Affinage

CIAPIN1

Anamorsin · UniProt Q6FI81

Length
312 aa
Mass
33.6 kDa
Annotated
2026-06-09
43 papers in source corpus 28 papers cited in narrative 28 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIAPIN1 is a redox-responsive anti-apoptotic and pro-proliferative factor that integrates stress and growth signals to control cell survival, cell cycle progression, and migration across diverse cell types (PMID:18293492, PMID:23444317, PMID:34289085). Its most directly resolved mechanism is transcriptional repression of the Tp53 tumor suppressor: CIAPIN1 binds consensus sites in the Tp53 promoter and represses its transcription, and PDGF-BB-induced ROS drives its nuclear translocation through a C-terminal NLS (residues 236-239) via the importin-α/β pathway, so that NLS deletion or blockade of nuclear import restores p53 and limits neointimal formation in vivo (PMID:42094595). Consistent with a survival/proliferation role, CIAPIN1 enforces G1/S progression through cyclin D1, cyclin E, CDK2/CDK4, p27Kip1, and Rb (PMID:18293492, PMID:19081179), and confers multidrug resistance by upregulating MDR-1, Bcl-2/Bcl-xL and suppressing Bax, in a manner independent of glutathione status and of wild-type p53 (PMID:16410721, PMID:18059532, PMID:21240465). It acts upstream of NHE1-ERK1/2 signaling to govern leukemic differentiation and tumor cell migration (PMID:25043809, PMID:25724898) and upstream of JAK2/STAT3 to drive vascular smooth muscle phenotypic switching, with CIAPIN1 itself a transcriptional target of STAT3 in a feed-forward CIAPIN1/JAK2/STAT3 axis (PMID:34289085, PMID:40370537). CIAPIN1 also suppresses ferroptosis via PI3K/AKT-dependent induction of SLC7A11 and GPX4 (PMID:40259237) and preserves mitochondrial integrity through a CIAPIN1-OPA1 axis (PMID:41713137). Functional conservation is established by yeast complementation, and its twin-cysteine CX2C motif is essential for activity (PMID:23444317); recombinant CIAPIN1 lacks methyltransferase and AdoMet-binding activity despite a predicted motif (PMID:17935775).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2006 Medium

    Established that CIAPIN1 functions as a determinant of chemoresistance and apoptosis, defining its core cytoprotective role.

    Evidence Reciprocal cDNA overexpression and RNAi in gastric cancer cells with drug sensitivity assays and Western blotting

    PMID:16410721

    Open questions at the time
    • Mechanism of MDR-1/MRP-1 upregulation not defined
    • Direct molecular targets unidentified
  2. 2006 Medium

    Resolved where CIAPIN1 resides, showing dual cytoplasmic/nuclear localization with nucleolar accumulation and predicting regulated nuclear trafficking.

    Evidence IHC, immunofluorescence, and subcellular fractionation in human and mouse cells

    PMID:16957168

    Open questions at the time
    • NLS/NES predictions were bioinformatic only at this stage
    • Trigger for translocation unknown
  3. 2007 Medium

    Linked CIAPIN1 to multidrug resistance at the transcriptional level and tied it to cell cycle arrest, distinguishing its action from glutathione-based detoxification.

    Evidence Luciferase reporter and RT-PCR in leukemia cells, plus reciprocal gain/loss with cell cycle analysis in gastric cancer cells

    PMID:18059532 PMID:18293492

    Open questions at the time
    • Whether CIAPIN1 binds MDR-1/Bcl-2 promoters directly not tested
    • Connection between cell cycle and drug resistance roles unclear
  4. 2007 Medium

    Tested and excluded a predicted enzymatic identity, showing CIAPIN1 is not a methyltransferase and does not bind AdoMet.

    Evidence In vitro methyltransferase/demethylase and 3H-AdoMet binding assays with purified recombinant protein

    PMID:17935775

    Open questions at the time
    • Negative result does not assign an alternative biochemical activity
    • Native cofactor, if any, unknown
  5. 2008 Medium

    Generalized the proliferation/cell cycle role across tumor types, defining the cyclin/CDK/p27/Rb effectors that CIAPIN1 controls.

