Affinage

CNN2

Calponin-2 · UniProt Q99439

Length
309 aa
Mass
33.7 kDa
Annotated
2026-04-28
57 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CNN2 (calponin 2/h2-calponin) is an actin filament-associated regulatory protein that controls stress fiber organization, cell contractility, migration, and phagocytosis across diverse cell types including macrophages, endothelial cells, fibroblasts, and smooth muscle cells (PMID:18617524, PMID:16317011, PMID:27733037, PMID:41796654). Mechanistically, CNN2 stabilizes actomyosin bundles by controlling α-actinin distribution along stress fibers rather than by directly inhibiting myosin II, and its loss reduces stress fiber thickness, increases fragility, and alters traction force generation (PMID:41297546, PMID:27733037). CNN2 is a direct substrate of the CRL3-gigaxonin E3 ubiquitin ligase for proteasomal turnover, and during lysophagy it translocates to damaged lysosomes where it must be ubiquitylated and extracted by VCP/p97-HSPB1 to promote phagophore formation (PMID:37903270, PMID:35793674). A de novo CNN2 missense variant (p.N7S) causes intestinal pseudo-obstruction through impaired smooth muscle contractility, establishing CNN2 as a disease gene for this condition (PMID:41796654).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2005 High

    The question of whether CNN2 functions in vascular development was answered: CNN2 is required for endothelial cell migration during intersegmental vessel formation, acting via MAPK pathway activation, establishing an in vivo developmental role beyond smooth muscle.

    Evidence Zebrafish morpholino knockdown blocking vessel formation, HUVEC knockdown/overexpression with MAPK inhibitor

    PMID:16317011

    Open questions at the time
    • Precise MAPK substrates linking CNN2 to migration not identified
    • Whether CNN2 acts cell-autonomously in endothelial cells versus surrounding cells not fully resolved
  2. 2008 High

    Whether CNN2 operates in immune cells was unknown; Cnn2 knockout mice revealed that CNN2 negatively regulates macrophage motility and phagocytosis while promoting spreading and tropomyosin incorporation into the actin cytoskeleton, defining CNN2 as a cytoskeletal brake in myeloid cell function.

    Evidence Cnn2 global KO mouse, macrophage migration/phagocytosis/spreading assays, cytoskeletal fractionation

    PMID:18617524

    Open questions at the time
    • Direct actin-binding site requirements for macrophage phenotypes not mapped
    • Whether CNN2 regulates phagocytic receptor clustering or purely actin dynamics unclear
  3. 2013 High

    The signaling pathway upstream of CNN2 in cell migration was unclear; genetic epistasis showed CNN2 functions downstream of Wnt/PCP-RhoA signaling to regulate polarized actin protrusions during neural crest cell migration.

    Evidence Morpholino knockdown in Xenopus and chick embryos, epistasis with dominant-negative Wnt11 and RhoA inhibition

    PMID:23499442

    Open questions at the time
    • Direct phosphorylation or activation mechanism by RhoA effectors not established
    • Whether Wnt/PCP-CNN2 axis operates in other migratory cell types unknown
  4. 2016 High

    Three studies collectively established the mechanobiological principle that CNN2 restrains myosin II-dependent traction force and inflammatory cell functions: Cnn2 KO fibroblasts generate greater traction force independently of myosin II, while myeloid-specific Cnn2 KO attenuates atherosclerosis and inflammatory arthritis by reducing macrophage adhesion, cytokine production, and osteoclastogenesis.

    Evidence CTF microscopy on KO fibroblasts with blebbistatin, conditional myeloid KO in ApoE-/- atherosclerosis and anti-GPI arthritis models

    PMID:27488671 PMID:27575021 PMID:27733037

    Open questions at the time
    • Molecular mechanism by which CNN2 limits traction force independently of myosin II not resolved at this time
    • Whether CNN2's adhesion-regulating role is integrin-specific not determined
  5. 2018 High

    The question of whether CNN2 acts exclusively in macrophages in cardiovascular disease was answered: systemic but not myeloid-specific Cnn2 KO reduced valve calcification in CAVD, revealing a non-macrophage role of CNN2 in TGFβ1-induced myofibroblast differentiation.

