Affinage

BMS1

Ribosome biogenesis protein BMS1 homolog · UniProt Q14692

Length
1282 aa
Mass
145.8 kDa
Annotated
2026-06-09
83 papers in source corpus 13 papers cited in narrative 13 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BMS1 is an essential nucleolar GTPase that drives early small ribosomal subunit (40S) biogenesis by acting as a GTP-regulated molecular switch within the 90S pre-ribosome/SSU processome (PMID:16307926, PMID:27419870). In its GTP-bound state BMS1 binds RCL1 and U3 snoRNA with thermodynamic coupling to form a discrete ribonucleoprotein subcomplex, and its own C-terminal domain functions as an intramolecular GTPase-activating domain while RCL1 promotes GDP/GTP exchange, so that nucleotide state governs assembly of the module (PMID:16307926, PMID:16376378). BMS1 thereby delivers and stabilizes RCL1: an RCL1-interacting domain conserved between zebrafish and human is required for RCL1 nucleolar entry and protects it from ubiquitin-proteasome degradation, and RCL1 overexpression partially rescues 18S processing and proliferation defects of BMS1-deficient cells (PMID:37451810). The module is loaded co-transcriptionally downstream of the tUTP and U3/UTP-B subcomplexes (PMID:21724601, PMID:19332556) and is positioned near the A1 cleavage site and the Utp24 endonuclease in the 90S particle, where it directs pre-18S rRNA processing and folding (PMID:27419870, PMID:28967883). BMS1 is released from the particle during the ATP-dependent, Dhr1-catalyzed 90S-to-pre-40S transition that accompanies central pseudoknot formation (PMID:36263816, PMID:33306676). Beyond ribosome assembly, BMS1 physically interacts with the replication-fork-barrier protein Ttf1 and uses its GTPase activity to displace Ttf1 from rDNA, coordinating rDNA transcription with replication (PMID:34791311). A heterozygous p.R930H mutation in BMS1 causes human aplasia cutis congenita, with delayed 18S rRNA maturation and reduced proliferation through a p21-mediated G1/S delay (PMID:23785305).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2005 High

    Established the core biochemical logic of BMS1: how a GTPase delivers a partner protein to pre-ribosomes, defining it as a regulated molecular switch rather than a passive scaffold.

    Evidence In vitro thermodynamic binding, GAP activity assays, and yeast mutant expression showing GTP-coupled Bms1–Rcl1–U3 binding and an intramolecular GAP domain

    PMID:16307926 PMID:16376378

    Open questions at the time
    • Did not resolve where on the pre-ribosome the module docks
    • Physiological trigger for GTP hydrolysis in vivo not defined
  2. 2009 Medium

    Placed the BMS1/RCL1 module in the human SSU processome and showed BMS1 expression level tunes subunit stoichiometry, extending the yeast switch model to human assembly and quantitative output.

    Evidence Sucrose gradients and reciprocal co-IP in human cells; doxycycline-regulated BMS1 with polysome profiling in yeast

    PMID:19178690 PMID:19332556

    Open questions at the time
    • Causal mechanism linking BMS1 dose to 60S:40S ratio not dissected
    • Did not define order of module recruitment relative to other factors
  3. 2011 Medium

    Ordered BMS1 within the assembly hierarchy, showing it loads downstream of tUTP and U3/UTP-B and is itself required to recruit later factors.

    Evidence Conditional depletion, co-IP, and co-transcriptional ChIP of nascent pre-rRNA in yeast

    PMID:21724601

    Open questions at the time
    • Identity of all BMS1-dependent downstream factors incomplete
    • Single-lab epistasis
  4. 2012 Medium

    Demonstrated that BMS1 GTPase function has organ-level developmental consequences in vertebrates, linking ribosome biogenesis to proliferation of specific tissues.

    Evidence Forward genetic screen of a GTPase-motif allele (L152Q) with in situ hybridization, pH3 and TUNEL in zebrafish

    PMID:23021545

    Open questions at the time
    • Why digestive organs are selectively sensitive not explained
    • Did not connect phenotype to a molecular processing defect
  5. 2013 High

    Connected BMS1 loss-of-function to a human Mendelian disease and a cell-cycle mechanism, showing impaired 18S maturation drives p21-mediated arrest.

