Affinage

FABP4

Fatty acid-binding protein, adipocyte · UniProt P15090

Length
132 aa
Mass
14.7 kDa
Annotated
2026-04-28
100 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FABP4 is an intracellular lipid chaperone and unconventionally secreted adipokine that integrates lipid metabolism, inflammatory signaling, and systemic endocrine communication across adipocytes, macrophages, and endothelial cells. Intracellularly, FABP4 promotes PPARγ ubiquitination and proteasomal degradation to restrain adipogenesis (PMID:24319114), participates in a negative feedback loop with FAT/CD36 to control fat mass expandability (PMID:36674544), and its interaction with hormone-sensitive lipase (HSL) is regulated by PAK4-mediated phosphorylation at T126 to control lipolysis (PMID:38216738). Secreted FABP4 forms the Fabkin hormone complex with adenosine kinase and nucleoside diphosphate kinase to regulate extracellular ATP/ADP levels and pancreatic β-cell insulin secretion, with endothelial cells contributing ~87% of basal circulating FABP4 via an unconventional endosome/secretory lysosome pathway (PMID:34880500, PMID:37279064, PMID:29212659). In macrophages, FABP4 controls NLRP3 inflammasome activation through UCP2-dependent mitochondrial redox regulation (PMID:27795298), drives CXCL1-dependent neutrophil recruitment during bacterial infection (PMID:30462529), and in eosinophils supports integrin-mediated adhesion, migration, and cytoskeletal dynamics (PMID:29696987).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2013 High

    Establishing how FABP4 controls adipogenesis at the molecular level: FABP4 was shown to promote PPARγ ubiquitination and proteasomal degradation, explaining how a fatty acid-binding protein feeds back to limit the master adipogenic transcription factor.

    Evidence FABP4-null preadipocytes/macrophages with elevated PPARγ, complementation rescue, ubiquitination assays

    PMID:24319114

    Open questions at the time
    • E3 ubiquitin ligase mediating FABP4-dependent PPARγ ubiquitination not identified
    • structural basis for FABP4-PPARγ interaction unknown
  2. 2013 High

    Defining transcriptional regulation of FABP4 itself: the FABP4 promoter was shown to integrate signals from both GR (via a negative GRE) and PPARγ (via PPRE), explaining how tamoxifen suppresses macrophage FABP4 and reduces foam cell formation.

    Evidence EMSA, ChIP, promoter-reporter assays, in vivo tamoxifen treatment in ApoE−/− mice

    PMID:23805908

    Open questions at the time
    • Whether other nuclear receptors contribute to FABP4 regulation in non-macrophage lineages not tested
  3. 2017 High

    Revealing how FABP4 links lipid sensing to innate immune activation: FABP4 was found to control the NLRP3 inflammasome via UCP2-dependent mitochondrial redox regulation in macrophages, connecting lipid metabolism to IL-1β production.

    Evidence FABP4 KO and inhibitor-treated macrophages, UCP2 siRNA rescue, caspase-1 cleavage and IL-1β secretion assays

    PMID:27795298

    Open questions at the time
    • Mechanism by which FABP4 regulates UCP2 expression (transcriptional vs. post-transcriptional) not resolved
    • whether specific lipid cargo of FABP4 is required for inflammasome regulation unknown
  4. 2017 High

    Identifying the unconventional secretory route of FABP4: secretion occurs via endosomes and secretory lysosomes, independent of ER-Golgi, GRASP proteins, autophagy, or multivesicular bodies, explaining how a cytosolic protein reaches the circulation.

    Evidence Cell fractionation, live-cell imaging, pharmacological pathway inhibitors, in vivo chloroquine treatment reducing plasma FABP4

    PMID:29212659

    Open questions at the time
    • Signal or motif on FABP4 that targets it to endosomes not identified
    • regulation of secretory lysosome exocytosis of FABP4 not defined
  5. 2018 High

    Establishing cell-autonomous roles in immune cell function beyond macrophages: FABP4 deficiency in eosinophils impaired integrin-mediated adhesion, F-actin polymerization, calcium flux, and migration, revealing a general role in leukocyte cytoskeletal dynamics.

