Affinage

ANK2

Ankyrin-2 · UniProt Q01484

Length
3957 aa
Mass
433.7 kDa
Annotated
2026-06-09
39 papers in source corpus 15 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Ankyrin-B (ANK2) is a multifunctional membrane scaffolding protein that recruits and stabilizes ion channels, transporters, and cell adhesion molecules at specialized plasma membrane domains in both cardiomyocytes and neurons (PMID:28196901, PMID:38290518). In the heart, ankyrin-B engages the Na/Ca exchanger through its membrane-binding domain, and loss-of-function variants that reduce ankyrin-B expression or membrane targeting disrupt Na/Ca exchanger localization and produce arrhythmias, action potential prolongation, and afterdepolarizations (PMID:17242276, PMID:28196901, PMID:27298202); it also functionally modulates the KCNH2 (hERG) potassium channel current (PMID:30929919). In the nervous system, the giant neurospecific isoform localizes to periodic axonal membrane domains via the L1 cell-adhesion molecule and couples microtubules to the plasma membrane, thereby restricting microtubule entry into nascent branches and limiting axon branching (PMID:31285321). Ankyrin-B scaffolds NaV1.2 (SCN2A) to dendritic membranes of neocortical pyramidal neurons, converging functionally with SCN2A as an autism risk gene (PMID:38290518), and maintains Kv7.2/Kv7.3 (KCNQ2/KCNQ3) channel density and normal axon initial segment structure, with its loss causing AIS elongation, network hyperexcitability, and seizure-related death that is rescued by the Kv7 agonist retigabine (PMID:37321992, PMID:37195288, PMID:37428632). Through NrCAM binding at a defined membrane-binding-domain pocket and β2-spectrin engagement via its spectrin-binding domain, ankyrin-B mediates Semaphorin 3F–dependent spine pruning and perisomatic CCK basket interneuron synaptic contacts onto pyramidal neurons. ANK2 also functions in cortical neural stem cell differentiation and neuronal migration (PMID:35313230) and in oocyte cytokinesis, where its spindle-localized isoform is translated after nuclear envelope breakdown (PMID:31511568). ANK2 protein levels are controlled post-translationally by USP46-mediated deubiquitination (PMID:40878243) and by PINK1-dependent Ser3781 phosphorylation (PMID:31277379), and isoform identity is governed by PTBP2-regulated exon 36 splicing (PMID:41555757).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2007 Medium

    Established that ANK2 variants causing graded cellular loss-of-function map onto clinical arrhythmia severity, framing ankyrin-B as a dose-sensitive regulator of cardiac electrogenesis.

    Evidence Primary cardiomyocyte assays of 9 nonsynonymous ANK2 variants

    PMID:17242276

    Open questions at the time
    • Did not resolve which molecular interactions each variant disrupts
    • Mechanism linking expression level to electrical phenotype not defined
  2. 2017 Medium

    Localized ankyrin-B function to its membrane-binding domain by showing a domain variant reduces expression and abolishes Na/Ca exchanger membrane targeting.

    Evidence H9c2 and primary cardiomyocyte expression/localization assays with p.S646F

    PMID:28196901

    Open questions at the time
    • Single lab, cell-based only
    • Did not test in vivo cardiac consequences of this variant
  3. 2019 High

    Demonstrated the giant neuronal isoform couples microtubules to the axonal membrane via L1-CAM to limit axon branching, defining a neuronal cytoskeleton-membrane scaffolding role distinct from cardiac function.

    Evidence Mouse ASD-mutation model, neuron branching assays, live imaging, behavior

    PMID:31285321

    Open questions at the time
    • Did not address dendritic or AIS roles
    • Branching mechanism in vivo circuit consequences incomplete
  4. 2019 Medium

    Confirmed in vivo that a destabilizing variant lowers cardiac ankyrin-B and Na/Ca exchanger association, causing arrhythmia and afterdepolarizations, linking protein stability to electrical phenotype.

