Affinage

DCN

Decorin · UniProt P07585

Round 2 corrected
Length
359 aa
Mass
39.7 kDa
Annotated
2026-04-28
87 papers in source corpus 21 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Decorin (DCN) is a secreted small leucine-rich proteoglycan that orchestrates extracellular matrix architecture and growth factor signaling by acting simultaneously as a collagen-binding scaffold, a TGF-β sequestrant, and an antagonistic ligand of receptor tyrosine kinases. The DCN core protein binds TGF-β1/2/3 with nanomolar affinity, neutralizing TGF-β bioactivity; MMP-2, MMP-3, and MMP-7 proteolytically degrade DCN at defined leucine residues, releasing sequestered TGF-β and providing a regulated mechanism for TGF-β mobilization (PMID:2374594, PMID:9148753). DCN also binds EGFR (Kd ~87 nM) and Met (Kd ~1.5 nM), triggering transient receptor activation that leads to p21-dependent cell cycle arrest (via EGFR/MAPK) and c-Cbl-mediated ubiquitination and degradation of Met with consequent β-catenin suppression (PMID:9988678, PMID:19433454). Beyond its matrix and RTK functions, DCN is released during ferroptosis via secretory autophagy and signals through AGER/NF-κB on macrophages to elicit innate immune cytokine responses (PMID:34964698).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1986 High

    Cloning the DCN cDNA revealed the primary structure of a leucine-rich repeat proteoglycan, establishing the molecular identity of decorin as a secreted SLRP.

    Evidence cDNA library screening, protein sequencing, and RNA blot from human fibroblasts

    PMID:2647739 PMID:3484330

    Open questions at the time
    • Biological function of the leucine-rich repeat architecture was unknown
    • Binding partners of the core protein had not been identified
  2. 1990 High

    Discovery that DCN directly binds and neutralizes TGF-β provided the first mechanistic explanation for its growth-inhibitory activity, identifying DCN as an extracellular TGF-β trap.

    Evidence Co-immunoprecipitation of decorin–TGF-β complex and functional growth suppression assay in CHO cells

    PMID:2374594 PMID:3194009

    Open questions at the time
    • Affinity constants for TGF-β isoforms had not been quantified
    • Whether the GAG chain contributed to TGF-β binding was unresolved
  3. 1992 High

    Identification of collagen VI as a direct ligand of DCN's protein core (Kd ~300 nM) established DCN as a bifunctional molecule linking matrix architecture to growth factor regulation.

    Evidence Solid-phase binding assay with radiolabeled decorin and recombinant core protein competition

    PMID:1544908

    Open questions at the time
    • Structural basis of the collagen VI–DCN interaction was not determined
    • In vivo consequences of disrupting DCN–collagen VI binding were unknown
  4. 1994 High

    Quantitative binding studies revealed a two-site model for DCN–TGF-β interaction (high-affinity Kd ~1–20 nM) and showed that DCN competes with betaglycan and type I but not type II TGF-β receptors, clarifying its mechanism of TGF-β antagonism.

    Evidence Radioligand binding with recombinant maltose-binding-protein fusion cores, competitive binding on cells, affinity labeling

    PMID:8093006

    Open questions at the time
    • The precise binding epitope on DCN for TGF-β was unmapped
    • Whether DCN–TGF-β sequestration operates in all tissue contexts was unclear
  5. 1997 High

    Demonstration that MMP-2, MMP-3, and MMP-7 cleave DCN at specific leucine residues and liberate sequestered TGF-β1 revealed a protease-dependent mechanism for regulated TGF-β release from the matrix.

    Evidence In vitro enzymatic cleavage with kinetic parameters, N-terminal sequencing, TGF-β release assay

    PMID:9148753

    Open questions at the time
    • In vivo relevance of MMP-mediated DCN cleavage in disease contexts was not established
    • Whether other proteases contribute remained unexplored
  6. 1999 High

    Identification of EGFR as a direct DCN receptor (Kd ~87 nM) and mapping of the interaction to LRR6 on DCN and the L2 domain of EGFR established a receptor tyrosine kinase signaling axis through which DCN induces p21-dependent cell cycle arrest.

