myeloid-specific FABP5 KO mice, metabolic FA profiling, RNA-seq, AMPK/NF-κB epistasis experiments, OVA airway inflammation model

    PMID:36384126 PMID:36426981

    Open questions at the time
    • Whether FABP5 differentially channels specific unsaturated FAs to AMPK vs. PPARγ is unclear
    • Structural basis for FA selectivity in macrophage context not defined
  17. 2022 High

    Identification of VCP as a direct FABP5 interactor in keratinocytes, along with the finding that keratinocyte-specific (but not myeloid) FABP5 deletion attenuates psoriatic inflammation and neutrophil recruitment, established a VCP–NF-κB mechanism underlying FABP5's pro-inflammatory role specifically in epithelial cells.

    Evidence FABP5 interactome proteomics, FABP5–VCP co-IP, Krt6a-Cre and LysM-Cre conditional KO mice, NF-κB reporter, neutrophil flow cytometry

    PMID:37967009

    Open questions at the time
    • Whether fatty acid binding is required for VCP interaction unknown
    • Downstream VCP substrates that mediate NF-κB activation not identified
  18. 2023 Medium

    FABP5 was shown to interact with FASN and promote its ubiquitin-proteasome degradation in colorectal cancer, while in pancreatic neuroendocrine neoplasms it regulated FASN stability and activated WNT/β-catenin signaling, indicating context-dependent roles in lipid synthesis enzyme turnover.

    Evidence Co-IP of FABP5–FASN, ubiquitin-proteasome assays, mTOR/autophagy analysis, β-catenin pathway analysis in CRC and PNEN models

    PMID:37302809 PMID:37416772

    Open questions at the time
    • The E3 ligase mediating FABP5-promoted FASN ubiquitination is not identified
    • Opposing roles (FASN degradation vs. lipid droplet promotion) in different cancers are not reconciled mechanistically
    • Single lab for each cancer type
  19. 2024 High

    TRIM45-mediated K33/K63-linked ubiquitination of the FABP5 NLS domain was identified as a second post-translational mechanism (after S-glutathionylation) promoting nuclear translocation and PPARγ interaction, providing direct evidence that non-degradative ubiquitin chains regulate the FABP5 shuttling cycle.

    Evidence IP-tandem mass spectrometry for ubiquitination site mapping, co-IP of TRIM45–FABP5 and FABP5–PPARγ, nuclear fractionation, in vivo HCC rescue experiments

    PMID:38755308

    Open questions at the time
    • Whether TRIM45 and Cys127 glutathionylation act synergistically or independently not tested
    • Deubiquitinase(s) reversing TRIM45 modification unknown
  20. 2025 High

    The discovery that FABP5 directly binds Raptor to enhance mTORC1 assembly and substrate binding in response to ω-6 linoleic acid revealed a new function for FABP5 as a nutrient sensor coupling dietary fatty acids to mTORC1 growth signaling, distinct from its nuclear receptor delivery role.

    Evidence Proteomics, co-IP of FABP5–Raptor, mTORC1 reconstitution and substrate assays, dietary linoleic acid studies in mice

    PMID:40080571

    Open questions at the time
    • Whether FABP5-Raptor binding is regulated by the same NLS/allosteric mechanism as nuclear translocation is unknown
    • Whether this mechanism extends to other ω-6 PUFAs untested
  21. 2025 High

    GPR171 suppresses Th17 differentiation through a cAMP–pCREB axis that represses FABP5 expression; FABP5 blockade rescues colitis in GPR171-deficient mice, placing FABP5 as a pro-inflammatory metabolic effector in adaptive immune T-cell polarization.

