Affinage

DNAH6

Dynein axonemal heavy chain 6 · UniProt Q9C0G6

Length
4158 aa
Mass
476.0 kDa
Annotated
2026-04-28
100 papers in source corpus 8 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DNAH6 is an axonemal inner dynein arm (IDA) heavy chain required for motile cilia and sperm flagella function, with roles in left-right body patterning, airway mucociliary clearance, and sperm motility. In respiratory cilia, DNAH6 axonemal assembly depends on the CCDC39/CCDC40 molecular ruler complex, and in sperm flagella it is assembled through a DNAH3-dependent IDA pathway; loss of DNAH6 causes absence of inner dynein arms and radial spokes, acrosome defects, and asthenoteratozoospermia (PMID:39056782, PMID:39503742, PMID:37594300). DNAH6 exhibits oligogenic epistatic interactions with other ciliary dynein genes (DNAH5, DNAI1), whereby trans-heterozygous loss produces heterotaxy through disrupted motile cilia in Kupffer's vesicle and respiratory epithelia (PMID:26918822). Loss-of-function mutations in DNAH6 cause primary ciliary dyskinesia-like ciliary dysfunction with heterotaxy and male infertility (PMID:26918822, PMID:37424858).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 2016 High

    Establishing DNAH6 as essential for motile cilia function and left-right patterning resolved its basic biological requirement: knockdown in zebrafish disrupted Kupffer's vesicle cilia and caused heterotaxy, while knockdown in mammalian respiratory epithelia impaired cilia motility, demonstrating a conserved role across vertebrates.

    Evidence Morpholino knockdown in zebrafish and shRNA knockdown in human/mouse respiratory epithelia with laterality and cilia motility phenotyping

    PMID:26918822

    Open questions at the time
    • Whether DNAH6 functions in the outer or inner dynein arm was not resolved
    • Structural position of DNAH6 within the axonemal repeat was unknown
    • Mechanism by which DNAH6 loss disrupts cilia beat was not defined
  2. 2016 High

    Demonstrating oligogenic epistasis between DNAH6 and DNAH5/DNAI1 established that heterotaxy can arise from combinatorial subclinical defects in multiple dynein genes, expanding the genetic architecture of ciliopathies beyond monogenic models.

    Evidence Subthreshold double-morpholino knockdown in zebrafish and siRNA knockdown in heterozygous Dnah5/Dnai1 mutant mouse respiratory epithelia

    PMID:26918822

    Open questions at the time
    • Physical basis for the epistatic interaction (e.g., shared complex or functional redundancy) was not determined
    • Whether oligogenic interactions extend to additional dynein or ciliary genes was untested
  3. 2018 Medium

    Localizing DNAH6 protein to the neck region of normal spermatozoa and linking compound heterozygous variants to complete protein loss and sperm head anomalies provided the first evidence of a sperm-specific role.

    Evidence Immunofluorescence and qRT-PCR in human spermatozoa from a single infertile patient with compound heterozygous DNAH6 variants

    PMID:29356036

    Open questions at the time
    • Single patient without functional rescue or independent cohort replication
    • Mechanism linking a dynein heavy chain to sperm head/acrosome morphology was unexplained
    • Axonemal ultrastructure was not examined
  4. 2023 Medium

    Defining the ultrastructural consequences of DNAH6 loss in sperm — absence of inner dynein arms, radial spokes, and acrosome defects — placed DNAH6 within the IDA compartment and revealed an unexpectedly broad structural requirement extending beyond the dynein arm itself.

    Evidence Transmission electron microscopy, immunofluorescence, and Western blot in spermatozoa from DNAH6-variant patients

    PMID:37424858 PMID:37594300

    Open questions at the time
    • Whether radial spoke and acrosome defects are direct or secondary consequences of IDA loss was not resolved
    • No animal knockout model confirmed these sperm phenotypes
    • Precise IDA isoform identity of DNAH6 (e.g., IDA-f vs. IDA-d) was not established
  5. 2024 High

    Establishing that DNAH6 axonemal assembly in respiratory cilia depends on the CCDC39/CCDC40 molecular ruler, and in sperm flagella depends on DNAH3, defined the hierarchical assembly pathway positioning DNAH6 downstream of specific scaffolding and co-heavy-chain components.