    Evidence Radioligand binding, dimerization and autophosphorylation assays with purified components, expression cloning screen, and site-directed mutagenesis

    PMID:12105206 PMID:9435313 PMID:9988678

    Open questions at the time
    • Structural model of the DCN–EGFR complex was lacking
    • How transient EGFR activation leads to growth suppression rather than mitogenesis was mechanistically incomplete
  7. 2009 High

    Discovery that DCN binds Met with very high affinity (Kd ~1.5 nM) and triggers c-Cbl-mediated Met degradation (t½ ~6 min) expanded DCN's anti-oncogenic mechanism beyond EGFR to a second RTK, explaining suppression of β-catenin and cell migration.

    Evidence Direct binding/displacement assays, co-immunoprecipitation of c-Cbl, pulse-chase receptor degradation, functional migration assays

    PMID:19433454

    Open questions at the time
    • Whether DCN targets additional RTKs was unknown
    • The relative contribution of EGFR versus Met antagonism in vivo was unresolved
  8. 2012 Medium

    OTUB1 was identified as a DCN-interacting protein that paradoxically promotes DCN ubiquitination and proteasomal degradation, revealing a post-translational mechanism for DCN turnover during inflammation.

    Evidence Co-immunoprecipitation and ubiquitination assay in rat mesangial cells with OTUB1 overexpression

    PMID:22279542

    Open questions at the time
    • OTUB1 is a deubiquitinase, so the pro-ubiquitination mechanism is paradoxical and unexplained
    • Not independently confirmed in a second cell type or species
    • The ubiquitin linkage type on DCN was not characterized
  9. 2014 High

    Epigenetic silencing of DCN via +58CpG methylation, which displaces the transcriptional activator AhR, was shown to derepress TGF-β/Smad signaling in metastatic NSCLC cells, linking DCN transcriptional regulation to cancer progression.

    Evidence Bisulfite sequencing, ChIP, EMSA, luciferase reporter, and 5-Aza demethylation rescue in NSCLC cell lines

    PMID:24424784

    Open questions at the time
    • Whether +58CpG methylation operates in non-lung cancers was untested
    • The upstream signals that direct methylation at this site were not identified
  10. 2021 High

    DCN was identified as a damage-associated molecular pattern released during ferroptosis via secretory autophagy and lysosomal exocytosis; extracellular DCN binds AGER on macrophages and activates NF-κB-dependent cytokine production, establishing a new immunological function.

    Evidence Pharmacological and genetic inhibition of secretory autophagy/lysosomal exocytosis, DCN–AGER co-immunoprecipitation, NF-κB reporter, in vivo acute pancreatitis model

    PMID:34964698

    Open questions at the time
    • Whether AGER is the sole macrophage receptor for ferroptosis-released DCN is unconfirmed
    • The relationship between DCN's AGER signaling and its RTK-antagonistic functions is unexplored
  11. 2024 Medium

    Loss of stromal DCN was shown to activate STAT3/AUF1 signaling in fibroblasts, driving cancer-associated fibroblast conversion that promotes epithelial-to-mesenchymal transition paracrinally, revealing DCN as a suppressor of the CAF phenotype.

    Evidence siRNA knockdown and ectopic DCN expression in breast stromal fibroblasts, STAT3/AUF1 pathway analysis, orthotopic mouse model

    PMID:38667295

    Open questions at the time
    • The direct molecular link between DCN loss and STAT3 phosphorylation is undefined
    • Single study in breast cancer stroma; generalizability to other tumor types is untested
  12. 2025 Medium

    EGR3 was identified as a direct transcriptional activator of DCN, and a DCN/HIF1A axis was shown to protect hepatocytes from oxidative injury, broadening understanding of DCN transcriptional control and cytoprotective signaling.