    Evidence Adenoviral RNAi/restoration in HCC and renal carcinoma with xenografts and Western blotting

    PMID:18299278 PMID:19081179

    Open questions at the time
    • Upstream regulator driving cyclin changes not identified
    • Direct versus indirect control of these proteins unresolved
  6. 2013 High

    Established functional conservation and identified the CX2C motif as essential, anchoring CIAPIN1 function to a defined structural element.

    Evidence Drosophila genetic alleles, yeast complementation, and CX2C mutation with proliferation/survival readouts

    PMID:23444317

    Open questions at the time
    • Biochemical function of the CX2C motif not defined
    • Whether the motif mediates metal/redox chemistry untested
  7. 2014 Medium

    Placed CIAPIN1 upstream of NHE1-ERK1/2 signaling controlling differentiation and migration, establishing an effector pathway via epistasis.

    Evidence shRNA knockdown with NHE1 rescue and ERK inhibitor in K562 cells; overexpression with NHE1/MEK inhibitors in breast cancer cells

    PMID:25043809 PMID:25724898

    Open questions at the time
    • How CIAPIN1 regulates NHE1 expression unknown
    • Direct physical link to the pathway not shown
  8. 2018 Medium

    Identified upstream miRNA regulation of CIAPIN1, embedding it in stress-survival circuits in cardiomyocytes.

    Evidence Dual-luciferase 3'UTR reporters and rescue knockdown for miR-182-5p and miR-16 with apoptosis assays

    PMID:29671338 PMID:31432171

    Open questions at the time
    • Physiological relevance of these miRNA-CIAPIN1 axes in vivo limited
    • Downstream apoptotic mechanism inferred from protein levels
  9. 2019 Medium

    Demonstrated that delivered CIAPIN1 protein is cytoprotective and anti-inflammatory under oxidative/inflammatory stress, implicating MAPK/NF-κB/Akt signaling.

    Evidence Tat-CIAPIN1 fusion protein transduction in neurons and macrophages with ischemia and TPA skin models

    PMID:30818058 PMID:31722779

    Open questions at the time
    • Whether endogenous CIAPIN1 acts through the same pathways untested
    • Direct molecular targets of CIAPIN1 in these pathways unknown
  10. 2021 Medium

    Connected CIAPIN1 to vascular remodeling by showing it represses Tp53 and activates JAK2/STAT3 to drive smooth muscle phenotypic switching.

    Evidence Lentiviral gain/loss-of-function with balloon injury/ligation neointima models and Western blotting

    PMID:34289085

    Open questions at the time
    • Mechanism of Tp53 repression not yet defined here
    • Whether JAK2/STAT3 activation is direct unresolved
  11. 2025 Medium

    Closed a regulatory loop by establishing CIAPIN1 as a transcriptional target of STAT3, defining a feed-forward CIAPIN1/JAK2/STAT3 axis in vascular cells.

    Evidence STAT3 SH2-domain compound binding with CIAPIN1 overexpression rescue in neointima models

    PMID:40370537

    Open questions at the time
    • Direct STAT3 binding to the CIAPIN1 promoter not shown
    • Quantitative contribution of the loop in vivo unclear
  12. 2025 Low

    Extended CIAPIN1 to ferroptosis control, showing PI3K/AKT-dependent induction of SLC7A11 and GPX4.

    Evidence Overexpression with PI3K inhibitor LY294002 and ferroptosis-marker measurement in podocytes

    PMID:40259237

    Open questions at the time
    • No genetic rescue of the PI3K/AKT dependency
    • Direct link between CIAPIN1 and PI3K activation unestablished
  13. 2026 High

    Provided the definitive mechanism for CIAPIN1's transcriptional action, demonstrating direct Tp53 promoter binding and ROS-triggered importin-dependent nuclear import.

