- Length
- 467 aa
- Mass
- 54.0 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic findings about CCDC174 in the available literature (corpus appears contaminated with off-target papers).
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2005 | Towards a proteome-scale map of the human protein-protein interaction network. | Nature | 2090 | 16189514 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 1993 | CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases. | Cell | 1271 | 8431946 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2002 | Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. | Proceedings of the National Academy of Sciences of the United States of America | 686 | 12370430 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2018 | High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. | Molecular cell | 580 | 29395067 |
| 2001 | Biochemical characterization of the human copper transporter Ctr1. | The Journal of biological chemistry | 476 | 11734551 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 2012 | CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis. | Proceedings of the National Academy of Sciences of the United States of America | 431 | 23132950 |
| 1998 | Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. | Proceedings of the National Academy of Sciences of the United States of America | 348 | 9560288 |
| 2021 | A proximity-dependent biotinylation map of a human cell. | Nature | 339 | 34079125 |
| 2001 | Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. | Proceedings of the National Academy of Sciences of the United States of America | 339 | 11391005 |
| 2001 | The copper transporter CTR1 provides an essential function in mammalian embryonic development. | Proceedings of the National Academy of Sciences of the United States of America | 312 | 11391004 |
| 2006 | Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. | Cell metabolism | 248 | 16950140 |
| 2003 | Biochemical and functional analysis of CTR1, a protein kinase that negatively regulates ethylene signaling in Arabidopsis. | The Plant journal : for cell and molecular biology | 236 | 12535337 |
| 2003 | Localization of the Raf-like kinase CTR1 to the endoplasmic reticulum of Arabidopsis through participation in ethylene receptor signaling complexes. | The Journal of biological chemistry | 228 | 12821658 |
| 2009 | The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. | American journal of physiology. Renal physiology | 213 | 19144690 |
| 2002 | Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. | The Journal of biological chemistry | 210 | 12177073 |
| 1998 | A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. | Nucleic acids research | 205 | 9776767 |
| 2004 | C-terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins involved in copper trafficking. | Journal of the American Chemical Society | 204 | 15012137 |
| 2015 | A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. | eLife | 198 | 26673895 |
| 2004 | Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. | Molecular cancer therapeutics | 197 | 15634647 |
| 2002 | The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae. | Molecular pharmacology | 195 | 12391279 |
| 2006 | Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status. | The Journal of nutrition | 177 | 16365053 |
| 2004 | Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY/MYB transcription factors, COI1 and CTR1 in N-mediated resistance to tobacco mosaic virus. | The Plant journal : for cell and molecular biology | 173 | 15144381 |
| 2006 | Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. | Proceedings of the National Academy of Sciences of the United States of America | 161 | 16501047 |
| 2000 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. | Genome research | 161 | 11042152 |
| 2018 | MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. | Molecular cell | 152 | 30415952 |
| 2004 | Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter. | The Journal of biological chemistry | 146 | 14976198 |
| 1997 | Homeostatic regulation of copper uptake in yeast via direct binding of MAC1 protein to upstream regulatory sequences of FRE1 and CTR1. | The Journal of biological chemistry | 145 | 9211922 |
| 2016 | NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells. | Oncotarget | 143 | 27270317 |
| 2022 | Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. | Nature cell biology | 139 | 35027734 |
| 2010 | Role of the copper transporter, CTR1, in platinum-induced ototoxicity. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 138 | 20631178 |
| 2017 | RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. | BMC biology | 135 | 29117863 |
| 2022 | Human transcription factor protein interaction networks. | Nature communications | 123 | 35140242 |
| 2005 | The mechanism of copper uptake mediated by human CTR1: a mutational analysis. | The Journal of biological chemistry | 122 | 16135512 |
| 2010 | Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. | The Journal of biological chemistry | 121 | 20699218 |
| 2019 | The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. | Nature communications | 115 | 30737378 |
| 2011 | Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1. | Journal of the American Chemical Society | 113 | 21375246 |
| 2013 | Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. | Proceedings of the National Academy of Sciences of the United States of America | 112 | 24167251 |
| 2019 | X-ray structures of the high-affinity copper transporter Ctr1. | Nature communications | 110 | 30918258 |
| 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | Molecular medicine (Cambridge, Mass.) | 108 | 20379614 |