    Evidence ChIP and luciferase reporter for EGR3–DCN promoter binding; overexpression/knockdown and HIF1A inhibitor rescue in hepatocyte oxidative stress model

    PMID:40660758 PMID:41468793

    Open questions at the time
    • The mechanism by which extracellular DCN upregulates intracellular HIF1A is unknown
    • EGR3-driven DCN regulation has been shown only in liver cancer cells
    • Relationship between EGR3 and AhR/methylation-dependent DCN regulation is unexplored

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structural model of DCN in complex with EGFR, Met, or AGER is lacking, and the relative in vivo contribution of each receptor axis to DCN's tumor-suppressive and immunomodulatory functions remains undefined.
  • No co-crystal or cryo-EM structure of DCN bound to any of its RTK or AGER partners
  • In vivo genetic dissection separating TGF-β sequestration from RTK antagonism has not been performed
  • Whether DCN's DAMP/AGER function and its matrix/RTK functions are coordinated or independent is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0048018 receptor ligand activity 4 GO:0140313 molecular sequestering activity 3 GO:0005198 structural molecule activity 1
Localization
GO:0031012 extracellular matrix 4 GO:0005576 extracellular region 3
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1643685 Disease 2 R-HSA-168256 Immune System 1
Partners
AGERCOL6A1EGFREGR3METOTUB1TGFB1

