Affinage

DND1

Dead end protein homolog 1 · UniProt Q8IYX4

Length
353 aa
Mass
38.7 kDa
Annotated
2026-04-28
49 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DND1 is a vertebrate-conserved RNA-binding protein that governs germ cell survival, differentiation, and tumor suppression by post-transcriptionally regulating target mRNAs through multiple mechanisms. DND1 binds uridine-rich and AUGAAUU motifs in mRNA 3′UTRs, where it can either protect transcripts from miRNA-mediated repression—as demonstrated for p27/p21 cell-cycle inhibitors and Ezh2—or destabilize them by recruiting the CCR4-NOT deadenylase complex in partnership with NANOS2/NANOS3 (PMID:18155131, PMID:28297718, PMID:21115610, PMID:35705038). The DND1–NANOS3 complex forms a ternary structure on a specific AUGAAUU heptanucleotide, creating a continuous RNA-binding surface that confers sequence-specific target selection for mRNAs encoding cell-cycle drivers (CDK1), pluripotency factors, and chromatin regulators, and also operates in P-bodies to suppress translation of targets such as SOX4 via the translational repressor 4E-T (PMID:41040373, PMID:40410171, PMID:31253634). Structurally, the RRM2 domain adopts a non-canonical fold stabilized by 3D domain-swapped dimerization, and DND1 localizes target mRNAs to the periphery of germ granule condensates where ribosomes reside, linking RNA compartmentalization to translational control and germ cell fate (PMID:33860980, PMID:37463577). Loss-of-function mutations in DND1 deplete primordial germ cells and predispose to testicular germ cell tumors in mice (PMID:30275529, PMID:29378702).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2007 High

    Establishing that DND1 functions as an RNA-binding protein that blocks miRNA access to 3′UTR sites resolved how germ cell mRNAs escape miRNA-mediated silencing, founding the field of DND1 biology.

    Evidence RNA binding assays and miRNA-reporter functional assays in human cells and zebrafish PGCs

    PMID:18155131

    Open questions at the time
    • Mechanism by which DND1 physically occludes miRNA sites not resolved at atomic level
    • Whether miRNA-blocking is the sole or dominant mode of DND1 action was unknown
  2. 2008 Medium

    Identification of APOBEC3 as a physical interaction partner of DND1 raised the possibility that DND1 participates in RNA editing or innate immune defense in germ cells, though the functional consequence remained unclear.

    Evidence Co-immunoprecipitation from transfected cells and mouse gonad lysates with co-localization by fluorescence microscopy

    PMID:18509452

    Open questions at the time
    • No direct binding demonstrated (co-IP only)
    • Functional consequence of DND1–APOBEC3 interaction not established
    • Not independently replicated
  3. 2010 High

    Demonstrating that DND1 directly binds and promotes translation of p27/p21 mRNAs explained how germ cells enter mitotic arrest, connecting DND1's RNA-binding activity to cell-cycle control and teratoma suppression.

    Evidence RIP for direct mRNA binding and western blot for p27/p21 protein levels in Dnd1(Ter/Ter) mouse germ cells across strain backgrounds

    PMID:21115610

    Open questions at the time
    • Whether stabilization versus translational enhancement is the primary mechanism was not distinguished
    • Contribution of miRNA-blocking versus other modes at p21/p27 3′UTRs unclear
  4. 2011 Medium

    Cataloguing DND1-associated mRNAs in embryonic stem cells—including pluripotency factors (OCT4, SOX2, NANOG), cell-cycle regulators, and apoptotic factors—expanded the known target repertoire beyond germ cells.

    Evidence RIP followed by RT-PCR in HA-DND1-expressing human ES cells

    PMID:21851623

    Open questions at the time
    • Single method (RIP-RT-PCR) without crosslinking or transcriptomic scale
    • Functional consequence of binding not tested for most targets
  5. 2012 Medium

    Linking DND1 to epigenetic regulation through protection of Ezh2 mRNA from miR-26a revealed that DND1 loss reduces H3K27me3, de-represses Ccnd1, and drives teratoma formation—connecting RNA-level regulation to chromatin state.

