Affinage

Showing ACTR2 — ARP2 is a alias.

ACTR2

Actin-related protein 2 · UniProt P61160

Length
394 aa
Mass
44.8 kDa
Annotated
2026-06-09
59 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ACTR2 (ARP2) is a core subunit of the ARP2/3 complex that nucleates branched actin networks underlying cell migration, adhesion, and membrane protrusion (PMID:27791462, PMID:41968673). Its actin-organizing output is tuned by opposing post-translational inputs: PTENε physically associates with and dephosphorylates ACTR2 to restrain filopodia formation and tumor cell metastasis (PMID:33755220), whereas a PLK4-CEP85-STIL module drives ACTR2 phosphorylation at the leading edge to support directional migration (PMID:32107292). ACTR2 abundance is controlled at multiple levels — YAP/TAZ mechanotransduction directly activates ACTR2 transcription to build the peri-nuclear actin cap and preserve nuclear envelope integrity, thereby restraining cGAS-STING-driven senescence (PMID:35768505), while a KLF5/ITCH axis targets ACTR2 for ubiquitin-dependent degradation to limit excessive autophagy and injury in podocytes (PMID:41062301). ACTR2-nucleated actin networks are integral to focal adhesion dynamics downstream of the nuclear lamina (PMID:27791462) and to branched-actin-dependent autophagosome assembly (PMID:41968673). Beyond its cytoskeletal role, ACTR2 was originally characterized as a kinase-independent component of a high-affinity heterotrimeric activin receptor complex on endothelial cells (PMID:8307945), and its function is co-opted in disease, serving as a binding partner of rotavirus VP4 to promote viral replication (PMID:37991368) and acting downstream of CRLF3 to promote hepatocellular carcinoma immune escape (PMID:40469577). Actr2 haploinsufficiency is lethal in mice, underscoring its essentiality (PMID:28827327).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1994 High

    Established ACTR2's earliest molecular identity by showing it participates in a high-affinity activin receptor complex independent of its kinase domain, defining a non-catalytic mode of complex assembly.

    Evidence 125I-activin-A affinity labeling and reciprocal immunoprecipitation with full-length and kinase-dead ACTR2 constructs in bovine aortic endothelial cells

    PMID:8307945

    Open questions at the time
    • Does not connect this receptor role to the later-defined ARP2/3 actin-nucleation function
    • Downstream signaling consequences not resolved
  2. 2016 Medium

    Placed ACTR2 downstream of nuclear lamina integrity, linking ARP2/3-dependent actin assembly to focal adhesion size and cell motility control.

    Evidence LMNA siRNA knockdown with quantitative proteomics, focal adhesion immunofluorescence, traction force microscopy, and ARP2/3 chemical inhibitor rescue

    PMID:27791462

    Open questions at the time
    • Mechanism linking lamina loss to ARP2/3 subunit reduction unresolved
    • ACTR2-specific contribution not separated from the whole complex
  3. 2017 Medium

    Demonstrated ACTR2 essentiality and a role in thrombosis regulation via genetic epistasis, distinguishing a hypomorphic/gain-of-function point allele from lethal haploinsufficiency.

    Evidence ENU mutagenesis screen with whole-exome sequencing and independent CRISPR/Cas9 alleles in Factor V Leiden/Tfpi mice

    PMID:28827327

    Open questions at the time
    • Molecular mechanism by which p.R258G suppresses thrombosis unknown
    • Cellular pathway connecting ACTR2 to coagulation not defined
  4. 2020 Medium

    Identified a kinase-driven activating input on ACTR2 by showing PLK4-recruited CEP85/STIL promote ACTR2 phosphorylation needed for directional migration.

    Evidence siRNA knockdown of CEP85/STIL with ACTR2 phosphorylation assays, live-cell migration assays, and interaction mutagenesis

    PMID:32107292

    Open questions at the time
    • Phosphorylation site on ACTR2 not mapped
    • Whether PLK4 directly phosphorylates ACTR2 not established
  5. 2021 High

    Defined an opposing dephosphorylation input, showing PTENε directly dephosphorylates ACTR2 to restrain filopodia formation and metastasis.

