Affinage

DAZAP1

DAZ-associated protein 1 · UniProt Q96EP5

Length
407 aa
Mass
43.4 kDa
Annotated
2026-04-28
30 papers in source corpus 26 papers cited in narrative 26 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAZAP1 is a nucleocytoplasmic-shuttling hnRNP protein that functions as a pleiotropic post-transcriptional regulator of gene expression through alternative splicing, mRNA stabilization, and translational control. It promotes inclusion of weak exons by binding intronic regulatory elements and using its C-terminal proline-rich domain to neutralize splicing inhibitors; this splicing activity requires MEK/ERK-dependent phosphorylation at Thr269 and Thr315, which also governs its nuclear–cytoplasmic distribution and dissociation from the germ-cell factor DAZ (PMID:24452013, PMID:16848763). DAZAP1 stabilizes specific mRNAs—including SLC7A11, USP34, NOTCH1, and JAG1—by binding their 3′-UTRs and acts as an mRNA-specific translational activator that stimulates cap-independent initiation (PMID:21576381, PMID:33358859, PMID:41789621). Loss of DAZAP1 in mice causes spermatogenic arrest before meiotic division, growth retardation, and female infertility, underscoring its essential role in gametogenesis and somatic cell proliferation (PMID:18669443).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2001 Medium

    Identifying DAZAP1 as a DAZ/DAZL-interacting RNA-binding protein established its molecular identity and linked it to germ cell biology.

    Evidence Yeast two-hybrid and in vitro binding with DAZ/DAZL; domain mapping revealed two RBDs and a proline-rich C-terminus

    PMID:11604102

    Open questions at the time
    • No endogenous function demonstrated
    • RNA targets unknown
    • Interaction with DAZ not validated in vivo
  2. 2006 High

    Discovery that DAZAP1 is an hnRNP component that shuttles between nucleus and cytoplasm via a C-terminal signal, dependent on active transcription, defined its subcellular dynamics and placed it among spliceosome-associated factors.

    Evidence Heterokaryon assay, actinomycin D treatment, GFP-fusion mutagenesis identifying a 25-aa nuclear-shuttling signal; co-localization with hnRNP A1/C1

    PMID:16772659

    Open questions at the time
    • Cargo RNA identity during shuttling unknown
    • Whether shuttling is regulated by signaling not addressed
  3. 2006 High

    Demonstrating ERK2-mediated phosphorylation at Thr269/Thr315 that controls DAZ dissociation connected DAZAP1 to MAPK signaling and suggested a regulatory switch for its activity.

    Evidence In vitro kinase assay with ERK2, phospho-mimetic mutants, MEK inhibitors (PD184352, U0126), co-immunoprecipitation showing phosphorylation-dependent DAZ release

    PMID:16848763

    Open questions at the time
    • In vivo phosphorylation kinetics uncharacterized
    • Downstream consequences of DAZ dissociation on RNA metabolism unknown
  4. 2008 High

    Genetic loss-of-function in mice proved DAZAP1 is essential for spermatogenesis and normal growth, establishing it as a non-redundant regulator of germ cell development.

    Evidence Knockout/hypomorphic mouse models with FACS, histology, and immunostaining showing pre-meiotic spermatogenic arrest and growth retardation

    PMID:18669443

    Open questions at the time
    • Molecular targets responsible for meiotic arrest not identified
    • Female infertility mechanism not resolved
  5. 2008 High

    Identification of DAZAP1 binding to a BRCA1 exonic splicing silencer provided the first direct evidence for its role in splicing regulation.

    Evidence RNA pulldown, siRNA knockdown, and minigene reporter for BRCA1 exon 18 skipping

    PMID:18391021

    Open questions at the time
    • Genome-wide splicing targets unknown
    • Whether DAZAP1 is activator or repressor in general context unclear
  6. 2011 High

    Reconstitution of DAZAP1's translational activity showed it stimulates cap-independent translation initiation, expanding its functions beyond splicing to translational control.

    Evidence In vitro translation with reporter mRNAs, IRES constructs, domain mapping showing C-terminal activity, polysome association

    PMID:21576381

    Open questions at the time
    • In vivo translational targets not identified
    • Mechanism of cap-independent stimulation not structurally resolved
  7. 2013 High

    Combining Dazap1-mutant transcriptomics with minigene reporters demonstrated that DAZAP1 promotes weak exon inclusion by binding downstream intronic elements, defining its general splicing-activation mechanism.