    Evidence Systemic vs. myeloid-specific Cnn2 KO in ApoE-/- mice, in vitro myofibroblast differentiation and calcification assays

    PMID:30053524

    Open questions at the time
    • The specific non-macrophage cell type (valvular interstitial cell vs. other) not definitively resolved
    • Whether CNN2 directly modulates TGFβ receptor signaling or only downstream actin remodeling unclear
  6. 2022 High

    CNN2's role in selective autophagy was unknown; it was discovered that CNN2 translocates to damaged lysosomes upon membrane permeabilization to nucleate Arp2/3-dependent actin assembly for phagophore formation, with its subsequent ubiquitylation and VCP/p97-HSPB1-mediated extraction required for lysophagy progression.

    Evidence Ubiquitylated proteome profiling upon LMP, Co-IP, live imaging of CNN2 translocation, VCP/p97 inhibition functional assay

    PMID:35793674

    Open questions at the time
    • The E3 ligase responsible for CNN2 ubiquitylation during lysophagy not identified in this study
    • Whether CNN2 is recycled or degraded after extraction unknown
    • Structural basis of CNN2-Arp2/3 cooperation not resolved
  7. 2023 High

    Multiple discoveries in 2023 expanded CNN2's roles beyond cytoskeletal mechanics: CNN2 interacts with ESR2 to suppress fatty acid oxidation (via PPARα) in kidney fibrosis and ketogenesis (via SIRT5-HMGCS2) in acute kidney injury; CNN2 is a direct CRL3-gigaxonin substrate for proteasomal degradation; CNN2 forms a YAP1-EGR1 complex stabilizing EGR1 in colorectal cancer; and CNN2 is a functional SRF target maintaining hair cell stereocilia and cuticular plate integrity.

    Evidence Co-IP/ChIP for CNN2-ESR2-PPARα and CNN2-ESR2-SIRT5 axes in kidney models; in vitro ubiquitination and gigaxonin Kelch domain mutagenesis; Co-IP of CNN2-YAP1-EGR1 with xenograft; hair cell Srf KO with AAV-CNN2 rescue

    PMID:36963615 PMID:37188478 PMID:37751293 PMID:37903270 PMID:37982489

    Open questions at the time
    • How a cytoskeletal protein physically modulates ESR2-dependent transcription is mechanistically unclear
    • Whether gigaxonin-mediated CNN2 turnover connects to the lysophagy-specific ubiquitylation unknown
    • YAP1-EGR1 complex stoichiometry and CNN2's scaffolding mechanism not structurally resolved
  8. 2025 High

    The longstanding model that CNN2 inhibits myosin II was overturned: systematic isoform depletion with super-resolution imaging showed CNN2 instead controls α-actinin distribution along actomyosin bundles, regulating stress fiber thickness and integrity rather than myosin motor activity directly.

    Evidence Individual and collective CNN isoform depletion in U2OS cells, super-resolution imaging of α-actinin periodicity, cell migration assay

    PMID:41297546

    Open questions at the time
    • Binding interface between CNN2 and α-actinin not structurally resolved
    • Whether the α-actinin-organizing function accounts for all previously observed cellular phenotypes untested
  9. 2025 High

    A de novo CNN2 missense variant (p.N7S) was shown to cause intestinal pseudo-obstruction through impaired smooth muscle contractility in a knock-in mouse, establishing CNN2 as a Mendelian disease gene.

    Evidence CRISPR/Cas9 Cnn2-N7S knock-in mice, GI transit assay, collagen gel contraction in primary intestinal smooth muscle cells