    Evidence Linkage, exome sequencing, pre-rRNA processing and proliferation assays in ACC patient fibroblasts carrying p.R930H

    PMID:23785305

    Open questions at the time
    • How a single missense allele produces dominant disease not resolved
    • Tissue specificity of ACC versus broad ribosome requirement unexplained
  6. 2017 High

    Provided the structural basis for BMS1 function by placing it atomically within the 90S particle near the A1 site and Utp24 endonuclease.

    Evidence Cryo-EM of the Chaetomium thermophilum 90S at subnanometer and 3.2-Å resolution with module identification and atomic model building

    PMID:27419870 PMID:28967883

    Open questions at the time
    • Conformational changes upon GTP hydrolysis not captured
    • Dynamics of module release not visualized in these states
  7. 2020 Medium

    Genetically defined BMS1 as acting late in SSU processome disassembly through interactions linking Bud23, U3 snoRNA, and the helicase Dhr1.

    Evidence Comprehensive bud23Δ suppressor screen with structural mapping and co-IP in yeast

    PMID:33306676

    Open questions at the time
    • Direct biochemical effect of suppressor mutations on BMS1 GTPase not measured
    • Temporal coupling of disassembly steps inferred from genetics
  8. 2022 Medium

    Revealed a second BMS1 function beyond assembly: GTPase-driven displacement of Ttf1 to balance rDNA transcription with replication, and established a distinct S-to-G2 arrest phenotype.

    Evidence Bms1–Ttf1 co-IP, zebrafish Ttf1 RFB ChIP-seq, loss-of-function analysis with replication/transcription marker immunostaining

    PMID:34791311

    Open questions at the time
    • Whether Ttf1 displacement is mechanistically separable from ribosome assembly role unclear
    • Single-lab Co-IP for the new interaction
  9. 2022 High

    Pinpointed BMS1 release in the maturation pathway, coupling ATP-dependent U3 release to pre-40S decoding-center formation.

    Evidence In vitro reconstitution of the 90S-to-pre-40S transition with cryo-EM of Dis-D and Dis-E intermediates

    PMID:36263816

    Open questions at the time
    • Whether BMS1 GTP hydrolysis triggers or follows release not resolved
    • Energetics of factor release not quantified
  10. 2024 High

    Defined the molecular basis of the BMS1–RCL1 partnership, showing BMS1 stabilizes RCL1 against proteasomal degradation and enables its nucleolar entry, and that this axis underlies disease-relevant phenotypes.

    Evidence Co-IP, ubiquitination and proteasome-inhibitor assays, siRNA knockdown with processing assays, and hepatocyte-specific Rcl1 rescue in zebrafish bms1l mutants

    PMID:37451810

    Open questions at the time
    • Ubiquitin ligase targeting free RCL1 not identified
    • Why knockout cannot be rescued by RCL1 while hypomorph can is only partly explained by residual interaction

Open questions

Synthesis pass · forward-looking unresolved questions
  • How BMS1's GTP hydrolysis cycle is temporally triggered in vivo and how its ribosome-assembly and rDNA transcription/replication functions are coordinated within one cell remain unresolved.
  • No structure captures the GTP-to-GDP transition coupled to module release
  • Mechanistic relationship between the Ttf1-displacement role and the pre-ribosome role undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 4 GO:0140098 catalytic activity, acting on RNA 3 GO:0003723 RNA binding 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005730 nucleolus 2
Pathway
R-HSA-8953854 Metabolism of RNA 4 R-HSA-1640170 Cell Cycle 2
Partners
RCL1TTF1U3 SNORNA
Complex memberships
90S pre-ribosome / SSU processomeBMS1–RCL1–U3 snoRNP subcomplex

