Affinage

CDH11

Cadherin-11 · UniProt P55287

Length
796 aa
Mass
88.0 kDa
Annotated
2026-06-09
46 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CDH11 (Cadherin-11/OB-cadherin) is a Ca2+-dependent cell adhesion molecule whose extracellular EC domains mediate trans-adhesion and whose dysregulation acts as a context-dependent driver of differentiation, fibrosis, and tumor behavior (PMID:33811546, PMID:28988429). Loss-of-function truncating mutations cause Elsahy-Waters syndrome, with patient fibroblasts showing absent CDH11 protein, reduced proliferation, and delayed osteogenic differentiation (PMID:28988429), while heterozygous missense variants clustered at EC2-EC3/EC3-EC4 linkers impair Ca2+-dependent trans adhesion and perturb focal adhesion and migration, consistent with dominant-negative effects in facial mesenchyme (PMID:33811546). In fibrosis, CDH11 is a central mediator of myofibroblast and hepatic stellate cell activation: FOXF1 directly binds the Cdh11 promoter and a FOXF1-controlled switch from CDH2 to CDH11 drives pro-fibrotic myofibroblast invasion and collagen secretion, and CDH11 transduces TGF-β-induced stellate cell activation in liver injury (PMID:29642003, PMID:30509494). In cancer, CDH11 plays opposing roles depending on context — it acts as a pro-apoptotic tumor suppressor upstream of β-catenin in retinoblastoma and restrains transcellular invasion in tongue carcinoma (PMID:20421947, PMID:34295163), yet promotes EMT, invasion, and metastasis through TGF-β/Snail2, NF-κB, Wnt/β-catenin, RhoA/FAK, and JAK-STAT3/AKT signaling in cervical, gastric, and esophageal cancers (PMID:26706910, PMID:30987656, PMID:42127732, PMID:40460640, PMID:31160603). CDH11 also reprograms metabolism, inhibiting branched-chain ketoacid dehydrogenase to activate mTOR and modulating mitochondrial activity to support tumor growth (PMID:39739317, PMID:41263259), and is delivered via extracellular vesicles together with ITGA5 to educate osteoblasts and establish a bone premetastatic niche (PMID:35149589, PMID:38871245). CDH11 expression is controlled transcriptionally by FOXF1, Snail2, and SP1/GR (PMID:29642003, PMID:42127732, PMID:40362031), at the mRNA level by multiple microRNAs targeting its 3'UTR (miR-27b, miR-127-3p, miR-101-3p, miR-205a) (PMID:26706910, PMID:33574696, PMID:36809926, PMID:42091868), translationally by the m6A reader YTHDF1 (PMID:38871245), and at the protein level by USP14-mediated deubiquitination that prevents proteasomal degradation (PMID:41653235). Cdh11-null mice additionally display autism-like behaviors, indicating a role in neural circuits (PMID:34523068).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2004 Medium

    Established that the CDH11 promoter can be hijacked oncogenically, driving high-level transcription of the USP6 oncogene through a fusion-generating translocation.

    Evidence FISH/cytogenetics and rearrangement analysis on primary aneurysmal bone cysts

    PMID:15509545

    Open questions at the time
    • Does not address normal CDH11 protein function
    • Cell-type specificity of the translocation not mechanistically explained
  2. 2010 High

    Demonstrated that CDH11 acts as a pro-apoptotic tumor suppressor in vivo, promoting tumor cell death upstream of β-catenin rather than affecting proliferation.

    Evidence Cdh11 knockout mouse crossed with retinoblastoma model plus in vitro siRNA knockdown with caspase-3 and β-catenin readouts

    PMID:20421947

    Open questions at the time
    • Molecular link between CDH11 adhesion and caspase-3 activation unresolved
    • How CDH11 suppresses β-catenin not defined
  3. 2017 Medium

    Linked CDH11 loss-of-function directly to a Mendelian disease, showing absent protein and impaired osteogenic differentiation underlie Elsahy-Waters syndrome.