    PMID:41796654

    Open questions at the time
    • Only a single family reported; replication in additional patients needed
    • Structural consequence of N7S on CNN2 actin-binding or α-actinin-organizing function not determined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how CNN2's actin-organizing activity is mechanistically coupled to its nuclear/transcriptional roles (ESR2, YAP1-EGR1 interactions), whether distinct ubiquitylation events by CRL3-gigaxonin versus lysophagy-associated E3 ligases serve different physiological contexts, and no high-resolution structure of CNN2 in complex with α-actinin or actin filaments exists.
  • No structural model of CNN2 on actin filaments
  • Nuclear versus cytoplasmic pools of CNN2 not characterized
  • Isoform-specific versus redundant functions of CNN1/2/3 in vivo not systematically tested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 7 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 6 GO:0005829 cytosol 2 GO:0005764 lysosome 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-1430728 Metabolism 2 R-HSA-162582 Signal Transduction 2 R-HSA-392499 Metabolism of proteins 1 R-HSA-9612973 Autophagy 1
Partners
ACTN1EGR1ESR2GANHSPB1VCPYAP1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CNN2 (h2-calponin) is expressed in peripheral blood myeloid cells and acts as an actin cytoskeleton regulator in macrophages; Cnn2 knockout mice showed reduced peripheral blood neutrophils and monocytes, and Cnn2-null macrophages exhibited higher proliferation rates, faster migration, reduced spreading with decreased tropomyosin in the actin cytoskeleton, and significantly increased phagocytic activity, establishing CNN2 as a negative regulator of macrophage motility and phagocytosis. Cnn2 gene knockout mouse model (loxP/Cre and FLP recombinase system), cell migration assays, phagocytosis assays, cytoskeletal fractionation The Journal of biological chemistry High 18617524
2005 CNN2 is required for endothelial cell migration during vascular development; morpholino knockdown of calponin 2 in zebrafish blocked proper endothelial cell migration during intersegmental vessel formation, and in vitro knockdown in HUVECs reduced bFGF-induced migration while overexpression enhanced migration, with the pro-migratory effect dependent on MAPK pathway activation. Zebrafish morpholino knockdown, antisense adenovirus knockdown in HUVECs, wound healing assay, MAPK inhibition The Journal of biological chemistry High 16317011
2013 CNN2 acts as an effector downstream of noncanonical Wnt/PCP signaling to regulate actin dynamics during neural crest cell migration; Cnn2 knockdown caused randomized cell protrusions and central stress fibers at the expense of the peripheral actin network, and migration defects induced by dominant-negative Wnt11 or RhoA inhibition were rescued by Cnn2 knockdown, placing CNN2 downstream of Wnt/PCP-RhoA in controlling polarized actin protrusions. Morpholino knockdown in Xenopus and chick embryos, NCC explant protrusion assays, epistasis via dominant-negative Wnt11 and RhoA inhibition Cell reports High 23499442
2016 Deletion of CNN2 in macrophages increases migration velocity of foam cells, attenuates pro-inflammatory cytokine production, weakens cell adhesion, and reduces macrophage infiltration, thereby attenuating the development of arterial atherosclerosis lesions in ApoE knockout mice; myeloid cell-specific Cnn2 KO recapitulated these effects, demonstrating a cytoskeleton-based mechanism in inflammatory disease. Systemic and myeloid cell-specific Cnn2 KO mice crossed with ApoE KO mice, macrophage migration and adhesion assays, cytokine quantification Journal of molecular and cellular cardiology High 27575021
2016 Deletion of Cnn2 in macrophages attenuates inflammatory arthritis and reduces osteoclastogenesis; Cnn2-null bone marrow cells produced fewer osteoclasts with decreased bone resorption, and conditional myeloid-specific Cnn2 KO confirmed attenuation of arthritis, implicating CNN2 cytoskeletal regulation in osteoclast function and inflammatory bone erosion. Systemic and conditional myeloid-specific Cnn2 KO mice, anti-GPI serum-induced arthritis model, in vitro osteoclast differentiation assay, bone resorption assay American journal of physiology. Cell physiology High 27488671
