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Showing ADPRH — ARH1 is a alias.

ADPRH

ADP-ribosylhydrolase ARH1 · UniProt P54922

Length
357 aa
Mass
39.5 kDa
Annotated
2026-06-09
66 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ADPRH (ARH1) is a cytosolic, ubiquitously expressed enzyme that reverses arginine-specific mono-ADP-ribosylation by hydrolyzing the N-glycosidic ADP-ribose–arginine bond on modified proteins, regenerating unmodified protein and releasing free ADP-ribose (PMID:16278211, PMID:36497109). Catalysis requires vicinal acidic active-site residues and is enhanced by Mg2+, with crystallographic analysis showing that ARH1 binds K+ as a structural ion and that its adenosine-ribose binding diverges from the related ARH3 to dictate distinct substrate specificity (PMID:16278211, PMID:19407395, PMID:30472116). Beyond protein substrates, ARH1 hydrolyzes O-acetyl-ADP-ribose via nucleophilic attack at the C-1″ position and stereospecifically cleaves α-NAD+ but not β-NAD+, linking it to broader NAD+ metabolism (PMID:21498885, PMID:31599159). ARH1 operates as the eraser in an ADP-ribosylation cycle whose writers are bacterial cholera toxin and the cellular transferase ARTC1/ART1: it counteracts cholera toxin-mediated ADP-ribosylation of Gαs, with ARH1-deficient mice showing greater intoxication and fluid accumulation, and it cleaves ADP-ribosylated TRIM72 in myocardium, where ARH1, ART1, and TRIM72 form co-immunoprecipitating complexes (PMID:17526733, PMID:30429362, PMID:36497109). Loss of ARH1 produces distinct pathologies across these axes: cardiomyopathy with myocardial fibrosis, impaired membrane repair, and increased ischemia/reperfusion injury (PMID:30429362), and tumorigenesis—ARH1 acts as a tumor suppressor, with knockout/heterozygous mice developing lymphomas and adenocarcinomas, loss of heterozygosity in tumors, and tumorigenicity that scales inversely with retained hydrolase activity, placing ARTC1 as the epistatic writer counterpart in this cancer pathway (PMID:21697277, PMID:26029825, PMID:36945646).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2005 High

    Establishing that ARH1 is an enzyme reversing arginine ADP-ribosylation answered what biochemical activity the gene encodes and defined its catalytic requirements.

    Evidence In vitro enzymatic assay with recombinant protein, active-site mutagenesis, and substrate specificity analysis

    PMID:16278211

    Open questions at the time
    • Did not establish in vivo physiological substrates
    • Structural basis of catalysis not yet resolved
  2. 2009 Medium

    Crystallization with K+ and ADP provided the first high-resolution structural view and revealed a structural role for K+ in the enzyme.

    Evidence X-ray crystallography at 1.9 Å with X-ray fluorescence analysis of recombinant protein

    PMID:19407395

    Open questions at the time
    • No functional mutagenesis follow-up on K+ site
    • Substrate-bound conformation not captured
  3. 2007 High

    Demonstrating that ARH1 counteracts cholera toxin ADP-ribosylation of Gαs in vivo connected the in vitro activity to a physiological host-defense role against bacterial toxin.

    Evidence ADPRH-knockout mouse model with overexpression rescue, ADP-ribosylarginine and Gαs quantification, intestinal loop fluid assay

    PMID:17526733

    Open questions at the time
    • Did not address endogenous (non-toxin) substrates
    • Tissue-specific contributions not dissected
  4. 2011 High

    Identifying ARH1 as a tumor suppressor whose loss drives spontaneous tumors and LOH established a cancer-relevant function beyond toxin defense.

    Evidence Knockout/heterozygous mouse tumor incidence, MEF proliferation, nude mouse xenograft, loss-of-heterozygosity analysis

    PMID:21697277

    Open questions at the time
    • Endogenous substrate driving transformation not identified
    • Mechanism linking ADP-ribose accumulation to proliferation unresolved
  5. 2011 High

    Showing ARH1 hydrolyzes O-acetyl-ADP-ribose and poly(ADP-ribose) broadened its substrate range and defined the reaction chemistry at the C-1″ position.

    Evidence In vitro assays with pH dependence, H218O isotope labeling/mass spectrometry, and IC50 with ADP-ribose analogues

    PMID:21498885

    Open questions at the time
    • Physiological relevance of OAADPr/PAR hydrolysis in cells not established
    • Relative in vivo flux through each substrate unknown
  6. 2015 High

    Correlating graded hydrolase activity loss in tumor-derived ARH1 mutants with tumorigenicity established that catalytic activity is directly responsible for tumor suppression.

