Affinage

ETV1

ETS translocation variant 1 · UniProt P50549

Length
477 aa
Mass
55.1 kDa
Annotated
2026-06-09
100 papers in source corpus 53 papers cited in narrative 53 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ETV1 (ER81) is a sequence-specific ETS-family transcription factor that binds GGAA-core DNA elements through its C-terminal ETS domain to activate transcription, functioning across developmental programming and oncogenic gene networks (PMID:7651741, PMID:25866208). Its DNA-binding activity is gated at multiple levels: redox-dependent disulfide dimerization (monomerization raises affinity 40–200-fold) and an intramolecular autoinhibition in which a C-terminal inhibitory helix and an intrinsically disordered N-terminal inhibitory domain perturb the DNA-recognition helix, an autoinhibition relieved by acetylation of N-terminal lysines (PMID:25866208, PMID:28161714). ETV1 is a principal nuclear effector of Ras/MAPK signaling, directly phosphorylated by ERK and by the downstream kinases RSK1, MSK1, MK2 and PKA at serine residues (notably Ser191/Ser216) that tune its transactivation and DNA binding (PMID:8657129, PMID:11551945, PMID:12213813, PMID:12569367). It is acetylated by p300/P/CAF at Lys33 and Lys116 to enhance DNA binding, transactivation, and protein half-life, and engages the coactivators CBP/p300 and p160 family members through its ETS domain (PMID:10982847, PMID:12917345, PMID:14747462); phospho-dependent binding of 14-3-3 proteins (via Ser216) protects ETV1 from degradation and promotes invasion (PMID:23774214). Through these inputs ETV1 directly binds and activates target promoters including MMP-1, hTERT, Her2/neu, Smad7, and Rcl, frequently in HER2/Neu-driven positive feedback loops (PMID:11593430, PMID:14673140, PMID:12112028, PMID:12947087, PMID:18726892). In oncogenesis ETV1 acts as an enhancer-binding master regulator: it specifies interstitial cell of Cajal (ICC) lineage identity and drives GIST, where KIT/PDGFRA-MAPK signaling stabilizes ETV1 protein while ETV1 upregulates KIT in a self-reinforcing circuit (PMID:20927104, PMID:25572173, PMID:25865047); it cooperates with the histone demethylases JMJD2A and JMJD1A to remodel chromatin at YAP1, FOXQ1 and MMP1 in prostate cancer (PMID:26731476, PMID:33174020); and it cooperates with androgen-receptor signaling, while CIC and ERF act as direct transcriptional repressors of the ETV1 gene (PMID:17505060, PMID:23512661, PMID:36383412). In vivo, ETV1 is essential for sensorimotor circuit assembly and proprioceptor differentiation, Pacinian corpuscle formation, cerebellar granule cell and striatal cholinergic interneuron maturation, Schwann-cell remyelination, and cardiac fast-conduction programming, where it regulates Nkx2-5, Gja5, and Scn5a (PMID:10850491, PMID:23522042, PMID:27707970, PMID:21746923, PMID:33849945, PMID:36110998, PMID:27775552, PMID:29967479).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1995 High

    Established ETV1 as a sequence-specific DNA-binding ETS transcription factor and tied it to oncogenic rearrangement, defining its molecular identity.

    Evidence Molecular cloning and DNA-binding assay of the EWS-ETV1 fusion from Ewing's sarcoma; reporter and immunocytochemistry showing nuclear transcriptional activator function

    PMID:7651741 PMID:7700648

    Open questions at the time
    • Endogenous target genes not yet identified
    • Regulatory inputs controlling activity unknown
  2. 1996 High

    Placed ETV1 downstream of Ras/Raf/MEK/ERK signaling, identifying it as a phosphorylation-controlled effector of the MAPK cascade.

    Evidence In vitro ERK-1 kinase assay, dominant-negative Raf/ERK epistasis, reporter and immunolocalization

    PMID:8657129

    Open questions at the time
    • Specific phospho-acceptor sites not mapped
    • Identity of the C-terminal ERK-stimulated kinase undefined
  3. 2000 High

    Demonstrated that ETV1 recruits the CBP/p300 coactivators through its ETS domain, linking its transactivation to chromatin-modifying machinery, and showed it is required in vivo for proprioceptive afferent-motor neuron connectivity.

    Evidence Reciprocal Co-IP, confocal colocalization, domain mapping; Er81 knockout mouse anatomical tracing and behavior

    PMID:10850491 PMID:10982847

    Open questions at the time
    • Direct neuronal target genes not identified
    • Coactivator recruitment mechanism on native promoters not defined
  4. 2001 High

    Identified direct ETV1 target promoters (MMP-1, Her2/neu) and resolved a multi-kinase phosphorylation code (ERK-driven N-terminal sites; MK2 at Ser191/Ser216) that can either enhance or suppress activity.

    Evidence Promoter reporter assays, site-directed mutagenesis of phospho-sites, in vitro kinase assays, co-transfection with HER2/Neu

    PMID:11551945 PMID:11593430 PMID:12112028

    Open questions at the time
    • Cell-type determinants of activating vs inhibitory phosphorylation unclear
    • In vivo relevance of individual sites untested
  5. 2002 High

    Expanded the kinase repertoire (RSK1, PKA) acting on ETV1 and showed phosphorylation at distinct sites can uncouple DNA binding from transactivation.

    Evidence Co-IP, in vitro kinase assays, mutagenesis of Ser191/Ser216/Ser334, reporter assays

    PMID:12213813

    Open questions at the time
    • Structural basis for Ser334-dependent DNA-binding loss unknown
    • Combinatorial effects of multiple kinases not dissected
  6. 2003 High

    Defined acetylation by p300/P/CAF at Lys33/Lys116 as a switch enhancing ETV1 DNA binding, transactivation, and protein stability, and added MSK1/p38 as another activating input.