2016 Knockout of Cnn2 in mouse fibroblasts increases myosin II-dependent cell traction force (CTF); Cnn2-null fibroblasts showed greater root-mean-square traction and total strain energy, faster de-adhesion, and the myosin II inhibitor blebbistatin had an additive effect only when calponin 2 was present, demonstrating that CNN2 and myosin II act independently but additively to regulate contractile force. Cnn2 KO mouse fibroblasts, CTF microscopy on polyacrylamide gel with fluorescent beads, blebbistatin inhibition assay Biochemistry High 27733037
2013 CNN2 is an androgen-responsive SRF target gene in prostate cancer; siRNA-mediated loss of CNN2 did not affect proliferation or apoptosis but induced cellular protrusions and increased CaP cell migration correlated with altered β1-integrin expression, demonstrating a role for CNN2 in actin cytoskeleton organization and cell migration downstream of AR-SRF signaling. siRNA knockdown, cell migration assay, actin cytoskeleton staining, β1-integrin Western blot Carcinogenesis Medium 23576568
2018 Systemic or myeloid cell-specific Cnn2 KO attenuates calcific aortic valve disease in ApoE KO mice; CNN2 participates in TGFβ1-induced myofibroblast differentiation as shown by lower SMA expression and less calcification in Cnn2-null cells versus wild type, but myeloid-specific Cnn2 KO did not reduce valve calcification, distinguishing a non-macrophage cell-type-specific role of CNN2 in CAVD. Systemic and myeloid-specific Cnn2 KO in ApoE KO mice, in vitro myofibroblast differentiation assay, SMA and calcification quantification Journal of molecular and cellular cardiology High 30053524
2022 CNN2 translocates to damaged lysosomes upon lysosomal membrane permeabilization (LMP) together with the Arp2/3 complex to regulate actin filaments and drive phagophore formation during lysophagy; CNN2 must be ubiquitylated during this process and then extracted by VCP/p97 (assisted by HSPB1) for efficient lysophagy to proceed. Ubiquitylated proteome profiling upon LMP, Co-IP/pulldown, live imaging of CNN2 translocation to damaged lysosomes, functional lysophagy assay with VCP/p97 inhibition Molecular cell High 35793674
2023 CNN2 knockdown in fibrotic kidneys enhances fatty acid oxidation (FAO) by upregulating key rate-limiting FAO enzymes; mechanistically, CNN2 interacts with estrogen receptor 2 (ESR2), which binds PPARα to transcriptionally regulate FAO gene expression, and PPARα activation reduced CNN2-induced matrix deposition, linking CNN2-mediated actin mechanics to metabolic reprogramming in kidney fibrosis. Cnn2 knockdown mouse models (ischemia-reperfusion, unilateral ureteral obstruction), global proteomics, chromatin immunoprecipitation (ChIP), Co-IP (CNN2-ESR2 interaction), in vitro ESR2 and PPARα manipulation Molecular metabolism High 36963615
2023 CNN2 interacts with ESR2 to negatively regulate mitochondrial sirtuin 5 activity during acute kidney injury; activated sirtuin 5 desuccinylates HMGCS2 (a rate-limiting ketogenesis enzyme), increasing ketone body β-hydroxybutyrate and ATP production to mitigate AKI, distinct from the FAO pathway regulated by CNN2 in fibrosis. CNN2 knockdown mouse AKI models (ischemia-reperfusion), proteomics, Co-IP (CNN2-ESR2-SIRT5 axis), HMGCS2 desuccinylation assay, β-hydroxybutyrate and ATP measurement JCI insight High 37751293
2023 CRL3gigaxonin E3 ubiquitin ligase directly targets CNN2 (along with TPM1, TPM2, and TAGLN) for proteasomal degradation, controlling actin filament regulatory proteins; gigaxonin mutations (L309R, R545C, C570Y) in the Kelch domain disrupt binding to these substrates, leading to their accumulation. In vitro ubiquitination assay, Co-IP (GIG-CNN2 binding), mutagenesis of GIG Kelch domain, proteasome inhibitor experiments Proceedings of the National Academy of Sciences of the United States of America High 37903270
