Affinage

DAZAP1

DAZ-associated protein 1 · UniProt Q96EP5

Length
407 aa
Mass
43.4 kDa
Annotated
2026-06-09
30 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAZAP1 is an evolutionarily conserved hnRNP-type RNA-binding protein that acts as a splicing activator and post-transcriptional regulator, controlling exon usage and mRNA fate during spermatogenesis and cell growth (PMID:18669443, PMID:24452013). It carries two N-terminal RNA recognition motifs that bind diverse cis-elements—including exonic splicing silencers, Alu-derived intronic splicing enhancers, and intronic regions flanking weak exons—and a C-terminal proline-rich domain that, when tethered to pre-mRNA, is sufficient to activate splicing by interacting with and neutralizing general splicing inhibitors, thereby promoting inclusion of weak exons (PMID:18391021, PMID:21858080, PMID:23965306, PMID:24452013). DAZAP1 shuttles between nucleus and cytoplasm through a novel C-terminal segment (ZNS) and an N-terminal N42 segment, with nuclear localization dependent on active RNA Pol II transcription, where it colocalizes with hnRNP A1 and C1 in hnRNP particles (PMID:16772659, PMID:23111326). The MEK/ERK pathway phosphorylates the C-terminal domain at Thr269 and Thr315; this phosphorylation is essential for splicing activity and nuclear/cytoplasmic translocation, and dissociates DAZAP1 from its original partner DAZ, freeing DAZ to engage PABP and stimulate translation (PMID:16848763, PMID:24452013). Beyond splicing, DAZAP1 itself activates translation initiation in a 3'UTR-binding-site-number-dependent, cap-independent but poly(A)-sensitive manner, consistent with promoting end-to-end mRNA complex formation (PMID:21576381), and stabilizes specific target mRNAs through 3'UTR binding—including SLC7A11 to suppress ferroptosis and USP34 and NOTCH1/JAG1 to drive tumor signaling (PMID:33358859, PMID:40486833, PMID:41331184, PMID:41789621). DAZAP1 concentrates its nuclear splicing activity via liquid-liquid phase separation (PMID:39120588). In vivo, mouse knockout and hypomorphic alleles cause growth retardation and spermatogenic arrest before meiosis, establishing essential roles in development and germ cell differentiation (PMID:18669443).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2001 Medium

    Established DAZAP1 as a DAZ/DAZL-interacting protein with a modular architecture, framing it as a candidate regulator of germ-cell mRNA metabolism.

    Evidence Yeast two-hybrid, Western blot, and subcellular fractionation identifying two RBDs and a proline-rich C-terminus

    PMID:11604102

    Open questions at the time
    • RNA targets undefined
    • Functional consequence of DAZ binding not tested
    • Cytoplasmic predominance not mechanistically explained
  2. 2006 High

    Defined how DAZAP1 traffics between compartments, showing a novel ZNS shuttling signal and transcription-coupled nuclear residence within hnRNP particles.

    Evidence Heterokaryon assay, mutagenesis, RNA Pol II inhibitor treatment, and colocalization with hnRNP A1/C1

    PMID:16772659

    Open questions at the time
    • Import/export receptors for ZNS unidentified
    • Link between transcription dependence and splicing function not yet established
  3. 2006 High

    Connected DAZAP1 to ERK signaling and revealed phosphorylation as a switch that releases DAZ to engage the translation machinery.

    Evidence In vitro ERK2 kinase assay, mass spectrometry, phosphomimetic mutagenesis, and Co-IP in HEK293 and macrophages

    PMID:16848763

    Open questions at the time
    • Whether phosphorylation alters DAZAP1's own RNA binding not addressed here
    • In vivo physiological trigger of ERK input unclear
  4. 2008 High

    Demonstrated DAZAP1 is genetically required for mammalian development and meiotic progression in spermatogenesis.

    Evidence Mouse knockout/hypomorphic alleles with FACS and immunostaining showing pre-meiotic arrest

    PMID:18669443

    Open questions at the time
    • Molecular target mRNAs driving the phenotype not identified in this study
    • Tissue-specific vs systemic contributions unresolved
  5. 2008 High

    Provided direct evidence that DAZAP1 acts on splicing by binding an exonic splicing silencer to enforce exon skipping.

