Affinage

Showing AURKA — AURA is a alias.

AURKA

Aurora kinase A · UniProt O14965

Length
403 aa
Mass
45.8 kDa
Annotated
2026-06-09
100 papers in source corpus 28 papers cited in narrative 29 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AURKA is a cell-cycle-regulated serine/threonine kinase that accumulates at G2/M and localizes to the spindle pole from prophase through anaphase, where it governs centrosome function and chromosome segregation (PMID:9153231); its amplification and overexpression in tumors drives centrosome amplification, aneuploidy, and oncogenic transformation (PMID:9174055, PMID:9771714). Catalytic activity is switched on by phosphorylation of Threonine 288 in the activation loop and switched off by PP1, with which AURKA forms a reciprocal regulatory loop—activated kinase phosphorylates and inhibits PP1, while PP1 dephosphorylates and inactivates the kinase (PMID:11039908, PMID:11551964). Distinct cofactors engage AURKA at separable sites to direct its localized functions: a crystal structure of AURKA bound to CEP192 Helix-1 defines a centrosomal regulatory interface distinct from the TPX2 binding site (PMID:37083534), and TPX2 co-overexpression additionally drives AURKA into the interphase nucleus (PMID:36797043). AURKA abundance is set by opposing ubiquitin machinery—the APC/C-FZR1 axis (modulated by PRL-3-mediated FZR1 dephosphorylation) and stabilizing/destabilizing E3 activity of CBLC, counterbalanced by the deubiquitinase USP21 (PMID:30498084, PMID:35149839, PMID:36919585). Beyond mitosis, AURKA acts kinase-independently in the nucleus by partnering with hnRNP K to transactivate MYC and promote a cancer stem cell phenotype (PMID:26782714), and as a kinase it phosphorylates substrates that rewire tumor-relevant signaling: HDM2/MDM2 to suppress p53 (PMID:24240108), KEAP1 to activate NRF2 and suppress ferroptosis (PMID:38642502), and SPOP to stabilize androgen receptor and c-Myc (PMID:33158056). It is also embedded in feedback circuits with metabolic and transcriptional regulators, including mitochondrial ATP synthase subunits that couple it to cell-cycle and metabolic fate (PMID:37386025).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1997 Medium

    Established AURKA as a chromosome-segregation kinase homologous to yeast Ipl1/Drosophila Aurora and linked its amplification to breast cancer, framing it as a candidate oncogene.

    Evidence cDNA cloning, sequence/homology analysis and chromosomal mapping (20q13) in breast tumor cell lines

    PMID:9174055

    Open questions at the time
    • No direct enzymatic assay in this study
    • Functional role inferred from homology only
  2. 1997 High

    Showed AURKA is cell-cycle regulated and spindle-pole-localized with mitotically enhanced kinase activity, placing it temporally and spatially within mitosis.

    Evidence Northern/Western blot, immunofluorescence and in vitro casein kinase assay across the cell cycle

    PMID:9153231

    Open questions at the time
    • Physiological substrates not identified
    • Mechanism of activation not addressed
  3. 1998 High

    Demonstrated causally that AURKA overexpression drives centrosome amplification, aneuploidy, and transformation, establishing the oncogenic mechanism behind its amplification.

    Evidence Ectopic expression in NIH 3T3 and human breast epithelial cells with soft-agar transformation and FISH

    PMID:9771714

    Open questions at the time
    • Did not define which catalytic substrates mediate centrosome amplification
    • In vivo relevance not tested here
  4. 2001 High

    Defined the activation switch (T288 autophosphorylation) and a reciprocal AURKA-PP1 antagonism that sets kinase activity and proper chromosome alignment.

    Evidence In vitro kinase/phosphatase assays, T288 and PP1-binding-site mutagenesis, okadaic acid, immunofluorescence

    PMID:11039908 PMID:11551964

    Open questions at the time
    • Physiological kinase activating T288 in cells not fully resolved
    • Downstream mitotic substrates not enumerated
  5. 1999 Medium

    Identified Cdc20 as an early-mitotic AURKA-associated protein, linking the kinase to the mitotic regulatory machinery.