    Evidence Gpr171-KO mice with colitis models, RNA-seq, lipidomics, FABP5 inhibitor treatment, Th17 differentiation assays

    PMID:40074327

    Open questions at the time
    • Which FABP5-transported lipid(s) drive Th17 polarization not identified
    • Whether FABP5 acts through PPARs or another mechanism in Th17 cells not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major unresolved questions include: the structural basis for FABP5 interaction with PPARs and Raptor; whether the allosteric NLS mechanism, S-glutathionylation, and TRIM45 ubiquitination converge on a common nuclear entry pathway or are independently regulated; how FABP5 achieves cell-type-specific outcomes (pro-tumor in cancer cells, anti-inflammatory in some macrophage contexts, pro-inflammatory in keratinocytes and Th17 cells); and the identity of the specific lipid species shuttled to each downstream effector.
  • No structure of FABP5 bound to any partner (PPAR, Raptor, VCP, HIF-1α)
  • Cell-type-specific regulatory mechanisms not defined
  • Specific fatty acid ligands for each signaling axis not systematically identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140104 molecular carrier activity 5 GO:0008289 lipid binding 4 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 6 GO:0005829 cytosol 3 GO:0005739 mitochondrion 2 GO:0005811 lipid droplet 2
Pathway
R-HSA-1430728 Metabolism 7 R-HSA-162582 Signal Transduction 7 R-HSA-74160 Gene expression (Transcription) 7 R-HSA-168256 Immune System 5
Partners
FASNHIF1APPARDPPARGRPTORS100A7TRIM45VCP
Complex memberships
mTORC1