    Evidence RNA pulldown, siRNA depletion, and minigene reporter on a mutant BRCA1 exon 18 element

    PMID:18391021

    Open questions at the time
    • Generality of silencer vs enhancer behavior not yet defined
    • Co-factors mediating skipping unknown
  6. 2011 High

    Revealed a direct translational activation function distinct from splicing, mapped to the C-terminus and dependent on 3'UTR site number and poly(A) status.

    Evidence In vitro translation, IRES reporters, polysome fractionation, and Xenopus oocyte injection

    PMID:21576381

    Open questions at the time
    • Bridging factor for end-to-end complex unidentified (not eIF4G)
    • Endogenous mRNA targets of this activity unspecified
  7. 2011 Medium

    Showed DAZAP1 can act as a positive splicing regulator through intronic splicing enhancers, broadening its element repertoire.

    Evidence RNA pulldown and siRNA knockdown on an Alu-derived ATM ISE with splicing reporter

    PMID:21858080

    Open questions at the time
    • Mechanism reconciling silencer (BRCA1) and enhancer (ATM) outcomes not resolved
    • Direct vs indirect binding to ISE in vivo not confirmed
  8. 2013 High

    Identified physiological in vivo splicing targets in testes, linking DAZAP1-dependent exon inclusion to the growth and germ-cell phenotypes.

    Evidence Microarray exon profiling of mutant vs WT testes, minigene reporters, and binding assays for Crem, Crisp2, and Pot1a

    PMID:23965306

    Open questions at the time
    • Whether Pot1a misregulation is sufficient for growth retardation not proven
    • Full in vivo target set incomplete
  9. 2014 High

    Integrated the mechanism by showing the proline-rich C-terminus neutralizes general splicing inhibitors and that MEK/ERK phosphorylation is essential for splicing activity and shuttling.

    Evidence mRNA-seq, tethering assay, phosphomutant analysis, MEK/Erk inhibitors, and proliferation assays

    PMID:24452013

    Open questions at the time
    • Identity of the neutralized splicing inhibitors not fully enumerated
    • Direct structural basis of inhibitor neutralization unknown
  10. 2024 Medium

    Showed liquid-liquid phase separation as the biophysical basis for concentrating DAZAP1 splicing activity in the nucleus.

    Evidence LLPS assay with RNA-seq, knockdown/overexpression, and OSCC mouse model

    PMID:39120588

    Open questions at the time
    • Domains/residues driving phase separation not mapped
    • Relationship between LLPS and ERK phosphorylation untested
  11. 2025 Medium

    Extended DAZAP1's role to 3'UTR-mediated mRNA stabilization across cancers, controlling ferroptosis resistance and oncogenic signaling.

    Evidence RIP, mRNA stability assays, and functional readouts for SLC7A11, USP34/PIN1/MAPK, and NOTCH1/JAG1 targets

    PMID:33358859 PMID:40486833 PMID:41331184 PMID:41789621

    Open questions at the time
    • Binding-site definitions within 3'UTRs incomplete
    • Mechanism of stabilization (decay factor displacement) not resolved
    • NOTCH1/JAG1 link rests on a single low-confidence study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DAZAP1 selects between splicing activation, mRNA stabilization, and translational control on a given transcript, and how phosphorylation and phase separation coordinate these outputs, remains unresolved.
  • No unified model linking RRM target choice to functional outcome
  • Structural basis of inhibitor neutralization and LLPS unmapped
  • Direct nuclear import/export machinery for ZNS/N42 unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0140110 transcription regulator activity 4 GO:0098772 molecular function regulator activity 3 GO:0045182 translation regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2
Pathway
R-HSA-8953854 Metabolism of RNA 5 R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1474165 Reproduction 2
Partners
DAZDAZLHNRNP A1HNRNP C1PABPPXRSLIRP
Complex memberships
hnRNP particleparaspeckle