2023 In colorectal cancer cells, CNN2 forms a complex with YAP1 and EGR1; CNN2 knockdown promotes ubiquitination of EGR1, reducing its protein stability in a YAP1-dependent manner and suppressing CRC cell growth and tumor formation. Co-IP (CNN2-YAP1-EGR1 complex), ubiquitination assay, gain- and loss-of-function experiments in vitro and in vivo xenograft Life science alliance Medium 37188478
2023 SRF transcriptionally regulates CNN2 expression in hair cells; AAV-mediated exogenous delivery of CNN2 in Srf-mutant mice partially rescued impaired stereocilia dimensions and F-actin intensity of the cuticular plate, demonstrating CNN2 as a functional downstream effector of the SRF pathway in regulating hair bundle morphology and cuticular plate actin cytoskeleton. Hair cell-specific Srf knockout mouse, AAV rescue (exogenous CNN2 delivery), fluorescence-activated cell sorting-based RNA-seq, stereocilia morphology analysis, F-actin intensity measurement eLife High 37982489
2024 Loss of calponin 2 (Cnn2 KO) causes premature ovarian insufficiency in mice; Cnn2-KO ovaries showed lower total follicle numbers, multi-oocyte follicles, and age-progressive follicle depletion; CNN2 colocalizes with actin stress fibers, tropomyosin, and myosin II in cumulus cells, establishing a role in ovarian folliculogenesis. Cnn2 KO mouse breeding analysis, ovarian follicle counting, immunofluorescence colocalization of CNN2 with actin/tropomyosin/myosin II in primary cumulus cell cultures Journal of ovarian research Medium 38336796
2024 TSA-induced muscle-derived extracellular vesicles enriched with miR-873-3p promote osteogenic differentiation in hBMSCs by targeting CNN2, as validated by functional assays showing that CNN2 knockdown in hBMSCs promotes osteogenesis. miRNA-target validation, shRNA knockdown of CNN2 in hBMSCs, osteogenic differentiation assay Signal transduction and targeted therapy Medium 39343927
2025 CNN2 is not a negative regulator of myosin II as previously suggested; instead, CNN2 (along with CNN1 and CNN3) controls the distribution of α-actinin along actomyosin bundles, regulating stress fiber thickness and integrity; loss of CNN2 reduces stress fiber thickness, increases fragility, and impairs cell migration in U2OS cells. Individual and collective depletion of CNN isoforms in U2OS cells, super-resolution microscopy of stress fibers, α-actinin distribution analysis, cell migration assay Current biology : CB High 41297546
2025 CNN2 suppresses metastasis in NSCLC by negatively regulating RSK2 expression; h2-calponin downregulation leads to activation of RSK2/HSP27/CREB signaling, promoting tumor migration and invasion, while h2-calponin upregulation reverses these effects; luciferase reporter assay showed CNN2 regulates RSK2 at the transcriptional level. siRNA knockdown and overexpression in NSCLC lines, wound healing and transwell assay, vein injection metastasis model, luciferase reporter assay, actin stress fiber staining Pathology, research and practice Medium 40700931
2026 A de novo CNN2 missense variant (p.N7S) causes intestinal pseudo-obstruction; Cnn2N7S/N7S knock-in mice showed significantly prolonged gastrointestinal transit time, and primary mouse intestinal smooth muscle cells bearing the variant exhibited impaired contractile function in a gene dosage-dependent manner, establishing CNN2 as a regulator of intestinal smooth muscle contractility. CRISPR/Cas9 knock-in mouse model, carmine red intestinal transit assay, collagen gel contraction assay in primary intestinal smooth muscle cells, Western blotting Journal of pediatric surgery High 41796654
2026 SARS-CoV-2 non-spike structural proteins (particularly the Envelope protein) induce epithelial cell dedifferentiation and apoptosis through CNN2 as a downstream effector; CNN2 levels were elevated in COVID-19 patient epithelia, downregulating CNN2 inhibited epithelial apoptosis and promoted differentiation, and CNN2 expression is negatively regulated by the transcription factor GLIS2. Viral protein overexpression in epithelial cells, CNN2 knockdown functional assays (apoptosis, differentiation), patient tissue immunostaining, GLIS2 regulatory analysis Cell death & disease Medium 41872170

