Affinage

BBS9

Protein PTHB1 · UniProt Q3SYG4

Round 2 corrected
Length
887 aa
Mass
99.3 kDa
Annotated
2026-04-28
130 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BBS9 is a core structural subunit of the BBSome, a hetero-octameric complex (BBS1/2/4/5/7/8/9) that mediates trafficking of membrane proteins—including GPCRs and the Hedgehog transducer Smoothened—to and from the primary cilium (PMID:17574030, PMID:22072986). BBS9 nucleates BBSome assembly by forming a trimeric core with BBS2 and BBS7, onto which BBS1, BBS5, BBS8, and BBS4 are sequentially added in a process requiring the BBS6/10/12-CCT/TRiC chaperonin complex (PMID:22500027, PMID:20080638). Ciliary entry of the BBS9-containing BBSome is regulated by ARL6/BBS3, LZTFL1, and AZI1/CEP131, while transition-zone proteins NPHP5 and CEP290 maintain BBSome integrity at the ciliary gate (PMID:22139371, PMID:24550735, PMID:25552655). Loss-of-function mutations in BBS9 cause Bardet-Biedl syndrome, a ciliopathy characterized by retinal degeneration, obesity, and renal anomalies (PMID:16380913, PMID:22479622).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2005 High

    Identification of BBS9 as a Bardet-Biedl syndrome gene established that PTHB1 functions in ciliopathy pathogenesis, linking a previously orphan locus to the BBS disease network.

    Evidence Homozygosity mapping with SNP arrays, comparative genomics, and mutation screening in BBS patients

    PMID:16380913

    Open questions at the time
    • No protein-level function or interaction partners defined
    • Mechanism by which BBS9 loss causes BBS phenotypes unknown
  2. 2007 High

    Discovery of the BBSome as a stable seven-subunit complex containing BBS9 that localizes to centriolar satellites and ciliary membranes revealed BBS9's primary molecular context and established that the BBSome is required for ciliogenesis.

    Evidence Tandem affinity purification, mass spectrometry, co-immunoprecipitation, immunofluorescence, and zebrafish knockdown

    PMID:17574030

    Open questions at the time
    • Order of BBSome assembly and specific role of BBS9 within the complex unknown
    • Ciliary cargo identity largely undefined
  3. 2010 High

    Demonstration that BBSome assembly requires the BBS6/10/12-CCT/TRiC chaperonin complex defined a quality-control step upstream of functional BBSome formation.

    Evidence Co-immunoprecipitation and zebrafish knockdown with assembly-state readouts

    PMID:20080638

    Open questions at the time
    • Which BBSome subunits are direct chaperonin substrates remained unclear
    • Whether BBS9 itself requires chaperonin folding not tested
  4. 2011 High

    Identification of LZTFL1 and BBS3/ARL6 as regulators of BBSome ciliary trafficking, and Smoothened as a BBSome cargo, defined the pathway controlling ciliary entry and established a functional output of BBSome-mediated transport.

    Evidence Endogenous co-immunoprecipitation, Bbs3 knockout mouse, siRNA knockdowns with ciliary cargo trafficking readouts

    PMID:22072986 PMID:22139371

    Open questions at the time
    • Whether LZTFL1 and ARL6 act at the same or distinct regulatory steps unresolved
    • Full spectrum of BBSome-dependent ciliary cargos not catalogued
  5. 2012 High

    Biochemical trapping of assembly intermediates revealed that BBS9 forms a core trimer with BBS2 and BBS7 that serves as the nucleation scaffold for sequential BBSome assembly, placing BBS9 at the earliest step of complex biogenesis.

    Evidence Point mutagenesis, null allele analysis, and co-immunoprecipitation of assembly intermediates

    PMID:22500027

    Open questions at the time
    • Structural basis of BBS9-BBS2-BBS7 core interaction unknown
    • Whether the core trimer has independent function apart from scaffolding full BBSome not tested
  6. 2012 High

    Loss-of-function studies in zebrafish and mouse cells confirmed a conserved essential role for BBS9 in ciliogenesis and demonstrated that a patient-derived missense mutation is functionally null.