    Evidence In vitro/in vivo acetylation assays, mutagenesis, pulse-chase stability assays, kinase assays, reporter assays

    PMID:12569367 PMID:12917345 PMID:12947087 PMID:14550555

    Open questions at the time
    • Deacetylases reversing these marks not identified
    • Interplay between phosphorylation and acetylation timing unresolved
  7. 2004 High

    Linked ETV1 to telomerase activation (hTERT) and confirmed p160 coactivators (ACTR/SRC-1/GRIP-1) cooperate with p300 acetyltransferase activity to amplify ETV1 output in HER2/Neu-driven cancer.

    Evidence Promoter mutagenesis, dominant-negative ETV1, telomerase activity assay, Co-IP, acetyltransferase assay

    PMID:14673140 PMID:14747462

    Open questions at the time
    • Whether ETV1 controls hTERT in physiological settings untested
    • Coactivator complex stoichiometry undefined
  8. 2008 High

    Connected ETV1 to androgen-receptor signaling and prostate cancer invasion, and identified Rcl as a direct ChIP-confirmed target supporting tumor growth; also placed ETV1 in Pax6- and Sox-9-dependent transcriptional contexts.

    Evidence ChIP, siRNA knockdown, invasion and xenograft assays; Pax6 promoter mutagenesis and knockout mice; ER81-Sox9 Co-IP/ChIP

    PMID:17505060 PMID:18307776 PMID:18628953 PMID:18726892 PMID:18794142

    Open questions at the time
    • Genome-wide ETV1 occupancy not yet mapped
    • Distinction between truncated and full-length ETV1 mechanisms incomplete
  9. 2010 High

    Established ETV1 as a genome-wide enhancer-binding master regulator of the ICC lineage and GIST, with KIT-MAPK signaling stabilizing ETV1 protein, and extended its oncogenic reach to melanoma via MITF.

    Evidence Genome-wide ChIP-seq, transcriptome profiling, shRNA knockdown, ICC-lineage mouse genetics, protein stability assays; melanocyte transformation and MITF epistasis

    PMID:20160028 PMID:20927104

    Open questions at the time
    • Mechanism of MAPK-dependent protein stabilization not molecularly defined
    • Enhancer co-factors driving ICC identity incompletely cataloged
  10. 2013 High

    Defined opposing roles of ETV1 and ERG in the prostate AR program, established 14-3-3 binding (via Ser216) as a stability and invasion-promoting mechanism, and refined Etv1 dependence of proprioceptor subclasses via muscle NT3.

    Evidence Knock-in mouse models with Pten epistasis, transcriptome profiling; Co-IP/mutagenesis/stability assays; conditional knockout with NT3 rescue; Snail/EMT reporter studies

    PMID:23512661 PMID:23522042 PMID:23774214 PMID:24100634

    Open questions at the time
    • Determinants of ETV1 vs ERG target selectivity unresolved
    • TrkC-Etv1 bypass pathway molecular components incomplete
  11. 2015 High

    Provided structural mechanism for ETV1 DNA recognition and autoregulation (redox dimerization and intramolecular autoinhibition relieved by acetylation), and validated the KIT/PDGFRA-ERK-ETV1 protein-stability feedback circuit as a GIST therapeutic vulnerability.

    Evidence X-ray crystallography, NMR, redox/DNA-binding assays; mouse Kit-activation + Etv1 ablation genetics, combination KIT/MEK inhibition with tumor regression, PDGFRA knockdown

    PMID:25572173 PMID:25865047 PMID:25866208 PMID:28161714

    Open questions at the time
    • In vivo relevance of redox-dependent dimerization unconfirmed
    • E3 ligase mediating ETV1 degradation not identified
  12. 2016 High

    Identified histone-demethylase partnership (JMJD2A) driving prostate carcinoma via chromatin remodeling at YAP1, and established ETV1 as a regulator of cardiac fast-conduction and Pacinian corpuscle programs through specific downstream genes.

    Evidence Co-IP, histone-methylation ChIP, Pten-haplodeficient mouse model; Etv1 knockout cardiac electrophysiology with Nkx2-5/Gja5/Scn5a profiling; Ret/Er81 epistasis and Nrg1 analysis

    PMID:26731476 PMID:27318148 PMID:27707970 PMID:27775552

    Open questions at the time
    • Direct vs indirect regulation of cardiac conduction genes not fully separated
    • How ETV1 directs JMJD2A locus specificity unknown
  13. 2018 High

    Defined ETV1 dose-dependent control of cardiac chromatin and His-Purkinje/atrial gene programs using genome-wide accessibility and active-chromatin profiling plus reciprocal gain/loss-of-function including human iPSC-cardiomyocytes.

    Evidence Cardiomyocyte-specific overexpression/knockout mice, ATAC-seq, H3K27ac ChIP-seq, electrophysiology, iPSC-CM models

    PMID:29930145 PMID:29967479

    Open questions at the time
    • Upstream regulators setting cardiac ETV1 levels unclear
    • Direct enhancer targets within HPS program not all validated
  14. 2019 Medium

    Positioned ETV1 as an FGF-signaling effector antagonizing TGF-β programs, characterized SMAD4 complex formation modulating its activity, and identified PTK2/c-MET as direct metastatic targets in HCC.

    Evidence siRNA/CRISPR abrogation in fibroblasts; ETV1-SMAD4 Co-IP and reporter/invasion assays; ChIP/reporter for PTK2 and c-MET with orthotopic metastasis model

    PMID:31160676 PMID:31461652 PMID:36109787

    Open questions at the time
    • Mechanism of ETV1-SMAD4 functional antagonism vs cooperation context-dependent and unresolved
    • Single-lab Co-IP evidence for SMAD interactions
  15. 2021 High

    Added sumoylation on four lysines as a cofactor-recruitment switch (modulating HDAC1/SMAD4 binding) and established ETV1 control of striatal cholinergic interneuron physiology and habit formation.