    Evidence Co-immunoprecipitation from HeLa extracts with MBP kinase activity readout

    PMID:10377410

    Open questions at the time
    • Single Co-IP, no reciprocal validation
    • Functional consequence of the interaction not defined
  6. 2016 High

    Revealed a kinase-independent nuclear function in which AURKA partners hnRNP K to transactivate MYC, expanding AURKA biology beyond catalytic mitotic roles.

    Evidence Nuclear fractionation, Co-IP, ChIP/promoter assays, kinase-dead and localization-blocking mutants, mammosphere assays

    PMID:26782714

    Open questions at the time
    • Structural basis of hnRNP K binding unknown
    • Determinants of nuclear import only partly defined
  7. 2022 High

    Mapped the ubiquitin economy controlling AURKA levels by identifying writers, erasers, and stabilizers acting on distinct ubiquitin linkages.

    Evidence Co-IP/MS, linkage-specific ubiquitination assays, cycloheximide chase and synchronization (CBLC, APC/C-FZR1/PRL-3, USP21)

    PMID:30498084 PMID:35149839 PMID:36919585

    Open questions at the time
    • Relative contribution of each ligase across cell types unclear
    • Crosstalk between stabilizing and degrading linkages not fully resolved
  8. 2023 High

    Provided the structural basis for separable centrosomal versus spindle regulation by showing CEP192 Helix-1 binds AURKA at a site distinct from TPX2.

    Evidence X-ray crystallography, ITC/SPR binding measurements, cell-based interaction-disrupting mutations

    PMID:37083534

    Open questions at the time
    • Conformational consequences of dual cofactor engagement not resolved
    • How localization-specific activation selects substrates unknown
  9. 2023 Medium

    Extended AURKA's substrate repertoire and feedback circuitry into tumor signaling and metabolism, defining KEAP1/NRF2, SPOP/AR-Myc, and ATP synthase as effector nodes.

    Evidence In vitro kinase assays, Co-IP, ubiquitination assays, Seahorse metabolic analysis and in vivo models (KEAP1, SPOP, HDM2, ATP5F1A/B)

    PMID:24240108 PMID:33158056 PMID:37386025 PMID:38642502

    Open questions at the time
    • Many substrate interactions rest on single-lab Co-IP
    • Hierarchy among these effector pathways in vivo unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How distinct localized cofactor-bound AURKA states select specific substrates and balance catalytic versus kinase-independent outputs remains unresolved.
  • No unified model linking cofactor binding site to substrate choice
  • Structural basis for kinase-independent transcriptional functions undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 6 GO:0140096 catalytic activity, acting on a protein 5 GO:0140110 transcription regulator activity 2
Localization
GO:0005815 microtubule organizing center 3 GO:0005634 nucleus 2 GO:0005856 cytoskeleton 2 GO:0005739 mitochondrion 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-1643685 Disease 3 R-HSA-74160 Gene expression (Transcription) 2
Partners
CDC20CEP192HNRNP KKEAP1MDM2PP1SPOPTPX2
Complex memberships
APC/C-FZR1