    Evidence Enzymatic assays of mutant proteins, MEF transformation, soft-agar colony assay, nude mouse xenograft

    PMID:26029825

    Open questions at the time
    • Specific ADP-ribosylated target mediating suppression not pinned down
    • Signaling pathway downstream of substrate accumulation unknown
  7. 2018 High

    Identifying TRIM72 as a cardiac substrate and showing cardiomyopathy in ARH1-deficient mice extended the eraser function to membrane repair physiology.

    Evidence Knockout mouse cardiac phenotyping, co-immunoprecipitation of ARH1/ART1/TRIM72 complexes, C2C12 knockdown scratch-wound assay, mutant TRIM72 analysis

    PMID:30429362

    Open questions at the time
    • How TRIM72 ADP-ribosylation impairs membrane repair mechanistically not fully defined
    • Whether other cardiac substrates contribute unknown
  8. 2018 Medium

    Revealing greater cholera toxin sensitivity in female ARH1-KO mice introduced a sex-dependent dimension to ARH1 toxin regulation.

    Evidence Knockout mouse intestinal loop assay with ADP-ribosylarginine and Gαs quantification comparing male and female mice

    PMID:30500844

    Open questions at the time
    • Molecular basis of sex difference not identified
    • Single lab, biochemical readouts only
  9. 2019 High

    Demonstrating stereospecific α-NAD+ hydrolysis positioned ARH1 within cellular NAD+ metabolism alongside ARH3 and macrodomains.

    Evidence In vitro enzymatic assays with recombinant enzymes comparing α- vs β-NAD+, supported by structural data

    PMID:31599159

    Open questions at the time
    • In vivo contribution to NAD+ pools not quantified
    • Cellular source of α-NAD+ substrate unclear
  10. 2018 High

    Comparative crystallography of ARH1 and ARH3 explained their divergent substrate specificity and the selective inhibition of ARH3.

    Evidence X-ray crystallography with biochemical inhibition assays using ADP-HPD and arginine-ADP-ribose

    PMID:30472116

    Open questions at the time
    • No selective ARH1 inhibitor defined
    • Catalytic mechanism transitions not directly visualized
  11. 2023 Medium

    Genetic epistasis placing ARTC1 as the writer counterpart to ARH1 closed the loop on the ADP-ribosylation cycle underlying tumorigenesis and revealed immune involvement.

    Evidence Artc1/Arh1 double-KO MEFs, nude mouse xenografts, tumor immunophenotyping (preprint)

    PMID:36945646

    Open questions at the time
    • Preprint not peer-reviewed
    • Shared endogenous substrate of the ARTC1/ARH1 cycle in tumors not defined
    • Mechanism of immune infiltration and necroptosis unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The endogenous protein substrate(s) whose persistent ADP-ribosylation mediates ARH1's tumor-suppressor and metabolic functions remain unidentified.
  • No proteome-wide map of physiological ARH1 substrates in transformation
  • Downstream signaling from substrate accumulation to phenotype not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0140098 catalytic activity, acting on RNA 2
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-1643685 Disease 2 R-HSA-1430728 Metabolism 1
Partners
ART1ARTC1GNASTRIM72

