Affinage

BBS2

BBSome complex member BBS2 · UniProt Q9BXC9

Length
721 aa
Mass
79.8 kDa
Annotated
2026-06-09
73 papers in source corpus 10 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BBS2 is a core subunit of the BBSome, a multiprotein complex that governs the protein composition of cilia by mediating the trafficking of membrane receptors into and out of the ciliary compartment (PMID:23351336). In photoreceptors, BBS2 is required for transport of rhodopsin to the outer segment, and its loss causes rhodopsin mislocalization followed by apoptotic photoreceptor death after otherwise normal retinal development (PMID:15539463); cone photoreceptor degeneration with accompanying microglial neuroinflammation is similarly seen upon bbs2 loss in zebrafish (PMID:33324636). More broadly, BBS2 supports ciliogenesis and ciliary receptor trafficking: restoring full-length BBS2 in patient fibroblasts carrying nonsense mutations rescues cilia formation, IFT88 ciliary localization, and correct localization of the GPCR SSTR3 (PMID:34365092). The BBSome works in concert with the intraflagellar transport (IFT) machinery to control Hedgehog signaling, as BBS loss leads to accumulation of Smoothened and Patched 1 in cilia and blunted Shh responses (PMID:22228099), and the complex and the small GTPase ARL6/BBS3 are mutually dependent for ciliary localization and proper trafficking of ciliary GPCRs (PMID:22139371). Consistent with these molecular roles, Bbs2-null mice display a ciliopathy spectrum including retinopathy, renal cysts, male infertility, and olfactory deficits (PMID:15539463). BBS2 shares structural motifs with BBS1 and BBS7, defining a conserved BBS protein domain (PMID:12567324). Reported nuclear localization of BBS2 (PMID:37034981) and a role as a negative regulator of adipogenesis (PMID:35718089) remain functionally uncharacterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2003 Medium

    Establishing that BBS2 belongs to a conserved family with shared structural motifs answered whether BBS proteins are related, and predicted additional BBS genes from sequence homology.

    Evidence Phylogenetic and comparative genomic analysis of human and zebrafish BBS2 sequences with mutational analysis of the identified paralog BBS7

    PMID:12567324

    Open questions at the time
    • Domain identification is computational and does not assign a biochemical function
    • Does not establish whether the shared motif mediates complex assembly
  2. 2003 Medium

    Testing a disease-associated BBS2 missense mutation in cells answered whether pathogenic variants act by disrupting protein localization, linking genotype to a cellular defect.

    Evidence Transfection of mutant versus wild-type BBS2 into mammalian cells with immunofluorescence localization

    PMID:12837689

    Open questions at the time
    • Single lab, single immunofluorescence method with no mechanistic follow-up
    • Overexpression in transfected cells may not reflect endogenous behavior
    • Does not identify the normal subcellular destination of wild-type BBS2
  3. 2004 High

    A Bbs2-null mouse answered what cellular process BBS2 serves in vivo, showing it is required for rhodopsin transport in photoreceptors and for cilia-dependent functions across multiple tissues.

    Evidence Bbs2-/- knockout mouse with rhodopsin immunolocalization, retinal apoptosis histology, and multi-organ phenotyping

    PMID:15539463

    Open questions at the time
    • Does not define the biochemical step of rhodopsin transport BBS2 controls
    • Does not resolve whether photoreceptor death is cell-autonomous to the trafficking defect
  4. 2010 Low

    Knockdown in preadipocytes asked whether BBS2 has roles beyond cilia, suggesting it negatively regulates adipogenesis upstream of adipogenic transcription factors.

    Evidence siRNA knockdown of BBS2 in bovine preadipocytes with qPCR/western for PPARγ, FABP4, FASN and oil red O lipid staining

    PMID:35718089

    Open questions at the time
    • No rescue experiment to confirm specificity of the knockdown phenotype
    • Single lab in bovine cells; mechanism linking BBS2 to PPARγ unknown
    • Does not establish whether this is ciliary or non-ciliary in origin
  5. 2011 Medium

    Endogenous interaction studies answered how the BBSome is delivered to cilia, showing mutual dependence between the BBSome and the GTPase ARL6/BBS3 for ciliary localization and GPCR trafficking.

    Evidence Reciprocal endogenous co-immunoprecipitation, Bbs3-/- mouse, and immunofluorescence of MCHR1 and Smoothened in cilia

    PMID:22139371

    Open questions at the time
    • Centered on BBS3 rather than BBS2 directly
    • Does not isolate BBS2's specific contribution within the BBSome
  6. 2012 High

    Genetic and localization studies placed the BBSome in the Hedgehog pathway, showing BBS proteins act with IFT to control ciliary levels of Smoothened and Patched 1.

