Affinage

DENR

Density-regulated protein · UniProt O43583

Length
198 aa
Mass
22.1 kDa
Annotated
2026-04-28
100 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DENR is a specialized translation reinitiation and ribosome recycling factor that functions as an obligate heterodimer with MCTS1 on the 40S ribosomal subunit, where it occupies the eIF1-binding site and evicts residual tRNA from post-termination ribosomes to enable resumed scanning past short upstream open reading frames (uORFs) (PMID:28723557, PMID:30146315, PMID:32938922). The DENR N-terminal domain coordinates a zinc ion through four conserved cysteines that are essential for MCTS1 heterodimerization, while MCTS1 contributes a tRNA-binding surface required for reinitiation activity (PMID:30584092, PMID:29889857). Through this uORF-dependent reinitiation mechanism, DENR controls translation of functionally diverse mRNAs including ATF4 during the integrated stress response, CLOCK in circadian rhythm regulation, and JAK2 in interferon–JAK–STAT signaling (PMID:32938922, PMID:30982898, PMID:35440133). De novo missense mutations in DENR that disrupt its reinitiation activity cause a brain developmental disorder characterized by impaired cortical neuron migration and dendritic morphogenesis (PMID:27239039).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2016 High

    Establishing that DENR has an in vivo role in brain development answered whether DENR's reinitiation activity is physiologically relevant in mammals: DENR loss-of-function disrupted cortical neuron migration and dendritic arborization, and patient-derived missense mutations impaired reinitiation and neuronal positioning.

    Evidence In utero electroporation in mouse cortex with knockdown/overexpression; functional characterization of human de novo variants (C37Y, P121L) using translation reporters and migration assays

    PMID:27239039

    Open questions at the time
    • Full spectrum of neurodevelopmental phenotypes in DENR-mutant patients not characterized
    • Whether DENR controls specific neuronal target mRNAs during cortical development was not identified
  2. 2017 High

    Determining where DENR-MCTS1 binds the ribosome resolved how it interfaces with the translation machinery: the crystal structure showed DENR's C-terminal domain occupies the eIF1-binding site on the 40S subunit, immediately suggesting a mechanism for influencing scanning fidelity and reinitiation.

    Evidence X-ray crystallography of the human 40S–DENR-MCT-1 complex

    PMID:28723557

    Open questions at the time
    • How DENR displaces or competes with eIF1 during the transition from termination to reinitiation was not resolved
    • No cryo-EM structure of the full reinitiation-competent 40S complex with mRNA
  3. 2017 Medium

    Systematic analysis of uORF length dependence showed that DENR-MCTS1 is specifically required for reinitiation after very short (single-codon) uORFs, defining the substrate specificity of the complex and revealing enrichment of neuronal and GPCR transcripts among its targets.

    Evidence siRNA depletion of DENR/MCTS1 with stratified uORF-length translation reporters in human cells

    PMID:28623304

    Open questions at the time
    • No ribosome profiling validation of the ~100 predicted target transcripts in this study
    • Whether uORF length or peptide identity determines DENR dependence was unresolved
  4. 2018 High

    Structural and mutagenic dissection of the DENR-MCTS1 interface established the molecular basis of heterodimerization: a zinc ion coordinated by four DENR cysteines is essential for complex formation, and MCTS1 Phe104 is critical for tRNA binding, demonstrating that both dimerization and tRNA engagement are required for reinitiation.

    Evidence X-ray crystallography of MCTS1–DENR N-terminal domain at 2.0 Å; cysteine-to-alanine and point mutagenesis with binding and reinitiation reporter assays

    PMID:29889857 PMID:30584092

    Open questions at the time
    • Whether DENR-MCTS1 delivers initiator tRNA analogously to eIF2 or removes deacylated tRNA was not fully resolved
    • No structure of the full-length heterodimer in the context of mRNA
  5. 2018 High

    Ribosome profiling in yeast demonstrated that Tma20/Tma22 (MCTS1/DENR orthologs) are the primary 40S recycling factors at stop codons, resolving the long-standing question of how post-termination 40S subunits are recycled: without these factors, 80S ribosomes queued behind stop codons and reinitiated aberrantly in 3′ UTRs.

