Affinage

DAB2

Disabled homolog 2 · UniProt P98082

Length
770 aa
Mass
82.4 kDa
Annotated
2026-06-09
100 papers in source corpus 42 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 10/10 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DAB2 is a cargo-selective clathrin adaptor that couples NPXY/FxNPXY-motif receptors of the LDL-receptor family to the endocytic machinery while also acting as a signaling scaffold that restrains growth-factor and Wnt pathways (PMID:16984970, PMID:12805222). Its phosphotyrosine-binding (PTB/PID) domain recognizes NPXY motifs in megalin/gp600, LDLR, apoER2 and the cubam component amnionless, clustering these receptors into clathrin-coated pits independently of AP-2 and, for some cargo, ARH (PMID:10769163, PMID:16984970, PMID:16101684, PMID:20088845). DAB2 functions through defined cargo selectivity: it routes LDLR and beta1-class inactive integrins but not NPC1L1 or alpha5/alphav integrins, and its EH-domain-binding sites recruit Eps15 and intersectin specifically to drive integrin internalization without affecting transferrin uptake (PMID:19581412, PMID:22648170, PMID:25331956). In renal proximal tubule its localization is mutually dependent with megalin, and the endocytosis-competent p96 isoform is required for megalin trafficking and embryonic viability (PMID:16263760, PMID:15870384). A C-terminal myosin-VI-interacting region links endocytic vesicles to the actin cytoskeleton through dynamic, high-turnover multimerization that supports cargo processivity (PMID:11967127, PMID:33372034). DAB2 governs receptor fate beyond internalization, controlling TGFbeta receptor recycling from early endosomes and post-endocytic sorting and stability of CFTR (PMID:20881059, PMID:21995445). As a signaling scaffold, its proline-rich domain binds the Grb2 SH3 domains to displace SOS and suppress ERK/MAPK, engages c-Src to hold it inactive, and associates with TAK1 to drive JNK activation, fibronectin induction and EMT (PMID:9569023, PMID:11371563, PMID:15894542, PMID:12473651). DAB2 inhibits canonical Wnt/beta-catenin signaling by stabilizing the destruction complex: it binds Dishevelled-3 and Axin, blocks PP1-mediated Axin dephosphorylation, prevents LRP5/6-mediated Axin degradation, and diverts CK2-phosphorylated LRP6 into clathrin rather than caveolar endocytosis (PMID:12805222, PMID:19581931, PMID:17922036, PMID:22491013). DAB2 activity is set by phosphorylation — PKC at Ser24 (required for AP-1 inhibition), Akt at Ser448/449 (required for albumin endocytosis), and mitotic phosphorylation that displaces it from the membrane to suppress endocytosis during division — and its protein level is controlled translationally through TGFbeta/Akt2-driven hnRNP E1 release from its 3'UTR (PMID:10542228, PMID:20154680, PMID:21097498, PMID:22218591, PMID:25253241). In immune cells DAB2 is a FOXP3 target required for Treg suppressive function and a negative regulator of TLR-induced dendritic cell and macrophage activation, with promoter activity governed by GATA-6 and HDAC5-mediated H3K9 deacetylation (PMID:19767570, PMID:30873168, PMID:38776988, PMID:10779506).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2000 High

    Established the molecular basis of DAB2 cargo recognition by showing its PTB/PID domain reads a specific NPXY motif in an LDL-receptor-family tail, defining DAB2 as a receptor-tail adaptor.

    Evidence Yeast two-hybrid, in vitro binding and Co-IP mapping DAB2-PID to the third PsiXNPXY motif of megalin; GATA-6 reporter and KO defining promoter control

    PMID:10769163 PMID:10779506

    Open questions at the time
    • Did not establish whether DAB2 recruits megalin into coated pits or merely binds the tail
    • Mechanism of GATA-6 transactivation without its DNA-binding domain unresolved
  2. 2001 High

    Connected DAB2 to growth-factor signaling and tumor suppression by showing it competes with SOS for Grb2 and suppresses ERK, and that PKC phosphorylation at Ser24 is required for AP-1 inhibition.

    Evidence Co-IP, peptide competition, transfection rescue, ERK/AP-1 reporters; in vitro kinase assay with isoform-specific PKC and S24A mutant

    PMID:10542228 PMID:11371563 PMID:11687976 PMID:9569023

    Open questions at the time
    • Did not resolve how endocytic and signaling functions are coordinated
    • ILK/anoikis link rests on single-lab evidence
  3. 2002 High

    Defined DAB2's in vivo physiology and its cytoskeletal coupling, showing it is needed for visceral-endoderm development and renal coated-pit/megalin trafficking and that it links vesicles to actin via myosin VI.

    Evidence Mouse KO and conditional deletion with urinalysis and EM; yeast two-hybrid, in vitro binding, Co-IP and co-localization for myosin VI; DIP1/2 GAP interaction by yeast two-hybrid

    PMID:11812785 PMID:11927540 PMID:11967127

    Open questions at the time
    • Did not separate endocytic from developmental-signaling contributions to the embryonic phenotype
    • DIP1/2 interaction medium-confidence, single lab
  4. 2003 High

    Placed DAB2 as a negative regulator of canonical Wnt signaling and a coordinator of the clathrin coat, via Dishevelled-3 binding/Axin stabilization and CIN85 recruitment.