    Evidence Exon microarray on mutant mouse testes identifying Crem, Crisp2, Pot1a targets; minigene reporters; RNA-binding assays with mutant proteins

    PMID:23965306

    Open questions at the time
    • Full RNA binding motif not defined
    • How intronic binding leads to exon recognition mechanistically unclear
  8. 2014 High

    Tethering and domain-mapping experiments showed the proline-rich domain neutralizes splicing inhibitors and that MEK/ERK phosphorylation of this domain is essential for splicing activity and nuclear localization, unifying signaling control with splicing mechanism.

    Evidence MS2-tethering assay, domain mutagenesis, MEK inhibitor treatment, mRNA-seq, cell proliferation assays

    PMID:24452013

    Open questions at the time
    • Identity of neutralized splicing inhibitors at molecular level unknown
    • Structural basis of proline-rich domain function unresolved
  9. 2020 High

    DAZAP1-dependent alternative splicing of TSC2 controlling mTOR/autophagy signaling revealed how a single splicing event by DAZAP1 rewires an entire signaling pathway.

    Evidence RNA-seq, minigene, AKT phosphorylation and mTOR pathway analysis in ESCC cells with DAZAP1 silencing

    PMID:32308763

    Open questions at the time
    • Whether TSC2 splicing regulation is direct or indirect not fully resolved
    • Generality across cell types untested
  10. 2020 Medium

    Showing DAZAP1 stabilizes SLC7A11 mRNA via 3′-UTR binding to inhibit ferroptosis established a direct mRNA stabilization function with disease relevance beyond splicing.

    Evidence RIP, siRNA knockdown, mRNA stability and ferroptosis assays in HCC cells

    PMID:33358859

    Open questions at the time
    • Binding site on SLC7A11 3′-UTR not mapped
    • Mechanism of stabilization (deadenylase blockade vs. other) unknown
  11. 2024 Medium

    Discovery of DAZAP1 liquid–liquid phase separation as a mechanism for its nuclear concentration and splicing regulation introduced a biophysical dimension to its function.

    Evidence In vitro and cellular phase separation assays, RNA-seq showing COX16 splicing regulation, Seahorse metabolic assay in OSCC

    PMID:39120588

    Open questions at the time
    • Phase separation determinants (IDR residues) not mapped
    • Whether phase separation is regulated by ERK phosphorylation untested
    • Single cancer type studied
  12. 2025 Medium

    Multiple studies converged to show DAZAP1 stabilizes diverse oncogenic mRNAs (USP34, NOTCH1, JAG1) and is itself regulated by ALKBH5-mediated m6A demethylation, embedding DAZAP1 in epitranscriptomic and oncogenic signaling networks.

    Evidence RIP-seq, mRNA stability assays, m6A detection, ubiquitination assays, xenograft models in gastric and colorectal cancer

    PMID:40486833 PMID:41331184 PMID:41789621

    Open questions at the time
    • Genome-wide map of DAZAP1-stabilized mRNAs not available
    • Relative contribution of splicing vs. stability functions in cancer unclear
    • No structural basis for 3′-UTR recognition

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of DAZAP1's RNA recognition specificity, the full catalog of its RNA targets across tissues, how phase separation intersects with ERK-dependent phosphorylation, and whether its splicing and stability functions are coordinated or independently regulated.
  • No crystal or cryo-EM structure available
  • No CLIP-seq or eCLIP binding map across cell types
  • Relationship between phase separation and phosphorylation untested
  • Relative importance of splicing vs. mRNA stability in germ cells unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 10 GO:0140098 catalytic activity, acting on RNA 7 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 4 GO:0005654 nucleoplasm 3 GO:0005829 cytosol 3
Pathway
R-HSA-8953854 Metabolism of RNA 7 R-HSA-392499 Metabolism of proteins 5 R-HSA-162582 Signal Transduction 4 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1474165 Reproduction 2 R-HSA-9612973 Autophagy 2
Partners
DAZDAZLERK2HNRNPA1PXRSLIRP
Complex memberships
hnRNP particlesparaspeckles