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 Bms1 is an essential GTPase required for 40S ribosomal subunit biogenesis that functions as a GTP-regulated switch to deliver Rcl1 to preribosomes; thermodynamic coupling was demonstrated between Bms1 binding to GTP, Rcl1, and U3 snoRNA, and the C-terminal domain of Bms1 acts as an intramolecular GTPase-activating protein (GAP). Rcl1 binding to preribosomes is severely limited when a Bms1 mutant defective for Rcl1 binding is expressed. In vitro binding assays (thermodynamic analysis), yeast genetics (mutant expression), GAP activity assay, U3 snoRNA binding assays Molecular cell High 16307926
2005 Bms1, Rcl1, and U3 snoRNA form a stable ribonucleoprotein subcomplex in a GTP-dependent manner; Rcl1 promotes GDP/GTP exchange on Bms1, analogous to ribosome-promoted nucleotide exchange in translation elongation factor EF-G. GDP eliminates the thermodynamic coupling between Rcl1, U3 snoRNA, and GTP binding to Bms1. Quantitative thermodynamic binding analysis (ITC/fluorescence), GTP/GDP binding assays, subcomplex reconstitution Journal of molecular biology High 16376378
2011 Loading of Bms1 onto pre-rRNA occurs independently of the Rrp5/UTP-C assembly branch and downstream of the tUTP and U3/UTP-B subcomplexes. Bms1 is required for the recruitment of a subset of proteins to nascent pre-ribosomes, placing it as a secondary assembly factor in the 90S pre-ribosome pathway. Yeast genetics (conditional depletion), co-immunoprecipitation, chromatin immunoprecipitation of nascent pre-rRNA (co-transcriptional assembly assay) Nucleic acids research Medium 21724601
2013 A heterozygous p.R930H missense mutation in BMS1 causes aplasia cutis congenita (ACC) and is associated with delayed 18S rRNA maturation (consistent with BMS1's role in small ribosomal subunit pre-rRNA processing). ACC fibroblasts carrying this mutation show reduced cell proliferation due to a p21-mediated G1/S phase transition delay, linking BMS1 function to cell cycle regulation. Genome-wide linkage analysis, exome sequencing, pre-rRNA processing assays, cell proliferation assays, transcriptomic and proteomic analyses of patient fibroblasts PLoS genetics High 23785305
2009 Tuning BMS1 transcript levels in yeast perturbs the ratio of 60S to 40S ribosomal subunits (from ~1:1 to ~2:1), demonstrating that BMS1 expression level directly controls ribosomal subunit stoichiometry and that altered subunit ratios affect recombinant protein yields. Doxycycline-regulated BMS1 expression, polysome profiling, flow microcalorimetry Microbial cell factories Medium 19178690
2009 The human SSU processome contains a BMS1/RCL1 subcomplex that is recruited to the pre-rRNA as a discrete module; this subcomplex is absent from a novel 50S U3 snoRNP assembly intermediate that accumulates when pre-rRNA transcription is blocked or tUTP proteins are depleted. Sucrose gradient sedimentation, co-immunoprecipitation, siRNA knockdown, Northern blot analysis of pre-rRNA Molecular and cellular biology Medium 19332556
2016 Cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome identifies the Bms1-Rcl1 module as one of five distinct submodules organized around the 5'-ETS and partially folded 18S rRNA, revealing how Bms1-Rcl1 is spatially positioned within the early pre-ribosomal particle. Cryo-EM structural determination of 90S pre-ribosome Cell High 27419870