    Evidence cDNA screen, Co-IP, beta-catenin/TCF reporter, in vitro binding, Dab2-null MEFs; peptide-binding mapping of the PKPAPR-CIN85 interaction

    PMID:12805222 PMID:14596919

    Open questions at the time
    • Did not define the biochemical step at which Axin is stabilized
    • CIN85 interaction medium-confidence with limited mechanistic depth
  5. 2005 High

    Defined DAB2 as a TGFbeta effector for EMT and integrin biology, linking it to beta1 integrin, FAK, and TAK1-JNK-driven fibronectin induction, and resolved the isoform requirement for megalin endocytosis.

    Evidence siRNA knockdown with species-specific rescue, FAK and JNK assays, Dab2-TAK1 Co-IP, dominant-negative TAK1; isoform-specific p96/p67 knock-in mice; reciprocal megalin/Dab2 KO and RAP internalization

    PMID:15734730 PMID:15870384 PMID:15894542 PMID:16101684 PMID:16263760

    Open questions at the time
    • Did not define how DAB2 switches between integrin-adhesion and endocytosis roles
    • apoER2 study did not establish in vivo relevance of the clathrin route
  6. 2006 High

    Demonstrated DAB2 acts as the primary cargo-specific adaptor for LDLR clustering, AP-2-independent and parallel to ARH.

    Evidence siRNA knockdown, LDL uptake and fluorescence endocytosis assays, domain-function mutagenesis across multiple cell types

    PMID:16984970

    Open questions at the time
    • Did not resolve the in vivo division of labor between DAB2 and ARH
  7. 2009 High

    Extended DAB2's adaptor role to bulk inactive-integrin endocytosis controlling migration, refined its Wnt mechanism to PP1 competition on Axin, established a clathrin-assembly activity for the p82 isoform, and identified it as a FOXP3-dependent Treg gene.

    Evidence SILAC surface proteomics + siRNA + migration assays; Co-IP and in vitro PP1 competition with zebrafish epistasis; GFP-fusion FRAP/live imaging of p82 clathrin assemblies; Treg KO with in vitro/in vivo suppression assays

    PMID:19000037 PMID:19581412 PMID:19581931 PMID:19767570

    Open questions at the time
    • Did not identify the DAB2 target genes mediating Treg suppression
    • Did not connect integrin endocytosis quantitatively to in vivo migration
  8. 2010 High

    Established post-endocytic and translational control axes: DAB2 directs TGFbeta receptor recycling, its expression is induced via TGFbeta/Akt2-driven hnRNP E1 release from its 3'UTR, and amnionless FXNPXF motifs bind DAB2 redundantly with ARH.

    Evidence siRNA recycling/endosome morphology and Smad2 assays; RNA-protein binding, Akt2 kinase and translation reporter; yeast two-hybrid and endocytosis assays for amnionless

    PMID:20088845 PMID:20154680 PMID:20881059

    Open questions at the time
    • Did not define how DAB2 selects receptors for recycling versus degradation
    • Amnionless interaction medium-confidence, single lab
  9. 2010 High

    Revealed cell-cycle regulation of DAB2 endocytosis through mitotic phosphorylation that displaces DAB2 from the membrane and suppresses NPXY-cargo uptake.

    Evidence Live imaging, FRAP, Co-IP, NPXY-cargo internalization, Ser/Thr-to-Ala mutagenesis with functional rescue, pharmacological mitotic arrest

    PMID:21097498

    Open questions at the time
    • Did not identify the mitotic kinase responsible
  10. 2012 High

    Mechanistically dissected DAB2 cargo selectivity and trafficking: EH-domain recruitment of Eps15/intersectin drives integrin (not transferrin) internalization, CK2-phosphorylated LRP6 is routed to clathrin to block Wnt, and DAB2 controls CFTR post-endocytic sorting and stability.

    Evidence EH-binding-site mutagenesis with cargo-specific assays; LRP6-S1579A mutagenesis, clathrin/caveolin assays, zebrafish and tumor models; parallel DAB2 vs AP-2 depletion with CFTR biotinylation and half-life

    PMID:21995445 PMID:22491013 PMID:22648170

    Open questions at the time
    • Did not define how EH-protein recruitment is restricted to specific cargo
    • Did not establish how DAB2 distinguishes recycling from degradative routing of CFTR
  11. 2012 High

    Identified Akt as a direct DAB2 kinase, phosphorylating Ser448/449 to enable albumin endocytosis and to control DAB2 subcellular distribution.

    Evidence Co-IP, GST pull-down domain mapping, yeast two-hybrid, Akt-isoform siRNA, S448/449A mutagenesis, albumin endocytosis and localization imaging

    PMID:22218591 PMID:25253241

    Open questions at the time
    • Did not place Akt-DAB2 phosphorylation within a physiological signaling input in vivo
  12. 2014 High

    Resolved DAB2 control of TGFbeta receptor membrane dynamics and pathway selectivity, restricting TbetaRI lateral diffusion and clathrin uptake to suppress JNK without affecting Smad.

    Evidence Single-particle tracking/FRAP, siRNA/overexpression, JNK and Smad assays, cholesterol depletion; NPC1L1 cargo-selectivity Co-IP/knockdown showing DAB2/ARH bind LDLR but not NPC1L1

    PMID:24648493 PMID:25331956

    Open questions at the time
    • Did not reconcile DAB2 promoting versus restraining TGFbeta JNK signaling across cell contexts
  13. 2016 High

    Confirmed DAB2's developmental and metabolic in vivo roles in Wnt-dependent cardiogenesis and, redundantly with ARH, in systemic cholesterol homeostasis.