    Evidence SUMO modification assay, mutagenesis, Co-IP, reporter/growth assays; cell-type-specific knockout with patch-clamp, in vivo recording and behavior

    PMID:33849945 PMID:34367411

    Open questions at the time
    • SUMO E3 ligases for ETV1 not identified
    • Functional integration of sumoylation with phosphorylation/acetylation undefined
  16. 2022 High

    Identified CIC and ERF as direct co-repressors of the ETV1 gene whose genomic loss drives fusion-independent ETV1 upregulation, and established ETV1 as required for Schwann-cell remyelination via MAG and Runx2.

    Evidence ChIP co-binding at ETV1 regulatory element, shRNA/CRISPR loss-of-function, tumor growth assays; sciatic nerve crush model with ChIP-qPCR/reporter and EM

    PMID:36110998 PMID:36383412

    Open questions at the time
    • Whether CIC/ERF repression operates in non-prostate tissues untested
    • Schwann-cell findings from a single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the layered post-translational code (phosphorylation, acetylation, sumoylation, redox dimerization) is integrated combinatorially to dictate ETV1 locus selection and tissue-specific enhancer occupancy remains unresolved.
  • No unified model linking modification state to genome-wide binding
  • E3 ligase and deacetylase/desumoylase machinery for ETV1 unidentified
  • Mechanism of tissue-specific cofactor choice unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 5 GO:0140110 transcription regulator activity 5
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 4
Partners
CREBBPEP300KDM3AKDM4ARPS6KA1SMAD4SOX9YWHAZ

