Affinage

Showing ITGAE — CD103 is a alias.

ITGAE

Integrin alpha-E · UniProt P38570

Length
1179 aa
Mass
130.2 kDa
Annotated
2026-06-10
100 papers in source corpus 31 papers cited in narrative 31 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGAE (CD103) is the αE subunit of the αEβ7 integrin that mediates adhesion of T cells and dendritic cells to E-cadherin on epithelial and tumor cells, controlling lymphocyte retention and effector function in epithelial tissues (PMID:10978890, PMID:30674537). On CD8+ T cells, CD103 promotes infiltration of epithelial compartments — CD103-deficient effector CD8 cells traffic to graft sites but fail to penetrate the epithelial layer (PMID:12370250) — and underlies the formation and tissue retention of CD103+ tissue-resident memory (TRM) cells, which arise from epithelium-infiltrating precursors under local IL-15 and TGF-β signaling (PMID:24162776, PMID:32439709). Its induction on CD8 T cells is driven by co-engagement of the TCR and the TGF-β1 receptor, which cooperatively activate the ITGAE promoter and enhancer through Smad2/3 and NFAT-1 (PMID:24477908); this axis is reinforced by Runx3 (PMID:16034110), retinoic-acid-dependent priming in mesenteric lymph nodes (PMID:36809399), and a CD103+ CTL-intrinsic autocrine TGF-β1 loop (PMID:31771983), and is negatively gated by Tcf1 and by the SKI proto-oncogene, which binds the Itgae locus and represses transcription via Smad4-dependent histone deacetylation (PMID:32268106, PMID:32612153). Beyond adhesion, CD103 functions as a TCR co-receptor: it associates with TCRα/β and CD3ζ to amplify ZAP70 phosphorylation and cytokine production (PMID:32974219), pairs transiently with CD61 at synaptic microclusters to enhance antitumor cytotoxicity (PMID:38561495), improves TCR antigen sensitivity in cancer-specific CTLs (PMID:31771983), and on γδ intraepithelial lymphocytes triggers extracellular granzyme A/B release upon E-cadherin ligation to drive enterocyte shedding (PMID:34861219). CD103 also marks a Batf3/Irf8/Flt3L-dependent dendritic-cell lineage specialized for antigen cross-presentation, CCR7-driven lymph-node migration, and induction of gut-homing, tolerogenic, and IgA-class-switched immune responses (PMID:20008528, PMID:20351058, PMID:21859845, PMID:25100743). CD103-mediated retention of cytotoxic TRM cells is pathogenic in autoimmune tissue injury, as anti-CD103 blockade ameliorates experimental Sjögren's syndrome (PMID:38777379).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2000 Medium

    Established the core ligand-receptor function: that αEβ7/CD103 binds E-cadherin to anchor intraepithelial CD8 T cells to epithelial surfaces, and that chemokine signaling tunes this adhesion.

    Evidence E-cadherin-Fc adhesion assays with CCL25/CCR9 stimulation and pertussis toxin inhibition

    PMID:10978890

    Open questions at the time
    • Adhesion measured in vitro on Fc fusion, not tissue context
    • No structural basis of the αE/E-cadherin interaction defined
  2. 2002 High

    Answered whether CD103 adhesion has an in vivo functional consequence, showing it is specifically required for CD8 effector infiltration of epithelial layers rather than for trafficking to the tissue.

    Evidence Reciprocal adoptive transfer of WT vs CD103-/- CD8 T cells in an islet allograft model

    PMID:12370250

    Open questions at the time
    • Does not address molecular signaling downstream of E-cadherin engagement
    • Limited to allograft setting
  3. 2005 High

    Identified the first transcription factor controlling CD103 expression, placing Runx3 upstream of αE induction during CD8 thymocyte development.

    Evidence Runx3 knockout and transgenic overexpression mouse models with thymic flow cytometry

    PMID:16034110

    Open questions at the time
    • Direct binding of Runx3 to the Itgae locus not shown
    • Relationship to TGF-β signaling unresolved at this stage
  4. 2005 High

    Distinguished CD103's role on dendritic cells from its role on T cells, showing CD103+ DCs imprint gut-homing and tolerogenic T cell programs.

    Evidence CD103-/- mice in T cell transfer colitis, Treg adoptive transfer, DC-T co-culture

    PMID:16216886

    Open questions at the time
    • Whether CD103 itself or a co-marker mediates DC function not separated
    • Molecular basis of CCR9 imprinting unaddressed
  5. 2010 High

    Defined the developmental program of the CD103+ DC lineage, establishing shared Batf3/Irf8 dependence linking nonlymphoid CD103+ DCs to lymphoid CD8α+ DCs.

