Affinage

DAPK2

Death-associated protein kinase 2 · UniProt Q9UIK4

Length
370 aa
Mass
42.9 kDa
Annotated
2026-06-09
36 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAPK2 is a Ca²⁺/calmodulin-regulated serine/threonine kinase that functions as a central pro-autophagic and pro-apoptotic effector across granulocyte differentiation, metabolic stress responses, and vascular and tumor biology (PMID:21497605, PMID:29717115, PMID:26038578). The kinase forms autoinhibited dimers through apposed catalytic domains, a conformation that precludes substrate binding (PMID:21497605) and is stabilized by 14-3-3 binding via phospho-Thr369, which protects the inhibitory autophosphorylation site Ser318 and blocks Ca²⁺/CaM access (PMID:34413451); activation is achieved through Ca²⁺/CaM or through AMPK-mediated phosphorylation at Ser289, which mimics CaM binding and relieves autoinhibition (PMID:29717115, PMID:31116076). Once active, DAPK2 suppresses mTORC1 by directly binding raptor and phosphorylating it at Ser721 (PMID:25361081) and promotes autophagy initiation by phosphorylating Beclin-1 to displace Bcl-XL (PMID:29717115), by phosphorylating SQSTM1/p62 to drive selective clearance of protein aggregates (PMID:27653365), and by supporting autophagic flux in adipocytes in a kinase-dependent manner (PMID:26038578). DAPK2 kinase activity also maintains mitochondrial integrity and oxidative phosphorylation (PMID:25741596) and drives MLC phosphorylation required for granulocyte motility (PMID:24163421). In the vasculature, DAPK2 phosphorylates PKM2 at Thr45 to drive its nuclear translocation and STAT1-dependent induction of adhesion molecules, promoting endothelial inflammation and atherogenesis (PMID:41614276). Its expression is transcriptionally activated by PU.1, C/EBPα, E2F1/KLF6 (via Sp1), and TAp73 and repressed by PML-RARα and KLF2 (PMID:24038216, PMID:18521079, PMID:28978663, PMID:41614276), while m6A modification deposited by METTL3 and read by YTHDF2 destabilizes its mRNA (PMID:34298122).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2008 Medium

    Established how DAPK2 transcription is wired to apoptotic transcription factors, defining DAPK2 as an obligate downstream effector of E2F1/KLF6-induced cell death.

    Evidence Promoter reporter assays, ChIP, Sp1-deficient cells, and siRNA knockdown with cell-death readout

    PMID:18521079

    Open questions at the time
    • Did not address kinase-substrate events downstream of induced DAPK2
    • Sp1-dependence rather than direct E2F1 binding leaves mechanism of promoter selection partial
  2. 2009 Medium

    Showed that restoring DAPK2 catalytic activity is sufficient to drive apoptosis in tumors that silence it by promoter methylation, validating DAPK2 as a tumor suppressor effector.

    Evidence Promoter methylation analysis and constitutively active CaM-deletion DAPK2 fusion in CD30-positive lymphoma cells

    PMID:19609235

    Open questions at the time
    • Pro-apoptotic substrates not identified
    • Constitutively active mutant bypasses physiological activation
  3. 2011 High

    Resolved the structural basis of DAPK2 autoinhibition, showing catalytic-domain dimerization occludes substrate binding.

    Evidence X-ray crystallography and SAXS of recombinant murine DAPK2 ± nucleotide

    PMID:21497605

    Open questions at the time
    • Did not capture activated/substrate-bound state
    • Did not address regulators that shift the dimer equilibrium in cells
  4. 2013 Medium

    Placed DAPK2 within myeloid differentiation by identifying its activating (PU.1, C/EBPα) and repressing (PML-RARα) transcriptional inputs and demonstrating functional rescue of neutrophil differentiation.

    Evidence ChIP for transcription-factor binding plus rescue in PU.1-knockdown APL cells

    PMID:24038216

    Open questions at the time
    • Did not define DAPK2 catalytic targets in differentiation
  5. 2013 Medium

    Demonstrated a cytoskeletal/motility function by linking DAPK activity to MLC phosphorylation and granulocyte chemotaxis in vitro and in vivo.