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1986 The decorin (DCN) core protein was cloned from a human fibroblast cDNA library, revealing a prepro-protein of 329 amino acids with a signal peptide, propeptide, and mature core containing leucine-rich repeats; the protein is expressed as two related transcripts (~1.6 and ~1.9 kb) from a single gene. cDNA cloning, cDNA library screening with antibodies, protein sequencing, RNA blot hybridization Proceedings of the National Academy of Sciences of the United States of America High 3484330
1988 Stable ectopic expression of human decorin in Chinese hamster ovary (CHO) cells suppresses cell proliferation and reduces saturation density by more than 50%, demonstrating a direct growth-inhibitory role for DCN. Stable cDNA transfection in CHO cells, growth curve / saturation density assays Nature High 3194009
1989 DCN core protein contains a series of leucine-rich repeats homologous to those in biglycan and other LRR-domain proteins, establishing the structural basis of the SLRP family. cDNA cloning and protein sequence comparison The Journal of biological chemistry High 2647739
1990 Decorin binds directly to TGF-β and neutralizes its activity; CHO cells overexpressing decorin show growth suppression that is attributable at least in part to sequestration of autocrine TGF-β, placing DCN in a feedback loop regulating cell growth. Co-immunoprecipitation / binding assay (decorin–TGF-β complex), functional growth assay in CHO cells with TGF-β neutralization Nature High 2374594
1990 The DCN gene was mapped to human chromosome 12p12.1-qter by Southern analysis of somatic cell hybrids. Southern blot analysis of human-rodent somatic cell hybrid panel Genomics Medium 1968422
1992 DCN binds directly to collagen type VI via its protein core (not the glycosaminoglycan chain) with moderate affinity (Kd ~300 nM), as shown by solid-phase binding assays with recombinant core protein and competitive inhibition. Solid-phase binding assay with 125I-decorin, recombinant fusion protein competition, isolated core protein competition The Journal of biological chemistry High 1544908
1992 DCN is actively transcribed in mesenchymal cells but not in endothelial or epithelial cells in culture; in situ hybridization placed the single DCN gene to chromosome 12q21–q22. Northern blot, in situ hybridization on human tissues and cell lines Cytogenetics and cell genetics Medium 1611907
1994 DCN core protein (and those of biglycan and fibromodulin) binds TGF-β1, -β2, and -β3 with a two-site model (high-affinity Kd ~1–20 nM, low-affinity Kd ~50–200 nM); the glycosaminoglycan chain of decorin partially hinders TGF-β binding; decorin competes with betaglycan and type-I receptors but not type-II receptors for TGF-β binding on cells. Radioligand binding assay with maltose-binding-protein fusion cores, affinity measurements, competitive binding on Mv 1 Lu and endothelial cells, affinity labeling The Biochemical journal High 8093006
1997 DCN is cleaved by MMP-2, MMP-3, and MMP-7 (but not MMP-1 or MMP-9); specific cleavage sites were identified (Leu211 and Leu244 region); MMP-7 has ~4.5-fold higher catalytic efficiency (kcat/Km) than MMP-2/3; MMP-mediated degradation of DCN releases bound TGF-β1 from the DCN–TGF-β1 complex. In vitro enzymatic cleavage, N-terminal sequencing of fragments, kinetic analysis (Km, kcat), TGF-β release assay The Biochemical journal High 9148753
1998 Decorin activates the EGF receptor (EGFR) and downstream MAP kinase, induces endogenous p21 (CDKN1A), and causes cell cycle arrest in A431 squamous carcinoma cells; this pathway is responsible for decorin's growth-suppressive effect. Exogenous protein addition and transgene expression, EGFR/MAP kinase phosphorylation assays, p21 induction by Western blot, growth suppression assay The Journal of clinical investigation High 9435313
1999 Decorin directly binds the EGFR ectodomain with Kd ~87 nM via its protein core; binding induces EGFR dimerization, autophosphorylation, and MAP kinase activation, and decorin also acts as an EGFR kinase substrate in a cell-free system. Radioligand binding assays with immobilized/soluble decorin and EGFR ectodomain, cell-free autophosphorylation assay, dimerization assay The Journal of biological chemistry High 9988678
2002 Decorin binds to a specific narrow region in the L2 ligand-binding domain of EGFR; the central leucine-rich repeat 6 of decorin is required for EGFR interaction; a cluster of residues His394–Ile402 in EGFR is essential for decorin binding (partially overlapping but distinct from the EGF-binding epitope). Expression cloning screen (decorin/alkaline phosphatase chimera vs. cDNA library), yeast two-hybrid, EGFR deletion mutant panel, site-directed mutagenesis The Journal of biological chemistry High 12105206