    Evidence Batf3-/- and Irf8-/- mice across multiple tissues with viral challenge and expression profiling; extended by Flt3L/Id2/IRF8 and FLT3L/GM-CSF culture studies

    PMID:20008528 PMID:20351058 PMID:25100743

    Open questions at the time
    • Does not address CD103's own functional contribution within these DCs
    • Subset heterogeneity (CD11b+ vs CD11b-) only partially resolved
  6. 2011 High

    Assigned a specialized effector function to CD103+ DCs — selective transport and cross-presentation of apoptotic-cell antigen requiring TLR3.

    Evidence Batf3-/- mice, in vivo apoptotic antigen transport assays, TLR3 ligation, CTL readout

    PMID:21859845

    Open questions at the time
    • CD103 integrin function vs lineage marker role not dissected
    • Mechanism of selective apoptotic antigen capture unknown
  7. 2014 High

    Resolved the transcriptional logic of CD103 induction in CD8 T cells, mapping TGF-β1/TCR co-stimulation onto Smad2/3 and NFAT-1 acting at the human ITGAE promoter/enhancer.

    Evidence Human CTL clone system with promoter/enhancer mapping and transcription factor analysis

    PMID:24477908

    Open questions at the time
    • Direct factor occupancy at endogenous locus in primary cells not shown
    • Integration with Runx3 not mapped
  8. 2013 High

    Connected CD103 to tissue-resident memory biology, showing CD103+CD8+ TRM arise from epithelium-infiltrating precursors via local IL-15 and TGF-β.

    Evidence Skin infection model, parabiosis, cytokine blockade, transcriptional profiling

    PMID:24162776

    Open questions at the time
    • Whether CD103 is required for TRM formation vs a marker of it not separated here
    • Tissue specificity of the program incompletely defined
  9. 2009 Medium

    Extended CD103 function to the tumor microenvironment, linking TCR+TGF-β1-induced CD103 to E-cadherin engagement that retains CD8 T cells by recruiting CCR5 to the synapse.

    Evidence Adoptive transfer in NOD/SCID mice with immunological synapse and CCR5 recruitment analysis

    PMID:19638592

    Open questions at the time
    • Single-lab mechanistic synapse analysis
    • Generality across tumor types not established
  10. 2016 High

    Dissected how CD103+ DCs migrate to lymph nodes, defining a cell-intrinsic NR4A3-AKT-FOXO1-CCR7 axis governing migration and mitochondrial homeostasis.

    Evidence Nr4a3-/- mixed bone marrow chimeras, FOXO1/CCR7 analysis, AKT inhibition, in vivo challenges

    PMID:27820700

    Open questions at the time
    • Does not connect to CD103 integrin function per se
    • Whether axis operates in all CD103+ DC subsets unclear
  11. 2017 High

    Established TGFβR1 as a cell-intrinsic driver of intestinal CD103+CD11b+ DC differentiation, with downstream consequences for Treg and Th17 generation; complemented by TLR3/TICAM-1-dependent CD103+ DC control of IgA class switching.

    Evidence CD11c-Cre.Tgfbr1-fl/fl conditional KO with profiling and Treg assays; Batf3-/- and TLR3/TICAM-1 KO nasal immunization

    PMID:28612840 PMID:28931816

    Open questions at the time
    • Role of CD103 protein vs the DC subset not isolated
    • Link between DC TGF-β signaling and αE expression mechanistic detail limited
  12. 2019 High

    Demonstrated CD103's ligand-dependent antitumor requirement and an autocrine maintenance loop, showing tumor E-cadherin and CTL-intrinsic active TGF-β1 sustain CD103-driven cytotoxicity and TCR sensitivity.

    Evidence E-cadherin+ B16F10 melanoma in Rag1-/- and CD103-/- mice; TCR-matched CD103+/CD103- CTL pairs

    PMID:30674537 PMID:31771983

    Open questions at the time
    • Quantitative contribution of CD103 vs other adhesion molecules unresolved
    • Autocrine loop characterized in single lab
  13. 2020 High

    Separated CD103's adhesion role from motility (CD49a) in lung TRM and identified two transcriptional repressors of CD103 — Tcf1 and SKI — that directly bind the Itgae locus, with SKI repressing via Smad4-dependent histone acetylation.