Evidence

Reading pass · 53 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 ETV1 (ER81) was identified as a fusion partner with EWS in the t(7;22)(p22;q12) translocation in Ewing's sarcoma; the EWS-ETV1 chimeric protein contains the ETS DNA-binding domain of ETV1, which retains sequence-specific DNA-binding activity. Molecular cloning, sequencing, DNA-binding assay Oncogene High 7700648
1995 Human ETV1/ER81 protein localizes to the nucleus (detected by immunocytochemistry in COS-1 cells) and functions as a transcriptional activator at promoters containing ETS binding sites. Transient transfection reporter assay, immunocytochemistry Oncogene Medium 7651741
1996 ER81 (ETV1) is transcriptionally activated by the Ras/Raf/MEK/ERK signaling cascade; activated ERK-1 directly phosphorylates ER81, and the carboxy-terminal region of ER81 is also activated by an ERK-stimulated downstream kinase. Nuclear localization of ER81 is conferred by its DNA-binding domain. Kinase assay (ERK-1 phosphorylation of ER81 in vitro), dominant-negative Raf/ERK constructs, reporter assay, immunolocalization Molecular and cellular biology High 8657129
2000 ER81 (ETV1) co-immunoprecipitates with the transcriptional coactivators CBP and p300, and co-localizes with p300 in nuclear speckles; the ETS DNA-binding domain (aa 249–429) mediates binding to CBP/p300. Two regions within CBP (aa 451–721 and 1891–2175) bind ER81. An ER81-associated kinase phosphorylates ER81 on Ser191 and Ser216, and p300 overexpression enhances this kinase activity. Co-immunoprecipitation, confocal microscopy, in vitro binding, site-directed mutagenesis, reporter assay Molecular and cellular biology High 10982847
2000 Er81 (ETV1) is required in mice for the formation of direct connections between group Ia proprioceptive afferents and motor neurons in the spinal cord; Er81 mutant mice show failure of proprioceptive afferents to form a discrete termination zone in the ventral spinal cord, resulting in severe motor discoordination, despite normal motor neuron specification and muscle spindle induction. Er81 knockout mouse analysis, anatomical tracing, behavioral assay Cell High 10850491
2000 EWS-ETV1 fusion protein suppresses transcription of the TGF-β type II receptor gene; stable expression in NIH-3T3 cells reduces TGF-β RII mRNA, protein, and TGF-β sensitivity, and co-transfection suppresses TGF-β RII promoter activity. Stable transfection, RT-PCR, Western blot, promoter reporter assay Cancer research Medium 10749119
2001 ER81 (ETV1) directly binds to and activates the MMP-1 promoter; HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription via MAP kinase-mediated phosphorylation of ER81 at four N-terminal sites. Blocking phosphorylation at these sites decreases ER81 transcriptional activity. Promoter reporter assay, site-directed mutagenesis, ChIP-like binding assay, co-transfection Oncogene High 11593430
2001 MK2 (MAPKAP kinase 2) phosphorylates ER81 in vitro at Ser191 and Ser216 within its central inhibitory domain, and overexpression of MK2 increases in vivo phosphorylation of ER81 and suppresses ER81-dependent transcription in a cell-type-specific manner. In vitro kinase assay, site-directed mutagenesis, reporter assay, overexpression The Journal of biological chemistry High 11551945
2002 RSK1 binds to ER81, phosphorylates it at Ser191 and Ser216 in vivo, and enhances ER81-dependent transcription downstream of the ERK-MAPK pathway. PKA also phosphorylates ER81 at Ser191/Ser216 and additionally at Ser334; phosphorylation of Ser334 reduces DNA-binding ability but paradoxically enhances transactivation potential. RSK1 also activates the ER81 cofactor CBP. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis, reporter assay The Journal of biological chemistry High 12213813
2002 ER81 activates the Her2/neu promoter through a single ETS binding site; this activation requires ER81 transactivation domains and is enhanced by MAPK stimulation, p300/CBP co-activators, and oncogenic HER2/Neu, forming a positive regulatory feedback loop. Promoter reporter assay, site-directed mutagenesis, co-transfection Journal of cellular biochemistry Medium 12112028
2003 ER81 (ETV1) is acetylated by p300 at Lys33 and Lys116, and by P/CAF at Lys116, in vitro and in vivo. Acetylation enhances ER81 DNA-binding activity, transactivation potential, and in vivo protein half-life. HER2/Neu promotes p300-mediated acetylation of ER81 via the Ras/Raf/MAPK pathway. Acetylation-deficient ER81 mutants show reduced response to HER2/Neu. In vitro acetylation assay, immunoprecipitation, site-directed mutagenesis, reporter assay, pulse-chase (protein stability) Molecular and cellular biology High 12917345
2003 MSK1 directly phosphorylates ER81 at two serine residues and enhances ER81-dependent transcription, particularly via p38-MAPK pathway activation. MSK1 also interacts with CBP/p300 coactivators of ER81 and stimulates CBP transactivation domains, providing an indirect route to ER81 activation. In vitro kinase assay, co-immunoprecipitation, site-directed mutagenesis, reporter assay Oncogene High 12569367
2003 HER2/Neu collaborates with ER81 to activate Smad7 transcription; ER81 binds two ETS sites in the Smad7 promoter, and mutation of one critical site greatly reduces Smad7 induction. HER2/Neu signals to ER81 via ERK-MAPK. TAK1 activates ER81 via p38-MAPK to induce Smad7 promoter activity. Reporter assay, site-directed mutagenesis, co-transfection, Western blot The Journal of biological chemistry Medium 12947087
2003 EWS-ER81 and EWS-Fli-1 fusion proteins activate the MMP-1 promoter; EWS-ER81 binds to c-Jun in vitro and in vivo, and their interaction is potentiated by p300. c-Jun and p300 cooperate with EWS-ER81 to upregulate MMP-1 transcription. Co-immunoprecipitation, reporter assay, in vitro binding FEBS letters Medium 14550555
2004 ER81 (ETV1) activates the hTERT promoter through ER81 binding sites; mutating these sites or suppressing ERK-dependent phosphorylation of ER81 renders the hTERT promoter unresponsive to HER2/Neu. HER2/Neu, Ras, and Raf collaborate with ER81 to increase endogenous hTERT gene transcription and telomerase activity. Promoter reporter assay with site-directed mutagenesis, dominant-negative ER81 expression, endogenous gene expression analysis, telomerase activity assay Molecular and cellular biology High 14673140
