Affinage

ADRA1D

Alpha-1D adrenergic receptor · UniProt P25100

Length
572 aa
Mass
60.5 kDa
Annotated
2026-06-09
85 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ADRA1D is a plasma-membrane G protein-coupled α1-adrenergic receptor that organizes into an obligate modular homodimer scaffolded through its C-terminal Type I PDZ ligand by the PDZ proteins syntrophin (SNTA, SNTB1, SNTB2) and scribble (SCRIB), which compete for the ligand yet can coexist within the multimer; syntrophins drive plasma-membrane localization and G-protein coupling while SCRIB and syntrophins impart divergent pharmacology (PMID:26617989). The receptor undergoes endogenous N-terminal cleavage at Leu90/Val91 to generate a Δ1-91 isoform with enhanced agonist-stimulated signaling, and abolishing this processing reduces responsiveness below wild-type (PMID:27382054). ADRA1D is among the most short-lived adrenergic receptors, turning over rapidly via the proteasome (PMID:33402011). In vascular smooth muscle, Adra1d is a direct transcriptional target of PRDM16, and loss of this regulation lowers blood pressure during the active period and blunts phenylephrine-induced arterial contraction, linking the receptor to circadian blood-pressure control (PMID:39625782); its vasoconstrictor signaling is further sensitized by L-DOPA acting through GPR143 to amplify phenylephrine-induced Ca2+ and ERK responses (PMID:28931752). Across endothelial, neuronal, and immune contexts, ADRA1D acts as a proximal driver of intracellular Ca2+-dependent signaling — engaging the Ca2+/calcineurin/NFAT1 axis to promote endothelial-to-mesenchymal transition (PMID:40398181) and, via heterodimerization with CXCR4, triggering Ca2+ overload and STING/NF-κB/NLRP3 activation that promotes tau hyperphosphorylation and neuroinflammation (PMID:40676669). ADRA1D expression is also required for skeletal myoblast survival (PMID:20110686).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2010 Medium

    Established that ADRA1D expression has a cell-survival function beyond classical vasoactive signaling, in skeletal muscle.

    Evidence siRNA knockdown with viability readout under TNF-α/IGF-I conditions in C2 myoblasts

    PMID:20110686

    Open questions at the time
    • Downstream survival pathway not defined
    • No receptor-domain or signaling mechanism linked to the phenotype
  2. 2015 High

    Defined the structural and scaffolding architecture of the receptor, answering how ADRA1D reaches the membrane and couples to G proteins.

    Evidence TAP/MS, reciprocal Co-IP, DMR functional assays with 23-GPCR negative control

    PMID:26617989

    Open questions at the time
    • No structural model of the homodimer or PDZ interface
    • Functional consequence of SCRIB vs syntrophin competition not fully resolved
  3. 2016 High

    Identified an endogenous N-terminal cleavage event that generates a signaling-enhanced receptor isoform, revealing post-translational tuning of agonist responsiveness.

    Evidence NIR imaging, TAP-MS/MS, serial truncation and cleavage-site mutagenesis, DMR signaling assays in human cells

    PMID:27382054

    Open questions at the time
    • Protease responsible for Leu90/Val91 cleavage unidentified
    • Physiological regulation of cleavage in vivo unknown
  4. 2017 Medium

    Showed that ADRA1 vasoconstrictor signaling is sensitized by L-DOPA through GPR143, connecting receptor function to blood-pressure regulation.

    Evidence Gpr143 whole-body and VSMC-specific KO mice, telemetric BP, VSMC Ca2+ imaging, ERK phosphorylation

    PMID:28931752

    Open questions at the time
    • Direct ADRA1D-GPR143 interaction not demonstrated (subtype specificity within ADRA1 unresolved)
    • Mechanism of sensitization at the receptor level undefined
  5. 2021 Medium

    Quantified ADRA1D turnover, establishing it as the shortest-lived adrenergic receptor and proteasome-dependent for degradation.

    Evidence SNAP/NIR cycloheximide-chase degradation assay with bortezomib in 96-well and PAGE formats

    PMID:33402011

    Open questions at the time
    • E3 ligase and degradation signal not identified
    • Single-lab measurement in heterologous cells
  6. 2023 Medium

    Mapped the TM2 interface used by GPR143 to augment ADRA1-subfamily signaling, providing a molecular handle for the sensitization mechanism.