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 DAZAP1 was originally identified as an interaction partner of DAZ and DAZL via yeast two-hybrid; DAZAP1 contains two RNA-binding domains (RBDs) and a proline-rich C-terminal region; in subcellular fractionation, the majority of DAZAP1 is present in the cytoplasmic fraction but not associated with polyribosomes. Yeast two-hybrid, Western blot, subcellular fractionation BMC genomics Medium 11604102
2004 Mouse DAZAP1 (mPrrp) undergoes dynamic intranuclear and subcellular localization changes during spermatogenesis; a long stretch spanning the C-terminal half of the protein is required for nuclear import. Immunohistochemistry with monoclonal antibody, mutagenesis, subcellular localization analysis Archives of histology and cytology Medium 15700540
2005 DAZAP1/MEF2D fusion protein retains sequence-specific RNA-binding activity; MEF2D/DAZAP1 fusion binds DNA in a manner indistinguishable from native MEF2D and is a more potent transcriptional activator than MEF2D. DNA-binding assay, transcriptional activation assay, leukemia cell line analysis Leukemia Medium 15744350
2005 DAZAP1 is expressed in ovarian luteal cells and co-immunoprecipitates with DAZL in ovarian tissue, demonstrating an in vivo interaction. Co-immunoprecipitation, Western blot, immunohistochemistry Fertility and sterility Low 16209998
2006 DAZAP1 shuttles between the nucleus and cytoplasm via a novel 25 amino acid C-terminal segment (ZNS) that shares no homology with known nuclear localization or export signals; nuclear localization of DAZAP1 is dependent on active RNA Pol II transcription, as its inhibition retains DAZAP1 in the cytoplasm; DAZAP1 colocalizes with hnRNP A1 and hnRNP C1 in the nucleus as part of hnRNP particles. Immunostaining, heterokaryon formation assay, mutagenesis, RNA Pol II inhibitor treatment RNA (New York, N.Y.) High 16772659
2006 ERK2 phosphorylates DAZAP1 at Thr269 and Thr315 in vitro and in cells; this phosphorylation induces dissociation of DAZAP1 from DAZ; DAZ cannot bind simultaneously to both DAZAP1 and PABP, suggesting phosphorylation-driven DAZAP1 release allows DAZ to interact with PABP and stimulate translation. In vitro kinase assay, mass spectrometry, site-directed mutagenesis (Thr→Asp), co-immunoprecipitation in HEK-293 cells and RAW 264.7 macrophages The Biochemical journal High 16848763
2007 Both MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins transform NIH 3T3 cells (~20-fold increase in soft agar colony formation); co-expression of both fusion proteins is synergistic; wild-type DAZAP1 expression allows proliferation under low-serum conditions and suppresses apoptosis. Retroviral gene transfer, soft agar colony formation assay, low-serum proliferation assay, apoptosis assay Leukemia Medium 17898785
2008 DAZAP1 binds to a mutant BRCA1 exon 18 sequence created by a G-to-T transversion (+6 position) via RNA pulldown; siRNA-mediated depletion of DAZAP1 rescues exon 18 inclusion, demonstrating that DAZAP1 binding to this exonic splicing silencer causes exon skipping. RNA pulldown assay, siRNA knockdown, minigene splicing reporter, mutation analysis Molecular and cellular biology High 18391021
2008 DAZAP1 is required for normal mouse development and spermatogenesis; null or hypomorphic Dazap1 mice show growth retardation and spermatogenic arrest before meiotic division (absence of haploid cells by FACS); DAZAP1 localizes to the nucleus excluding the XY body in pachytene spermatocytes, consistent with a role in mRNA transcription and transport. Mouse knockout/hypomorphic allele generation, FACS analysis, immunostaining RNA (New York, N.Y.) High 18669443
2009 DAZAP1's RNA recognition motifs (RRMs) interact with the C-termini of multiple other RNA-binding proteins (beyond DAZ) in a phosphorylation-independent manner, suggesting DAZAP1 is part of mRNA degradation/silencing complexes in non-germinal cells. Co-immunoprecipitation, domain-mapping pulldown Biochemical and biophysical research communications Low 19285026
2011 DAZAP1 (both Xenopus and human) acts as an mRNA-specific activator of translation initiation in a 3'UTR binding-site-number-dependent manner; this activity maps to the C-terminal region; DAZAP1 stimulates translation independently of 5'-cap recognition but is modulated by poly(A) tail status, suggesting a function in end-to-end mRNA complex formation; this activity does not require direct interaction with eIF4G. In vitro translation assay, IRES reporter mRNA assay, domain mapping, polysome fractionation, Xenopus oocyte injection RNA (New York, N.Y.) High 21576381
2011 DAZAP1 binds to an Alu-derived intronic splicing enhancer (ISE) in the ATM gene (shown by RNA pulldown); siRNA-mediated knockdown of DAZAP1 reduces ATM cryptic exon activation, demonstrating that DAZAP1 positively promotes ISE-dependent cryptic exon inclusion. RNA pulldown assay, siRNA knockdown, splicing reporter assay PloS one Medium 21858080
2012 An N-terminal 42 amino acid segment (N42) of DAZAP1 is necessary and sufficient for transcription-dependent nuclear localization; SLIRP was identified as an N42-binding protein via yeast two-hybrid, potentially regulating DAZAP1 subcellular localization. Mutagenesis, nuclear localization assay, yeast two-hybrid Biochemical and biophysical research communications Medium 23111326