    Evidence Zebrafish CRISPR KO with DKK1 rescue and cardiomyocyte counting; arh/dab2 double-KO mice with serum cholesterol and HMG-CoA reductase analysis

    PMID:26755607 PMID:27005486

    Open questions at the time
    • Did not define how endothelial DAB2 signals to hepatocyte cholesterol synthesis
  14. 2018 High

    Defined a DAB2 scaffold function in vascular pathology, recruiting apoER2 and PP2A assembly machinery to inactivate Akt/eNOS in antiphospholipid antibody-induced thrombosis.

    Evidence Co-IP, PP2A methylation and Akt/eNOS phosphorylation assays, endothelial-specific mouse thrombosis model

    PMID:29500169

    Open questions at the time
    • Did not establish whether this scaffold function requires DAB2 endocytic activity
  15. 2021 High

    Provided biophysical basis for DAB2-myosin VI cargo transport, showing dynamic multimerization promotes processivity while preserving cortical actin.

    Evidence Single-molecule kinetics, in vitro motility, DNA-origami cargo mimetics, reconstituted minimal actin cortex

    PMID:33372034

    Open questions at the time
    • Did not show the multimerization dynamics operate in cells
  16. 2024 Medium

    Extended DAB2's immunoregulatory role and epigenetic control, showing HDAC5-mediated H3K9 deacetylation represses DAB2 and that DAB2 blocks macrophage M1 polarization, paralleling its negative regulation of dendritic-cell TLR responses.

    Evidence ChIP for H3K9ac, HDAC5/DAB2 siRNA-overexpression, macrophage polarization, DSS colitis model; BMDC TLR stimulation with TRIF/MyD88 analysis and immune phenotyping

    PMID:30873168 PMID:38776988

    Open questions at the time
    • Did not define the DAB2 effector mechanism limiting inflammatory polarization
    • Both rest on single-lab evidence
  17. 2023 High

    Compared DAB2 against megalin and cubam in proximal-tubule albumin uptake, showing each drives endocytic flux distinctly without disrupting pathway integrity.

    Evidence Parallel CRISPR KO in a differentiated proximal-tubule line with quantitative cargo and fluid-phase assays plus megalin KO mice

    PMID:37126375

    Open questions at the time
    • Did not resolve the relative contribution of DAB2 to bulk versus receptor-mediated albumin uptake

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DAB2's distinct functions — cargo-selective endocytosis, receptor recycling, Wnt/MAPK scaffold signaling, and immune regulation — are integrated and toggled within a single cell by its phosphorylation, isoform, and expression controls remains unresolved.
  • No unified model linking phosphorylation states to functional switching
  • No structural model of DAB2 engaging multiple partner classes
  • In vivo significance of many signaling-scaffold roles untested by genetic perturbation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 4 GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 2 GO:0008289 lipid binding 2
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 3 GO:0005768 endosome 2
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-168256 Immune System 3 R-HSA-1430728 Metabolism 2
Partners
AXINDVL3EPS15GRB2ITGB1LRP6MYO6TAK1
Complex memberships
clathrin coatcubam (cubilin/amnionless) receptor complex