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 FABP5 (PA-FABP) was identified as a novel member of the fatty acid-binding protein family, with predicted molecular weight of ~15 kDa and structural similarity (48-56% identity) to known FABPs, confirmed by 2D gel analysis and heterologous expression in vaccinia virus system. cDNA cloning, sequencing, 2D gel electrophoresis, vaccinia virus expression system, polyclonal antibody validation The Journal of investigative dermatology High 1512466
1993 E-FABP (FABP5) in human epidermal cells binds oleic acid with high affinity but does not bind all-trans-, 13-cis-, or 9-cis-retinoic acid nor all-trans-retinol, establishing its lipid-binding specificity. FABP radiobinding analysis directly on protein extracts, PAGE-autoradioblotting Biochemical and biophysical research communications High 8427590
2002 The solution structure of human E-FABP was determined by NMR, revealing a β-barrel composed of 10 anti-parallel β-strands with a uniformly low backbone mobility (average S²=0.88), and the protein structure differs markedly in dynamics from heart-type FABP, implicating a strong interdependence of structure, stability, and ligand-binding affinity. Multi-dimensional NMR, 15N relaxation experiments, hydrogen/deuterium exchange The Biochemical journal High 12049637
2002 FABP5-knockout mice show lower basal transepidermal water loss and impaired recovery of the water permeability barrier after acetone disruption, demonstrating FABP5 is required for normal skin lipid barrier function; H-FABP expression is specifically elevated in liver of KO mice, suggesting functional compensation. FABP5-null mouse phenotyping, transepidermal water loss measurement, Northern blot Molecular and cellular biochemistry High 12479572
1999 E-FABP (FABP5) and S100A7 form a protein complex in the cytosol of human keratinocytes, as demonstrated by co-purification on gel filtration, non-denaturing PAGE, and co-immunoprecipitation from psoriatic scale extracts. Gel filtration, non-denaturing PAGE, co-immunoprecipitation Molecular and cellular biochemistry Medium 10331666
2008 E-FABP (FABP5) binds a broad range of saturated and unsaturated long-chain free fatty acids including DHA, EPA, and arachidonic acid; E-FABP expression in PC12 cells is required for normal neurite extension during NGF-induced differentiation, as antisense knockdown reduces neurite length and exogenous recombinant E-FABP rescues this defect. Binding assay, antisense knockdown, recombinant protein rescue, neurite measurement Journal of neurochemistry High 18513372
2009 FABP5 knockdown in ARPE-19 retinal pigment epithelial cells decreases cholesterol and cholesterol ester levels by ~40%, increases triglycerides by 67%, and reduces apoB100 secretion by 76%, establishing FABP5 as a regulator of lipid metabolism and lipoprotein assembly in RPE cells. siRNA knockdown, lipid analysis, apoB secretion assay Laboratory investigation Medium 19434059
2010 FABP5 regulates keratinocyte differentiation via the linoleic acid derivative 13(S)-HODE-mediated activation of NF-κB signaling: FABP5-KO keratinocytes show reduced linoleic acid incorporation, decreased 13(S)-HODE production, diminished NF-κB activity, and decreased keratin 1 expression. FABP5 knockout mouse keratinocytes, lipid incorporation assay, NF-κB reporter, gene expression analysis The Journal of investigative dermatology High 21068754
2013 FABP5 shuttles ligands from the cytosol to PPARβ/δ in the nucleus to enhance PPARβ/δ transcriptional activity; genetic ablation of FABP5 in MMTV-ErbB2/HER2 mice relieves EGFR downstream effector signaling, decreases PPARδ target gene expression driving cell proliferation, and suppresses mammary tumor development. FABP5-null mouse crossed with MMTV-ErbB2 oncomice, tumor incidence and growth measurement, gene expression analysis, 3T3 ectopic expression oncogenicity assay Cancer research High 23722546
2014 Structural and biochemical analysis showed that activating polyunsaturated fatty acids (linoleic and arachidonic acid) induce allosteric communication between the ligand-sensing β2 loop and a tertiary nuclear localization signal within the α-helical cap of FABP5, permitting nuclear translocation; more saturated, non-activating fatty acids destabilize this activation loop and inhibit NLS formation, revealing that FABP5 is specifically involved in cis-bonded polyunsaturated fatty acid signaling to the nucleus. X-ray crystallography, biochemical binding/translocation assays, NLS mutagenesis The Journal of biological chemistry High 24692551