    Evidence Influenza motility assays; Tcf7-cKO with ChIP; ectopic SKI with ChIP and histone acetylation analysis

    PMID:32268106 PMID:32439709 PMID:32612153

    Open questions at the time
    • Interplay between activating (Smad2/3/NFAT/Runx3) and repressive (Tcf1/SKI) factors at the locus not integrated
    • Chromatin dynamics over T cell differentiation incompletely mapped
  14. 2021 High

    Defined CD103 as a TCR co-receptor and elaborated effector mechanisms across epithelial settings — TCR/CD3ζ association amplifying ZAP70, γδ IEL granzyme release upon E-cadherin ligation, and CD103-dependent IEL anti-tumor surveillance; also showed β7 availability and CD4 selection consequences.

    Evidence Co-IP and ZAP70 assays; intravital microscopy and granzyme ELISA in γδ IEL; APCmin tumor model with organoid co-culture; forced-expression and Runx3-KO mouse models

    PMID:32974219 PMID:33515805 PMID:34129058 PMID:34861219

    Open questions at the time
    • Co-IP TCR association is single-lab without reciprocal/structural validation
    • How E-cadherin ligation transduces to granzyme release mechanistically unclear
  15. 2023 Medium

    Refined upstream control of CD103+ TRM by showing retinoic-acid priming in mesenteric lymph nodes licenses the program independent of gut homing, and that itaconate suppresses CD103 induction by blocking RUNX3 DNA demethylation.

    Evidence MLN- vs spleen-primed adoptive transfer with retinoic acid blockade and CCR9 KO; 4-OI treatment with RUNX3 methylation analysis and IRG1 KO

    PMID:36809399 PMID:37505225

    Open questions at the time
    • Itaconate-RUNX3 link is single-lab
    • Metabolic regulation of the Itgae locus only partially defined
  16. 2024 Medium

    Identified CD61 as a transient synaptic partner of CD103 modulating TCR signaling and antitumor cytotoxicity, and validated CD103 as a therapeutic target for retaining pathogenic TRM in autoimmunity.

    Evidence Synaptic co-localization imaging with TCR signaling and tumor growth assays; intraglandular anti-CD103 mAb in experimental Sjögren's syndrome

    PMID:38561495 PMID:38777379

    Open questions at the time
    • CD103-CD61 pairing characterized in single study without structural detail
    • Therapeutic blockade tested only in one autoimmune model

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the activating (Smad2/3, NFAT-1, Runx3, retinoic acid) and repressive (Tcf1, SKI/Smad4) inputs are integrated at the Itgae locus to set CD103 levels in distinct T cell and DC contexts, and the structural basis of CD103's E-cadherin and TCR/CD3ζ interactions, remain unresolved.
  • No structural model of αEβ7/E-cadherin binding in the corpus
  • Combined regulatory logic at the locus not reconstituted
  • TCR co-receptor mechanism lacks reciprocal/structural validation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 5 GO:0060089 molecular transducer activity 2
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-168256 Immune System 4 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-162582 Signal Transduction 3
Partners
CD3ZCDH1ITGB3 (CD61)ITGB7TCR ALPHA/BETA
Complex memberships
TCR/CD3 complex (CD103-associated)αEβ7 integrin