    Evidence ChIP and luciferase reporters, NLS site-directed mutagenesis, NAC/ivermectin blockade, and carotid balloon injury model

    PMID:42094595

    Open questions at the time
    • Whether CIAPIN1 acts alone or with cofactors at the Tp53 promoter unknown
    • Structural basis of DNA binding not resolved
  14. 2026 Medium

    Defined a mitochondrial protective function via a CIAPIN1-OPA1 axis and identified WTAP-mediated m6A modification as an upstream regulator.

    Evidence Gain/loss-of-function with OPA1 rescue, membrane potential assays, m6A analysis, and a sepsis AKI model

    PMID:41713137

    Open questions at the time
    • Direct physical interaction of CIAPIN1 with OPA1 not demonstrated
    • Mechanism by which CIAPIN1 stabilizes OPA1 unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The intrinsic biochemical activity of CIAPIN1 and the function of its essential CX2C motif remain undefined, leaving open how a single protein executes transcriptional repression, redox sensing, and mitochondrial protection.
  • No assigned catalytic or cofactor-binding activity
  • No structural model of DNA binding or partner engagement
  • Mechanistic unity across its many reported pathways untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 3 GO:0003677 DNA binding 1
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0005730 nucleolus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-74160 Gene expression (Transcription) 1
Partners
OPA1TP53