Evidence

Reading pass · 29 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 AURKA (BTAK) encodes a serine/threonine kinase localized on chromosome 20q13 with homology to yeast Ipl1 and Drosophila Aurora, both involved in chromosome segregation; the gene is amplified and overexpressed in breast tumor cell lines. cDNA cloning, sequence analysis, chromosomal mapping Oncogene Medium 9174055
1997 AURKA (Aik) protein is cell-cycle regulated, accumulates during G2/M and decreases after mitosis, localizes to the spindle pole from prophase through anaphase, and exhibits kinase activity (casein phosphorylation) enhanced at mitosis. Northern blot, Western blot, immunofluorescence, in vitro kinase assay with exogenous casein substrate The Journal of biological chemistry High 9153231
1998 Ectopic overexpression of AURKA (STK15/BTAK) in mouse NIH 3T3 cells and near-diploid human breast epithelial cells induces centrosome amplification, aneuploidy, and oncogenic transformation, defining AURKA as a centrosome-associated kinase whose overexpression drives chromosomal instability. Ectopic expression in mammalian cells, immunofluorescence, soft-agar transformation assay, FISH Nature genetics High 9771714
1999 AURKA (Aurora2/Aik) associates with the cell cycle regulator Cdc20 in HeLa cells; Cdc20-associated kinase activity peaks in early M phase, identifying Cdc20 as an AURKA-interacting protein at mitotic spindle poles. Co-immunoprecipitation from HeLa cell extracts, kinase activity assay (MBP phosphorylation) Proceedings of the National Academy of Sciences of the United States of America Medium 10377410
2000 AURKA (Aurora2) is activated by phosphorylation of Threonine 288 within the activation loop; this phosphorylation increases enzymatic activity and can be catalyzed by PKA in vitro. Protein phosphatase 1 (PP1) dephosphorylates T288 and inactivates AURKA in vitro; in vivo T288 phosphorylation is induced by okadaic acid. Additionally, AURKA is degraded via the proteasome, and T288-phosphorylated AURKA may be targeted for mitotic degradation. In vitro kinase assay, site-directed mutagenesis (T288 substitution), phosphatase assay with PP1, okadaic acid treatment, proteasome inhibitor experiments Oncogene High 11039908
2001 AURKA (STK15) contains two functional PP1-binding sites; STK15 and PP1 interact in a cell-cycle-dependent manner peaking at mitosis. Activated STK15 phosphorylates PP1 and inhibits its phosphatase activity in vitro and in vivo. Conversely, PP1 dephosphorylates and inactivates STK15. Non-binding STK15 mutants are superphosphorylated but have reduced kinase activity, and cells expressing these mutants show aberrant chromosome alignment. Co-immunoprecipitation, in vitro kinase assay, in vitro phosphatase assay, site-directed mutagenesis of PP1-binding motifs, immunofluorescence for chromosome alignment The Journal of biological chemistry High 11551964
2013 AURKA directly interacts with and phosphorylates HDM2 (MDM2) in vitro; this leads to P53 ubiquitination and attenuation of cisplatin-induced P53 activation in gastric cancer cells, promoting cell survival. Dual co-immunoprecipitation, in vitro kinase assay with recombinant AURKA and HDM2, ubiquitination assay, luciferase reporter for P53 activity Clinical cancer research High 24240108
2014 AURKA promotes STAT3 transcriptional activity through regulation of JAK2 expression and phosphorylation; overexpression of AURKA increases STAT3 Tyr705 phosphorylation and STAT3 nuclear translocation, whereas AURKA knockdown reduces these effects. Inhibition of JAK2 in the presence of AURKA overexpression abrogates AURKA-mediated STAT3 activation, establishing the AURKA-JAK2-STAT3 axis. siRNA knockdown, overexpression, immunofluorescence, luciferase reporter assay, JAK2-specific inhibitor (AZD1480), Western blot for phospho-STAT3 Molecular oncology Medium 24953013
2014 SMAD4 binds to AURKA and induces its proteasomal degradation in a TGFβ-independent manner, thereby suppressing AURKA-mediated β-catenin/TCF transcriptional activity and metastatic phenotypes. Co-immunoprecipitation, overexpression and knockdown, luciferase reporter assay for β-catenin/TCF, colony formation, migration and invasion assays Molecular cancer research Medium 25061104
2016 In the nucleus, AURKA translocates from centrosomes and performs kinase-independent oncogenic functions by interacting with hnRNP K to form a transcriptional complex that shifts MYC promoter usage and activates MYC transcription, thereby enhancing breast cancer stem cell phenotype. Blocking AURKA nuclear localization inhibits this transactivating function. Co-immunoprecipitation, nuclear fractionation, ChIP/promoter assays, kinase-dead mutants, nuclear localization-blocking constructs, mammosphere assays Nature communications High 26782714