2014 FABP5 in the brain promotes hydrolysis of anandamide (AEA) into arachidonic acid (reducing endocannabinoid levels) and directly shuttles arachidonic acid to the nucleus where it activates PPARβ/δ; ablation of FABP5 in mice results in excess AEA accumulation, abolished PPARβ/δ activation in the brain, and markedly impaired hippocampus-based learning and memory. FABP5 knockout mice, endocannabinoid measurement, PPARβ/δ activation assay, cognitive behavioral testing (Morris Water Maze, etc.) The Journal of biological chemistry High 24644281
2014 E-FABP (FABP5) in macrophages promotes lipid droplet formation in response to tumor signals and upregulates IFN-β production, thereby suppressing mammary tumor growth; E-FABP-mediated IFN-β signaling further enhances NK cell recruitment to the tumor stroma. E-FABP KO tumor models, lipid droplet imaging, IFN-β assay, NK cell recruitment analysis Cancer research High 24713431
2014 FABP5 is highly expressed in GIP-producing K cells and promotes intracellular transport and inactivation of endocannabinoids including anandamide; FABP5-deficient mice have significantly decreased circulating GIP levels in the fasting state and in response to acute oral fat administration. GFP knock-in mouse, RNA-seq, FABP5 KO mouse, GIP measurement Molecular endocrinology High 25268051
2017 FABP5 overexpression in human fibroblasts (WS1 cells) induces nuclear translocation of SMAD2 and activates the pro-fibrotic TGF-β signaling pathway, and exogenous FABP5-EGFP protein can be incorporated by skin cells and intensify TGF-β signaling. FABP5 overexpression, SMAD2 nuclear fractionation/localization, TGF-β pathway reporter, exogenous protein uptake experiment Radiation research Medium 29215326
2017 The FABP5 inhibitor SBFI26 competitively binds to FABP5 and inhibits cellular fatty acid uptake, thereby blocking FABP5-mediated PPARγ activation and downstream cancer-promoting gene expression, significantly suppressing prostate cancer metastasis and primary tumor growth in orthotopic mouse models. Competitive binding assay, in vitro fatty acid uptake assay, PPARγ reporter, orthotopic xenograft mouse model Oncotarget High 28415688
2018 FABP5 promotes lipolysis of lipid droplets and de novo fatty acid synthesis by upregulating HSL, MAGL, Elovl6, and ACSL1 expression, and activates NF-κB signaling through reactive oxygen species and protein kinase C in aggressive prostate and breast cancer cells. FABP5 knockdown, gene expression analysis (RT-PCR), ROS measurement, PKC/NF-κB pathway analysis Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 29906613
2019 FABP5 acts as an intracellular chaperone delivering fatty acids generated by FASN and MAGL to nuclear receptors; the abilities of FASN and MAGL to promote nuclear receptor activation and PCa metastasis are critically dependent on co-expression of FABP5, positioning FABP5 as a central link between cytosolic lipid metabolism and pro-metastatic nuclear receptor signaling. siRNA/shRNA knockdown, co-expression rescue experiments, nuclear receptor activation assays, in vivo metastasis models Scientific reports High 31831821
2019 FABP5 in castration-resistant prostate cancer cells transports fatty acids to PPARγ in the nucleus, activating PPARγ-dependent downstream genes (including VEGF); the recombinant FABP5 inhibitor dmrFABP5 blocks this pathway, reducing PPARγ phosphorylation and producing 100% reduction in metastatic rate and 13-fold reduction in primary tumor size in orthotopic mouse models. Recombinant inhibitor treatment, PPARγ activation assay, orthotopic xenograft, immunocytochemistry Genes & cancer High 31258834
2019 Palmitate acid promotes nuclear transport of FABP5 in gastric cancer cells, where FABP5 increases nuclear SP1 protein levels, leading to increased UCA1 lncRNA expression and promoting cancer cell metastasis. siRNA knockdown, immunofluorescence for nuclear/cytoplasmic localization, western blot, RT-PCR Cancer cell international Medium 30948930
