Affinage

DMP1

Cyclin-D-binding Myb-like transcription factor 1 · UniProt Q9Y222

Length
760 aa
Mass
84.5 kDa
Annotated
2026-06-09
100 papers in source corpus 43 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The DMP1 locus encodes two functionally distinct proteins. The first is a secreted bone/dentin extracellular matrix protein that, after proteolytic activation, governs skeletal mineralization, osteocyte maturation, and systemic phosphate homeostasis (PMID:17033621, PMID:17033625, PMID:20663874, PMID:20734454). Full-length DMP1 is an inactive precursor that is cleaved at Asp213 by furin into a 37-kDa N-terminal and a 57-kDa C-terminal fragment; this processing is essential, as cleavage-resistant D213A-DMP1 fails to rescue skeletal, dentin, cementum, and alveolar bone defects in Dmp1-null mice (PMID:18728349, PMID:20663874, PMID:21297011). The 57-kDa C-terminal fragment is the functional moiety: transgenic expression of this fragment alone fully rescues growth plate, osteomalacia, osteocyte/lacunocanalicular, FGF23, and hypophosphatemia phenotypes of Dmp1-null mice (PMID:20734454). The fragment is phosphorylated by Fam20C in the Golgi and secreted into the pericanalicular bone matrix, and phosphorylation is required for its capacity to organize collagen mineralization and promote hydroxyapatite formation, whereas the proteoglycan form (DMP1-PG) inhibits mineralization (PMID:21736373, PMID:20200415, PMID:27614627). In osteocytes, DMP1 represses FGF23 transcription—loss of DMP1 elevates osteocyte FGF23, causing renal phosphate wasting and rickets/osteomalacia, and human loss-of-function DMP1 mutations cause autosomal recessive hypophosphatemic rickets; FGF23 is causally required downstream of DMP1 loss for the hypophosphatemia phenotype, and DMP1 and PHEX converge on FGFR signaling to control FGF23 (PMID:17033621, PMID:17033625, PMID:18559986, PMID:21507898). Mechanistically, secreted DMP1 acts as a ligand: it signals through αvβ3 integrin to activate FAK/ERK/JNK MAPK cascades, downregulates FGF23 via FAK-MEK/ERK signaling, and through endocytosis raises cytosolic calcium to activate p38 MAPK and Runx2, driving osteoblast/odontoblast differentiation, with DSPP acting as a downstream dentinogenic effector (PMID:21642437, PMID:20841352, PMID:23349460, PMID:24991406). The second protein is the cyclin D-binding myb-like transcription factor DMTF1 (DMP1α), which binds the CCCG(G/T)ATGT consensus and acts as a haplo-insufficient tumor suppressor linking oncogenic signaling to the ARF–p53 axis (PMID:8887674, PMID:10898794, PMID:11711428). Oncogenic Ras-Raf-MEK-ERK (via Fos/Jun), HER2/PI3K-Akt-NF-κB, and cyclin D1 activate DMTF1, which directly transactivates the ARF promoter and physically binds and stabilizes p53 by antagonizing Mdm2-mediated ubiquitination, while NF-κB p65 and E2F proteins repress it (PMID:15601844, PMID:16878159, PMID:21062982, PMID:22331460, PMID:23938323). An alternative splice isoform DMP1β lacks tumor-suppressive function and instead promotes mammary tumorigenesis (PMID:25537728).

Mechanistic history

Synthesis pass · year-by-year structured walk · 29 steps
  1. 1996 High

    Established the existence of a cyclin D-binding myb-like transcription factor at the DMP1 locus, defining its DNA-binding specificity and direct physical link to cell-cycle machinery.

    Evidence Yeast two-hybrid, in vitro binding, Sf9 co-expression, kinase and reporter assays

    PMID:8887674

    Open questions at the time
    • No in vivo transcriptional targets identified yet
    • Biological consequence of CDK4/6 phosphorylation unknown
  2. 1998 High

    Defined how DMTF1 transactivates targets, showing domain requirements, synergy with c-Myb, and CDK-independent antagonism by cyclin D.

    Evidence Promoter reporter, EMSA, domain mutants, endogenous binding in myeloid nuclear extracts

    PMID:9786929

    Open questions at the time
    • Functional role of CD13/APN target in normal physiology unclear
    • Mechanism of cyclin D antagonism not structurally resolved
  3. 2000 High

    Placed DMTF1 upstream of the ARF–p53 tumor suppressor pathway, showing its loss permits oncogene-driven transformation.

    Evidence Dmp1 knockout MEFs, Ras transformation, senescence and tumor assays

    PMID:10898794

    Open questions at the time
    • Whether ARF induction is direct not yet shown
    • Other DMTF1 targets in tumor suppression unknown
  4. 2001 High

    Demonstrated DMTF1 is haplo-insufficient in vivo, functionally substituting for ARF/p53 loss during lymphomagenesis.

    Evidence Dmp1+/- and null mice, E-mu-Myc crosses, molecular ARF/p53 status

    PMID:11711428

    Open questions at the time
    • Tissue specificity of haplo-insufficiency not mapped
    • Upstream activating signals not yet defined
  5. 2005 High

    Identified DMTF1 as the critical intermediary linking Ras-Raf-MEK-ERK oncogenic signaling to ARF transcription, with Jun proteins as the connecting element.

    Evidence Promoter reporter, ChIP, MEK inhibitors, siRNA, Dmp1-null MEFs

    PMID:15601844

    Open questions at the time
    • Direct ERK target site on Dmp1 promoter not fully resolved
    • Relative contribution of each Jun factor unclear
  6. 2007 Medium

    Mapped the transcriptional regulators of DMTF1, showing E2F and NF-kB p65 repress it, integrating cell-cycle and stress signals into the Arf pathway.

    Evidence ChIP, reporter assays, IHC, p65 knockdown in null cells

    PMID:16878159 PMID:17546045

    Open questions at the time
    • Combinatorial control by repressors and activators not modeled
    • Single-lab observations
  7. 2007 High

    Extended DMTF1 tumor suppression to human lung cancer, showing LOH mutually exclusive with ARF/p53 mutation and K-ras epistasis in vivo.