2018 ARID1A occupies the AURKA gene promoter and negatively regulates AURKA transcription; loss of ARID1A results in enhanced AURKA transcription leading to persistent CDC25C activation and G2/M dysregulation, creating a synthetic lethal interaction exploitable therapeutically. ChIP assay, genetic knockout/knockdown, CDC25C activity assays, cell cycle analysis, xenograft models Nature communications High 30097580
2018 PRL-3 phosphatase interacts with AURKA and promotes its ubiquitination and proteasomal degradation by dephosphorylating FZR1, thereby activating the APC/C-FZR1 complex which targets AURKA. Co-immunoprecipitation, ubiquitination assay, phosphatase-dependent degradation assay, ectopic expression and knockdown, xenograft models Cancer research High 30498084
2018 AURKA directly phosphorylates SPOP at three sites, causing SPOP ubiquitination and degradation; SPOP in turn degrades AURKA via a feedback loop. AURKA-mediated SPOP degradation stabilizes androgen receptor (AR), ARv7, and c-Myc, driving castration-resistant prostate cancer progression. In vitro kinase assay identifying SPOP as direct AURKA substrate, co-immunoprecipitation, ubiquitination assay, site-directed mutagenesis (phospho-resistant SPOP), xenograft models Cancers High 33158056
2019 CEP41-mediated tubulin glutamylation of cilia activates AURKA and upregulates VEGFA/VEGFR2 expression through HIF1α during endothelial cell responses to shear stress or hypoxia, driving angiogenesis and cilia disassembly (deciliation). siRNA knockdown in human endothelial cells and zebrafish, immunofluorescence, Western blot, VEGF/HIF1α pathway analysis EMBO reports Medium 31885126
2020 AURKA kinase activity is required for the maintenance of ring-like aMTOC (acentriolar microtubule-organizing center) organization in mouse oocytes; inhibition of AURKA causes loss of aMTOC ring structure, CEP215 clustering at spindle poles, and shorter spindles with highly focused poles. Pharmacological AURKA inhibition in mouse oocytes (MI and MII stages), super-resolution microscopy, siRNA knockdown of Cep215 Reproduction (Cambridge, England) Medium 31895686
2021 AURKA deletion in spermatogonia eliminates all developing germ cells (consistent with its mitotic role), while deletion in spermatocytes increases spermatocyte apoptosis, elevates abnormal sperm morphology, and increases progressive sperm motility with decreased PP1 activity in sperm lysate. Conditional knockout mice (Cre-lox in spermatogonia or spermatocytes), fertility assays, sperm motility analysis, PP1 activity assay Biology of reproduction High 34518881
2022 CBLC (an E3 ubiquitin ligase) interacts with the kinase domain of AURKA and stabilizes it by conjugating monoubiquitination and K11/K63-linked polyubiquitination, protecting AURKA from degrading K11/K48 polyubiquitination. CBLC depletion decreases AURKA half-life and delays AURKA accumulation/activation during mitotic entry. Co-immunoprecipitation and mass spectrometry, ubiquitination assays with linkage-specific analysis, cycloheximide chase (half-life), cell synchronization with thymidine block, Western blot Oncogene High 35149839
2023 AURKA functionally interacts with mitochondrial ATP synthase subunits ATP5F1A and ATP5F1B (Complex V core subunits); disruption of this AURKA/ATP5F1A/ATP5F1B nexus triggers G0/G1 arrest accompanied by decreased glycolysis and mitochondrial respiration, with cell fate outcome dependent on the metabolic propensity of triple-negative breast cancer cells. Co-immunoprecipitation, pharmacological Complex V inhibition, AURKA abundance measurement, cell cycle analysis, Seahorse metabolic assays Cell death discovery Medium 37386025
2023 AURKA directly interacts with and phosphorylates KEAP1, thereby activating NRF2 and its target gene transcription, suppressing ferroptosis in meningioma; FOXM1 transcriptionally induces AURKA expression in this context. Co-immunoprecipitation, in vitro kinase assay, NRF2 target gene reporter/Western blot, FOXM1 ChIP/promoter assay, mouse meningioma model Redox biology Medium 38642502