    Evidence miRNA reporter assays, immunostaining for H3K27me3/Ezh2 in Dnd1 mutant PGCs, rescue experiments

    PMID:29378702

    Open questions at the time
    • Single-lab study without independent replication
    • Whether Ezh2 is a direct miRNA-blocking target or indirectly regulated was not fully resolved
  6. 2017 High

    CLIP-seq and CCR4-NOT co-immunoprecipitation overturned the view of DND1 as solely a stabilizer, establishing that DND1 also destabilizes target mRNAs by directly recruiting the CCR4-NOT deadenylase complex, with target engagement dependent on the number of UU(A/U) binding sites.

    Evidence CLIP-seq, transcriptomics, Co-IP of CCR4-NOT, and Dnd1 knockout mice with phenotypic analysis

    PMID:28297718

    Open questions at the time
    • How DND1 switches between mRNA-stabilizing and mRNA-destabilizing modes on different targets remained unknown
    • Direct structural basis of CCR4-NOT recruitment by DND1 not determined
  7. 2017 Medium

    Extension of DND1's mRNA-protective function to somatic cancer contexts—stabilizing Bim mRNA against miR-221 in breast cancer and LATS2 mRNA to activate Hippo signaling in hepatocellular carcinoma—demonstrated that DND1's miRNA-antagonizing mechanism operates beyond germ cells.

    Evidence 3′UTR mutagenesis and knockdown/overexpression functional assays in MCF-7 and HCC cell lines

    PMID:28191469 PMID:28593479

    Open questions at the time
    • Both studies from single laboratories
    • Endogenous DND1 expression levels in these somatic cancers not thoroughly characterized
  8. 2019 High

    A CRISPR base-editing screen identified specific DND1 residues essential for protein stability and protein–protein interactions that are absolutely required for primordial germ cell survival, establishing structure–function constraints in vivo.

    Evidence CRISPR-Cas9 base editing in mice with PGC quantification, protein stability and interaction assays

    PMID:30275529

    Open questions at the time
    • Identities of the disrupted protein–protein interactions were not all determined
    • Whether affected residues map to the RRM1, RRM2, or linker regions was not fully resolved structurally
  9. 2019 High

    Time-resolved transcriptomic analysis of Dnd1-mutant germ cells revealed a dual temporal program: DND1 first suppresses pluripotency/cell-cycle gene networks and later promotes expression of epigenetic modifiers during male germ cell differentiation.

    Evidence DO-RIP-seq for direct targets combined with RNA-seq time course (E12.5–E14.5) in Dnd1 mutant mice

    PMID:31253634

    Open questions at the time
    • Mechanism by which DND1 switches from suppressive to activating roles at different developmental stages not resolved
    • Whether partner proteins change between phases was not tested
  10. 2021 High

    Solving the crystal structure of the RRM2 domain revealed a non-canonical RRM fold stabilized by 3D domain-swapped dimerization, providing the first atomic-level insight into DND1 architecture.

    Evidence X-ray crystallography at 2.3 Å, validated by NMR spectroscopy and molecular dynamics simulations

    PMID:33860980

    Open questions at the time
    • Structure of full-length DND1 or RRM1 domain not determined
    • RNA-binding mode of RRM2 not captured in this structure
  11. 2022 High

    Reconstitution of NANOS2–DND1 cooperation in somatic cells demonstrated that NANOS2 is required both for CCR4-NOT recruitment and for target mRNA selection—not merely for effector recruitment—establishing a cooperative target-recognition paradigm.

    Evidence Co-IP, domain fusion/deletion constructs, and mRNA repression reporter assays in a somatic cell system

    PMID:35705038

    Open questions at the time
    • Structural basis of how NANOS2 contributes to RNA selectivity was not yet determined
    • Whether NANOS3 operates identically to NANOS2 in this mechanism was unknown
  12. 2023 High

    DND1 was shown to organize mRNA spatial positioning within phase-separated germ granules, localizing nanos3 RNA to the ribosome-associated periphery; loss of DND1 relocates mRNA to the translationally silent interior, linking RNA compartmentalization to germ cell fate.

