Affinage

DONSON

Protein downstream neighbor of Son · UniProt Q9NYP3

Length
566 aa
Mass
62.7 kDa
Annotated
2026-04-28
100 papers in source corpus 10 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DONSON is a vertebrate-specific replication initiation and fork protection factor essential for CDC45-MCM-GINS (CMG) helicase assembly during S-phase. It scaffolds a pre-loading complex containing GINS, TOPBP1, and DNA polymerase ε, and as a dimer bridging two CMG helicases, delivers GINS to MCM2-7 in a CDK- and DDK-dependent manner; its chromatin association requires the pre-replicative complex, and it binds the CMG transiently during S-phase but is dispensable for MCM2-7 loading in G1 (PMID:37590370, PMID:37820732, PMID:37458194, PMID:37781960). Loss of DONSON causes nucleolytic cleavage of stalled replication forks, impairs ATR-dependent checkpoint signaling, and produces chromosomal instability, while DONSON-bound replisomes are enriched at euchromatic regions in early S-phase (PMID:28191891, PMID:32769987). Biallelic DONSON mutations cause microcephalic dwarfism, and patient-derived mutations that disrupt DONSON dimerization or nuclear localization compromise CMG assembly and DNA replication (PMID:28191891, PMID:37820732, PMID:31784481).

Mechanistic history

Synthesis pass · year-by-year structured walk · 5 steps
  1. 2000 Low

    Before any function was known, the DONSON gene was identified as a conserved locus immediately downstream of SON on chromosome 21, establishing it as a broadly expressed gene of unknown function.

    Evidence Genomic sequencing, EST database analysis, and Northern blot/RT-PCR in mouse and human

    PMID:10950926

    Open questions at the time
    • No functional data; expression pattern alone does not indicate mechanism
    • Relationship to DNA replication not yet suspected
  2. 2017 High

    DONSON was established as a replisome component and fork protection factor: its deficiency caused nucleolytic cleavage of stalled forks, impaired ATR checkpoint signaling, and produced chromosomal instability, explaining why biallelic mutations cause microcephalic dwarfism.

    Evidence Patient-derived cell lines with biallelic mutations, fork stability assays, ATR signaling analysis, replisome fractionation across 29 patients; mouse knockout lethality and embryonic brain expression confirmed essential developmental role

    PMID:28191891 PMID:28630177

    Open questions at the time
    • Precise molecular contacts within the replisome not defined
    • Whether DONSON acts at initiation versus elongation not resolved
    • Mechanism of ATR signaling impairment unclear
  3. 2019 Medium

    Patient missense variants revealed that nuclear localization is required for DONSON function, linking mislocalization to replication failure in Meier-Gorlin syndrome.

    Evidence Linked-read WGS of Meier-Gorlin syndrome patients with nuclear localization assays for missense variants

    PMID:31784481

    Open questions at the time
    • No reconstitution of replication function upon restoration of nuclear localization
    • Structural basis for nuclear import not determined
  4. 2020 High

    Genome-wide mapping showed that DONSON-bound replisomes are enriched at euchromatin in early S-phase, distinguishing them from FANCM-bound replisomes in late S-phase heterochromatin, thus revealing temporal and spatial specialization of replisome subtypes.

    Evidence ChIP-seq and iPOND in stressed and unstressed human cells with S-phase fractionation

    PMID:32769987

    Open questions at the time
    • Whether DONSON itself determines early-firing origin selection or passively reflects it
    • Functional consequence of DONSON/FANCM partition not tested by depletion
  5. 2023 High

    A suite of structural, biochemical, and genetic studies converged to define DONSON's molecular mechanism: it scaffolds a pre-loading complex (GINS, TOPBP1, DNA pol ε) via N-terminal PGY and NPF motifs, dimerizes to bridge two CMG helicases, and delivers GINS to MCM2-7 in a CDK- and DDK-dependent manner, with cryo-EM revealing how DONSON reconfigures MCM motors in a double-CMG complex.