    Evidence Human tumor LOH analysis, K-ras(LA) mouse crosses, survival and p53 status

    PMID:17936562

    Open questions at the time
    • Mechanism of allelic loss not defined
    • Therapeutic implications untested
  8. 2010 Medium

    Defined HER2 and cyclin D1 as upstream activators of DMTF1, mechanistically widening the oncogenic-signal-to-ARF circuit.

    Evidence Reporter, ChIP, MMTV-neu and MMTV-cyclin D1 crosses with Dmp1-null mice

    PMID:21062982 PMID:23938323

    Open questions at the time
    • Crosstalk between Ras and HER2 inputs not integrated
    • cyclin D1 data partly dependent on later interaction work
  9. 2012 High

    Revealed an Arf-independent arm of DMTF1 tumor suppression: direct physical interaction with p53 that blocks Mdm2 ubiquitination and stabilizes p53.

    Evidence Reciprocal Co-IP, ubiquitination assay, domain mapping, nuclear localization, p53-/-;Arf-/- cells

    PMID:22331460

    Open questions at the time
    • Structural basis of the DMTF1–p53 interface unresolved
    • Relative weight of Arf-dependent vs -independent arms in vivo unclear
  10. 2012 Medium

    Identified direct DMTF1 transcriptional targets beyond ARF (amphiregulin, thrombospondin-1, JunB, Egr1), broadening its regulatory output.

    Evidence Microarray of null lungs, ChIP, reporter assays, RT-PCR

    PMID:19816943

    Open questions at the time
    • Functional significance of each target in tumor suppression untested
    • Single-lab dataset
  11. 2015 High

    Showed the locus also encodes an oncogenic splice isoform DMP1β with opposing function, complicating the single-tumor-suppressor model.

    Evidence MMTV-DMP1β transgenic mice, proliferation assays, RNA-seq

    PMID:25537728

    Open questions at the time
    • Mechanism by which DMP1β promotes tumorigenesis not defined
    • Regulation of isoform choice unknown
  12. 2003 Medium

    Established that the matrix-protein DMP1 is mechanosensitively induced specifically in osteocytes, hinting at a mechanotransduction role.

    Evidence In situ hybridization, ICC, quantitative mRNA in tooth movement model

    PMID:12733719

    Open questions at the time
    • Signaling pathway from load to Dmp1 induction unknown
    • Downstream consequences of induction not measured here
  13. 2004 High

    Demonstrated DMP1 is essential for postnatal chondrogenesis and skeletal development through knockout phenotyping.

    Evidence Knockout mice, histology, BrdU, TUNEL, micro-CT

    PMID:15590631

    Open questions at the time
    • Molecular mechanism in cartilage not defined here
    • Cell-autonomous vs systemic contributions unresolved
  14. 2006 High

    Defined the bone-renal axis: DMP1 loss impairs osteocyte maturation and elevates FGF23, causing hypophosphatemic rickets, with human mutations validating the pathway.

    Evidence Knockout phenotyping, FGF23 measurement, human mutational analysis

    PMID:17033621 PMID:17033625

    Open questions at the time
    • Direct molecular link between DMP1 and FGF23 transcription not yet shown here
    • How osteocyte maturation controls FGF23 unclear
  15. 2006 High

    Showed DMP1 is required in both early and late odontoblasts for dentinogenesis using stage-specific transgenic rescue.

    Evidence Col1a1- and Dspp-promoter transgenic rescue in null mice, fluorochrome labeling, confocal

    PMID:17196192

    Open questions at the time
    • Stage-specific molecular targets not identified
    • Mechanism of partial late rescue unexplained
  16. 2008 Medium

    Identified furin (not PHEX) as the protease processing DMP1 into N- and C-terminal fragments, defining the activation event.

    Evidence Multiple cell lines, furin inhibitor, PHEX co-expression, Western blot

    PMID:18728349

    Open questions at the time
    • No direct in vitro furin cleavage reconstitution shown
    • Cleavage site not biochemically mapped here
  17. 2008 High

    Established FGF23 as causally required downstream of DMP1 loss for hypophosphatemia, via compound knockout epistasis.

    Evidence Dmp1-/-/Fgf23-/- compound mice, serum biochemistry, histomorphometry

    PMID:18559986

    Open questions at the time
    • Direct transcriptional control of FGF23 by DMP1 not shown here
    • Cell type mediating control not isolated
  18. 2008 Medium

    Showed the M1V human mutation disrupts secretory trafficking and that vitamin D upregulates DMP1, linking mutations to cellular dysfunction.

    Evidence Immunofluorescence, Western blot, mutant constructs, vitamin D treatment of UMR-106

    PMID:19007919

    Open questions at the time
    • Quantitative impact on secretion not measured
    • Single-lab finding
  19. 2010 Medium

    Defined the fragment biology: distinct spatial distributions of N- and C-terminal fragments and the proteoglycan form across mineralizing tissues.

    Evidence Fragment-specific immunofluorescence, FRET, biochemical fractionation

    PMID:18854597

    Open questions at the time
    • Functional consequence of distinct distributions not tested here
    • Single-lab data
  20. 2010 High

    Proved that Asp213 cleavage is the obligatory activation step for DMP1 function in osteogenesis using cleavage-resistant rescue.

    Evidence D213A-DMP1 transgenic rescue on null background, Western blot, radiology

    PMID:20663874 PMID:21297011

    Open questions at the time
    • Whether N-terminal fragment has independent function not resolved here
    • Kinetics of in vivo cleavage unknown
  21. 2010 High

    Identified the cell-surface signaling mechanism: DMP1 acts as an αvβ3 integrin ligand activating FAK/ERK/JNK and, via endocytosis-driven calcium flux, p38/Runx2 to drive differentiation.

    Evidence Recombinant DMP1 treatment, FAK staining, phospho-Western, calcium imaging, integrin antibody blockade, inhibitors

    PMID:20841352 PMID:21642437

    Open questions at the time
    • Receptor responsible for endocytic calcium response distinct from integrin not defined
    • In vivo relevance of signaling not confirmed
  22. 2011 High

    Pinpointed the 57-kDa C-terminal fragment as the functional unit sufficient to rescue all skeletal/phosphate phenotypes of DMP1 loss.