    Evidence Immunofluorescence of respiratory cilia in 51 CCDC39/CCDC40-variant individuals; immunofluorescence and Western blot of sperm from DNAH3-deficient patients and Dnah3 KO mice

    PMID:39056782 PMID:39503742

    Open questions at the time
    • Whether DNAH6 directly binds CCDC39/CCDC40 or DNAH3, or is lost indirectly, is unknown
    • No biochemical reconstitution of the IDA assembly hierarchy exists
    • Whether the same assembly dependencies apply in embryonic nodal cilia was not tested
  6. 2024 Medium

    Negative epistasis data showing that DNAH11 (ODA) loss does not affect DNAH6 levels confirmed DNAH6 resides exclusively in the inner dynein arm compartment, independent of outer dynein arm integrity.

    Evidence Western blot and immunofluorescence of sperm from DNAH11-variant patients

    PMID:39256880

    Open questions at the time
    • Only tested in sperm; whether IDA/ODA independence holds in respiratory or nodal cilia was not assessed
    • No direct structural data (cryo-ET) positioning DNAH6 within the 96 nm axonemal repeat

Open questions

Synthesis pass · forward-looking unresolved questions
  • The precise position of DNAH6 within the IDA substructure (specific IDA isoform), its direct binding partners within the dynein complex, and the mechanism by which its loss leads to secondary radial spoke and acrosome defects remain unresolved.
  • No cryo-electron tomography or high-resolution structural data for DNAH6 in the axoneme
  • No biochemical reconstitution of DNAH6-containing inner dynein arm complexes
  • Molecular mechanism of oligogenic epistasis with DNAH5/DNAI1 is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 3
Localization
GO:0005929 cilium 5 GO:0005856 cytoskeleton 3
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-1474165 Reproduction 2 R-HSA-1852241 Organelle biogenesis and maintenance 2
Partners
CCDC39CCDC40DNAH1DNAH3DNAH5DNAI1DNALI1
Complex memberships
Inner dynein arm (IDA)

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 DNAH6 is required for motile cilia function in left-right patterning; dnah6 morpholino knockdown in zebrafish disrupted motile cilia in Kupffer's vesicle causing heterotaxy with abnormal cardiac/gut looping, and DNAH6 shRNA knockdown disrupted motile cilia in human and mouse respiratory epithelia. Morpholino knockdown in zebrafish (cilia motility assay, organ laterality phenotype); shRNA knockdown in human and mouse respiratory epithelia PLoS genetics High 26918822
2016 Trans-heterozygous genetic interactions between DNAH6 and other PCD genes (DNAH5, DNAI1) can cause heterotaxy; subthreshold double-morpholino knockdown in zebrafish and siRNA knockdown in heterozygous Dnah5 or Dnai1 mutant mouse respiratory epithelia disrupted motile cilia function, establishing an oligogenic epistatic relationship. Subthreshold double-morpholino knockdown in zebrafish; siRNA knockdown in heterozygous mutant mouse respiratory epithelia; genetic epistasis PLoS genetics High 26918822
2018 DNAH6 protein localizes to the neck region of spermatozoa in normal controls; compound heterozygous DNAH6 variants in an infertile male caused complete absence of DNAH6 protein and mRNA in spermatozoa, associated with sperm head anomalies (acephalic and globozoospermic sperm). Immunofluorescence localization in human spermatozoa; qRT-PCR; whole-exome sequencing with Sanger validation Andrologia Medium 29356036
2023 DNAH6 variants cause absence of inner dynein arms and radial spokes in sperm flagella, as well as acrosome defects and abnormal chromatin compaction; decreased levels of component proteins in these defective structures were confirmed by Western blot, indicating DNAH6 is required for axonemal inner dynein arm and radial spoke assembly and acrosome biogenesis in sperm. Transmission electron microscopy of sperm ultrastructure; immunofluorescence; Western blot; whole-exome sequencing Asian journal of andrology Medium 37594300
2023 A homozygous frameshift mutation in DNAH6 (c.2823dupT) causes abnormal DNAH6 mRNA expression (premature termination and NMD) and loss of DNAH6 protein in sperm, resulting in multiple morphological and ultrastructural abnormalities of spermatozoa (asthenoteratozoospermia). Whole-exome sequencing; Sanger sequencing; qRT-PCR; immunofluorescence; scanning and transmission electron microscopy Frontiers in endocrinology Medium 37424858
2024 DNAH6 is an inner dynein arm (IDA) heavy chain component in sperm flagella; loss of DNAH3 in patients and Dnah3 knockout mice causes secondary loss of DNAH6 (along with DNAH1 and DNALI1) from sperm flagella, placing DNAH6 within a DNAH3-dependent IDA assembly pathway. Immunofluorescence of sperm flagella in DNAH3-deficient patients and Dnah3 KO mice; Western blot; whole-exome sequencing eLife Medium 39503742
2024 DNAH6 is an IDA heavy chain in respiratory ciliary axonemes; disease-causing variants in CCDC39 and CCDC40 (components of the 96 nm axonemal ruler complex) cause conspicuous absence of DNAH6 (along with DNAH1 and DNAH7) from respiratory ciliary axonemes, demonstrating that DNAH6 assembly into cilia depends on the CCDC39/CCDC40 molecular ruler. Immunofluorescence analysis of respiratory ciliary axonemes in a cohort of 51 individuals with CCDC39/CCDC40 variants; next-generation sequencing Cells High 39056782
2024 DNAH11 variants cause loss of outer dynein arm proteins and asthenoteratozoospermia but do not affect inner dynein arm proteins DNAH1 and DNAH6, establishing that DNAH6 resides specifically in the inner dynein arm compartment of sperm flagella and is not downstream of ODA assembly. Western blot and immunofluorescence of sperm from DNAH11-variant patients; scanning and transmission electron microscopy Human genomics Medium 39256880
2024 DNAH6 null deletion is significantly more frequent in asthenozoospermia patients than fertile controls (45% vs 11.7%), supporting a functional role of DNAH6 in sperm motility. PCR-based detection of null deletion in genomic DNA from asthenozoospermia patients vs. controls BMC urology Low 39192248