2009 Decorin directly binds the Met receptor (HGF receptor) with high affinity (Kd ~1.5 nM); binding induces transient Met activation, recruitment of the E3 ubiquitin ligase c-Cbl, and rapid intracellular degradation of Met (half-life ~6 min); decorin thereby suppresses β-catenin levels and inhibits Met-mediated cell migration and growth. Direct binding assay, displacement by HGF and internalin B, co-immunoprecipitation of c-Cbl, pulse-chase degradation assay, β-catenin Western blot, migration and growth assays The Journal of cell biology High 19433454
2012 DCN has a broad binding repertoire including collagens (collagen I, VI), TGF-β ligands, and multiple receptor tyrosine kinases (EGFR, Met); it antagonizes pro-tumorigenic signals by sequestering growth factors and directly down-regulating RTK activity in the tumor stroma. Review synthesizing binding assay, co-IP, cell-based functional data from multiple primary studies The American journal of pathology High 22735579
2012 OTUB1, a deubiquitinase, interacts with DCN protein in mesangial cells (co-immunoprecipitation); OTUB1 overexpression promotes ubiquitination and proteasomal degradation of DCN, thereby reducing DCN levels during inflammatory glomerular injury. Co-immunoprecipitation, ubiquitination assay, overexpression of OTUB1, Western blot and quantitative RT-PCR in cultured rat mesangial cells PloS one Medium 22279542
2014 Methylation of the +58CpG site in the DCN 5'-UTR reduces binding of the transcriptional activator AhR to this site, causing ~50% reduction in DCN transcriptional activity; this epigenetic silencing of DCN in high-metastatic NSCLC cells leads to elevated p-Smad3 and reduced E-cadherin, promoting TGF-β/Smad signaling. Bisulfite sequencing, ChIP assay, EMSA, luciferase reporter assay, 5-Aza demethylation rescue, Western blot International journal of oncology High 24424784
2015 DCN overexpression in renal cell carcinoma cells significantly upregulates p21 and E-cadherin, suppressing proliferation and metastasis in vitro and in vivo. Gain-of-function (DCN cDNA transfection), proliferation and invasion assays in vitro, xenograft in vivo, Western blot for p21 and E-cadherin Tumour biology Medium 26547587
2021 During ferroptosis, DCN is actively released from dying cells via secretory autophagy and lysosomal exocytosis; extracellular DCN then binds AGER (RAGE) on macrophages and triggers NF-κB-dependent production of pro-inflammatory cytokines, mediating the immune consequences of ferroptotic death. Inhibition of secretory autophagy and lysosomal exocytosis (pharmacological and genetic), co-immunoprecipitation/binding of DCN with AGER, cytokine assays, NF-κB reporter, in vivo models of acute pancreatitis Autophagy High 34964698
2024 DCN knockdown in breast stromal fibroblasts activates the STAT3/AUF1 signaling axis, upregulates CAF biomarkers (α-SMA, FAP-α, SDF-1, IL-6), and promotes epithelial-to-mesenchymal transition and stemness in breast cancer cells in a paracrine manner; ectopic DCN expression in CAFs reverses these pro-carcinogenic effects. siRNA knockdown and ectopic expression of DCN, Western blot, invasion/proliferation assays, STAT3/AUF1 pathway analysis, orthotopic tumor mouse model Cells Medium 38667295
2025 EGR3 directly binds to the DCN promoter and acts as a transcriptional activator of DCN in liver cancer cells; EGR3 knockdown reduces DCN expression and reverses DCN's tumor-suppressive effects on proliferation, apoptosis, invasion, and migration. ChIP assay, luciferase reporter assay, siRNA knockdown of EGR3, rescue co-transfection (si-EGR3 + pcDNA3.1-DCN), functional assays (CCK-8, colony formation, flow cytometry, Transwell) Journal of biochemical and molecular toxicology Medium 40660758
2025 Dcn overexpression protects hepatocytes from H2O2-induced injury by upregulating HIF1A; pharmacological inhibition of HIF1A reverses this protective effect, establishing a Dcn/HIF1A axis that modulates hepatocyte proliferation, apoptosis, autophagy, and oxidative stress. Overexpression and knockdown plasmids in BRL cells, H2O2 injury model, HIF1A inhibitor (LW6), cell viability/cycle/autophagy/oxidative stress assays International immunopharmacology Medium 41468793
2025 Controlled release of DCN protein from hyaluronic acid microgels suppresses vocal fold myofibroblast activation by reducing pro-fibrotic gene expression, α-SMA levels, and cell contractility; in a rat vocal fold scarring model, DCN-loaded microgels prevented collagen deposition and myofibroblast accumulation. Transcriptomics of human VF myofibroblasts, DCN protein treatment with functional readouts (α-SMA, gene expression, contractility), microgel encapsulation, in vivo rat VF scarring model with histological analysis bioRxiv (preprint)preprint Medium