    Evidence Ribosome profiling of yeast tma deletion strains; in vitro translation with uORF-containing reporters

    PMID:30146315

    Open questions at the time
    • Whether the recycling and reinitiation functions are mechanistically separable was unclear
    • Quantitative contribution of DENR vs. eIF2D to recycling in mammalian cells not determined
  6. 2020 High

    Two independent studies converged on DENR-MCTS1 as essential mediators of ATF4 translational induction during the integrated stress response, demonstrating that DENR promotes reinitiation after specific uORFs whose penultimate codon identity determines DENR dependence — consistent with a tRNA-eviction mechanism.

    Evidence DENR/MCTS1 depletion in human cells with ATF4 reporters and ribosome profiling; Drosophila loss-of-function genetics under ER stress and amino acid deprivation

    PMID:32938922 PMID:32938929

    Open questions at the time
    • Direct biochemical demonstration of penultimate-codon-specific tRNA eviction is lacking
    • Whether DENR regulation of ATF4 is relevant in all stress contexts or tissue-specific is unknown
  7. 2021 High

    40S-specific ribosome footprinting directly captured DENR-dependent recycling intermediates in vivo and showed that an autism-associated DENR mutation abolishes recycling, linking DENR's ribosome recycling activity to a specific neurological condition.

    Evidence 40S ribosome footprinting in yeast; analysis of autism-associated TMA22 (DENR) point mutant

    PMID:34016977

    Open questions at the time
    • The autism-associated variant was characterized only in yeast, not in mammalian neurons
    • Causal relationship between DENR recycling deficiency and autism pathophysiology in patients remains unestablished
  8. 2022 High

    Identification of JAK2 as a direct DENR reinitiation target connected DENR to tumor immune evasion: DENR deficiency reduced JAK2 translation, impaired IFN-γ–JAK–STAT signaling, lowered PD-L1, and enhanced CD8+ T cell–mediated tumor killing.

    Evidence Targeted CRISPR screen for RNA-binding proteins; DENR depletion with JAK2 translation, PD-L1, and in vivo tumor models; uORF reporter assays

    PMID:35440133

    Open questions at the time
    • Whether DENR's effect on tumor immunity generalizes across cancer types is untested
    • Therapeutic feasibility of targeting DENR for immune checkpoint modulation is unexplored

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the direct biochemical mechanism by which DENR-MCTS1 selectively evicts specific deacylated tRNAs, the full mammalian target mRNA repertoire beyond known examples, and whether DENR and eIF2D have redundant or distinct roles in different tissues and stress conditions.
  • No reconstituted biochemical assay demonstrating penultimate-codon-selective tRNA eviction
  • Comprehensive tissue-resolved ribosome profiling of DENR-deficient mammals not performed
  • Functional redundancy between DENR-MCTS1 and eIF2D in mammalian systems not systematically addressed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0045182 translation regulator activity 5 GO:0005198 structural molecule activity 2
Localization
GO:0005840 ribosome 3 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 6 R-HSA-8953854 Metabolism of RNA 3 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-168256 Immune System 1
Partners
MCTS1
Complex memberships
DENR-MCTS1 heterodimer