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS genetics 95 26918822
1996 Structure of aquaporin-2 vasopressin water channel. The Journal of biological chemistry 80 8617798
1994 Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. The Journal of biological chemistry 75 7961705
2016 Copper complexes based on chiral Schiff-base ligands: DNA/BSA binding ability, DNA cleavage activity, cytotoxicity and mechanism of apoptosis. European journal of medicinal chemistry 54 26994692
2014 Derivation of structure-activity relationships from the anticancer properties of ruthenium(II) arene complexes with 2-aryldiazole ligands. Inorganic chemistry 53 25302401
2019 Maintenance Therapies for Hodgkin and Non-Hodgkin Lymphomas After Autologous Transplantation: A Consensus Project of ASBMT, CIBMTR, and the Lymphoma Working Party of EBMT. JAMA oncology 49 30816957
2020 Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention. Journal of ovarian research 47 32962729
2012 Organometallic ruthenium(II) complexes: synthesis, structure and influence of substitution at azomethine carbon towards DNA/BSA binding, radical scavenging and cytotoxicity. European journal of medicinal chemistry 45 22901409
2018 DNAH6 is a novel candidate gene associated with sperm head anomaly. Andrologia 43 29356036
2003 Correlations between complexation modes and redox activities of Ni(II)-GSH complexes. Chemical research in toxicology 42 12870888
2009 Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery. Journal of the American Society of Nephrology : JASN 39 19406978
2003 Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism. The Biochemical journal 38 14510638
2012 Synthesis of novel heterobimetallic copper(I) hydrazone Schiff base complexes: a comparative study on the effect of heterocyclic hydrazides towards interaction with DNA/protein, free radical scavenging and cytotoxicity. Metallomics : integrated biometal science 37 22487989
2008 Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2. Diabetologia 35 18758746
2020 The HD-Zip IV transcription factor SlHDZIV8 controls multicellular trichome morphology by regulating the expression of Hairless-2. Journal of experimental botany 34 32930788
2019 Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation. Journal of inorganic biochemistry 32 31683125
2008 Study on synthesis, structure, and DNA-binding of Ni, Zn complexes with 2-phenylquinoline-4-carboylhydrazide. Journal of inorganic biochemistry 30 19026448
2009 Synthesis, characterization, and biological studies of organotin(IV) derivatives with o- or p-hydroxybenzoic acids. Bioinorganic chemistry and applications 27 19390627
2022 Muscle Adaptations to Heavy-Load and Blood Flow Restriction Resistance Training Methods. Frontiers in physiology 26 35185627
2021 Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects. Journal of medical genetics 25 34215651
2012 Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: synthesis, structure and in vitro anticancer activity. European journal of medicinal chemistry 25 23234855
2023 Ruthenium(II)-Dithiocarbazates as Anticancer Agents: Synthesis, Solution Behavior, and Mitochondria-Targeted Apoptotic Cell Death. Chemistry (Weinheim an der Bergstrasse, Germany) 24 36598160
2014 Main group bismuth(III), gallium(III) and diorganotin(IV) complexes derived from bis(2-acetylpyrazine)thiocarbonohydrazone: synthesis, crystal structures and biological evaluation. Dalton transactions (Cambridge, England : 2003) 24 24504550
2020 Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies. Journal of biomolecular structure & dynamics 23 32329409
2017 Structure-activity relationship on DNA binding and anticancer activities of a family of mixed-ligand oxidovanadium(V) hydrazone complexes. Journal of biomolecular structure & dynamics 23 29171343
2013 Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 22 24220672
2022 Solution chemical properties and anticancer potential of 8-hydroxyquinoline hydrazones and their oxidovanadium(IV) complexes. Journal of inorganic biochemistry 20 35940023