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 DAZAP1 was identified as a protein that interacts with the male infertility factors DAZ and DAZL through yeast two-hybrid and in vitro binding assays; it contains two RNA-binding domains (RBDs) and a proline-rich C-terminal region, and while predominantly cytoplasmic, it is not associated with polyribosomes. Yeast two-hybrid, in vitro binding, subcellular fractionation, Western blot BMC genomics Medium 11604102
2004 Mouse DAZAP1/Prrp shows dynamic intranuclear and subcellular localization changes during spermatogenesis (nuclear in pre-meiotic cells and round spermatids, cytoplasmic in elongating spermatids), and the C-terminal proline-rich region is required for nuclear import. Immunohistochemistry with monoclonal antibody, mutagenesis, subcellular localization assays Archives of histology and cytology Medium 15700540
2005 DAZAP1 interacts with DAZL protein in ovarian luteal cells as demonstrated by co-immunoprecipitation from ovarian tissue. Co-immunoprecipitation from rat and human ovarian tissue Fertility and sterility Low 16209998
2005 The MEF2D/DAZAP1 fusion protein (created by t(1;19) translocation) binds DNA in a manner indistinguishable from native MEF2D and acts as a substantially more potent transcriptional activator than MEF2D; the reciprocal DAZAP1/MEF2D fusion retains sequence-specific RNA-binding activity. DNA-binding assays, transcriptional activation assays, RNA-binding assays in leukemia cell line Leukemia Medium 15744350
2006 DAZAP1 is phosphorylated by ERK2 at two Thr-Pro sequences (Thr269 and Thr315) in response to PMA, EGF, or LPS via the MKK1/ERK pathway; phosphorylation at these sites causes DAZAP1 to dissociate from its binding partner DAZ, and DAZ cannot simultaneously bind both DAZAP1 and PABP. In vitro kinase assay with ERK2, site-directed mutagenesis (T269D, T315D), co-immunoprecipitation, inhibitor experiments (PD184352, U0126) The Biochemical journal High 16848763
2006 DAZAP1 shuttles between the nucleus and cytoplasm via a novel 25-amino acid C-terminal segment (ZNS); nuclear localization depends on active RNA polymerase II transcription; DAZAP1 co-localizes with hnRNP A1 and hnRNP C1 and is a component of hnRNP particles. Immunostaining, heterokaryon formation assay, mutagenesis, RNA polymerase II inhibitor (actinomycin D), GFP/DsRed fusion constructs RNA (New York, N.Y.) High 16772659
2007 Both MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins transform NIH 3T3 cells (soft agar colony formation); co-expression is synergistic; wild-type DAZAP1 expression enables 3T3 cell proliferation under low serum and suppresses apoptosis. Retroviral gene transfer, soft agar colony formation assay, low-serum proliferation assay, apoptosis assay Leukemia Medium 17898785
2008 DAZAP1 binds to a T6 mutant BRCA1 exon 18 sequence that creates an exonic splicing silencer, and siRNA depletion of DAZAP1 reduces skipping of exon 18, demonstrating DAZAP1's role in splicing inhibition at this element alongside hnRNPA1/A2. RNA pulldown assay, siRNA knockdown, minigene splicing reporter, overexpression Molecular and cellular biology High 18391021
2008 DAZAP1 is an hnRNP protein required for normal growth and spermatogenesis in mice; loss-of-function causes spermatogenic arrest before meiotic division (absence of post-meiotic haploid cells), growth retardation, and female infertility; DAZAP1 is excluded from the transcriptionally inactive XY body in pachytene spermatocytes. Knockout/hypomorphic mouse models, FACS analysis, histology, immunostaining RNA (New York, N.Y.) High 18669443
2009 DAZAP1 interacts with several RNA-binding proteins (beyond DAZ) via its RNA recognition motifs (RRMs) binding to the C-termini of these partners, in a phosphorylation-independent manner, suggesting DAZAP1 is part of complexes involved in mRNA degradation and silencing. Co-immunoprecipitation, binding domain mapping Biochemical and biophysical research communications Low 19285026
2011 DAZAP1 (Xenopus and human) acts as a mRNA-specific translational activator by stimulating translation initiation in a cap-independent manner downstream of 5' cap recognition; this activity is modulated by poly(A) tail length and is associated with formation of end-to-end mRNA complexes but does not require direct interaction with eIF4G; domain mapping places this activity in C-terminal regions. In vitro translation assay with reporter mRNAs, IRES constructs, domain mapping/mutagenesis, polysome association assays RNA (New York, N.Y.) High 21576381
2011 DAZAP1 binds to an Alu-derived intronic splicing enhancer (ISE) in the ATM gene and positively regulates ISE-dependent inclusion of an ATM cryptic exon, as demonstrated by RNA pulldown and siRNA functional experiments. RNA pulldown assay, siRNA knockdown, overexpression, minigene splicing assay PloS one Medium 21858080
2012 A 42-amino acid N-terminal segment (N42) of DAZAP1 is necessary and sufficient for its transcription-dependent nuclear localization; SLIRP was identified as an N42-binding protein that may regulate DAZAP1 subcellular localization. Domain deletion/mutagenesis, immunostaining, yeast two-hybrid Biochemical and biophysical research communications Medium 23111326
2013 DAZAP1 promotes inclusion of specific exons (Crem exon 4, Crisp2 exon 9, Pot1a exon 4) by binding to regulatory sequences in their downstream introns, as demonstrated in DAZAP1-deficient mouse testes (microarray) and splicing reporter assays; DAZAP1 mutant proteins lacking this activity fail to rescue exon inclusion. Exon microarray on Dazap1 mutant testes, minigene splicing reporters, RNA-binding assays, mutagenesis Nucleic acids research High 23965306