    Evidence FABP4-KO eosinophils, adhesion/migration assays, calcium flux, ERK phosphorylation, allergic airway inflammation model

    PMID:29696987

    Open questions at the time
    • Direct molecular target linking FABP4 to β2-integrin surface expression not identified
    • whether lipid-binding pocket occupancy is required for cytoskeletal effects unknown
  6. 2018 Medium

    Identifying a membrane receptor for extracellular FABP4: cytokeratin 1 (CK1) on endothelial cells was shown by surface plasmon resonance to directly bind FABP4, and CK1 knockdown blocked FABP4-mediated NF-κB and NRF2 activation, establishing a receptor-mediated uptake mechanism.

    Evidence SPR direct binding, CK1 siRNA in HUVECs, NF-κB/NRF2 nuclear translocation assays

    PMID:30521939

    Open questions at the time
    • CK1 as a FABP4 receptor not independently replicated
    • whether CK1 mediates FABP4 signaling in non-endothelial cells untested
    • downstream signaling cascade between CK1 engagement and NF-κB activation not mapped
  7. 2018 High

    Demonstrating a macrophage-specific protective role in innate immunity: FABP4 in macrophages was required for CXCL1 production and neutrophil recruitment during bacterial pneumonia, with bone marrow chimeras establishing macrophages as the protective cell source.

    Evidence FABP4−/− mice, bone marrow chimeras, Pseudomonas aeruginosa pneumonia model, recombinant CXCL1 rescue

    PMID:30462529

    Open questions at the time
    • Molecular mechanism connecting FABP4 to CXCL1 transcription in macrophages not defined
  8. 2021 High

    Discovering the Fabkin hormone complex: FABP4 was found to form a functional extracellular complex with ADK and NDPK that regulates ATP/ADP levels and acts on pancreatic β-cells, transforming understanding of FABP4 from intracellular chaperone to systemic hormone.

    Evidence Co-immunoprecipitation, biochemical reconstitution, extracellular nucleotide measurements, anti-Fabkin antibody in mouse diabetes models

    PMID:34880500

    Open questions at the time
    • Stoichiometry and structural basis of the Fabkin complex not resolved
    • how FABP4 and its partners are co-secreted or assemble extracellularly not determined
  9. 2023 High

    Resolving the cellular source of circulating FABP4: conditional KO mice revealed endothelial cells as the dominant source of basal circulating FABP4 (~87%) while adipocytes contribute the lipolysis-stimulated increase, establishing tissue-specific endocrine roles.

    Evidence Cell-type-specific Fabp4 KO mice (adipocyte, endothelial, myeloid, total), plasma ELISA, lipolysis-stimulated insulin secretion assays

    PMID:37279064

    Open questions at the time
    • Whether endothelial and adipocyte FABP4 differ in Fabkin complex formation not tested
    • signals regulating basal endothelial FABP4 secretion not identified
  10. 2024 High

    Identifying a direct kinase controlling FABP4-HSL interaction: PAK4 phosphorylates FABP4 at T126 and HSL at S565, disrupting their interaction and inhibiting lipolysis; PKA-mediated PAK4 degradation relieves this brake, integrating FABP4 into the catecholamine-lipolysis signaling cascade.

    Evidence In vitro kinase assay, T126/S565 mutagenesis, co-IP, adipose-specific PAK4 overexpression/KO mice, lipolysis assays

    PMID:38216738

    Open questions at the time
    • Whether T126 phosphorylation also affects FABP4 secretion or Fabkin complex formation not examined
    • crystal structure of phospho-T126 FABP4 not available

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how the Fabkin complex assembles and signals at target cells, what lipid cargoes are required for distinct FABP4 functions, and how FABP4 is sorted into secretory lysosomes for unconventional secretion.
  • Structural basis and stoichiometry of Fabkin complex
  • lipid-cargo dependence of individual FABP4 functions
  • sorting signal for FABP4 entry into secretory lysosomes
  • whether CK1-mediated uptake applies to cell types beyond endothelium