    Evidence Co-immunoprecipitation, in vitro dephosphorylation assay, and loss-of-function with filopodia and metastasis readouts

    PMID:33755220

    Open questions at the time
    • Phospho-residues controlled by PTENε not identified
    • Interplay with the PLK4/CEP85/STIL phosphorylation axis untested
  6. 2022 Medium

    Connected ACTR2 transcriptional control to nuclear mechanics, showing YAP/TAZ directly drives ACTR2 expression to maintain the peri-nuclear actin cap and suppress cGAS-STING senescence.

    Evidence Genetic YAP/TAZ inactivation, transcriptional reporter and ChIP for direct ACTR2 regulation, nuclear envelope integrity assays, STING inhibition rescue

    PMID:35768505

    Open questions at the time
    • Whether actin cap defect is solely ACTR2-dependent not isolated
    • Quantitative contribution of ACTR2 versus other YAP/TAZ targets unclear
  7. 2023 Medium

    Revealed pathogen co-option of ACTR2, identifying it as a VP4-binding partner required for rotavirus replication.

    Evidence BioID proximity labeling, siRNA knockdown, antibody blocking, recombinant protein overexpression, and viral binding assays

    PMID:37991368

    Open questions at the time
    • Step of viral life cycle requiring ACTR2 (entry vs replication) not fully resolved
    • Whether ARP2/3 actin nucleation mediates the effect untested
  8. 2024 Medium

    Extended ACTR2's reach to meiotic spindle dynamics, placing it downstream of PLD1 in regulating MTOC clustering and asymmetric spindle positioning.

    Evidence PLD1 inhibition with ACTR2 overexpression rescue, spindle/MTOC immunofluorescence, and PLD1-ACTR2 proximity ligation in mouse oocytes

    PMID:38513669

    Open questions at the time
    • Whether PLD1-ACTR2 association is direct not established
    • Mechanism by which PLD1 maintains ACTR2 levels unclear
  9. 2025 Medium

    Defined a degradative control axis, showing KLF5-induced ITCH ubiquitinates ACTR2 to limit ACTR2-driven autophagy and podocyte injury.

    Evidence Co-IP, ChIP, dual-luciferase reporter, knockdown/overexpression, autophagy and apoptosis assays, ADR rat model

    PMID:41062301

    Open questions at the time
    • Ubiquitination sites on ACTR2 not mapped
    • How ACTR2 promotes autophagy mechanistically not defined
  10. 2025 Medium

    Implicated ACTR2 in tumor immune evasion, showing CRLF3 binds ACTR2 to suppress CD8+ T cell effector function in hepatocellular carcinoma.

    Evidence Co-immunoprecipitation, CRLF3 knockdown with ACTR2 overexpression rescue, proliferation/migration assays, flow cytometry, and xenografts