    Evidence Transgenic rescue with 57-kDa fragment vs full-length, micro-CT, histomorphometry, FGF23 ELISA

    PMID:20734454

    Open questions at the time
    • Independent role of N-terminal fragment not addressed
    • Molecular target of the C-terminal fragment unknown
  23. 2011 High

    Showed PHEX and DMP1 converge on FGFR signaling to regulate FGF23, unifying two hypophosphatemic-rickets genes in one pathway.

    Evidence Hyp/Dmp1-/- compound mice, microarray, SU5402 FGFR inhibition of stromal cells

    PMID:21507898

    Open questions at the time
    • Molecular intersection point of PHEX and DMP1 not defined
    • Direct FGFR ligand in this context unclear
  24. 2011 High

    Demonstrated phosphorylation governs DMP1's mineralization activity, with fragments promoting and the proteoglycan form inhibiting hydroxyapatite formation.

    Evidence In vitro mineralization assays, FTIR, phosphorylated vs dephosphorylated comparisons

    PMID:20200415 PMID:21736373

    Open questions at the time
    • Identity of physiological kinase not addressed here
    • Structural basis of HA nucleation incompletely resolved
  25. 2013 High

    Placed DSPP and KLF4 in the dentinogenic pathway, with DSPP as a downstream effector and KLF4 as an upstream activator of DMP1.

    Evidence Dmp1-KO/DSPP-Tg rescue, Dspp-KO mice, ChIP, EMSA, reporter, knockdown/rescue

    PMID:23349460 PMID:23558921

    Open questions at the time
    • How DMP1 induces DSPP transcription mechanistically unclear
    • KLF4 data single-lab Medium confidence
  26. 2014 Medium

    Showed exogenous DMP1 directly suppresses FGF23 in osteocyte-like cells through FAK-MEK/ERK signaling, providing the local molecular mechanism for the bone-renal axis.

    Evidence Recombinant DMP1 treatment, FGF23 ELISA, FAK/MEK/PI3K/ROCK inhibitors, phospho-Westerns

    PMID:24991406

    Open questions at the time
    • Transcription factor mediating FGF23 repression not identified here
    • Single-lab finding
  27. 2016 Medium

    Identified Fam20C as the Golgi kinase phosphorylating the C-terminal fragment, and showed glycosylation at Ser89 is required for condylar chondrogenesis via TGF-β signaling.

    Evidence Immunoelectron microscopy/colocalization for Fam20C; S89G knock-in mice, histology, TGF-β analysis

    PMID:27614627 PMID:28759313

    Open questions at the time
    • No direct in vitro Fam20C kinase assay on DMP1 described
    • Single-lab knock-in study
  28. 2019 Medium

    Defined a GRP78-receptor-mediated endocytic trafficking route to the nucleus and showed DMP1 supplementation is therapeutic in CKD by attenuating NFAT-driven FGF23 and protecting osteocytes.

    Evidence TIRF/confocal/Co-IP of DMP1-GRP78; Col4a3-/- CKD model with DMP1 supplementation, NFAT analysis, echocardiography

    PMID:31044094 PMID:31572220

    Open questions at the time
    • Whether GRP78 and αvβ3 act in the same or parallel pathways unclear
    • Nuclear function of internalized DMP1 not defined
    • Single-lab studies
  29. 2024 Medium

    Revealed an unanticipated role for a Dmp1-expressing astrocyte subset in maintaining blood-brain barrier integrity via MFN2-dependent mitochondrial transfer to endothelium.

    Evidence Dmp1-Cre conditional Mfn2 knockout, BBB permeability assays, mitochondrial transfer imaging

    PMID:38941455

    Open questions at the time
    • Whether DMP1 protein itself functions in astrocytes or is merely a Cre driver unclear
    • Mechanism of mitochondrial transfer not molecularly resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the two products of the DMP1 locus—the secreted matrix protein and the nuclear DMTF1 transcription factor—are independently produced, regulated, and whether they ever functionally intersect remains unresolved.
  • Splicing/promoter logic distinguishing the two products not defined in the corpus
  • Whether nuclear matrix-DMP1 (idx 38) has a transcriptional function is uncharacterized
  • Structural basis of DMTF1–p53 and DMTF1–cyclin D interfaces not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0003677 DNA binding 4 GO:0048018 receptor ligand activity 4 GO:0005198 structural molecule activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 4 GO:0031012 extracellular matrix 4 GO:0005576 extracellular region 2 GO:0005794 Golgi apparatus 2 GO:0005886 plasma membrane 2 GO:0005768 endosome 1
Pathway
R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1266738 Developmental Biology 4 R-HSA-1640170 Cell Cycle 4 R-HSA-1430728 Metabolism 3 R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3
Partners
CCND1CDK4CDK6FAM20CHSPA5ITGAVMDM2TP53