    Evidence p.L1622I knock-in mouse, Co-IP, in vivo and cellular electrophysiology

    PMID:27298202

    Open questions at the time
    • Single lab
    • Mechanism of reduced posttranslational stability not defined
  5. 2019 Medium

    Extended ankyrin-B channel partnerships by showing functional interaction with KCNH2 (hERG) affecting potassium current and QT duration.

    Evidence Voltage-clamp in Xenopus oocytes with ANK2 C-terminal domain; HEK293 trafficking

    PMID:30929919

    Open questions at the time
    • Limited to C-terminal domain reconstitution
    • No native cardiomyocyte validation
  6. 2019 Medium

    Connected ANK2 to a neurodegeneration pathway by identifying PINK1-dependent Ser3781 phosphorylation and PINK1-dependent ANK2 expression.

    Evidence Quantitative brain phosphoproteomics and western blot in PINK1-KO+A53T-SNCA mice

    PMID:31277379

    Open questions at the time
    • Functional consequence of Ser3781 phosphorylation unknown
    • Direct vs indirect link to PINK1 not resolved
  7. 2019 Medium

    Revealed a non-neuronal, non-cardiac role: spindle-localized ANK2 translation after nuclear envelope breakdown is required for oocyte cytokinesis.

    Evidence Oocyte mRNA localization, translation inhibition, cytokinesis phenotype, 5'UTR motif analysis

    PMID:31511568

    Open questions at the time
    • Molecular partners at the spindle not identified
    • Mechanism of cytokinesis defect undefined
  8. 2022 Medium

    Implicated ANK2 in early cortical development through control of neural stem cell differentiation and neuronal migration.

    Evidence In utero electroporation knockdown, immunofluorescence, gene expression analysis

    PMID:35313230

    Open questions at the time
    • Single primary method
    • Direct molecular effectors of migration not defined
  9. 2023 High

    Defined ankyrin-B as a maintainer of Kv7.2/Kv7.3 density and AIS structure, with loss causing hyperexcitability and seizure death rescuable by a Kv7 agonist.

    Evidence Conditional Ank2-cKO mice, electrophysiology, AIS immunofluorescence, retigabine rescue

    PMID:37321992

    Open questions at the time
    • Direct ankyrin-B/Kv7 binding interface not mapped
    • Whether AIS elongation is cause or consequence unresolved
  10. 2023 High

    Validated ANK2 LoF phenotypes in a human neuronal model, showing network hyperactivity, altered AIS structure, and impaired activity-dependent AIS plasticity.

    Evidence CRISPR heterozygous LoF hiPSC-derived neurons, MEA, AIS morphology

    PMID:37195288

    Open questions at the time
    • Molecular driver of impaired AIS plasticity not identified
    • Channel-level mechanism in human neurons not dissected
  11. 2023 High

    Showed developmental-timing dependence of ANK2 loss and identified a synaptic interactome plus pharmacological rescue, linking ankyrin-B to network hypersynchrony.

    Evidence Multiple conditional KO mice, calcium imaging, synaptic membrane proteomics, perampanel rescue

    PMID:37428632

    Open questions at the time
    • Direct vs indirect membership of interactome partners not all validated
    • Mechanism of intermediate filament downregulation unclear
  12. 2024 High

    Established convergence of two ASD risk genes by showing ankyrin-B scaffolds NaV1.2 to dendritic membranes and Ank2 haploinsufficiency phenocopies Scn2a loss.

    Evidence Conditional KO mice, dendritic electrophysiology, NaV1.2 immunolocalization

    PMID:38290518

    Open questions at the time
    • Direct ankyrin-B/NaV1.2 binding interface not defined here
    • Whether convergence extends to synaptic deficits mechanistically incomplete
  13. 2024 Medium

    Identified a cell-type-specific synaptic role: ankyrin-B and NrCAM mediate CCK basket interneuron perisomatic contacts onto pyramidal neurons.

