- Length
- 726 aa
- Mass
- 79.5 kDa
- Annotated
- 2026-06-13
56 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 56 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2008 | The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. | Molecular cell | 304 | 18406326 |
| 2011 | Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. | Proceedings of the National Academy of Sciences of the United States of America | 197 | 21536911 |
| 2020 | lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. | Nature cell biology | 121 | 32895492 |
| 2004 | Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis. | Gene expression patterns : GEP | 99 | 15261828 |
| 2011 | Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3. | Molecular and cellular biology | 93 | 21555453 |
| 2016 | BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. | PloS one | 69 | 27008626 |
| 1997 | Characterization of transcription organization and analysis of unique expression patterns of an alkyl hydroperoxide reductase C gene (ahpC) and the peroxide regulator operon ahpF-oxyR-orfX from Xanthomonas campestris pv. phaseoli. | Journal of bacteriology | 63 | 9190811 |
| 2012 | Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfX, the gene containing the staphylococcal chromosome Cassette mec (SCCmec) insertion site. | The Journal of biological chemistry | 55 | 23150671 |
| 2018 | The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators. | The Journal of biological chemistry | 53 | 29567837 |
| 2016 | Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. | Journal of virology | 48 | 27170748 |
| 2005 | PCR for the identification of methicillin-resistant Staphylococcus aureus (MRSA) strains using a single primer pair specific for SCCmec elements and the neighbouring chromosome-borne orfX. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases | 42 | 16153258 |
| 2017 | BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis. | Scientific reports | 37 | 28733670 |
| 2000 | An accessory open reading frame (orf-x) of jaagsiekte sheep retrovirus is conserved between different virus isolates. | Virus research | 36 | 10653922 |
| 1997 | Isolation and analysis of the Xanthomonas alkyl hydroperoxide reductase gene and the peroxide sensor regulator genes ahpC and ahpF-oxyR-orfX. | Journal of bacteriology | 34 | 9190810 |
| 2017 | OrfX, a Nucleomodulin Required for Listeria monocytogenes Virulence. | mBio | 33 | 29089430 |
| 2021 | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. | Structure (London, England : 1993) | 32 | 33592170 |
| 1997 | Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. | Gene | 32 | 9373153 |
| 2007 | In vivo tumorigenesis by Jaagsiekte sheep retrovirus (JSRV) requires Y590 in Env TM, but not full-length orfX open reading frame. | Virology | 31 | 17610928 |
| 2021 | Targeting BET Proteins BRD2 and BRD3 in Combination with PI3K-AKT Inhibition as a Therapeutic Strategy for Ovarian Clear Cell Carcinoma. | Molecular cancer therapeutics | 29 | 33509905 |
| 2014 | Rapid and simple detection of methicillin-resistance Staphylococcus aureus by orfX loop-mediated isothermal amplification assay. | BMC biotechnology | 27 | 24456841 |
| 2022 | BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation. | Cellular and molecular life sciences : CMLS | 23 | 35665862 |
| 2017 | Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. | Scientific reports | 23 | 28045112 |
| 2023 | Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. | Science advances | 20 | 37043564 |
| 2019 | Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression. | Journal of orthopaedic surgery and research | 19 | 30786900 |
| 2021 | The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental Factors and Gene Interactions via Mobile Genetic Elements. | Frontiers in microbiology | 18 | 33716993 |
| 2021 | Skin adnexal carcinoma with BRD3-NUTM2B fusion. | Journal of cutaneous pathology | 18 | 34296453 |
| 2017 | Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster. | FEBS letters | 18 | 29067689 |
| 2009 | Single-nucleotide polymorphism in the SCCmec-orfX junction distinguishes between livestock-associated MRSA CC398 and human epidemic MRSA strains. | Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin | 14 | 20003904 |