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 Dab2 binds myosin VI via a C-terminal region of Dab2, linking endocytic vesicles to the actin cytoskeleton; the interaction was confirmed by yeast two-hybrid, in vitro binding assays, co-immunoprecipitation, and co-localization in clathrin-coated pits/vesicles at the apical domain of polarized epithelial cells. Yeast two-hybrid, mammalian two-hybrid, in vitro binding assay, co-immunoprecipitation, confocal co-localization Traffic (Copenhagen, Denmark) High 11967127
2002 Dab2 is required in the visceral endoderm for embryo development prior to gastrulation (likely via TGFbeta/Nodal signaling), and is required in kidney proximal tubule cells for clathrin-coated pit formation and megalin/gp330-mediated lipoprotein receptor trafficking; conditional deletion from embryo proper yields viable mice with normal development but proteinuria. Targeted gene knockout in mouse, conditional deletion using Cre-lox, urinalysis, electron microscopy of clathrin-coated pits The EMBO journal High 11927540
2000 The phosphotyrosine interaction domain (PID/PTB) of Dab2 binds the third PsiXNPXY motif in the cytoplasmic tail of megalin (gp600), as shown by yeast two-hybrid screening, in vitro binding assay, and co-immunoprecipitation from renal cell lysates. Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation The Biochemical journal High 10769163
2006 Dab2 acts as a cargo-specific endocytic adaptor for LDL receptors (LDLR), mediating their clustering into coated pits independently of AP-2 and ARH; this activity requires Dab2 binding to clathrin, LDLR, and phospholipids. In HeLa cells and fibroblasts, Dab2 is the primary adaptor for LDLR internalization, whereas ARH can compensate but requires AP-2. siRNA knockdown, fluorescence endocytosis assays, LDL uptake assays, domain-function mutagenesis Journal of cell science High 16984970
2003 Dab2 N-terminal domain interacts with Dishevelled-3 (Dvl-3) and negatively regulates canonical Wnt/beta-catenin signaling; Dab2 overexpression maintains Dab2-Dvl-3 association, disrupts Dvl-3-axin interaction, stabilizes axin, and reduces nuclear beta-catenin and cyclin D1. Dab2-null MEFs exhibit constitutive Wnt signaling. Small-pool cDNA screen, co-immunoprecipitation, beta-catenin/TCF reporter assay, in vitro binding assay, Dab2 KO MEFs The EMBO journal High 12805222
1998 Dab2 binds the SH3 domains of Grb2 via its C-terminal proline-rich domain (residues 600-730, key site #661-669), competing with Sos for Grb2 binding; both SH3 domains of Grb2 are required cooperatively for binding to Dab2. Co-immunoprecipitation from macrophage lysates, transfection competition assay in 293 cells, peptide inhibition, domain-binding experiments Oncogene High 9569023
2001 DOC-2/DAB2 suppresses ERK phosphorylation by binding Grb2 via its second proline-rich domain in a growth-factor-stimulated manner, thereby interrupting the Grb2-SOS interaction and blocking downstream MAPK signaling; reduced ERK phosphorylation is rescued by increasing Grb2 expression or using a specific blocking peptide. Peptide competition, transfection rescue, co-immunoprecipitation, ERK phosphorylation assay, AP-1 reporter assay The Journal of biological chemistry High 11371563
1999 PKC (specifically PKCbetaII, PKCgamma, and PKCdelta) directly phosphorylates Dab2 at Ser24; mutation of Ser24 to Ala abolishes PKC-induced phosphorylation and abrogates TPA-induced AP-1 inhibition, indicating that Ser24 phosphorylation is required for Dab2's growth-inhibitory function. In vitro kinase assay with recombinant substrates and isoform-specific PKC, site-directed mutagenesis (S24A), AP-1 reporter assay The Journal of biological chemistry High 10542228
2005 TGFbeta induces Dab2 expression and increases its binding to beta1 integrin at the membrane; siRNA silencing of Dab2 inhibits integrin activation (reduced focal adhesion kinase phosphorylation), cell adherence, and TGFbeta-mediated EMT, while re-expression of human Dab2 rescues these effects. Dab2 ablation also blocks retinoic acid-induced visceral endoderm differentiation. siRNA knockdown, siRNA rescue (species-specific), FAK phosphorylation assay, cell adhesion assay, F9 differentiation model The Journal of biological chemistry High 15734730
2005 Dab2 directly stimulates JNK activity and is required for TGFbeta-mediated fibronectin induction and cell migration; TGFbeta stimulates association of Dab2 with the MAP3K TAK1, and attenuation of TAK1 abolishes TGFbeta-induced fibronectin induction. siRNA stable knockdown, JNK kinase assay, co-immunoprecipitation (Dab2-TAK1), dominant-negative TAK1, fibronectin induction assay, cell migration assay The Journal of biological chemistry High 15894542
2005 Dab2 p96 isoform, which retains endocytic protein-binding sites absent from p67, is required for efficient megalin endocytosis in visceral endoderm; knock-in of p96 fully rescues endocytosis and embryonic viability, while p67 only partially rescues. Isoform-specific knock-in mice, endocytosis assays (transferrin/cubilin uptake), embryonic viability scoring Journal of cell science High 16263760