2017 3.2-Å-resolution cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome allowed atomic model building for Bms1, revealing its precise structural contacts within the 90S particle and its positioning near the unprocessed A1 cleavage site and the Utp24 endonuclease. Cryo-EM at 3.2-Å resolution, atomic model building Nature structural & molecular biology High 28967883
2012 In zebrafish, the Bms1-like protein (Bms1l) carrying an L152Q substitution in a GTPase motif causes selective hypoplasia of the liver, exocrine pancreas, and intestine due to impaired hepatoblast proliferation (not apoptosis), demonstrating that GTPase activity of Bms1l is required for digestive organ development in vertebrates. Forward genetic screen, whole-mount in situ hybridization, phospho-histone H3 immunostaining, TUNEL assay in zebrafish mutants Journal of genetics and genomics Medium 23021545
2022 Bms1 (nucleolar GTPase) displaces Ttf1 from replication-fork-barrier (RFB) sites on rDNA using its GTPase activity; Bms1 physically interacts with Ttf1 in addition to Rcl1. Loss of Bms1l in zebrafish upregulates rDNA transcription, causes replication-fork stalling, and arrests the cell cycle at S-to-G2 transition, while G1-to-S transition remains active. Co-immunoprecipitation (Bms1–Ttf1 interaction), ChIP-seq (zebrafish Ttf1 RFB sites), zebrafish loss-of-function analysis, immunostaining for replication/transcription markers (Chk2, Rad51, p53, PCNA, Fen1, Rpa2, Ttf1, Ubf, tif-IA, taf1b) Journal of molecular cell biology Medium 34791311
2022 In vitro reconstitution of the 90S-to-pre-40S transition showed that ATP-dependent U3 snoRNA release (catalyzed by helicase Dhr1) leads to loss of all residual 90S factors including GTPase Bms1, and this process is coupled to formation of the central pseudoknot of the small subunit decoding center. In vitro reconstitution of pre-40S maturation, cryo-EM of successive pre-40S intermediates (Dis-D and Dis-E) Nucleic acids research High 36263816
2020 Genetic suppressor screen of bud23Δ in yeast identified mutations in BMS1 (among DHR1, IMP4, UTP2/NOP14, and RPS28A) that rescue growth, placing Bms1 in a physical interaction network linking Bud23's binding site to the U3 snoRNA. The suppressing mutations weaken protein-protein and protein-RNA interactions, and Bms1 acts late in SSU Processome disassembly. Comprehensive genetic suppressor screen, mapping of suppressing mutations to structural models, co-immunoprecipitation PLoS genetics Medium 33306676
2024 An RCL1-interacting domain in BMS1 (conserved between zebrafish and humans) is required for RCL1 protein stability and nucleolar entry: when this interaction is disrupted, RCL1 is degraded via the ubiquitination-proteasome pathway. Overexpression of RCL1 in BMS1-knockdown cells partially rescues 18S rRNA processing defects and cell proliferation. Hepatocyte-specific overexpression of Rcl1 rescues liver development in a bms1l hypomorphic (but not knockout) zebrafish mutant, because residual Bms1l–Rcl1 interaction enables nucleolar entry of Rcl1. Co-immunoprecipitation (BMS1–RCL1), ubiquitination assay, proteasome inhibitor experiments, siRNA knockdown of BMS1, pre-rRNA processing assays, zebrafish hepatocyte-specific rescue experiments Journal of molecular cell biology High 37451810