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 DMP1 (cyclin D-interacting myb-like protein 1; DMTF1) was identified as a novel transcription factor that binds specifically to the nonamer DNA consensus sequence CCCG(G/T)ATGT to activate transcription. It binds D-type cyclins (D1, D2, D3) directly in vitro and when coexpressed in Sf9 insect cells, and can be phosphorylated by cyclin D-dependent kinases CDK4/CDK6 in both settings. Yeast two-hybrid screen, in vitro binding assay, Sf9 co-expression, kinase assay, DNA binding/reporter assays Molecular and cellular biology High 8887674
1998 DMP1 (DMTF1) transcriptional activation of target gene CD13/aminopeptidase N requires both its intact DNA-binding and transactivation domains, and is antagonized by D-type cyclins in a CDK-independent manner. DMP1 binds a GGA-core-containing Ets site (Ets C) in the CD13/APN promoter and synergizes with c-Myb to activate expression. Endogenous DMP1 was confirmed to bind this element in nuclear extracts from KG1a myeloid cells. Promoter reporter assay, EMSA (electrophoretic mobility shift assay), deletion/mutation analysis, co-transfection with cyclin constructs The Journal of biological chemistry High 9786929
2000 DMP1 (DMTF1) induces ARF tumor suppressor gene expression in mouse fibroblasts, leading to p53-dependent cell cycle arrest. DMP1-null MEFs bypass senescence, retain low p19ARF/Mdm2/p53 levels, and can be transformed by oncogenic Ha-Ras alone, phenocopying ARF-null or p53-null MEFs. Loss of DMP1 function compromises but does not eliminate ARF function. Gene targeting/knockout mouse, MEF culture, passage assays, oncogenic Ras transformation, karyotypic analysis, tumor induction experiments Genes & development High 10898794
2001 Dmp1 (DMTF1) is haplo-insufficient for tumor suppression; Dmp1+/- mice develop spontaneous tumors and show accelerated E-mu-Myc-induced B-cell lymphoma with reduced frequency of p53 mutations or ARF deletion, demonstrating that Dmp1 loss functionally substitutes for ARF/p53 pathway inactivation in vivo. Dmp1 heterozygous and null mouse models, E-mu-Myc lymphoma crosses, tumor latency analysis, molecular analysis of ARF/p53 status in tumors Genes & development High 11711428
2003 DMP1 mRNA expression in osteocytes (but not osteoblasts) increases up to 3.7-fold within 6 hours of mechanical loading in the mouse tooth movement model, demonstrating that DMP1 is mechanosensitively regulated in osteocytes. In situ hybridization, immunocytochemistry, quantitative mRNA analysis in mouse tooth movement mechanical loading model Journal of bone and mineral research Medium 12733719
2004 Dmp1-deficient mice develop severe postnatal chondrogenesis defects including expanded proliferating and hypertrophic zones, delayed secondary ossification, increased cell proliferation, reduced apoptosis in the hypertrophic zone, and impaired blood vessel invasion in epiphyses, demonstrating DMP1 is essential for normal postnatal chondrogenesis. Gene-targeted knockout mice, histology, immunohistochemistry, BrdU proliferation assay, TUNEL apoptosis assay, micro-CT The Journal of biological chemistry High 15590631
2005 The Dmp1 (DMTF1) promoter is activated by oncogenic Ha-Ras(V12) through Raf-MEK-ERK signaling; induction of p19Arf and p21Cip1 by oncogenic Raf is compromised in Dmp1-null cells; a Ras-responsive element was mapped to the 5' leader where Fos/Jun proteins bind. Dmp1 promoter activation by Ras(V12) requires Jun proteins (c-Jun, JunB). Endogenous Dmp1 binds the Dmp1/Ets site on the Arf promoter upon oncogenic Raf activation, placing Dmp1 as the critical intermediary linking Ras-Raf oncogenic signaling to Arf-p53 activation. Primary cell culture, promoter reporter assays, ChIP, siRNA knockdown, Dmp1-null MEFs, MEK inhibitors Molecular and cellular biology High 15601844
2005 DMP1 depletion in vivo results in decreased mineral-to-matrix ratio and increased crystal size/perfection in bone, indicating DMP1 has both direct roles in mineral formation and crystal growth, and indirect roles via regulation of Ca×P concentrations and matrix turnover. FTIR imaging spectroscopy (FTIRI), histology, micro-CT, serum calcium/phosphate measurement in dmp1 null mice Journal of bone and mineral research Medium 16294270
2006 Loss of DMP1 in mice results in defective osteocyte maturation and increased FGF23 expression in osteocytes, leading to renal phosphate-wasting (hypophosphatemia) and pathological bone mineralization defects (rickets/osteomalacia). Human DMP1 mutations (start codon Met1Val and 7-bp deletion in C-terminus) cause autosomal recessive hypophosphatemic rickets with elevated FGF23, establishing a bone-renal axis whereby DMP1 in osteocytes regulates FGF23 and phosphate homeostasis. Dmp1 knockout mouse phenotyping, immunohistochemistry, FGF23 measurement, mutational analysis in human patients, serum biochemistry Nature genetics High 17033621 17033625
2006 Re-expression of DMP1 under the Col1a1 promoter in early odontoblasts fully rescued mineralization defects, dentinal tubule abnormalities, and third molar development in Dmp1-null mice; re-expression in mature odontoblasts (Dspp promoter) gave only partial rescue. This demonstrates DMP1 is required in both early and late odontoblasts for normal dentinogenesis and odontoblast differentiation. Transgenic rescue in Dmp1-null mice, fluorochrome labeling of dentin, histology, confocal microscopy Developmental biology High 17196192