    Evidence BBS knockout mice, Bbs7-/-;Ift88-hypomorph epistasis, and ciliary immunofluorescence of Smoothened and Patched 1

    PMID:22228099

    Open questions at the time
    • Epistasis used Bbs7, not BBS2, as the BBSome representative
    • Does not define the molecular mechanism coupling BBSome to IFT
  7. 2012 Medium

    Reconstitution of a BBSome-like complex in Paramecium confirmed BBS2 as a complex subunit while revealing functional non-equivalence among subunits for ciliary channel retention.

    Evidence Co-immunoprecipitation/mass spectrometry of BBS1/2/4/5/7/8/9 and RNAi depletion with ciliary channel immunofluorescence

    PMID:23351336

    Open questions at the time
    • BBS2 depletion did not reproduce the channel-loss phenotype seen for other subunits, leaving its specific cargo role undefined
    • Single organism/lab
  8. 2020 Medium

    A zebrafish bbs2 mutant addressed the cellular consequence of degeneration, showing BBS2 is required for cone survival and that loss triggers neuroinflammation without regenerative Müller cell proliferation.

    Evidence Zebrafish bbs2 mutant with visual assays, cone density histology, microglial activation, and Müller cell proliferation readouts

    PMID:33324636

    Open questions at the time
    • Does not connect cone loss to a specific BBSome trafficking defect
    • Single lab
  9. 2021 Medium

    Pharmacological restoration of BBS2 in patient cells provided gain-of-function evidence that BBS2 is causally required for ciliogenesis and ciliary receptor trafficking.

    Evidence Readthrough drugs (ataluren, amlexanox) on patient fibroblasts with western blot and immunofluorescence for cilia, IFT88, and SSTR3

    PMID:34365092

    Open questions at the time
    • Single lab; patient-specific genetic background
    • Does not define the biochemical interaction by which BBS2 traffics SSTR3
  10. 2023 Low

    Subcellular fractionation raised the question of non-ciliary BBS2 function, documenting nuclear localization of BBS proteins including BBS2.

    Evidence Subcellular fractionation, immunocytochemistry, and NLS prediction across eukaryotes in human cells

    PMID:37034981

    Open questions at the time
    • Functional consequence of nuclear localization not established
    • Single lab; no nuclear interactors or activities identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The specific cargo-recognition role of BBS2 within the BBSome and the function of its reported nuclear and anti-adipogenic activities remain undefined.
  • No structural or biochemical map of BBS2's direct cargo or subunit contacts within the BBSome
  • Nuclear role of BBS2 unconnected to any molecular activity
  • Anti-adipogenic effect lacks rescue and mechanism

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3
Localization
GO:0005929 cilium 4 GO:0005634 nucleus 1
Pathway
R-HSA-9609507 Protein localization 3 R-HSA-162582 Signal Transduction 1 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
ARL6BBS1BBS4BBS5BBS7BBS8BBS9
Complex memberships
BBSome