2014 Development of synthetic peptide-modified liposomes with LDL receptor targeting capacity and improved anticancer activity. Molecular pharmaceutics 20 24830852
2023 Triazole based Schiff bases and their oxovanadium(IV) complexes: Synthesis, characterization, antibacterial assay, and computational assessments. Heliyon 18 37089299
2017 Biologically Active Cu(II), Co(II), Ni(II) and Zn(II) Complexes of Pyrimidine Derivative Schiff Base: DNA Binding, Antioxidant, Antibacterial and In Vitro Anticancer Studies. Journal of fluorescence 18 28540651
2017 Metal based biologically active compounds: Design, synthesis, DNA binding and antidiabetic activity of 6-methyl-3-formyl chromone derived hydrazones and their metal (II) complexes. Journal of photochemistry and photobiology. B, Biology 18 28892754
2022 Cobalt(III) Complexes for Light-Activated Delivery of Acetylacetonate-BODIPY, Cellular Imaging, and Photodynamic Therapy. Inorganic chemistry 17 35471858
2021 Copper(II) and oxidovanadium(IV) complexes of chromone Schiff bases as potential anticancer agents. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 17 34817681
2017 Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets. The British journal of nutrition 17 28643619
2023 Novel variants in DNAH6 cause male infertility associated with multiple morphological abnormalities of the sperm flagella (MMAF) and ICSI outcomes. Asian journal of andrology 16 37594300
2018 Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis. Annals of the American Thoracic Society 16 29323929
2016 Targeted photocytotoxicity by copper(II) complexes having vitamin B6 and photoactive acridine moieties. European journal of medicinal chemistry 15 27423638
2021 Genetic basis of acephalic spermatozoa syndrome, and intracytoplasmic sperm injection outcomes in infertile men: a systematic scoping review. Journal of assisted reproduction and genetics 14 33452591
2020 Two similar Schiff-base receptor based quinoline derivate: Highly selective fluorescent probe for Zn(II). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 14 32305837
2015 A comparative study of cytotoxicity and interaction with DNA/protein of five transition metal complexes with Schiff base ligands. Journal of photochemistry and photobiology. B, Biology 14 25974907
2014 An investigation on new ruthenium(II) hydrazone complexes as anticancer agents and their interaction with biomolecules. Dalton transactions (Cambridge, England : 2003) 14 24519473
2016 Synthesis, spectral characterization, DNA interaction, radical scavenging and cytotoxicity studies of ruthenium(II) hydrazone complexes. Journal of photochemistry and photobiology. B, Biology 13 26974577
2024 Whole exome sequencing analysis of 167 men with primary infertility. BMC medical genomics 12 39267058
2024 Genetic etiological spectrum of sperm morphological abnormalities. Journal of assisted reproduction and genetics 12 39417902
2024 DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice. eLife 12 39503742
2022 Antiplatelet response to clopidogrel is associated with a haplotype in CYP2C19 gene in Pakistani patients. Scientific reports 11 35418564
2013 DNA binding, DNA cleavage, antioxidant and cytotoxicity studies on ruthenium(II) complexes of benzaldehyde 4-methyl-3-thiosemicarbazones. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 11 23376221
2023 High-Resolution Genomic Profiling of Liver Cancer Links Etiology With Mutation and Epigenetic Signatures. Cellular and molecular gastroenterology and hepatology 10 36965814
2023 A novel frameshift mutation in DNAH6 associated with male infertility and asthenoteratozoospermia. Frontiers in endocrinology 10 37424858
2022 Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole. Pharmaceutics 9 36559078
2017 N,N,N',N'-Tetrabutyl-1,10-phenanthroline-2,9-dicarboxamide as Very Effective Extraction Agent for Trivalent Europium and Americium. Acta chimica Slovenica 9 28862299
2016 Preparations, characterization, and biological features of mononuclear Cu(II) complexes based on hydrazone ligands. Bioorganic & medicinal chemistry letters 9 27634193