2005 In renal proximal tubule, Dab2 co-localizes with megalin in clathrin-coated pits/vesicles; megalin knockout nearly abolishes Dab2 staining (Dab2 localization requires megalin), and Dab2 knockout redistributes megalin from endosomes to microvilli with decreased total megalin protein. Introduction of anti-Dab2 antibody into BN16 cells decreased internalization of receptor-associated protein. Immunohistochemistry, megalin/Dab2 conditional knockout mice, immunoblotting, intracellular antibody injection, 125I-RAP internalization assay American journal of physiology. Renal physiology High 15870384
2009 Dab2 mediates bulk endocytosis of inactive integrins beta1, alpha1, alpha2, and alpha3 (but not alpha5 or alphav) into coated pits; Dab2 depletion inhibits cell migration and polarized recycling of integrin beta1 to the leading edge, and migration speed correlates with intracellular integrin pool size. Quantitative glycoprotein surface proteomics (SILAC), siRNA depletion, fluorescence microscopy, integrin beta1 surface/intracellular level manipulation, migration assay The Journal of cell biology High 19581412
2009 Dab2 attenuates Wnt/beta-catenin signaling by binding to Axin and acting as a competitive inhibitor of PP1, preventing PP1-mediated dephosphorylation and destabilization of Axin. The N-terminal PTB domain of Dab2 is sufficient to block PP1-Axin interactions; Dab2 overexpression in zebrafish phenocopies Axin overexpression. Co-immunoprecipitation, in vitro binding competition assay, Dab2 truncation mutants, beta-catenin reporter assay, Dab2 ectopic expression in zebrafish embryos Oncogene High 19581931
2007 Dab2 interacts with Axin and prevents Axin's interaction with and degradation by LRP5/6 Wnt co-receptor, thereby increasing Axin half-life and stabilizing the beta-catenin destruction complex to inhibit Wnt signaling. Co-immunoprecipitation, Axin half-life assay, beta-catenin reporter assay, F9 and mammary cell differentiation models Oncogene High 17922036
2012 Dab2 selectively recruits LRP6 to the clathrin-dependent endocytic pathway upon CK2-mediated phosphorylation of LRP6 at S1579, sequestering LRP6 from caveolin-dependent endocytosis required for Wnt signaling. LRP6-S1579A mutant fails to bind Dab2, escapes clathrin routing, and is insensitive to Dab2-mediated Wnt inhibition. Co-immunoprecipitation, site-directed mutagenesis (LRP6-S1579A), clathrin/caveolin endocytosis assays, Wnt reporter assay, zebrafish dorsoventral patterning, allograft mouse tumor model The EMBO journal High 22491013
2010 TGFbeta induces phosphorylation of hnRNP E1 at Ser43 by PKBbeta/Akt2, releasing hnRNP E1 from the 33-nucleotide BAT element in the 3'UTR of Dab2 (and ILEI) mRNAs, thereby relieving translational repression and inducing Dab2 protein expression as part of a post-transcriptional EMT regulon. RNA-protein binding assay, phospho-specific immunoblot, siRNA modulation of hnRNP E1, Akt2 kinase assay, translation reporter assay Nature cell biology High 20154680
2010 Dab2 knockdown does not affect internalization of TGFbeta, LDL, or transferrin but abrogates TGFbeta receptor recycling from early endosomes to the recycling compartment, resulting in enlarged EEA1-positive endosomes and diminished Smad2 phosphorylation. siRNA knockdown, endosome morphology (EEA1 immunofluorescence), receptor recycling assay, Smad2 phosphorylation assay Molecular biology of the cell High 20881059
2002 DOC-2/DAB2 interacts with DIP1/2, a novel GTPase-activating protein with a Ras GAP homology domain, via the N-terminal domain of DOC-2/DAB2; this complex is detected in normal brain and prostate. DIP1/2 expression blocks mitogen-induced gene expression and inhibits prostate cancer cell growth. Yeast two-hybrid cloning, co-immunoprecipitation from tissue lysates, cell growth assay The Journal of biological chemistry Medium 11812785
2002 DOC-2/DAB2 proline-rich domain interacts with the SH3 domain of c-Src; this binding is enhanced by growth factor and results in c-Src inactivation (decreased pTyr416) and reduced downstream effector activity. Co-immunoprecipitation, c-Src kinase activity assay (pTyr416), growth factor stimulation The Journal of biological chemistry Medium 12473651
2001 DOC-2/hDab-2 expression in breast cancer cells induces anoikis associated with down-regulation of integrin-linked kinase (ILK) activity, suggesting Dab2 negatively regulates the ILK anti-apoptotic pathway. Transfection, suspension-induced cell death (anoikis) assay, ILK kinase activity assay Oncogene Medium 11687976
2003 Dab2 associates with CIN85 via its PKPAPR motif in the C-terminus, recruiting CIN85 to the clathrin coat; growth factor stimulation dissociates Dab2 and clathrin from CIN85, enabling Cbl to bind CIN85 during receptor tyrosine kinase endocytosis. Co-immunoprecipitation, peptide binding assay, growth factor stimulation time-course FEBS letters Medium 14596919