    Evidence Exome sequencing with patient-derived fibroblast protein, proliferation, and osteogenic differentiation assays

    PMID:28988429

    Open questions at the time
    • Tissue-level mechanism of malformation phenotypes not dissected
    • Single study
  4. 2018 High

    Identified FOXF1 as a direct transcriptional regulator of CDH11 and revealed a CDH2-to-CDH11 cadherin switch as a driver of fibrotic myofibroblast invasion.

    Evidence Fibroblast-specific FOXF1 knockout mice, ChIP on Cdh2/Cdh11 promoters, in vitro invasion rescue assays

    PMID:29642003

    Open questions at the time
    • How the cadherin switch mechanically promotes invasion unresolved
    • Downstream effectors of CDH11 in myofibroblasts not defined
  5. 2018 Medium

    Extended CDH11's pro-fibrotic role to liver, showing it transduces TGF-β-induced hepatic stellate cell activation in vivo.

    Evidence CDH11-deficient mice with CCl4-induced fibrosis and in vitro HSC activation/TGF-β assays

    PMID:30509494

    Open questions at the time
    • Position of CDH11 relative to canonical TGF-β signaling not mapped
    • Direct partners in stellate cells unknown
  6. 2015 Medium

    Established post-transcriptional control of CDH11 by miR-27b and placed CDH11 as an EMT regulator in cervical cancer.

    Evidence miR-27b modulation, CDH11 cDNA rescue, siRNA knockdown with EMT marker immunoblotting and invasion assays

    PMID:26706910

    Open questions at the time
    • Direct 3'UTR binding not validated by reporter in this study
    • Pro-EMT role conflicts with tumor-suppressor reports, context not reconciled
  7. 2019 Medium

    Placed CDH11 within drug-resistance and metastatic signaling networks, downstream of EPHA2/JNK driving RhoA/FAK-mediated adhesion-dependent resistance and within an NF-κB positive feedback loop sustaining metastasis.

    Evidence EPHB6 mutant cell models, kinase/pathway inhibitors, CDH11 knockdown, NF-κB inhibition and promoter binding assays

    PMID:30987656 PMID:31160603 PMID:31248373

    Open questions at the time
    • Whether CDH11 acts through adhesion or independent signaling unclear
    • Receptors transducing CDH11 in these contexts not all defined
  8. 2021 Medium

    Resolved structural determinants of CDH11 adhesion, showing EC linker missense variants impair Ca2+-dependent trans adhesion and behave dominant-negatively in facial mesenchyme.

    Evidence Cell-substrate trans adhesion, morphology/focal adhesion imaging, migration assays, IHC, exome sequencing across families

    PMID:33811546

    Open questions at the time
    • No high-resolution structure of the dimerization interface
    • Link between adhesion defect and craniofacial phenotype incomplete
  9. 2021 Medium

    Identified miRNA-CDH11-Wnt/β-catenin axes governing chondrocyte and valve cell differentiation/calcification, with CDH11 driving Wnt activation.

    Evidence Exosomal miR-127-3p transfer and miR-101-3p modulation in primary chondrocytes and aortic valve interstitial cells with CDH11 rescue and pathway readouts

    PMID:33574696 PMID:36809926

    Open questions at the time
    • Direct CDH11-to-Wnt mechanistic connection not biochemically defined
    • Context-dependent directionality of CDH11 in differentiation unexplained
  10. 2021 Medium

    Demonstrated a context where CDH11 functions as an invasion suppressor by enhancing tumor-epithelial adhesion and blocking transcellular migration, and linked CDH11 to autism-relevant neural circuits.