    Evidence Pharmacological DAPK inhibition, chemotaxis and F-actin/MLC assays, and a mouse peritonitis model

    PMID:24163421

    Open questions at the time
    • DAPK inhibitor is not DAPK2-selective
    • Direct MLC phosphorylation by DAPK2 not isolated from DAPK1
  6. 2014 High

    Identified the first direct DAPK2 phosphorylation substrate in autophagy control, showing DAPK2 represses mTORC1 via raptor Ser721.

    Evidence Reciprocal Co-IP, recombinant binding, in vitro kinase assay, and knockdown with mTORC1 activity readout

    PMID:25361081

    Open questions at the time
    • In vivo relevance of raptor Ser721 not established
    • Single lab
  7. 2014 Medium

    Revealed that loss of DAPK2 derepresses NF-κB to upregulate TRAIL death receptors, sensitizing resistant cancer cells to apoptosis independently of p53.

    Evidence siRNA knockdown, NF-κB reporter, surface DR4/DR5 flow cytometry, and TRAIL apoptosis assays in multiple lines

    PMID:25012503

    Open questions at the time
    • Mechanism connecting DAPK2 to NF-κB not molecularly defined
    • No kinase-substrate link shown
  8. 2015 Medium

    Showed DAPK2 kinase activity is required for autophagic flux in adipocytes and for maintaining mitochondrial integrity and oxidative phosphorylation.

    Evidence Gain/loss-of-function with kinase-dead controls; LC3-II flux, Seahorse, membrane potential and superoxide assays

    PMID:25741596 PMID:26038578

    Open questions at the time
    • Mitochondrial substrates of DAPK2 not identified
    • Whether mitochondrial defects are autophagy-dependent unresolved
  9. 2016 Medium

    Linked DAPK2 to selective autophagy by showing it phosphorylates SQSTM1/p62 to clear protein aggregates and protect against hepatotoxicity.

    Evidence AAV knockdown and ectopic expression with phospho-SQSTM1 immunoblot and a murine hepatocarcinogenesis model

    PMID:27653365

    Open questions at the time
    • Direct in vitro kinase assay on p62 not shown
    • Phosphosite not mapped
  10. 2017 Medium

    Established a p73-DAPK2 axis with feedback, where TAp73 activates and ΔNp73 represses DAPK2, and DAPK2 binds ATG5 and stabilizes p73.

    Evidence Promoter reporter, TP73/DAPK2 knockdown, DAPK2-ATG5 Co-IP, and apoptosis/autophagy assays in APL cells

    PMID:28978663

    Open questions at the time
    • DAPK2-ATG5 interaction not shown to be catalytic
    • Feedback stoichiometry undefined
  11. 2018 High

    Defined the activating upstream kinase by showing AMPK phosphorylates DAPK2 at Ser289 to mimic CaM binding and relieve autoinhibition, driving Beclin-1 phosphorylation and autophagy.

    Evidence In vitro kinase assays, phosphosite mapping, Co-IP, and autophagy flux assays

    PMID:29717115 PMID:31116076

    Open questions at the time
    • Quantitative contribution of Ser289 versus Ca²⁺/CaM in cells unresolved
  12. 2021 High

    Provided the structural mechanism of negative regulation, showing 14-3-3 binding at pThr369 locks DAPK2 in an inactive dimer and shields Ser318.

    Evidence Crystal structure of the human DAPK2:14-3-3 complex with ITC, SAXS, and mutagenesis

    PMID:34413451

    Open questions at the time
    • Kinase that generates pThr369 not identified
    • Cellular conditions that release 14-3-3 not defined
  13. 2021 Medium

    Identified an epitranscriptomic silencing route, with smoking-induced METTL3/YTHDF2 m6A decay of DAPK2 mRNA derepressing NF-κB to promote lung cancer progression.

    Evidence MeRIP, METTL3/YTHDF2 knockdown, mRNA stability assays, and in vitro/in vivo NSCLC assays

    PMID:34298122

    Open questions at the time
    • Direct m6A sites on DAPK2 not pinpointed mechanistically
  14. 2026 High

    Established DAPK2 as a pro-inflammatory vascular kinase by mapping its direct PKM2 Thr45 phosphorylation driving nuclear PKM2-STAT1 adhesion-molecule induction and atherogenesis in vivo.