Source papers

Stage 0 corpus · 87 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 1408 2374594
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix biology : journal of the International Society for Matrix Biology 901 25701227
1994 Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. The Biochemical journal 840 8093006
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1989 Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. The Journal of biological chemistry 636 2647739
1986 Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA. Proceedings of the National Academy of Sciences of the United States of America 558 3484330
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell 423 26871637
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
1987 Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. The Journal of biological chemistry 389 3597437
1997 Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. The Biochemical journal 353 9148753
1999 Decorin is a biological ligand for the epidermal growth factor receptor. The Journal of biological chemistry 326 9988678
1992 Binding of the proteoglycan decorin to collagen type VI. The Journal of biological chemistry 302 1544908
2012 Decorin: a guardian from the matrix. The American journal of pathology 262 22735579
1988 Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Nature 254 3194009
1992 Transforming growth factor-beta complexes with thrombospondin. Molecular biology of the cell 242 1550960
1998 Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. The Journal of clinical investigation 236 9435313
2010 Proteomics characterization of extracellular space components in the human aorta. Molecular & cellular proteomics : MCP 231 20551380
2014 Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC cancer 203 25037231
2009 Decorin is a novel antagonistic ligand of the Met receptor. The Journal of cell biology 200 19433454
2002 Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. The Journal of biological chemistry 194 12105206
2017 Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. Journal of proteome research 185 28675934
2013 The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology 184 23978385
2006 Elastic fibres in health and disease. Expert reviews in molecular medicine 183 16893474
2005 The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature 156 15988528
2002 Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray. Biochemical and biophysical research communications 116 11820791
2021 DCN released from ferroptotic cells ignites AGER-dependent immune responses. Autophagy 105 34964698
1990 Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively. Genomics 60 1968422
1989 Recognition of (dG)n.(dC)n sequences by endonuclease G. Characterization of the calf thymus nuclease. The Journal of biological chemistry 53 2914952
2019 Identification of CAV1 and DCN as potential predictive biomarkers for lung adenocarcinoma. American journal of physiology. Lung cellular and molecular physiology 49 30604627
2021 lncRNA FDNCR promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep. Molecular therapy. Nucleic acids 45 33767918
1992 Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN). Cytogenetics and cell genetics 42 1611907
2007 Structural basis for the function of DCN-1 in protein Neddylation. The Journal of biological chemistry 41 17597076
2016 Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. Journal of cell science 40 26906416
2009 Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer. BMC cancer 36 19678923
1987 Structure of (dG)n.(dC)n under superhelical stress and acid pH. Journal of biomolecular structure & dynamics 36 3271474
2015 DCN deficiency promotes renal cell carcinoma growth and metastasis through downregulation of P21 and E-cadherin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 26547587
2017 Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D-LC-MS/MS Combined with iTRAQ Technology. Journal of Cancer 27 28261350
2018 Oncolytic Adenovirus rAd.DCN Inhibits Breast Tumor Growth and Lung Metastasis in an Immune-Competent Orthotopic Xenograft Model. Human gene therapy 24 30032645
1988 Deoxycytidine methylation does not affect DNA.RNA hybrid formation or B-A transitions of (dG)n.(dC)n sequences. Nucleic acids research 24 3368317
1989 Energetics of the B-H transition in supercoiled DNA carrying d(CT)x.d(AG)x and d(C)n.d(G)n inserts. Nucleic acids research 22 2587262
2019 RETRACTED: LSAMP-AS1 binds to microRNA-183-5p to suppress the progression of prostate cancer by up-regulating the tumor suppressor DCN. EBioMedicine 21 31727599
2010 Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. Investigative ophthalmology & visual science 21 20357198
2014 Methylated +58CpG site decreases DCN mRNA expression and enhances TGF-β/Smad signaling in NSCLC cells with high metastatic potential. International journal of oncology 20 24424784
2024 Tissue-targeted and localized AAV5-DCN and AAV5-PEDF combination gene therapy abrogates corneal fibrosis and concurrent neovascularization in rabbit eyes in vivo. The ocular surface 17 38191093