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome. Cell 181 27419870
2022 Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages. Journal of experimental & clinical cancer research : CR 176 34980222
1994 Dissemination among staphylococci of DNA sequences associated with methicillin resistance. Antimicrobial agents and chemotherapy 111 7911288
2017 3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage. Nature structural & molecular biology 90 28967883
2007 Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology 86 17217969
1996 Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus. Journal of bacteriology 82 8808937
2005 An essential GTPase promotes assembly of preribosomal RNA processing complexes. Molecular cell 69 16307926
2022 Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice. Molecular cancer research : MCR 67 35190830
2019 Genetic architecture of laterality defects revealed by whole exome sequencing. European journal of human genetics : EJHG 61 30622330
2009 A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4. Molecular and cellular biology 59 19332556
2024 Metabolism/Immunity Dual-Regulation Thermogels Potentiating Immunotherapy of Glioblastoma Through Lactate-Excretion Inhibition and PD-1/PD-L1 Blockade. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 56 38460167
2011 Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes. Nucleic acids research 47 21724601
2009 Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield. Microbial cell factories 47 19178690
2000 Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q. Human molecular genetics 47 10942432
1995 Hematopoietic-promoting activity of the murine stromal cell line MS-5 is not related to the expression of the major hematopoietic cytokines. Journal of cellular physiology 44 7706374
2021 Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy via a thermosensitive liposome system to stimulate tumor-specific immunological response. Nanoscale 43 34477780
2021 Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells. Journal of nanobiotechnology 42 34488792
2013 BMS1 is mutated in aplasia cutis congenita. PLoS genetics 42 23785305
2002 Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction. Journal of andrology 36 11780926
2006 A single cyanobacterial ribotype is associated with both red and black bands on diseased corals from Palau. Diseases of aquatic organisms 35 16703773
2021 Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis. Bioactive materials 34 34466740
2005 GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. Journal of molecular biology 34 16376378
2024 Nanoparticle-mediated blockade of CXCL12/CXCR4 signaling enhances glioblastoma immunotherapy: Monitoring early responses with MRI radiomics. Acta biomaterialia 30 38360292
2023 Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication. Journal of controlled release : official journal of the Controlled Release Society 29 37068523
2012 Ribosome biogenesis factor Bms1-like is essential for liver development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao 29 23021545
2022 Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor. Small (Weinheim an der Bergstrasse, Germany) 28 36366925
2023 LW-213 induces immunogenic tumor cell death via ER stress mediated by lysosomal TRPML1. Cancer letters 24 37806516
2022 Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia. Scientific reports 24 35859008
2014 Full-scale biological treatment of tannery wastewater using the novel microbial consortium BM-S-1. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 24 24279627
2023 Breaking Tumor Immunosuppressive Network by Regulating Multiple Nodes with Triadic Drug Delivery Nanoparticles. ACS nano 23 37690028
2020 Inhibition of programmed death-1 decreases neointimal hyperplasia after patch angioplasty. Journal of biomedical materials research. Part B, Applied biomaterials 22 32770622
2017 Malignancy in Pheochromocytoma or Paraganglioma: Integrative Analysis of 176 Cases in TCGA. Endocrine pathology 22 28386672
2021 Immune checkpoint programmed death-1 mediates abdominal aortic aneurysm and pseudoaneurysm progression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 21 34339918
2019 Metagenomic analysis of relationships between the denitrification process and carbon metabolism in a bioaugmented full-scale tannery wastewater treatment plant. World journal of microbiology & biotechnology 21 31549239
2002 Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms. Genome research 20 11779832
2023 Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment. International journal of nanomedicine 19 37545872
2020 Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae. PLoS genetics 19 33306676
2024 Novel Bifunctional Conjugates Targeting PD-L1/PARP7 as Dual Immunotherapy for Potential Cancer Treatment. Journal of medicinal chemistry 16 38912753
2023 Electroacupuncture Alleviates CFA-Induced Inflammatory Pain via PD-L1/PD-1-SHP-1 Pathway. Molecular neurobiology 15 36753045
2016 Metagenomic insight of nitrogen metabolism in a tannery wastewater treatment plant bioaugmented with the microbial consortium BM-S-1. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 13 27471001
2011 Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines. Experimental cell research 13 21324313
2023 Hollow Cu2MoS4 nanoparticles loaded with immune checkpoint inhibitors reshape the tumor microenvironment to enhance immunotherapy for pancreatic cancer. Acta biomaterialia 12 37890815
2022 Identification of Important Modules and Hub Gene in Chronic Kidney Disease Based on WGCNA. Journal of immunology research 12 35571562
2007 Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals 11 17303626
2022 In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation. Nucleic acids research 10 36263816