Evidence

Reading pass · 31 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 The αE(CD103)β7 integrin binds E-cadherin on epithelial cells, mediating T cell adhesion to epithelial surfaces. CCL25 (via CCR9) induces transient, dose-dependent and pertussis toxin-sensitive CD103-mediated adhesion of CD8+ intraepithelial lymphocytes to E-cadherin. Adhesion assay using murine E-cadherin-Fc fusion protein; pertussis toxin inhibition Current opinion in cell biology Medium 10978890
2002 CD103 expression on CD8+ T cells is required for intragraft migration into epithelial compartments and destruction of pancreatic islet allografts; CD103-/- CD8 cells trafficked normally to the graft site but failed to infiltrate the islet itself, demonstrating CD103's role in promoting CD8 effector infiltration of epithelial layers. Genetic knockout (CD103-/- mice), adoptive transfer of wild-type vs CD103-/- CD8 T cells, in vivo islet allograft transplantation model The Journal of experimental medicine High 12370250
2004 CCR9 signaling via its ligand CCL25 promotes induction of CD103 on CD8+ T cells upon entry into the small intestinal epithelium; CCR9-/- CD8 T cells showed significant delay in CD103 induction at this site. CCR9-/- mouse model, adoptive transfer, flow cytometry of intestinal intraepithelial lymphocytes European journal of immunology Medium 15368288
2005 The transcription factor Runx3 is necessary for CD103 (integrin αE) induction during development of CD8 single-positive thymocytes; Runx3 deletion reduces CD103 expression, and Runx3 overexpression upregulates CD103 on CD8 SP T cells and a subpopulation of CD4 SP T cells. Runx3 knockout and transgenic overexpression mouse models, flow cytometry of thymic T cell subsets Journal of immunology High 16034110
2005 CD103 expression on dendritic cells (not T cells) is required for T regulatory cell-mediated control of colitis; CD103+ DCs (but not CD103- DCs) promote expression of gut-homing receptor CCR9 on T cells, while CD103- DCs promote IFN-γ-producing T cell differentiation. CD103-/- mice, T cell transfer colitis model, adoptive transfer of CD4+CD25+ Tregs, in vitro DC-T cell co-culture assays The Journal of experimental medicine High 16216886
2009 CD103+ DCs in nonlymphoid tissues are exclusively derived from pre-DCs under control of Flt3 ligand, Id2, and IRF8, sharing the same precursor and differentiation program as lymphoid organ CD8+ DCs; in contrast, lamina propria CD103+CD11b+ DCs develop independently of Id2 and IRF8. Flt3-/-, Id2-/-, and IRF8-/- mouse models, bone marrow reconstitution, flow cytometry of DC subsets across tissues The Journal of experimental medicine High 20008528
2009 CD103 expression on tumor-infiltrating CD8+ T cells is triggered by co-engagement of TCR and TGF-β1 receptor in the tumor microenvironment; once induced, αEβ7 integrin interaction with E-cadherin on tumor cells recruits CCR5 to the immunological synapse, inhibiting T cell sensitivity to CCL5 chemotactic gradient and promoting T cell retention at the tumor site. Adoptive transfer in NOD/SCID mice, in vivo TCR + TGF-β1 co-stimulation, immunological synapse analysis, CCR5 recruitment assays Cancer research Medium 19638592
2010 The transcription factor Batf3 is required for development of CD103+CD11b- DCs in lung, intestine, mesenteric lymph nodes, dermis, and skin-draining lymph nodes; Batf3-/- mice lack these cells and show reduced CD8 T cell priming after pulmonary viral infection, establishing a developmental relationship between lymphoid organ CD8α+ DCs and nonlymphoid CD103+ DCs via shared dependence on Batf3 and Irf8. Batf3-/- and Irf8-/- mouse models, flow cytometry across tissues, viral infection challenge, gene expression profiling The Journal of experimental medicine High 20351058
2011 CD103+ pulmonary DCs selectively acquire and transport apoptotic cell-associated antigen to draining lymph nodes and cross-present it to CD8 T cells; this selective role requires TLR3 expression on CD103+ DCs, and TLR3 ligation enhances CTL responses to apoptotic cell-associated antigen. Batf3-/- mice lacking CD103+ DCs, in vivo apoptotic cell transport assays, TLR3 ligation experiments, CTL response measurement The Journal of experimental medicine High 21859845
2013 CD103+CD8+ tissue-resident memory T cells in skin develop from KLRG1- epithelium-infiltrating precursor cells; their formation requires a combination of epithelial entry plus local IL-15 and TGF-β signaling, and these cells acquire a unique transcriptional profile distinct from circulating memory cells. Mouse skin infection model, parabiosis, IL-15 and TGF-β blocking experiments, transcriptional profiling, flow cytometry Nature immunology High 24162776
2014 The transcription factors Smad2/3 and NFAT-1 are critical regulators of CD103 induction in CD8 T cells; TGF-β1 and TCR co-engagement cooperatively drive CD103 (ITGAE gene) expression through promoter and enhancer elements of the human ITGAE gene. Human CTL clone system, Smad2/3 and NFAT-1 transcription factor analysis, ITGAE promoter/enhancer mapping, TGF-β1 and TCR stimulation Journal of immunology High 24477908
