- Length
- 584 aa
- Mass
- 65.0 kDa
- Annotated
- 2026-06-14
50 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 50 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2014 | The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells. | Immunity | 404 | 24703779 |
| 2012 | The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. | The Journal of biological chemistry | 147 | 22846996 |
| 2015 | Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. | Journal of immunology (Baltimore, Md. : 1950) | 128 | 25637025 |
| 2013 | Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells. | Journal of immunology (Baltimore, Md. : 1950) | 128 | 23833237 |
| 2023 | BTN3A3 evasion promotes the zoonotic potential of influenza A viruses. | Nature | 79 | 37380775 |
| 2021 | BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells. | Cell reports | 77 | 34260935 |
| 2016 | Altered expression of Butyrophilin (BTN) and BTN-like (BTNL) genes in intestinal inflammation and colon cancer. | Immunity, inflammation and disease | 72 | 27957327 |
| 2011 | Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. | European journal of immunology | 70 | 21918970 |
| 2024 | Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome. | Genome medicine | 66 | 38898508 |
| 2019 | LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3. | Cell research | 61 | 30858559 |
| 2010 | An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. | Nucleic acids research | 51 | 20421211 |
| 2010 | Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity. | Journal of leukocyte biology | 50 | 20610803 |
| 2016 | Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis. | PloS one | 42 | 27898717 |
| 2023 | A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing. | Nature communications | 40 | 37993425 |
| 2012 | Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. | PloS one | 38 | 22970192 |
| 2010 | Risk of ovarian cancer and inherited variants in relapse-associated genes. | PloS one | 35 | 20111712 |
| 2012 | Incidence of apoptosis and transcript abundance in bovine follicular cells is associated with the quality of the enclosed oocyte. | Theriogenology | 31 | 22578626 |
| 2002 | A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane. | Proteomics | 31 | 12124930 |
| 2025 | Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction. | Frontiers in immunology | 27 | 39981232 |
| 2014 | Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination. | Human genetics | 26 | 25098560 |
| 2019 | Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human Vγ2Vδ2 T Cells. | Journal of immunology (Baltimore, Md. : 1950) | 23 | 31227581 |
| 2014 | Epigenetic activation of immune genes in cervical cancer. | Immunology letters | 23 | 25310935 |
| 2017 | Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family. | Immunogenetics | 22 | 28382515 |
| 2024 | Unsynchronized butyrophilin molecules dictate cancer cell evasion of Vγ9Vδ2 T-cell killing. | Cellular & molecular immunology | 21 | 38374404 |
| 2023 | Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders. | Schizophrenia bulletin | 20 | 37418754 |
| 2022 | BTN3A3 inhibits the proliferation, migration and invasion of ovarian cancer cells by regulating ERK1/2 phosphorylation. | Frontiers in oncology | 14 | 36059652 |
| 2018 | The Armadillo (Dasypus novemcinctus): A Witness but Not a Functional Example for the Emergence of the Butyrophilin 3/Vγ9Vδ2 System in Placental Mammals. | Frontiers in immunology | 14 | 29527206 |
| 2015 | Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children. | Immunogenetics | 14 | 26329766 |
| 2023 | Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders. | Human genetics | 11 | 37085628 |
| 2019 | Three Biomarkers Predict Gastric Cancer Patients' Susceptibility To Fluorouracil-based Chemotherapy. | Journal of Cancer | 11 | 31281472 |
| 2023 | Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population. | The Journal of investigative dermatology | 10 | 36804966 |
| 2015 | Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection. | Genes and immunity | 10 | 25928882 |
| 2025 | Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation. | Immunity | 9 | 40334665 |
| 2023 | BTN3A3 inhibits clear cell renal cell carcinoma progression by regulating the ROS/MAPK pathway via interacting with RPS3A. | Cellular signalling | 7 | 37806541 |
| 2024 | A Ménage à trois: NLRC5, immunity, and metabolism. | Frontiers in immunology | 5 | 39035010 |
| 2023 | Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells. | Research square | 4 | 36824912 |
| 2024 | Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population. | Clinical and experimental dermatology | 3 | 38651209 |
| 2023 | Use of exosome transcriptome-based analysis to identify novel biomarkers in patients with locally advanced esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy. | Annals of translational medicine | 3 | 36923096 |
| 2022 | Integrated Analysis of Microarray Studies to Identify Novel Diagnostic Markers in Bladder Pain Syndrome/Interstitial Cystitis with Hunner Lesion. | International journal of general medicine | 3 | 35342305 |
| 2019 | Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators. | Immunogenetics | 3 | 31384962 |
| 2026 | Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis. | Science immunology | 2 | 41650251 |
| 2025 | PSMB4: a potential biomarker and therapeutic target for depression, perspective from integration analysis of depression GWAS data and human plasma proteome. | Translational psychiatry | 2 | 39979251 |
| 2023 | Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes. | Scientific reports | 2 | 37903831 |
| 2025 | γ9δ2 T cells detect mevalonate diphosphate via BTN3A3. | Cellular and molecular life sciences : CMLS | 1 | 41236636 |
| 2025 | Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus. | Journal of molecular and cellular cardiology plus | 1 | 41377472 |
| 2023 | Integrating GWAS and proteome data to identify novel drug targets for MU. | Scientific reports | 1 | 37369724 |
| 2023 | The determinants associated with zoonotic potential of influenza A viruses: BTN3A3 evasion mediated by residue mutation in the nucleoprotein. | MedComm | 1 | 38045831 |
| 2026 | Cell stress activates γ9δ2 T cells via endogenous phosphoantigens and butyrophilin complex dynamics. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 0 | 41576851 |
| 2026 | The BTN3A3-TOMM22 axis preserves mitochondrial homeostasis to facilitate HCC stemness and drug resistance. | Cancer letters | 0 | 42069175 |
| 2024 | Using gene and gene-set association tests to identify lethal prostate cancer genes. | Prostate cancer and prostatic diseases | 0 | 39154125 |
Missed literature
Know a paper Affinage missed for BTN3A3? Flag it for the maintainers and the community.
No submissions yet.