2007 Dmp1 (DMTF1) expression is repressed by E2F proteins upon mitogenic signaling (S to G2/M phase); subsets of E2Fs 1-4 bind the Dmp1 promoter and inhibit its activity. Dmp1 and Ki67 are expressed in mutually exclusive fashion in tissues, consistent with Dmp1 being a marker of post-mitotic, differentiated cells whose expression is E2F-dependent. Immunohistochemistry, double-staining (Dmp1/Ki67), ChIP, promoter reporter assay, E2F dominant-positive cells Oncogene Medium 16878159
2007 ASARM peptides derived from DMP1 and MEPE are potent inhibitors of mineralization (minhibins). In HYP BMSCs, massive degradation of MEPE and DMP1 occurs. ASARM peptides directly cause mineralization defects: WT BMSCs fail to mineralize when treated with ASARM peptide, and HYP BMSCs mineralize normally when treated with anti-ASARM antibodies or SPR4 peptide. SPR4 peptide binds ASARM peptide (confirmed by SPR and 2D NMR), reversing the mineralization defect. BMSC coculture mineralization assays, surface plasmon resonance (SPR), 2D 1H/15N NMR, Western blot, anti-ASARM antibody neutralization Endocrinology High 18162525
2007 Dmp1 (DMTF1) loss of heterozygosity occurs in ~40% of human non-small cell lung carcinomas in mutually exclusive fashion with ARF/p53 mutations; Dmp1 deletion in K-ras(LA) mice shortened survival (~15 weeks) and reduced p53 mutation frequency in lung tumors, establishing DMP1 as a pivotal tumor suppressor linking K-ras oncogenic signaling to Arf/p53 in lung cancer. LOH analysis in human tumors, K-ras(LA) mouse crosses with Dmp1+/- and Dmp1-/-, survival analysis, molecular analysis of p53 mutation status Cancer cell High 17936562
2007 The NF-κB subunit p65 represses the Dmp1 (DMTF1) promoter in response to anthracyclins/UV-C treatment; p65 binds to the Dmp1 promoter, reducing Dmp1 mRNA and protein levels, which in turn decreases Arf expression. This identifies NF-κB as a repressor of the Dmp1-Arf pathway under genotoxic stress. Promoter reporter assay, ChIP, p65 knockdown, Dmp1-/- cells, Arf promoter analysis Oncogene Medium 17546045
2008 FGF23 is causally required downstream of DMP1 loss for the hypophosphatemia and diffuse osteomalacia phenotype in Dmp1-null mice: Dmp1-/-/Fgf23-/- compound mice lack detectable FGF23, and their serum phosphate/1,25(OH)2D levels are identical to Fgf23-/- mice, with transformation of the diffuse rickets phenotype into the focal osteomalacia of Fgf23-/- mice. Compound knockout mouse generation, serum biochemistry (FGF23, phosphate, 1,25(OH)2D), bone histomorphometry, FGF23-eGFP reporter American journal of physiology. Endocrinology and metabolism High 18559986
2008 DMP1 is proteolytically cleaved into a 37-kDa N-terminal and a 57-kDa C-terminal fragment in all cell lines tested (293EBNA, CHO, 2T3). This cleavage is blocked by a furin protease inhibitor (decanoyl-Arg-Val-Lys-Arg-chloromethyl ketone) in a dose-dependent manner. Coexpression of PHEX had no apparent effect on DMP1 cleavage in 293EBNA cells, indicating PHEX is not the protease responsible for DMP1 processing. Cell transfection/expression in multiple cell lines, Western blot, furin inhibitor treatment, PHEX co-expression Cells, tissues, organs Medium 18728349
2008 DMP1 M1V mutation prevents sorting to the trans-Golgi network and secretory pathway (protein fills entire cytoplasm), while the 1484-1490 deletion mutant localizes to the TGN and is secreted similarly to wild-type DMP1. The last 18 native C-terminal residues of DMP1 are not critical for cellular trafficking, but the 33 non-native residues from the deletion compromise processing. DMP1 mRNA and protein are upregulated ~12-fold by 1,25(OH)2D in UMR-106 cells. Immunofluorescence/confocal microscopy, Western blot, expression constructs in cells, vitamin D treatment of UMR-106 cells Bone Medium 19007919
2009 MMP-2 cleaves DMP1 (both recombinant and native forms in dentin matrix) to produce two major peptides; the C-terminal peptide promotes differentiation of dental pulp stem/progenitor cells to an odontoblast phenotype in vitro, and induces rapid formation of a homogeneous dentin bridge with DMP1/DSP-expressing polarized cells in an in vivo rat injured pulp model. In vitro MMP-2 cleavage of recombinant DMP1 and dentin matrix, BMSC/dental pulp stem cell differentiation assays, in vivo rat pulp injury model, immunohistochemistry European cells & materials Medium 19908197
2010 DMP1 signals via αvβ3 integrin at the cell surface: extracellular DMP1 triggers focal adhesion formation, phosphorylation of focal adhesion kinase, and downstream activation of ERK and JNK (MAPK pathways) in human mesenchymal stem cells and osteoblast-like cells. Activated phospho-JNK translocates to the nucleus and upregulates c-Jun-mediated transcription. These effects are blocked by anti-αvβ3 integrin antibody. Cell treatment with recombinant DMP1, focal adhesion staining, Western blot for pFAK/pERK/pJNK, nuclear fractionation, anti-integrin antibody blockade, reporter assay The Journal of biological chemistry High 21642437
2010 DMP1-mediated endocytosis triggers a rise in cytosolic calcium in preosteoblasts, which activates store-operated calcium release and stress-induced p38 MAPK, leading to p38 nuclear translocation and phosphorylation of Runx2, thereby promoting osteoblast differentiation. Chelation of intracellular calcium or pharmacological inhibition of p38 suppressed differentiation. DMP1 treatment of preosteoblasts, calcium imaging, p38 MAPK inhibitors, dominant negative plasmid, Western blot for Runx2 The Journal of biological chemistry Medium 20841352