    Evidence Mass spec phosphosite mapping, PLA, EC-specific Dapk2 knockout in Apoe-/- mice, and Pkm2T45A/T45E knock-in mice

    PMID:41614276

    Open questions at the time
    • How disturbed flow activates DAPK2 catalytically not fully resolved
  15. 2025 Medium

    Connected DAPK2 dysfunction to mitochondrial cristae remodeling via Mic60 lactylation, promoting anoikis resistance and metastasis in TKI-resistant lung cancer.

    Evidence Mass spectrometry, IP, anoikis-resistant models, and tail-vein metastasis assays

    PMID:40812308

    Open questions at the time
    • Whether DAPK2 directly controls Mic60 lactylation is not established
    • Kinase activity dependence unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of the kinase generating the 14-3-3-binding pThr369 and the in vivo physiological hierarchy among DAPK2's many substrates (raptor, Beclin-1, p62, PKM2) remain unresolved.
  • No upstream Thr369 kinase identified
  • No unified accounting of which substrate dominates in a given tissue context

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0016740 transferase activity 3 GO:0098772 molecular function regulator activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005739 mitochondrion 2 GO:0005829 cytosol 2
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-9612973 Autophagy 4 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 2
Partners
14-3-3AMPKATG5BECN1MTORPKM2RPTORULK1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 Crystal and solution structures of murine DAPK2 revealed that DAPK2 forms dimers through apposed catalytic domains in an autoinhibited conformation that precludes protein substrate binding; the 'basic loop' fingerprint of the DAPK family plays a central role in kinase domain dimerization, and two distinct active-site conformations are observed upon nucleotide binding. X-ray crystallography and solution scattering (SAXS) of recombinant murine DAPK2 with and without nucleotide ligands Journal of molecular biology High 21497605
2014 DAPK2 directly interacts with and phosphorylates components of mTORC1; co-immunoprecipitation showed DAPK2 associates with mTOR, raptor, and ULK1, recombinant protein-binding assay confirmed direct DAPK2–raptor interaction, and in vitro kinase assay showed DAPK2 phosphorylates raptor at Ser721. DAPK2 knockdown increased mTORC1 kinase activity and reduced autophagy induced by amino acid deprivation or elevated intracellular Ca²⁺. Co-immunoprecipitation, recombinant protein-binding assay, in vitro kinase assay, siRNA knockdown with mTORC1 substrate phosphorylation readout Cell death and differentiation High 25361081
2018 AMPK phosphorylates DAPK2 at a site between the catalytic and calmodulin-binding domains (Ser289), activating DAPK2 by functionally mimicking calmodulin binding and mitigating inhibitory autophosphorylation. Activated DAPK2 in turn phosphorylates Beclin-1, causing dissociation of its inhibitor Bcl-XL and promoting autophagy; DAPK2 depletion reduced autophagy in response to AMPK activation. In vitro kinase assays, phosphosite mapping, co-immunoprecipitation, siRNA knockdown, autophagy flux assays Nature communications High 29717115
2021 14-3-3 proteins bind DAPK2 via a canonical mode III motif created by phosphorylation of Thr369 at the DAPK2 C-terminus. X-ray crystallographic analysis of the full-length human DAPK2:14-3-3 complex showed that 14-3-3 binding stabilizes DAPK2 dimers, protects the inhibitory autophosphorylation site Ser318 from dephosphorylation, and prevents Ca²⁺/CaM binding, thereby inactivating DAPK2. The interaction is further enhanced by the diterpene glycoside Fusicoccin A. X-ray crystallography, biophysical binding assays (ITC, SAXS), phosphosite mapping, mutagenesis Communications biology High 34413451
2019 Ser289 phosphorylation enhances DAPK2 catalytic activity (analogous to its effect on DAPK1); AMPK-mediated Ser289 phosphorylation of DAPK2 was compared to RSK-mediated phosphorylation of DAPK1 in the same cells, and the signaling pathways leading to Ser289 phosphorylation are mutually exclusive between DAPK1 and DAPK2. In-cell kinase activity assays, phospho-specific immunoblotting, pathway inhibitor treatments Cell cycle Medium 31116076