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0008289 lipid binding 3 GO:0048018 receptor ligand activity 2
Localization
GO:0005576 extracellular region 4 GO:0005829 cytosol 3 GO:0005764 lysosome 1 GO:0005768 endosome 1
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 3 R-HSA-392499 Metabolism of proteins 2
Partners
ADKATPB (ATP5B)CK1 (KRT1)HSLNDPKPAK4PPARΓUCP2
Complex memberships
Fabkin (FABP4-ADK-NDPK)

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 FABP4 triggers ubiquitination and subsequent proteasomal degradation of PPARγ, thereby attenuating adipogenesis. FABP4-null preadipocytes and macrophages exhibited increased PPARγ expression, and complementation of FABP4 in null macrophages reversed this increase. FABP4-null mouse preadipocytes/macrophages, complementation rescue experiments, ubiquitination assays, Western blot Diabetes High 24319114
2017 FABP4/aP2 regulates macrophage redox signaling and NLRP3 inflammasome activation via control of UCP2 expression. Ablation of FABP4 upregulates UCP2, reduces mitochondrial protein oxidation, attenuates the mitochondrial unfolded-protein response, and ablates IL-1β secretion in response to inflammasome activation. FABP4/aP2-knockout macrophages, FABP4 inhibitor treatment, UCP2 siRNA rescue, caspase-1 cleavage assay, IL-1β secretion assay Molecular and cellular biology High 27795298
2017 FABP4 is secreted via an unconventional pathway involving enclosure within endosomes and secretory lysosomes, independent of the ER-Golgi pathway, GRASP proteins, autophagy, and multivesicular bodies. Chloroquine treatment in mice inhibits this secretion. Cell fractionation, live-cell imaging, pharmacological inhibitors of secretory pathways, chloroquine treatment of mice, Western blot of plasma FABP4 The Journal of cell biology High 29212659
2021 Hormonal FABP4 forms a functional hormone complex called Fabkin with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK), regulating extracellular ATP and ADP levels. This complex acts on pancreatic beta cells and regulates an adipose-beta-cell endocrine axis. Antibody-mediated targeting of this complex improves beta-cell function and prevents diabetes. Co-immunoprecipitation, biochemical reconstitution, extracellular nucleotide measurements, antibody neutralization in mouse models of type 1 and type 2 diabetes, beta-cell functional assays Nature High 34880500
2023 Endothelial cells are the major source of baseline circulating (hormonal) FABP4, contributing ~87% of basal plasma levels, whereas adipocytes are the main source of lipolysis-stimulated FABP4 increases. Endothelial FABP4 is required for lipolysis-driven insulin secretion. Cell-type-specific Fabp4 knockout mice (Adipo-KO, Endo-KO, Myeloid-KO, Total-KO), plasma FABP4 ELISA, lipolysis induction assays, insulin secretion measurements JCI insight High 37279064
2024 PAK4 directly phosphorylates FABP4 at T126 and HSL at S565, impairing the FABP4-HSL interaction and thereby inhibiting lipolysis in adipose tissue. PKA-mediated degradation of PAK4 relieves this inhibition to allow lipolysis. In vitro kinase assay, site-directed mutagenesis (T126 on FABP4, S565 on HSL), co-immunoprecipitation, adipose tissue-specific PAK4 overexpression and knockout mice, lipolysis assays Nature metabolism High 38216738
2019 Exogenous FABP4 interferes with adipocyte differentiation and induces p38/HSL-mediated lipolysis and p38/NF-κB-mediated inflammation in adipocytes in vitro and in vivo. These effects are reversed by FABP4 inhibitor I-9 or p38 MAPK inhibitor SB203580. 3T3-L1 preadipocyte/adipocyte treatment with recombinant FABP4, p38 MAPK inhibitor, FABP4 inhibitor, in vivo mouse injections, Western blot for p38/HSL/NF-κB phosphorylation, RT-qPCR Endocrine Medium 31845180
2016 FABP4 overexpression in cardiomyocytes activates ERK phosphorylation and aggravates pressure overload-induced cardiac hypertrophy; this is inhibited by ERK inhibitor PD098059 or FABP4 inhibitor BMS309403. Heart-specific FABP4 transgenic mice (α-MHC promoter), transverse aortic constriction (TAC), Western blot for p-ERK, hypertrophic marker gene expression, pharmacological inhibition PloS one Medium 27294862
2021 FABP4 in tumor-associated macrophages directly binds ATPB and accelerates its ubiquitination, decreasing intracellular ATP levels, which deactivates the NF-κB/RelA-IL1α pathway and reprograms macrophages to an anti-inflammatory phenotype promoting neuroblastoma progression. Co-immunoprecipitation (FABP4-ATPB interaction), ubiquitination assays, NF-κB pathway analysis, IL1α blocking antibody rescue, in vitro and in vivo tumor growth assays Clinical and translational medicine Medium 33931964