    Evidence Cryo-EM of double CMG from Xenopus extracts; AlphaFold-guided interaction mapping validated by Co-IP and in vitro reconstitution; auxin-inducible degron depletion in mouse ES cells; Xenopus immunodepletion with CDK/DDK inhibition; patient mutation modeling in mouse

    PMID:37458194 PMID:37590370 PMID:37638758 PMID:37781960 PMID:37820732

    Open questions at the time
    • Atomic-resolution structure of human DONSON in complex with the full CMG is lacking
    • How DONSON is removed after CMG assembly to allow elongation is unresolved
    • Whether DONSON has a direct role during elongation beyond its transient S-phase association remains debated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include how DONSON dissociates from the CMG after helicase activation, what structural features specify its enrichment at early-firing euchromatic origins, and whether its fork protection role is mechanistically separable from its initiation function.
  • No reconstitution of DONSON release from active CMG
  • No separation-of-function mutant distinguishing initiation from fork protection roles
  • No high-resolution structure of full human DONSON-CMG complex

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005694 chromosome 4 GO:0005634 nucleus 2
Pathway
R-HSA-69306 DNA Replication 6 R-HSA-1640170 Cell Cycle 2 R-HSA-73894 DNA Repair 1
Partners
CDC45FANCMGINSMCM2POLETOPBP1
Complex memberships
double CMG complexpre-loading complex (pre-LC)

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 DONSON is a replisome component that stabilizes replication forks during genome replication. Loss of DONSON leads to nucleolytic cleavage of stalled replication forks and severe replication-associated DNA damage. ATR-dependent signaling in response to replication stress is impaired in DONSON-deficient cells, resulting in decreased checkpoint activity and chromosomal instability. Patient-derived cell lines with biallelic mutations, replication fork stability assays, DNA damage quantification, ATR checkpoint signaling assays, replisome fractionation Nature genetics High 28191891
2023 DONSON scaffolds a vertebrate pre-loading complex (pre-LC) containing GINS, TOPBP1, and DNA polymerase ε, and docks this pre-LC onto MCM2-7 to deliver GINS to its binding site during CMG helicase assembly. A patient-derived DONSON mutation compromises CMG assembly and recapitulates microcephalic dwarfism in mice. AlphaFold-based protein-protein interaction screening followed by experimental validation, Co-IP, in vitro reconstitution, mouse model with patient-derived mutation Science High 37590370
2023 DONSON forms a dimer that bridges two CMG helicases (double CMG complex) isolated from replicating Xenopus egg extracts. DONSON reconfigures MCM motors in the double CMG, and tethering elements mediating complex formation are essential for replication. DONSON dimerization is required for GINS and MCM engagement in human cells and DNA synthesis in Xenopus egg extracts. Patient mutations disrupting DONSON dimerization impair these functions. Cryo-EM of proteins isolated from replicating Xenopus egg extracts, functional validation with patient mutations, replication assays in Xenopus egg extracts and human cells Molecular cell High 37820732
2023 DONSON is essential for CMG helicase assembly in vertebrates: it physically interacts with GINS and DNA polymerase ε via conserved N-terminal PGY and NPF motifs. DONSON's chromatin association during replication initiation requires the pre-replicative complex, TopBP1, and kinase activities of S-CDK and DDK. Both S-CDK and DDK require DONSON to trigger replication initiation. Xenopus cell-free replication system, depletion/rescue experiments, interaction mapping with domain mutants, kinase dependency assays The EMBO journal High 37458194
2023 DONSON is required for CDC45-MCM-GINS (CMG) helicase assembly during S-phase in mammalian cells. Rapid depletion of DONSON causes disappearance of the CMG helicase from S-phase cells. DONSON binds directly but transiently to CDC45-MCM-GINS during S-phase and is dispensable for MCM2-7 loading onto chromatin in G1, but essential for CMG assembly in S-phase. Rapid protein depletion (auxin-inducible degron) in mouse embryonic stem cells, chromatin fractionation, Co-IP, cell cycle analysis EMBO reports High 37781960
2023 DONSON is required for Cdc45 and GINS association with Mcm2-7 complexes during replication initiation in Xenopus laevis egg extracts. DONSON interacts with TopBP1 in a CDK-dependent manner to facilitate helicase activation. DONSON also forms part of the replisome during elongation. Xenopus laevis cell-free egg extract system, immunodepletion, chromatin binding assays, Co-IP with TopBP1, CDK inhibition experiments Nucleic acids research High 37638758
2020 DONSON-bound replisomes are more frequent in early S phase and associate with euchromatin regions, whereas FANCM-bound replisomes are more prominent in late S phase and favor heterochromatin. These two distinct replisome populations can be detected in both stressed and unstressed cells. ChIP-seq of DONSON and FANCM, iPOND (isolation of proteins on nascent DNA), cell fractionation across S phase, chromatin domain analysis Nature communications High 32769987
2017 DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and Donson is essential for early embryonic development in mice, consistent with an essential conserved role in the cell cycle. RNA-seq identifying aberrant splicing in DONSON from a noncoding variant, in situ hybridization in human embryonic brain, mouse knockout lethality Genome research Medium 28630177
2019 Biallelic DONSON missense variants disrupt the nuclear localization of DONSON protein, providing evidence that nuclear localization is required for DONSON function in DNA replication. Linked-read whole genome sequencing of Meier-Gorlin syndrome patients, functional validation of missense variants by nuclear localization assays in cells Journal of medical genetics Medium 31784481
2000 The DONSON gene is located immediately 3' of the SON gene in a compact gene cluster (GART/SON/DONSON) conserved between mouse and human genomes on chromosome 21q22.1-q22.2, and shows overlapping expression with SON and GART. Genomic sequencing, EST database analysis, expression analysis by Northern blot/RT-PCR Genomics Low 10950926