    Evidence Morpholino knockdown in zebrafish, siRNA in IMCD3 cells, mRNA rescue with wild-type versus mutant BBS9

    PMID:22479622

    Open questions at the time
    • Mechanism by which BBS9 loss abolishes cilia not distinguished from general BBSome disruption
    • Cell-type specificity of ciliogenesis requirement not explored
  7. 2013 High

    Demonstration that BBS4 links the BBSome to CEP290 at the transition zone, and that genetic interaction between Bbs4 and Cep290 accelerates retinal degeneration, connected BBSome function to transition-zone gating.

    Evidence Co-immunoprecipitation, immunofluorescence at the transition zone, double-mutant mouse phenotyping

    PMID:23943788

    Open questions at the time
    • Direct BBS9-CEP290 binding not tested
    • Mechanism by which transition-zone interaction facilitates cargo transport unclear
  8. 2014 High

    Identification of NPHP5 as a BBSome integrity factor and AZI1/CEP131 as a negative regulator of BBSome ciliary entry defined two distinct checkpoints—complex stability and ciliary gate access—both upstream of BBS9-containing BBSome function.

    Evidence Co-immunoprecipitation with domain-mapping, siRNA epistasis experiments, zebrafish morpholino knockdown

    PMID:24550735 PMID:25552655

    Open questions at the time
    • How NPHP5 selectively stabilizes BBS2 and BBS5 while BBS9 remains in the sub-complex is structurally unexplained
    • Whether AZI1 directly contacts BBS9 or acts only through BBS4 not resolved
  9. 2016 High

    Large-scale ciliary interactome mapping placed BBS9 within a broader network of 4,905 interactions and confirmed that patient-derived variants in BBSome subunits disrupt specific interactions, validating the clinical relevance of the BBSome interaction architecture.

    Evidence Affinity purification–mass spectrometry of 217 ciliary proteins with biochemical validation and variant analysis

    PMID:27173435

    Open questions at the time
    • Functional consequence of individual BBS9 interaction losses on cargo trafficking not measured
    • Stoichiometry of sub-complexes not determined
  10. 2017 High

    Amino-acid-resolution interaction profiling of all BBSome subunits mapped >1,000 interaction-disrupting mutations, creating a framework to interpret BBS9 patient variants mechanistically.

    Evidence Systematic yeast two-hybrid mutagenesis with next-generation sequencing readout

    PMID:29039417

    Open questions at the time
    • Yeast two-hybrid interactions not all validated in mammalian cells
    • Structural model of full BBSome at atomic resolution not yet available at the time

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structural model of BBS9 within the assembled BBSome, the precise mechanism by which the BBS9-BBS2-BBS7 core nucleates assembly, and the full repertoire of BBSome-dependent ciliary cargos whose trafficking requires BBS9 remain to be defined.
  • No atomic-resolution structure of BBS9 within the BBSome reported in this timeline
  • Cargo selectivity determinants on BBS9 not mapped
  • Whether BBS9 has functions independent of the BBSome is untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005929 cilium 4 GO:0005815 microtubule organizing center 2
Pathway
R-HSA-1643685 Disease 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-5653656 Vesicle-mediated transport 3
Partners
ARL6BBS1BBS2BBS4BBS5BBS7BBS8LZTFL1
Complex memberships
BBSomeBBSome core complex (BBS2-BBS7-BBS9)