    Evidence Conditional KO, CCK-BC/PV-BC synaptic marker immunolabeling, reporter mouse (preprint)

    Open questions at the time
    • Preprint, single lab
    • Direct molecular requirement of NrCAM binding not separated from ankyrin-B loss
  14. 2025 Medium

    Mapped the structural basis for ankyrin-B partner binding, defining an NrCAM-engaging pocket and β2-spectrin interface and linking an ASD mutation to disrupted Sema3F-dependent spine pruning.

    Evidence AlphaFold modeling, mutagenesis Co-IP from HEK293, cortical neuron spine pruning assay (preprint)

    Open questions at the time
    • Preprint, single lab
    • Structural model not experimentally validated by direct structure
  15. 2025 Medium

    Defined post-translational control of ankyrin-B abundance via USP46 deubiquitination and linked elevated ANK2 to cardiomyocyte injury.

    Evidence Cycloheximide chase, ubiquitination assay, siRNA knockdown, rat I/R model

    PMID:40878243

    Open questions at the time
    • Single lab
    • Direct vs indirect USP46-ANK2 enzyme-substrate relationship in vivo not fully resolved
  16. 2025 Medium

    Connected ankyrin-B deficiency to mitochondrial dysfunction and MAVS-driven vascular inflammation, expanding its role beyond membrane scaffolding.

    Evidence ANK2 knockdown, multi-omics, mitochondrial morphology/potential assays, cytokine measurement

    PMID:41248744

    Open questions at the time
    • Mechanism linking ankyrin-B to mitochondrial cristae unknown
    • Whether effect is direct or secondary not established
  17. 2026 Medium

    Showed PTBP2-controlled ANK2 exon 36 splicing dictates an isoform required for RPE-to-neuron conversion, establishing isoform-specific functional identity.

    Evidence PTBP2 knockdown, splicing/transcriptomics, exon 36 isoform rescue in hRPE-19 cells

    PMID:41555757

    Open questions at the time
    • Functional protein-level difference of exon 36 isoform not biochemically defined
    • Relevance to in vivo neurogenesis unaddressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How distinct ankyrin-B isoforms, their domain-specific partner repertoires, and post-translational regulators are coordinated to produce tissue-specific outcomes across heart, brain, mitochondria, and dividing cells remains unresolved.
  • No unified map linking isoform/domain to partner selection across tissues
  • Functional roles of identified phosphorylation/ubiquitination sites not causally tested
  • Mitochondrial and cell-division roles lack defined molecular mechanism

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005886 plasma membrane 3 GO:0005739 mitochondrion 1 GO:0005856 cytoskeleton 1
Partners
KCNH2KCNQ2KCNQ3L1CAMNRCAMSCN2ASLC8A1SPTBN1