Evidence

Reading pass · 28 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 CIAPIN1 overexpression in gastric cancer cells upregulates MDR-1 (P-glycoprotein) and MRP-1 expression, reduces intracellular adriamycin accumulation, and protects cells from ADR-induced apoptosis; knockdown sensitizes cells to anticancer drugs. CIAPIN1 also decreased expression of Bcl-2, Bax, and p53. cDNA transfection and RNA interference (stable transfectants), in vitro drug sensitivity assay, Western blotting, flow cytometry Cancer biology & therapy Medium 16410721
2006 CIAPIN1 protein localizes to both the cytoplasm and nucleus, with accumulation in the nucleolus, in human and mouse cells. Bioinformatic prediction identified a putative nuclear localization signal and nuclear export signal, suggesting cytoplasm-nucleus-nucleolus translocation. Immunohistochemistry, immunofluorescence, His-tagged CIAPIN1 expression, subcellular fractionation + Western blotting The journal of histochemistry and cytochemistry Medium 16957168
2007 CIAPIN1 upregulates MDR-1 and Bcl-2 transcription and downregulates Bax in leukemia cells, conferring multidrug resistance; this was independent of glutathione-S-transferase activity and intracellular glutathione content. Eukaryotic expression vector transfection, RNAi, semiquantitative RT-PCR, Western blot, luciferase reporter assay, flow cytometry Biochemistry and cell biology Medium 18059532
2007 CIAPIN1 induces G1/S cell cycle arrest in gastric cancer cells, with downregulation of CyclinD1 and upregulation of p27Kip1 as contributing molecular mechanisms; ectopic CIAPIN1 suppresses proliferation while knockdown accelerates it. Adenovirus-mediated cDNA expression and siRNA knockdown, cell cycle analysis by flow cytometry, Western blotting, soft agar colony assay, in vivo xenograft Cancer biology & therapy Medium 18293492
2007 Recombinant human CIAPIN1 expressed in baculovirus-insect cell system does NOT exhibit DNA methyltransferase, RNA methyltransferase, or DNA demethylase activity, and does not bind S-adenosyl-methionine in vitro, despite bioinformatic prediction of a methyltransferase motif. Baculovirus expression and Ni-NTA purification, in vitro DNA/RNA methyltransferase assay, demethylation assay, 3H-AdoMet binding test International journal of biological macromolecules Medium 17935775
2008 CIAPIN1 knockdown inhibits HCC cell proliferation by blocking S-phase entry and reduces anchorage-independent colony formation; adenovirus-delivered CIAPIN1 siRNA suppresses tumor growth in vivo. Adenovirus-mediated RNAi, cell proliferation assay, cell cycle analysis, soft agar colony formation, in vivo xenograft Carcinogenesis Medium 18299278
2008 Adenoviral restoration of CIAPIN1 in clear cell renal cell carcinoma cells causes G1 arrest and inhibits growth in vitro and in vivo, accompanied by decreased cyclinD1, cyclinE, CDK2, CDK4, p-Rb, and VEGF, and increased p27Kip1 and Rb. Adenoviral CIAPIN1 delivery, cell cycle analysis, Western blotting, in vivo xenograft Cancer letters Medium 19081179
2009 CIAPIN1 siRNA in SGC7901 gastric cancer cells suppresses in vitro proliferation, migration, and tube formation of co-cultured endothelial cells (conditioned medium), and inhibits in vivo tumorigenicity and angiogenesis. Stable siRNA transfection, HUVEC proliferation/migration/tube formation assay with conditioned medium, in vivo xenograft angiogenesis Cancer biology & therapy Low 19502810
2011 CIAPIN1 confers multidrug resistance in colon carcinoma cells by upregulating MDR-1 (P-gp) and Bcl-xL, and this function is independent of the wild-type p53 signaling pathway. siRNA knockdown and gene transfection, drug sensitivity assay, Western blotting, p53 inactivation analysis Oncology reports Medium 21240465
2013 Drosophila CIAPIN1 (D-CIAPIN1) is required for follicle cell proliferation and survival during ovarian development; mutation of the conserved twin-cysteine CX2C motif abolishes protein function; D-CIAPIN1 complements yeast CIAPIN1-deletion strain nonviability. Genetic allele analysis, yeast complementation, mitotic index quantification, cell death assay in Drosophila mutants Developmental dynamics High 23444317