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 BBS9 (parathyroid hormone-responsive B1/PTHB1) was identified as a novel Bardet-Biedl syndrome gene through homozygosity mapping, comparative genomic analysis, and gene expression studies in BBS-knockout mice; homozygous mutations in BBS patients confirmed its causative role in BBS. Homozygosity mapping with SNP arrays, comparative genomics, gene expression profiling, mutation screening American journal of human genetics High 16380913
2007 BBS9 is a subunit of the BBSome, a stable complex of seven BBS proteins (BBS1, 2, 4, 5, 7, 8, 9) that localizes to centriolar satellites and the ciliary membrane and is required for ciliogenesis and ciliary membrane biogenesis; the BBSome cooperates with the Rab8 GEF to promote ciliary membrane extension. Affinity purification, mass spectrometry, co-immunoprecipitation, zebrafish knockdown phenotyping, immunofluorescence Cell High 17574030
2010 BBSome assembly requires BBS6/BBS10/BBS12-CCT/TRiC chaperonin complex activity; BBS9 is part of the assembled BBSome whose formation depends on this chaperonin-mediated process. Co-immunoprecipitation, zebrafish knockdown, immunofluorescence, cell-based assembly assays Proceedings of the National Academy of Sciences of the United States of America High 20080638
2012 BBS9 forms a core BBSome assembly intermediate with BBS7 and BBS2 (the 'BBSome core complex'), which serves as the nucleation scaffold onto which BBS1, BBS5, BBS8, and BBS4 are sequentially added; the BBS-chaperonin complex (BBS6/10/12) stabilizes BBS7 prior to its incorporation into the BBS7-BBS2-BBS9 core. Point mutagenesis, null allele analysis, co-immunoprecipitation to trap assembly intermediates, immunofluorescence The Journal of biological chemistry High 22500027
2012 Knockdown of bbs9 in zebrafish causes developmental abnormalities including retinal defects, hydrocephaly, and reduced number and length of cilia in Kupffer's vesicle; knockdown of Bbs9 in mouse IMCD3 cells results in absence of cilia; a BBS patient-derived missense mutation in BBS9 fails to rescue the zebrafish morphant phenotype, demonstrating a conserved essential role in ciliogenesis. Antisense morpholino knockdown in zebrafish, siRNA knockdown in IMCD3 cells, mRNA rescue experiments, immunofluorescence PloS one High 22479622
2011 LZTFL1 interacts with the BBSome (including BBS9 as a subunit) and regulates its ciliary trafficking; all BBSome subunits including BBS9 are required for BBSome ciliary entry, and BBSome-mediated ciliary trafficking of the Hedgehog signal transducer Smoothened depends on BBSome integrity. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, zebrafish assays PLoS genetics High 22072986
2011 BBS4 (a BBSome subunit) binds the N-terminal region of CEP290, and the BBSome (containing BBS9) co-localizes with CEP290 at the transition zone and centriolar satellites; loss of BBSome subunits disrupts CEP290 localization at centriolar satellites; genetic interaction between Bbs4 and Cep290(rd16) alleles in mice accelerates photoreceptor degeneration and increases body weight, demonstrating BBSome-CEP290 functional interaction. Co-immunoprecipitation, immunofluorescence, double-mutant mouse crosses, phenotypic analysis Human molecular genetics High 23943788
2013 BBS3 (ARL6) physically interacts with the endogenous BBSome (which contains BBS9) and both depend on each other for ciliary localization; loss of Bbs3 does not affect BBSome formation but disrupts normal localization of melanin concentrating hormone receptor 1 to ciliary membranes and affects retrograde transport of Smoothened in cilia. Co-immunoprecipitation of endogenous proteins, Bbs3 knockout mouse model, immunofluorescence, ciliary trafficking assays Proceedings of the National Academy of Sciences of the United States of America High 22139371
2014 NPHP5 contains two separate BBS-binding sites and interacts with the BBSome to maintain its integrity; depletion of NPHP5 causes dissociation of BBS2 and BBS5 from the BBSome without affecting other subunits including BBS9, while Cep290 depletion causes additional loss of BBS8 — demonstrating that BBS9 remains in a stable sub-complex with BBS1, BBS4, BBS7, and BBS8 when BBS2/BBS5 are lost. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, ciliary cargo trafficking assays Human molecular genetics High 25552655
2014 AZI1/CEP131 (a centriolar satellite protein) interacts with the BBSome through BBS4; AZI1 is not involved in BBSome assembly but regulates BBSome ciliary trafficking; depletion of AZI1 enhances BBSome accumulation in cilia and rescues BBSome ciliary trafficking in BBS3- or BBS5-depleted cells, demonstrating a regulatory role upstream of BBSome ciliary entry. Co-immunoprecipitation, siRNA knockdown, immunofluorescence, zebrafish morpholino knockdown PLoS genetics High 24550735
2016 Affinity proteomics of 217 tagged ciliary proteins identified BBS9 within a defined ciliary protein interaction landscape comprising 1,319 proteins and 4,905 interactions; BBS9-containing BBSome sub-complexes were validated biochemically and structurally predicted disruptive variants from ciliopathy patients were confirmed to perturb these interactions. Affinity purification–mass spectrometry, biochemical validation, genetic variant analysis Nature communications High 27173435
2017 Systematic yeast two-hybrid mutagenesis profiling across eight BBSome subunits including BBS9 identified >1,000 interaction-disrupting amino acid mutations; this defined amino-acid-resolution interaction determinants for BBS9 within the BBSome and provided a framework for interpreting patient-derived BBS9 mutations. Yeast two-hybrid 'off-switch' selection, massively parallel programmed mutagenesis, next-generation sequencing readout Nature methods High 29039417
2012 A genome-wide association study identified a susceptibility locus for nonsyndromic sagittal craniosynostosis within a 167-kb region of BBS9, implicating BBS9 in skeletal/calvarial development independent of its ciliopathy role. Genome-wide association study with case-parent trios and replication cohort Nature genetics Low 23160099
2018 Long-read SMRT sequencing precisely mapped breakpoints of a homozygous BBS9 deletion (exons 1-4) in a patient with Bardet-Biedl syndrome, and determined that non-homologous end joining was the likely mechanism of formation; loss of BBS9 function (exons 1-4 deleted) produces the full BBS clinical phenotype. Chromosomal microarray, BBS gene panel sequencing, long-read SMRT sequencing NPJ genomic medicine Medium 29367880

