Affinage

CATSPERB

Cation channel sperm-associated auxiliary subunit beta · UniProt Q9H7T0

Length
1116 aa
Mass
126.9 kDa
Annotated
2026-04-28
11 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CATSPERB is a component of the CatSper ion channel complex in sperm, localizing to the principal piece of the flagellum, where its presence depends on the pore-forming subunit CATSPER1 (PMID:19516020). In CATSPER1-deficient sperm, CATSPERB protein is lost, indicating that CATSPER1 is required for the trafficking and/or assembly of CATSPERB into the complex (PMID:19516020).

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2009 Medium

    Establishing that CATSPERB is a CatSper complex subunit whose principal-piece localization requires CATSPER1 answered whether auxiliary proteins depend on the pore-forming subunit for their assembly into the channel complex.

    Evidence Co-immunoprecipitation, immunofluorescence, and analysis of CATSPER1-null mouse sperm

    PMID:19516020

    Open questions at the time
    • Single-lab study; awaits independent confirmation
    • Direct biochemical role of CATSPERB within the CatSper complex (e.g., ion gating, stability) is unknown
    • No CATSPERB-null model to define its requirement for channel function or male fertility

Open questions

Synthesis pass · forward-looking unresolved questions
  • The specific functional contribution of CATSPERB to CatSper channel activity, sperm hyperactivation, and fertilization remains undefined.
  • No loss-of-function studies targeting CATSPERB itself
  • No structural or electrophysiological data for CATSPERB within the CatSper complex
  • Potential roles in sperm capacitation or chemotaxis have not been tested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Pathway
R-HSA-1474165 Reproduction 1
Partners
CATSPER1
Complex memberships
CatSper channel complex

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 CATSPERB is a component of the CATSPER protein complex in sperm, and its localization in the sperm principal piece depends on CATSPER1; in CATSPER1-deficient sperm, CATSPERB protein is lost, indicating CATSPER1 is required for the trafficking and/or assembly of CATSPERB within the complex. Co-immunoprecipitation, immunofluorescence localization, and analysis of CATSPER1-deficient sperm Biology of reproduction Medium 19516020

Source papers

Stage 0 corpus · 11 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biology of reproduction 99 19516020
2010 Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. The Journal of clinical endocrinology and metabolism 65 20164292
2020 Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. Journal of the European Academy of Dermatology and Venereology : JEADV 24 32031713
2019 Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm. Iranian journal of medical sciences 17 30936599
2020 Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers. Asian Pacific journal of cancer prevention : APJCP 12 33247676
2022 Identification of Circular RNAs of Testis and Caput Epididymis and Prediction of Their Potential Functional Roles in Donkeys. Genes 8 36672807
2021 Novel Tumor-Specific Antigens for Immunotherapy Identified From Multi-omics Profiling in Thymic Carcinomas. Frontiers in immunology 6 34867976
2017 Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS). Hereditary cancer in clinical practice 6 29213343
2016 [Mutation screening for the causative gene in a four-generation Chinese pedigree with progressive cardiac conduction defect]. Zhonghua xin xue guan bing za zhi 3 27220576
2024 Prochloraz induced alterations in the expression of mRNA in the reproductive system of male offspring mice. PeerJ 1 39210919
2014 Relationship between CATSPERB, NR5A2 gene polymorphisms and Peak Bone Mineral Density in College Students in China. Iranian journal of public health 1 25927035