- Length
- 225 aa
- Mass
- 24.8 kDa
- Annotated
- 2026-06-13
31 papers in source corpus
12 papers cited in narrative
11 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
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Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 11 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2019 | TIP30 (tumor suppressor) binds eEF1A and prevents its interaction with eEF1B2, thereby inhibiting translational elongation and suppressing cardiac hypertrophy. This was established by showing TIP30 co-immunoprecipitates with eEF1A, and that TIP30 overexpression reduces eEF1A–eEF1B2 complex formation. | Co-immunoprecipitation, cardiac-specific overexpression and knockout mouse models, pharmacological inhibition of protein synthesis | EMBO molecular medicine | Medium | 31468715 |
| 2016 | EEF1B2 (eukaryotic elongation factor 1-beta) physically interacts with nucleotides 81–100 of the 5′ UTR of the Nipah virus M gene mRNA and specifically enhances translation of the M protein, promoting viral budding. | RNA pull-down assay, reporter translation assay | Archives of virology | Medium | 27236461 |
| 2001 | The human EEF1B2 gene maps to chromosome 2q33, spans six exons (intron-containing locus), and encodes translation elongation factor 1Bα. A previously described locus EEF1B1 on chromosome 15 is actually a processed pseudogene corresponding to an alternative splice form of EEF1B2, not a separate structural gene. | Comparative genomic mapping, exon–intron structure determination, expression analysis across tissues | Genomics | High | 11597139 |
| 2018 | EEF1B2 (eEF1Bα) is the guanine nucleotide exchange factor subunit for eEF1A within the multi-subunit eEF1 complex; loss-of-function mutations in EEF1B2 cause autosomal-recessive intellectual disability, consistent with its essential housekeeping role in GTP exchange during translation elongation. | Human genetics (homozygous LoF variant identification in affected siblings), literature synthesis of eEF1 complex biochemistry | Human mutation | Medium | 30370994 31845318 |
| 2022 | Biallelic (compound heterozygous) pathogenic variants in EEF1B2 nearly abolish EEF1B2 mRNA and protein in patients with intellectual disability and fever-sensitive seizures. Knockout of eef1b2 in zebrafish (crispants) produced abnormal development and light-induced hyperactivity, establishing a direct causal link between EEF1B2 loss of function and neurodevelopmental pathology. | QPCR, Western blot (patient cells), CRISPR F0 zebrafish knockout with behavioral and developmental phenotyping | Human mutation | Medium | 35015920 |
| 2024 | EEF1B2 regulates the osteogenesis–adipogenesis balance in bone marrow-derived mesenchymal stem cells (BMSCs) via Wnt/β-catenin signaling: EEF1B2 suppression reduces β-catenin activity, inhibits osteogenic differentiation, and promotes adipogenesis, while EEF1B2 overexpression in mouse tibias reduces bone loss and marrow adiposity in an osteoporosis model. | siRNA knockdown and overexpression in BMSCs, in vivo adeno-associated virus delivery to mouse tibia, Western blot for β-catenin pathway components, histology | Cellular and molecular life sciences : CMLS | Medium | 38878096 |
| 2024 | EEF1B2 knockdown in human spermatogonial stem cell (SSC) lines impairs proliferation and viability, reduces self-renewal proteins PLZF and CCNE1, and decreases TAF4B expression; restoration of TAF4B rescues the proliferation defect, placing EEF1B2 upstream of TAF4B in the regulation of SSC self-renewal. | siRNA knockdown, RNA sequencing, CCK8/EdU proliferation assays, Western blot, rescue experiment with TAF4B | Heliyon | Medium | 39281470 |
| 2026 | Cannabidiol (CBD) binds the guanine nucleotide exchange factor domain of EEF1B2, inhibiting its translational elongation function and thereby reducing C/EBPβ protein synthesis, which suppresses the differentiation and generation of myeloid-derived suppressor cells (MDSCs) in colorectal adenomas. | Target responsive accessibility profiling (to identify CBD binding), single-cell RNA sequencing, multiple immunology and molecular biology assays in mouse adenoma models | Journal for immunotherapy of cancer | Medium | 41485775 |
| 2026 | EEF1B2 physically interacts with the AAA+ ATPase domain of KATNA1 (katanin A1), potentiates KATNA1-dependent microtubule severing in COS7 cells, and promotes KATNA1-dependent neurite outgrowth and branching in primary cortical neurons; EEF1B2 knockdown attenuates KATNA1-driven microtubule loss. | Proteomic screening, GST pull-down, co-immunoprecipitation, KATNA1-dependent microtubule severing assay in COS7 cells, neurite outgrowth assay in primary cortical neurons with siRNA knockdown | Neuroscience | Medium | 42002067 |
| 2021 | Proteogenomic analysis identified three novel protein isoforms of EEF1B2 via novel junction peptides detected by mass spectrometry, indicating that alternative pre-mRNA splicing generates EEF1B2 protein variants with significant N-terminal sequence differences from the canonical product. | Novel junction peptide identification strategy (CJunction), mass spectrometry of HeLa cell proteome (PXD004452), proteogenomics validation | Journal of proteome research | Medium | 34420305 |