2013 DAZAP1 promotes inclusion of Crem exon 4, Crisp2 exon 9, and Pot1a exon 4 in vivo in mouse testes; DAZAP1 binds intronic regions flanking these exons (Crem intron 3, Crisp2 intron 9, Pot1a intron 4) to regulate splicing; aberrant Pot1a splicing may account for the growth retardation in DAZAP1-deficient mice. Microarray exon-usage profiling of mutant vs. wild-type testes, minigene splicing reporters, DAZAP1 binding assays, mutagenesis Nucleic acids research High 23965306
2013 DAZL binds specifically to the 3'UTR of the Dazap1-L transcript and stimulates its translation; the two Dazap1 transcripts (generated by alternative polyadenylation) are differentially regulated, with the Dazap1-S transcript undergoing translational repression associated with poly(A) tail elongation during spermatogenesis. RNA pulldown followed by mass spectrometry, sucrose gradient fractionation, Northern blot, 3' RACE, reporter gene assay PloS one Medium 23658607
2014 DAZAP1 promotes inclusion of weak exons by recognizing diverse cis-elements; its C-terminal proline-rich domain interacts with and neutralizes general splicing inhibitors, is sufficient to activate splicing when tethered to pre-mRNA, and is phosphorylated by the MEK/Erk pathway; this phosphorylation is essential for both splicing regulatory activity and nuclear/cytoplasmic translocation of DAZAP1; DAZAP1 regulates endogenous splicing events involved in cell growth and its knockdown/overexpression causes cell proliferation defects. mRNA-seq, minigene splicing assay, tethering assay, MEK/Erk inhibitor treatment, phosphomutant analysis, siRNA knockdown, cell proliferation assay Nature communications High 24452013
2018 DAZAP1 binds cox6c mRNA in an intron-dependent manner (binding requires the last intron; no binding to intronless cox6c mRNA); DAZAP1 overexpression suppresses pre-mRNA splicing efficiency of cox6c and reduces mature COX6C protein; this regulates mitochondrial complex IV and cell growth. RNA immunoprecipitation, intronless vs. genomic expression vectors, overexpression and knockdown assays, Western blot Gene Medium 29505834
2020 DAZAP1 binds the 3'UTR of SLC7A11 mRNA and positively regulates its stability, thereby inhibiting ferroptosis; DAZAP1 knockdown reduces SLC7A11 mRNA stability and sensitizes HCC cells to sorafenib-induced ferroptosis. RNA immunoprecipitation, siRNA knockdown, mRNA stability assay, ferroptosis assay Experimental cell research Medium 33358859
2020 DAZAP1 silencing in ESCC cells causes exon skipping of TSC2 exon 26, producing a short TSC2 isoform that cannot be phosphorylated at Ser981 by AKT; this results in continuous TSC2 activation, inhibition of mTOR via RHEB, and sustained autophagy; starvation-induced miR-10b suppresses DAZAP1 to trigger this pathway. RNAi, RNAseq alternative splicing analysis, phosphorylation assay, mTOR/RHEB signaling assay, miRNA functional assay Theranostics Medium 32308763
2022 DAZAP1 regulates alternative splicing of KITLG mRNA (shown by RIP-seq and RIP-qPCR); DAZAP1-mediated KITLG splicing increases ERK phosphorylation and promotes myeloma cell proliferation. RIP-seq, RIP-qPCR, siRNA knockdown, lentiviral overexpression, ERK phosphorylation assay, xenograft tumor model Aging Medium 36242590
2023 DAZAP1 interacts with PXR (pregnane X receptor) as a paraspeckle component; this interaction is dissociated by the PXR ligand rifampicin; DAZAP1 (together with NEAT1_2 lncRNA) negatively regulates PXR-mediated CYP3A4 transcriptional induction by trapping PXR in paraspeckles in the absence of ligand. Co-immunoprecipitation in PXR-overexpressing HepG2 cells, siRNA knockdown, luciferase reporter assay for PXR response elements Drug metabolism and disposition Medium 37349114
2024 DAZAP1 undergoes liquid-liquid phase separation (LLPS) to accumulate in the nucleus where it enhances COX16 expression via regulation of pre-mRNA alternative splicing, thereby promoting mitochondrial respiration and OSCC invasion/metastasis. RNA sequencing, DAZAP1 knockdown/overexpression, LLPS assay, mouse OSCC model, EMT marker analysis Cancer research Medium 39120588
2025 p52-ZER6 promotes DAZAP1 transcription; DAZAP1 then binds the 3'-UTR of SLC7A11 mRNA to enhance its stability, increasing SLC7A11 expression and cellular glutathione levels, thereby reducing lipid peroxide accumulation and conferring ferroptosis resistance in colorectal cancer. Transcriptional reporter assay, RNA immunoprecipitation, mRNA stability assay, glutathione and lipid peroxide measurement Acta pharmaceutica Sinica. B Medium 40486833
2025 DAZAP1 binds USP34 mRNA and stabilizes it, leading to increased USP34 protein, which deubiquitinates and stabilizes PIN1, activating the MAPK signaling pathway in gastric cancer; DAZAP1 mRNA is itself protected from YTHDF2-mediated degradation by ALKBH5-catalyzed m6A demethylation. RNA immunoprecipitation, Western blot, ubiquitination assay, siRNA/overexpression, m6A/ALKBH5/YTHDF2 knockdown experiments Cell biology and toxicology Medium 41331184
2025 DAZAP1 regulates splicing and expression of ULK1 via nonsense-mediated mRNA decay control; DAZAP1-dependent ULK1 upregulation promotes mitophagy and OXPHOS to sustain gastric cancer stem cell metabolic demands. RNA immunoprecipitation, PCR, Seahorse metabolic assay, transmission electron microscopy, immunofluorescence, sphere formation assay, rescue overexpression JCI insight Medium 40401521
2025 DAZAP1 physically binds NOTCH1 and JAG1 mRNAs (shown by RNA immunoprecipitation and sequencing) to stabilize them, activating NOTCH/JAG1 signaling and promoting EMT, migration, and invasion in gastric cancer. RNA immunoprecipitation and sequencing (RIP-seq), mRNA stability assay, overexpression and knockdown, migration/invasion assays International journal of oncology Low 41789621