2010 Full-length DMP1 is an inactive precursor; its proteolytic processing (cleavage at Asp213) is an activation step essential for biological function in osteogenesis. Transgenic expression of cleavage-resistant D213A-DMP1 in Dmp1-KO mice fails to rescue skeletal phenotypes, while normal DMP1 fully rescues them. Transgenic mice expressing D213A mutant DMP1 on Dmp1-KO background, Western blot, radiological and morphological phenotyping, crossbreeding with normal DMP1 transgene as control The Journal of biological chemistry High 20663874
2010 The 37-kDa N-terminal and 57-kDa C-terminal DMP1 fragments have distinct spatial distributions: in rat molar, N-terminal is in predentin while C-terminal is in mineralized dentin; in growth plate, N-terminal is in proliferating/hypertrophic zones, C-terminal in ossification zone. Predentin is rich in DMP1-PG (proteoglycan form); mineralized dentin primarily contains C-terminal fragment. Both fragments colocalize in odontoblasts/predentin (confirmed by FRET). Immunofluorescence with fragment-specific antibodies, confocal microscopy, FRET analysis, Western blot of bovine tooth fractions The journal of histochemistry and cytochemistry Medium 18854597
2010 The HER2/neu oncogene activates the Dmp1 (DMTF1) promoter through the PI3K-Akt-NF-κB pathway (p65 and p52 subunits bind the Dmp1 promoter), which in turn stimulates Arf transcription. This pathway is active in premalignant mammary lesions; mammary tumorigenesis is significantly accelerated in Dmp1+/- and Dmp1-/- mice crossed with MMTV-neu. Promoter reporter assay, ChIP (p65/p52 binding to Dmp1 promoter, Dmp1 binding to Arf promoter), MMTV-neu mouse crosses with Dmp1-null mice, IHC of premalignant lesions Cancer research High 21062982
2011 The 57-kDa C-terminal fragment of DMP1 is the functional domain responsible for osteocyte maturation, phosphate homeostasis, and FGF23 regulation: transgenic expression of just the 57-kDa fragment (under Col1 3.6kb promoter) fully rescues growth plate defects, osteomalacia, osteocyte maturation/lacunocanalicular system defects, elevated FGF23, and hypophosphatemia in Dmp1-null mice—as well as full-length DMP1. Transgenic rescue in Dmp1-null mice (57-kDa fragment vs. full-length), micro-CT, histomorphometry, FGF23 ELISA, serum phosphate, osteocyte morphology Journal of bone and mineral research High 20734454
2011 PHEX and DMP1 regulate FGF23 expression through a common pathway involving FGFR signaling in osteocytes: compound Hyp/Dmp1-/- mice show non-additive FGF23 elevations; FGFR pathway gene expression is similarly activated in all mutant groups; inhibiting FGFR signaling with SU5402 prevents increased Fgf23 mRNA in both Hyp- and Dmp1-/--derived bone marrow stromal cells. Compound knockout mice (Hyp/Dmp1-/-), serum FGF23/phosphate measurements, bone mineral density, microarray gene expression, FGFR inhibitor (SU5402) treatment of bone marrow stromal cells FASEB journal High 21507898
2011 DMP1 proteolytic processing at Asp213 is also essential for normal dentin, cementum, and jaw bone formation: cleavage-resistant D213A-DMP1 is not cleaved in dentin and fails to rescue dentin, cementum, and alveolar bone defects in Dmp1-KO mice. Transgenic mice with D213A-DMP1 on Dmp1-KO background, histology, Western blot, radiological analysis Journal of dental research Medium 21297011
2011 Phosphorylated DMP1 facilitates organized mineralization of collagen fibrils and induces formation of organized mineral bundles even without collagen in vitro; phosphorylation profoundly affects its mineralization-regulating activity. Full-length DMP1 and its fragments (37K, 57K, DMP1-PG) have distinct effects: 37K and 57K promote hydroxyapatite formation while DMP1-PG inhibits it; full-length DMP1 undergoes slight conformational change upon HA binding while fragments do not. In vitro calcium phosphate mineralization assays, FTIR spectroscopy, gelatin-gel system, phosphorylated vs. dephosphorylated protein comparison Biomacromolecules / Journal of dental research High 20200415 21736373
2012 Dmp1 (DMTF1) physically interacts with p53 directly via the carboxyl-terminus of p53 and the DNA-binding domain of Dmp1 in mammalian cells. Dmp1 expression antagonizes Mdm2-mediated ubiquitination of p53 and promotes nuclear localization of p53. This Arf-independent mechanism synergistically activates p53 target genes and enhances genotoxic responses. Co-immunoprecipitation in mammalian cells, p53 ubiquitination assay, nuclear localization assays, gene expression in p53-/-;Arf-/- cells, domain mapping Cancer research High 22331460
2012 Dmp1 (DMTF1) directly activates transcription of amphiregulin, thrombospondin-1, JunB, and Egr1: Dmp1 binds genomic loci of these targets (confirmed by ChIP), and their expression is significantly altered in Dmp1-null and Dmp1-heterozygous mouse lungs. Microarray of Dmp1-null vs. wild-type lungs, ChIP for Dmp1 binding to target loci, transient transfection reporter assays, RT-PCR validation International journal of cancer Medium 19816943
2012 Cyclin D1 bound to Dmp1 (DMTF1) activates both Arf and Ink4a promoters, inducing apoptosis or G2/M delay in normal cells. This cyclin D1-induced Ink4a/Arf expression is fully dependent on Dmp1 (absent in Dmp1-deficient or DMP1-depleted cells), revealing that cyclin D1 anti-tumor activity is mediated through Dmp1. MMTV-cyclin D1 crosses with Dmp1-null mice, promoter reporter assays, Arf/Ink4a expression analyses, apoptosis assays The American journal of pathology Medium 23938323
2013 DSPP is a downstream effector of DMP1 in dentinogenesis: DMP1 and its 57-kDa C-terminal fragment significantly upregulate the Dspp promoter in vitro; endogenous DSPP is markedly reduced in Dmp1-KO mice; transgenic DSPP expression rescues tooth and alveolar bone defects of Dmp1-KO mice; DMP1 expression is unchanged in Dspp-KO mice. Dmp1-KO/DSPP-Tg transgenic rescue mice, Dspp-KO mice, in vitro promoter reporter assay, Western blot, histology The Journal of biological chemistry High 23349460