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Bbs2-null mice develop retinopathy preceded by mislocalization of rhodopsin, indicating BBS2 is required for rhodopsin transport in photoreceptor cells. Photoreceptor cell death occurs by apoptosis after normal retinal development, placing BBS2 in the ciliary transport pathway of rhodopsin. Knockout mouse model (Bbs2-/-) with immunolocalization of rhodopsin and histological analysis of retinal apoptosis Proceedings of the National Academy of Sciences of the United States of America High 15539463
2004 Loss of Bbs2 in mice causes phenotypes consistent with cilia dysfunction, including renal cysts, male infertility, and olfactory deficits, establishing BBS2 as required for normal cilia-dependent processes across multiple tissues. Knockout mouse model (Bbs2-/-) with phenotypic analysis across multiple organ systems Proceedings of the National Academy of Sciences of the United States of America High 15539463
2003 BBS2 shares structural motifs with BBS1 and BBS7, defining a potential functional domain present in at least three BBS proteins; phylogenetic analysis of BBS2 led to identification of BBS7 as a paralog sharing overlapping sequence regions with BBS2. Phylogenetic and comparative genomic analysis of human and zebrafish BBS2 peptide sequences; mutational analysis of BBS7 American journal of human genetics Medium 12567324
2003 Introduction of a BBS2 missense mutation (identified in triallelic BBS families) into mammalian cells causes dramatic mislocalization of the BBS2 protein compared to wild-type, demonstrating that this mutation disrupts normal BBS2 subcellular localization. Transfection of mutant BBS2 construct into mammalian cells with immunofluorescence localization Human molecular genetics Medium 12837689
2012 BBS proteins, including those in the BBSome, interact genetically with the IFT pathway; loss of BBS genes results in accumulation of Smoothened and Patched 1 in cilia and decreased Shh response. Double knockout of Bbs7 with hypomorphic Ift88 causes embryonic lethality with developmental defects not seen in single mutants, placing BBS proteins as modulators of Shh pathway activity acting in concert with IFT. Knockout mouse models; genetic epistasis (Bbs7-/-; Ift88 hypomorph double mutant); immunofluorescence for Smoothened and Patched 1 in cilia Human molecular genetics High 22228099
2011 Endogenous BBS3 (ARL6) and the BBSome physically interact and depend on each other for their ciliary localization; loss of Bbs3 does not affect BBSome formation but disrupts normal ciliary localization of melanin concentrating hormone receptor 1 and affects retrograde transport of Smoothened inside cilia. Co-immunoprecipitation of endogenous proteins; knockout mouse model (Bbs3-/-); immunofluorescence localization of MCH receptor 1 and Smoothened in cilia Proceedings of the National Academy of Sciences of the United States of America Medium 22139371
2012 BBS1, 2, 4, 5, 7, 8, and 9 co-immunoprecipitate in Paramecium, supporting formation of a BBSome-like protein complex. RNAi depletion of BBS7, 8, or 9 (but not BBS2) caused selective loss of K+ channels and PKD2 from cilia, while BBS2 depletion by RNAi did not affect patterns of ciliary motility governed by ion channels. Co-immunoprecipitation and mass spectrometry; RNAi knockdown; immunofluorescence localization of ciliary channels Cilia Medium 23351336
2021 Translational readthrough-inducing drugs (PTC124/ataluren and amlexanox) restore full-length BBS2 protein in patient fibroblasts carrying nonsense mutations (BBS2 Y24*/R275*), rescue ciliogenesis defects, restore IFT88 ciliary expression, and correct mislocalization of the GPCR SSTR3, demonstrating that BBS2 is required for normal ciliogenesis and ciliary receptor trafficking. Drug treatment of patient-derived fibroblasts; western blot for protein expression; immunofluorescence for cilia number/length, IFT88, and SSTR3 localization EBioMedicine Medium 34365092
2020 Loss of bbs2 in zebrafish leads to progressive cone photoreceptor degeneration accompanied by microglial activation/neuroinflammation, but this is insufficient to trigger robust Müller cell proliferation for regeneration, establishing BBS2 as necessary for cone photoreceptor survival and identifying an inflammatory but non-regenerative response to bbs2-driven degeneration. Zebrafish bbs2 mutant; visual function assays; histological analysis of cone density; microglial activation quantification; Müller cell proliferation assay Frontiers in cell and developmental biology Medium 33324636
2010 BBS2 knockdown in bovine preadipocytes promotes adipogenesis and lipid accumulation by stimulating expression of PPARγ, FABP4, and FASN, placing BBS2 as a negative regulator of adipogenesis upstream of these adipogenic transcription factors/enzymes. siRNA knockdown of BBS2 in bovine preadipocytes; qPCR and western blot for PPARγ, FABP4, FASN; oil red O staining for lipid accumulation Genomics Low 35718089
2023 Nuclear localization of BBS proteins, including BBS2, was confirmed in human cells by subcellular fractionation and immunocytochemistry, suggesting BBS proteins have nuclear roles in addition to ciliary functions; this nuclear localization appears to have evolved independently of mitotic nuclear access. Subcellular fractionation; immunocytochemistry; nuclear localization signal prediction across eukaryotes iScience Low 37034981