2014 CD103+ DC development in vitro requires prolonged culture with both FLT3L and GM-CSF acting on DC precursors and differentiating CD103+ DCs; these cells develop in a Batf3- and Irf8-dependent fashion, cross-present cell-associated antigens, respond to TLR3 stimulation, and upregulate CCR7 upon maturation enabling lymph node migration. Bone marrow culture differentiation, Batf3-/- and Irf8-/- genetic validation, antigen cross-presentation assays, TLR3 stimulation, CCR7 expression and migration assays Blood High 25100743
2015 CD103-/- mice develop exacerbated lung inflammation with increased eosinophilic infiltration and defective resolution phase in asthma models, demonstrating CD103 plays a role in controlling airway inflammation severity. CD103-/- mice in ovalbumin and house dust mite asthma models, bronchoalveolar lavage analysis, histology, flow cytometry American journal of physiology. Lung cellular and molecular physiology Medium 25681437
2016 The transcription factor NR4A3 is cell-intrinsically required for CD103+ DC migration to lymph nodes by regulating surface CCR7 expression on CD103+ DCs (but not T cells); NR4A3 maintains FOXO1 protein levels via an AKT-dependent mechanism, which in turn drives CCR7 expression; NR4A3 is also required for homeostatic mitochondrial function in CD103+ DCs. Nr4a3-/- mice, mixed bone marrow chimeras (cell-intrinsic test), CCR7 expression flow cytometry, FOXO1 protein analysis, AKT inhibition, TLR7 agonist and in vivo infection challenges The Journal of clinical investigation High 27820700
2017 TGFβR1 signaling has an indispensable cell-intrinsic role in the development of intestinal CD103+CD11b+ DCs; deletion of Tgfbr1 results in markedly fewer CD103+CD11b+ DCs and a reciprocal increase in CD103-CD11b+ DCs, reflecting defective differentiation from CD103-CD11b+ intermediaries rather than isolated loss of CD103 expression; absence of these DCs reduces generation of FoxP3+ regulatory T cells and numbers of endogenous Th17 cells. CD11c-Cre.Tgfbr1-fl/fl conditional KO mice, transcriptional profiling, in vitro and in vivo FoxP3+ Treg generation assays Nature communications High 28931816
2017 Nasal CD103+ DCs are indispensable for TLR3/TICAM-1-mediated IgA class switching and vaccine-specific IgA production; polyI:C is endocytosed into CD103+ DCs, activating TGF-β signaling and activation-induced cytidine deaminase, leading to T cell-dependent IgA production preferentially over IgG. Batf3-/- mice lacking CD103+ DCs, TLR3/TICAM-1 knockout mice, nasal immunization, IgA/IgG measurement, genomic recombination analysis Mucosal immunology High 28612840
2018 CD103 mediates adhesion of intraepithelial lymphocytes to E-cadherin on dendritic cells (via membrane-bound TGF-β signaling from DCs), and endometrial DCs from postmenopausal women induce CD103 expression on allogeneic naïve CD8+ T cells through this membrane-bound TGF-β mechanism. Ex vivo DC-T cell co-culture from hysterectomy tissues, TGFβ signaling blockade, flow cytometry Aging cell Medium 29455474
2019 E-cadherin expression on tumor cells is required for CD103-mediated antitumor immunity in vivo; transplantation of E-cadherin-expressing B16F10 melanoma into CD103-/- mice abrogated the tumor growth delay seen with E-cadherin-expressing tumors, establishing that the antitumor response against E-cadherin+ tumors is both immune-mediated and CD103-dependent. E-cadherin-expressing B16F10 mouse melanoma model, Rag1-/- and CD103-/- mice, tumor growth and survival measurements Cancer research High 30674537
2019 CD103+CD8+ tumor-infiltrating T cells produce and respond to TGFβ in a self-regulatory loop: differentiated CD103+ cancer-specific CTLs express the active form of TGFβ1 to self-maintain CD103 expression without relying on external TGFβ1-producing cells; CD103 on CTLs improves TCR antigen sensitivity enabling faster cancer recognition and rapid cytotoxicity. TCR-matched CD103+ and CD103- cancer-specific CTL pairs, in vitro functional assays, ex vivo immunophenotyping Cancer immunology research Medium 31771983
2020 CD103 (but not CD49a) supports adhesion of tissue-resident memory CD8 T cells in the lung; CD49a facilitates locomotion of virus-specific CD8 T cells both in vitro and in vivo, whereas CD103 and CD49a have distinct and separable functions in TRM biology post-influenza infection. Influenza virus infection mouse model, in vitro and in vivo motility assays, flow cytometry of CD103 and CD49a expression kinetics Proceedings of the National Academy of Sciences of the United States of America Medium 32439709
2020 T cell factor 1 (Tcf1) directly binds to the Itgae locus (encoding CD103) and partly inhibits TGF-β-induced CD103 expression; T-cell-specific ablation of Tcf7 (encoding Tcf1) enhances CD103 protein expression in TRM cells and increases TRM cell numbers, demonstrating that Tcf1 suppresses CD103+ lung TRM cell development. Tcf7-conditional KO mice, ChIP (Tcf1 binding to Itgae locus), TGF-β signaling abrogation in vivo, flow cytometry Cell reports High 32268106