2020 FABP5 interacts directly with HIF-1α, enhancing HIF-1α synthesis while disrupting FIH/HIF-1α interaction; oleic acid treatment activates the FABP5/HIF-1α axis to promote lipid accumulation and cell proliferation in hepatocellular carcinoma cells. Proteomics/HIF-1α interactome analysis, co-immunoprecipitation, HIF-1α translation/activity assays, fatty acid treatment Communications biology High 33128030
2021 Oxidative stress induces S-glutathionylation of Cys127 in FABP5; this modification promotes FABP5's fatty acid binding ability and nuclear translocation, and promotes its interaction with PPARβ/δ to activate PPARβ/δ target genes and suppress LPS-induced inflammation in macrophages. Grx1-mediated deglutathionylation reverses this modification. Quantitative redox proteomics, site-directed mutagenesis (Cys127), in vitro binding assay, nuclear fractionation, PPARβ/δ reporter, Grx1 KO mouse Nature communications High 34876574
2021 FABP5 deficiency in nociceptors (conditional KO via TRPV1-Cre) augments AEA levels, resulting in CB1-mediated antinociceptive effects; mechanistically, FABP5 deletion suppresses inflammation- and NGF-mediated TRPV1 sensitization via CB1 activation of calcineurin. Conditional (nociceptor-specific) FABP5 knockout, endocannabinoid measurement, CB1 antagonist pharmacology, calcineurin assay, behavioral pain testing Scientific reports High 35655086
2021 LA (linoleic acid) impairs antitumor T-cell responses by inducing E-FABP (FABP5)-mediated mitochondrial transport of LA and its incorporation into cardiolipin, causing mitochondrial ROS production and lipid peroxidation; genetic depletion of E-FABP rescues LA-impaired T-cell responses. Fatty acid uptake assay, mitochondrial ROS measurement, lipid peroxidation assay, FABP5 KO mouse, T-cell function assays, in vivo tumor growth Cancer research High 34400394
2021 FABP5 co-localizes with α-synuclein in mitochondria under oxidative stress (rotenone treatment) in neurons, reducing mitochondrial membrane potential; pharmacological inhibition of FABP5 prevents α-synuclein accumulation in mitochondria and rescues cell death. Co-overexpression, immunofluorescence co-localization, mitochondrial membrane potential measurement, FABP5 inhibitor treatment, cell viability assay Biomedicines Medium 33499263
2022 FABP5 deletion in macrophages increases intracellular unsaturated fatty acids (especially oleic acid), which activates AMPK by increasing AMP/ATP ratio, inhibits NF-κB pathway, and reduces LPS-induced inflammatory responses; this was confirmed by AMPK inhibition rescuing NF-κB signaling in KO macrophages. Myeloid-specific FABP5 KO mice, metabolic analysis (fatty acids, ATP/AMP), RNA-seq, AMPK/NF-κB pathway analysis, chemical/genetic AMPK rescue Journal of immunology High 36426981
2022 FABP5 controls macrophage alternative (M2) activation by selectively regulating long-chain unsaturated fatty acid (especially oleic acid) metabolism; FABP5 deficiency causes oleic acid accumulation, which reprograms metabolism toward enhanced FA β-oxidation, TCA cycle, and oxidative phosphorylation via PPARγ signaling, promoting M2 polarization. Myeloid-specific FABP5 KO mice, OVA-induced airway inflammation model, FA profiling, informatics, PPARγ pathway analysis, in vitro M2 differentiation assay Cell reports High 36384126
2022 FABP5 interacts with valosin-containing protein (VCP), a key NF-κB signaling activator; in keratinocytes, FABP5 promotes NF-κB-dependent chemokine/cytokine production that drives neutrophil chemotaxis in psoriasis; keratinocyte-specific (Krt6a-Cre) but not myeloid-specific (LysM-Cre) FABP5 deletion attenuates psoriatic symptoms and neutrophil recruitment. Global and conditional (Krt6a-Cre, LysM-Cre) FABP5 KO mice, proteomic analysis of FABP5 interactors, VCP co-IP, NF-κB reporter, neutrophil flow cytometry Cell reports High 37967009
2023 FABP5 interacts with FASN and promotes FASN degradation via the ubiquitin proteasome pathway, reducing lipid accumulation and suppressing mTOR signaling to facilitate autophagy in colorectal cancer cells. Co-immunoprecipitation (FABP5-FASN), ubiquitin-proteasome assay, mTOR pathway analysis, autophagy assay, in vivo tumor model International journal of biological sciences Medium 37416772
2023 FABP5 interacts with FASN and regulates FASN expression via the ubiquitin proteasome pathway in pancreatic neuroendocrine neoplasms; FABP5 promotes lipid droplet deposition and activates WNT/β-catenin signaling; carcinogenic effects of FABP5 can be reversed by the FASN inhibitor orlistat. Co-immunoprecipitation, ubiquitin-proteasome assay, lipid droplet staining, β-catenin pathway analysis Cancer science Medium 37302809