| 2014 | How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1. | Annals of the New York Academy of Sciences | 106 | 24697869 |
| 2007 | Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1. | Journal of experimental botany | 92 | 18000017 |
| 2003 | Ctr1 and its role in body copper homeostasis. | The international journal of biochemistry & cell biology | 83 | 12531240 |
| 2007 | Distinct mechanisms for Ctr1-mediated copper and cisplatin transport. | The Journal of biological chemistry | 81 | 17627943 |
| 2013 | The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. | The international journal of biochemistry & cell biology | 79 | 23391749 |
| 2002 | LeCTR1, a tomato CTR1-like gene, demonstrates ethylene signaling ability in Arabidopsis and novel expression patterns in tomato. | Plant physiology | 78 | 12427980 |
| 2014 | Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer. | Lung cancer (Amsterdam, Netherlands) | 77 | 24792335 |
| 2008 | Deletion of hepatic Ctr1 reveals its function in copper acquisition and compensatory mechanisms for copper homeostasis. | American journal of physiology. Gastrointestinal and liver physiology | 76 | 19095764 |
| 2015 | EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary Cancer. | PloS one | 73 | 25927922 |
| 2008 | Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper. | The Journal of biological chemistry | 71 | 19088072 |
| 2013 | CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells. | PloS one | 70 | 24039729 |
| 2014 | The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) | 68 | 24703712 |
| 2004 | Evidence that CTR1-mediated ethylene signal transduction in tomato is encoded by a multigene family whose members display distinct regulatory features. | Plant molecular biology | 68 | 15284494 |
| 2022 | Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery. | Nature communications | 65 | 35831314 |
| 2016 | Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu⁺ uptake system. | Journal of cell science | 65 | 26945057 |
| 2018 | NEAT1 acts as an inducer of cancer stem cell-like phenotypes in NSCLC by inhibiting EGCG-upregulated CTR1. | Journal of cellular physiology | 63 | 29152741 |
| 2012 | Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients. | Lung cancer (Amsterdam, Netherlands) | 62 | 22516052 |
| 2004 | Cloning, expression pattern and essentiality of the high-affinity copper transporter 1 (ctr1) gene in zebrafish. | Gene | 61 | 15019990 |
| 2015 | Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana. | The Journal of biological chemistry | 60 | 25814663 |
| 2016 | The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1. | Biophysical journal | 59 | 26745413 |
| 2004 | Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: requirement for the extracellular methionine-rich clusters. | The Journal of biological chemistry | 59 | 15326162 |
| 2018 | Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma. | Oncotarget | 58 | 29507693 |
| 2018 | Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop. | Phytomedicine : international journal of phytotherapy and phytopharmacology | 58 | 30195880 |
| 2015 | Copper uptake by DMT1: a compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells. | Metallomics : integrated biometal science | 57 | 26067577 |
| 2004 | Cellular pharmacology of cisplatin in relation to the expression of human copper transporter CTR1 in different pairs of cisplatin-sensitive and -resistant cells. | Biochemical pharmacology | 57 | 15194000 |
| 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. | Genome research | 57 | 15342556 |
| 2016 | Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivity. | Metallomics : integrated biometal science | 54 | 27157188 |
| 2010 | Ctr1 transports silver into mammalian cells. | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) | 54 | 20569931 |
| 2003 | The Candida albicans CTR1 gene encodes a functional copper transporter. | Microbiology (Reading, England) | 53 | 12777486 |
| 2020 | EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells. | Journal of cellular physiology | 47 | 31943177 |
| 2020 | RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. | Proceedings of the National Academy of Sciences of the United States of America | 47 | 32513696 |
| 2018 | SOX9/miR-130a/CTR1 axis modulates DDP-resistance of cervical cancer cell. | Cell cycle (Georgetown, Tex.) | 47 | 29099271 |
| 2022 | NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. | Nature immunology | 46 | 36138187 |
| 2008 | LeCTR2, a CTR1-like protein kinase from tomato, plays a role in ethylene signalling, development and defence. | The Plant journal : for cell and molecular biology | 46 | 18346193 |
| 2018 | The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1. | Metallomics : integrated biometal science | 44 | 30489586 |
| 2016 | Copper Transporter-CTR1 Expression and Pathological Outcomes in Platinum-treated Muscle-invasive Bladder Cancer Patients. | Anticancer research | 42 | 26851002 |
| 2013 | Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. | Neurobiology of aging | 42 | 23827522 |
| 2012 | Claudin-3 and claudin-4 regulate sensitivity to cisplatin by controlling expression of the copper and cisplatin influx transporter CTR1. | Molecular pharmacology | 42 | 23053666 |
| 2022 | Newly identified disorder of copper metabolism caused by variants in CTR1, a high-affinity copper transporter. | Human molecular genetics | 41 | 35913762 |
| 2016 | Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. | The Journal of biological chemistry | 41 | 27143361 |
| 2015 | The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. | Cell reports | 40 | 25683716 |
| 2012 | Arabidopsis RTE1 is essential to ethylene receptor ETR1 amino-terminal signaling independent of CTR1. | Plant physiology | 40 | 22566492 |