2004 ACTR (and related p160 steroid receptor coactivators SRC-1 and GRIP-1) interact with ER81 and augment ER81-mediated transcription. ACTR collaborates with p300 to stimulate ER81 function, and p300's acetyltransferase activity toward ER81 is required for this collaboration. HER2/Neu cooperates with ACTR and p300 to stimulate ER81-mediated transcription. Co-immunoprecipitation, reporter assay, acetyltransferase assay, co-transfection The Journal of biological chemistry Medium 14747462
2007 ETV1 is a novel androgen receptor (AR)-regulated gene; the ETV1 promoter is induced by ligand-activated AR, which recruits AR to the ETV1 promoter in chromatin context. ETV1 in turn regulates endogenous MMP genes and is required for invasion of prostate cancer cells. Reporter assay, ChIP, siRNA knockdown, Matrigel invasion assay, Western blot Molecular endocrinology High 17505060
2008 Full-length ETV1 and N-truncated dETV1 (from fusion transcripts) both induce migration and invasion of prostate epithelial cells, with upregulation of uPA/uPAR and MMPs. Only full-length ETV1 induces anchorage-independent growth and upregulates integrin β3. Full-length ETV1 is a strong transactivator; dETV1 is not. Stable transfection, migration/invasion assays, reporter assay, gene expression profiling Cancer research Medium 18794142
2008 ETV1 (ER81) directly binds to and activates the Rcl (nucleotide metabolism enzyme) promoter in vivo (ChIP confirmed); ETV1 and HER2/Neu cooperate to upregulate the endogenous Rcl gene. ETV1 downregulation suppresses proliferation of HER2/Neu-positive breast cancer cells in vitro and tumor formation in vivo. ChIP, reporter assay, siRNA/shRNA knockdown, in vitro proliferation assay, xenograft model Journal of cellular biochemistry High 18726892
2010 ETV1 is a master regulator of interstitial cells of Cajal (ICC) lineage identity and is required for ICC development; ETV1 is universally highly expressed in GISTs and is required for growth of imatinib-sensitive and resistant GIST cell lines. Activated KIT signaling prolongs ETV1 protein stability (post-translational regulation). Transcriptome profiling and genome-wide ETV1 ChIP-seq show ETV1 acts mainly as an enhancer-binding master regulator of the ICC-GIST transcriptional network. shRNA knockdown, ChIP-seq, transcriptome profiling, ICC-lineage mouse genetics, protein stability assay Nature High 20927104
2010 ETV1 overexpression combined with oncogenic NRAS(G12D) transforms primary melanocytes and promotes tumor formation in mice. ETV1 overexpression elevates MITF expression in immortalized melanocytes, and MITF is necessary for ETV1-dependent oncogenicity. Melanocyte transformation assay, mouse tumor model, siRNA knockdown, Western blot Cancer research Medium 20160028
2011 ETV1 directly binds to the POMC promoter and enhances POMC transcription; Etv1 and Tpit physically interact (Co-IP) and synergize to activate POMC transcription. The ETS-binding site in the POMC promoter is necessary for Etv1 activity in AtT-20 cells. siRNA-mediated knockdown of Etv1 reduces POMC expression. Co-immunoprecipitation, ChIP, reporter assay, siRNA knockdown, Etv1-lacZ knockin mice The Journal of biological chemistry High 21622576
2011 Etv1/Er81 activity-dependently upregulates maturation genes (NR2C, GABAARα6) in cerebellar granule cells; Etv1 is induced by sequential AMPA→NMDA→Nav1.2→Ca2+ channel signaling, then binds Etv1-interacting motifs in maturation gene promoters as shown by ChIP. In vivo knockdown of Etv1 prevents maturation gene upregulation. ChIP, luciferase reporter assay, siRNA knockdown (in vitro and in vivo electroporation), pharmacological inhibition PNAS High 21746923
2012 BDNF signals via TrkB-ERK cascade to phosphorylate Etv1/Er81, and phosphorylated Etv1 binds Ets motifs in the NR2C promoter to activate transcription. Phosphorylation at Ser94 and a cluster of Thr139/Thr143/Ser146 is indispensable for BDNF-mediated NR2C promoter activation. Site-directed mutagenesis, luciferase reporter assay, siRNA knockdown, pharmacological ERK inhibition PNAS High 22586091
2013 ETV1 and ERG control a common transcriptional network but largely in opposing fashion in prostate cancer: ERG negatively regulates androgen receptor (AR) transcriptional program while ETV1 cooperates with AR signaling. ETV1 expression promotes autonomous testosterone production. Only ETV1 (not ERG) supports development of invasive adenocarcinoma under full Pten loss in mice. Targeted knock-in mouse models (Tmprss2-ETV1, Tmprss2-ERG), genetic epistasis with Pten loss, transcriptome profiling, androgen pathway analysis Genes & development High 23512661
2013 All 14-3-3 proteins except 14-3-3σ bind ETV1 in a phosphorylation-dependent manner dictated by Ser216. Non-σ 14-3-3 proteins protect ETV1 from degradation, synergize with ETV1 to activate MMP-1 and MMP-7 transcription, and promote ETV1-dependent migration and invasion. Co-immunoprecipitation, site-directed mutagenesis (S216), reporter assay, shRNA knockdown, Western blot (protein stability) Cancer research High 23774214
2013 Etv1 inactivation in mice reveals proprioceptor subclasses with differential Etv1-dependence for survival and differentiation, linked to levels of NT3 in muscle targets. Elevating muscle-derived NT3 can rescue loss of proprioceptors triggered by Etv1 inactivation, revealing a TrkC-activated Etv1-bypass pathway. Etv1 conditional knockout mice, NT3 overexpression rescue experiment, anatomical analysis Neuron High 23522042
2013 ETV1 transcriptionally upregulates Snail expression to induce epithelial-to-mesenchymal transition in gastric cancer cells; ETV1 overexpression in normal gastric epithelial cells increases invasiveness, and ETV1 knockdown reduces aggressiveness of invasive gastric cancer cells. Overexpression, siRNA knockdown, reporter assay, invasion assay, EMT marker analysis Oncology reports Medium 24100634