2023 NSUN2 stabilizes FABP5 mRNA by inducing m5C methylation, promoting fatty acid metabolism in osteosarcoma cells; knockdown of FABP5 or adding a fatty acid oxidation inhibitor counterbalances the NSUN2-driven OS progression. RNA sequencing, RIP, methylated RIP, FABP5 knockdown, fatty acid oxidation inhibitor treatment Cell death & disease Medium 36792587
2023 FABP5 knockdown in glioma enhances malignancy through canonical NF-κB signaling; FABP5 induces phosphorylation of IKKα, thereby activating NF-κB and promoting EMT. Lentiviral FABP5 knockdown/overexpression, IKKα phosphorylation assay, NF-κB reporter, EMT markers Journal of cellular and molecular medicine Medium 37837625
2023 ALKBH5 increases FABP5 expression in an m6A-IGF2BP2-dependent manner in pancreatic neuroendocrine neoplasms, promoting FABP5-dependent lipid metabolism disorders and activation of PI3K/Akt/mTOR signaling pathway to enhance proliferation. m6A modification assay, IGF2BP2 RIP, FABP5 KD/OE, PI3K/Akt/mTOR pathway analysis Journal of translational medicine Medium 37858219
2024 TRIM45 E3 ligase directly adds K33-type and K63-type poly-ubiquitin chains to the NLS domain of FABP5, promoting FABP5 nuclear translocation; nuclear FABP5 interacts with PPARγ to facilitate downstream lipid synthesis gene expression and HCC progression. IP-tandem mass spectrometry, co-IP, ubiquitination site mapping, nuclear fractionation, PPARγ co-IP, in vitro and in vivo rescue experiments Oncogene High 38755308
2024 Long-chain unsaturated fatty acids released by tumor cells activate PPARγ via FABP5 in tumor-associated macrophages (FABP5-PPARγ signaling), resulting in immunosuppressive properties; macrophage-specific FABP5 deficiency decreases immunosuppressive molecule expression and enhances T cell-dependent anti-tumor immunity. Single-cell RNA sequencing, macrophage-specific FABP5 KO mice, UFA stimulation in vitro, PPARγ activation assay, T-cell cytotoxicity assay Journal of hepatology High 39357545
2024 MELK kinase binds to FABP5 and affects its K48-linked ubiquitination, increasing FABP5 stability and thereby activating the Akt/mTOR signaling axis to weaken RFA-mediated anti-tumor effects in hepatocellular carcinoma. Co-immunoprecipitation (MELK-FABP5), ubiquitination assay (K48R pathway), Akt/mTOR pathway analysis, MELK inhibition/KO experiments Military Medical Research Medium 39871325
2025 FABP5 directly binds to Raptor, the regulatory-associated protein of mTOR, to enhance formation of functional mTORC1 and substrate binding, activated specifically by ω-6 linoleic acid (LA); this defines a nutrient-sensing mechanism by which dietary LA signals through FABP5 to activate mTORC1 and drive proliferation. Proteomics, co-immunoprecipitation (FABP5-Raptor), mTORC1 reconstitution, mTOR substrate assays, FA supplementation experiments, in vivo mouse dietary studies Science High 40080571
2010 FABP5 knockdown during adipocytic induction in 3T3-L1 cells triggers apoptosis via caspase-3 activation and decreases PPARγ and C/EBPα expression; FABP5 maintains preadipocyte viability during differentiation via Akt cascade activation. siRNA knockdown, caspase-3 activity assay, Akt phosphorylation assay, gene expression analysis Molecular biology reports Medium 20238174
2022 FABP5 deficiency in the heart impairs mitochondrial function, increases oxidative stress, reduces mitochondrial respiration in cardiac fibroblasts, and aggravates pathological cardiac remodeling (hypertrophy and fibrosis) after transverse aortic constriction. FABP5 KO mice, TAC model, echocardiography, transmission electron microscopy, ATP detection, siRNA KD in primary cardiac fibroblasts, mitochondrial respiration assay Cardiovascular toxicology Medium 33929718
2025 GPR171 activation suppresses Th17 cell differentiation and intestinal inflammation via the cAMP-pCREB-FABP5 axis; GPR171 deficiency promotes Th17 differentiation by upregulating FABP5 expression, and blocking FABP5 reduces Th17 differentiation in vitro and ameliorates colitis in Gpr171-/- mice. Gpr171 KO mice, colitis models, RNA-seq, lipidomics, FABP5 inhibitor treatment, Th17 differentiation assay Gut High 40074327