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2007 A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 1145 17574030
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
1994 Expression cloning of a human B1 bradykinin receptor. The Journal of biological chemistry 387 8063797
2004 Lamin B1 is required for mouse development and nuclear integrity. Proceedings of the National Academy of Sciences of the United States of America 332 15232008
2010 BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Proceedings of the National Academy of Sciences of the United States of America 258 20080638
2008 A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Developmental cell 255 19081074
2011 Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic acids research 251 22053081
2004 Ephrin-B1 forward and reverse signaling are required during mouse development. Genes & development 243 15037550
1998 Activation and detoxication of aflatoxin B1. Mutation research 236 9675258
1995 Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. The EMBO journal 229 7737117
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2013 Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. The Journal of cell biology 205 23439683
2004 Mutations of the ephrin-B1 gene cause craniofrontonasal syndrome. American journal of human genetics 189 15124102
2005 Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene. American journal of human genetics 167 16380913
2011 A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS genetics 165 22072986
2003 Cyclin B1 and CDK1: nuclear localization and upstream regulators. Progress in cell cycle research 163 14593728
2000 Development and function of B-1 cells. Current opinion in immunology 161 10858035
2003 Human chromosome 7: DNA sequence and biology. Science (New York, N.Y.) 154 12690205
2001 Over-expression of FoxM1 stimulates cyclin B1 expression. FEBS letters 152 11682060
2012 Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome. The Journal of biological chemistry 139 22500027
2020 The roles of hnRNP A2/B1 in RNA biology and disease. Wiley interdisciplinary reviews. RNA 132 32588964
2005 The potential role of thiamine (vitamin B1) in diabetic complications. Current diabetes reviews 124 18220605
2011 Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes. Proceedings of the National Academy of Sciences of the United States of America 115 22139371
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
1997 Overexpression of cyclin B1 in human colorectal cancers. Journal of cancer research and clinical oncology 114 9030252
2023 The importance of thiamine (vitamin B1) in humans. Bioscience reports 111 37389565
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
2018 Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Molecular & cellular proteomics : MCP 101 30021884
2018 Cytogenomic identification and long-read single molecule real-time (SMRT) sequencing of a Bardet-Biedl Syndrome 9 (BBS9) deletion. NPJ genomic medicine 99 29367880
2012 A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9. Nature genetics 97 23160099
2004 B1-phytoprostanes trigger plant defense and detoxification responses. Plant physiology 97 15618427
2021 AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal transduction and targeted therapy 95 34373448
2013 BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Human molecular genetics 95 23943788
2010 Roles of Sema4D and Plexin-B1 in tumor progression. Molecular cancer 91 20858260
2011 IL-33 activates B1 cells and exacerbates contact sensitivity. Journal of immunology (Baltimore, Md. : 1950) 86 21239718
1993 Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. Molecular pharmacology 84 8394991
2009 A differentiation pathway for B1 cells in adult bone marrow. Proceedings of the National Academy of Sciences of the United States of America 83 19307589
2019 B-1 cell responses to infections. Current opinion in immunology 81 30685692
1988 Mutation in GM2-gangliosidosis B1 variant. Journal of neurochemistry 79 2961848
1995 Cloning and pharmacological characterization of a rabbit bradykinin B1 receptor. Biochimica et biophysica acta 78 7495867
2014 Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery. Human molecular genetics 75 25552655
2017 Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes. Oncotarget 73 28030812