    PMID:40469577

    Open questions at the time
    • Mechanism linking ACTR2 to immune escape signaling not defined
    • Whether actin nucleation is required for immune effect untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the competing phosphorylation, dephosphorylation, transcriptional, and ubiquitin-degradation inputs are integrated to set ACTR2 activity in a given cellular context remains unresolved.
  • No unified model of ACTR2 regulatory hierarchy
  • Phospho-sites and ubiquitination sites remain unmapped
  • Structural basis of regulation within the ARP2/3 complex not addressed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2
Partners
ACTR3CEP85CORO1CCRLF3ITCHPTENΕSTILWASF3
Complex memberships
ARP2/3 complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 ACTR2 (type 2 activin receptor) forms a high-affinity heterotrimeric receptor complex on vascular endothelial cell surfaces with activin-binding proteins characteristic of type 1 and type 3 activin receptors. Complex formation does not require the kinase domain of ACTR2. Two classes of 125I-activin-A binding sites were identified: high affinity (Kd ~250 pM) and low affinity (Kd ~6.5–16 nM). Affinity labeling revealed labeled species of 55, 95, 100, and 160 kDa, all immunoprecipitated by anti-ACTR2 antibody. 125I-activin-A affinity labeling, immunoprecipitation with anti-ACTR2 monoclonal antibody, transfection of full-length and kinase-dead truncated ACTR2 constructs in bovine aortic endothelial cells The Journal of biological chemistry High 8307945
2021 PTENε (PTEN5), a novel N-terminal-extended PTEN isoform, physically associates with and dephosphorylates ACTR2, governing filopodia formation and cell motility. Endogenous depletion of PTENε promotes filopodia formation and enhances metastasis of tumor cells. Co-immunoprecipitation, phosphatase assay (in vitro dephosphorylation of ACTR2), loss-of-function with filopodia and metastasis phenotypic readouts The EMBO journal High 33755220
2020 PLK4 drives recruitment of CEP85 and STIL to the leading edge of migrating cells, and downregulation of CEP85 and STIL leads to reduced ARP2 (ACTR2) phosphorylation and reorganization of the actin cytoskeleton, impairing directional cell migration. siRNA knockdown of CEP85/STIL, phosphorylation assay for ACTR2, live-cell migration assays, mutational analysis of CEP85-STIL-PLK4 interactions Journal of cell science Medium 32107292
2022 YAP/TAZ mechanotransduction directly transcriptionally regulates ACTR2, which is involved in building the peri-nuclear actin cap; loss of YAP/TAZ reduces ACTR2 expression, compromises nuclear envelope integrity, and unleashes cGAS-STING signaling leading to tissue senescence. Genetic inactivation of YAP/TAZ in stromal cells, transcriptional reporter and ChIP assays for direct regulation of ACTR2, nuclear envelope integrity assays, STING inhibition rescue experiments Nature Medium 35768505
2017 An Actr2 point mutation (p.R258G) identified in a sensitized ENU mutagenesis screen is associated with suppression of lethal thrombosis in Factor V Leiden/Tfpi haploinsufficient mice, suggesting ACTR2 plays a role in thrombosis regulation. Actr2 haploinsufficiency is lethal, supporting a hypomorphic or gain-of-function mechanism for the p.R258G variant. ENU mutagenesis screen, whole-exome sequencing, CRISPR/Cas9 knockin/knockout to generate independent Actr2 alleles, genetic epistasis analysis Proceedings of the National Academy of Sciences of the United States of America Medium 28827327
2016 Loss of A-type lamins (LMNA knockdown) leads to reduced levels of ACTR2/3 (ARP2/3 complex subunits), reduced focal adhesion size, decreased early cell adhesion, and increased cell motility. Chemical inhibition of the ARP2/3 complex partly recapitulates the lamin-loss phenotype, placing ACTR2 downstream of nuclear lamina integrity in regulating focal adhesion dynamics. siRNA-mediated LMNA knockdown, quantitative stable isotope labeling-based shotgun proteomics, quantitative immunofluorescence of focal adhesions, traction force microscopy, ARP2/3 complex chemical inhibition Cell adhesion & migration Medium 27791462
2023 ACTR2 (ARP2) is a cellular binding partner of rotavirus VP4 that promotes viral replication in intestinal cells. Knockdown of ACTR2 reduced RV replication, antibody blocking and recombinant protein overexpression further confirmed that ACTR2 promotes RV entry/replication. Proximity labeling (BioID), siRNA knockdown, antibody blocking, recombinant protein overexpression, viral binding assays Journal of virology Medium 37991368