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 ANK2 loss-of-function variants in cardiomyocytes cause a spectrum of cellular phenotypes ranging from wild-type activity to severe loss-of-function, with the severity correlating with clinical arrhythmia phenotype. Ankyrin-B-dependent protein interactions regulate cardiac electrogenesis. Primary cardiomyocyte assays with 9 nonsynonymous ANK2 variants; loss-of-function characterization Circulation Medium 17242276
2019 Giant ankyrin-B (the neurospecific alternatively spliced ANK2 isoform) localizes to periodic axonal plasma membrane domains through L1 cell-adhesion molecule and couples microtubules to the plasma membrane, thereby preventing microtubule entry into nascent axon branches and limiting axon branching. Mouse model of human ASD mutation; cultured neuron branching assays; live imaging; genetic loss-of-function; behavioral analysis Proceedings of the National Academy of Sciences of the United States of America High 31285321
2024 Ankyrin-B is essential for scaffolding NaV1.2 (encoded by SCN2A) to the dendritic membrane of neocortical pyramidal neurons; Ank2 haploinsufficiency phenocopies intrinsic dendritic excitability and synaptic deficits seen in Scn2a+/- neurons, establishing a direct convergent link between these two ASD risk genes. Mouse conditional knockout (Ank2 haploinsufficiency); electrophysiology; immunofluorescence localization of NaV1.2 in dendrites Neuron High 38290518
2017 ANK2 variant p.S646F (in the membrane-binding domain) causes reduced ankyrin-B expression in H9c2 cells and aberrant cardiomyocyte localization, and results in loss of normal membrane targeting of the Na/Ca exchanger (a known ankyrin-B binding partner), identifying the membrane-binding domain as critical for ankyrin-B function. Bacterial expression for folding assessment; H9c2 cell expression; primary cardiomyocyte localization assays; immunofluorescence of Na/Ca exchanger targeting Circulation. Cardiovascular genetics Medium 28196901
2023 Ank2 knockout restricted to cortical and hippocampal excitatory neurons reduces total levels and density of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 potassium channels at the axon initial segment (AIS) and causes elongated AIS, resulting in abnormally increased neuronal excitability and seizure-related death; Kv7 agonist retigabine rescues these phenotypes. Conditional knockout mice (Ank2-cKO); electrophysiology; immunofluorescence of AIS markers and Kv7 channels; pharmacological rescue with retigabine Nature communications High 37321992
2023 ANK2 loss-of-function in hiPSC-derived neurons produces hyperactive and desynchronized neuronal network activity (measured by MEA), increased somatodendritic complexity, altered axon initial segment (AIS) structure, and impaired activity-dependent AIS plasticity. CRISPR/Cas9 heterozygous ANK2 LoF allele in hiPSCs; differentiation to excitatory neurons; micro-electrode array (MEA) electrophysiology; morphological characterization of AIS Human molecular genetics High 37195288
2023 Prenatal (but not adolescent) deletion of Ank2 in cortical excitatory neurons and oligodendrocytes causes spontaneous seizures, network hyperexcitability/hypersynchrony, and upregulation of dendritic spine plasticity-regulatory proteins and downregulation of intermediate filaments at synaptic membranes. Ankyrin-B interactome contains autism/epilepsy risk factors and synaptic proteins. AMPA receptor antagonist perampanel restores cortical activity. Conditional knockout mice (Ank2-/-:Emx1-Cre vs Ank2-/-:CaMKIIα-Cre); calcium imaging of cortical slices; quantitative proteomic analysis of synaptic membranes; interactome characterization; pharmacological rescue Cell reports High 37428632
2019 ANK2 variant p.L1622I displays reduced posttranslational expression in vivo, resulting in reduced cardiac ankyrin-B expression and reduced association with the Na/Ca exchanger binding partner; knock-in mice show arrhythmias, action potential duration increases, and afterdepolarizations. Knock-in mouse model; co-immunoprecipitation for Na/Ca exchanger association; in vivo electrophysiology; cellular action potential recordings Heart rhythm Medium 27298202