2009 The p82 isoform of Dab2 induces enlarged clathrin assemblies at the plasma membrane dependent on a functional PTB domain, clathrin binding, phospholipid binding, and a poly-lysine stretch preceding the PTB domain; p82 expression also enhances cell spreading on fibronectin and concentrates beta1 integrin into clathrin-p82 assemblies. GFP-fusion expression, live-cell imaging, FRAP, clathrin assembly morphology, site-directed mutagenesis, fibronectin spreading assay The Biochemical journal High 19000037
2010 Dab2 is progressively displaced from the plasma membrane and loses co-localization with clathrin during mitosis, peaking at metaphase/anaphase; this displacement is accompanied by Dab2 phosphorylation, reduced Dab2-clathrin interactions, decreased endocytic vesicle motility, and impaired internalization of NPXY-containing cargo. Ser/Thr-to-Ala mutations in the central region of Dab2 attenuate its phosphorylation and membrane displacement, maintaining endocytic activity during mitosis. Live-cell imaging, immunofluorescence, FRAP, co-immunoprecipitation, NPXY-cargo internalization assay, site-directed mutagenesis (Ser/Thr→Ala), pharmacological mitotic arrest (2-methoxyestradiol) The Journal of biological chemistry High 21097498
2012 Dab2 binds Eps15 and intersectin via its EH-domain binding sites; mutation of these sites impairs integrin beta1 endocytosis (but not transferrin receptor) without displacing Dab2 from clathrin structures, indicating that Dab2-mediated recruitment of EH domain proteins selectively drives internalization of Dab2 cargo. Co-immunoprecipitation, site-directed mutagenesis (EH-binding site mutants), integrin beta1 and transferrin endocytosis assay, clathrin structure analysis Molecular biology of the cell High 22648170
2012 Dab2 depletion in airway epithelial cells inhibits CFTR endocytosis and post-endocytic trafficking from sorting endosome to recycling compartment and to late endosome, resulting in increased CFTR half-life (~3-fold); this is distinct from AP-2 depletion which primarily reduces endocytosis without affecting CFTR stability. siRNA depletion of Dab2 vs. AP-2, CFTR surface biotinylation, endocytosis assay, recycling assay, protein half-life measurement The Biochemical journal High 21995445
2014 Dab2 interacts with TGFbeta type I receptor (TbetaRI), restricts its lateral diffusion at the plasma membrane, and enhances clathrin-mediated endocytosis of TbetaRI; Dab2 negatively regulates TGFbeta-induced JNK activation but not Smad pathway activation. JNK activation by TGFbeta in the absence of Dab2 is disrupted by cholesterol depletion, indicating TbetaRI localizes to cholesterol-rich domains when Dab2 is absent. Biophysical lateral diffusion measurements (SPT/FRAP), siRNA knockdown and overexpression, JNK and Smad phosphorylation assays, cholesterol depletion Molecular biology of the cell High 24648493
2018 In endothelial cells, Dab2 recruitment to the apoER2 NPXY motif promotes activating L309 methylation of the PP2A catalytic subunit by LCMT-1; simultaneously, SHC1 recruits the PP2A scaffolding subunit to the proline-rich apoER2 C-terminus, forming a PP2A holoenzyme that dephosphorylates (inactivates) Akt and eNOS, mediating antiphospholipid antibody-induced thrombosis. Co-immunoprecipitation, PP2A methylation assay, Akt/eNOS phosphorylation assays, mouse thrombosis model with endothelial-specific manipulation Blood High 29500169
2005 ApoER2 internalizes via clathrin-mediated endocytosis through its cytoplasmic FxNPXY motif binding to Dab2; dominant-negative Dab2 and eps15 reduce apoER2 internalization, whereas blocking caveolar/raft pathway (nystatin) has no effect. Raft association of apoER2 does not determine its endocytic route. Dominant-negative Dab2 and eps15 expression, nystatin treatment, apoER2 internalization assay, mutagenesis of FxNPXY motif Traffic (Copenhagen, Denmark) High 16101684
2010 Amnionless (AMN) FXNPXF motifs in cubam receptor mediate endocytosis through direct interaction with Dab2 and ARH; the two signals are functionally redundant, demonstrated by sequential mutation and yeast two-hybrid analyses. Yeast two-hybrid, amnionless mutant expression panel, endocytosis assay Traffic (Copenhagen, Denmark) Medium 20088845
2014 ARH and Dab2 both bind LDLR but not NPC1L1, and are not required for NPC1L1 internalization; Numb specifically binds NPC1L1 and mediates cholesterol absorption, distinctly from ARH and Dab2 which selectively participate in LDLR-mediated LDL uptake. Co-immunoprecipitation, siRNA knockdown, LDL and cholesterol uptake assays, domain-specific PTB binding studies The Journal of biological chemistry High 25331956