Source papers

Stage 0 corpus · 57 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells. Gene 144 26970176
2010 CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. The Journal of cell biology 100 20368616
2021 Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease. Journal of neuroscience research 73 33729626
2006 Identification of dysregulated genes in cutaneous squamous cell carcinoma. Oncology reports 60 16865251
2008 Role of H2-calponin in regulating macrophage motility and phagocytosis. The Journal of biological chemistry 58 18617524
2005 A critical role for calponin 2 in vascular development. The Journal of biological chemistry 58 16317011
2011 Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization. Clinical and experimental medicine 50 21331762
2019 Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis. Human molecular genetics 34 30371777
2013 Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration. Cell reports 34 23499442
2022 Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1. Molecular cell 33 35793674
2018 Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants. Frontiers in neuroscience 31 30210277
2018 Comprehensive analysis of miRNA-mRNA-lncRNA networks in severe asthma. Epigenomics 31 30426778
2013 Androgen-responsive serum response factor target genes regulate prostate cancer cell migration. Carcinogenesis 31 23576568
2022 Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair. International journal of molecular sciences 29 36430812
2015 The potential role of DNA methylation in abdominal aortic aneurysms. International journal of molecular sciences 28 25993294
2016 Deletion of calponin 2 in macrophages alters cytoskeleton-based functions and attenuates the development of atherosclerosis. Journal of molecular and cellular cardiology 26 27575021
2019 LncRNA NEAT1 Promotes Proliferation, Migration And Invasion Via Regulating miR-296-5p/CNN2 Axis In Hepatocellular Carcinoma Cells. OncoTargets and therapy 21 31819486
2016 Deletion of calponin 2 in macrophages attenuates the severity of inflammatory arthritis in mice. American journal of physiology. Cell physiology 21 27488671
2024 Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p. Signal transduction and targeted therapy 20 39343927
2018 Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice. Journal of molecular and cellular cardiology 18 30053524
2021 Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma. NPJ genomic medicine 16 33574286
2023 Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis. Molecular metabolism 15 36963615
2017 Knockdown of calponin 2 suppressed cell growth in gastric cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 15 28714360
2016 Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force. Biochemistry 14 27733037
2023 Calponin 2 regulates ketogenesis to mitigate acute kidney injury. JCI insight 13 37751293
2018 Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo. International journal of medical sciences 13 29333089
2015 Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC genomics 13 25765115
2012 In vitro evaluation of the effectiveness of new water-stable cationic carbosilane dendrimers against Acanthamoeba castellanii UAH-T17c3 trophozoites. Parasitology research 13 23263327
2022 Identification of an 11 immune-related gene signature as the novel biomarker for acute myocardial infarction diagnosis. Genes and immunity 12 36182975
2023 The CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins. Proceedings of the National Academy of Sciences of the United States of America 8 37903270
2022 Deep Learning-Based Classification of Cancer Cell in Leptomeningeal Metastasis on Cytomorphologic Features of Cerebrospinal Fluid. Frontiers in oncology 8 35273914
2023 Immune response and mesenchymal transition of papillary thyroid carcinoma reflected in ultrasonography features assessed by radiologists and deep learning. Journal of advanced research 7 37783270
2019 Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice. International journal of molecular sciences 7 31151297
2024 AI-algorithm training and validation for identification of endometrial CD138+ cells in infertility-associated conditions; polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF). Journal of pathology informatics 6 38827567
2020 Ectopic expression of CNN2 of colon cancer promotes cell migration. Translational cancer research 6 35117451
2023 CNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1. Life science alliance 5 37188478
2022 circCNN2 Accelerates Cell Proliferation and Invasion in Lung Squamous Cell Carcinoma via Regulating miR-184/E2F1 and Activating MAPK Signaling Pathway. Disease markers 5 36016851
2021 Serum calponin 2 is a novel biomarker of tubal ectopic pregnancy. Fertility and sterility 5 34217487
2020 Normalization Method Utilizing Endogenous Proteins for Quantitative Proteomics. Journal of the American Society for Mass Spectrometry 5 32268065
2023 Exploration of the immunogenetic landscape of hyperprogressive disease after combined immunotherapy in cancer patients. iScience 4 37255657
2023 Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB. eLife 4 37982489
2023 The Role of H2-Calponin Antigen in Cancer Metastasis: Presence of Autoantibodies in Liver Cancer Patients. International journal of molecular sciences 3 37373013
2023 [12]aneN3-modified camptothecin and PEGylated AIEgens co-assembly into core-shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy. Journal of materials chemistry. B 3 37727888
2021 Exploration of Alternative Splicing Events in Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells. Genes 3 34068253
2024 Loss of Calponin 2 causes premature ovarian insufficiency in mice. Journal of ovarian research 2 38336796
2024 Deep learning-based optimization of field geometry for total marrow irradiation delivered with volumetric modulated arc therapy. Medical physics 2 38634859
2025 Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 postural orthostatic tachycardia syndrome (PC-POTS) patients. Autonomic neuroscience : basic & clinical 1 40022872
2024 Opening SCID newborn screening for novel exon genetic variants through whole-exome sequencing in China. International immunopharmacology 1 38908084
2026 A De Novo Variant in Calponin2 Causes Intestinal Pseudo-obstruction: Evidence from Patient and Mouse Model. Journal of pediatric surgery 0 41796654
2026 SARS-CoV-2 nonspike structural proteins hijack mucosa epithelial cell fate. Cell death & disease 0 41872170
2026 Functional Analysis of Late-Onset Alzheimer's Disease Risk Genes in Caenorhabditis elegans Identifies Regulators of Neuronal Aging. bioRxiv : the preprint server for biology 0 41959118
2026 Dynamic landscape of microRNA expression in the feline small intestine during Toxoplasma gondii infection. Parasites & vectors 0 41965856
2025 H2-calponin attenuate metastasis in human NSCLC by suppressing RSK2 expression. Pathology, research and practice 0 40700931
2025 Whole Exome Sequencing for the Identification of Mutations in Bone Marrow CD34+Cells in Hodgkin Lymphoma. Current issues in molecular biology 0 41296384
2025 Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles. Current biology : CB 0 41297546
2023 Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis. bioRxiv : the preprint server for biology 0 36711748
2015 [Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates]. Zhonghua yi xue za zhi 0 26711386