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 ARH1 (ADPRH) is a 39-kDa ADP-ribosylarginine hydrolase that cleaves the N-glycosidic bond of mono-ADP-ribosylated arginine residues on proteins, releasing free ADP-ribose and regenerating unmodified protein. Its activity is enhanced by Mg2+. Critical vicinal acidic amino acids required for catalytic activity were identified by mutagenesis. In vitro enzymatic assay with recombinant protein; mutagenesis of catalytic residues; substrate specificity analysis The Journal of biological chemistry High 16278211
2007 ARH1 (ADPRH) counteracts cholera toxin-mediated ADP-ribosylation of the Gsα protein in vivo. ADPRH-knockout cells and mice showed greater intoxication (higher ADP-ribosylarginine content, greater Gsα modification, increased fluid accumulation in intestinal loops) than wild-type, and overexpression of wild-type ADPRH in knockout cells reduced these effects. ADPRH knockout mouse model; overexpression rescue; measurement of ADP-ribosylarginine content and Gsα modification; intestinal loop fluid accumulation assay Molecular and cellular biology High 17526733
2011 ARH1 deficiency in mice leads to spontaneous development of lymphomas, adenocarcinomas, and metastases, establishing ARH1 as a tumor suppressor. ARH1-null and heterozygous mouse embryonic fibroblasts showed higher proliferation rates and formed tumors in nude mice. Loss of heterozygosity of the remaining ARH1 allele was documented in all tumors from heterozygous mice. ARH1 knockout and heterozygous mouse models; tumor incidence analysis; MEF proliferation assays; nude mouse xenograft; loss-of-heterozygosity analysis Cancer research High 21697277
2014 Comprehensive structural analysis of ARH1 and ARH3 by crystallography revealed that the two enzymes have distinct substrate requirements driven by diverged adenosine ribose moiety binding, while the active sites harboring the distal ribose closely resemble each other. Structural basis for selective inhibition of ARH3 (but not ARH1) by ADP-HPD and arginine-ADP-ribose was elucidated. X-ray crystallography; biochemical inhibition assays with ADP-ribose analogues Cell chemical biology High 30472116
2009 Human ARH1 (ADPRH) was crystallized in complex with K+ and ADP, yielding diffracting crystals at 1.9 Å resolution. The presence of K+ was required for well-diffracting crystals, indicating a structural role for K+ in the enzyme. Recombinant protein expression in E. coli, X-ray crystallography, X-ray fluorescence analysis Acta crystallographica. Section F, Structural biology and crystallization communications Medium 19407395
2018 ARH1 cleaves ADP-ribosylated TRIM72 (tripartite motif-containing protein 72) on arginine residues in the myocardium. ARH1-deficient mice developed cardiomyopathy with myocardial fibrosis, decreased myocardial function, and increased susceptibility to ischemia/reperfusion injury. ARH1, ART1 (the writing enzyme), and TRIM72 were found in multiple co-immunoprecipitated complexes from mouse heart lysates. ARH1 knockdown in C2C12 myocytes increased ADP-ribosylation of TRIM72 and delayed wound healing. ARH1-knockout mouse model; co-immunoprecipitation from heart lysates; ARH1 knockdown in C2C12 myocytes; scratch wound assay; mutant TRIM72 (R207K, R260K) functional analysis JCI insight High 30429362
2015 ARH1 mutations found in tumors from ARH1 heterozygous mice encode proteins with reduced enzymatic activity. MEFs transformed with ARH1 mutant genes showed altered proliferation rates, anchorage-independent colony growth, and tumorigenesis in nude mice in proportion to the degree of hydrolase activity loss, establishing a direct link between ARH1 catalytic activity and tumor suppression. Enzymatic activity assays of ARH1 mutant proteins; MEF transformation; soft-agar colony assay; nude mouse xenograft Oncogenesis High 26029825