2012 Akt/PKB interacts with the proline-rich domain (PRD) of Dab2 via its PH and catalytic domains, and phosphorylates Dab2 at Ser448 and Ser449; Ser-to-Ala mutations at these sites inhibit albumin endocytosis and shift Dab2 localization from peripheral to perinuclear compartment, demonstrating that Akt-mediated Dab2 phosphorylation is required for albumin endocytosis. Co-immunoprecipitation, GST pull-down with truncated constructs, yeast two-hybrid, Akt isoform-specific siRNA, Dab2 Ser448/449Ala mutagenesis, albumin endocytosis assay, Dab2 localization imaging American journal of physiology. Renal physiology High 22218591 25253241
2009 Dab2 is a FOXP3 target gene exclusively expressed in FOXP3+ regulatory T cells; regulatory T cells lacking Dab2 are functionally impaired in vitro and in vivo (suppressive capacity), but Dab2 is dispensable for Treg-mediated naive T cell homeostasis. Flow cytometry, genetic KO of Dab2 in Tregs, in vitro suppression assay, in vivo adoptive transfer Journal of immunology High 19767570
2016 DAB2 loss in zebrafish (CRISPR/Cas9 KO) reduces cardiomyocyte number and increases WNT/beta-catenin signaling; these defects are suppressed by DKK1 overexpression, placing DAB2 upstream of WNT signaling in cardiac development. CRISPR/Cas9 knockout in zebrafish, cardiomyocyte counting, WNT/beta-catenin signaling assay, DKK1 rescue experiment, label-free quantitative proteomics in human ESC differentiation Proceedings of the National Academy of Sciences of the United States of America High 26755607
2016 Combined deletion of Dab2 and Arh in mice results in profound hypercholesterolemia similar to LDLR knockout; in liver, Dab2 is expressed in sinusoidal endothelial cells (not hepatocytes) and in the absence of Arh, Dab2 in liver endothelial cells regulates cholesterol synthesis (HMG-CoA reductase levels) in hepatocytes. Double KO mice (arh/dab2), serum cholesterol measurement, HMG-CoA reductase western blot, cell-type-specific immunostaining Journal of lipid research High 27005486
2019 DAB2 expression in dendritic cells is rapidly downregulated by TLR ligands in a TRIF- and MyD88-dependent biphasic manner (rapid protein drop then sustained mRNA reduction); DAB2 knockdown promotes activated DC phenotype (increased IL-12, IL-6, CD40), reduces phagocytosis, and Dab2-KO DCs inhibit autophagy and promote apoptotic cell death. BMDC TLR stimulation, siRNA/KO, qPCR, flow cytometry, cytokine ELISA, autophagy assay, TRIF/MyD88 pathway analysis Frontiers in immunology High 30873168
2021 Dab2 myosin interacting region (MIR) binds myosin VI with moderate affinity (Kd ~184 nM) and high turnover rate (~1 s-1); dynamic (not stable) multimerization of Dab2-MIR/myosin VI complexes promotes cargo processivity on actin while preserving cortical actin network integrity. Constitutive stable dimers cause actin reorganization and foci formation. Single-molecule kinetics, in vitro motility assay, DNA origami scaffold-based cargo mimetics, minimal actin cortex assay on lipid bilayers, fluorescence microscopy The Journal of biological chemistry High 33372034
2008 DAB2 silencing in human endothelial cells activates Src-FAK signaling, ERK and JNK activation, inhibits p38 phosphorylation, and promotes cell proliferation/migration while impairing capillary-like morphogenesis; pharmacological Src inhibition (PP2) abolishes FAK activation and restores endothelial differentiation. Lentiviral shRNA knockdown, Src/FAK phosphorylation assay, ERK/JNK/p38 immunoblot, endothelial tube formation assay, PP2 pharmacological rescue FEBS letters Medium 18582465
2024 HDAC5 deacetylates H3K9ac at the DAB2 promoter, repressing DAB2 expression; A. muciniphila inhibits HDAC5, thereby increasing DAB2 expression, which blocks macrophage pro-inflammatory M1 polarization. DAB2 overexpression reverses HDAC5-induced pro-inflammatory polarization. ChIP for H3K9ac, siRNA/overexpression of HDAC5 and DAB2, macrophage polarization assay, in vivo DSS colitis model with A. muciniphila treatment Biochimica et biophysica acta. Molecular cell research Medium 38776988
2000 GATA-6 (but not GATA-4) transcriptionally activates the Dab2 promoter in visceral endoderm; GATA-6-null ES cells lack Dab2 expression, and forced GATA-6 expression in NIH-3T3 cells transactivates the human Dab2 promoter. The specificity is not mediated through GATA-6's zinc finger DNA-binding domain. Subtractive hybridization, in vivo GATA-6 KO embryos, co-transfection reporter assay, GATA-4 KO embryos as negative control The Journal of biological chemistry Medium 10779506
2023 In kidney proximal tubule cells, megalin, cubilin/amnionless (CUBAM), and Dab2 each have distinct roles in albumin endocytosis and endocytic pathway flux; CRISPR KO of each component has different effects on albumin uptake concentration-dependence and intracellular distribution, but key endocytic pathway proteins are preserved in all KOs, indicating these components drive endocytic flux without compromising pathway integrity. CRISPR/Cas9 KO in differentiated proximal tubule cell line, albumin internalization assay, fluid-phase marker uptake, confocal imaging, megalin KO mice Molecular biology of the cell High 37126375