| 2023 | Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas. | Nature communications | 38 | 36690618 |
| 2019 | POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. | EBioMedicine | 38 | 30745168 |
| 2012 | Uptake of copper from plasma proteins in cells where expression of CTR1 has been modulated. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine | 38 | 22354499 |
| 2019 | Copper-zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine | 37 | 31292775 |
| 2007 | Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. | Proceedings of the National Academy of Sciences of the United States of America | 37 | 17620605 |
| 2021 | Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. | Nature communications | 36 | 34373451 |
| 2012 | Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons. | Biochemical pharmacology | 36 | 23123662 |
| 2021 | An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. | Cell chemical biology | 35 | 34672954 |
| 2017 | Host Cell Copper Transporters CTR1 and ATP7A are important for Influenza A virus replication. | Virology journal | 35 | 28115001 |
| 2006 | Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization. | American journal of physiology. Regulatory, integrative and comparative physiology | 34 | 16741141 |
| 2022 | The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS. | Frontiers in molecular biosciences | 32 | 36518851 |
| 2018 | The Cu(II) affinity of the N-terminus of human copper transporter CTR1: Comparison of human and mouse sequences. | Journal of inorganic biochemistry | 32 | 29402466 |
| 2011 | Protein kinase domain of CTR1 from Arabidopsis thaliana promotes ethylene receptor cross talk. | Journal of molecular biology | 32 | 22155294 |
| 2010 | Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue. | Molecular pain | 31 | 20836889 |
| 2015 | EPR spectroscopy shows that the blood carrier protein, human serum albumin, closely interacts with the N-terminal domain of the copper transporter, Ctr1. | The journal of physical chemistry. B | 30 | 25794362 |
| 2015 | The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). | Metallomics : integrated biometal science | 30 | 26205368 |
| 2017 | Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2. | The Journal of biological chemistry | 29 | 28507097 |
| 2022 | Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. | Science advances | 28 | 35559673 |
| 2022 | Glucose restriction induces ROS-AMPK-mediated CTR1 expression and increases cisplatin efficiency in NSCLC. | Cancer letters | 28 | 35716782 |
| 2020 | Uncertainty of EIN2Ser645/Ser924 Inactivation by CTR1-Mediated Phosphorylation Reveals the Complexity of Ethylene Signaling. | Plant communications | 28 | 33367241 |
| 2017 | The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. | Human molecular genetics | 28 | 28973536 |
| 2024 | SP1/CTR1-mediated oxidative stress-induced cuproptosis in intervertebral disc degeneration. | BioFactors (Oxford, England) | 26 | 38599595 |
| 2014 | Salinity-dependent copper accumulation in the guppy Poecilia vivipara is associated with CTR1 and ATP7B transcriptional regulation. | Aquatic toxicology (Amsterdam, Netherlands) | 26 | 24813262 |
| 2018 | Carnosine modulates the Sp1-Slc31a1/Ctr1 copper-sensing system and influences copper homeostasis in murine CNS-derived cells. | American journal of physiology. Cell physiology | 25 | 30485136 |
| 2013 | Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells. | Toxicology letters | 25 | 24316150 |
| 1999 | Evidence for (Mac1p)2.DNA ternary complex formation in Mac1p-dependent transactivation at the CTR1 promoter. | The Journal of biological chemistry | 25 | 9867833 |
| 2012 | Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity. | Toxicology and applied pharmacology | 24 | 22465424 |
| 2001 | ctr1, a gene involved in a signal transduction pathway of the gliding motility in the cyanobacterium Synechocystis sp. PCC 6803. | FEBS letters | 24 | 11248232 |
| 2022 | The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. | eLife | 23 | 36373674 |
| 2019 | Isoform-specific GSK3A activity is negatively correlated with human sperm motility. | Molecular human reproduction | 23 | 30824926 |
| 2013 | A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 23 | 23879689 |
| 2007 | Effect of copper and role of the copper transporters ATP7A and CTR1 in intracellular accumulation of cisplatin. | Anticancer research | 23 | 17695505 |
| 2022 | Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. | The EMBO journal | 22 | 35993436 |
| 2019 | CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences. | Cells | 22 | 30959888 |
| 2009 | Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry | 21 | 19856191 |
| 2019 | Nitric oxide increases biofilm formation in Saccharomyces cerevisiae by activating the transcriptional factor Mac1p and thereby regulating the transmembrane protein Ctr1. | Biotechnology for biofuels | 19 | 30809273 |
| 2014 | Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4. | Biochemical pharmacology | 19 | 24967972 |
| 2015 | Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain. | Bioorganic & medicinal chemistry | 18 | 25865132 |
| 2004 | Co-expression of an ethylene receptor gene, ERS1, and ethylene signaling regulator gene, CTR1, in Delphinium during abscission of florets. | Plant physiology and biochemistry : PPB | 18 | 15474381 |
| 2021 | Tetrahedral Framework Nucleic Acid Delivered RNA Therapeutics Significantly Attenuate Pancreatic Cancer Progression via Inhibition of CTR1-Dependent Copper Absorption. | ACS applied materials & interfaces | 17 | 34549583 |
| 2019 | Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis. | PloS one | 17 | 31002737 |