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 Crystal structure of the human small ribosomal subunit in complex with DENR-MCT-1 revealed that the C-terminal domain of DENR binds the small ribosomal subunit at a site strikingly similar to that of canonical initiation factor eIF1, which controls fidelity of translation initiation and scanning. X-ray crystallography of human 40S ribosome–DENR-MCT-1 complex Cell reports High 28723557
2018 Crystal structure of MCTS1 bound to a fragment of DENR identified that DENR residues Glu42, Tyr43, and Tyr46 are critical for MCTS1 binding, and MCTS1 residue Phe104 is important for tRNA binding; mutagenesis confirmed that both DENR–MCTS1 dimerization and tRNA binding are necessary for the complex to promote translation reinitiation in human cells, suggesting that DENR–MCTS1 recruits tRNA to the ribosome analogously to eIF2 during canonical initiation. X-ray crystallography of MCTS1–DENR fragment complex, site-directed mutagenesis, in-cell translation reinitiation reporter assays PLoS biology High 29889857
2018 Crystal structure of the human MCT-1–DENR N-terminal domain heterodimer at 2.0-Å resolution revealed that four conserved DENR cysteines (C34, C37, C44, C53) coordinate a zinc ion essential for maintaining the MCT-1-binding interface; substitution of all four cysteines abolished heterodimer formation. X-ray crystallography; cysteine-to-alanine mutagenesis with binding assays Proceedings of the National Academy of Sciences of the United States of America High 30584092
2018 In yeast, Tma22 (the DENR ortholog) together with Tma20 (MCT-1) and Tma64 (eIF2D) function as 40S recycling factors in vivo; deletion of these genes caused 80S ribosomes to queue behind stop codons (ribosome profiling), and unrecycled ribosomes reinitiated translation at downstream AUG codons in 3′ UTRs. Ribosome profiling of yeast tma deletion strains; in vitro translation reporter assays with uORF-containing mRNAs Molecular cell High 30146315
2021 Using 40S ribosome footprinting in yeast, the Tma20/Tma22 (MCT-1/DENR) heterodimer was shown to be responsible for the majority of 40S recycling events at stop codons; an autism-associated mutation in TMA22 (DENR) abolished 40S recycling activity, linking DENR-dependent ribosome recycling to neurological disease. 40S-specific ribosome footprinting; genetic deletion and autism-associated point-mutant analysis in yeast Nature communications High 34016977
2020 DENR and MCTS1 are required for translation reinitiation in the ATF4 5′ UTR upon cellular stress; DENR and MCTS1 are specifically needed for reinitiation after uORFs containing certain penultimate codons, suggesting they evict particular tRNAs from post-termination 40S ribosomes to enable resumption of scanning. Genetic depletion of DENR/MCTS1 in human cells with ATF4 translation reporters; ribosome profiling Nature communications High 32938922
2020 eIF2D and DENR are critical mediators of ATF4 translational induction during integrated stress response in Drosophila and human cells; eIF2D requires its RNA-binding motif for regulation of 5′ leader-mediated ATF4 translation, and DENR/eIF2D-deficient human cells show impaired ATF4 protein induction in response to ER stress. Drosophila loss-of-function genetics (amino acid deprivation, ER stress phenotypes); human cell knockdown with ATF4 reporter assays; eIF2D RNA-binding domain mutagenesis Nature communications High 32938929
2017 In human cells, transcripts with very short stuORFs (coding for 1 amino acid) require DENR and MCTS1 for optimal translation; DENR/MCTS1-dependent target transcripts are enriched for neuronal genes and G protein-coupled receptors, identifying ~100 genes as putative targets. DENR/MCTS1 depletion (siRNA) combined with translation reporter assays stratified by uORF length in human cells Scientific reports Medium 28623304
2016 DENR influences migration of murine cerebral cortical neurons in vivo together with its binding partner MCTS1; perturbations to DENR impair long-term neuronal positioning, dendritic arborization, and dendritic spine characteristics. De novo missense mutations in DENR (p.C37Y and p.P121L) found in patients with brain developmental disorder impair DENR function in mRNA translation reinitiation and disrupt cortical neuron migration and terminal branching. In utero electroporation of mouse cortex (knockdown/overexpression); in vivo Denr knockout; human patient variant functional characterization with translation reporters and cortical neuron migration assays Cell reports High 27239039
2019 DENR depletion shortens circadian period in mouse fibroblasts; ribosome profiling of DENR-deficient NIH3T3 cells identified 240 transcripts with altered translation rate, and Clock was identified as a direct DENR target—DENR regulates CLOCK protein biosynthesis through a specific uORF in the Clock 5′ UTR. Ribosome profiling in DENR-deficient NIH3T3 cells; Clock 5′ UTR mutagenesis; circadian period measurement Nucleic acids research High 30982898
2022 DENR promotes translation of JAK2 mRNA by antagonizing translational repression imposed by three consecutive uORFs upstream of JAK2; DENR deficiency impairs JAK2 translation, reduces IFNγ-JAK-STAT signaling, and consequently lowers PD-L1 expression in tumor cells, thereby enhancing CD8+ T cell tumor-killing activity. Targeted RBP CRISPR/Cas9 screen; DENR depletion with JAK2 translation and PD-L1 expression assays; in vivo tumor models; uORF reporter assays Nature communications High 35440133