2014 The small molecule BRD32048 directly binds ETV1 protein, modulates ETV1-mediated transcriptional activity, inhibits invasion of ETV1-driven cancer cells, and inhibits p300-dependent acetylation of ETV1, thereby promoting ETV1 degradation. Small-molecule microarray screen, direct binding assay, reporter assay, invasion assay, Western blot (protein stability) Molecular cancer therapeutics Medium 24737027
2014 ETV1 directly binds to and cooperates with EWSR1 to transactivate Fgf10 promoter in limb bud mesenchyme; both Etv1 and Ewsr1 bind the conserved AGAAAR cluster in the Fgf10 promoter in vivo and in vitro; Etv1 directly binds the AGAAAR sequence in vitro. Etv1 and Ewsr1 are each necessary for Fgf10 expression and limb bud elongation. ChIP, in vitro DNA-binding assay, reporter assay, siRNA/dominant-negative loss-of-function, chick/mouse limb bud experiments Developmental biology High 25109552
2015 Crystal structures of the ETV1 ETS domain (alone and in complex with DNA) reveal that DNA backbone interactions account for most binding affinity. A coordinated network of water molecules mediates base selection upstream of the GGAA core. ETV1 crystallized as a disulfide-linked dimer; reduction of disulfide bonds (monomerization) increases DNA-binding affinity 40–200-fold, indicating a redox-dependent regulatory mechanism controlling ETV1 activity. X-ray crystallography, biochemical DNA-binding assay, redox manipulation The Journal of biological chemistry High 25866208
2015 MAP kinase activation downstream of KIT stabilizes ETV1 protein; ETV1 in turn positively regulates KIT expression, forming a positive feedback circuit. Combined KIT inhibition (imatinib) and MEK inhibition (MEK162) synergistically destabilize ETV1 and suppress GIST tumor growth, including complete regression in vivo. ETV1 is required for GIST initiation and proliferation in vivo, validated by Etv1 ablation in mouse Kit-activation models. Mouse genetics (Kit activation + Etv1 ablation), protein stability assay, combination drug treatment, in vitro and in vivo tumor growth assay Cancer discovery High 25572173
2015 PDGFRA signaling stabilizes ETV1 protein in GIST cells via ERK-dependent mechanisms; PDGFRA knockdown or inhibition reduces ETV1 protein and expression of KIT, disrupting a KIT-ERK-ETV1-KIT signaling loop. ETV1 knockdown reduces KIT expression and GIST proliferation. siRNA knockdown, pharmacological inhibition (crenolanib), Western blot (protein stability/phosphorylation), cell proliferation assay Gastroenterology Medium 25865047
2015 DNA-binding autoinhibition of ETV1 is mediated by cooperative intramolecular interactions: a C-terminal inhibitory α-helix packs against the ETS domain and perturbs the DNA-recognition helix conformation, while the N-terminal inhibitory domain (NID) is intrinsically disordered but makes transient intramolecular contacts with the DNA-recognition helix via NMR. Acetylation of specific NID lysines activates DNA binding. X-ray crystallography, NMR spectroscopy, acetylation assay, DNA-binding assay Nucleic acids research High 28161714
2016 JMJD2A (KDM4A) histone demethylase binds ETV1 and cooperates with it to drive prostate cancer; ETV1 facilitates JMJD2A recruitment to the YAP1 promoter, leading to changes in histone lysine methylation and increased YAP1 expression. Combined JMJD2A+ETV1 overexpression in Pten-haplodeficient mice causes prostate carcinoma formation. Co-immunoprecipitation, ChIP (histone methylation), mouse transgenic model, shRNA knockdown, reporter assay The Journal of clinical investigation High 26731476
2016 ETV1 is a critical regulator of fast conduction physiology in mouse heart; Etv1 is highly expressed in pectinated atrial myocardium and ventricular conduction system (VCS). Etv1 deficiency causes marked cardiac conduction defects, developmental VCS abnormalities, and loss of normal sodium current heterogeneity. Etv1 regulates expression of Nkx2-5, Gja5, and Scn5a. Etv1 knockout mice, cardiac electrophysiology (ECG, patch clamp), histological analysis, gene expression profiling The Journal of clinical investigation High 27775552
2016 ER81 (ETV1) is functionally required in RET+ mechanosensory neurons for Pacinian corpuscle formation; RET signaling maintains Er81 expression; Er81 null neurons have deficient axon-Schwann cell interactions in corpuscles with reduced Nrg1 isoform expression not required for myelination, placing ER81 in a RET-ER81-NRG1 signaling pathway for Pacinian corpuscle development. Er81 knockout and Ret conditional knockout mice, genetic epistasis, Nrg1 isoform analysis, anatomical/histological analysis The Journal of neuroscience High 27707970
2016 ETV1 activates Sparc and Has2 (hyaluronan synthase 2) as downstream target genes (Sparc confirmed by luciferase assay and in vivo co-localization); ETV1 drives desmoplastic stromal expansion and metastasis in pancreatic cancer, and disruption of Sparc abrogates this phenotype. Luciferase reporter assay, orthotopic xenograft, 3D organoid culture, Etv1 conditional knockout in PDAC mice, immunohistochemistry Gastroenterology Medium 27318148
2017 Hyperglycemia increases ICCs via MAPK1/MAPK3-dependent stabilization of ETV1 protein, which then upregulates KIT expression, causing rapid gastric emptying. This was demonstrated in hyperglycemic mouse models and in isolated ICC lineage cells with pharmacological MAPK manipulation. Mouse models (Leprdb/db, KitK641E/+), ICC cell culture, pharmacological MAPK inhibition, siRNA knockdown, Western blot (ETV1 protein stability), flow cytometry Gastroenterology Medium 28438610
2018 ETV1 overexpression in mouse cardiomyocytes causes atrial dilatation, fibrosis, thrombosis, and arrhythmia. ETV1-deficient mice do not develop atrial remodeling after angiotensin II treatment. ETV1-regulated genes include Ryr2, Jph2, Gja5, Kcnh2, Kcnk3, and Tbx5, identified by chromatin accessibility (ATAC-seq) and active chromatin (H3K27ac ChIP-seq) in isolated atrial cardiomyocytes. Cardiac myocyte-specific ETV1 overexpression and knockout mouse models, ATAC-seq, ChIP-seq (H3K27ac), echocardiography, electrophysiology Circulation research High 29930145