| 2009 | EEF1B2 protein levels are specifically down-regulated during cellular senescence (induced by ionizing radiation, hydrogen peroxide, or anticancer drugs) but not during apoptosis or transient cell-cycle arrest; siRNA-mediated knockdown of eEF1B2 impairs cell proliferation, establishing a functional role in sustaining proliferation. | Comparative proteomics, Western blot, siRNA knockdown with proliferation readout, across multiple cancer cell lines and xenograft models | Cancer research | Medium | 19487283 |
Source papers
Stage 0 corpus · 31 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2009 | Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. | Cancer research | 75 | 19487283 |
| 2012 | A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. | PloS one | 71 | 22860045 |
| 2018 | The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders. | Human mutation | 57 | 30370994 |
| 2018 | Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort. | Epigenetics | 39 | 30001177 |
| 2021 | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases. | Genes & diseases | 33 | 35685457 |
| 2021 | Identification of potential biomarkers for pathogenesis of Alzheimer's disease. | Hereditas | 25 | 34225819 |
| 2019 | TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. | EMBO molecular medicine | 25 | 31468715 |
| 2021 | Deciphering the complexity of sperm transcriptome reveals genes governing functional membrane and acrosome integrities potentially influence fertility. | Cell and tissue research | 22 | 33783607 |
| 2020 | LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway. | Aging | 22 | 32628130 |
| 2014 | Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation. | Oncology reports | 21 | 24626611 |
| 2022 | Identifying patterns of immune related cells and genes in the peripheral blood of acute myocardial infarction patients using a small cohort. | Journal of translational medicine | 20 | 35864510 |
| 2016 | Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes. | Scientific reports | 19 | 27225414 |
| 2019 | Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation. | Life sciences | 17 | 31639400 |
| 2021 | Transcriptome analysis provides insights into copper toxicology in piebald naked carp (Gymnocypris eckloni). | BMC genomics | 12 | 34090338 |
| 2001 | Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event. | Genomics | 11 | 11597139 |
| 2022 | Novel biallelic loss of EEF1B2 function links to autosomal recessive intellectual disability. | Human mutation | 10 | 35015920 |
| 2020 | New evidence that biallelic loss of function in EEF1B2 gene leads to intellectual disability. | Clinical genetics | 9 | 31845318 |
| 2020 | Data article on genes that share similar expression patterns with EEF1 complex proteins in hepatocellular carcinoma. | Data in brief | 9 | 32025546 |
| 2024 | EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling. | Cellular and molecular life sciences : CMLS | 7 | 38878096 |
| 2023 | Stem cells from human exfoliated deciduous teeth rejuvenate the liver in naturally aged mice by improving ribosomal and mitochondrial proteins. | Cytotherapy | 6 | 37815776 |
| 2021 | Proteogenomics Integrating Novel Junction Peptide Identification Strategy Discovers Three Novel Protein Isoforms of Human NHSL1 and EEF1B2. | Journal of proteome research | 6 | 34420305 |
| 2024 | Computational Modeling to Identify Drugs Targeting Metastatic Castration-Resistant Prostate Cancer Characterized by Heightened Glycolysis. | Pharmaceuticals (Basel, Switzerland) | 5 | 38794139 |
| 2016 | Eukaryotic elongation factor 1-beta interacts with the 5' untranslated region of the M gene of Nipah virus to promote mRNA translation. | Archives of virology | 5 | 27236461 |
| 2024 | Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach. | Cancers | 4 | 38730619 |
| 2022 | Identification and Validation of Novel Potential Pathogenesis and Biomarkers to Predict the Neurological Outcome after Cardiac Arrest. | Brain sciences | 3 | 35884735 |
| 2025 | Exploration of RNA-binding proteins identified RPS27 as a potential regulator associated with Kaposi's sarcoma development. | BMC cancer | 2 | 40016701 |
| 2020 | [Effect of NUDT21 on Alternative Splicing of Transcripts in K562 Cells]. | Zhongguo shi yan xue ye xue za zhi | 2 | 33067945 |
| 2015 | Topological centrality-based identification of hub genes and pathways associated with acute viral respiratory infection in infants. | Genetics and molecular research : GMR | 2 | 26782481 |
| 2024 | EEF1B2 regulates the proliferation and apoptosis of human spermatogonial stem cell lines through TAF4B. | Heliyon | 1 | 39281470 |
| 2026 | Cannabidiol suppresses emergency MDSCs generation by disturbing EEF1B2-mediated C/EBPβ protein synthesis in colorectal adenomas. | Journal for immunotherapy of cancer | 0 | 41485775 |
| 2026 | EEF1B2 interacts with KATNA1 to potentiate microtubule severing and neurite outgrowth. | Neuroscience | 0 | 42002067 |
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