    Evidence 3D structural analysis of germ granules and live imaging in zebrafish with Dnd1 loss-of-function

    PMID:37463577

    Open questions at the time
    • Whether DND1 directly drives phase separation or is recruited to pre-existing condensates not determined
    • Generality beyond nanos3 mRNA not established
  13. 2023 High

    Endogenous RIP-seq from knock-in DND1-GFP mice identified new target categories during G0 arrest including Dnmts, Hdacs, Tudor-domain proteins, and ribosomal/Golgi mRNAs, broadening the regulatory scope of DND1 in male germ cell quiescence.

    Evidence RIP-seq from DND1-GFP knock-in mice with flow-sorted germ cell populations

    PMID:36857387

    Open questions at the time
    • Functional validation of individual targets from this expanded list largely pending
    • Whether DND1 stabilizes or destabilizes each category not determined
  14. 2025 High

    A 1.7-Å ternary crystal structure of the DND1–NANOS3–RNA complex revealed that both proteins create a continuous binding surface recognizing the AUGAAUU heptanucleotide, and in vivo genome editing of this element in Cdk1 abolished its repression, providing the definitive structural and genetic mechanism for cooperative target selection.

    Evidence Tandem PAR-CLIP, 1.7-Å crystal structure, CRISPR editing of the N3-DRE in Cdk1 in mouse PGCs, transcriptomics (preprint)

    PMID:41040373

    Open questions at the time
    • Preprint; awaits peer review
    • How many of the ~hundreds of predicted N3-DRE targets are functionally regulated in vivo is unknown
    • Structural basis of the alternative miRNA-blocking mode not captured
  15. 2025 High

    Identification of 4E-T as the translational repression effector bridged by NANOS3 between DND1 and the translation machinery in P-bodies revealed a third mechanistic mode—translational suppression of SOX4—functioning as a brake on human PGC specification.

    Evidence Reciprocal Co-IP of DND1–NANOS3–4E-T complex, P-body localization imaging, loss-of-function in human PGC-like cells

    PMID:40410171

    Open questions at the time
    • Whether 4E-T and CCR4-NOT recruitment are mutually exclusive or sequential on the same targets is unresolved
    • Relationship between P-body localization and germ granule localization of DND1 not clarified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular logic determining whether DND1 stabilizes (miRNA-blocking mode), destabilizes (CCR4-NOT deadenylation mode), or translationally represses (4E-T mode) a given target mRNA remains unknown, as does the full-length structure of DND1 and its conformational dynamics upon partner and RNA engagement.
  • No structure of full-length DND1 or DND1–RNA in the miRNA-blocking conformation
  • Switch mechanism between stabilizing and destabilizing modes unresolved
  • Relative contributions of NANOS2 vs NANOS3 partnership in different developmental windows not systematically compared

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 9 GO:0098772 molecular function regulator activity 5 GO:0140098 catalytic activity, acting on RNA 3
Localization
GO:0005829 cytosol 3 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-8953854 Metabolism of RNA 6 R-HSA-1266738 Developmental Biology 4 R-HSA-1640170 Cell Cycle 3 R-HSA-5357801 Programmed Cell Death 2
Partners
4E-TAPOBEC3CNOT1NANOS2NANOS3RBM38
Complex memberships
DND1–NANOS2–CCR4-NOTDND1–NANOS3–4E-T