2013 KLF4 directly binds the Dmp1 promoter and transactivates its expression, promoting odontoblastic differentiation; KLF4 overexpression upregulates Dmp1, Dspp, and Alp, while KLF4 knockdown reduces them. Forced expression of Dmp1 in KLF4 knockdown cells significantly recovers odontoblastic differentiation, placing Dmp1 downstream of Klf4. ChIP, EMSA, dual luciferase promoter assay, siRNA knockdown, overexpression in mDPC6T cells, qRT-PCR, mineralization nodule assay Journal of cellular physiology Medium 23558921
2015 DMP1β, an alternative splice isoform of the DMP1 locus, is sufficient to induce mammary gland hyperplasia and multifocal tumor lesions in MMTV-DMP1β transgenic mice; it increases proliferation of non-tumourigenic mammary epithelial cells and has opposing oncogenic function relative to the tumor-suppressive DMP1α isoform. MMTV-DMP1β transgenic mouse lines, cell proliferation assays, histological tumor analysis, RNA-seq, knockdown of endogenous DMP1 The Journal of pathology High 25537728
2016 Glycosylation of DMP1 (at Ser89, the N-terminal proteoglycan form DMP1-PG) is essential for condylar cartilage chondrogenesis: S89G knock-in mice show reduced glycosylation, abnormal cartilage morphology, disordered chondrocyte arrangement, earlier TMJ osteoarthritis, downregulated chondrogenesis markers, and impaired TGF-β signaling in the mandibular condylar cartilage. S89G-DMP1 knock-in mouse model, histology, immunohistochemistry, Western blot, TGF-β pathway analysis, hyperocclusion model Journal of dental research Medium 28759313
2016 Fam20C phosphorylates the C-terminal fragment of DMP1 within the Golgi apparatus of osteoblastic and young osteocytes; phosphorylated C-terminal DMP1 is secreted into the pericanalicular matrix of mineralized bone. Colocalization of Fam20C and C-terminal DMP1 in the Golgi was confirmed by immunofluorescence; phosphorylated C-terminal DMP1 in canalicular walls was shown by double-labeling immunoelectron microscopy. Immunohistochemistry, immunofluorescence, double-labeling immunoelectron microscopy in rat bone; Fam20C/DMP1 colocalization Histochemistry and cell biology Medium 27614627
2019 DMP1 supplementation (genetic or pharmacological) in Col4a3-/- CKD mice prevents osteocyte apoptosis, preserves osteocyte networks, corrects bone mass, partially lowers FGF23 levels by attenuating NFAT-induced FGF23 transcription, and prevents left ventricular hypertrophy despite worsened hyperphosphatemia. CKD reduces endogenous DMP1 expression. Col4a3-/- CKD mouse model, genetic and pharmacological DMP1 supplementation, FGF23 ELISA, echocardiography, bone histomorphometry, NFAT pathway analysis Bone research Medium 31044094
2019 DMP1 and its receptor GRP78 form a complex at the plasma membrane of periodontal ligament stem cells; this complex is internalized via the caveolin pathway and trafficked through early (Rab5+) and late (Rab7+) endosomes. DMP1 is ultimately transported to the nucleus where it promotes osteogenic differentiation. Total internal reflection microscopy, confocal microscopy, co-immunoprecipitation, TIRF imaging of receptor-ligand complex formation/internalization, qRT-PCR Frontiers in physiology Medium 31572220
2014 Exogenous recombinant DMP1 acts as a direct, local negative regulator of FGF23 production in osteocytes/osteoblast-like cells: DMP1 treatment of UMR-106 and MC3T3-E1 cells significantly downregulates FGF23, and this effect is rescued by FAK inhibitor or MEK/ERK inhibitor, but not PI3K or ROCK inhibitors. DMP1 treatment elevates phospho-FAK, phospho-ERK, and phospho-p38, indicating FAK-mediated MAPK signaling mediates this effect. Recombinant DMP1 treatment of osteoblast/osteocyte-like cells, FGF23 ELISA, kinase inhibitors (FAK, MEK, PI3K, ROCK), Western blot for phosphoproteins, immunohistochemistry in rat femurs BoneKEy reports Medium 24991406
2012 Nuclear localization of DMP1 (specifically the 57-kDa C-terminal fragment) is observed in a subpopulation of non-synchronized mesenchymal and osteoblast-like cells, suggesting a potential intracellular/nuclear regulatory role in addition to its extracellular matrix function. Nuclear DMP1 is restricted to the nucleoplasm. Immunofluorescence of endogenous and HA-tagged exogenous DMP1, Western blot, RT-PCR in three cell lines Biochemical and biophysical research communications Low 22813642
2015 PTH downregulates DMP1 gene transcription (~85%) and protein expression (~30%) via the cAMP/PKA pathway in cementoblasts. This was confirmed in vivo by decreased DMP1 immunolocalization in cementum/alveolar bone of PTH-treated mice. RNA-seq revealed PTH and 1,25D share overlapping gene regulatory programs including DMP1 repression. qRT-PCR, Western blot, immunohistochemistry in PTH-treated mice, cAMP/PKA pathway inhibitors, RNA-seq Journal of dental research Medium 26276370
2024 A specific subset of Dmp1-expressing astrocytes regulates blood-brain barrier (BBB) integrity by transferring mitochondria to endothelial cells via their endfeet. Deletion of Mfn2 in Dmp1-expressing astrocytes inhibits mitochondrial transfer and causes BBB leakage. Age-associated reduction in MFN2 in astrocytes reduces mitochondrial transfer efficiency and BBB integrity. Dmp1-Cre conditional Mfn2 knockout, BBB permeability assays, mitochondria transfer imaging, confocal microscopy, aging comparison Science advances Medium 38941455