    Evidence CDH11 overexpression with adhesion/transcellular migration assays in oral carcinoma; Cdh11 knockout behavioral battery with Cdh9 control

    PMID:34295163 PMID:34523068

    Open questions at the time
    • Neural substrate of behavioral phenotype not identified
    • Molecular basis of adhesion-driven invasion suppression undefined
  11. 2022 Medium

    Revealed an extracellular-vesicle role for CDH11 protein in establishing an osteogenic premetastatic niche, acting with ITGA5 to enable bone colonization.

    Evidence EV transfer assays, CDH11/ITGA5 proteomics, osteoblast education, breast cancer bone metastasis mouse models

    PMID:35149589

    Open questions at the time
    • Receptor on osteoblasts recognizing EV-CDH11 not identified
    • Mechanism of CDH11-ITGA5 cooperation unresolved
  12. 2024 Medium

    Uncovered metabolic functions of CDH11, linking it to BCAA metabolism/mTOR activation and identifying druggable nodes that engage ROS and cGAS-STING.

    Evidence Single-cell/spatial transcriptomics, CDH11 inhibitor treatment, BCAA/ROS/cGAS-STING readouts, lung metastasis models; YTHDF1 m6A regulation by RIP-seq/MeRIP-seq

    PMID:38871245 PMID:39739317

    Open questions at the time
    • How a cadherin mechanistically inhibits branched-chain ketoacid dehydrogenase unclear
    • Whether metabolic effects require adhesion function not tested
  13. 2025 Medium

    Consolidated CDH11 as a pro-tumor signaling hub in squamous and bladder cancers (JAK-STAT3/AKT, mitochondrial activity) and as a druggable target bound directly by celecoxib/DMC.

    Evidence CDH11 knockdown/overexpression, signaling and metabolic flux readouts, direct compound-CDH11 binding assays, xenograft models

    PMID:40460640 PMID:41263259

    Open questions at the time
    • Direct effectors coupling CDH11 to STAT3/AKT not identified
    • Reconciliation of pro- vs anti-tumor roles across tissues unresolved
  14. 2025 Medium

    Defined CDH11 receptor and feedforward mechanisms in inflammation and fibrosis, signaling through FGFR1 to recruit neutrophils and through a Piezo1/IL-6 loop in fibroblast activation.

    Evidence Recombinant CDH11 instillation with FGFR1 inhibition in asthma models; CDH11 knockout fibroblasts with Piezo1/IL-6 modulation (preprint)

    PMID:41329017 PMID:bio_10.1101_2025.09.16.674909

    Open questions at the time
    • Whether CDH11 directly binds FGFR1 not shown
    • Piezo1/IL-6 axis preprint awaits peer review
  15. 2025 Medium

    Identified protein-level (USP14 deubiquitination) and additional transcriptional (SP1/GR) and miRNA (miR-205a) regulators completing the multilayer control of CDH11 abundance.

    Evidence USP14 knockdown with ubiquitination assays and CDH11 rescue; SP1/GR promoter luciferase mapping in bovine muscle; miR-205a 3'UTR luciferase with Wnt/β-catenin rescue

    PMID:40362031 PMID:41653235 PMID:42091868

    Open questions at the time
    • SP1/GR regulation validated only in bovine model, not human
    • Coordination among the multiple regulatory layers not integrated
  16. 2026 Medium

    Established a CDH11-TGF-β1-Snail2 positive feedback loop driving EMT and gastric cancer metastasis.

    Evidence CDH11 gain/loss-of-function, TGF-β signaling readouts, Snail2 promoter binding, invasion and lung metastasis models

    PMID:42127732

    Open questions at the time
    • How CDH11 upregulates TGF-β1 mechanistically unknown
    • Generality of the loop beyond gastric cancer untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single adhesion molecule produces opposing tumor-suppressor versus pro-metastatic outcomes and how its adhesion function is mechanistically coupled to the diverse intracellular pathways (mTOR, FGFR1, JAK-STAT3, NF-κB) attributed to it.
  • No structural model of CDH11 signaling complexes
  • Direct receptor partners for CDH11 ligand activity unconfirmed
  • Determinants of tissue-specific tumor-suppressor vs pro-tumor function unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 3 GO:0048018 receptor ligand activity 2
Localization
GO:0005886 plasma membrane 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-1643685 Disease 2
Partners
FGFR1ITGA5