2019 ARH1 hydrolyzes α-NAD+ (but not β-NAD+) in a stereospecific reaction, in addition to its established α-ADP-ribosyl-arginine hydrolase activity. This activity is shared with ARH3 and macrodomain proteins, revealing a broader role in cellular NAD+ metabolism. In vitro enzymatic assay with recombinant ARH1, ARH3, and macrodomain proteins; substrate specificity with α-NAD+ vs β-NAD+; crystal structures of Af1521 and ARH3 with bound ADP-ribose ACS chemical biology High 31599159
2011 ARH1 hydrolyzes O-acetyl-ADP-ribose (OAADPr) and poly(ADP-ribose), in addition to ADP-ribose-arginine. Mechanistic analysis revealed that ARH1-catalyzed hydrolysis of OAADPr involves nucleophilic attack at the C-1″ position, consistent with cleavage of a 1″-O linkage. A postulated 1″-OAADPr isomer was identified at alkaline pH. In vitro enzymatic assay; pH-dependence studies; H218O isotope labeling with mass spectrometric analysis; IC50 measurements with ADP-ribose analogues The Journal of biological chemistry High 21498885
2018 Female ARH1-knockout mice show greater sensitivity to cholera toxin than male ARH1-KO mice, with higher ADP-ribosylated Gsα protein levels and increased ADP-ribosylarginine content in intestinal epithelial cells, revealing a gender-dependent role of ARH1 in regulating cholera toxin-mediated ADP-ribosylation. ARH1 knockout mouse model; intestinal loop fluid accumulation assay; measurement of ADP-ribosylarginine content; ADP-ribosyl Gαs level quantification; comparison of male vs female mice PloS one Medium 30500844
2005 The ADPRH (ARH1) gene spans approximately 9 kilobases with four exons and three introns. Promoter analysis identified potent stimulatory (−119 to −89) and inhibitory (−161 to −119) elements. An Sp1-binding GC-box element (−107 to −95) positively regulates ADPRH transcription, as demonstrated by Sp1/Sp3 binding (EMSA) and Sp1 trans-activation in Drosophila SL2 cells lacking endogenous Sp1. Genomic cloning; Northern analysis; transient transfection with truncated promoter constructs; electrophoretic mobility-shift assay (EMSA); supershift assay; co-transfection in Drosophila SL2 cells Gene Medium 15893437
2002 Retroviral expression of wild-type ARH1 in transformed lymphocytes from autosomal recessive hypercholesterolemia patients restored LDL receptor internalization, as demonstrated by uptake and degradation of 125I-labeled LDL and confocal microscopy, establishing ARH1 as a functional adaptor required for LDL receptor-dependent LDL internalization in lymphocytes and macrophages. Retroviral expression of ARH1; 125I-LDL uptake and degradation assay; confocal microscopy The Journal of clinical investigation Medium 12464675
2022 ARH1 is a cytosolic protein ubiquitously expressed in mammalian tissues. In vivo confirmed substrates include Gαs (ADP-ribosylated by cholera toxin) and TRIM72 (ADP-ribosylated by ART1), with ARH1 cleaving the ADP-ribose-arginine bond on these proteins. ARH1 deficiency leads to increased ADP-ribosylation of TRIM72 following ischemia/reperfusion injury. Subcellular fractionation (cytosolic localization); in vivo substrate identification by ARH1-KO mouse studies; proteomic identification of ADP-ribosylarginine substrates Cells Medium 36497109
2023 ARTC1 (the arginine-specific ADP-ribosyltransferase) and ARH1 function in the same ADP-ribosylation cycle. Artc1/Arh1 double-KO MEFs showed decreased tumorigenesis in nude mice compared to Arh1-KO MEFs, and Artc1-KO recipient mice showed decreased xenograft tumor growth with CD8+ T cell and macrophage infiltration and necroptosis, establishing ARTC1 as the writing enzyme counterpart to ARH1 in the same pathway. Double-KO mouse model (Artc1/Arh1); nude mouse xenograft; immunophenotyping of tumor infiltrate; genetic epistasis bioRxivpreprint Medium 36945646