2018 Macrophage FABP4 is required for CXCL1 production, neutrophil recruitment, and bacterial clearance in Pseudomonas aeruginosa pneumonia. Bone marrow chimera experiments confirmed macrophages as the protective source of FABP4; recombinant CXCL1 rescued the FABP4-/- susceptibility phenotype. FABP4-/- mice, bone marrow chimeras, intratracheal P. aeruginosa infection, CXCL1 ELISA, recombinant CXCL1 rescue experiment FASEB journal High 30462529
2018 FABP4 deficiency in eosinophils impairs cell spreading, adhesion to ICAM-1 (via reduced β2-integrin expression), migration, F-actin polymerization, calcium flux, and ERK(1/2) phosphorylation in response to eotaxin-1, reducing eosinophil recruitment and allergic airway inflammation in vivo. FABP4-/- eosinophils, in vitro adhesion/migration assays, F-actin polymerization assay, calcium flux measurement, ERK phosphorylation (Western blot), cockroach antigen mouse model American journal of physiology. Lung cellular and molecular physiology High 29696987
2021 FABP4 activates the JAK2/STAT2 inflammatory pathway in macrophages via Rap1a-induced Tyr416 phosphorylation and membrane translocation of c-Src; SOCS1 provides a negative feedback loop inhibiting JAK2/STAT2 and Rap1a expression. Macrophage cell culture with Hcy stimulation, Western blot for JAK2/STAT2/c-Src phosphorylation, Rap1a knockdown/overexpression, ApoE-/- mouse atherosclerosis model Laboratory investigation Medium 34725437
2018 Extracellular FABP4 is taken up by endothelial cells via cytokeratin 1 (CK1) acting as a membrane receptor; direct FABP4-CK1 binding was confirmed by surface plasmon resonance, and CK1 knockdown blocked eFABP4-mediated pro-inflammatory and pro-oxidative (NF-κB, NRF2) effects in endothelial cells. Surface plasmon resonance (direct protein-protein binding), siRNA knockdown of CK1 in HUVECs, Western blot for NF-κB/NRF2 nuclear translocation, cellular uptake assays Biochimica et biophysica acta. Molecular and cell biology of lipids Medium 30521939
2023 FABP4 in liver sinusoidal endothelial cells (LSECs) promotes CXCL10 expression via NF-κB/p65 signaling, which recruits CXCR3+ macrophages and drives M1 macrophage polarization during NAFLD progression. FABP4 inhibition suppresses this pathway. HFD mouse model, FABP4 inhibitor treatment, flow cytometry for macrophage subtypes, NF-κB inhibitor experiments, recombinant CXCL10 and CXCR3 inhibitor rescue, Western blot for nuclear p65 Biochimica et biophysica acta. Molecular basis of disease Medium 37487374
2013 Tamoxifen inhibits macrophage FABP4 expression through combined effects on the glucocorticoid receptor (GR) activating a negative GRE (nGRE) and inhibiting the PPARγ regulatory element (PPRE) in the Fabp4 promoter, reducing foam cell formation and atherosclerosis. Promoter-reporter assays, EMSA, ChIP, siRNA knockdown of FABP4, primary macrophages from wild-type/ApoE-/- mice, in vivo tamoxifen administration The Biochemical journal High 23805908
2014 Bisphenol A increases FABP4/aP2 expression in 3T3-L1 cells through enhanced transcriptional activity of C/EBPδ and glucocorticoid receptor (GR) at the FABP4 promoter, independently of PPARγ or C/EBPα elevation. 3T3-L1 differentiation assay, RT-qPCR, Western blot, promoter-reporter assay, nuclear receptor pathway analysis Adipocyte Medium 25068083
2022 FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis in rheumatoid arthritis. mTORC1 (regulated by TSC1 and Rheb1 in myeloid cells) controls FABP4 expression in macrophages; inhibiting FABP4 with BMS309403 or reducing its expression via mTORC1 inhibition alleviates RA. Myeloid-specific TSC1-KO and Rheb1-KO mice, BMS309403 pharmacological inhibition, in vitro synoviocyte/angiogenesis assays, in vivo mouse RA models Bone research Medium 35729106
2023 FABP4 exerts a negative feedback loop on FAT/CD36 signaling in adipocytes: fatty acid-mediated FAT/CD36-PPARγ transcriptional activation induces FABP4 accumulation, which in turn reduces FAT/CD36 activity and controls adipocyte size and number (fat mass expandability). Human adipose stem cells, 3T3-L1 and 3T3-MBX cell lines, real-time proliferation/differentiation/lipolysis/lipid uptake assays, FABP4 overexpression/knockdown, FAT/CD36 signaling pathway analysis International journal of molecular sciences Medium 36674544
2021 PXR transcriptionally upregulates FABP4 expression in HepG2 cells in response to valproate, and FABP4 promotes lipid/triglyceride accumulation; knockdown of PXR reduces FABP4 induction and lipid accumulation, while FABP4 overexpression enhances VPA-induced steatosis. PXR siRNA knockdown, PXR overexpression, FABP4 overexpression in HepG2 cells, triglyceride measurement, lipid staining Toxicology letters Medium 33901630

