{"gene":"BRD3","run_date":"2026-06-13T19:06:35","timeline":{"discoveries":[],"current_model":"Parse failed"},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q15059","full_name":"Bromodomain-containing protein 3","aliases":["RING3-like protein"],"length_aa":726,"mass_kda":79.5,"function":"Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity)","subcellular_location":"Nucleus; Chromosome","url":"https://www.uniprot.org/uniprotkb/Q15059/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/BRD3","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":true,"resolved_as":"","ensg_id":"ENSG00000169925","cell_line_id":"CID001134","localizations":[{"compartment":"nucleoplasm","grade":3}],"interactors":[],"url":"https://opencell.sf.czbiohub.org/target/CID001134","total_profiled":1310},"omim":[{"mim_id":"618829","title":"NABAIS SA-DE VRIES SYNDROME, TYPE 2; NSDVS2","url":"https://www.omim.org/entry/618829"},{"mim_id":"618828","title":"NABAIS SA-DE VRIES SYNDROME, TYPE 1; NSDVS1","url":"https://www.omim.org/entry/618828"},{"mim_id":"608749","title":"BROMODOMAIN-CONTAINING PROTEIN 4; BRD4","url":"https://www.omim.org/entry/608749"},{"mim_id":"602650","title":"SPECKLE-TYPE BTB/POZ PROTEIN; SPOP","url":"https://www.omim.org/entry/602650"},{"mim_id":"601541","title":"BROMODOMAIN-CONTAINING PROTEIN 3; BRD3","url":"https://www.omim.org/entry/601541"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Supported","locations":[{"location":"Nucleoplasm","reliability":"Supported"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/BRD3"},"hgnc":{"alias_symbol":["RING3L","ORFX","KIAA0043","FSHRG2"],"prev_symbol":[]},"alphafold":{"accession":"Q15059","domains":[{"cath_id":"1.20.920.10","chopping":"36-137","consensus_level":"high","plddt":96.4829,"start":36,"end":137},{"cath_id":"1.20.920.10","chopping":"309-412","consensus_level":"high","plddt":96.5901,"start":309,"end":412},{"cath_id":"1.20.1270.220","chopping":"573-636","consensus_level":"high","plddt":88.4605,"start":573,"end":636}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q15059","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q15059-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q15059-F1-predicted_aligned_error_v6.png","plddt_mean":66.88},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=BRD3","jax_strain_url":"https://www.jax.org/strain/search?query=BRD3"},"sequence":{"accession":"Q15059","fasta_url":"https://rest.uniprot.org/uniprotkb/Q15059.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q15059/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q15059"}},"corpus_meta":[{"pmid":"18406326","id":"PMC_18406326","title":"The 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