2013 The two Dazap1 transcripts (generated by alternative polyadenylation) are differentially translated during spermatogenesis; DAZL binds preferentially to the 3'UTR of the long Dazap1-L transcript and stimulates its translation; the short Dazap1-S is translationally repressed and sequestered to mRNPs with elongated poly(A) tails. Northern blot, 3' RACE, sucrose gradient/polysome analysis, RNA pulldown + mass spectrometry, luciferase reporter assay PloS one High 23658607
2014 DAZAP1 promotes inclusion of weak exons by recognizing diverse cis-elements; its C-terminal proline-rich domain interacts with and neutralizes general splicing inhibitors and is sufficient to activate splicing when tethered to pre-mRNA; MEK/ERK phosphorylation of this domain is essential for splicing regulatory activity and controls nuclear/cytoplasmic translocation of DAZAP1; DAZAP1 regulates endogenous splicing events involved in cell growth, and its knockdown or overexpression causes a cell proliferation defect. Minigene splicing reporters, domain mapping/mutagenesis, tethering assay, MEK/ERK inhibitor experiments, mRNA-seq, siRNA knockdown, overexpression, cell proliferation assays Nature communications High 24452013
2018 DAZAP1 binds to cox6c mRNA in an intron-dependent manner (last intron sufficient for loading), reduces pre-mRNA splicing efficiency, and thereby negatively regulates COX6C protein levels; overexpression of DAZAP1 leads to accumulation of cox6c pre-mRNA. RIP (RNA immunoprecipitation), intron deletion constructs, qRT-PCR, Western blot, overexpression Gene Medium 29505834
2020 DAZAP1 binds to the 3'UTR of SLC7A11 mRNA and positively regulates its stability, thereby inhibiting ferroptosis in HCC cells; DAZAP1 knockdown reduces SLC7A11 levels and sensitizes cells to sorafenib-induced ferroptosis. RNA immunoprecipitation (RIP), siRNA knockdown, mRNA stability assay, ferroptosis assays, Western blot Experimental cell research Medium 33358859
2020 DAZAP1 regulates alternative splicing of TSC2, promoting inclusion of exon 26; DAZAP1 silencing produces a short TSC2 isoform that cannot be phosphorylated at Ser981 by AKT, leading to constitutive TSC2 activation, RHEB-mediated mTOR inhibition, and enhanced autophagy in ESCC cells; miR-10b suppresses DAZAP1 expression under starvation. RNAseq, siRNA knockdown, minigene splicing, AKT phosphorylation assay, mTOR pathway analysis, miR-10b overexpression Theranostics High 32308763
2022 DAZAP1 activates alternative splicing of KITLG mRNA, and the resulting KITLG isoform increases ERK phosphorylation to promote multiple myeloma cell proliferation. RIP-seq, RIP-qPCR, lentiviral overexpression, siRNA knockdown, ERK phosphorylation assay, xenograft tumor model Aging Medium 36242590
2023 DAZAP1 interacts with PXR (pregnane X receptor) and with the lncRNA NEAT1_2 as a paraspeckle component; this interaction traps PXR in paraspeckles and suppresses its transactivation of CYP3A4; PXR ligand (rifampicin) dissociates PXR from DAZAP1 and NEAT1_2, and knockdown of DAZAP1 enhances CYP3A4 induction by rifampicin. Co-immunoprecipitation, siRNA knockdown, luciferase reporter assay (PXR response elements) Drug metabolism and disposition Medium 37349114
2024 DAZAP1 undergoes liquid-liquid phase separation to accumulate in the nucleus where it regulates alternative splicing of COX16 pre-mRNA, increasing COX16 expression and promoting mitochondrial respiration and OSCC invasion/metastasis. Phase separation assay, RNA-seq, splicing reporter, DAZAP1 knockdown/overexpression, Seahorse metabolic assay, mouse tumor model Cancer research Medium 39120588
2025 p52-ZER6 promotes transcriptional activity of DAZAP1, which then binds the 3'-UTR of SLC7A11 mRNA to enhance its stability, increasing SLC7A11 protein, elevating glutathione levels, reducing lipid peroxide accumulation, and conferring ferroptosis resistance in colorectal cancer. Transcription reporter assay, RNA immunoprecipitation, mRNA stability assay, ferroptosis assays (lipid peroxide, GSH), knockdown/overexpression Acta pharmaceutica Sinica. B Medium 40486833
2025 DAZAP1 binds USP34 mRNA and stabilizes it, leading to increased USP34 protein expression, which mediates deubiquitination and stabilization of PIN1 oncoprotein, activating the MAPK signaling pathway in gastric cancer; DAZAP1 mRNA is itself post-transcriptionally stabilized by the m6A demethylase ALKBH5, protecting it from YTHDF2-mediated degradation. RNA immunoprecipitation, mRNA stability assay, co-immunoprecipitation, ubiquitination assay, m6A detection, siRNA/overexpression, in vivo xenograft Cell biology and toxicology Medium 41331184
2025 DAZAP1 regulates splicing and expression of the mitophagy-related gene ULK1 through nonsense-mediated mRNA decay, thereby activating mitophagy and enhancing oxidative phosphorylation to support gastric cancer stem cell maintenance. RNA immunoprecipitation, PCR-based splicing analysis, Seahorse assay, sphere formation assay, transmission electron microscopy, immunofluorescence, rescue experiments (ULK1 overexpression) JCI insight Medium 40401521
2026 DAZAP1 physically binds NOTCH1 and JAG1 mRNAs to enhance their stability, activating the NOTCH/JAG1 signaling pathway and promoting EMT-mediated migration and invasion of gastric cancer cells. RNA immunoprecipitation (RIP-seq and RIP-qPCR), mRNA stability assay, knockdown/overexpression, migration/invasion assays International journal of oncology Medium 41789621