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 Advances in AP2/ERF super-family transcription factors in plant. Critical reviews in biotechnology 398 32522044
2004 Regulation of disease resistance pathways by AP2/ERF transcription factors. Current opinion in plant biology 366 15231271
2013 FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes 269 24319114
2021 Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox biology 226 34030117
2020 Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance. Cancer research 226 32054768
2010 Genomic and transcriptomic analysis of the AP2/ERF superfamily in Vitis vinifera. BMC genomics 201 21171999
2008 Specific DNA-binding by apicomplexan AP2 transcription factors. Proceedings of the National Academy of Sciences of the United States of America 191 18541913
2014 Clathrin adaptors. AP2 controls clathrin polymerization with a membrane-activated switch. Science (New York, N.Y.) 187 25061211
2019 Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. Journal of lipid research 156 30705117
2010 The Apicomplexan AP2 family: integral factors regulating Plasmodium development. Molecular and biochemical parasitology 155 21126543
2014 TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy. EMBO reports 146 24603492
2001 Role of AP2/EREBP transcription factors in gene regulation during abiotic stress. FEBS letters 143 11412854
2006 Molecular evolution of the AP2 subfamily. Gene 128 16388920
2005 Homing into the origin of the AP2 DNA binding domain. Trends in plant science 97 15708341
2022 FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone research 92 35729106
2020 FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Cancer cell international 89 33088219
2020 Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles. Science advances 88 32743075
2001 Petunia Ap2-like genes and their role in flower and seed development. The Plant cell 82 11226182
2017 Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review. European journal of medicinal chemistry 80 28738306
2017 FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2. Molecular and cellular biology 78 27795298
2017 Unconventional secretion of FABP4 by endosomes and secretory lysosomes. The Journal of cell biology 78 29212659
2021 A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature 77 34880500
2012 FABP4 dynamics in obesity: discrepancies in adipose tissue and liver expression regarding circulating plasma levels. PloS one 68 23139800
2004 Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages. Biochemical and biophysical research communications 68 15110783
2017 Expansion and stress responses of the AP2/EREBP superfamily in cotton. BMC genomics 67 28143399
2016 Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4. Oncogene 64 27568980
2022 Molecular Events of Rice AP2/ERF Transcription Factors. International journal of molecular sciences 55 36233316
2020 Transcription factor AP2 controls cnidarian germ cell induction. Science (New York, N.Y.) 55 32054756
2019 High expression of FABP4 and FABP6 in patients with colorectal cancer. World journal of surgical oncology 55 31651326
2024 An AP2/ERF transcription factor confers chilling tolerance in rice. Science advances 54 39196924
2022 Improving bread wheat yield through modulating an unselected AP2/ERF gene. Nature plants 54 35851621
2019 Mutually Regulated AP2/ERF Gene Clusters Modulate Biosynthesis of Specialized Metabolites in Plants. Plant physiology 53 31727678
2019 Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes. Endocrine 52 31845180
2004 Analysis of gymnosperm two-AP2-domain-containing genes. Development genes and evolution 52 14986134
2019 FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism. Cell death & disease 48 31097687
2022 Therapeutic Implications of FABP4 in Cancer: An Emerging Target to Tackle Cancer. Frontiers in pharmacology 47 35899119