2019 ANK2-E1813K diminishes currents mediated by combined wild-type and H562R KCNH2 subunits in Xenopus oocytes, indicating that ANK2 functionally interacts with KCNH2 (hERG) to modulate potassium channel current and QT interval duration. Voltage-clamp recordings in Xenopus oocytes with co-expression of ANK2 C-terminal regulatory domain and KCNH2 constructs; HEK293 trafficking assay Biochemical and biophysical research communications Medium 30929919
2019 ANK2 (Ser3781) phosphorylation is dramatically reduced (>300-fold) in brains of PINK1-KO+A53T-SNCA mice, and ANK2/MAP1B expression depends on PINK1 levels, linking ANK2 post-translational phosphorylation to the PINK1/Parkin pathway. Quantitative label-free global phosphoproteomic mass spectrometry of mouse brain hemispheres; western blot validation of ANK2/MAP1B expression relative to PINK1 levels International journal of molecular sciences Medium 31277379
2019 ANK2 translation occurs specifically after nuclear envelope breakdown in mouse oocytes, with Ank2.3 mRNA localizing to the forming spindle; prevention of ANK2 translation causes cytokinesis abnormalities in oocytes. The 5'UTR contains an oligo-pyrimidine motif determining cap-dependent translation. mRNA localization in oocytes; translation inhibition experiments; cytokinesis phenotype quantification; 5'UTR motif analysis Scientific reports Medium 31511568
2022 ANK2 regulates neural stem cell differentiation and neuronal migration in the embryonic cerebral cortex; Ank2 knockdown via in utero electroporation alters expression of genes involved in neural development. In utero electroporation knockdown in mouse embryonic cerebral cortex; immunofluorescence; gene expression analysis Biochemical and biophysical research communications Medium 35313230
2025 ANK2 deficiency induces mitochondrial cristae disorganization and membrane hyperpolarization, leading to bioenergetic stress and activation of the mitochondrial antiviral-signaling protein (MAVS); MAVS oligomerization enhances IL-6/IL-8 secretion, establishing an ANK2-MAVS-IL-8 axis connecting mitochondrial dysfunction to vascular inflammation. ANK2 knockdown cellular models; multi-omics (RNA-seq, proteomics, metabolomics, ATAC-seq); mitochondrial morphology and membrane potential assays; cytokine secretion measurement Free radical biology & medicine Medium 41248744
2025 USP46 stabilizes ANK2 protein by deubiquitination (preventing its degradation), and elevated ANK2 in hypoxia/reoxygenation-treated cardiomyocytes promotes apoptosis, inflammation, and ferroptosis; USP46 knockdown reduces ANK2 and alleviates myocardial injury in rats. Cycloheximide chase assay; ubiquitination assay; siRNA knockdown; flow cytometry for apoptosis; in vivo rat I/R model Journal of biochemical and molecular toxicology Medium 40878243
2025 AlphaFold modeling and mutagenesis identified a pocket in the ANK2 membrane-binding domain that engages NrCAM at the conserved FIGQY cytoplasmic motif, and key interactions between the ANK2 spectrin-binding domain and β2-Spectrin repeats 14-15. ASD missense mutation AnkB A368G (NrCAM binding pocket) disrupted NrCAM association and impaired Semaphorin 3F-induced spine pruning in cortical neurons; AnkB R977Q disrupted β2-Spectrin association. AlphaFold structural modeling; co-immunoprecipitation from HEK293 cells with mutant constructs; cortical neuron spine pruning assay bioRxivpreprint Medium
2024 Ankyrin-B and NrCAM mediate perisomatic synaptic contact between CCK basket interneurons and pyramidal neurons in mouse mPFC; deletion of Ankyrin-B from pyramidal neurons (via Nex1Cre-ERT2:Ank2flox/flox) decreases CCK-BC synaptic puncta on PN soma, while PV-BC contacts are unaffected. Conditional knockout (Nex1Cre-ERT2:Ank2flox/flox); immunolabeling for CCK-BC and PV-BC synaptic markers (VGLUT3, VGAT); CCK-BC reporter mouse (tdT at Sncg locus) bioRxivpreprint Medium
2026 PTBP2 splicing regulator controls ANK2 exon 36 inclusion; loss of PTBP2 promotes near-complete inclusion of ANK2 exon 36, and this isoform switch is mechanistically required for RPE-to-neuron conversion — loss of exon 36 impairs neuronal induction, and re-expression of the exon-36-containing isoform restores conversion efficiency. PTBP2 knockdown in hRPE-19 cells; transcriptomic and splicing analysis; functional rescue assays with ANK2 exon 36 isoform Journal of neurochemistry Medium 41555757