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 DND1 binds uridine-rich regions in mRNA 3'UTRs and blocks miRNA access to target sites, counteracting miRNA-mediated repression of target mRNAs in human cells and zebrafish primordial germ cells RNA binding assays, functional reporter assays, miRNA inhibition assays in human cells and zebrafish PGCs Cell High 18155131
2017 DND1 binds a UU(A/U) trinucleotide motif in 3'UTRs of target mRNAs and destabilizes them through direct recruitment of the CCR4-NOT deadenylase complex, with suppression extent dependent on number of binding sites; target mRNAs include apoptosis regulators and pluripotency pathway modulators CLIP-seq, transcriptomic analysis, co-immunoprecipitation of CCR4-NOT complex, knockout mouse models with phenotypic readout Nature High 28297718
2010 DND1 directly binds mRNAs encoding cell-cycle inhibitors p27(Kip1) and p21(Cip1) and promotes their translation; loss of DND1 leads to decreased p27 and p21 protein and failure of male germ cells to enter mitotic arrest (G0) RNA binding assays (RIP), western blot of target proteins in Dnd1(Ter/Ter) mouse germ cells, genetic epistasis with strain backgrounds Development High 21115610
2008 DND1 physically interacts with mouse APOBEC3 protein; the two proteins co-localize to peri-nuclear cytoplasmic sites when co-expressed and co-immunoprecipitate from both transfected mammalian cells and mouse gonad lysates Co-immunoprecipitation from mammalian cells and mouse gonads, fluorescence microscopy of tagged proteins PloS one Medium 18509452
2011 DND1 associates with mRNAs encoding pluripotency factors (OCT4, SOX2, NANOG, LIN28), cell cycle regulators (TP53, LATS2), and apoptotic factors (BCLX, BAX) in embryonic stem cells, as identified by ribonucleoprotein immunoprecipitation RIP (ribonucleoprotein immunoprecipitation) followed by RT-PCR in HA-tagged DND1-expressing human ES cells BMC molecular biology Medium 21851623
2012 DND1 suppresses miR-26a-mediated inhibition of Ezh2 expression in primordial germ cells; DND1 deficiency leads to decreased H3K27me3 (via reduced Ezh2) and de-repression of Ccnd1, linking DND1 to epigenetic control of cell cycle and teratoma suppression miRNA reporter assays, western blot and immunostaining for H3K27me3/Ezh2 in Dnd1 mutant mouse PGCs, rescue experiments with Ezh2 and Ccnd1 Biology open Medium 29378702
2017 DND1 binds to the 3'UTR of Bim mRNA at the miR-221 binding site, stabilizing Bim mRNA and antagonizing miR-221-mediated repression of Bim, thereby promoting apoptosis in breast cancer cells DND1 knockdown in MCF-7 cells, mRNA stability assay, 3'UTR mutation at miR-221 site, western blot BioMed research international Medium 28191469
2017 DND1 binds the 3'UTR of LATS2 mRNA and elevates LATS2 stability and expression, leading to YAP phosphorylation and cytoplasmic retention, thereby activating the Hippo pathway and suppressing EMT and cancer stem cell traits in hepatocellular carcinoma cells RNA binding assay (3'UTR binding), western blot for LATS2/YAP pathway, DND1 knockdown/overexpression functional assays in HCC cells Biotechnology letters Medium 28593479
2019 CRISPR base-editing screen identified four DND1 missense mutations that completely deplete primordial germ cells in mice by disrupting DND1 protein stability and protein-protein interactions CRISPR-Cas9 base-editing in mice, PGC counting, protein stability and interaction assays Nature cell biology High 30275529
2019 DND1 controls downregulation of pluripotency/cell cycle genes (including mTor, Hippo, Bmp/Nodal pathway elements) and also targets chromatin regulators that are activated during male germ cell differentiation; DND1 functions sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers DO-RIP-Seq to identify direct targets, transcriptome sequencing of Dnd1 mutant male germ cells at E12.5-E14.5 Development High 31253634