2013 CIAPIN1 siRNA inhibits proliferation and migration of vascular smooth muscle cells (VSMCs) and promotes apoptosis, accompanied by downregulation of Bcl-2 and upregulation of Bax. Adenovirus-encoded CIAPIN1 siRNA transduction into VSMCs, proliferation/migration/apoptosis assays, Western blotting Current neurovascular research Low 23151078
2014 CIAPIN1 depletion in K562 CML cells induces granulocytic differentiation via decreased NHE1 (Na+/H+ exchanger 1) expression and upregulated ERK1/2 phosphorylation; NHE1 inhibition further promotes differentiation, while NHE1 overexpression reverses it; ERK1/2 inhibitor (PD98059) abolishes this differentiation. shRNA knockdown, ectopic NHE1 expression, chemical inhibitors (NHE1 inhibitor, PD98059), differentiation markers, Western blotting Leukemia research Medium 25043809
2015 CIAPIN1 knockdown in K562 CML cells decreases ERK5 phosphorylation and NF-κB activity; combined inhibition of ERK5 (XMD8-92) and NF-κB (Bay 11-7082) with CIAPIN1 depletion synergistically inhibits proliferation and promotes apoptosis, enhancing imatinib sensitivity. shRNA knockdown, chemical inhibitors (XMD8-92, Bay 11-7082), proliferation/apoptosis assays, Western blotting, nude mice transplantation model Biochemical pharmacology Medium 26679828
2015 CIAPIN1 overexpression in MDA-MB-231 breast cancer cells inhibits migration, invasion, and MMP expression by decreasing NHE1 expression and ERK1/2 phosphorylation; NHE1 inhibitor (Cariporide) and MEK1 inhibitor (PD98059) synergistically suppress these effects. Lentiviral overexpression, migration/invasion assays, MMP expression analysis, Western blotting, chemical inhibitors Experimental cell research Medium 25724898
2018 miR-182-5p directly binds the 3'UTR of CIAPIN1 mRNA (confirmed by dual-luciferase reporter assay) and negatively regulates CIAPIN1 expression; CIAPIN1 knockdown abolishes the protective effect of miR-182-5p inhibition on hypoxia-induced cardiomyocyte apoptosis. Dual-luciferase reporter assay, RT-qPCR, Western blotting, siRNA knockdown, annexin V/PI apoptosis assay, caspase-3 activity assay Biochemistry and cell biology Medium 29671338
2019 Tat-CIAPIN1 fusion protein transduces into HT-22 hippocampal neurons and brain tissue, inhibiting H2O2-induced cell death and ischemic neuronal death by regulating Akt, MAPK (ERK, JNK, p38), NF-κB, and apoptotic (Bcl-2/Bax/caspase) signaling pathways. Tat fusion protein transduction, cell viability assay, ROS measurement, DNA fragmentation, Western blotting, ischemia animal model Free radical biology & medicine Medium 30818058
2019 Tat-CIAPIN1 transduction into LPS-exposed macrophages reduces ROS, DNA fragmentation, MAPKs and NF-κB activation, and suppresses pro-inflammatory mediators (COX-2, iNOS, IL-6, TNF-α) and Bax/caspase-3; in a TPA-induced mouse skin inflammation model, transduced Tat-CIAPIN1 decreases inflammatory damage. Tat fusion protein cell transduction, ROS assay, DNA fragmentation, MAPK/NF-κB Western blotting, cytokine measurement, TPA mouse model BMB reports Medium 31722779
2019 miR-16 directly targets the 3'UTR of CIAPIN1 and negatively modulates CIAPIN1 expression; CIAPIN1 overexpression reverses hypoxia/reoxygenation-induced changes in apoptosis-associated proteins and modulates NF-κB/IκBα phosphorylation. Dual-luciferase reporter assay, RT-qPCR, Western blotting, miR-16 mimics/inhibitor, CIAPIN1 overexpression, flow cytometry Molecular medicine reports Medium 31432171
2021 CIAPIN1 negatively regulates Tp53 transcription, promoting VSMC cell cycle progression and migration via cyclin E1–CDK2/pRb/PCNA and MMP2 pathways; CIAPIN1 also increases JAK2 expression and enhances JAK2/STAT3 phosphorylation upon vascular injury, driving phenotypic switching from contractile to synthetic state. Lentiviral gain- and loss-of-function, balloon injury and ligation neointima models in rat/mouse carotid arteries, Western blotting, cell cycle/proliferation/migration assays British journal of pharmacology Medium 34289085