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 CDH11 promoter drives high-level transcriptional activation of USP6 oncogene in primary aneurysmal bone cysts via chromosomal translocation, creating a CDH11-USP6 fusion gene; rearrangements were restricted to spindle cells and absent in multinucleated giant cells, inflammatory cells, endothelial cells, and osteoblasts. FISH/cytogenetics, molecular rearrangement analysis on primary tumor tissue The American journal of pathology Medium 15509545
2010 Cdh11 loss-of-function in murine retinoblastoma promotes tumor cell survival by reducing cell death (5- to 10-fold decrease in apoptotic markers including activated caspase-3) without affecting proliferation; Cdh11 knockdown in vitro increases β-catenin expression, placing Cdh11 as a pro-apoptotic tumor suppressor upstream of β-catenin. Cdh11 knockout mouse crossed with TAg-RB tumor model; in vitro siRNA knockdown with caspase-3 and β-catenin immunostaining; in vivo tumor volume and cell death quantification PLoS genetics High 20421947
2015 miR-27b directly targets the CDH11 3'UTR to suppress CDH11 expression, and CDH11 mediates epithelial-mesenchymal transition (EMT) by regulating E-cadherin, vimentin, and N-cadherin expression in cervical cancer cells. miR-27b overexpression/inhibition, CDH11 cDNA rescue transfection, siRNA knockdown, proliferation and invasion assays, EMT marker immunoblotting Oncology reports Medium 26706910
2018 FOXF1 transcription factor directly binds Cdh2 and Cdh11 promoters to differentially regulate their transcription; FOXF1 deletion promotes a switch from N-cadherin (CDH2) to Cadherin-11 (CDH11) in lung myofibroblasts, which is a critical step driving pro-fibrotic myofibroblast invasion and collagen secretion. Re-expression of CDH2 or inhibition of CDH11 in FOXF1-deficient cells reduces myofibroblast invasion. Fibroblast-specific FOXF1 knockout mice, chromatin immunoprecipitation (ChIP) on Cdh2/Cdh11 promoters, in vitro invasion assays with CDH11 inhibition and CDH2 re-expression rescue Cell reports High 29642003
2018 CDH11 promotes liver fibrosis by activating hepatic stellate cells (HSCs); CDH11 mediates TGFβ-induced HSC activation, and CDH11-deficient mouse HSCs show decreased activation in vitro and reduced fibrogenesis in vivo following CCl4-induced chronic liver injury. CDH11-deficient mouse model, CCl4-induced fibrosis in vivo, in vitro HSC activation assays, TGFβ stimulation experiments Biochemical and biophysical research communications Medium 30509494
2019 EPHB6 mutation induces paclitaxel resistance via interaction with EPHA2, which promotes JNK-mediated CDH11 expression; elevated CDH11 then mediates cell adhesion-mediated drug resistance (CAM-DR) through RhoA/FAK activation. Targeted inhibition of CDH11 reversed acquired paclitaxel resistance. EPHB6 mutation cell line models, kinase inhibitor experiments, CDH11 siRNA knockdown, RhoA/FAK signaling readouts, drug resistance assays Experimental & molecular medicine Medium 31160603
2019 In metastatic breast cancer cells co-cultured with CDH11-rich cancer-associated fibroblasts, anti-CDH11 antibody suppresses CDH11, β-catenin, fibronectin, and vimentin expression, abrogating cancer stem cell-like traits and metastasis; ectopic miR-335 expression suppresses CDH11 and downstream β-catenin/vimentin, while CDH11 inhibition upregulates miR-335. Anti-CDH11 monoclonal antibody treatment, miR-335 mimic/inhibitor transfection, co-culture with CAFs, in vivo xenograft tumor models, protein expression analysis BMC cancer Medium 31248373