2024 In mouse oocyte meiosis, PLD1 maintains ACTR2 levels and local distribution on MTOC, spindle, and vesicles; overexpression of ACTR2 rescues MTOC clustering, spindle assembly, and asymmetric spindle positioning in PLD1-depleted oocytes, placing ACTR2 downstream of PLD1 in regulating meiotic spindle dynamics. PLD1 genetic/chemical inhibition, overexpression of ACTR2 in PLD1-depleted oocytes, immunofluorescence for spindle and MTOC markers, proximity ligation assay for PLD1-ACTR2 interaction Autophagy Medium 38513669
2025 CRLF3 physically binds ACTR2 (demonstrated by co-immunoprecipitation) and this interaction promotes proliferation, migration, and immune escape of hepatocellular carcinoma cells. Knockdown of CRLF3 increased CD8+ T cell effector function, and overexpression of ACTR2 reversed this effect, indicating CRLF3 acts through ACTR2 to suppress anti-tumor immunity. Co-immunoprecipitation, siRNA knockdown of CRLF3 and overexpression of ACTR2, MTT/colony assays, Transwell migration/invasion assays, flow cytometry for CD8+ T cell markers, xenograft mouse model Cytotechnology Medium 40469577
2025 KLF5 promotes ITCH transcription, and ITCH-mediated ubiquitination of ACTR2 leads to its degradation. KLF5 overexpression attenuates ACTR2-driven autophagy, apoptosis, and inflammation in adriamycin-injured podocytes. ACTR2 silencing reverses ADR-induced apoptosis and reduces autophagy markers, demonstrating ACTR2 as a promoter of excessive autophagy and podocyte injury downstream of the KLF5/ITCH axis. Co-immunoprecipitation, chromatin immunoprecipitation (ChIP), dual luciferase reporter assay, siRNA knockdown and overexpression, Western blot for autophagy markers, flow cytometry for apoptosis, ADR rat model The Tohoku journal of experimental medicine Medium 41062301
2022 ACTR2 knockdown inhibits malignant behaviors of diffuse large B-cell lymphoma (DLBCL) cells, while ACTR2 overexpression promotes them. ACTR2 activates Wnt signaling in DLBCL, and its oncogenic influence is mediated through this pathway, confirmed in vitro and in vivo. siRNA knockdown and overexpression of ACTR2 in DLBCL cell lines, Wnt pathway reporter assays, xenograft mouse model Computational and mathematical methods in medicine Low 36570337
2016 PKD2 (protein kinase D2) physically interacts with the entire seven-subunit Arp2/3 complex including ACTR2 and ACTR3, as identified by chemical cross-linking/mass spectrometry from Golgi-enriched subcellular fractions, providing evidence of a direct PKD2–Arp2/3 protein-protein interaction. Affinity enrichment, chemical cross-linking/mass spectrometry from cytosolic and Golgi-enriched subcellular fractions Journal of proteome research Low 27559607
2024 In bladder cancer, ACTR2/ARP2 is upregulated and forms part of the CTTN-ARP2 axis driving lamellipodia formation; sulforaphane (SFN) causes lamellipodia collapse by blocking the CTTN-ARP2 axis and downregulating ACTR2/ARP2 expression, suppressing bladder cancer metastasis in vivo. Overexpression of AKT1, cell morphology assays, bioluminescent imaging of lung metastases in nude mice, Western blot and qPCR for CTTN and ARP2 Cancer letters Low 39084455
2024 In anal fistula wound healing, IL-6+ macrophages promote WASF3 expression in fibroblasts which recruits ACTR2 (ARP2), facilitating fibroblast migration via JAK2/STAT3 signaling; this intercellular communication is modulated by Calvatia lilacina treatment. Single-cell RNA sequencing, cell co-culture, immunofluorescence, Western blot, flow cytometry Chinese medicine Low 41495793
2024 CORO1C interacts with ACTR2/ARP2-ACTR3/ARP3 complex; this interaction is essential for branched actin network assembly, SQSTM1/p62 body formation, and autophagosome structural integrity in mammalian cells. Genome-wide loss-of-function screen, Co-immunoprecipitation, autophagy assays, electron microscopy, coro1c knockout mice Autophagy Low 41968673
2024 GJA1/Cx43 promotes exocytosis of damaged lysosomes through a mechanism that relies on ACTR2/ARP2-ACTR3/ARP3-dependent actin remodeling. Live imaging, siRNA knockdown, lysosomal damage assays, actin remodeling assays Autophagy Low 39394955
2022 Nuclear BRAFV600E interacts with Arp2/3 complex members including ACTR2 (ARP2) as identified by proteomic analysis; this nuclear interaction is associated with aggressive phenotypes and vemurafenib resistance in papillary thyroid cancer. Nuclear localization signal (NLS) BRAFV600E constructs, proteomic analysis of nuclear BRAFV600E binding partners, xenograft mouse model, IHC of PTC specimens American journal of cancer research Low 35968344