2021 Crystal structure of human DND1-RRM2 domain at 2.3 Å reveals a non-canonical RRM fold maintained by 3D domain-swapped dimerization between β1 and β4 strands across protomers; NMR and MD simulations delineated molecular basis of dimer stability X-ray crystallography, NMR spectroscopy, molecular dynamics simulations Protein science High 33860980
2022 NANOS2 interacts with RNA-bound DND1 and recruits the CNOT deadenylase complex to target mRNAs; NANOS2 is required not only for CNOT recruitment but also for target mRNA selection in cooperation with DND1 — a fusion of the CNOT1-binding NANOS2 domain with DND1 alone fails to repress targets Co-immunoprecipitation, somatic cell reporter system for NANOS2-DND1 function, domain fusion/deletion constructs, mRNA repression assays Cell reports High 35705038
2023 In zebrafish germ granules, DND1 is essential for localizing nanos3 RNA to the periphery of phase-separated condensates where ribosomes are present; in the absence of DND1, nanos3 RNA translocates to the granule interior away from ribosomes, correlating with loss of germ cell fate 3D in vivo structural analysis of germ granules, live imaging, translational inhibition experiments, Dnd1 loss-of-function in zebrafish Developmental cell High 37463577
2023 DND1 targets during male germ cell G0 arrest include DNA methyltransferases (Dnmts), histone deacetylases (Hdacs), Tudor domain proteins, actin-dependent regulators (Smarcs), and ribosomal/Golgi proteins, as identified by RIP-sequencing from knock-in DND1-GFP mice; a subpopulation of pro-spermatogonia expresses elevated DND1 Knock-in DND1-GFP mouse line, RIP-sequencing with anti-GFP antibodies, RNA-seq time course, flow cytometry cell sorting PLoS genetics High 36857387
2025 DND1 forms a complex with NANOS3 that recognizes an AUGAAUU heptanucleotide motif (N3-DRE) in target mRNA 3'UTRs; crystal structure at 1.7 Å of the ternary DND1-NANOS3-RNA complex reveals a continuous RNA-binding surface enabling high-affinity sequence-specific recognition; N3-DRE-containing mRNAs including CDK1 are upregulated in DND1- or NANOS3-deficient germ cells, and genome editing of the N3-DRE in Cdk1 abolishes its repression in mouse PGCs in vivo Tandem PAR-CLIP, 1.7-Å crystal structure of ternary complex, in vivo genome editing of N3-DRE element, transcriptomics of mutant germ cells bioRxivpreprint High 41040373
2025 DND1 forms a complex with NANOS3 to suppress translation of SOX4 mRNAs in processing bodies (P-bodies), with NANOS3 mediating the interaction between DND1 and the translational repressor 4E-T; this DND1-NANOS3 complex acts as a 'braking system' restricting primordial germ cell specification in humans Co-immunoprecipitation of DND1-NANOS3-4E-T complex, RIP analysis of bound mRNAs, P-body localization imaging, DND1/NANOS3 loss-of-function in human PGC-like cells, SOX4 reporter assays Nature communications High 40410171
2015 DND1 and RBM38 stabilize p21(CIP1) mRNA in AML cells; knockdown of DND1 in NB4 APL cells significantly attenuates neutrophil differentiation and decreases p21(CIP1) mRNA expression shRNA knockdown in NB4 cells, qRT-PCR of p21(CIP1), differentiation assays Leukemia research Medium 26740055
2024 DND1 negatively regulates CLIC4 mRNA levels in prostate cancer cells; DND1 protein binds CLIC4 mRNA, and DND1 silencing increases CLIC4 expression while suppressing proliferation, migration, invasion, and EMT Bioinformatic prediction of DND1-CLIC4 mRNA interaction, western blot and qRT-PCR after DND1 knockdown, rescue experiments with CLIC4 depletion Histology and histopathology Low 38390782
2024 circFCHO2 directly binds DND1 protein in melanoma cells, sequestering DND1 and reversing its inhibition of the PI3K/AKT signaling pathway, thereby promoting melanoma cell proliferation, migration, and invasion FISH, RNA pulldown, RIP, western blotting for PI3K/AKT pathway markers, functional assays with circFCHO2 overexpression and DND1 binding Cell biology and toxicology Medium 38311675