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nature genetics 865 17033621
2006 DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nature genetics 376 17033625
2007 DMP1-targeted Cre expression in odontoblasts and osteocytes. Journal of dental research 294 17384025
2011 Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 207 21507898
2009 Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease. Bone 200 19679205
2003 The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Journal of dental research 177 14514755
2007 Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. Journal of dental research 172 18037646
2004 Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. The Journal of biological chemistry 156 15590631
2005 DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 149 16294270
2003 Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 133 12733719
2007 Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology 127 18162525
1996 Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Molecular and cellular biology 124 8887674
2012 Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway. Critical reviews in eukaryotic gene expression 114 22339660
2008 Pathogenic role of Fgf23 in Dmp1-null mice. American journal of physiology. Endocrinology and metabolism 110 18559986
2011 The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 106 20734454
2006 Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Developmental biology 105 17196192
2005 Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Molecular and cellular biology 101 15601844
2001 Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes & development 96 11711428
2011 Primary structure and phosphorylation of dentin matrix protein 1 (DMP1) and dentin phosphophoryn (DPP) uniquely determine their role in biomineralization. Biomacromolecules 85 21736373
2000 Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes & development 82 10898794
2019 DMP1 prevents osteocyte alterations, FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease. Bone research 76 31044094
2017 Unintended targeting of Dmp1-Cre reveals a critical role for Bmpr1a signaling in the gastrointestinal mesenchyme of adult mice. Bone research 75 28163952
2010 Different forms of DMP1 play distinct roles in mineralization. Journal of dental research 73 20200415
2004 Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues. Journal of bone and mineral metabolism 73 15316863
1994 In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 73 7983353
2013 The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. The Journal of biological chemistry 71 23349460
2008 PHEX, FGF23, DMP1 and beyond. Current opinion in nephrology and hypertension 64 18660670
2012 Mutational analysis of PHEX, FGF23, DMP1, SLC34A3 and CLCN5 in patients with hypophosphatemic rickets. Journal of human genetics 63 22695891
2007 Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer cell 62 17936562
2007 Dmp1 and tumor suppression. Oncogene 59 17237816
2009 MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell. European cells & materials 56 19908197
1995 In situ hybridization shows Dmp1 (AG1) to be a developmentally regulated dentin-specific protein produced by mature odontoblasts. Connective tissue research 56 7554964
2010 Calcium-mediated stress kinase activation by DMP1 promotes osteoblast differentiation. The Journal of biological chemistry 54 20841352
2015 DMP1-derived peptides promote remineralization of human dentin. Journal of dental research 52 25694469
2008 Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. Journal of dental research 52 18573980
2008 Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone 52 19007919
2002 TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts. Connective tissue research 50 12489180
1997 Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. Genomics 49 9177774
2024 Regulation of blood-brain barrier integrity by Dmp1-expressing astrocytes through mitochondrial transfer. Science advances 48 38941455
2011 Dentin matrix protein 1 (DMP1) signals via cell surface integrin. The Journal of biological chemistry 45 21642437
2011 DMP1 processing is essential to dentin and jaw formation. Journal of dental research 44 21297011
2009 Identification of a novel dentin matrix protein-1 (DMP-1) mutation and dental anomalies in a kindred with autosomal recessive hypophosphatemia. Bone 44 19796717
1995 Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21. Genomics 43 8586437
2011 Mutational analysis of PHEX, FGF23 and DMP1 in a cohort of patients with hypophosphatemic rickets. Clinical endocrinology 42 21050253
2010 Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 42 20499351
1998 Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins. The Journal of biological chemistry 42 9786929
2008 Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells, tissues, organs 40 18728349
2013 KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1. Journal of cellular physiology 39 23558921
2010 Possible role of DMP1 in dentin mineralization. Journal of structural biology 39 21081166
2012 Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function. Cancer research 38 22331460
2016 Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer. International journal of cancer 37 26802432
2010 Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. The Journal of biological chemistry 37 20663874
2010 Critical roles of DMP1 in human epidermal growth factor receptor 2/neu-Arf-p53 signaling and breast cancer development. Cancer research 37 21062982
2014 A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes. Connective tissue research 36 25158197
2008 The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 36 18854597
2013 Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. The American journal of pathology 33 23938323
2012 Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice. Molecular endocrinology (Baltimore, Md.) 33 22930691
2007 Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65. Oncogene 33 17546045
2015 DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. The Journal of pathology 32 25537728
2010 The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1. International journal of cancer 32 19816943
2006 Expression of Dmp1 in specific differentiated, nonproliferating cells and its regulation by E2Fs. Oncogene 32 16878159
2015 Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix biology : journal of the International Society for Matrix Biology 31 26686820
2016 Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation. Bone 30 27143110
2011 DMP1 and DSPP: evidence for duplication and convergent evolution of two SIBLING proteins. Cells, tissues, organs 30 21555860
2011 Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo. Journal of the mechanical behavior of biomedical materials 29 22100074
2015 The role of dentin matrix protein 1 (DMP1) in regulation of osteogenic differentiation of rat dental follicle stem cells (DFSCs). Archives of oral biology 28 25596638
2010 Identification of secretory odontoblasts using DMP1-GFP transgenic mice. Bone 28 21172466
2019 DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27 30827034
2014 Functional heterogeneity of osteocytes in FGF23 production: the possible involvement of DMP1 as a direct negative regulator. BoneKEy reports 26 24991406
2012 Protective roles of DMP1 in high phosphate homeostasis. PloS one 25 22879941
2011 Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells, tissues, organs 25 21555863
2010 A novel nonsense mutation in the DMP1 gene in a Japanese family with autosomal recessive hypophosphatemic rickets. Journal of bone and mineral metabolism 25 20213538
2002 Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors. Connective tissue research 25 12489182
2012 Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochemical and biophysical research communications 24 22813642
2009 Dentin matrix protein 1 (DMP1) expression in developing human teeth. Brazilian dental journal 24 20126903
2018 Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network. Cancer investigation 23 30396285
2015 Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. Matrix biology : journal of the International Society for Matrix Biology 23 26721590
2010 DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 23 20499360
2008 Role of DMP1 and its future in lung cancer diagnostics. Expert review of molecular diagnostics 23 18598225
2023 Tissue engineering at the dentin-pulp interface using human treated dentin scaffolds conditioned with DMP1 or BMP2 plasmid DNA-carrying calcium phosphate nanoparticles. Acta biomaterialia 21 36708852
2017 Glycosylation of DMP1 Is Essential for Chondrogenesis of Condylar Cartilage. Journal of dental research 21 28759313
2016 Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization. Histochemistry and cell biology 20 27614627
2023 Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration. Materials today. Bio 19 38170028
2019 Endocytic Trafficking of DMP1 and GRP78 Complex Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells. Frontiers in physiology 19 31572220
2007 Dexamethasone promotes DMP1 mRNA expression by inhibiting negative regulation of Runx2 in multipotential mesenchymal progenitor, ROB-C26. Cell biology international 19 17950631
2016 Adult-Onset Deletion of β-Catenin in (10kb)Dmp1-Expressing Cells Prevents Intermittent PTH-Induced Bone Gain. Endocrinology 18 27253995
2014 Transcriptional regulation of dentin matrix protein 1 (DMP1) in odontoblasts and osteoblasts. Connective tissue research 18 25158192
2004 Expression of dentin matrix protein 1 (DMP1) during fracture healing. Bone 18 15268908
2000 Cloning and characterization of rat dentin matrix protein 1 (DMP1) gene and its 5'-upstream region. The Journal of biological chemistry 18 10744713
2020 ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice. Bone 17 33059101
2017 A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice. Endocrinology 17 28005411
2015 PTH and Vitamin D Repress DMP1 in Cementoblasts. Journal of dental research 17 26276370
2015 An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. European journal of histochemistry : EJH 17 26428891
2016 Dmp1 Null Mice Develop a Unique Osteoarthritis-like Phenotype. International journal of biological sciences 16 27766035
2008 Emerging roles of DMP1 in lung cancer. Cancer research 16 18559489
2019 C5L2 Regulates DMP1 Expression during Odontoblastic Differentiation. Journal of dental research 15 30702959
2019 Generation and characterization of DSPP-Cerulean/DMP1-Cherry reporter mice. Genesis (New York, N.Y. : 2000) 15 31271259
2018 Leptin stimulates DMP-1 and DSPP expression in human dental pulp via MAPK 1/3 and PI3K signaling pathways. Archives of oral biology 15 30476887
2012 DMP1 is a target of let-7 in dental pulp cells. International journal of molecular medicine 15 22552299
2010 Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice. Biomedical research (Tokyo, Japan) 15 21079361

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