2024 Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling. Cells 15 38667295
2019 Differential expression of extracellular matrix‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis. Oncology reports 15 31524274
2018 Effects of transplanted adipose derived stem cells on the expressions of α-SMA and DCN in fibroblasts of hypertrophic scar tissues in rabbit ears. Experimental and therapeutic medicine 15 30186394
2016 NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 15 27162485
2005 The COPG2, DCN, and SDHD genes are biallelically expressed in cattle. Mammalian genome : official journal of the International Mammalian Genome Society 15 16151700
2024 The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas. Cancer metastasis reviews 14 38466528
2022 Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. Bioengineered 13 35420507
1991 A spectrotemporal analysis of DCN single unit responses to wideband noise in guinea pig. Hearing research 12 2066285
2024 Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis. Chemical biology & drug design 10 38230769
2012 OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. PloS one 9 22279542
2010 Expression and genomic imprinting of DCN, PON2 and PEG3 genes in porcine placenta. Animal reproduction science 9 21232885
2023 Sex differences in descending control of nociception (DCN) responses after chronic orofacial pain induction in rats and the contribution of kappa opioid receptors. Behavioural brain research 8 38036264
2010 Novel SNPs in the caprine stearoyl-CoA desaturase (SCD) and decorin (DCN) genes that are associated with growth traits in Chinese goat breeds. Molecular biology reports 8 20401695
2008 SDF-1/54-DCN: a novel recombinant chimera with dual inhibitory effects on proliferation and chemotaxis of tumor cells. Biological & pharmaceutical bulletin 7 18520035
2007 Autosomal dominant cornea plana is not associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2. Ophthalmic genetics 7 17558846
2024 Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells. Frontiers in cellular and infection microbiology 6 39145305
2023 Xinshubao tablet ameliorates myocardial injury against heart failure via the DCN/PPARα/PGC-1α/P300 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 6 37597320
2022 Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy. Cornea 4 36534610
1998 Intrinsic oscillations and discharge regularity of units in the dorsal cochlear nucleus (DCN) of the barbiturate anesthetized gerbil. Annals of biomedical engineering 4 9570230
2023 Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum. International journal of molecular sciences 3 36675230
2022 Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN. Neural plasticity 3 36452876
2023 A pediatric case of congenital stromal corneal dystrophy caused by the novel variant c.953del of the DCN gene. Human genome variation 2 36964172
2025 Identification and quantification of GABAA R-α1-positive cells in the DCN of rats with behavioral evidence of noise-induced tinnitus. IBRO neuroscience reports 1 40791738
2024 Expression and secretion of SPARC, FGF-21 and DCN in bovine muscle cells: Effects of age and differentiation. PloS one 1 38959242
2019 Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell - DCN Synapse. Frontiers in synaptic neuroscience 1 31824291
2016 [Influences of human dermis derived mesenchymal stem cells on α-SMA and DCN expressions of hypertrophic scars fibroblasts]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 1 30044575
2026 DCN-type NEDD8 E3 ligases: Structure, biological function and small-molecule inhibitor. Pharmacological research 0 41730487
2026 DCN promotes dermal papilla cells proliferation by escaping chi-miR-497-5p mediated repression via circPIEZO2 sponging. Cellular signalling 0 41966438
2026 A Conserved Fibroblast-Myeloid Gene Signature in Digestive Cancers: Multi-Omics Integration Identifies DCN, COL10A1, CTHRC1, and TREM2 as Candidate Microenvironmental Markers. International journal of molecular sciences 0 41977392
2025 Protein interaction network drive more group integrated analytic larynx hub protein markers: LYVE1/FBLN5/INMT/DCN/ZFY/RSPO3 protein macromolecule collaborative diagnosis of a new era. International journal of biological macromolecules 0 40419046
2025 EGR3 Transcriptionally Upregulates the Expression of DCN in Liver Cancer to Inhibit Tumor Progression. Journal of biochemical and molecular toxicology 0 40660758
2025 lncRNA PAX8-AS1 suppresses cervical cancer development by regulating miR-675-3p/DCN axis. The International journal of biological markers 0 41148053
2025 DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma. Journal of cancer research and clinical oncology 0 41205056
2025 A Novel Strategy for Optimized Achilles Tendon Healing: DCN/Hep-Loaded Sutures. Journal of biomedical materials research. Part A 0 41313163
2025 Curcumin alleviates the effects of heat stress on broiler pectoral muscle via decorin (DCN) -mediated TGF-β Signaling pathway. Poultry science 0 41418534
2025 Dcn/HIF1A axis modulates proliferation, apoptosis, oxidative stress and autophagy in liver regeneration. International immunopharmacology 0 41468793