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nature cell biology 265 20154680
2002 Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic (Copenhagen, Denmark) 204 11967127
2002 Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. The EMBO journal 170 11927540
2006 The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. Journal of cell science 147 16984970
1998 DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. Oncogene 143 9620555
2002 The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. The Journal of biological chemistry 128 11812785
2000 Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. The Biochemical journal 123 10769163
2005 Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). The Journal of biological chemistry 114 15734730
2003 Regulation of the Wnt signaling pathway by disabled-2 (Dab2). The EMBO journal 114 12805222
1998 Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene 109 9569023
2004 Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 102 15041729
2009 Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. The Journal of cell biology 101 19581412
2005 Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway. The Journal of biological chemistry 98 15894542
2001 The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. The Journal of biological chemistry 92 11371563
2005 Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers. International journal of cancer 90 15386433
2005 Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. Journal of cell science 90 16263760
1998 Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Endocrinology 88 9681506
2005 Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. American journal of physiology. Renal physiology 83 15870384
2000 The gene encoding the mitogen-responsive phosphoprotein Dab2 is differentially regulated by GATA-6 and GATA-4 in the visceral endoderm. The Journal of biological chemistry 77 10779506
1998 DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases. Oncogene 77 9696034
2013 miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene 71 24037530
2012 Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin. The EMBO journal 70 22491013
2005 Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour. British journal of cancer 69 15770214
2018 Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. Blood 66 29500169
2005 ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (Copenhagen, Denmark) 63 16101684
2002 Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. The Journal of biological chemistry 61 12473651
2010 Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma. BMC cancer 55 20525238
1999 The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer. The Journal of biological chemistry 54 10542228
2010 Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2. Molecular biology of the cell 51 20881059
2005 The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer. Cancer research 51 16267015
2016 Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling. Proceedings of the National Academy of Sciences of the United States of America 47 26755607
2012 The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis. Molecular biology of the cell 47 22648170
2001 DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway. Oncogene 47 11687976
2010 AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2. Traffic (Copenhagen, Denmark) 46 20088845
2007 Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Clinical cancer research : an official journal of the American Association for Cancer Research 44 17671122
2006 Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancer. Breast cancer research and treatment 44 17115114
2009 Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene 43 19581931
2009 Dab2 regulates clathrin assembly and cell spreading. The Biochemical journal 42 19000037
2007 The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin. Oncogene 42 17922036
1996 Sequence, genomic structure, and chromosomal assignment of human DOC-2. Genomics 42 8660969
2024 DAB2 + macrophages support FAP + fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer. Theranostics 40 39239526
2002 Down-regulation of DOC-2 in colorectal cancer points to its role as a tumor suppressor in this malignancy. Diseases of the colon and rectum 40 12352243
2019 miR-1307-3p promotes tumor growth and metastasis of hepatocellular carcinoma by repressing DAB2 interacting protein. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 39 31176165
2013 Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues. BMC developmental biology 37 24168030
2012 Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator. The Biochemical journal 37 21995445
1997 Cloning and sequencing of complement component C9 and its linkage to DOC-2 in the pufferfish Fugu rubripes. Gene 36 9373156
2018 MiR-93 functions as a tumor promoter in prostate cancer by targeting disabled homolog 2 (DAB2) and an antitumor polysaccharide from green tea (Camellia sinensis) on their expression. International journal of biological macromolecules 35 30543885
2012 PKB/Akt partners with Dab2 in albumin endocytosis. American journal of physiology. Renal physiology 35 22218591
2020 Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation. Frontiers in immunology 34 33178208
2017 Substrate stiffness affects epithelial-mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2. International journal of oncology 34 28498390
2003 Dab2 links CIN85 with clathrin-mediated receptor internalization. FEBS letters 33 14596919
2017 miR-191/DAB2 axis regulates the tumorigenicity of estrogen receptor-positive breast cancer. IUBMB life 32 29247596
2014 The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake. The Journal of biological chemistry 32 25331956
2019 miR-134-5p Promotes Stage I Lung Adenocarcinoma Metastasis and Chemoresistance by Targeting DAB2. Molecular therapy. Nucleic acids 30 31689617
2015 Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy. Oncoimmunology 30 25949867
2015 ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments. PloS one 29 25879443
2020 Epstein-Barr virus miR-BART1-3p suppresses apoptosis and promotes migration of gastric carcinoma cells by targeting DAB2. International journal of biological sciences 28 32025216
2013 Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis. Acta neuropathologica communications 28 24252604
2010 Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. The Journal of biological chemistry 28 21097498
2009 Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function. Journal of immunology (Baltimore, Md. : 1950) 28 19767570
2000 Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2). Genomics 28 11161789
2023 Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells. Molecular biology of the cell 27 37126375
2016 Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. Journal of lipid research 26 27005486
2023 LncRNA MEG3 Inhibits Tumor Progression by Modulating Macrophage Phenotypic Polarization via miR-145-5p/DAB2 Axis in Hepatocellular Carcinoma. Journal of hepatocellular carcinoma 25 37435155
2021 Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells. American journal of physiology. Renal physiology 25 34747197
2014 Frequent loss expression of dab2 and promotor hypermethylation in human cancers: a meta-analysis and systematic review. Pakistan journal of medical sciences 25 24772157
2014 Akt recruits Dab2 to albumin endocytosis in the proximal tubule. American journal of physiology. Renal physiology 25 25253241
2014 Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β. Molecular biology of the cell 24 24648493
2001 Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis. Laboratory investigation; a journal of technical methods and pathology 24 11406647
2019 Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells. Frontiers in immunology 23 30873168
2012 Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1/DAB2 axis. Clinical cancer research : an official journal of the American Association for Cancer Research 22 22753593
2008 Dynamic expression of Dab2 in the mouse embryonic central nervous system. BMC developmental biology 22 18680569
2006 Inhibition of mitogen-elicited signal transduction and growth in prostate cancer with a small peptide derived from the functional domain of DOC-2/DAB2 delivered by a unique vehicle. Cancer research 22 16982733
2022 Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic Pathways. International journal of molecular sciences 21 36614139
2018 miR-106b targets DAB2 to promote hepatocellular carcinoma cell proliferation and metastasis. Oncology letters 21 30127897
2014 Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling. Neural regeneration research 21 25206742
2008 Morphogenesis of human endothelial cells is inhibited by DAB2 via Src. FEBS letters 21 18582465
2012 Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells. Experimental cell research 19 22265793
2006 Xenopus Dab2 is required for embryonic angiogenesis. BMC developmental biology 19 17176484
2017 RETRACTED: miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 18 28837878
2020 The role of disabled-2 (Dab2) in diseases. Gene 17 33059028
2017 RNF5, DAB2 and Friends: Novel Drug Targets for Cystic Fibrosis. Current pharmaceutical design 17 27719636
2018 Deficiency of Dab2 (Disabled Homolog 2) in Myeloid Cells Exacerbates Inflammation in Liver and Atherosclerotic Plaques in LDLR (Low-Density Lipoprotein Receptor)-Null Mice-Brief Report. Arteriosclerosis, thrombosis, and vascular biology 16 29599136
2020 Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder. Diagnostics (Basel, Switzerland) 15 31968685
2012 Tissue-specific control of CFTR endocytosis by Dab2: Cargo recruitment as a therapeutic target. Communicative & integrative biology 15 23181163
2020 miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. The American journal of pathology 14 31953039
2020 (-)-Epigallocatechin Gallate Promotes MicroRNA 145 Expression against Myocardial Hypoxic Injury through Dab2/Wnt3a/-catenin. The American journal of Chinese medicine 14 32138537
2020 DAB2 suppresses gastric cancer migration by regulating the Wnt/β-catenin and Hippo-YAP signaling pathways. Translational cancer research 14 35117462
2018 miR‑149 promotes the myocardial differentiation of mouse bone marrow stem cells by targeting Dab2. Molecular medicine reports 14 29693140
2016 Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight. Scientific reports 14 27072056
2014 Dab2, megalin, cubilin and amnionless receptor complex might mediate intestinal endocytosis in the suckling rat. Journal of cellular biochemistry 14 24122887
2024 Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia. Cellular and molecular life sciences : CMLS 13 38613672
2024 Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis. Biochimica et biophysica acta. Molecular cell research 13 38776988
2018 Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease. Investigative ophthalmology & visual science 13 30267088
2015 Aberrant Hypermethylation at Sites -86 to 226 of DAB2 Gene in Non-Small Cell Lung Cancer. The American journal of the medical sciences 13 25719979
2014 Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-β and induce Tregs development via TGF-β. PloS one 13 24638085
2012 Association of the variant rs2243421 of human DOC-2/DAB2 interactive protein gene (hDAB2IP) with gastric cancer in the Chinese Han population. Gene 12 23246699
2021 Dynamic multimerization of Dab2-Myosin VI complexes regulates cargo processivity while minimizing cortical actin reorganization. The Journal of biological chemistry 11 33372034
2021 MicroRNA‑93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2. International journal of oncology 11 34476495
2017 DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway. Oncology reports 11 28586035

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