2025 A responsive cocktail nano-strategy breaking the immune excluded state enhances immunotherapy for triple negative breast cancer. Nanoscale 9 39810651
2025 Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment. Materials today. Bio 9 39866795
2021 Programmed death-1 mediates venous neointimal hyperplasia in humans and rats. Aging 9 34170847
2025 De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy. Angewandte Chemie (International ed. in English) 8 40285333
2024 Assembling Au8 clusters on surfaces of bifunctional nanoimmunomodulators for synergistically enhanced low dose radiotherapy of metastatic tumor. Journal of nanobiotechnology 8 38183048
2024 Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis. Chemico-biological interactions 8 39084503
2024 Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas. Cancer letters 8 39341452
2023 PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer. Journal of nanobiotechnology 8 38082443
2024 Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways. Veterinary research 7 39075562
2025 Genome-Wide Association Studies and Candidate Genes for Egg Production Traits in Layers from an F2 Crossbred Population Produced Using Two Divergently Selected Chicken Breeds, Russian White and Cornish White. Genes 6 40428405
2024 Fe3O4 Nanoparticles That Modulate the Polarisation of Tumor-Associated Macrophages Synergize with Photothermal Therapy and Immunotherapy (PD-1/PD-L1 Inhibitors) to Enhance Anti-Tumor Therapy. International journal of nanomedicine 6 39050876
2023 Comprehensive Genomic Analysis of Cemento-Ossifying Fibroma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 6 37995913
2022 Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication. Journal of molecular cell biology 6 34791311
2021 Programmed cell death-1/programmed cell death-ligand 1 inhibitors exert antiapoptosis and antiinflammatory activity in lipopolysaccharide stimulated murine alveolar macrophages. Experimental and therapeutic medicine 6 33680122
2021 Genetics animates structure: leveraging genetic interactions to study the dynamics of ribosome biogenesis. Current genetics 6 33844044
2021 A four-in-one pure nanomedicine for synergistic multi-target therapy against breast cancer. Journal of materials chemistry. B 6 34633023
2025 Bioinspired Construction of Cu-Fe Bimetallic Multienzyme Mimetics as Co-Inducers of Cuproptosis and Ferroptosis. Journal of medicinal chemistry 5 40720791
2024 TMPRSS2 is a tumor suppressor and its downregulation promotes antitumor immunity and immunotherapy response in lung adenocarcinoma. Respiratory research 5 38862975
2024 Chimeric peptide-engineered immunostimulant for endoplasmic reticulum targeted photodynamic immunotherapy against metastatic tumor. Journal of controlled release : official journal of the Controlled Release Society 5 39151829
2022 PD-1/PD-L1 inhibition promotes hepatic regeneration in small-for-size liver following extended hepatectomy. Cytokine 5 36054963
2024 Stability and function of RCL1 are dependent on the interaction with BMS1. Journal of molecular cell biology 4 37451810
2019 Identification of genes and pathways in human antigen-presenting cell subsets in response to polio vaccine by bioinformatical analysis. Journal of medical virology 4 31187886
1992 Effects of cryopreservation on the adherent layer of human long-term bone marrow cultures: study of cell phenotypes. Leukemia 4 1375699
2025 The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases. Cancer cell international 3 39825447
2025 PD-1/PD-L1 inhibitor treatment associated with cardiotoxicity regulated by macrophage polarization and SOCS3/JAK/STAT3 signaling pathway. Central-European journal of immunology 3 40620649
2025 Dynamic Monitoring of Chelatable Zinc on Endoplasmic Reticulum During Immunogenic Cell Death by TPPLIM Using a Theranostic Ir(III) Complex. Analytical chemistry 2 40583441
2024 Histone deacetylase inhibitor and PD‑1 blockade synergistically inhibit B‑cell lymphoma progression in mice model by promoting T‑cell infiltration and apoptosis. Oncology reports 2 39129321
2024 Discovery of Daclatasvir as a potential PD-L1 inhibitor from drug repurposing. Bioorganic chemistry 2 39418845
2024 Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection. Frontiers in pharmacology 2 39555101
2025 Molecular Dynamics-Guided Repositioning of FDA-Approved Drugs for PD-L1 Inhibition with In Vitro Anticancer Potential. International journal of molecular sciences 1 40429641
2025 Targeted reduction-responsive nanovehicles for photodynamic therapy-primed immunotherapy in melanoma. Journal of pharmaceutical analysis 1 41492458
2024 Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1. European journal of medicinal chemistry 1 38678826
2011 The effect of the duration of clopidogrel use on hsCRP levels after stenting the target vessel in patients with acute coronary syndrome. Clinical and investigative medicine. Medecine clinique et experimentale 1 21810378
2026 Functionalized Biomaterials in the Investigation of the Effects of Fluid Shear Forces in the Immune Regulation of Cancer Progression and Metastasis. Journal of functional biomaterials 0 41745543
2026 Evaluation of small molecule PD-1/PD-L1 inhibitors in a T cell reporter system. Biochemical pharmacology 0 41802682
2026 Autophagy inhibition enhances PD-1 blockade efficacy in mismatch repair-proficient colorectal cancer. Cancer genetics 0 41875719
2026 Single-cell RNA sequencing dissect the immunological network of immune checkpoint inhibitors-induced myocarditis. Human molecular genetics 0 41934610
2025 Co-treatment of ticagrelor and anti-PD-1 immunotherapy in tumor-associated macrophages reduces pancreatic cancer cell growth and migration through the TGF-β1/Smad2 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 0 41161002

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