| 2019 | Looking for the X Factor in Bacterial Pathogenesis: Association of orfX-p47 Gene Clusters with Toxin Genes in Clostridial and Non-Clostridial Bacterial Species. | Toxins | 12 | 31906154 |
| 2012 | Three calcium-sensitive genes, fus, brd3 and wdr5, are highly expressed in neural and renal territories during amphibian development. | Biochimica et biophysica acta | 11 | 23287019 |
| 2023 | Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines. | European journal of medicinal chemistry | 10 | 37084596 |
| 2017 | BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. | PloS one | 10 | 29240787 |
| 2023 | Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1. | FEBS letters | 9 | 36653893 |
| 2024 | Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer. | Cancer science | 8 | 38494600 |
| 2003 | [Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]. | Ai zheng = Aizheng = Chinese journal of cancer | 8 | 12600283 |
| 2022 | Long noncoding RNA NEAT1 decreases polycystic ovary syndrome progression via the modulation of the microRNA-324-3p and BRD3 axis. | Cell biology international | 7 | 36040750 |
| 2024 | mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain. | Angewandte Chemie (International ed. in English) | 6 | 38899853 |
| 2023 | BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts. | Biomedicines | 6 | 38137409 |
| 1998 | Analysis of the hepatitis B virus precore and ORF-X sequences in patients with antibody to hepatitis B e antigen with and without normal ALT levels. | Journal of medical virology | 6 | 9829632 |
| 1998 | Identification of a restriction fragment length polymorphism associated with a deletion that maps in a transcriptionally active open-reading frame, orfX, in Mycobacterium tuberculosis Erdman. | Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease | 5 | 10645444 |
| 2024 | BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing. | NAR genomics and bioinformatics | 4 | 38226395 |
| 2024 | Achieving theranostic probes targeting BRD3/BRD4 for imaging and therapy of tumor. | European journal of medicinal chemistry | 4 | 39681044 |
| 2021 | BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall. | Diagnostic cytopathology | 4 | 34672128 |
| 2025 | A non-canonical immunometabolic function of BRD3 during sepsis. | Developmental cell | 3 | 41118770 |
| 2024 | Ku70 targets BRD3-MYC/Cyclin D1 axis to drive hepatocellular carcinoma progression. | Experimental cell research | 3 | 39743013 |
| 2023 | Case report of a pan-cytokeratin negative NUT midline carcinoma of pulmonary origin, a BRD3-NUT variant: Challenges in cytomorphologic presentation. | Diagnostic cytopathology | 3 | 37021735 |
| 2021 | Epigenetic readers and lung cancer: the rs2427964C>T variant of the bromodomain and extraterminal domain gene BRD3 is associated with poorer survival outcome in NSCLC. | Molecular oncology | 3 | 34605158 |
| 2025 | Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer. | Non-coding RNA | 2 | 40407591 |
| 2025 | Histone H3 acetylation reverses radioresistance in breast cancers through BRD3-mediated inhibition of RAD51 and inducing ferroptosis. | Free radical biology & medicine | 2 | 41046945 |
| 2025 | Hybrid AI/physics pipeline for miniprotein binder prioritization: application to the BRD3 ET domain. | Chemical communications (Cambridge, England) | 2 | 41211640 |
| 2024 | OsFAD1-OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice. | Journal of integrative plant biology | 2 | 39279451 |
| 2025 | Rep_3 plasmids found in Acinetobacter species that include orfX also harbour dif modules. | Plasmid | 1 | 40280505 |
| 2025 | BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR. | Cell reports | 1 | 41134669 |
| 2016 | [Brd3 promotes IL-6 production via enhancing acetylase CBP recruitment and histone 3 acetylation within IL6 promoter]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | 1 | 27667451 |
| 2025 | BRD3 PROTAC degrader targets H3K18ac to alleviate retinal microglia-driven uveitis. | iScience | 0 | 41585484 |
| 2020 | Author Correction: Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. | Scientific reports | 0 | 33262417 |
Missed literature
Know a paper Affinage missed for BRD3? Flag it for the maintainers and the community.
No submissions yet.