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. International immunology 860 7903159
1994 Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. Journal of immunology (Baltimore, Md. : 1950) 305 7907107
1995 Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17. Intraductal carcinoma (ductal carcinoma in situ). The National Surgical Adjuvant Breast and Bowel Project Collaborating Investigators. Cancer 270 7882281
1996 From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase. Science (New York, N.Y.) 224 8895467
2019 Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. Molecular cancer 203 30922402
1991 The peptide antibiotic microcin B17 induces double-strand cleavage of DNA mediated by E. coli DNA gyrase. The EMBO journal 158 1846808
1988 The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell. The EMBO journal 154 3049078
1996 Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells. The American journal of pathology 146 8623920
1994 Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Proceedings of the National Academy of Sciences of the United States of America 139 8183941
2004 Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts. Cancer chemotherapy and pharmacology 127 15338192
1997 IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17 mice. American journal of respiratory cell and molecular biology 123 9409560
1996 Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17. Five-year observations concerning lobular carcinoma in situ. Cancer 102 8839545
2001 The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. Journal of molecular biology 98 11292337
2017 Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Nature genetics 94 28191891
1986 Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. Journal of general microbiology 93 3543211
2023 In silico protein interaction screening uncovers DONSON's role in replication initiation. Science (New York, N.Y.) 82 37590370
1996 Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice. The Journal of experimental medicine 73 8642263
1989 DNA sequence, products, and transcriptional pattern of the genes involved in production of the DNA replication inhibitor microcin B17. Journal of bacteriology 72 2644225
1999 Cofactor requirements and reconstitution of microcin B17 synthetase: a multienzyme complex that catalyzes the formation of oxazoles and thiazoles in the antibiotic microcin B17. Biochemistry 70 10200165
1986 Microcin B17 blocks DNA replication and induces the SOS system in Escherichia coli. Journal of general microbiology 68 3086495
1999 Posttranslational heterocyclization of cysteine and serine residues in the antibiotic microcin B17: distributivity and directionality. Biochemistry 65 10569947
1995 sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17. Molecular microbiology 64 8709849
2008 Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes. The Prostate 62 18302198
1986 The DNA replication inhibitor microcin B17 is a forty-three-amino-acid protein containing sixty percent glycine. Proteins 61 3329729
2007 Investigation of the complex I assembly chaperones B17.2L and NDUFAF1 in a cohort of CI deficient patients. Molecular genetics and metabolism 59 17383918
2002 The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation. Journal of bacteriology 56 12029038
1986 Growth phase and ompR regulation of transcription of microcin B17 genes. Journal of bacteriology 56 3017916
1993 Expression of major histocompatibility complex class II antigens and levels of interferon-gamma, tumour necrosis factor, and interleukin-6 in cerebrospinal fluid and serum in Toxoplasma gondii-infected SCID and immunocompetent C.B-17 mice. Immunology 51 8478025
1985 Cloning and mapping of the genetic determinants for microcin B17 production and immunity. Journal of bacteriology 51 2989247
2019 The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents. Journal of molecular biology 50 31181289
1997 The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17. Molecular microbiology 50 9004229
1990 Establishment of a human cutaneous T-cell lymphoma in C.B-17 SCID mice. The Journal of investigative dermatology 50 2307857
2006 The action of the bacterial toxin, microcin B17, on DNA gyrase. Biochimie 49 17276574
1998 Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26. Chemistry & biology 49 9545435
1998 ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. Biochemistry 47 9748332
1993 The maturation pathway of microcin B17, a peptide inhibitor of DNA gyrase. Molecular microbiology 47 8231817