2019 C12orf59 upregulates CDH11 expression via NF-κB signaling; in turn, CDH11 promotes NF-κB binding to the C12orf59 promoter, forming a positive feedback loop that sustains gastric cancer cell metastatic ability. Gain- and loss-of-function studies in vitro and in vivo, NF-κB pathway inhibition, promoter binding assays, invasion/metastasis assays Journal of experimental & clinical cancer research : CR Medium 30987656
2021 Pathogenic CDH11 heterozygous missense variants clustered around EC2-EC3 and EC3-EC4 linker regions (predicted to affect Ca2+ binding required for cadherin stability) significantly reduced cell-substrate trans adhesion activity; one EC3-EC4 linker variant caused changes in cell morphology, focal adhesion, and migration, suggesting a dominant negative effect. CDH11 protein is strongly expressed in human facial mesenchyme. Cell-substrate trans adhesion functional assays, cell morphology and focal adhesion imaging, migration assays, immunohistochemistry of human facial mesenchyme, exome sequencing validation Human genetics Medium 33811546
2021 Exosomal miR-127-3p from bone marrow-derived mesenchymal stem cells inhibits CDH11 in chondrocytes, blocking Wnt/β-catenin pathway activation; overexpression of CDH11 reverses the protective exosome effects by reactivating Wnt/β-catenin signaling in IL-1β-injured chondrocytes. Exosome isolation and transfer, miR-127-3p inhibition, CDH11 overexpression rescue, Wnt/β-catenin pathway readouts, IL-1β chondrocyte injury model Journal of pain research Medium 33574696
2021 CDH11 overexpression in tongue squamous cell carcinoma cells increases adhesion to human oral epithelial cells and decreases their ability to undergo transcellular migration through epithelial cells, acting as a tumor suppressor for invasion without affecting proliferation, apoptosis, stemness, or direct migration. CDH11 overexpression, adhesion assays with oral epithelial cells, transcellular migration assays, proliferation and apoptosis assays OncoTargets and therapy Medium 34295163
2021 Cdh11-null mice (but not Cdh9-null mice) display multiple autism-like behavioral alterations, supporting a functional role for CDH11 in the neural circuits underlying autism spectrum disorder behaviors. Cdh11 knockout mouse behavioral studies (autism-relevant behavioral battery), comparison with Cdh9 knockout mice Neuroscience bulletin Medium 34523068
2022 Extracellular vesicles (EVs) from RUNX2-high breast cancer cells deliver CDH11 protein to osteoblasts, mediating specific EV recognition and inducing an osteogenic premetastatic niche; CDH11 in EVs works together with ITGA5 to facilitate subsequent bone colonization of breast cancer cells. In vitro and in vivo EV transfer assays, CDH11/ITGA5 protein identification in EVs by proteomics, osteoblast education experiments, breast cancer bone metastasis mouse models Cancer research Medium 35149589