2018 ETV1 promotes a His-Purkinje system (HPS) transcriptional program; cardiomyocyte-specific deletion of ETV1 decreases expression of Nkx2-5, Gja5, and Scn5a and causes HPS hypoplasia and ventricularization of sodium channel properties. Forced ETV1 expression in postnatal ventricular myocytes or human iPSC-derived cardiomyocytes promotes a HPS gene signature and increases inward sodium currents. Cardiomyocyte-specific knockout, viral ETV1 overexpression, human iPSC-cardiomyocyte model, electrophysiology (patch clamp), gene expression profiling Scientific reports High 29967479
2019 ETV1 mediates FGF signaling effects on cancer-associated fibroblast (CAF) gene expression; FGF and TGF-β signaling oppositely modulate CAF effector genes, with ETV1 mediating the FGF effects. Genetic abrogation of ETV1 abolishes FGF-mediated gene regulation and leads to induction of TGF-β-responsive genes. Genetic abrogation (siRNA/CRISPR), pharmacological pathway inhibition, gene expression analysis Cell reports Medium 31461652
2019 ETV1 forms complexes with SMAD4 (Co-IP). SMAD2, SMAD3, and SMAD4 overexpression impairs ETV1's ability to stimulate gene transcription. TGF-β1 inhibits ETV1-induced invasion. Conversely, ETV1 may enhance TGF-β signaling in PC3 cells. Sumoylation-deficient ETV1 shows enhanced interaction with HDAC1 but reduced interaction with SMAD4. Co-immunoprecipitation, reporter assay, invasion assay, Western blot Scientific reports Medium 31160676
2019 ETV1 promotes HCC metastasis by transcriptionally upregulating PTK2 and c-MET (confirmed by luciferase reporter and ChIP). HGF upregulates ETV1 expression through c-MET-ERK1/2-ELK1 pathway, creating a positive feedback loop. Combined PTK2 and c-MET inhibition suppresses ETV1-mediated HCC metastasis. Luciferase reporter assay, ChIP, siRNA knockdown, transwell invasion assay, orthotopic metastatic mouse model Journal of experimental & clinical cancer research Medium 36109787
2020 ETV1 directly binds to JMJD1A (histone demethylase) and cooperates with it (but not a catalytically inactive mutant) to induce the MMP1 gene promoter, similar to ETV1-JMJD2A cooperation. ETV1 and JMJD1A co-regulate FOXQ1 and other ETV1 target genes; both bind the FOXQ1 promoter. FOXQ1 overexpression partially rescues growth inhibitory effects of ETV1 ablation. Co-immunoprecipitation, reporter assay, ChIP, RNA-seq, shRNA knockdown, catalytically inactive mutant International journal of oncology Medium 33174020
2020 ETV1 expression is decreased in the left atrium during cardiac pressure overload (in human heart failure patients and mouse models), contributing to electrical and structural remodeling. ETV1 levels directly correlate with NRG1, ERBB4, SCN5A, and GJA5 expression. Cardiomyocyte-selective Etv1 knockout mice display atrial conduction disease and upregulation of profibrotic programming. Human LA biobank gene expression profiling, two murine pressure overload models (TAC, Ang II), Etv1 cardiomyocyte-selective knockout, RNA-seq Circulation High 33225722
2021 ETV1 can be sumoylated on four different lysine residues by SUMO1. Mutation of sumoylation sites modulates ETV1 transactivation at MMP1 promoter in a cell-type-specific manner. Sumoylation-deficient ETV1 shows enhanced interaction with HDAC1 but no change in complex formation with HDAC3 or JMJD2A, and is less able to bind SMAD4. In LNCaP prostate cancer cells, sumoylation-deficient ETV1 represses cell growth. SUMO modification assay, site-directed mutagenesis, reporter assay, co-immunoprecipitation, cell growth assay International journal of clinical and experimental pathology Medium 34367411
2021 ETV1 regulates cholinergic interneuron (CIN) physiological properties in the striatum; Er81-specific ablation in CINs alters their molecular, morphological, and electrophysiological features, amplifying delayed-rectifier and hyperpolarization-activated currents and disrupting tonic/phasic activity. Er81 loss in CINs impairs pause responses to sensorimotor inputs and disrupts habit formation. Cell-type-specific Cre knockout mice, patch-clamp electrophysiology, in vivo recording in awake mice, behavioral assay The Journal of neuroscience High 33849945
2022 CIC and ERF co-bind the proximal regulatory element of the ETV1 gene and mutually repress ETV1 transcription; concurrent genomic loss of CIC and ERF at chromosome 19q13.2 drives fusion-independent ETV1 upregulation in prostate cancer. Targeting ETV1 in CIC/ERF-deficient prostate cancer limits tumor growth. ChIP, shRNA knockdown, CRISPR-deletion, genomic analysis, tumor growth assay eLife High 36383412
2022 Etv1 promotes Schwann cell proliferation, migration, and differentiation, and is required for remyelination in vivo. Etv1 binds to the promoters of myelination-related genes MAG and Runx2 (confirmed by ChIP-qPCR and luciferase assay) to initiate their transcription. Knockdown of Etv1 in crushed sciatic nerve dramatically abrogates SC remyelination. In vivo sciatic nerve crush model, siRNA knockdown, ChIP-qPCR, luciferase reporter assay, transmission electron microscopy, proliferation/migration assays Annals of translational medicine Medium 36110998
2014 Plakophilin-3 (Pkp3) associates with ETV1 transcription factor and positively modulates ETV1-dependent transcriptional activity; demonstrated by co-immunoprecipitation in Xenopus and mammalian cells. Co-immunoprecipitation, reporter assay, Xenopus embryo experiments PloS one Low 24475179
2008 Pax6 directly activates the Er81 promoter through a conserved upstream DNA sequence containing Pax6 binding sites; one specific Pax6 binding site is necessary and sufficient for full Er81 promoter activation. Er81-positive layer 5 neurons are absent in the rostrolateral cortex of Pax6-null mice. Reporter assay, site-directed mutagenesis of Pax6 binding sites, Pax6 knockout mouse analysis BMC developmental biology Medium 18307776
2008 ER81 and Sox-9 form a complex on the VE-cadherin promoter and are required for retinoic acid-mediated transcriptional regulation of VE-cadherin in breast cancer cells. Co-immunoprecipitation, ChIP, reporter assay, siRNA knockdown PloS one Medium 18628953