2001 Construction and characterization of mutations at codon 751 of the Escherichia coli gyrB gene that confer resistance to the antimicrobial peptide microcin B17 and alter the activity of DNA gyrase. Journal of bacteriology 46 11222617
1995 Post-translational heterocyclic backbone modifications in the 43-peptide antibiotic microcin B17. Structure elucidation and NMR study of a 13C,15N-labelled gyrase inhibitor. European journal of biochemistry 46 8536683
2019 Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. Molecular cell 45 30661981
1999 In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. Chemistry & biology 45 10322125
1985 Plasmid genes required for microcin B17 production. Journal of bacteriology 44 2993228
1998 Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequence. Biochemistry 43 9521734
1990 mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid. Journal of bacteriology 40 2152912
2020 CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis. Cancer cell international 38 32581651
1998 Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. Chemistry & biology 38 9662507
2017 Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome. Genome research 37 28630177
2020 Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma-induced liver toxicity. Environmental science and pollution research international 36 31916166
2001 In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites. Proceedings of the National Academy of Sciences of the United States of America 36 11427730
2020 DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain. Nature communications 35 32769987
2019 Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice. Environmental toxicology 35 31821727
2023 The structural mechanism of dimeric DONSON in replicative helicase activation. Molecular cell 34 37820732
2019 Linked-read genome sequencing identifies biallelic pathogenic variants in DONSON as a novel cause of Meier-Gorlin syndrome. Journal of medical genetics 34 31784481
2017 The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells. Parasites & vectors 34 28732522
2005 Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase. Biochemistry 34 15766248
1999 Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17. Chemistry & biology 32 10574779
2023 Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation. The EMBO journal 31 37458194
2020 Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats. Oxidative medicine and cellular longevity 31 33194002
2001 Shear stress enhances microcin B17 production in a rotating wall bioreactor, but ethanol stress does not. Applied microbiology and biotechnology 31 11549006
2003 The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyrase. The Journal of biological chemistry 30 12829716
1992 Comparison of polymerase chain reaction and culture for detection of Borrelia burgdorferi in naturally infected Peromyscus leucopus and experimentally infected C.B-17 scid/scid mice. Journal of clinical microbiology 29 1400962
2023 DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation. Nucleic acids research 28 37638758
2000 Expression of the Wilms' tumor suppressor gene, WT1, reduces the tumorigenicity of the leukemic cell line M1 in C.B-17 scid/scid mice. Cancer research 28 10706085
2000 Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Genomics 28 10950926
2013 Fragments of the bacterial toxin microcin B17 as gyrase poisons. PloS one 26 23593482
1987 A human-human hybridoma producing cytotoxic antibody to HLA-B15, cross-reacting with B17, B5, B35 and B18. Tissue antigens 26 2821654
2020 Potential therapy of vitamin B17 against Ehrlich solid tumor induced changes in Interferon gamma, Nuclear factor kappa B, DNA fragmentation, p53, Bcl2, survivin, VEGF and TNF-α Expressions in mice. Pakistan journal of pharmaceutical sciences 24 32122873
1983 A cross-reacting human idiotype (B17) associated with antibodies to N-acetyl-D-glucosamine. Specificity, immunoglobulin class association, and distribution in the population. European journal of immunology 24 6189720
2020 Anticancer Effect of Amygdalin (Vitamin B-17) on Hepatocellular Carcinoma Cell Line (HepG2) in the Presence and Absence of Zinc. Anti-cancer agents in medicinal chemistry 23 31958042
2000 The McbB component of microcin B17 synthetase is a zinc metalloprotein. Biochemistry 22 11123948
2023 DONSON is required for CMG helicase assembly in the mammalian cell cycle. EMBO reports 21 37781960