    Evidence Chimeric TM-domain swapping, Co-IP, TAT-TM2 peptide disruption, ERK assays (study centered on ADRA1B)

    PMID:37394637

    Open questions at the time
    • Direct relevance to ADRA1D vs ADRA1B not established
    • No structural validation of the interface
  7. 2024 High

    Identified ADRA1D as a direct transcriptional target of PRDM16 in VSMCs controlling circadian blood-pressure variation.

    Evidence VSMC-specific Prdm16 KO mice, BP telemetry, ex vivo mesenteric artery myography with phenylephrine

    PMID:39625782

    Open questions at the time
    • Direct PRDM16 occupancy at the Adra1d locus not detailed here
    • Relative contribution of Adra1d vs clock-gene regulation to phenotype unresolved
  8. 2025 Medium

    Placed ADRA1D as a proximal Ca2+-driven effector across endothelial and neuronal pathology, signaling through calcineurin/NFAT1 (EndMT) and CXCR4-heterodimer/STING/NF-κB/NLRP3 (tauopathy/neuroinflammation).

    Evidence EC- and neuron-specific overexpression/knockdown in vivo and in vitro, Co-IP for CXCR4 heterodimer, Ca2+ flux and calcineurin assays, behavioral and tau readouts

    PMID:40393970 PMID:40398181 PMID:40676669

    Open questions at the time
    • Whether the same receptor pool drives both calcineurin/NFAT1 and STING/NLRP3 outputs is unclear
    • ADRA1D-CXCR4 heterodimer requires reciprocal structural validation

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the receptor's structural features (cleavage, dimerization, PDZ scaffolding, rapid turnover) mechanistically dictate which downstream Ca2+ pathway is engaged in a given tissue remains unknown.
  • No unified model linking receptor processing/scaffolding to pathway selection
  • Protease and E3 ligase identities unknown
  • Subtype-specific roles vs ADRA1A/ADRA1B not delineated in shared pathways

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2
Localization
GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 1
Partners
CXCR4GPR143SCRIBSNTA1SNTB1SNTB2