2024 Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7. Cells 8 39056782
2022 Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N 4-Allylthiosemicarbazone. Bioinorganic chemistry and applications 8 35662913
2021 Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity. Biomolecules 8 34207929
2017 Exploring the effect of substituent in the hydrazone ligand of a family of μ-oxidodivanadium(v) hydrazone complexes on structure, DNA binding and anticancer activity. Dalton transactions (Cambridge, England : 2003) 8 29138774
2024 Association of novel DNAH11 variants with asthenoteratozoospermia lead to male infertility. Human genomics 7 39256880
2022 Experimental and theoretical studies of new Co(III) complexes of hydrazide derivatives proposed as multi-target inhibitors of SARS-CoV-2. Applied organometallic chemistry 7 35945928
2020 Synthesis, characterization and in vitro antibacterial mechanism study of two Keggin-type polyoxometalates. Journal of inorganic biochemistry 7 32563103
2013 Synthesis, characterization and DNA interaction of new copper(II) complexes of Schiff base-aroylhydrazones bearing naphthalene ring. Journal of photochemistry and photobiology. B, Biology 7 23562627
1999 Posttranscriptional control in the expression of the genes coding for high-light-regulated HL#2 proteins. Planta 7 10550621
2023 Synthesis, spectral, DFT calculation, antimicrobial, antioxidant, DNA/BSA binding and molecular docking studies of bio-pharmacologically active pyrimidine appended Cu(II) and Zn(II) complexes. Journal of biomolecular structure & dynamics 6 37021479
2022 Gallium and indium complexes with isoniazid-derived ligands: Interaction with biomolecules and biological activity against cancer cells and Mycobacterium tuberculosis. Journal of inorganic biochemistry 6 36527994
2020 An Investigation on DNA Binding, Cleavage and Antimicrobial Properties of Mononuclear Co(II), Ni(II) and Cu(II) Complexes Derived from N, O Donor Schiff Bases. Journal of fluorescence 6 32870457
2017 Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone. Oncology letters 6 28599443
2016 Synthesis, spectral characterization of novel Pd(II), Pt(II) π-coordination compounds based on N-allylthioureas. Cytotoxic properties and DNA binding ability. Journal of inorganic biochemistry 6 28086144
2013 Evaluation of DNA-binding, DNA cleavage, antioxidant and cytotoxic activity of mononuclear ruthenium(II) carbonyl complexes of benzaldehyde 4-phenyl-3-thiosemicarbazones. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 6 23845986
2024 A select thiosemicarbazone copper(II) complex induces apoptosis in gastric cancer and targets cancer stem cells reducing pluripotency markers. European journal of medicinal chemistry 5 39489985
2025 Synthesis and Characterization of Novel Hydrazone Complexes: Exploring DNA/BSA Binding and Antimicrobial Potential. ACS omega 4 40028106
2024 In vitro and in vivo antiproliferative activity on lung cancer of two acylhydrazone based zinc(II) complexes. Bioorganic chemistry 4 38705106
2023 A novel water-soluble thiosemicarbazone Schiff base ligand and its complexes as potential anticancer agents and cellular fluorescence imaging. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 4 37129705
2019 Cobalt, nickel and copper complexes with glycinamide: structural insights and magnetic properties. RSC advances 4 35518873
2018 Synthesis, characterization and nucleic acid binding studies of mononuclear copper(II) complexes derived from azo containing O, O donor ligands. Nucleosides, nucleotides & nucleic acids 4 30422758
2015 Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty. PloS one 4 26030606
2025 Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond. Journal of translational medicine 3 40269853
2024 Investigation of antileishmanial, antioxidant activities, CT-DNA interaction and DFT study of novel cobalt(II) complexes derived from mesogenic aromatic amino acids based Schiff base ligands. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 3 39154301