2020 The SKI proto-oncogene is recruited to the Itgae loci and directly suppresses CD103 transcription by regulating histone acetylation in a Smad4-dependent manner; ectopic SKI expression restricts CD103 expression in CD8+ T cells in vitro and in vivo, revealing a TGFβ-SKI-Smad4 pathway that controls resident CD103+CD8+ T cell generation. Ectopic SKI expression in vitro and in vivo, ChIP (SKI at Itgae locus), histone acetylation analysis, Smad4-dependent epistasis, viral infection model Cellular & molecular immunology High 32612153
2021 CD103/E-cadherin ligation on γδ intraepithelial lymphocytes triggers extracellular release of granzymes A and B (but not perforin), facilitating TNF-mediated shedding of apoptotic enterocytes; CD103 knockout or blockade significantly reduced LPS-induced cell shedding in vivo. Intravital microscopy in GFP γδ T cell reporter mice, CD103-/- mice, anti-CD103 blocking antibody, granzyme ELISA from ex vivo-stimulated γδ IELs, ZO-1/caspase-3 immunostaining Gastroenterology High 34861219
2021 CD103 integrin availability for surface expression is constrained by the availability of integrin β7 (its heterodimerization partner); forced surface expression of CD103 does not significantly alter thymic development of conventional T cells but severely impairs generation of MHC-II-restricted TCR transgenic CD4 T cells, revealing CD103 involvement in CD4 T cell selection; the regulatory mechanism of CD103 expression is distinct between CD4 and CD8 T cells with Runx3 playing an important but non-essential role. Multiple genetically engineered mouse models including Runx3 KO, forced CD103 expression transgenics, TCR transgenic crosses, flow cytometry, thymic developmental analysis Cellular and molecular life sciences High 34129058
2021 CD103 interacts with TCR α/β and CD3ζ (shown by immunoprecipitation); CD103 activation enhances phosphorylation of ZAP70 induced by TCR signaling, and blocking CD103 with a neutralizing antibody reduces T cell proliferation and cytokine (IFN-γ, TNF, IL-17) production in CD103+CD4+ T cells co-cultured with antigen-primed DCs. Co-immunoprecipitation (CD103 with TCR α/β and CD3ζ), ZAP70 phosphorylation assay, anti-CD103 neutralizing antibody blockade in DC-T cell co-culture Frontiers in cellular and infection microbiology Medium 32974219
2021 CD103-mediated E-cadherin contact between intraepithelial lymphocytes and intestinal epithelial cells is required for anti-tumor IEL activity; genetic deletion of CD103 decreased frequency of IEL-epithelial interactions and increased small intestinal tumor numbers; wild-type IEL-mediated reduction in tumor organoid viability was CD103-dependent and required cell-to-cell contact. CD103-/- mice in APCmin spontaneous tumor model, in vivo live-imaging, in vitro co-culture with tumor organoids, DPE-GFP reporter mice Cellular and molecular gastroenterology and hepatology High 33515805
2022 Intestinal CD103+ TRM cells, when fate-mapped, remain organ-confined during secondary infection, fail to re-expand, and do not autonomously maintain their population; CD103- TRM cells are the primary responders to secondary infection and give rise to new CD103+ cells de novo; CD103+ TRM become fully activated by inflammation alone (without antigen), whereas CD103- cells require both antigen and inflammation. Two novel mouse models: CD103+ fate-mapping (stable marking) and CD103- T cell depletion; Yersinia pseudotuberculosis secondary infection model; transcriptional profiling; in vitro and in vivo TCR reactivation assays Science immunology High 36332012
2023 Retinoic acid signaling during T cell priming in mesenteric lymph nodes (MLN) licenses CD103+ TRM cell differentiation in the intestine independently of CCR9-mediated gut homing; T cells primed in the spleen are impaired in CD103+ TRM differentiation after intestinal entry, while MLN priming initiates a CD103+ TRM gene signature. Adoptive transfer comparing MLN-primed vs spleen-primed T cells, retinoic acid signaling blockade, CCR9-deficient T cells, gene expression profiling The Journal of experimental medicine High 36809399
2023 Itaconate (via its derivative 4-OI) inhibits the induction and effector functions of CD103+ TRM cells in vitro by blocking DNA demethylation of RUNX3 in CD8+ T cells; this reduces intrahepatic CD103+ TRM and ameliorates liver injury in murine PSC models. 4-OI treatment in vitro and in vivo (PSC murine models), RUNX3 DNA methylation analysis, IRG1 KO mice, flow cytometry Hepatology Medium 37505225
2024 CD103 pairs transiently with CD61 at synaptic microclusters of T cells; this CD61 colocalization with TCR further modulates downstream TCR signaling, improving antitumor cytotoxicity and promoting physiological tumor growth control. Co-localization imaging of CD61 and CD103 at immunological synapses, TCR signaling assays, in vivo tumor growth experiments Nature immunology Medium 38561495
2024 Intraglandular anti-CD103 monoclonal antibody blockade in an experimental Sjögren's syndrome mouse model reduced CD103+ TRM cells, reduced glandular damage, and improved salivary flow, demonstrating a pathogenic role for CD103 in retaining/maintaining cytotoxic TRM cells in inflamed salivary glands. Experimental SS (ESS) mouse model, intraglandular anti-CD103 mAb injection, flow cytometry, histology, salivary flow measurement Annals of the rheumatic diseases Medium 38777379