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 ADRA1D undergoes endogenous N-terminal (NT) domain cleavage at Leu90/Val91 in cultured human cells, producing a Δ1-91 isoform. This cleavage is not required for formation of scribble-syntrophin macromolecular complexes, but the Δ1-91 isoform shows greater agonist-stimulated functional responses than wild-type ADRA1D. Mutagenesis of the cleavage site abolished NT processing and reduced agonist responses below wild-type levels. SNAP near-infrared imaging, tandem-affinity purification MS/MS, co-immunoprecipitation, serial truncation mutagenesis, label-free dynamic mass redistribution signaling assays The Journal of biological chemistry High 27382054
2015 ADRA1D forms an obligate modular homodimer at the plasma membrane that binds the PDZ scaffold proteins syntrophin (SNTA, SNTB1, SNTB2) and scribble (SCRIB) through its C-terminal PDZ ligand. Syntrophins and SCRIB compete for the PDZ ligand and can simultaneously co-exist within the ADRA1D multimer. Syntrophins ensure receptor plasma membrane localization and G-protein coupling, while SCRIB and syntrophins impart divergent pharmacological properties. No other GPCRs among 23 tested with Type I PDZ ligands interacted with syntrophins. Tandem affinity purification/mass spectrometry (TAP/MS), co-immunoprecipitation, dynamic mass redistribution functional assays, biochemical fractionation Cell discovery High 26617989
2021 ADRA1D protein was quantified to have the shortest degradation half-life (t1/2 = 0.52 h) among all nine adrenergic receptor subtypes tested, and degradation occurs primarily through the proteasome (reversed by bortezomib treatment). SNAP-epitope tag/near-infrared imaging cycloheximide-chase degradation assay, proteasome inhibitor (bortezomib) treatment, 96-well plate format SLAS discovery : advancing life sciences R & D Medium 33402011
2024 PRDM16, a transcription factor expressed in vascular smooth muscle cells (VSMCs), directly regulates the transcription of Adra1d. VSMC-specific Prdm16 knockout mice show significantly lower blood pressure during the active period and reduced mesenteric artery contraction in response to phenylephrine (an α1-adrenergic agonist), resulting in aberrant blood pressure circadian variation. PRDM16 also regulates clock genes (particularly Npas2) that control BP circadian variation. VSMC-specific conditional knockout mice, telemetric blood pressure measurement, ex vivo mesenteric artery myography with phenylephrine, transcriptional target identification The Journal of clinical investigation High 39625782
2010 Adra1d expression in C2 skeletal myoblasts is upregulated under survival conditions (IGF-I rescue of high-dose TNF-α-induced death) and downregulated under apoptotic conditions. siRNA knockdown of Adra1d resulted in significantly higher cell death across all incubation conditions, establishing that Adra1d expression is essential for skeletal myoblast survival. Insulin signaling array, qRT-PCR, siRNA gene silencing, cell viability assays under defined TNF-α/IGF-I conditions Cellular physiology and biochemistry Medium 20110686
2020 Patulin (PAT) exposure in HEK293 cells decreased ADRA1D mRNA and protein expression and altered downstream AMPK pathway signaling (ERK1/2, PI3K/Akt). Molecular docking indicated direct interaction of PAT with ADRA1A (and PRKAG3). NAC (antioxidant) ameliorated PAT-induced suppression of α1-AR, while BSO (GSH inhibitor) potentiated it, linking oxidative stress to ADRA1D downregulation. qPCR, western blotting, molecular docking, pharmacological modulation (Epi, metformin, BSO, NAC) Scientific reports Low 33208818
2025 In Alzheimer's disease mouse models (3xTg-AD), ADRA1 expression and epinephrine (EPI) levels are elevated. Neuronal ADRA1D knockdown (via intracerebroventricular AAV) suppressed STING/NF-κB/NLRP3 pathway activation, ameliorated tau hyperphosphorylation, and improved cognitive function. ADRA1D overexpression in wild-type mice induced tauopathy and neuroinflammation. Mechanistically, ADRA1D interacts with CXCR4 to form heterodimers, triggering cytoplasmic Ca2+ overload and STING/NF-κB/NLRP3 pathway activation. AAV-mediated neuronal ADRA1D knockdown and overexpression, co-immunoprecipitation, calcium flux assays, pharmacological antagonists, Western blot, behavioral testing Journal of neuroinflammation Medium 40676669
2025 In 3xTg-AD mice, gastrodin inhibits the ADRA1/NF-κB/NLRP3 pathway, reducing tau phosphorylation and neuroinflammation. Lentiviral overexpression of ADRA1 in vitro reversed gastrodin's suppression of NF-κB/NLRP3 activation and inflammatory cytokine release (IL-1β, IL-18). Aβ42-induced upregulation of ADRA1/NF-κB/NLRP3 was inhibited by gastrodin in SH-SY5Y cells. Lentiviral ADRA1 overexpression, Western blot, immunohistochemistry, ELISA, in vitro Aβ42 cell model Phytotherapy research : PTR Low 39963073