Source papers

Stage 0 corpus · 73 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proceedings of the National Academy of Sciences of the United States of America 306 15539463
2004 Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes & development 285 15231740
2004 Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nature genetics 267 15322545
2006 BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus. Nature genetics 223 16582908
2001 Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2). Human molecular genetics 206 11285252
2003 Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome. American journal of human genetics 196 12677556
2006 Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome. American journal of human genetics 179 17160889
2003 Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2. American journal of human genetics 172 12567324
2003 Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus. Human molecular genetics 153 12837689
2012 BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Human molecular genetics 117 22228099
2012 The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Molecular biology of the cell 116 22767577
2011 Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proceedings of the National Academy of Sciences of the United States of America 115 22139371
2013 BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Human molecular genetics 95 23943788
2010 Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Journal of medical genetics 71 20472660
2000 Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate. Journal of bacteriology 70 10629170
2005 Testing for triallelism: analysis of six BBS genes in a Bardet-Biedl syndrome family cohort. European journal of human genetics : EJHG 61 15770229
2011 U1 snRNA-mediated gene therapeutic correction of splice defects caused by an exceptionally mild BBS mutation. Human mutation 58 21520335
2012 Paramecium BBS genes are key to presence of channels in Cilia. Cilia 44 23351336
2009 Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease. Proceedings of the National Academy of Sciences of the United States of America 44 19666486
2006 Screening of the eight BBS genes in Tunisian families: no evidence of triallelism. Investigative ophthalmology & visual science 44 16877420
2006 Pitfalls of homozygosity mapping: an extended consanguineous Bardet-Biedl syndrome family with two mutant genes (BBS2, BBS10), three mutations, but no triallelism. European journal of human genetics : EJHG 41 16823392
2015 Association between missense mutations in the BBS2 gene and nonsyndromic retinitis pigmentosa. JAMA ophthalmology 40 25541840
2015 Targeted multi-gene panel testing for the diagnosis of Bardet Biedl syndrome: Identification of nine novel mutations across BBS1, BBS2, BBS4, BBS7, BBS9, BBS10 genes. European journal of medical genetics 39 26518167
2010 Molecular diagnosis reveals genetic heterogeneity for the overlapping MKKS and BBS phenotypes. European journal of medical genetics 35 21044901
2019 Mutation profile of BBS genes in patients with Bardet-Biedl syndrome: an Italian study. Italian journal of pediatrics 33 31196119
2010 New mutations in BBS genes in small consanguineous families with Bardet-Biedl syndrome: detection of candidate regions by homozygosity mapping. Molecular vision 33 20142850
2008 Electron-transfer subunits of the NiFe hydrogenases in Thiocapsa roseopersicina BBS. The FEBS journal 33 19019079
2020 Cone Photoreceptor Degeneration and Neuroinflammation in the Zebrafish Bardet-Biedl Syndrome 2 (bbs2) Mutant Does Not Lead to Retinal Regeneration. Frontiers in cell and developmental biology 31 33324636
2016 Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice. Journal of genetics and genomics = Yi chuan xue bao 30 27312011
2014 Mutation spectrum in BBS genes guided by homozygosity mapping in an Indian cohort. Clinical genetics 29 24400638
2001 Apoptosis and disease progression in the spontaneously diabetic BB/S rat. Diabetologia 29 11317663
2004 Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line. Journal of molecular medicine (Berlin, Germany) 27 15007513
2011 Differentiating Alström from Bardet-Biedl syndrome (BBS) using systematic ciliopathy genes sequencing. Ophthalmic genetics 26 22004009
2014 Mutation profile of BBS genes in Iranian patients with Bardet-Biedl syndrome: genetic characterization and report of nine novel mutations in five BBS genes. Journal of human genetics 24 24849935
2011 BBS mutational analysis: a strategic approach. Ophthalmic genetics 24 21463199
2021 Ocular Characteristics of Patients With Bardet-Biedl Syndrome Caused by Pathogenic BBS Gene Variation in a Chinese Cohort. Frontiers in cell and developmental biology 20 33777945
2021 Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts. EBioMedicine 19 34365092
1990 Intake of individual macronutrients following IP injections of BBS and CCK in rats. Peptides 19 2356153
2021 BBS Proteins Affect Ciliogenesis and Are Essential for Hedgehog Signaling, but Not for Formation of iPSC-Derived RPE-65 Expressing RPE-Like Cells. International journal of molecular sciences 17 33572860