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nature immunology 1109 24162776
2016 Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity 1002 27096321
2016 Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer cell 834 27424807
2018 Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nature communications 747 30006565
2010 Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. The Journal of experimental medicine 610 20351058
2009 The origin and development of nonlymphoid tissue CD103+ DCs. The Journal of experimental medicine 604 20008528
2005 Essential role for CD103 in the T cell-mediated regulation of experimental colitis. The Journal of experimental medicine 392 16216886
2018 TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer cell 327 29316433
2020 Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity 291 32610077
2011 CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. The Journal of experimental medicine 253 21859845
2010 Development and functional specialization of CD103+ dendritic cells. Immunological reviews 215 20193025
2019 A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer. Cancer immunology research 201 30872264
2019 CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. Molecular cancer 189 30975145
2014 Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 184 25100743
2016 CD103 and Intratumoral Immune Response in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 134 27267849
2022 Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model. Journal of hepatology 131 35367532
2000 T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines. Current opinion in cell biology 124 10978890
2021 Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade. Journal for immunotherapy of cancer 121 33827905
2019 CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells. Nature immunology 113 31591568
2020 TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America 109 32439709
2005 Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950) 108 16034110
2019 FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nature communications 105 30683885
2020 Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. Journal for immunotherapy of cancer 93 32273347
2017 TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine. Nature communications 90 28931816
2004 CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes. European journal of immunology 81 15368288
2009 Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer research 79 19638592
2023 CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma. Nature cancer 78 37081259
2002 CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells. The Journal of experimental medicine 78 12370250
2023 Tertiary Lymphoid Structure-Associated B Cells Enhance CXCL13+CD103+CD8+ Tissue-Resident Memory T-Cell Response to Programmed Cell Death Protein 1 Blockade in Cancer Immunotherapy. Gastroenterology 69 38445519
2014 Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 67 24477908
2020 T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell reports 66 32268106
2021 The Clinical Significance of Hepatic CD69+ CD103+ CD8+ Resident-Memory T Cells in Autoimmune Hepatitis. Hepatology (Baltimore, Md.) 65 33554350
2014 Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 59 24550510
2022 CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Science immunology 58 36332012
2020 KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease. Frontiers in immunology 53 32477365
2023 Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation. The Journal of experimental medicine 52 36809399
2015 CD103+ Dendritic Cells Elicit CD8+ T Cell Responses to Accelerate Kidney Injury in Adriamycin Nephropathy. Journal of the American Society of Nephrology : JASN 52 26376858
2006 Expression of CD103 identifies human regulatory T-cell subsets. The Journal of allergy and clinical immunology 52 17137867
2022 NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. Journal of hepatology 49 35753523
2019 Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer research 49 30674537
2017 Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation. Microbiome 49 28438184
2017 CD103+ Dendritic Cell Function Is Altered in the Colons of Patients with Ulcerative Colitis. Inflammatory bowel diseases 48 28700533
2021 TGF-β: Many Paths to CD103+ CD8 T Cell Residency. Cells 45 33922441
2019 Intestinal CD103+CD4+ and CD103+CD8+ T-Cell Subsets in the Gut of Inflammatory Bowel Disease Patients at Diagnosis and During Follow-up. Inflammatory bowel diseases 45 30918941
2013 Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. PloS one 44 23691170
2019 Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses. Cancer immunology research 43 31771983
2018 Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma. Cancer immunology, immunotherapy : CII 42 30361882
2018 Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging cell 41 29455474
2022 Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool. Science immunology 40 36332011
2021 Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs. European journal of immunology 40 34505280
2021 γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release. Gastroenterology 40 34861219
2020 CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function. Nature communications 39 33268774
2017 A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells. The Journal of investigative dermatology 38 28941625
2020 CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma. Journal for immunotherapy of cancer 37 32527931
2023 Intratumoral CD103+ CD8+ T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma. Cancer communications (London, England) 36 37658605