2023 miR-101-3p directly targets CDH11 (and SOX9); inhibition of miR-101-3p restores CDH11 and SOX9 expression and prevents osteogenic differentiation/calcification of human aortic valve interstitial cells under calcific conditions. miR-101-3p mimic/inhibitor in primary HAVICs, CDH11/SOX9 expression readouts, calcification assays under osteogenic conditioned medium Molecular medicine (Cambridge, Mass.) Medium 36809926
2023 FOXF1 overexpression inhibits TGF-β1-induced bronchial epithelial cell injury, fibrosis, and EMT by suppressing CDH11 expression and CDH11-mediated Wnt/β-catenin pathway activation; CDH11 overexpression reverses these protective FOXF1 effects. FOXF1 and CDH11 overexpression in TGF-β1-treated BEAS-2B cells, Wnt/β-catenin pathway protein readouts, fibrosis/EMT marker analysis, proliferation and apoptosis assays Experimental and therapeutic medicine Medium 36798677
2024 YTHDF1 (an m6A reader) promotes CDH11 translation by reading m6A-enriched sites on CDH11 transcripts, as demonstrated by RIP-seq and MeRIP-seq; increased CDH11 expression downstream of YTHDF1 promotes breast cancer osteoblast adhesion and facilitates bone metastasis. RNA-seq, MeRIP-seq, RIP-seq, molecular biology (YTHDF1 knockdown/overexpression), AAV-mediated shYTHDF1 delivery in intratibial injection models Cancer letters Medium 38871245
2024 CDH11 inhibits branched-chain ketoacid dehydrogenase to activate the mTOR pathway by interfering with branched-chain amino acid (BCAA) metabolism; CDH11 inhibitors (celecoxib and derivatives) regulate BCAA metabolism, increase ROS production, and activate the cGAS-STING pathway, suppressing lung metastasis in vivo. Single-cell RNA sequencing, spatial transcriptomics, CDH11 inhibitor treatment, BCAA metabolism assays, ROS measurement, cGAS-STING pathway readouts, NOD-SCID mouse lung metastasis models Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 39739317
2025 CDH11 knockdown in advanced bladder cancer cell lines suppresses mitochondrial metabolic activity (confirmed by Flux analyzer) and inhibits tumor growth in vivo, without affecting proliferation, invasion, or migration in vitro; a CDH11 inhibitor similarly decreases mitochondrial activity in vitro and suppresses tumor growth in vivo. shRNA-mediated CDH11 knockdown, RNA-seq, metabolic flux analysis, subcutaneous xenograft mouse model, CDH11 inhibitor treatment Cancer medicine Medium 41263259
2025 CDH11 promotes airway neutrophilic inflammation in severe asthma via FGFR1 signaling; intratracheal instillation of recombinant CDH11 recruits neutrophils to the lungs, and this recruitment is blocked by FGFR1 inhibition. Pharmacological CDH11 antagonism (SD133) reduces airway neutrophil accumulation and IL-6/TNF-α production without affecting eosinophilic or type 2 inflammation. Murine severe asthma models (TDI and OVA/CFA), CDH11 antagonist SD133, recombinant CDH11 intratracheal instillation, FGFR1 inhibitor experiments, bronchoalveolar lavage cytology, cytokine measurement FASEB journal Medium 41329017
2025 CDH11 knockdown in esophageal squamous cell carcinoma suppresses proliferation and invasion, while overexpression enhances them; CDH11 knockdown attenuates JAK-STAT3 and AKT signaling. Celecoxib and DMC directly bind CDH11 and inhibit ESCC growth in vitro and in vivo. CDH11 siRNA knockdown and overexpression, JAK-STAT3/AKT signaling readouts, direct drug-CDH11 binding assay, xenograft mouse model Pathology, research and practice Medium 40460640