2013 Linking vitamin B1 with cancer cell metabolism. Cancer & metabolism 72 24280319
2020 Nanozyme and aptamer- based immunosorbent assay for aflatoxin B1. Journal of hazardous materials 71 32937727
2015 Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat. International journal of obesity (2005) 68 26480920
2013 Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. The Journal of clinical investigation 68 23676464
2000 Generation, expansion, migration and activation of mouse B1 cells. Immunological reviews 68 11043779
2018 Sirt1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1. Aging 67 30368232
1992 The role of B1- and B2-kinin receptors in the renal tubular and hemodynamic response to bradykinin. The American journal of physiology 65 1310238
2012 Human b1 cell frequency: isolation and analysis of human b1 cells. Frontiers in immunology 63 22654880
2014 Role of lamin b1 in chromatin instability. Molecular and cellular biology 61 25535332
2018 Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I. The Journal of cell biology 59 30097513
2018 DNA damage checkpoint response to aflatoxin B1. Environmental toxicology and pharmacology 59 30594067
2022 Structural perspective of class B1 GPCR signaling. Trends in pharmacological sciences 57 35078643
2016 The B1 Protein Guides the Biosynthesis of a Lasso Peptide. Scientific reports 55 27752134
2006 Ephrin-B1 is critical in T-cell development. The Journal of biological chemistry 55 16476740
2004 The dynamics of cyclin B1 distribution during meiosis I in mouse oocytes. Reproduction (Cambridge, England) 55 15280554
2018 Total Enzyme Syntheses of Napyradiomycins A1 and B1. Journal of the American Chemical Society 52 30525563
1992 Cyclins A and B1 in the human cell cycle. Ciba Foundation symposium 52 1483345
2002 The effects of mycotoxins, fumonisin B1 and aflatoxin B1, on primary swine alveolar macrophages. Toxicology and applied pharmacology 50 12009859
1990 Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Applied and environmental microbiology 49 2111122
2018 Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence. Cells 48 29415520
2015 Perspectives on fetal derived CD5+ B1 B cells. European journal of immunology 48 26339791
2002 DNA damage in astrocytes exposed to fumonisin B1. Neurochemical research 48 11958538
1996 B1 bradykinin receptors and sensory neurones. British journal of pharmacology 48 8832074
2023 Class B1 GPCR activation by an intracellular agonist. Nature 46 37286611
2000 Mechanisms of aflatoxin B1 lung tumorigenesis. Experimental lung research 45 11195464
2020 Thiamine (vitamin B1) in septic shock: a targeted therapy. Journal of thoracic disease 44 32148929
2012 Knockdown of Bardet-Biedl syndrome gene BBS9/PTHB1 leads to cilia defects. PloS one 44 22479622
2003 Benzodiazepines as potent and selective bradykinin B1 antagonists. Journal of medicinal chemistry 44 12723943
2001 Analysis of fumonisin B1-induced apoptosis. Environmental health perspectives 43 11359701
2008 Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists. The Journal of biological chemistry 42 18187413
2021 Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage. Science advances 41 34452908
2018 The Dual Face of Cyclin B1. Trends in plant science 41 29680634
2010 Blockade of the kinin B1 receptor ameloriates glomerulonephritis. Journal of the American Society of Nephrology : JASN 41 20448019
2009 Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. The Journal of biological chemistry 41 19805544
2007 Unraveling B-1 progenitors. Current opinion in immunology 41 17303402
2015 The endoplasmic reticulum membrane J protein C18 executes a distinct role in promoting simian virus 40 membrane penetration. Journal of virology 39 25631089
2002 Initial activation of cyclin-B1-cdc2 kinase requires phosphorylation of cyclin B1. EMBO reports 39 12034754
2016 Response of the hepatic transcriptome to aflatoxin B1 in ducklings. Toxicon : official journal of the International Society on Toxinology 38 26763128
2017 Aflatoxin B1 impairs sperm quality and fertilization competence. Toxicology 37 29113834
2010 Scavenger receptor-B1 and luteal function in mice. Journal of lipid research 37 20404351
2015 Plexin-B1 signalling promotes androgen receptor translocation to the nucleus. Oncogene 36 25982277
2014 The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS genetics 35 24550735