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA. Experimental cell research 79 33358859
2008 Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. Molecular and cellular biology 71 18391021
2014 The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration. Nature communications 51 24452013
2005 Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. Leukemia 47 15744350
2008 DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. RNA (New York, N.Y.) 42 18669443
2011 DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation. RNA (New York, N.Y.) 41 21576381
2006 A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein. RNA (New York, N.Y.) 40 16772659
2020 Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma. Theranostics 33 32308763
2007 Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia. Leukemia 30 17898785
2011 Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. PloS one 27 21858080
2001 Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. BMC genomics 27 11604102
2006 Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. The Biochemical journal 26 16848763
2009 DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. Biochemical and biophysical research communications 20 19285026
2024 DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma. Cancer research 19 39120588
2013 DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts. Nucleic acids research 19 23965306
2018 Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation. Gene 13 29505834
2004 Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Archives of histology and cytology 13 15700540
2023 MiR-320a upregulation improves IL-1β-induced osteoarthritis via targeting the DAZAP1 and MAPK pathways. Journal of orthopaedic surgery and research 10 37507717
2013 Differential translation of Dazap1 transcripts during spermatogenesis. PloS one 10 23658607
2005 Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. Fertility and sterility 10 16209998
2022 DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway. Aging 9 36242590
2022 DAZAP1 overexpression promotes growth of HCC cell lines: a primary study using CEUS. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 8 35091997
2025 p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization. Acta pharmaceutica Sinica. B 7 40486833
2023 NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction. Drug metabolism and disposition: the biological fate of chemicals 5 37349114
2025 DAZAP1 maintains gastric cancer stemness by inducing mitophagy. JCI insight 3 40401521
2012 Transcription-dependent nuclear localization of DAZAP1 requires an N-terminal signal. Biochemical and biophysical research communications 3 23111326
2025 RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis. European journal of medical research 1 39754243
2025 An integrated analysis of second- and third-generation transcriptome sequencing technologies reveals the DAZAP1 function in pig testis. Animal reproduction 1 40584277
2026 RNA‑binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability. International journal of oncology 0 41789621
2025 DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer. Cell biology and toxicology 0 41331184