Source papers

Stage 0 corpus · 30 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA. Experimental cell research 81 33358859
2008 Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. Molecular and cellular biology 71 18391021
2014 The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration. Nature communications 51 24452013
2005 Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. Leukemia 47 15744350
2008 DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. RNA (New York, N.Y.) 42 18669443
2011 DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation. RNA (New York, N.Y.) 41 21576381
2006 A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein. RNA (New York, N.Y.) 40 16772659
2020 Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinoma. Theranostics 33 32308763
2007 Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia. Leukemia 30 17898785
2011 Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. PloS one 28 21858080
2001 Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. BMC genomics 27 11604102
2006 Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. The Biochemical journal 26 16848763
2024 DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma. Cancer research 24 39120588
2009 DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. Biochemical and biophysical research communications 20 19285026
2013 DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts. Nucleic acids research 19 23965306
2018 Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation. Gene 13 29505834
2004 Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Archives of histology and cytology 13 15700540
2023 MiR-320a upregulation improves IL-1β-induced osteoarthritis via targeting the DAZAP1 and MAPK pathways. Journal of orthopaedic surgery and research 10 37507717
2013 Differential translation of Dazap1 transcripts during spermatogenesis. PloS one 10 23658607
2005 Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. Fertility and sterility 10 16209998
2022 DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway. Aging 9 36242590
2022 DAZAP1 overexpression promotes growth of HCC cell lines: a primary study using CEUS. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 8 35091997
2025 p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization. Acta pharmaceutica Sinica. B 7 40486833
2023 NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction. Drug metabolism and disposition: the biological fate of chemicals 5 37349114
2025 DAZAP1 maintains gastric cancer stemness by inducing mitophagy. JCI insight 4 40401521
2012 Transcription-dependent nuclear localization of DAZAP1 requires an N-terminal signal. Biochemical and biophysical research communications 3 23111326
2026 RNA‑binding protein DAZAP1 promotes gastric cancer metastasis by enhancing NOTCH1 and JAG1 mRNA stability. International journal of oncology 1 41789621
2025 RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis. European journal of medical research 1 39754243
2025 An integrated analysis of second- and third-generation transcriptome sequencing technologies reveals the DAZAP1 function in pig testis. Animal reproduction 1 40584277
2025 DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer. Cell biology and toxicology 1 41331184

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