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Nature 232 35768505
2014 Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell stem cell 199 24996170
2023 Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. European heart journal 102 37038246
2022 CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial-mesenchymal transition of renal tubular epithelial cells. Cellular and molecular life sciences : CMLS 46 35449370
2020 A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine. Genetics, selection, evolution : GSE 44 33292187
2018 ATG5 is required for B cell polarization and presentation of particulate antigens. Autophagy 42 30196744
2013 CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity. Oncogene 42 23644663
2021 Proteomic Profiling of Exosomes From Hemorrhagic Moyamoya Disease and Dysfunction of Mitochondria in Endothelial Cells. Stroke 38 34334053
2015 Genome-wide analysis identifies a role for common copy number variants in specific language impairment. European journal of human genetics : EJHG 36 25585696
2022 Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing. Frontiers in immunology 35 36439123
2009 Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 34 19617259
2023 Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA. Frontiers in immunology 32 37691920
2021 Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy. Diabetology & metabolic syndrome 28 34174955
2021 PTENε suppresses tumor metastasis through regulation of filopodia formation. The EMBO journal 27 33755220
1994 Activin-A binds to a heterotrimeric receptor complex on the vascular endothelial cell surface. Evidence for a type 3 activin receptor. The Journal of biological chemistry 20 8307945
2023 Analysis of mRNA-miRNA interaction network reveals the role of CAFs-derived exosomes in the immune regulation of oral squamous cell carcinoma. BMC cancer 19 37365497
2016 Deregulation of focal adhesion formation and cytoskeletal tension due to loss of A-type lamins. Cell adhesion & migration 19 27791462
2004 Confirmation of linkage and refinement of the RP28 locus for autosomal recessive retinitis pigmentosa on chromosome 2p14-p15 in an Indian family. Molecular vision 19 15215745
2022 Circular RNA ACTR2 activates M2 polarization of macrophages through activating Yes-associated protein signalling and contributes to renal fibrosis. Immunology 17 36069177
2019 Peptides derived from the extracellular domain of the somatostatin receptor splicing variant SST5TMD4 increase malignancy in multiple cancer cell types. Translational research : the journal of laboratory and clinical medicine 17 30904441
2020 Differential expression of BMP/SMAD signaling and ovarian-associated genes in the granulosa cells of FecB introgressed GMM sheep. Systems biology in reproductive medicine 16 31957496
2012 Screening of candidate genes for primary open angle glaucoma. Molecular vision 16 22876139
2020 Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration. Journal of cell science 13 32107292
2017 Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proceedings of the National Academy of Sciences of the United States of America 12 28827327
2016 Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-Linking/Mass Spectrometry. Journal of proteome research 11 27559607
2024 PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis. Autophagy 10 38513669
2022 Novel Insights into the Stemness and Immune Privilege of Mesenchymal Stem Cells from Human Wharton Jelly by Single-Cell RNA Sequencing. Medical science monitor : international medical journal of experimental and clinical research 10 35153292
2024 Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation. Cancer letters 9 39084455
2023 Identification of immune-associated signatures and potential therapeutic targets for pulmonary arterial hypertension. Journal of cellular and molecular medicine 9 37753829
2023 CD45 inhibition in myeloid leukaemia cells sensitizes cellular responsiveness to chemotherapy. Annals of hematology 8 37917373
2015 The segregation of different submicroscopic imbalances underlying the clinical variability associated with a familial karyotypically balanced translocation. Molecular cytogenetics 8 26719771