2023 The crystal structure of AURKA bound to a conserved helix (Helix-1) from CEP192 reveals a distinct binding site on AURKA that is different from the TPX2 binding site; disrupting the CEP192 Helix-1/AURKA interaction in cells causes mitotic defects, establishing the structural basis for centrosomal AURKA regulation distinct from spindle-microtubule regulation by TPX2. Crystal structure determination (X-ray crystallography), quantitative binding studies (ITC/SPR), cell-based mutation experiments with mitotic defect readout Science advances High 37083534
2023 AURKA interacts with DDX5 to form a transcriptional coactivator complex that induces transcription of the lncRNA TMEM147-AS1, which in turn sponges hsa-let-7b/7c-5p to upregulate AURKA in a positive feedback loop maintaining cisplatin resistance via lipophagy activation in ovarian cancer. Co-immunoprecipitation (AURKA-DDX5), ChIP/promoter analysis, lncRNA sponge assays, lipophagy assays Cancer letters Medium 37217070
2023 CD73/NT5E directly interacts with AURKA (confirmed by co-IP and molecular docking) and inhibits AURKA ubiquitination; overexpression of CD73/NT5E stabilizes AURKA, downregulates p53 signaling, and regulates hepatic stellate cell activation and senescence in alcohol-related liver fibrosis. Co-immunoprecipitation, molecular docking, ubiquitination assay, mouse model of alcohol-related liver fibrosis International journal of biological sciences Medium 36778123
2023 TPX2 co-overexpression promotes AURKA nuclear accumulation in interphase, whereas AURKA overexpression alone is insufficient for nuclear accumulation. Nuclear export and proteasome activity also regulate nuclear AURKA levels. Nuclear AurkA driven by TPX2 co-overexpression promotes pro-tumorigenic processes in MCF10A mammospheres. Nuclear/cytoplasmic fractionation, live imaging, proteasome inhibition, co-overexpression experiments, mammosphere assay Life science alliance Medium 36797043
2023 USP21 deubiquitinase directly interacts with AURKA (confirmed by co-IP and GST-pulldown) and deubiquitinates AURKA to restore its activity and stability; USP21 knockdown increases AURKA ubiquitination and suppresses laryngeal cancer cell proliferation, migration, and invasion. Co-immunoprecipitation, GST-pulldown, ubiquitination assay, knockdown experiments with rescue by AURKA overexpression The Kaohsiung journal of medical sciences Medium 36919585
2021 AURKA inhibition suppresses differentiation of THP-1 AML cells by repressing KDM6B (H3K27 demethylase) expression; AURKA and YY1 co-occupy the KDM6B promoter region. Alisertib-mediated AURKA inhibition dissociates this complex, upregulates KDM6B, and drives THP-1 differentiation into monocytes. This effect is blocked by the KDM6B inhibitor GSK-J4. ChIP (AURKA and YY1 at KDM6B promoter), alisertib treatment, flow cytometry for differentiation markers, KDM6B inhibitor epistasis Molecules and cells Medium 29477140
2018 AURKA promotes STAT3 activity through regulation of JAK2; pharmacological AURKA inhibition (MLN8237) decreases HDM2 protein levels, induces P53 transcriptional activity, and reduces cell survival in vitro and xenograft tumor growth in vivo in gastric cancer models. AURKA inhibitor (alisertib/MLN8237), siRNA, Western blot, xenograft model Clinical cancer research Medium 24240108
2021 AURKA inhibition in Ewing's sarcoma cells induces apoptosis and ferroptosis through the NPM1/YAP1 axis; co-immunoprecipitation confirmed AURKA-NPM1 interaction, and AURKA inhibition disrupts this complex. Co-immunoprecipitation (AURKA-NPM1), pharmacological and siRNA AURKA inhibition, ferroptosis/apoptosis assays, xenograft model Cell death & disease Medium 38287009
2023 HMMR interacts with AURKA and inhibits its ubiquitination-mediated degradation, elevating AURKA protein levels and subsequently activating the mTORC2/AKT pathway to drive prostate cancer progression; E2F1, upregulated by mTORC2/AKT, transcriptionally promotes HMMR expression, forming a positive feedback loop. Co-immunoprecipitation (HMMR-AURKA), ubiquitination assay, gain/loss-of-function experiments, mTOR inhibitor epistasis, in vivo xenograft Cell death discovery Medium 36750558
2021 AURKA promotes psoriasis-related inflammation by blocking autophagy-mediated suppression of the AIM2 inflammasome, acting through activation of the AKT/mTOR pathway; AURKA knockdown inhibits AIM2 inflammasome activation and enhances autophagy, while autophagy inhibition (3-MA) attenuates these effects. siRNA knockdown and overexpression, Western blot for inflammasome components (IL-1β, IL-18, caspase-1 p20), autophagy markers, AKT/mTOR phosphorylation assays, pharmacological inhibitors (PI-103, 3-MA) Immunology letters Medium 34710506