2021 Tat-CIAPIN1 protein transduction protects pancreatic RINm5F β-cells from cytokine-induced cytotoxicity by reducing ROS/DNA fragmentation, inhibiting MAPK and NF-κB activation, elevating Bcl-2, and reducing Bax and cleaved Caspase-3. Tat fusion protein transduction, cell viability assay, ROS assay, Western blotting (MAPK, NF-κB, Bcl-2/Bax/caspase-3) BMB reports Low 34120676
2022 CIAPIN1 silencing in cholangiocarcinoma KKU-100 cells suppresses migration and invasion; bioinformatic analysis of CIAPIN1-interacting proteins identified via LC-MS/MS after siRNA knockdown predicts connection to TGF-β/SMADs pathway via NOS1. siRNA knockdown, LC-MS/MS proteomics, transwell migration/invasion assay, bioinformatics pathway prediction Journal of clinical medicine Low 35807116
2023 Tat-CIAPIN1 protein protects pancreatic β-cells from hIAPP-induced toxicity by reducing MAPK activation and regulating COX-2, iNOS, Bcl-2, Bax, and Caspase-3; in an HFD/STZ T2DM mouse model, Tat-CIAPIN1 ameliorated pathological changes in pancreatic β-cells and reduced fasting blood glucose. Tat fusion protein transduction, cell viability, Western blotting, T2DM mouse model (HFD+STZ), blood glucose measurement International journal of molecular sciences Low 37445656
2024 CIAPIN1 downregulation in breast cancer cells suppresses proliferation, migration, and glycolysis (pyruvate, lactate, ATP production) and reduces PKM2 expression and STAT3 phosphorylation, placing CIAPIN1 upstream of the STAT3/PKM2 pathway. siRNA knockdown, RT-qPCR, Western blotting, proliferation/migration assays, metabolite measurement Scientific reports Low 39242716
2025 CIAPIN1 overexpression in LPS-induced podocytes activates the PI3K/AKT pathway (elevated p-PI3K and p-Akt), increases ferroptosis-protective proteins SLC7A11 and GPX4, and attenuates ferroptosis markers (MDA, Fe2+); PI3K inhibitor LY294002 reverses these effects, confirming pathway dependency. CIAPIN1 overexpression vector, PI3K inhibitor (LY294002), Western blotting, MDA/Fe2+ measurement, RT-qPCR BMC nephrology Low 40259237
2025 CIAPIN1 promotes proliferation and migration of PDGF-BB-activated airway smooth muscle cells; knockdown inhibits p-PI3K, p-Akt, p-JAK2, and p-STAT3, placing CIAPIN1 upstream of both PI3K/AKT and JAK2/STAT3 signaling in this context. siRNA knockdown, Western blotting, proliferation/migration/apoptosis assays Physiological reports Low 40338178
2025 A STAT3 inhibitor (CAB) suppresses VSMC CIAPIN1 transcription via STAT3/SH2 domain binding; CIAPIN1 overexpression reverses CAB-mediated suppression of VSMC proliferation, migration, and intimal hyperplasia, establishing CIAPIN1 as a transcriptional target of STAT3 in the CIAPIN1/JAK2/STAT3 axis. Compound binding to STAT3 SH2 domain, CIAPIN1 overexpression rescue, neointima animal models, Western blotting Acta pharmaceutica Sinica. B Medium 40370537
2026 CIAPIN1 directly binds consensus sites in the Tp53 promoter (confirmed by ChIP and dual-luciferase reporter assay) and represses Tp53 transcription in VSMCs. PDGF-BB-induced ROS production promotes nuclear translocation of CIAPIN1 via a C-terminal NLS (residues 236–239) through the importin-α/β pathway; deletion of the NLS (Δ236–239) or blocking nuclear import with NAC or ivermectin restores p53 expression and reduces neointimal formation in vivo. ChIP assay, dual-luciferase reporter assay, site-directed mutagenesis of NLS, ROS scavenger (NAC), importin inhibitor (ivermectin), subcellular fractionation, rat carotid balloon injury model Theranostics High 42094595
2026 CIAPIN1 interacts functionally with OPA1 (optic atrophy 1): CIAPIN1 overexpression maintains mitochondrial membrane potential and restores mitochondrial function-related proteins in LPS-stimulated renal tubular cells, while OPA1 overexpression rescues the detrimental effects of CIAPIN1 knockdown on apoptosis and mitochondrial dysfunction, defining a CIAPIN1–OPA1 signaling axis. WTAP promotes m6A modification of CIAPIN1 mRNA, reducing its expression under LPS. Gain- and loss-of-function (overexpression and siRNA), mitochondrial membrane potential assay, Western blotting, cecal ligation and puncture AKI mouse model, m6A modification analysis Pathology, research and practice Medium 41713137