2012 Analysis of fumonisin B1 removal by microorganisms in co-occurrence with aflatoxin B1 and the nature of the binding process. International journal of food microbiology 35 22503712
2002 Activation of bradykinin B1 receptor by ACE inhibitors. International immunopharmacology 35 12489793
2021 Remimazolam alleviates neuropathic pain via regulating bradykinin receptor B1 and autophagy. The Journal of pharmacy and pharmacology 34 34061162
2009 Metabolic intervention of aflatoxin B1 toxicity by curcumin. Journal of ethnopharmacology 34 20015472
1994 Quantitation and stability of fumonisins B1 and B2 in milk. Journal of AOAC International 34 7950418
2018 E3 ubiquitin ligase HECW2 targets PCNA and lamin B1. Biochimica et biophysica acta. Molecular cell research 33 29753763
2015 B-1 lymphocytes in mice and nonhuman primates. Annals of the New York Academy of Sciences 33 25930711
2011 Aflatoxin B1 and fumonisin B1 affect the oxidative status of bovine peripheral blood mononuclear cells. Toxicology in vitro : an international journal published in association with BIBRA 32 21256206
2006 An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer. Bioorganic & medicinal chemistry 32 17010619
2019 Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 31 31891755
2014 Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. Caries research 31 24556642
2008 Deletion of bradykinin B1 receptor reduces renal fibrosis. International immunopharmacology 31 19010452
2008 Aurora-A interacts with Cyclin B1 and enhances its stability. Cancer letters 31 19028417
2006 Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. The Biochemical journal 31 16187944
2017 Scavenger receptor B1 (SR-B1) profoundly excludes high density lipoprotein (HDL) apolipoprotein AII as it nibbles HDL-cholesteryl ester. The Journal of biological chemistry 30 28373285
2017 Protein interaction perturbation profiling at amino-acid resolution. Nature methods 30 29039417
2008 Parathyroid hormone-responsive B1 gene is associated with premature ovarian failure. Human reproduction (Oxford, England) 30 18349106
2007 Targeting the bradykinin B1 receptor to reduce pain. Expert opinion on therapeutic targets 30 17150032
2022 Impact of Mycotoxin Contaminations on Aquatic Organisms: Toxic Effect of Aflatoxin B1 and Fumonisin B1 Mixture. Toxins 28 36006180
2020 Kinin B1 receptor: A target for neuroinflammation in hypertension. Pharmacological research 28 32087235
2017 SR-B1 and PDZK1: partners in HDL regulation. Current opinion in lipidology 28 28134663
2016 Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 27277805
2011 Natural occurrence of aflatoxins (B₁ and M₁) in feed, plasma and raw milk of lactating dairy cows in Beja, Tunisia, using ELISA. Food additives & contaminants. Part B, Surveillance 28 24779689
2007 Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma. The American journal of pathology 28 17591954
2006 Expression profiling of cyclin B1 and D1 in cervical carcinoma. Experimental oncology 28 16614707
2021 Effects of Prenatal Exposure to Aflatoxin B1: A Review. Molecules (Basel, Switzerland) 27 34885894
2020 The immunomodulatory effect of cathelicidin-B1 on chicken macrophages. Veterinary research 27 32972448
2013 Regulation of nucleotide excision repair by nuclear lamin b1. PloS one 27 23894423
2009 Cell cycle-related cyclin b1 quantification. PloS one 27 19763267
2002 Progesterone upregulates TGF-b isoforms (b1, b2, and b3) expression in normal human osteoblast-like cells. Calcified tissue international 27 12154395
1983 The neurotoxicity of aflatoxin B1 in the rat. Toxicology 27 6138886
2022 SR-B1's Next Top Model: Structural Perspectives on the Functions of the HDL Receptor. Current atherosclerosis reports 26 35107765
2016 ACTH Regulation of Adrenal SR-B1. Frontiers in endocrinology 26 27242666
2004 Capped acyclic permutants of the circular protein kalata B1. FEBS letters 26 15556617
2012 FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival. Journal of immunology (Baltimore, Md. : 1950) 25 22516957
2022 Degradation of Aflatoxin B1 by recombinant laccase extracellular produced from Escherichia coli. Ecotoxicology and environmental safety 24 36108433
2014 Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke. Free radical biology & medicine 24 24423486
1992 Cytokines and Ly-1 (B1) B cells. International reviews of immunology 24 1602214