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. The Journal of investigative dermatology 225 1512466
2017 Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases. Pharmacology & therapeutics 195 28132904
2020 Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Communications biology 180 33128030
2021 Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages. Nature communications 150 34876574
2020 FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism. Theranostics 140 32550890
2014 Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages. Cancer research 114 24713431
2018 Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids 101 29906613
2014 Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. The Journal of biological chemistry 101 24692551
2013 Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer research 95 23722546
2012 The effects of Fabp7 and Fabp5 on postnatal hippocampal neurogenesis in the mouse. Stem cells (Dayton, Ohio) 92 22581784
1993 Characterization and expression of a novel human fatty acid-binding protein: the epidermal type (E-FABP). Biochemical and biophysical research communications 87 8427590
2010 Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. The Journal of investigative dermatology 84 21068754
2014 Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain. The Journal of biological chemistry 82 24644281
2023 NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation. Cell death & disease 75 36792587
2022 FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism. Cell reports 67 36384126
2019 FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Scientific reports 66 31831821
2022 m6A-induced lncDBET promotes the malignant progression of bladder cancer through FABP5-mediated lipid metabolism. Theranostics 63 36168624
2004 The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer letters 58 15922867
2023 The emerging role of fatty acid binding protein 5 (FABP5) in cancers. Drug discovery today 56 37230284
2019 Lysine Enhances the Stimulation of Fatty Acids on Milk Fat Synthesis via the GPRC6A-PI3K-FABP5 Signaling in Bovine Mammary Epithelial Cells. Journal of agricultural and food chemistry 55 31174423
2015 The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis. The Biochemical journal 54 26614767
2023 FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression. International journal of biological sciences 53 37416772
2020 Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma. Journal for immunotherapy of cancer 53 32611686
2008 Expression of E-FABP in PC12 cells increases neurite extension during differentiation: involvement of n-3 and n-6 fatty acids. Journal of neurochemistry 53 18513372
2024 FABP5+ lipid-loaded macrophages process tumour-derived unsaturated fatty acid signal to suppress T-cell antitumour immunity. Journal of hepatology 52 39357545
2021 CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma. Journal of cellular and molecular medicine 52 34431227
2013 E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro. Experimental dermatology 52 23528210
2002 Analysis on the phenotype of E-FABP-gene knockout mice. Molecular and cellular biochemistry 52 12479572
2019 FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. International journal of oncology 51 30968158
2022 Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma. Cancer gene therapy 46 35902729
2017 Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5. Oncotarget 44 28415688
2000 In situ and immunocytochemical localization of E-FABP mRNA and protein during neuronal migration and differentiation in the rat brain. Brain research 42 10661491
2021 Dietary Fats High in Linoleic Acids Impair Antitumor T-cell Responses by Inducing E-FABP-Mediated Mitochondrial Dysfunction. Cancer research 41 34400394
2013 FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation. American journal of physiology. Lung cellular and molecular physiology 41 23624787
2020 Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer. Cancers 40 31941087
2013 Differential expression and regulatory roles of FABP5 and FABP7 in oligodendrocyte lineage cells. Cell and tissue research 40 24114376
2017 The Role of FABP5 in Radiation-Induced Human Skin Fibrosis. Radiation research 39 29215326
2002 Solution structure and backbone dynamics of human epidermal-type fatty acid-binding protein (E-FABP). The Biochemical journal 39 12049637
2000 PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation. FEBS letters 39 11113456
2017 Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages. Scientific reports 34 28303004
2013 Cigarette smoke decreases airway epithelial FABP5 expression and promotes Pseudomonas aeruginosa infection. PloS one 34 23349676
2008 The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes. The FEBS journal 34 18445037
2024 Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation. International journal of biological sciences 32 38904015
2023 Doxorubicin resistance in breast cancer is mediated via the activation of FABP5/PPARγ and CaMKII signaling pathway. Frontiers in pharmacology 31 37538178
2022 FABP5 Deficiency Impaired Macrophage Inflammation by Regulating AMPK/NF-κB Signaling Pathway. Journal of immunology (Baltimore, Md. : 1950) 31 36426981
1999 Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales. Molecular and cellular biochemistry 31 10331666
2023 ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner. Journal of translational medicine 30 37858219
2021 FABP5 enhances malignancies of lower-grade gliomas via canonical activation of NF-κB signaling. Journal of cellular and molecular medicine 30 33837625
2015 Level of Fatty Acid Binding Protein 5 (FABP5) Is Increased in Sputum of Allergic Asthmatics and Links to Airway Remodeling and Inflammation. PloS one 30 26020772
2006 Characterization of the porcine FABP5 gene and its association with the FAT1 QTL in an Iberian by Landrace cross. Animal genetics 30 17121606
2016 Transcriptome and Metabolome Analyses in Exogenous FABP4- and FABP5-Treated Adipose-Derived Stem Cells. PloS one 29 27936164
2010 SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Molecular biology reports 29 20238174