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 568 18155131
2000 The Arabidopsis dnd1 "defense, no death" gene encodes a mutated cyclic nucleotide-gated ion channel. Proceedings of the National Academy of Sciences of the United States of America 401 10900264
1998 Gene-for-gene disease resistance without the hypersensitive response in Arabidopsis dnd1 mutant. Proceedings of the National Academy of Sciences of the United States of America 313 9636234
2017 DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Nature 112 28297718
2010 Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development (Cambridge, England) 80 21115610
2010 MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma. FEBS letters 75 20816961
2012 The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. Oncogene 62 22614019
2009 BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Developmental biology 62 19389346
2018 CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development. Nature cell biology 61 30275529
2015 Down-regulation of Arabidopsis DND1 orthologs in potato and tomato leads to broad-spectrum resistance to late blight and powdery mildew. Transgenic research 35 26577903
2008 Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes, chromosomes & cancer 32 18069663
2015 The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation. Leukemia research 29 26740055
2019 The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. Development (Cambridge, England) 28 31253634
2023 Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1. Developmental cell 27 37463577
2017 Silencing of DND1 in potato and tomato impedes conidial germination, attachment and hyphal growth of Botrytis cinerea. BMC plant biology 27 29212470
2011 Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. BMC molecular biology 27 21851623
2008 Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1). PloS one 25 18509452
2017 RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site. BioMed research international 23 28191469
2012 The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders. PloS one 23 22655094
2007 Disturbance of the Ca(2+)/calmodulin-dependent signalling pathway is responsible for the resistance of Arabidopsis dnd1 against Pectobacterium carotovorum infection. Molecular plant pathology 23 20507535
2019 Dnd1 Knockout in Sturgeons By CRISPR/Cas9 Generates Germ Cell Free Host for Surrogate Production. Animals : an open access journal from MDPI 22 30999629
2012 Expression of RNA-binding proteins DND1 and FXR1 in the porcine ovary, and during oocyte maturation and early embryo development. Molecular reproduction and development 21 22730312
2017 RNA-binding protein Dnd1 inhibits epithelial-mesenchymal transition and cancer stem cell-related traits on hepatocellular carcinoma cells. Biotechnology letters 20 28593479
2013 Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC genetics 20 23773267
2018 Dnd1-mediated epigenetic control of teratoma formation in mouse. Biology open 13 29378702
2019 MicroRNA-24 regulates the growth and chemosensitivity of the human colorectal cancer cells by targeting RNA-binding protein DND1. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 10 31646794
2011 Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells. Experimental cell research 10 21570390
2022 A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1. Cell reports 8 35705038
2021 The Role of DND1 in Cancers. Cancers 8 34359581
2020 MicroRNA-24 inhibits the proliferation, migration and invasion and enhances chemosensitivity of human gastric cancer by targeting DND1. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 8 32521898
2024 Less is more: CRISPR/Cas9-based mutations in DND1 gene enhance tomato resistance to powdery mildew with low fitness costs. BMC plant biology 7 39123110
2022 A homozygous missense variant in DND1 causes non-obstructive azoospermia in humans. Frontiers in genetics 6 36246621
2024 Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1. Cell biology and toxicology 5 38311675
2023 Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Human reproduction (Oxford, England) 5 36807972
2023 Effects of CRISPR/Cas9-mediated dnd1 knockout impairs gonadal development in striped catfish. Animal : an international journal of animal bioscience 5 38103430
2021 Heading towards a dead end: The role of DND1 in germ line differentiation of human iPSCs. PloS one 5 34653201
2025 RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage. Nature communications 4 40410171
2023 Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics 4 36713075
2022 In silico analysis of DND1 and its co-expressed genes in human cancers. Biochemistry and biophysics reports 4 35059511
2021 Human DND1-RRM2 forms a non-canonical domain swapped dimer. Protein science : a publication of the Protein Society 4 33860980
2010 Screening for germline DND1 mutations in testicular cancer patients. Familial cancer 4 20411342
2024 RNA-binding protein DND1 participates in migration, invasion, and EMT of prostate cancer cells by degrading CLIC4. Histology and histopathology 3 38390782
2019 Generation of a novel mouse strain with conditional, cell-type specific, expression of DND1. Genesis (New York, N.Y. : 2000) 3 31513344
2023 The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation. PLoS genetics 2 36857387
2023 Spatial organization and function of RNA molecules within phase-separated condensates are controlled by Dnd1. bioRxiv : the preprint server for biology 2 37461638
2025 Generation of primordial germ cell-like cells by two germ plasm components, dnd1 and nanos3, in medaka (Oryzias latipes). iScience 1 40060892
2025 The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3' UTRs. bioRxiv : the preprint server for biology 0 41040373
2024 Transcriptome, hormonal, and secondary metabolite changes in leaves of DEFENSE NO DEATH 1 (DND1) silenced potato plants. Scientific reports 0 39232097
2019 Author Correction: CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development. Nature cell biology 0 30718859