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nature genetics 1115 9771714
1997 A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene 419 9174055
2021 Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy. Molecular cancer 415 33451333
2012 Aurora A kinase (AURKA) in normal and pathological cell division. Cellular and molecular life sciences : CMLS 366 22864622
2003 Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 296 12631597
2003 Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 268 12684414
1997 Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. The Journal of biological chemistry 236 9153231
2000 The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation. Oncogene 235 11039908
2013 Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia (New York, N.Y.) 209 23358695
2001 Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers. International journal of cancer 209 11291073
1995 Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. The Journal of biological chemistry 205 7559596
2001 Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation. British journal of cancer 194 11259099
1992 The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 177 1403099
2001 Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. The Journal of biological chemistry 170 11551964
2016 Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nature communications 159 26782714
2001 The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. Journal of cell science 120 11792803
2018 Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. Nature communications 116 30097580
2005 The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 108 15756006
2003 The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. EMBO reports 98 12634840
2019 Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. Scientific reports 97 31740746
2015 Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly. Frontiers in oncology 82 26779436
2002 The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis. Molecular biology of the cell 76 11950927
2018 Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nature chemical biology 69 29942081
2016 Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression. Oncotarget 68 27329586
2014 AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Molecular oncology 67 24953013
2014 p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. Molecular cancer research : MCR 66 25512615
2004 Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. International journal of oncology 64 15547700
2013 HDM2 regulation by AURKA promotes cell survival in gastric cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 60 24240108
2003 Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 60 14693746
1996 Mitochondrial DNA in migraine with aura. Neurology 60 8649580
1999 Cdc20 associates with the kinase aurora2/Aik. Proceedings of the National Academy of Sciences of the United States of America 59 10377410
2003 Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non-Hodgkin's lymphoma. British journal of haematology 56 12716366
2015 Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia : an international journal of headache 55 26660531
2007 The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 53 17317845
2011 Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. Journal of cell science 49 21540296
2017 The expression of AURKA is androgen regulated in castration-resistant prostate cancer. Scientific reports 47 29269934
2005 Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncology research 44 15839305
2018 Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. Scientific reports 43 29760449
2017 miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA. Biochemical and biophysical research communications 43 28242198
2005 Amplification and overexpression of aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells. Molecular carcinogenesis 42 15880741
1993 Molecular cloning and complete nucleotide sequence of genomic RNA of the AIK-C strain of attenuated measles virus. Virus genes 42 8470368
2021 Tanshinone IIA suppresses the progression of lung adenocarcinoma through regulating CCNA2-CDK2 complex and AURKA/PLK1 pathway. Scientific reports 38 34880385
2018 Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma. Neoplasia (New York, N.Y.) 38 30153557
2021 Repression of the AURKA-CXCL5 axis induces autophagic cell death and promotes radiosensitivity in non-small-cell lung cancer. Cancer letters 37 33848520
2020 Genetics of migraine aura: an update. The journal of headache and pain 36 32503413
2022 A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 35 35652200
2021 ARID3A promotes the development of colorectal cancer by upregulating AURKA. Carcinogenesis 35 33165575
2018 Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. International journal of medical sciences 35 29333101
2018 PRL-3 Promotes Ubiquitination and Degradation of AURKA and Colorectal Cancer Progression via Dephosphorylation of FZR1. Cancer research 35 30498084
2021 The long-noncoding RNA SOCS2-AS1 suppresses endometrial cancer progression by regulating AURKA degradation. Cell death & disease 34 33824269
2017 TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae. Molecular and cellular biology 33 28069741
2019 CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. EMBO reports 32 31885126
1999 Cell-mediated and antibody immune responses to AIK-C and Connaught monovalent measles vaccine given to 6 month old infants. Vaccine 32 10217589
2019 Migraine Aura: Pathophysiology, Mimics, and Treatment Options. Seminars in neurology 31 31847045