2025 USP14 deubiquitinase stabilizes CDH11 protein through deubiquitination; USP14 knockdown decreases CDH11 protein levels, and CDH11 overexpression rescues USP14 knockdown effects in IL-1β-stimulated chondrocytes, identifying USP14 as the deubiquitinating writer that prevents CDH11 proteasomal degradation. USP14 knockdown, CDH11 overexpression rescue, ubiquitination/deubiquitination assays, cell viability/apoptosis/ferroptosis readouts in IL-1β chondrocyte model Clinical rheumatology Medium 41653235
2026 CDH11 promotes EMT and gastric cancer progression by upregulating TGF-β1 and activating TGF-β signaling; activated TGF-β signaling in turn enhances CDH11 transcription via binding of downstream transcription factor Snail2 to the CDH11 promoter, forming a positive feedback loop regulating invasion and metastasis. CDH11 gain/loss-of-function in GC cells, TGF-β1 expression and signaling readouts, Snail2 promoter binding assays, in vitro migration/invasion assays, lung metastasis in vivo model Translational oncology Medium 42127732
2026 miR-205a directly binds the 3'UTR of CDH11 mRNA (confirmed by dual-luciferase assay) and inhibits chondrocyte differentiation by suppressing CDH11; CDH11 functions as a positive regulator of chondrocyte differentiation by promoting Wnt/β-catenin signaling. Silencing miR-205a or overexpressing CDH11 promotes chondrogenesis via Wnt/β-catenin and upregulates Runx2 and BMP2. Dual-luciferase reporter assay for miR-205a/CDH11 3'UTR binding, miR-205a overexpression/silencing, CDH11 overexpression, Wnt/β-catenin pathway agonist rescue, chondrogenic differentiation markers (Runx2, BMP2) in avian embryonic models Cell death discovery Medium 42091868
2025 CDH11 knockout in lung fibroblasts suppresses fibroblast activation metrics (spreading and type I collagen expression), reduces Piezo1 expression, and decreases IL-6 secretion; blocking IL-6 signaling decreases CDH11 but not Piezo1 expression, establishing CDH11 as downstream of IL-6 and upstream of Piezo1/IL-6 in a feedforward fibroblast activation loop. CDH11 knockout fibroblasts in HA hydrogel platform, Piezo1 inhibition experiments, IL-6 signaling blockade, fibroblast-M2 macrophage co-culture, type I collagen expression and cell spreading readouts bioRxivpreprint Medium bio_10.1101_2025.09.16.674909
2017 Loss-of-function mutations in CDH11 (homozygous truncating/indel variants) cause Elsahy-Waters syndrome; patient fibroblasts show absent CDH11 protein expression, decreased cell proliferation rate, and delayed osteogenic differentiation potential compared to heterozygous parent and healthy donors. Exome sequencing and Sanger validation, immunostaining for CDH11 in patient-derived fibroblasts, cell proliferation assays, osteogenic differentiation assays American journal of medical genetics. Part A Medium 28988429
2025 Transcription factors SP1 and GR bind to the CDH11 gene promoter core region (at -36/-27 bp and -20/-11 bp relative to TSS, respectively) to regulate CDH11 expression in bovine skeletal muscle, as identified by dual luciferase reporter assays with the core regulatory region mapped to -129/+55 bp. Dual luciferase reporter assays, promoter deletion constructs, transcription factor binding site analysis, tissue expression analysis Animals Low 40362031