2019 Fatty acid binding protein 4 (FABP4) as a potential biomarker reflecting myocardial lipid storage in type 2 diabetes. Metabolism: clinical and experimental 47 30999003
2016 Expansion and stress responses of AP2/EREBP superfamily in Brachypodium distachyon. Scientific reports 47 26869021
2019 AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Developmental cell 45 31353312
2014 Bisphenol A increases aP2 expression in 3T3L1 by enhancing the transcriptional activity of nuclear receptors at the promoter. Adipocyte 45 25068083
2020 AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. EMBO reports 44 32323475
2019 Conformational regulation of AP1 and AP2 clathrin adaptor complexes. Traffic (Copenhagen, Denmark) 43 31313456
2022 Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022. European journal of medicinal chemistry 41 35849941
2014 Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling. Cell reports 41 25310985
2021 High expression of FABP4 in colorectal cancer and its clinical significance. Journal of Zhejiang University. Science. B 40 33615754
2018 The mining and evolutionary investigation of AP2/ERF genes in pear (Pyrus). BMC plant biology 40 29558898
2009 An ARIA-interacting AP2 domain protein is a novel component of ABA signaling. Molecules and cells 40 19390821
2021 FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression. Clinical and translational medicine 38 33931964
2023 Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders. Metabolism: clinical and experimental 37 36842611
2021 FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE-/- mice atherosclerosis. Laboratory investigation; a journal of technical methods and pathology 37 34725437
2016 Origination, Expansion, Evolutionary Trajectory, and Expression Bias of AP2/ERF Superfamily in Brassica napus. Frontiers in plant science 37 27570529
2021 A-FABP in Metabolic Diseases and the Therapeutic Implications: An Update. International journal of molecular sciences 36 34502295
2017 Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. The Journal of endocrinology 36 28385723
2018 Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35 30462529
2018 FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation. American journal of physiology. Lung cellular and molecular physiology 34 29696987
2016 Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PloS one 34 27294862
2014 fabp4 is central to eight obesity associated genes: a functional gene network-based polymorphic study. Journal of theoretical biology 33 25280936
2023 FABP4 Controls Fat Mass Expandability (Adipocyte Size and Number) through Inhibition of CD36/SR-B2 Signalling. International journal of molecular sciences 32 36674544
2016 Transcriptome and Metabolome Analyses in Exogenous FABP4- and FABP5-Treated Adipose-Derived Stem Cells. PloS one 29 27936164
2024 Oleic acid-PPARγ-FABP4 loop fuels cholangiocarcinoma colonization in lymph node metastases microenvironment. Hepatology (Baltimore, Md.) 28 38377465
2023 FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and M1 polarization during NAFLD progression. Biochimica et biophysica acta. Molecular basis of disease 28 37487374
2021 Mechanisms of triggering malaria gametocytogenesis by AP2-G. Parasitology international 28 34119684
2014 Circulating FABP4 is a marker of metabolic and cardiovascular risk in SLE patients. Lupus 27 24390652
2023 Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling. Journal of cellular and molecular medicine 26 37905351
2020 Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease. Current medicinal chemistry 26 30306857
2015 ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis. Journal of cell science 26 25908855
2015 Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Scientific reports 26 26687459
2024 p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL. Nature metabolism 25 38216738
2016 Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia. Schizophrenia research 24 27236410