2023 Interaction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay. Journal of virology 7 37991368
2023 Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis. American journal of human genetics 6 36924774
2021 RBBP4 Enhances Platinum Chemo Resistance in Lung Adenocarcinoma. BioMed research international 6 33506032
2022 Upregulation of Actin-Related Protein 2 (ACTR2) Exacerbated the Malignancy of Diffuse Large B-Cell Lymphoma through Activating Wnt Signaling. Computational and mathematical methods in medicine 5 36570337
2025 Single-cell proteomics analysis of human oocytes during GV-to-MI transition. Human reproduction (Oxford, England) 4 40359387
2025 Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC. Scientific reports 4 40629035
2025 Conserved Blood Transcriptome Patterns Highlight microRNA and Hub Gene Drivers of Neurodegeneration. Genes 4 41153395
2024 Identification and RT-qPCR Validation of Biomarkers Based on Butyrate Metabolism-Related Genes to Predict Recurrent Miscarriage. Journal of inflammation research 4 39372587
2022 Bioinformatic Data Mining for Candidate Drugs Affecting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) in Cancer Patients. Disease markers 4 36157219
2017 Clinical and molecular cytogenetic characterization of four unrelated patients carrying 2p14 microdeletions. American journal of medical genetics. Part A 3 28599093
2012 Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours. Journal of comparative pathology 3 22935087
2026 Single-cell RNA sequencing reveals the therapeutic mechanism of Calvatia lilacina in promoting wound healing of anal fistula. Chinese medicine 1 41495793
2026 Single-cell transcriptomics and machine-learning reveal M1 macrophage-driven progression from minimal change disease to focal segmental glomerulosclerosis. Renal failure 1 41622775
2022 A familial 2p14 microdeletion disrupting actin-related protein 2 and Ras-related protein Rab-1A genes with intellectual disability and language impairment. European journal of medical genetics 1 35134569
2022 Nuclear interaction of Arp2/3 complex and BRAFV600E promotes aggressive behavior and vemurafenib resistance of thyroid cancer. American journal of cancer research 1 35968344
2021 RNA-seq and nuclear proteomics provide insights into the lactation regulation mechanism of goat transfected IGF-I and GH recombinant vectors. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1 34507252
2026 Proteomic Profiling of PTEN Inhibition on Periodontal Ligament Stem Cells. International dental journal 0 41863976
2026 ARPC2 Promotes Pulmonary Fibrosis by Regulating MRTFA Activity Independent of the Canonical ARP2/3 Complex. International journal of molecular sciences 0 41898590
2026 CORO1C (coronin 1C) promotes autophagosome formation by coordinating branched actin network dynamics. Autophagy 0 41968673
2026 Machine Learning-Based Classification of Gliomas and Tumor Grades with SHAP-Guided Feature Interpretation. Genes 0 42194968
2025 Mechanisms of CRLF3-targeted binding to ACTR2 to promote hepatocellular carcinoma progression and effects on the immune microenvironment. Cytotechnology 0 40469577
2025 In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension. PloS one 0 40720495
2025 KLF5 Alleviates Excessive Autophagy-Induced Podocyte Injury by Enhancing ITCH-Mediated Ubiquitination of ACTR2. The Tohoku journal of experimental medicine 0 41062301
2025 Transcriptomic analysis reveals impaired tight junction and upregulated IL-17 signaling in induced abnormal keratinization area of rumen. Journal of animal science 0 41092026
2025 Mesenchymal stem cells reverse disease-specific abnormalities in nociceptive regions of the brain. Brain communications 0 41509715
2024 Screening for the presence of aberrantly expressed ACTR2 in osteosarcoma and analyzing its mechanism of action through an online database. American journal of cancer research 0 39267681
2024 Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged lysosomes to the cell periphery to potentiate exocytosis. Autophagy 0 39394955
1994 Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 0 7927363

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