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. The American journal of pathology 283 15509545
2015 CDH2 and CDH11 act as regulators of stem cell fate decisions. Stem cell research 134 25771201
2018 FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts. Cell reports 84 29642003
2021 Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway. Journal of pain research 70 33574696
2022 Extracellular Vesicle-Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells. Cancer research 64 35149589
2015 miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition. Oncology reports 40 26706910
2012 Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes. Neuropathology and applied neurobiology 40 21722156
2008 CDH11 expression is associated with survival in patients with osteosarcoma. Cancer genomics & proteomics 40 18359978
2010 Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death. PLoS genetics 36 20421947
2019 Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo. BMC cancer 35 31248373
2015 Aberrant methylation of CDH11 predicts a poor outcome for patients with bladder cancer. Oncology letters 23 26622548
2019 EPHB6 mutation induces cell adhesion-mediated paclitaxel resistance via EPHA2 and CDH11 expression. Experimental & molecular medicine 21 31160603
2016 CDH11 inhibits proliferation and invasion in head and neck cancer. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 18 27397103
2020 CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients. Journal of gastrointestinal cancer 17 31407253
2019 Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum. Molecular brain 17 31046797
2011 Identification of quantitative trait loci influencing skeletal architecture in mice: emergence of Cdh11 as a primary candidate gene regulating femoral morphology. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 17 21638317
2024 YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation. Cancer letters 16 38871245
2018 CDH11 promotes liver fibrosis via activation of hepatic stellate cells. Biochemical and biophysical research communications 16 30509494
2014 Association of CDH11 with non-syndromic ASD. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 16 24839052
2019 A positive feedback loop consisting of C12orf59/NF-κB/CDH11 promotes gastric cancer invasion and metastasis. Journal of experimental & clinical cancer research : CR 15 30987656
2017 ADAMTSL5 and CDH11: putative epigenetic markers for therapeutic resistance in acute lymphoblastic leukemia. Hematology (Amsterdam, Netherlands) 15 28292214
2023 Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11/SOX9 expression. Molecular medicine (Cambridge, Mass.) 14 36809926
2017 Homozygous indel mutation in CDH11 as the probable cause of Elsahy-Waters syndrome. American journal of medical genetics. Part A 14 28988429
2021 Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells. Journal of Cancer 13 33391403
2017 Elsahy-Waters syndrome is caused by biallelic mutations in CDH11. American journal of medical genetics. Part A 13 29271567
2018 Gga-miR-205a Affecting Myoblast Proliferation and Differentiation by Targeting CDH11. Frontiers in genetics 12 30356692
2021 Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome. Human genetics 9 33811546
2021 Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies. Neuroscience bulletin 9 34523068
2023 FOXF1 attenuates TGF‑β1‑induced bronchial epithelial cell injury by inhibiting CDH11‑mediated Wnt/β‑catenin signaling. Experimental and therapeutic medicine 8 36798677
2018 A novel mutation in CDH11, encoding cadherin-11, cause Branchioskeletogenital (Elsahy-Waters) syndrome. American journal of medical genetics. Part A 8 30194892
2023 Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment. Biochemistry and biophysics reports 7 38034129
2018 Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. Pathology, research and practice 7 30401581
2024 Inhibition of CDH11 Activates cGAS-STING by Stimulating Branched Chain Amino Acid Catabolism and Mitigates Lung Metastasis of Adenoid Cystic Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 39739317
2021 CDH11 Regulates Adhesion and Transcellular Migration of Tongue Squamous Cell Carcinoma. OncoTargets and therapy 6 34295163
2023 Expression signature and molecular basis of CDH11 in OSCC detected by a combination of multiple methods. BMC medical genomics 5 37013637
2024 DNM3OS/miR-127-5p/CDH11, activates Wnt3a/β-catenin/LEF-1 pathway to form a positive feedback and aggravate spine facet joint osteoarthritis. Non-coding RNA research 3 38505310
2026 Circulating fibroblasts and neutrophils co-expressing CDH11+ and chemokine receptors in rheumatoid and psoriatic arthritis: a shared mechanism of 'arthritis spreading'? Frontiers in immunology 1 41624850
2025 Cloning and Transcriptional Activity Analysis of the Bovine CDH11 Gene Promoter: Transcription Factors Sp1 and GR Regulate Bovine CDH11 Expression. Animals : an open access journal from MDPI 1 40362031
2025 Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner. The Kaohsiung journal of medical sciences 1 40387410
2025 Targeting CDH11 with celecoxib and derivatives to suppress esophageal squamous cell carcinoma proliferation and invasion. Pathology, research and practice 1 40460640
2023 A Japanese patient with Teebi hypertelorism syndrome and a novel CDH11 EC1 domain variant. American journal of medical genetics. Part A 1 37646430
2026 USP14-mediated inhibition of CDH11 ubiquitination propels IL-1β-induced chondrocyte injury. Clinical rheumatology 0 41653235
2026 miR-205a mediated suppression of CDH11 disrupts Wnt/β-catenin signaling and impairs chondrocyte differentiation. Cell death discovery 0 42091868
2026 A positive feedback loop between CDH11 and TGF-β signaling regulates migration and invasion of gastric cancer. Translational oncology 0 42127732
2025 CDH11 Contributes to Bladder Cancer Progression via Regulation of Mitochondrial Energy Metabolism. Cancer medicine 0 41263259
2025 CDH11 Contributes to Airway Neutrophilic Inflammation in Severe Asthma via FGFR1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41329017

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