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 424 7700648
2000 ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell 406 10850491
2010 ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours. Nature 267 20927104
2012 ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochimica et biophysica acta 222 22425584
2010 Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. British journal of cancer 211 20104229
2013 ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & development 155 23512661
1996 Analysis of the ERK-stimulated ETS transcription factor ER81. Molecular and cellular biology 123 8657129
2007 Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions. The Journal of molecular diagnostics : JMD 122 17690209
2004 Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Molecular and cellular biology 115 14673140
2015 Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer discovery 111 25572173
1994 Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors. Oncogene 109 8152800
2019 Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant. Cell reports 101 31461652
2001 HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene 100 11593430
2017 miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer. BMC cancer 94 29126392
2007 ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Molecular endocrinology (Baltimore, Md.) 93 17505060
2005 Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices. Neuroscience 92 16289830
2003 Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Molecular and cellular biology 92 12917345
2016 Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. The Journal of clinical investigation 91 26731476
2010 An oncogenic role for ETV1 in melanoma. Cancer research 90 20160028
2003 Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene 90 12569367
2013 Etv1 inactivation reveals proprioceptor subclasses that reflect the level of NT3 expression in muscle targets. Neuron 89 23522042
2011 YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. PloS one 85 21559405
2002 Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. The Journal of biological chemistry 85 12213813
2007 Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer. Oncology reports 84 17390040
2000 EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene. Cancer research 84 10749119
2008 Truncated ETV1, fused to novel tissue-specific genes, and full-length ETV1 in prostate cancer. Cancer research 83 18794142
2004 Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. The Journal of biological chemistry 81 14747462
2003 HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. The Journal of biological chemistry 81 12947087
2000 Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Molecular and cellular biology 80 10982847
1995 Molecular characterization of the ets-related human transcription factor ER81. Oncogene 79 7651741
2008 Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer. British journal of cancer 78 18594527
2013 MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours. British journal of cancer 69 23969726
2016 Transcription factor ETV1 is essential for rapid conduction in the heart. The Journal of clinical investigation 66 27775552
2015 Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology 64 25865047
2017 Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying. Gastroenterology 59 28438610
2016 ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer. Gastroenterology 57 27318148
2014 A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Molecular cancer therapeutics 52 24737027
2008 Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. Journal of cellular biochemistry 51 18726892
2014 A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model. PloS one 49 25479232
2019 Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis. Cell death & disease 41 31862871
2002 Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. Journal of cellular biochemistry 41 12112028
2015 Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION. The Journal of biological chemistry 40 25866208
2018 The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia. Circulation research 39 29930145
2022 HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET. Journal of experimental & clinical cancer research : CR 38 36109787
2020 Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling. Circulation 37 33225722
2001 Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. The Journal of biological chemistry 37 11551945
2013 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer research 36 23774214
2011 The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America 36 21746923
2007 ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons. The Journal of comparative neurology 34 17394138
2020 Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling. Cancer management and research 33 32308483
2013 Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer. Neoplasia (New York, N.Y.) 32 23814484
2017 Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic acids research 31 28161714
2016 The utility of ETV1, ETV4 and ETV5 RNA in-situ hybridization in the diagnosis of CIC-DUX sarcomas. Histopathology 31 27790742
2008 Er81 is a downstream target of Pax6 in cortical progenitors. BMC developmental biology 31 18307776
2003 Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter. Brain research. Molecular brain research 29 12750007
2018 ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes. Scientific reports 28 29967479
2008 Analysis of area-specific expression patterns of RORbeta, ER81 and Nurr1 mRNAs in rat neocortex by double in situ hybridization and cortical box method. PloS one 28 18815614
2003 Upregulation of the matrix metalloproteinase-1 gene by the Ewing's sarcoma associated EWS-ER81 and EWS-Fli-1 oncoproteins, c-Jun and p300. FEBS letters 28 14550555
2016 A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles. The Journal of neuroscience : the official journal of the Society for Neuroscience 27 27707970
2015 miR-17 regulates melanoma cell motility by inhibiting the translation of ETV1. Oncotarget 27 26158900
1999 Characterization of the Ets-type protein ER81 in Xenopus embryos. Mechanisms of development 27 10096064
2019 miR-129-5p inhibits prostate cancer proliferation via targeting ETV1. OncoTargets and therapy 26 31190859
2015 Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts. Oncotarget 26 25595908
2014 Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer. Applied immunohistochemistry & molecular morphology : AIMM 26 25203299
2011 Overexpression of full-length ETV1 transcripts in clinical prostate cancer due to gene translocation. PloS one 24 21298110
2013 ETV1 induces epithelial to mesenchymal transition in human gastric cancer cells through the upregulation of Snail expression. Oncology reports 23 24100634
2008 Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells. PloS one 22 18628953
1999 Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human. Oncogene 22 10597226
2019 Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer. Scientific reports 21 31160676
2012 Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America 21 22586091
2020 Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. International journal of oncology 20 33174020
2006 ETS transcription factor ER81 is required for the Pacinian corpuscle development. Developmental dynamics : an official publication of the American Association of Anatomists 20 16493690
2019 Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole-mount radical prostatectomy tissue. The Prostate 18 31584209
2016 Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons. Molecular biology of the cell 18 26941328
2009 Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. Oncology research 18 19718948
2015 ETV1 mRNA is specifically expressed in gastrointestinal stromal tumors. Virchows Archiv : an international journal of pathology 17 26243012
2014 Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PloS one 17 24475179
2021 LncRNA PCGEM1 mediates oxaliplatin resistance in hepatocellular carcinoma via miR-129-5p/ETV1 axis in vitro. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 16 34286514
2012 Rearrangement of the ETS genes ETV-1, ETV-4, ETV-5, and ELK-4 is a clonal event during prostate cancer progression. Human pathology 16 22569213
2002 Expression of the ETS transcription factor ER81 in the developing chick and mouse hindbrain. Developmental dynamics : an official publication of the American Association of Anatomists 16 12412022
2014 Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal. Developmental biology 15 25109552
2021 Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer. International journal of clinical and experimental pathology 14 34367411
2019 A novel PTPRZ1-ETV1 fusion in gliomas. Brain pathology (Zurich, Switzerland) 14 31381204
2017 ETV1-Positive Cells Give Rise to BRAF -Mutant Gastrointestinal Stromal Tumors. Cancer research 14 28539323
2011 The Ets factor Etv1 interacts with Tpit protein for pituitary pro-opiomelanocortin (POMC) gene transcription. The Journal of biological chemistry 14 21622576
2021 Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors. Annals of translational medicine 13 34430591
2014 Altered expression of ETV1 and its contribution to tumorigenic phenotypes in gastrointestinal stromal tumors. Oncology reports 13 24970355
2023 ETV1 inhibition depressed M2 polarization of tumor-associated macrophage and cell process in gastrointestinal stromal tumor via down-regulating PDE3A. Journal of clinical biochemistry and nutrition 12 36936869
2022 The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression. eLife 12 36383412
2002 Ectopic expression of the ets transcription factor ER81 in transgenic mouse mammary gland enhances both urokinase plasminogen activator and stromelysin-1 transcription. Transgenic research 12 12054346
2021 Glucose-Regulated Protein 94 Mediates the Proliferation and Metastasis through the Regulation of ETV1 and MAPK Pathway in Colorectal Cancer. International journal of medical sciences 11 33967600
2019 Identification of phenothiazine as an ETV1‑targeting agent in gastrointestinal stromal tumors using the Connectivity Map. International journal of oncology 11 31268158
2014 MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases. Archives of dermatological research 11 25073704
2013 Comprehensive Analysis of ETS Family Members in Melanoma by Fluorescence In Situ Hybridization Reveals Recurrent ETV1 Amplification. Translational oncology 11 23908683
2011 ER81 Expression in Breast Cancers and Hyperplasia. Pathology research international 11 21559090
2022 The Etv1/Er81 transcription factor coordinates myelination-related genes to regulate Schwann cell differentiation and myelination. Annals of translational medicine 10 36110998
2021 Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation. The Journal of neuroscience : the official journal of the Society for Neuroscience 10 33849945
2016 The Etv1 transcription factor activity-dependently downregulates a set of genes controlling cell growth and differentiation in maturing cerebellar granule cells. Biochemical and biophysical research communications 10 27059140
2012 Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China. Asian Pacific journal of cancer prevention : APJCP 10 23244085
2019 Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression. Journal of cellular biochemistry 9 30629294

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