2009 DAPK2 promoter hypermethylation silences DAPK2 expression in Hodgkin lymphoma cell lines; a constitutively active calmodulin-deletion mutant of DAPK2 fused to CD30 ligand (immunokinase DAPK2'-CD30L) selectively induced apoptosis and inhibited proliferation in CD30-positive/DAPK2-negative tumor cells, demonstrating that restoration of DAPK2 catalytic activity is sufficient for pro-apoptotic function. Promoter methylation analysis, recombinant fusion protein construction, cell viability and apoptosis assays in tumor cell lines Journal of immunotherapy Medium 19609235
2013 DAPK2 positively regulates motility of human neutrophils and eosinophils in response to intermediary chemoattractants; pharmacological inhibition of DAPK activity abolished granulocyte migration associated with reduced MLC phosphorylation and loss of cell polarization with radial F-actin, and reduced neutrophil recruitment to the peritoneum in a mouse peritonitis model. Pharmacological DAPK inhibition, ex vivo chemotaxis assays, F-actin/MLC phosphorylation analysis, in vivo peritonitis model Journal of leukocyte biology Medium 24163421
2013 DAPK2 expression is transcriptionally activated by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation; PML-RARα binds the DAPK2 promoter and represses its transcription in APL. Restoration of DAPK2 expression in PU.1-knockdown APL cells partially rescued neutrophil differentiation, establishing DAPK2 as a relevant PU.1 downstream effector. ChIP (PML-RARA and PU.1 binding at DAPK2 promoter), ectopic expression, PU.1 knockdown, differentiation assays Journal of leukocyte biology Medium 24038216
2008 E2F1 and KLF6 transcriptionally activate the DAPK2 promoter via a GC-rich region upstream of exon 1 in an Sp1-dependent manner (no canonical E2F binding sites); ChIP confirmed Sp1 recruitment (and lesser E2F1/KLF6 recruitment) to the DAPK2 promoter. DAPK2 induction mediates the pro-apoptotic effects of both E2F1 and KLF6, as DAPK2 knockdown significantly reduced cell death upon activation of either transcription factor. Promoter reporter assays, chromatin immunoprecipitation (ChIP), Sp1-deficient insect cells, mithramycin A treatment, siRNA knockdown, cell death assays Oncogene Medium 18521079
2014 Genetic ablation of DAPK2 by RNAi causes NF-κB phosphorylation and transcriptional activation, leading to upregulation of DR4 and DR5 (TRAIL receptors) on the cell surface and sensitizing resistant cancer cells to TRAIL-induced apoptosis in a p53-independent manner. siRNA knockdown, NF-κB reporter assay, cell surface flow cytometry for DR4/DR5, TRAIL apoptosis assays in multiple cancer cell lines Cell death and differentiation Medium 25012503
2015 Adenoviral DAPK2 overexpression in 3T3-L1 adipocytes increased autophagic clearance in nutrient-rich conditions in a kinase activity-dependent manner; conversely, siRNA-mediated DAPK2 inhibition in human preadipocytes decreased LC3-II accumulation rates measured with lysosome inhibitors, demonstrating DAPK2 kinase activity is required for autophagic flux in adipocytes. Adenoviral overexpression (kinase-active and kinase-dead), siRNA knockdown, LC3-II accumulation assay with lysosome inhibitors in 3T3-L1 and human preadipocytes Diabetes Medium 26038578
2016 DAPK2 transcriptional activation by thyroid hormone (TH) enhances phosphorylation of SQSTM1/p62, promoting selective autophagic clearance of protein aggregates; ectopic DAPK2 expression attenuated DEN-induced hepatotoxicity and DNA damage via enhanced autophagy, while DAPK2 knockdown had the opposite effect. Adeno-associated virus knockdown, ectopic DAPK2 expression, phospho-SQSTM1 immunoblot, autophagy flux assays, murine hepatocarcinogenesis model Autophagy Medium 27653365
2017 TAp73 isoform binds to and activates the DAPK2 promoter, whereas ΔNp73 inhibits DAPK2 transcription; DAPK2 is an important downstream effector of p73 in ATO-induced apoptosis. Conversely, the p73-DAPK2 pathway is essential for ATRA-induced autophagy mediated by a direct interaction between DAPK2 and ATG5. DAPK2 also binds and stabilizes p73 protein, forming a positive feedback loop. Promoter reporter assay (TAp73/ΔNp73), siRNA knockdown of TP73 and DAPK2, co-immunoprecipitation of DAPK2-ATG5, apoptosis and autophagy assays in APL cells Journal of leukocyte biology Medium 28978663