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass. Nature communications 327 31189900
2018 Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature 302 29899447
2020 Drp1-dependent mitochondrial fission in cardiovascular disease. Acta pharmacologica Sinica 292 32913266
2005 DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 280 15716954
2018 Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. Cell metabolism 270 29478834
2016 Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. Journal of cell science 263 27076521
2020 Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction. Circulation research 219 31896304
2011 PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics. The Journal of neuroscience : the official journal of the Society for Neuroscience 177 22049414
2019 Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction. Theranostics 175 31037132
2020 Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy. Journal of neuroinflammation 161 31987040
2019 Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy. Journal of molecular and cellular cardiology 157 30981733
2020 The role of Drp1 in mitophagy and cell death in the heart. Journal of molecular and cellular cardiology 153 32302592
2014 Functional interplay between Parkin and Drp1 in mitochondrial fission and clearance. Biochimica et biophysica acta 131 24878071
2020 Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis. Cell death & disease 125 31949126
2014 Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death. Biochemical and biophysical research communications 124 25445585
2022 Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway. Journal of experimental & clinical cancer research : CR 122 35209954
2022 DRP1 interacts directly with BAX to induce its activation and apoptosis. The EMBO journal 117 35023587
2022 Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug. Science advances 96 36383674
2022 Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1. Cell death & disease 86 35697672
2022 Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation. Hepatology (Baltimore, Md.) 86 35698731
2011 Role of Drp1, a key mitochondrial fission protein, in neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 86 21813700
2009 Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research 85 19188258
2020 Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury. Cell death and differentiation 84 33110216
2015 CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death. Human molecular genetics 80 26002103
2020 Neuropathic Pain: the Dysfunction of Drp1, Mitochondria, and ROS Homeostasis. Neurotoxicity research 78 32696439
2017 DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell metabolism 77 28190775
2014 Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PloS one 75 24632637
2009 HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Nucleic acids research 74 19465398
2021 ERK1/2-mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes. Osteoarthritis and cartilage 73 34767958
2020 DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4. Nature communications 73 32938922
2020 Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. The Journal of physiology 71 32539155
2020 Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Nature communications 71 32938929
2017 Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell death & disease 70 28981113
2018 PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons. Cell death & disease 69 30158524
2014 Dysregulation of Mfn2 and Drp-1 proteins in heart failure. Canadian journal of physiology and pharmacology 69 24905188
2017 RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Experimental neurology 68 28579326
2018 Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo. Molecular cell 67 30146315
2020 New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology. Pharmacology & therapeutics 66 32473962
2001 Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. The EMBO journal 64 11230133
2023 Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy. Circulation research 62 37232152
2021 Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2. Cell death & disease 62 34741026
2014 Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division. The Journal of biological chemistry 61 25237193
2019 Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer. Cancer letters 58 31838085
2015 Blockade of Drp1 rescues oxidative stress-induced osteoblast dysfunction. Biochemical and biophysical research communications 56 26577411
2019 Targeting Drp1 and mitochondrial fission for therapeutic immune modulation. Pharmacological research 54 31220561
2022 ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation. Pharmacological research 53 36566000
2024 Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury. Cellular & molecular biology letters 52 38439028
2020 Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience 52 32144179
2017 Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1. Cell reports 51 28723557
2022 DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nature communications 49 35440133
2019 Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss. Frontiers in cellular neuroscience 48 31920551
2010 Plant dynamin-related protein families DRP1 and DRP2 in plant development. Biochemical Society transactions 48 20491667
2016 A threshold of transmembrane potential is required for mitochondrial dynamic balance mediated by DRP1 and OMA1. Cellular and molecular life sciences : CMLS 47 27858084