2010 A founder mutation in BBS2 is responsible for Bardet-Biedl syndrome in the Hutterite population: utility of SNP arrays in genetically heterogeneous disorders. Clinical genetics 17 20618352
2010 A second soluble Hox-type NiFe enzyme completes the hydrogenase set in Thiocapsa roseopersicina BBS. Applied and environmental microbiology 16 20543059
2015 Whole Exome Sequencing Identifies a Novel and a Recurrent Mutation in BBS2 Gene in a Family with Bardet-Biedl Syndrome. BioMed research international 14 26078953
2022 Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes. Genetics 13 34850872
2021 A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities. Human molecular genetics 13 33560420
2014 Connection between the membrane electron transport system and Hyn hydrogenase in the purple sulfur bacterium, Thiocapsa roseopersicina BBS. Biochimica et biophysica acta 12 25111750
2005 No evidence for triallelic inheritance of MKKS/BBS loci in Amish Mckusick-Kaufman syndrome. American journal of medical genetics. Part A 12 16104012
2005 Hydrogen independent expression of hupSL genes in Thiocapsa roseopersicina BBS. The FEBS journal 12 16156799
2023 Usher syndrome proteins ADGRV1 (USH2C) and CIB2 (USH1J) interact and share a common interactome containing TRiC/CCT-BBS chaperonins. Frontiers in cell and developmental biology 11 37427378
2023 Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes. iScience 9 37034981
2022 The role of BBS2 in regulating adipogenesis and the association of its sequence variants with meat quality in Qinchuan cattle. Genomics 8 35718089
2021 Novel Compound Heterozygous BBS2 and Homozygous MKKS Variants Detected in Chinese Families with Bardet-Biedl Syndrome. Journal of ophthalmology 8 33520300
2013 Carrier frequency of two BBS2 mutations in the Ashkenazi population. Clinical genetics 8 23829372
2023 Clinical and molecular diagnosis of Bardet-Biedl syndrome (BBS). Methods in cell biology 6 37164534
2021 A Missense Variant in the Bardet-Biedl Syndrome 2 Gene (BBS2) Leads to a Novel Syndromic Retinal Degeneration in the Shetland Sheepdog. Genes 6 34828377
2022 Dental Anomalies in Ciliopathies: Lessons from Patients with BBS2, BBS7, and EVC2 Mutations. Genes 5 36672825
2023 Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience 4 37293546
2023 Changes in expression of mesothelial BBS genes in 2D and 3D after lithium chloride and ammonium sulphate induction of primary cilium disturbance: a pilot study. Pharmacological reports : PR 4 37542187
2025 The BBS/CCT chaperonin complex ensures the localization of the adhesion G protein-coupled receptor ADGRV1 to the base of primary cilia. Frontiers in cell and developmental biology 3 40103630
2022 Novel mutations in BBS genes and clinical characterization of Chinese families with Bardet-Biedl syndrome. European journal of ophthalmology 3 36325687
2014 Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7. PloS one 3 25486278
2024 Clinical features of a novel compound heterozygous genotype of the BBS2 gene: a case report. The Journal of international medical research 2 39175229
2021 Generation of induced pluripotent stem cells from a Bardet-Biedl syndrome patient carrying a homologous BBS2 c.534 + 1G > T mutation. Stem cell research 2 34364070
2025 Computational Evidence for Digenic Contribution of AIPL1 and BBS2 Rare Variants in Inherited Retinal Dystrophy. International journal of molecular sciences 1 41096698
2024 BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues. Differentiation; research in biological diversity 1 38215537
2024 Characterizing Homozygous Variants in Bardet-Biedl Syndrome-Associated Genes Within Iranian Families: Unveiling a Founder Variant in BBS2, c.471G>A. Biochemical genetics 1 38407766
2021 Identification of a Novel Homozygous Missense (c.443A>T:p.N148I) Mutation in BBS2 in a Kashmiri Family with Bardet-Biedl Syndrome. BioMed research international 1 33688495
2014 Interaction of HydSL hydrogenase from the purple sulfur bacterium Thiocapsa roseopersicina BBS with methyl viologen and positively charged polypeptides. Biochemistry. Biokhimiia 1 25365490
2026 A novel protein truncating mutation of TTC8 causes Bardet-Biedl Syndrome (BBS) in a Pakistani family. Genetics and molecular biology 0 41686921
2025 Homology search confirms widespread presence of BBSome proteins in Hexapoda with implications for potential non-ciliary BBS protein functions in honey bees. Scientific reports 0 41039016
2021 Compound Heterozygous Mutations in the BBS-1 Gene and its Clinical Presentation: A Case Report. Puerto Rico health sciences journal 0 34792930
1995 The accessibility of thiophosphorylated groups in DNA fragments to the enzymatic activity of ligases and restriction endonuclease Bbs I. Biochemistry and molecular biology international 0 7580999
1994 White blood cell depletion of single-donor platelet preparations using the new adsorption filter biofil P 10 BBS. Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine 0 9422101
1994 [Exceptional production of leukocyte-free erythrocyte concentrates using filtration with the BPF 4 BBS leukocyte filter]. Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine 0 9480117

Missed literature

Know a paper Affinage missed for BBS2? Flag it for the maintainers and the community.

No submissions yet.