2015 RNA interference-mediated depletion of endogenous DAPK2 in cancer cells causes decreased oxidative phosphorylation, destabilized mitochondrial membrane potential, increased mitochondrial superoxide anion production, and activation of ERK, JNK, and p38 stress kinases; overexpression of a kinase-dead DAPK2 mutant further enhanced oxidative stress, indicating that DAPK2 kinase activity is required to maintain mitochondrial integrity. siRNA knockdown, kinase-dead mutant overexpression, Seahorse metabolic flux analysis, mitochondrial membrane potential assay, superoxide detection, stress kinase immunoblotting Cell death & disease Medium 25741596
2021 Cigarette smoking-induced METTL3-mediated m6A modification of DAPK2 mRNA is read by YTHDF2, resulting in decreased DAPK2 mRNA stability and reduced DAPK2 expression; downregulation of DAPK2 activates NF-κB signaling to promote NSCLC proliferation and migration. m6A sequencing/MeRIP, METTL3/YTHDF2 knockdown, mRNA stability assay, NF-κB pathway inhibitor (BAY 11-7085), in vitro and in vivo functional assays Cancer letters Medium 34298122
2025 DAPK2 dysfunction alters Mic60 (mitofilin) protein in mitochondrial cristae by promoting its lactylation, increasing cristae abundance and compactness and activating mitochondrial metabolism, leading to anoikis resistance and enhanced metastasis in EGFR-TKI-resistant lung cancer cells. Mass spectrometry, immunoprecipitation, anoikis-resistant cell model, mouse tail vein metastasis model, Mic60 lactylation analysis, mitochondrial metabolic assays Developmental cell Medium 40812308
2026 DAPK2 directly phosphorylates PKM2 at threonine 45, causing PKM2 dimerization and nuclear translocation; nuclear PKM2 activates VCAM-1 and ICAM-1 expression by interacting with STAT1, promoting endothelial inflammation in response to oscillatory shear stress. KLF2 suppresses DAPK2 transcription, and OSS-induced KLF2 downregulation leads to DAPK2 upregulation. EC-specific Dapk2 deficiency reduced atherogenesis in Apoe-/- mice, and Pkm2T45A overexpression mitigated disturbed flow-induced atherogenesis. Mass spectrometry phosphosite identification, immunoprecipitation, proximity ligation assay, dominant-negative DAPK2 mutant, EC-specific Dapk2 knockout in Apoe-/- mice (carotid ligation and Western diet models), Pkm2T45A and Pkm2T45E knock-in overexpression mice Circulation High 41614276
2019 PCB118 enhances binding between Tubb3 (tubulin beta 3) and DAPK2 in thyroid cells; siRNA knockdown of Tubb3 suppressed DAPK2 protein expression and PKD phosphorylation, while DAPK2 (downstream of Tubb3) activated PKD which in turn phosphorylated VPS34, mediating autophagy. DAPK2 overexpression following PCB118 exposure upregulated PKD and VPS34 in the DAPK2/PKD/VPS34 pathway. Co-immunoprecipitation (Tubb3-DAPK2 interaction), siRNA knockdown, overexpression, immunofluorescence, rat in vivo model Archives of toxicology Low 31020377
2026 In osteoblasts, VGLL3 regulates DAPK2 expression (identified by RNA-seq of Vgll3-KD cells); DAPK2 knockdown phenocopied Vgll3 loss, reducing autophagic flux and impairing osteoblast differentiation. DAPK2 overexpression partially rescued autophagy and osteogenic differentiation in Vgll3-deficient cells, and FOXM1 was implicated as a potential transcriptional regulator of DAPK2 in this context. RNA-seq, shRNA knockdown (Vgll3 and Dapk2), DAPK2 overexpression rescue, LC3-II/p62 immunoblot, transmission electron microscopy, alkaline phosphatase/Alizarin Red staining BioFactors Low 42052791
2026 YTHDF3 directly recognizes m6A-modified Dapk2 transcripts and promotes their decay, thereby suppressing DAPK2 protein levels; melatonin rescues YTHDF3 expression under mechanical unloading, leading to DAPK2 mRNA degradation that supports osteoblast differentiation and survival. DAPK2 was characterized as a negative regulator of osteoblast differentiation and survival. m6A-seq/MeRIP, YTHDF3 KD/OE, Dapk2 KD, hindlimb unloading mouse model, western blot, qPCR, mineralization assays Journal of pineal research Low 42149012