2017 Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells. Scientific reports 46 28623304
2020 Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury. Arteriosclerosis, thrombosis, and vascular biology 45 32493171
2022 A novel small molecule inhibitor of human Drp1. Scientific reports 43 36513726
2016 Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury. Histology and histopathology 42 27830583
2014 MiRNA-30a inhibits AECs-II apoptosis by blocking mitochondrial fission dependent on Drp-1. Journal of cellular and molecular medicine 41 25284615
2019 Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. eLife 40 31603426
2018 Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein. Molecular and cellular neurosciences 40 29414102
2025 Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell death & disease 39 39863602
2018 Adrenergic Regulation of Drp1-Driven Mitochondrial Fission in Cardiac Physio-Pathology. Antioxidants (Basel, Switzerland) 36 30567380
2016 Silencing Drp1 inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 pathway. Biochemical and biophysical research communications 36 27495873
2018 DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. PLoS biology 35 29889857
2014 Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection. International journal of medical microbiology : IJMM 34 24755420
2022 Cystathionine γ lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction. Redox biology 33 36327794
2021 Inhibition of mitochondrial fission by Drp-1 blockade by short-term leptin and Mdivi-1 treatment improves white adipose tissue abnormalities in obesity and diabetes. Pharmacological research 33 34896541
2024 Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling. Journal of translational medicine 32 38773615
2021 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling. Nature communications 32 34016977
2017 SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis. Molecular and cellular biology 32 27799292
2024 MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1. Cardiovascular diabetology 31 38724987
2022 TBK1-medicated DRP1 phosphorylation orchestrates mitochondrial dynamics and autophagy activation in osteoarthritis. Acta pharmacologica Sinica 31 36008706
2017 DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. Cell death & disease 30 28079887
2016 De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. Cell reports 30 27239039
2025 DRP1, fission and apoptosis. Cell death discovery 29 40195359
2022 Mitochondrial fission mediated by Drp1-Fis1 pathway and neurodegenerative diseases. Reviews in the neurosciences 29 36059131
2019 Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock. Nucleic acids research 27 30982898
2016 Parkin suppresses Drp1-independent mitochondrial division. Biochemical and biophysical research communications 27 27181353
2022 CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60. Cell reports 26 35417690
2022 Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis. Experimental eye research 26 35490835
2020 JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell death and differentiation 25 32346136
2024 Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1. Pharmacological research 24 39643069
2022 Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1-Drp1 signalling pathway. Cell proliferation 24 35842903
2019 The role of DRP1 in ropivacaine-induced mitochondrial dysfunction and neurotoxicity. Artificial cells, nanomedicine, and biotechnology 24 31062606
2024 ISGylation of DRP1 closely balances other post-translational modifications to mediate mitochondrial fission. Cell death & disease 23 38431611
2022 CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I. Nature communications 23 36513638
2021 Melatonin abated Bisphenol A-induced neurotoxicity via p53/PUMA/Drp-1 signaling. Environmental science and pollution research international 23 33398767
2021 The role of DRP1- PINK1-Parkin-mediated mitophagy in early cadmium-induced liver damage. Toxicology 23 34952138
2018 BH3 mimetics induce apoptosis independent of DRP-1 in melanoma. Cell death & disease 23 30185782
2016 [Mechanism of mitochondrial fission - structure and function of Drp1 protein]. Postepy biochemii 23 28132464
2024 RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling. Metabolism: clinical and experimental 20 39089491
2023 Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction. Cell chemical biology 20 36827981
2023 miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress. BMC pharmacology & toxicology 20 36882858
2023 Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy. Cell death & disease 20 37980402
2022 SUMOylation of SYNJ2BP-COX16 promotes breast cancer progression through DRP1-mediated mitochondrial fission. Cancer letters 20 35998797
2021 FAK regulates cardiomyocyte mitochondrial fission and function through Drp1. The FEBS journal 20 34739186
2015 Gone fission…: diverse consequences of cardiac Drp1 deficiency. Circulation research 20 25593271
2024 A partial Drp1 knockout improves autophagy flux independent of mitochondrial function. Molecular neurodegeneration 19 38504290
2018 Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation. Proceedings of the National Academy of Sciences of the United States of America 19 30584092
2014 Requirements for 5'dRP/AP lyase activity in Ku. Nucleic acids research 19 25200085