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells. Cancer biology & therapy 50 16410721
2008 Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo. Carcinogenesis 45 18299278
2010 CIAPIN1 as a therapeutic target in cancer. Expert opinion on therapeutic targets 38 20367238
2008 CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. Cancer letters 38 19081179
2018 Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1. Biochemistry and cell biology = Biochimie et biologie cellulaire 33 29671338
2007 A new apoptosis inhibitor, CIAPIN1 (cytokine-induced apoptosis inhibitor 1), mediates multidrug resistance in leukemia cells by regulating MDR-1, Bcl-2, and Bax. Biochemistry and cell biology = Biochimie et biologie cellulaire 32 18059532
2007 CIAPIN1 inhibits gastric cancer cell proliferation and cell cycle progression by downregulating CyclinD1 and upregulating P27. Cancer biology & therapy 30 18293492
2006 Subcellular localization of CIAPIN1. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 30 16957168
2005 Distribution of CIAPIN1 in normal fetal and adult human tissues. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 30 16314443
2019 Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways. Free radical biology & medicine 24 30818058
2021 Cytokine-induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells. British journal of pharmacology 23 34289085
2015 Knock-down of CIAPIN1 sensitizes K562 chronic myeloid leukemia cells to Imatinib by regulation of cell cycle and apoptosis-associated members via NF-κB and ERK5 signaling pathway. Biochemical pharmacology 23 26679828
2005 Preparation and characterization of a specific monoclonal antibody against CIAPIN1. Hybridoma (2005) 20 15943561
2012 Down regulation of CIAPIN1 reverses multidrug resistance in human breast cancer cells by inhibiting MDR1. Molecules (Basel, Switzerland) 19 22717413
2009 Inhibiting gastric cancer-associated angiogenesis by CIAPIN1 siRNA. Cancer biology & therapy 19 19502810
2013 CIAPIN1 siRNA inhibits proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Current neurovascular research 18 23151078
2017 The study on expression of CIAPIN1 interfering hepatocellular carcinoma cell proliferation and its mechanisms. European review for medical and pharmacological sciences 15 28742201
2011 CIAPIN1 confers multidrug resistance through up-regulation of MDR-1 and Bcl-L in LoVo/Adr cells and is independent of p53. Oncology reports 15 21240465
2009 Downregulated expression of CIAPIN1 may contribute to gastric carcinogenesis by accelerating cell proliferation and promoting cell cycle progression. Cancer biology & therapy 15 19471113
2015 CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway. Experimental cell research 11 25724898
2007 Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity. International journal of biological macromolecules 10 17935775
2023 Tat-CIAPIN1 Prevents Pancreatic β-Cell Death in hIAPP-Induced RINm5F Cells and T2DM Animal Model. International journal of molecular sciences 9 37445656
2019 Downregulation of miR‑16 protects H9c2(2‑1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF‑κB pathway. Molecular medicine reports 9 31432171
2019 Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages. BMB reports 9 31722779
2008 [Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA]. Molekuliarnaia biologiia 9 18389626
2021 Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5F β-cells. BMB reports 6 34120676
2014 CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 6 24676475
2025 CIAPIN1 attenuates ferroptosis via regulating PI3K/AKT pathway in LPS-induced podocytes. BMC nephrology 5 40259237
2008 [CIAPIN1 expression in human lung cancer tissues and inhibitory effects of the gene on human pulmonary carcinoma NCI-H446 cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 5 18466694
2022 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis. Journal of clinical medicine 4 35807116
2021 Inhibition of miR-322-5p Protects Cardiac Myoblast Cells Against Hypoxia-Induced Apoptosis and Injury Through Regulating CIAPIN1. Journal of cardiovascular pharmacology 4 33538533
2025 CIAPIN1 promotes proliferation and migration of PDGF-BB-activated airway smooth muscle cells via the PI3K/AKT and JAK2/STAT3 signaling pathways. Physiological reports 2 40338178
2025 Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells. Acta pharmaceutica Sinica. B 2 40370537
2024 Serum CIAPIN1 is lower in septic patients with cardiac dysfunction. Peptides 2 39241831
2024 Downregulation of CIAPIN1 regulates the proliferation, migration and glycolysis of breast cancer cells via inhibition of STAT3 pathway. Scientific reports 2 39242716
2014 CIAPIN1 targets Na+/H+ exchanger 1 to mediate K562 chronic myeloid leukemia cells' differentiation via ERK1/2 signaling pathway. Leukemia research 2 25043809
2013 Drosophila CIAPIN1 homologue is required for follicle cell proliferation and survival. Developmental dynamics : an official publication of the American Association of Anatomists 2 23444317
2026 CIAPIN1 improves sepsis-induced acute kidney injury by inhibiting mitochondrial damage. Pathology, research and practice 0 41713137
2026 CIAPIN1 functions as a redox-sensitive transcriptional repressor of Tp53 during vascular remodeling. Theranostics 0 42094595
2025 CIAPIN1 promotes survival, proliferation, migration and glycolysis of endometrial cancer cells through PI3K/Akt pathway. Scientific reports 0 40730854
2025 CIAPIN1 as a Promoter of Oral Squamous Cell Carcinoma Progression. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 0 41189039
2014 [Effect of CIAPIN1 gene on proliferation of K562 cells]. Zhongguo shi yan xue ye xue za zhi 0 24989274
2011 [Expression of CIAPIN1 gene in BMMNC of patients with leukemia]. Zhongguo shi yan xue ye xue za zhi 0 21729524

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