2006 Metastasis of squamous cell carcinoma of the oral tongue is associated with down-regulation of epidermal fatty acid binding protein (E-FABP). Oral oncology 29 16759896
2023 Role of FABP5 in T Cell Lipid Metabolism and Function in the Tumor Microenvironment. Cancers 28 36765614
2023 FABP5 regulates lipid metabolism to facilitate pancreatic neuroendocrine neoplasms progression via FASN mediated Wnt/β-catenin pathway. Cancer science 28 37302809
2019 Pterostilbene Inhibits Adipocyte Conditioned-Medium-Induced Colorectal Cancer Cell Migration through Targeting FABP5-Related Signaling Pathway. Journal of agricultural and food chemistry 28 31419115
2025 Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. Science (New York, N.Y.) 27 40080571
2021 FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction. Cardiovascular toxicology 27 33929718
2010 Atelocollagen-delivered siRNA targeting the FABP5 gene as an experimental therapy for prostate cancer in mouse xenografts. International journal of oncology 27 19956834
2020 FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples. EBioMedicine 26 32711257
2019 Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ. Genes & cancer 26 31258834
2022 Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF-κB signaling pathway in the retina of aged mice. Aging cell 24 35148456
2021 Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress. Biomedicines 24 33499263
2019 Palmitate acid promotes gastric cancer metastasis via FABP5/SP1/UCA1 pathway. Cancer cell international 24 30948929
2022 FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. Scientific reports 22 35655086
2020 Independent and Distinct Associations of FABP4 and FABP5 With Metabolic Parameters in Type 2 Diabetes Mellitus. Frontiers in endocrinology 22 33071982
2017 Effect of FABP5 gene silencing on the proliferation, apoptosis and invasion of human gastric SGC-7901 cancer cells. Oncology letters 22 29085478
2011 CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells. Experimental dermatology 22 22082219
2009 Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells. Laboratory investigation; a journal of technical methods and pathology 22 19434059
2014 Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice. Journal of molecular histology 21 24879443
2014 RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Molecular endocrinology (Baltimore, Md.) 21 25268051
2021 Downregulation of FABP5 Suppresses the Proliferation and Induces the Apoptosis of Gastric Cancer Cells Through the Hippo Signaling Pathway. DNA and cell biology 20 34160301
2019 DHA and vitamin E antagonized the Aβ25-35-mediated neuron oxidative damage through activation of Nrf2 signaling pathways and regulation of CD36, SRB1 and FABP5 expression in PC12 cells. Food & function 20 30706921
2025 MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies. Military Medical Research 19 39871325
1997 Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid. Acta dermato-venereologica 19 9059669
2024 Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy. The journal of pain 18 38232863
2021 Tumor-intrinsic FABP5 is a novel driver for colon cancer cell growth via the HIF-1 signaling pathway. Cancer genetics 18 34775260
2012 Fatty acid-binding protein 4 (FABP4) and FABP5 modulate cytokine production in the mouse thymic epithelial cells. Histochemistry and cell biology 18 22585040
2023 Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis. Cell reports 17 37967009
2021 FABP5 Is a Sensitive Marker for Lipid-Rich Macrophages in the Luminal Side of Atherosclerotic Lesions. International heart journal 17 33994513
2020 Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis. European review for medical and pharmacological sciences 17 32633377
2015 CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid. Oncotarget 17 25797252
2024 TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation. Oncogene 15 38755308
2023 FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5. Communications biology 15 37438449
2018 4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5. Drug design, development and therapy 14 29731607
2017 Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice. Histochemistry and cell biology 14 28500502
2022 Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor. Behavioural brain research 13 35202717
2022 Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes. Pharmacological research 13 35728766
2021 Serum fatty acid binding protein 5 (FABP5) as a potential biomarker of inflammation in psoriasis. Molecular biology reports 13 34131888
2019 Fatty acid-binding protein 5 (FABP5)-related signal transduction pathway in castration-resistant prostate cancer cells: a potential therapeutic target. Precision clinical medicine 13 35694437
2008 Nucleotide variability and linkage disequilibrium patterns at the porcine FABP5 gene. Animal genetics 13 18565161
2024 Artesunate-binding FABP5 promotes apoptosis in lung cancer cells via the PPARγ-SCD pathway. International immunopharmacology 12 39405934
2023 Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury. Heliyon 12 37636454
2023 FABP5 is important for cognitive function and is an important regulator of the physiological effects and pharmacokinetics of acute Δ9 tetrahydrocannabinol inhalation in mice. Pharmacology, biochemistry, and behavior 12 37716413
2013 Circulating FABP4 and FABP5 levels are differently linked to OSA severity and treatment. Sleep 12 24293757
2025 GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism. Gut 11 40074327
2023 Transcriptome analysis reveals FABP5 as a key player in the development of chicken abdominal fat, regulated by miR-122-5p targeting. BMC genomics 11 37430185
2023 Inhibition of FABP5 attenuates inflammatory bowel disease by modulating macrophage alternative activation. Biochemical pharmacology 11 38081366
2023 Molecular mechanisms on how FABP5 inhibitors promote apoptosis-induction sensitivity of prostate cancer cells. Cell biology international 10 36651331
2023 Aberrant DNA methylation-mediated NF-κB/fatty acid-binding protein 5 (FABP5) feed-forward loop promotes malignancy of colorectal cancer cells. Biochimica et biophysica acta. Molecular and cell biology of lipids 10 37414211