2024 Design of Highly Electrophilic and Stable Metal Nitrido Complexes. Accounts of chemical research 3 39197104
2022 Complexes of 1-(2-R(F, CH3, Cl)-phenyl)-1,4-dihydro-5H-tetrazole-5-thiones with cadmium chloride: Synthesis, molecular, crystal structures and computational investigation approach. Journal of inorganic biochemistry 3 35338940
2022 Presence of Circulatory Autoantibodies Against ROS-Modified Histone H1 Protein in Lymphoma Patients. Frontiers in genetics 3 35692834
2020 A Phase I Study of Everolimus and Bendamustine in Patients With Relapsed/Refractory Lymphoid Hematologic Malignancies. Clinical lymphoma, myeloma & leukemia 3 32171691
2018 [Synchronous lymphoma and carcinoma-clinical analyses of 17 patients]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 3 29779320
2017 Copper(II) complexes of N3O tripodal ligands appended with pyrene and polyamine groups: Anti-proliferative and nuclease activities. Journal of inorganic biochemistry 3 29222969
2023 Biochemical Resistivity against Free Radicals and Microbes: Cooperative Action of Zn(II)/Imidazole in Phosphoesterase-Mediated Cell Death. ACS applied bio materials 2 37565455
2022 Zn(II) coordination polymers: therapeutic activity and nursing application values against coronary heart disease. Designed monomers and polymers 2 35711619
2020 Novel triorganotin complexes based on phosphonic acid ligands: Syntheses, structures and in vitro cytostatic activity. Journal of inorganic biochemistry 2 32070916
2019 Tin thiocarbonohydrazone complexes: synthesis, crystal structures and biological evaluation. Toxicology research 2 32206301
1997 Copper(I)-Purine-Phosphine Complexes. Syntheses and Molecular Structures of [Cu(2)(&mgr;-HL(1))(2)(&mgr;-dppm)(eta(1)-dppm)(2)] and {[Cu(3)(&mgr;(3)-Cl)(2)(&mgr;-dppm)(3)][Cu(HL(2))(2)]} (H(2)L(1) = 8-Mercaptotheophylline and H(2)L(2) = 8-Ethyl-3-methylxanthine). Inorganic chemistry 2 11669672
2025 Two multifunctional zero-dimensional Gd(III) complexes: magnetocaloric effect and anticancer mechanisms for lung cancer. Journal of inorganic biochemistry 1 39874637
2024 Copper(II) coordination compounds based on bis-hydrazones of 2,6-diacetylpyridine: synthesis, structure, and cytotoxic activity. Dalton transactions (Cambridge, England : 2003) 1 38261350
2024 Molecular characterization of DNAH6 and ATPase6 (Mitochondrial DNA) genes in asthenozoospermia patients in the northern region of India. BMC urology 1 39192248
2023 Synthesis and Characterization of New Mixed-Ligand Complexes; Density Functional Theory, Hirshfeld, and In Silico Assays Strengthen the Bioactivity Performed In Vitro. ACS omega 1 36743043
2022 Fabricate, advancement, molecular docking and DNA reactivity of preferred divalent metal(II) complexes attributing (E)-N'-((6-hydroxybenzo[d]oxazol-5-yl) methylene)isonicotinohydrazide. Nucleosides, nucleotides & nucleic acids 1 35635500
2022 Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes. Molecules (Basel, Switzerland) 1 36432074
2021 HLA-G 3'UTR haplotype frequencies in highland and lowland South Native American populations. Human immunology 1 34563386
2019 Coexistence of Serum Monoclonal Gammopathy of Uncertain Significance and Hodgkin Lymphoma. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion 1 32425396
2025 Anti-tumor and cellular mechanisms of HfIVtetra-(8-hydroxyquinolinato) complexes. Journal of inorganic biochemistry 0 40373563
2025 Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads. Comparative biochemistry and physiology. Part D, Genomics & proteomics 0 40694934
2025 The essential role of cytoskeleton and ciliary abnormalities in the development of congenital pulmonary airway malformations. Pediatric surgery international 0 41264116
2025 Zinc complex with quinoline-based thiazolyl-hydrazone targeting DNA replication in cancer cells. Scientific reports 0 41274949
2024 Heterocyclic (pyrazine)carboxamide Ru(ii) complexes: structural, experimental and theoretical studies of interactions with biomolecules and cytotoxicity. RSC advances 0 38567259