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature 412 8107887
1994 Signal transduction by the B cell antigen receptor and its coreceptors. Annual review of immunology 373 8011288
2005 Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase. The Journal of biological chemistry 248 16278211
1995 TCR/CD3 coupling to Fas-based cytotoxicity. The Journal of experimental medicine 210 7530763
2014 Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin. Nature communications 142 25358379
1994 Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. The EMBO journal 135 8168489
1994 Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proceedings of the National Academy of Sciences of the United States of America 126 8183901
2002 Autosomal recessive hypercholesterolaemia in Sardinia, Italy, and mutations in ARH: a clinical and molecular genetic analysis. Lancet (London, England) 107 11897284
1993 B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Current biology : CB 107 15335855
2006 The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America 105 17075046
1995 Identification of signaling motifs within human Fc gamma RIIa and Fc gamma RIIb isoforms. Blood 100 7718892
2011 Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chemistry & biology 97 21944752
2011 Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants. Biochimica et biophysica acta 96 21296186
2010 Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chemistry & biology 92 20534343
1992 Signal transduction by T- and B-cell antigen receptors: converging structures and concepts. Current opinion in immunology 83 1418703
2021 ADP-ribosylation of RNA and DNA: from in vitro characterization to in vivo function. Nucleic acids research 78 33693930
2014 Structure and function of the ARH family of ADP-ribosyl-acceptor hydrolases. DNA repair 72 24746921
2017 FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases. American journal of human genetics 71 28965846
2015 Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. The Journal of biological chemistry 65 25631044
2019 Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. Journal of pineal research 64 31077613
2018 (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition. Cell chemical biology 62 30472116
2002 Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1. The Journal of clinical investigation 59 12464675
2018 CD38 knockout suppresses tumorigenesis in mice and clonogenic growth of human lung cancer cells. Carcinogenesis 58 29228209
2007 Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice. Molecular and cellular biology 58 17526733
1999 YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin. Gene 53 10375636
2014 Efficient production of pullulan using rice hull hydrolysate by adaptive laboratory evolution of Aureobasidium pullulans. Bioresource technology 46 24835913
1998 Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. The Journal of biological chemistry 44 9727014
1998 ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Yeast (Chichester, England) 43 9818721
2011 Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3. The Journal of biological chemistry 42 21498885
2011 ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis. Cancer research 41 21697277
2013 Design and characterization of an efficient CYP105A1-based whole-cell biocatalyst for the conversion of resin acid diterpenoids in permeabilized Escherichia coli. Applied microbiology and biotechnology 34 23793341
2013 Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA. American journal of human genetics 34 23871723
2000 A new locus for autosomal recessive hypercholesterolemia maps to human chromosome 15q25-q26. American journal of human genetics 33 10677305
2015 EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer. Cell biochemistry and biophysics 32 25077680
2008 The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe. FEMS yeast research 28 18399988
2019 The ARH and Macrodomain Families of α-ADP-ribose-acceptor Hydrolases Catalyze α-NAD Hydrolysis. ACS chemical biology 25 31599159
2016 Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADP-Ribose) Polymerase-1 Response to Oxidative Stress. Current protein & peptide science 23 27090906
2004 Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1). Proteins 23 15211518
2018 Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair. JCI insight 22 30429362
2009 Prevalence and clinical features of heterozygous carriers of autosomal recessive hypercholesterolemia in Sardinia. Atherosclerosis 21 19477448
2018 Emerging roles of ADP-ribosyl-acceptor hydrolases (ARHs) in tumorigenesis and cell death pathways. Biochemical pharmacology 18 30267646
2015 Mutations of the functional ARH1 allele in tumors from ARH1 heterozygous mice and cells affect ARH1 catalytic activity, cell proliferation and tumorigenesis. Oncogenesis 18 26029825
1995 Differential binding activity of ARH1/TAM motifs. Immunology letters 18 7797258
1994 Reconstitution of CD3 zeta coupling to calcium mobilization via genetic complementation. The Journal of biological chemistry 16 7806507
2011 CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst. Journal of biotechnology 15 22202177
2022 Differences of macrophages in the tumor microenvironment as an underlying key factor in glioma patients. Frontiers in immunology 13 36389681
2022 Light-driven progesterone production by InP-(M. neoaurum) biohybrid system. Bioresources and bioprocessing 13 38647746
2018 Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice. PloS one 13 30500844
2022 ARH Family of ADP-Ribose-Acceptor Hydrolases. Cells 12 36497109
2003 Clinical and biochemical characterisation of patients with autosomal recessive hypercholesterolemia (ARH). Nutrition, metabolism, and cardiovascular diseases : NMCD 12 14717060
2025 A promising future for breast cancer therapy with hydroxamic acid-based histone deacetylase inhibitors. Bioorganic chemistry 10 39862739
2022 Are PARPs promiscuous? Bioscience reports 10 35380161
2007 In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae. BMC systems biology 10 17408500
2017 Genetic epidemiology of autosomal recessive hypercholesterolemia in Sicily: Identification by next-generation sequencing of a new kindred. Journal of clinical lipidology 9 29153781
2011 Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe. Journal of inorganic biochemistry 9 21536008
2020 ARH1 in Health and Disease. Cancers 8 32092898
2009 Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. Acta crystallographica. Section F, Structural biology and crystallization communications 8 19407395
2023 Macrodomain Mac1 of SARS-CoV-2 Nonstructural Protein 3 Hydrolyzes Diverse ADP-ribosylated Substrates. bioRxiv : the preprint server for biology 7 36945431
2021 Catalytic Properties of Flavocytochrome c Sulfide Dehydrogenase from Haloalkaliphilic Bacterium Thioalkalivibrio paradoxus. Biochemistry. Biokhimiia 6 33838635
2018 Mono-ADP-Ribosylhydrolase Assays. Methods in molecular biology (Clifton, N.J.) 4 30097869
2016 Signatures of Crested Ibis MHC Revealed by Recombination Screening and Short-Reads Assembly Strategy. PloS one 2 27997612
2005 Genomic organization and promoter analysis of the mouse ADP-ribosylarginine hydrolase gene. Gene 2 15893437
2024 Activation of Coq6p, a FAD Monooxygenase Involved in Coenzyme Q Biosynthesis, by Adrenodoxin Reductase/Ferredoxin. Chembiochem : a European journal of chemical biology 1 38141230
2023 ADP-ribose-acceptor hydrolase 2 ( Arh2 ) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival. bioRxiv : the preprint server for biology 0 36798189
2023 Mono-ADP-ribosyltransferase 1 ( Artc1 )-deficiency decreases tumorigenesis, increases inflammation, decreases cardiac contractility, and reduces survival. bioRxiv : the preprint server for biology 0 36945646
2019 Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene. Molecular omics 0 31429849

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