2021 Implication of CD69+ CD103+ tissue-resident-like CD8+ T cells as a potential immunotherapeutic target for cholangiocarcinoma. Liver international : official journal of the International Association for the Study of the Liver 36 33548061
2015 Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ. Journal of immunology (Baltimore, Md. : 1950) 36 25712214
2008 Alloantigen-induced regulatory CD8+CD103+ T cells. Human immunology 36 18822329
2017 Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production. Mucosal immunology 35 28612840
2015 Pulmonary CD103 expression regulates airway inflammation in asthma. American journal of physiology. Lung cellular and molecular physiology 35 25681437
2009 Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. American journal of clinical pathology 34 19289595
2018 Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut. JCI insight 32 29515025
2015 Integrin αE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. The Journal of investigative dermatology 32 26203637
2022 CD103+CD8+ tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer. British journal of cancer 31 35165401
2016 The transcription factor NR4A3 controls CD103+ dendritic cell migration. The Journal of clinical investigation 31 27820700
2021 Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal immunology 30 33654213
2018 Sex-based differences in CD103+ dendritic cells promote female-predominant Th2 cytokine production during allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 29 29288569
2021 Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cellular and molecular gastroenterology and hepatology 28 33515805
2023 CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden. Journal for immunotherapy of cancer 26 36792124
2021 Integrin αE(CD103)β7 in Epithelial Cancer. Cancers 26 34944831
2019 Flt3 inhibition alleviates chronic kidney disease by suppressing CD103+ dendritic cell-mediated T cell activation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 24 30590794
2023 Tertiary lymphoid structure-associated B cells enhance CXCL13+CD103+CD8+Trm cell response to PD-1 blockade in gastric cancer. Gastroenterology 23 39491204
2020 Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients. Oncoimmunology 22 33312758
2022 TIGIT blockade enhances tumor response to radiotherapy via a CD103 + dendritic cell-dependent mechanism. Cancer immunology, immunotherapy : CII 21 35794399
2019 Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205. Frontiers in immunology 21 31921114
2024 CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade. Annals of the rheumatic diseases 20 38777379
2019 Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis. Journal of immunology (Baltimore, Md. : 1950) 20 31712385
2023 Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa. The Journal of experimental medicine 19 37097449
2021 Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer. Cancer immunology, immunotherapy : CII 19 34767045
2023 PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy. International immunopharmacology 18 38150880
2021 CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation. Allergy 18 34658046
2020 STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer. Cancers 18 31947933
2016 Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence 18 27191829
2023 Itaconate inhibits CD103 + T RM cells and alleviates hepatobiliary injury in mouse models of primary sclerosing cholangitis. Hepatology (Baltimore, Md.) 17 37505225
2018 T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103+ Memory Status of CD8 T Cells in the Brain. Frontiers in immunology 17 29922298
2016 Distinct recirculation potential of CD69+CD103- and CD103+ thymic memory CD8+ T cells. Immunology and cell biology 17 27328704
2020 Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer. International journal of molecular sciences 16 32471032
2022 Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis. Cell reports 15 36384110
2018 Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma. Oncoimmunology 15 30288359
2016 Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103+ Dendritic Cells Confers Transient Susceptibility to Tuberculosis. Infection and immunity 15 27481246
2014 IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa. Journal of immunology (Baltimore, Md. : 1950) 15 25527788
2024 Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. Nature immunology 14 38561495
2021 PD-1 Expression Defines Epidermal CD8+CD103+ T Cells Preferentially Producing IL-17A and Using Skewed TCR Repertoire in Psoriasis. The Journal of investigative dermatology 14 33845077
2021 The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells. Cellular and molecular life sciences : CMLS 14 34129058
2020 The SKI proto-oncogene restrains the resident CD103+CD8+ T cell response in viral clearance. Cellular & molecular immunology 14 32612153
2020 CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4+ T Cell in Helicobacter pylori-Positive Gastritis. Frontiers in cellular and infection microbiology 14 32974219
2014 Essential role for CD103+ cells in the pathogenesis of spondyloarthritides. Joint bone spine 14 25241337
2024 Tumor-Infiltrating CD103+ Tissue-Resident Memory T Cells and CD103-CD8+ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease. Clinical cancer research : an official journal of the American Association for Cancer Research 13 37874322
2023 IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells. Frontiers in immunology 13 37006318
2020 CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs. Cell reports 13 32209473

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