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation 128 17242276
2019 ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity. Proceedings of the National Academy of Sciences of the United States of America 85 31285321
2018 Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis. International journal of molecular medicine 46 29328428
2024 Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites. Neuron 38 38290518
2017 Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome. Circulation. Cardiovascular genetics 37 28196901
2008 Exon organization and novel alternative splicing of the human ANK2 gene: implications for cardiac function and human cardiac disease. Journal of molecular and cellular cardiology 33 18790697
2020 lncRNA ZNF667-AS1 (NR_036521.1) inhibits the progression of colorectal cancer via regulating ANK2/JAK2 expression. Journal of cellular physiology 27 32853419
2008 Common genetic variants in ANK2 modulate QT interval: results from the KORA study. Circulation. Cardiovascular genetics 27 20031550
2023 Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nature communications 24 37321992
2023 ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks. Human molecular genetics 21 37195288
2022 Autism-associated ANK2 regulates embryonic neurodevelopment. Biochemical and biophysical research communications 18 35313230
1993 Distinct fetal Ank-1 and Ank-2 related proteins and mRNAs in normal and nb/nb mice. Blood 17 8471772
2019 SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes. International journal of molecular sciences 16 31277379
2020 ANK2 Hypermethylation in Canine Mammary Tumors and Human Breast Cancer. International journal of molecular sciences 14 33218035
2003 LQT4 gene: the "missing" ankyrin. Molecular interventions 11 14993420
2016 Common human ANK2 variant confers in vivo arrhythmia phenotypes. Heart rhythm 10 27298202
2024 Roles of ANK2/ankyrin-B in neurodevelopmental disorders: Isoform functions and implications for autism spectrum disorder and epilepsy. Current opinion in neurobiology 9 39631164
2019 Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes. Scientific reports 9 31511568
2023 Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome. Cell reports 8 37428632
2022 ANK2 as a novel predictive biomarker for immune checkpoint inhibitors and its correlation with antitumor immunity in lung adenocarcinoma. BMC pulmonary medicine 8 36539782
2019 ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier. Biochemical and biophysical research communications 7 30929919
2024 Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene variants. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 6 38507076
2007 Mutation analysis of candidate genes SCN1B, KCND3 and ANK2 in patients with clinical diagnosis of long QT syndrome. Physiological research 6 18052691
2023 Discovering the ANK2-related autism phenotype. Clinical genetics 4 37088467
2025 A Mutation in the ANK2 Gene Causing ASD and a Review of the Literature. Molecular genetics & genomic medicine 2 40035441
2025 ANK2-MAVS signaling dysfunction triggers mitochondrial stress and enhances IL-8 mediated inflammatory responses in Takayasu arteritis. Free radical biology & medicine 2 41248744
2026 Construction of a Mitochondria-Related Gene Diagnostic Model Based on Integrated Multiomics Data and Functional Validation of ANK2 as a Key Regulator in Colorectal Cancer. International journal of genomics 1 41626625
2025 Left Ventricular Non-Compaction, Atrial Fibrillation and ANK2 Mutation in a Young Athlete. Journal of clinical medicine research 1 39866811
2025 Self-limited familial focal epilepsy caused by ANK2 variants: A potentially under-recognized condition. Epilepsia open 1 39962910
2025 Variability in autism spectrum phenotypes linked to heterozygous missense familial ANK2 mutation. European journal of medical genetics 1 39978592
2026 Isoform-Specific Splicing of ANK2 by PTBP2 Orchestrates Retinal Pigment Epithelial-to-Neuron Fate Conversion. Journal of neurochemistry 0 41555757
2026 Unmasking Brugada ECG Pattern in Myotonic Dystrophy Type 2 With an ANK2 Variant. Pacing and clinical electrophysiology : PACE 0 41733445
2026 Metabolic-Epigenetic Crosstalk in Takayasu Arteritis: The ANK2-MAVS-IL-8 Axis as a Novel Therapeutic Paradigm. International journal of molecular sciences 0 41977430
2025 A Neuron-Like Cellular Model for Severe Tinnitus Associated with Rare Variations in the ANK2 Gene. Molecular neurobiology 0 39815069
2025 Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions. Reviews in cardiovascular medicine 0 39867173
2025 Correction to: Left Ventricular Non-Compaction, Atrial Fibrillation and ANK2 Mutation in a Young Athlete. Journal of clinical medicine research 0 40503066
2025 Inhibition of USP46/ANK2 Axis Alleviates Myocardial Infarction in Hypoxia/Reoxygenation-Treated Cardiomyocytes and Ischemia/Reperfusion-Induced Rat Models. Journal of biochemical and molecular toxicology 0 40878243
2020 Publisher Correction: Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes. Scientific reports 0 32066832
2020 Author Correction: Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes. Scientific reports 0 32424126

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