2020 An AP2/ERF Gene, HuERF1, from Pitaya (Hylocereus undatus) Positively Regulates Salt Tolerance. International journal of molecular sciences 23 32605158
2024 The Effects of FABP4 on Cardiovascular Disease in the Aging Population. Current atherosclerosis reports 22 38698167
2020 Independent and Distinct Associations of FABP4 and FABP5 With Metabolic Parameters in Type 2 Diabetes Mellitus. Frontiers in endocrinology 22 33071982
2014 Transcription factor AP2 epsilon (Tfap2e) regulates neural crest specification in Xenopus. Developmental neurobiology 22 24616412
2023 Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion. JCI insight 21 37279064
2018 Intermittent High Glucose Exacerbates A-FABP Activation and Inflammatory Response through TLR4-JNK Signaling in THP-1 Cells. Journal of immunology research 21 29850615
2018 Variation in the FABP4 gene affects carcass and growth traits in sheep. Meat science 21 30015163
2023 Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment. Phytomedicine : international journal of phytotherapy and phytopharmacology 20 37354697
2017 Biallelic Dicer1 Loss Mediated by aP2-Cre Drives Angiosarcoma. Cancer research 20 28916654
2013 Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways. The Biochemical journal 20 23805908
2009 FABP4: a novel candidate gene for polycystic ovary syndrome. Endocrine 20 19844814
2005 Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene. Gene 20 15890474
2023 AaWIN1, an AP2/ERF protein, positively regulates glandular secretory trichome initiation in Artemisia annua. Plant science : an international journal of experimental plant biology 18 36690278
2023 Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. Acta pharmaceutica Sinica. B 18 37969743
2022 Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice. International journal of molecular sciences 18 35457171
2019 FABP4 in Gestational Diabetes-Association between Mothers and Offspring. Journal of clinical medicine 18 30818771
2019 A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. eLife 18 31464684
2016 Ectopical expression of FABP4 gene can induce bovine muscle-derived stem cells adipogenesis. Biochemical and biophysical research communications 18 27856250
2014 Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration. Traffic (Copenhagen, Denmark) 18 24450359
2023 ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway. Biology direct 17 37957699
2022 miR172 Regulates WUS during Somatic Embryogenesis in Arabidopsis via AP2. Cells 17 35203367
2021 AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptors. Journal of cell science 17 34494650
2018 Extracellular FABP4 uptake by endothelial cells is dependent on cytokeratin 1 expression. Biochimica et biophysica acta. Molecular and cell biology of lipids 16 30521939
2018 FABP4 accelerates glioblastoma cell growth and metastasis through Wnt10b signalling. European review for medical and pharmacological sciences 16 30536325
2024 An AP2/ERF member LlERF012 confers thermotolerance via activation of HSF pathway in lily. Plant, cell & environment 15 39073746
2024 FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca2+ Dynamic Changes. Circulation. Arrhythmia and electrophysiology 15 39212041
2023 Fatty acid-binding protein-4 (FABP4) and matrix metalloproteinase-9 (MMP9) as predictive values for nonalcoholic steatohepatitis (NASH). Lipids in health and disease 15 36609276
2021 GoNe encoding a class VIIIb AP2/ERF is required for both extrafloral and floral nectary development in Gossypium. The Plant journal : for cell and molecular biology 15 33666289
2021 PXR-mediated expression of FABP4 promotes valproate-induced lipid accumulation in HepG2 cells. Toxicology letters 14 33901630
2021 BMP2K phosphorylates AP-2 and regulates clathrin-mediated endocytosis. Traffic (Copenhagen, Denmark) 14 34480404
2019 OsGL6, a conserved AP2 domain protein, promotes leaf trichome initiation in rice. Biochemical and biophysical research communications 14 31767151