1996 Co-transfer of B cells converts resistance into susceptibility in T cell-reconstituted, Leishmania major-resistant C.B-17 scid mice by a non-cognate mechanism. International immunology 19 8921436
1988 Coexistence of an MHC chromosomal segment marked by HLA B17,BfS,C4A6,B1,DR7, and DQw9 in different ethnic groups. Human immunology 19 3192430
2019 Biallelic and De Novo Variants in DONSON Reveal a Clinical Spectrum of Cell Cycle-opathies with Microcephaly, Dwarfism and Skeletal Abnormalities. American journal of medical genetics. Part A 18 31407851
2004 Different evolutionary pathway of B*570101 and B*5801 (B17 group) alleles based in intron sequences. Immunogenetics 17 14985876
1996 Administration of rabbit anti-asialo GM1 antiserum facilitates the development of human Epstein-Barr virus-induced lymphoproliferations in xenografted C.B-17 scid/scid mice. Transplantation 17 8610366
1998 Isolation and partial characterization of a thermostable extracellular protease of Bacillus polymyxa B-17. International journal of food microbiology 16 9728684
1998 Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I. Human genetics 16 9760212
1987 Evidence that colicin X is microcin B17. Journal of bacteriology 16 3034869
2019 Amygdalin (Vitamin B17) pretreatment attenuates experimentally induced acute autoimmune hepatitis through reduction of CD4+ cell infiltration. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 15 31100343
2019 The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis and proliferation in mice. Pakistan journal of pharmaceutical sciences 14 32024617
1986 Effects of microcin B17 on microcin B17-immune cells. Journal of general microbiology 14 3519858
2011 A major portion of DNA gyrase inhibitor microcin B17 undergoes an N,O-peptidyl shift during synthesis. The Journal of biological chemistry 13 21628468
2021 Circ-DONSON Knockdown Inhibits Cell Proliferation and Radioresistance of Breast Cancer Cells via Regulating SOX4. Journal of oncology 11 34853591
2003 Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity. Canadian journal of microbiology 11 12897830
1995 Cell counts in peripheral blood and bone marrow of male C.B-17 scid/scid mice. Laboratory animals 11 7603011
2021 Circ-DONSON Facilitates the Malignant Progression of Gastric Cancer Depending on the Regulation of miR-149-5p/LDHA Axis. Biochemical genetics 10 34409524
1999 Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw*0604) associated with B*5701. Tissue antigens 10 10395103
1997 Influence of aeration and carbon source on production of microcin B17 by Escherichia coli ZK650. Applied microbiology and biotechnology 10 9210345
1995 Allelic frequencies of the HLA-B17 antigen group: comparative analysis by serology, IEF and PCR-SSOP typing. Tissue antigens 10 8838345
1983 Analysis of active and inactive complement C4 complotypes associated with subtypes of HLA-B17 in different racial groups. American journal of human genetics 10 6837577
2022 Microcephalic primordial dwarfism with predominant Meier-Gorlin phenotype, ichthyosis, and multiple joint deformities-Further expansion of DONSON Cell Cycle-opathy phenotypic spectrum. American journal of medical genetics. Part A 8 35298084
2014 Synthesis of full length and truncated microcin B17 analogues as DNA gyrase poisons. Organic & biomolecular chemistry 8 24448886
1995 Engraftment of precursor lesions of human cutaneous neoplasms onto C.B-17 SCID mice: a useful in vivo experimental model of carcinogenesis in human skin. Archives of dermatological research 8 7598527
2023 The Postulated Mechanism of Action of Amygdalin (Vitamin B17) on Cancer Cells. Anti-cancer agents in medicinal chemistry 7 36424774
2020 Downstream neighbor of SON (DONSON) is associated with unfavorable survival across diverse cancers with oncogenic properties in clear cell renal cell carcinoma. Translational oncology 7 32805676
2020 Downstream Neighbor of SON (DONSON) Expression Is Enhanced in Phenotypically Aggressive Prostate Cancers. Cancers 7 33228112
2001 Coxiella burnetii infection in C.B-17 scid-bg mice xenotransplanted with fetal bovine tissue. Comparative medicine 7 11924795
2018 A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway. Cancer medicine 6 29953738
2012 Comprehensive evaluation of two HLA-B17 monoclonal antibodies for flow cytometry-based HLA-B57/B58 screening prior to abacavir prescription. International journal of immunogenetics 6 23280011
1982 Clonal analysis of a human lymphoblastoid cell line (B17) secreting antibody to N-acetyl-D-glucosamine. Immunobiology 6 6293967