2022 Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma. European journal of medicinal chemistry 29 36549117
2024 Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis. Redox biology 28 38642502
2023 Calcitonin gene-related peptide causes migraine aura. The journal of headache and pain 28 37679723
2022 CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine. Frontiers in endocrinology 28 36601001
2020 PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer. Frontiers in oncology 27 33117697
2019 Linc00299/miR-490-3p/AURKA axis regulates cell growth and migration in atherosclerosis. Heart and vessels 25 30734057
2023 HMMR promotes prostate cancer proliferation and metastasis via AURKA/mTORC2/E2F1 positive feedback loop. Cell death discovery 24 36750558
2021 AURKA facilitates the psoriasis-related inflammation by impeding autophagy-mediated AIM2 inflammasome suppression. Immunology letters 24 34710506
1998 Mitochondrial DNA in stroke and migraine with aura. Cerebrovascular diseases (Basel, Switzerland) 24 9548008
2021 LINC00958 promotes bladder cancer carcinogenesis by targeting miR-490-3p and AURKA. BMC cancer 23 34702201
2021 Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress. Cellular oncology (Dordrecht, Netherlands) 22 34176092
2024 AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis. Cell death & disease 21 38287009
2023 The feedback loop of AURKA/DDX5/TMEM147-AS1/let-7 drives lipophagy to induce cisplatin resistance in epithelial ovarian cancer. Cancer letters 21 37217070
2021 RNA-binding protein YBX1 promotes cell proliferation and invasiveness of nasopharyngeal carcinoma cells via binding to AURKA mRNA. Journal of Cancer 21 33976741
2023 Aurora kinase A/AURKA functionally interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death. Cell death discovery 20 37386025
2023 Abnormal Glutamatergic and Serotonergic Connectivity in Visual Snow Syndrome and Migraine with Aura. Annals of neurology 20 37466404
2002 Dopamine receptor genes and migraine with and without aura: an association study. Headache 20 12047334
2024 Contribution of AurkA/TPX2 Overexpression to Chromosomal Imbalances and Cancer. Cells 19 39195284
2020 Molecular Interplay between AURKA and SPOP Dictates CRPC Pathogenesis via Androgen Receptor. Cancers 19 33158056
2022 AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma. iScience 18 35637734
2020 CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes. Reproduction (Cambridge, England) 18 31895686
2018 The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population. Frontiers in physiology 18 30174615
2023 The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia. Molecular medicine (Cambridge, Mass.) 17 36977984
2023 Structural basis for CEP192-mediated regulation of centrosomal AURKA. Science advances 17 37083534
2020 Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer. International journal of molecular sciences 17 33167327
2018 AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway. Molecules and cells 17 29477140
2014 SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner. Molecular cancer research : MCR 17 25061104
2014 Genetic variation in cell cycle regulatory gene AURKA and association with intrinsic breast cancer subtype. Molecular carcinogenesis 17 25328151
2023 CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescence. International journal of biological sciences 16 36778123
2023 AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life science alliance 16 36797043
2022 Stabilization of AURKA by the E3 ubiquitin ligase CBLC in lung adenocarcinoma. Oncogene 16 35149839
2024 Research progress on the relationship between AURKA and tumorigenesis: the neglected nuclear function of AURKA. Annals of medicine 15 38738386
2024 Securinine inhibits carcinogenesis in gastric cancer by targeting AURKA-β-catenin/Akt/STAT3 and the cell cycle pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 15 38810557
2021 Knockdown of AURKA sensitizes the efficacy of radiation in human colorectal cancer. Life sciences 15 33545203
2019 Comparing migraine with and without aura to healthy controls using RNA sequencing. Cephalalgia : an international journal of headache 15 31104508
2017 Recognizing CADASIL: a Secondary Cause of Migraine with Aura. Current pain and headache reports 15 28281108
2017 Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Molecular cancer research : MCR 15 28442587
2023 USP21 contributes to the aggressiveness of laryngeal cancer cells by deubiquitinating and stabilizing AURKA. The Kaohsiung journal of medical sciences 14 36919585
2023 STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer. Journal of translational medicine 14 37101292
2021 Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse. Biology of reproduction 14 34518881
2022 Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations. Medical oncology (Northwood, London, England) 13 36071247
2017 Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform. Scientific reports 13 28592839
2008 AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma. Cell cycle (Georgetown, Tex.) 13 19001879
2007 Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 13 17673924
2024 Targeting AURKA with multifunctional nanoparticles in CRPC therapy. Journal of nanobiotechnology 12 39734237
2023 Neurokinin-1 receptor drives PKCɑ-AURKA/N-Myc signaling to facilitate the neuroendocrine progression of prostate cancer. Cell death & disease 11 37385990

Missed literature

Know a paper Affinage missed for AURKA? Flag it for the maintainers and the community.

No submissions yet.