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy. Cell death & disease 176 28703801
2015 DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity. Diabetes 72 26038578
2014 DAPK2 is a novel regulator of mTORC1 activity and autophagy. Cell death and differentiation 59 25361081
2016 Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy 56 27653365
2015 miR-520h is crucial for DAPK2 regulation and breast cancer progression. Oncogene 46 25982274
2015 Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2. Journal of human genetics 46 26334104
2018 Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nature communications 36 29717115
2009 Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells. Journal of immunotherapy (Hagerstown, Md. : 1997) 36 19609235
2008 DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function. Oncogene 36 18521079
2014 DAPK2 is a novel modulator of TRAIL-induced apoptosis. Cell death and differentiation 35 25012503
2021 Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway. Cancer letters 32 34298122
2011 Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase. Journal of molecular biology 29 21497605
2016 MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. Oncotarget 28 27049921
2021 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Communications biology 27 34413451
2013 DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. Journal of leukocyte biology 25 24163421
2023 Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2. International journal of nanomedicine 24 36636640
2025 Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis. Developmental cell 19 40812308
2013 The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL. Journal of leukocyte biology 19 24038216
2015 DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function. Cell death & disease 18 25741596
2023 Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade. Marine drugs 17 36827114
2020 miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2. International journal of molecular sciences 16 32244500
2017 Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. Journal of leukocyte biology 16 28978663
2023 CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis. Journal of diabetes 15 37735821
2016 E2F-1 promotes DAPK2-induced anti-tumor immunity of gastric cancer cells by targeting miR-34a. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 15 27704360
2018 Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway. International journal of biological macromolecules 13 30243997
2019 2,3',4,4',5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2/PKD/VPS34 pathway. Archives of toxicology 10 31020377
2024 The role of DAPK2 as a key regulatory element in various human cancers: a systematic review. Molecular biology reports 8 39105958
2021 DAPK2 activates NF-κB through autophagy-dependent degradation of I-κBα during thyroid cancer development and progression. Annals of translational medicine 8 34422995
2025 LncRNA432-miR-21-y-DAPK2 ceRNA crosstalk regulates antibacterial response in hypoxia stress through mediating mitochondrial apoptosis in teleost fish. International journal of biological macromolecules 6 39798738
2019 Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways. Cell cycle (Georgetown, Tex.) 6 31116076
2025 PIWI-interacting RNA MIABEPIR regulates cerebral endothelial cell function via DAPK2 pathway in offspring following maternal immune activation. Clinical and translational medicine 2 40000424
2025 Investigate of LOC101928988 Regulatory Effect on the DAPK2 Transcription in Breast Tumors. Cancer reports (Hoboken, N.J.) 1 39971705
2025 A potential mechanism of triclosan-induced neurotoxicity in zebrafish at environmental Concentrations: Splicing disruption of tecra mediates the circRNA266/miR-214/dapk2-gad2 axis. Environmental research 1 40701386
2026 DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis. Circulation 0 41614276
2026 VGLL3 Regulates DAPK2-Mediated Autophagy During Osteoblast Differentiation. BioFactors (Oxford, England) 0 42052791
2026 Melatonin Counteracts Mechanical Unloading-Induced Bone Loss Through YTHDF3-Mediated m6A Modification of Dapk2 mRNA. Journal of pineal research 0 42149012

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