2025 Lonicerin reduces high glucose-induced upregulation of ADRA1D in human aortic endothelial cells (HAECs), leading to decreased cytoplasmic Ca2+ levels, inhibition of calcineurin activity, NFAT1 phosphorylation, and prevention of endothelial-to-mesenchymal transition (EndMT). EC-specific overexpression of ADRA1D negated the inhibitory effects of lonicerin on EndMT and its therapeutic impact on diabetic vascular injury, establishing ADRA1D as a proximal mediator of the Ca2+/Calcineurin/NFAT1-dependent EndMT pathway. RNAi, plasmid overexpression, Western blot, qRT-PCR, immunofluorescence, flow cytometry, calcineurin activity assay, RNA sequencing, STZ-induced diabetic mouse model Phytomedicine Medium 40398181
2023 In a bleomycin mouse lung fibrosis model, noradrenaline from local adrenergic nerves (not adrenal sources) drives emergence of an αSMA+ fibroblast population expressing ADRA1D. Therapeutic delivery of the α1 adrenoreceptor antagonist terazosin reversed fibroblast accumulation and suppressed extracellular mitochondrial DNA (mtDNA) accumulation. In cultured normal human lung fibroblasts, costimulation with TGFβ1 and NA induced ADRA1D expression, ACTA2 upregulation, and extracellular mtDNA release, all opposed by terazosin. Surgical adrenergic nerve ablation vs. adrenal resection in bleomycin model, pharmacological antagonism (terazosin), cultured human lung fibroblasts with TGFβ1/NA stimulation, αSMA/ADRA1D immunostaining American journal of physiology. Lung cellular and molecular physiology Medium 36648147
2021 In an in vitro OGD (oxygen-glucose deprivation) model of vascular dementia using PC12 cells, ADRA1D overexpression decreased apoptosis and lowered intracellular Ca2+ levels, while ADRA1D knockdown increased apoptosis and elevated Ca2+. Mechanistically, ADRA1D overexpression reduced PLCβ and IP3R expression, suggesting ADRA1D modulates Ca2+ homeostasis via the PLCβ/IP3R pathway. OGD PC12 cell model, lentiviral overexpression and siRNA knockdown of ADRA1D, TUNEL assay, RT-qPCR, Western blot, Fluo-3 AM Ca2+ imaging Actas espanolas de psiquiatria Low 38622006
2025 In chromogranin A (CgA) knockout/PS19 tauopathy mice, cortical epinephrine (EPI) levels and Adra1 expression (elevated in PS19 mice relative to WT) were reduced back to near-normal. Treatment of WT hippocampal organotypic slice cultures with EPI or an Adra1 agonist promoted tau hyperphosphorylation and neurofibrillary tangle formation, while an Adra1 antagonist inhibited these effects, establishing a functional EPI-Adra1 signaling axis in tau pathogenesis. Transgenic mouse models (CgA-KO/PS19), transcriptomic and metabolite analysis, hippocampal organotypic slice culture pharmacology (EPI, Adra1 agonist, Adra1 antagonist), immunohistochemistry Nature communications Medium 40393970
2025 Osthol (OST) downregulates ADRA1D expression in obese mice, suppressing Th17 differentiation (reduced CD4+IL-17A+ and CD4+RORγt+ cells). ADRA1D overexpression in vitro and in vivo partially reversed OST-mediated suppression of Th17 polarization, expression of lipogenic genes (FASN, PPARγ), and lipid droplet accumulation, establishing ADRA1D as a mediator of Th17 differentiation linked to obesity-associated immunometabolic dysregulation. HFD mouse model, in vitro Th17 differentiation (primary murine CD4+ T cells), ADRA1D overexpression (cells and mice), flow cytometry, ELISA, RT-qPCR, Western blot Scientific reports Low 41120583
2019 ADRA1D mRNA and protein are downregulated in the injured spinal cord following brachial plexus root avulsion. The lncRNA MRAK034299, which targets Adra1d, is also downregulated post-avulsion, suggesting a lncRNA-mediated epigenetic mechanism contributes to reduced ADRA1D expression in motoneuron injury context. Microarray lncRNA/mRNA profiling, qRT-PCR validation, Western blot, immunofluorescence, in vivo rat brachial plexus avulsion model Neurochemistry international Low 31783066
2017 L-DOPA sensitizes vascular ADRA1 (alpha-1 adrenergic receptor) signaling in vascular smooth muscle cells (VSMCs) via the L-DOPA receptor GPR143. Specific knockout of Gpr143 in VSMCs attenuated phenylephrine-induced blood pressure elevation. L-DOPA enhanced phenylephrine-induced vasoconstriction and intracellular Ca2+ responses in vitro. Phenylephrine-augmented ERK phosphorylation was present in WT but not Gpr143-/y VSMCs. Gpr143 whole-body and VSMC-specific knockout mice, intravenous phenylephrine infusion with telemetric blood pressure, in vitro VSMC Ca2+ imaging, ERK phosphorylation assay JCI insight Medium 28931752
2023 L-DOPA receptor GPR143 physically interacts with ADRA1B at the second transmembrane (TM2) domain interface. A synthetic TAT-TM2 peptide disrupted the GPR143-ADRA1B interaction (co-immunoprecipitation) and suppressed GPR143-augmented phenylephrine-induced ERK phosphorylation in HEK293T cells co-expressing ADRA1B and GPR143. Chimeric receptor analysis (TM domain swapping), co-immunoprecipitation, TAT-peptide disruption, ERK phosphorylation assay in HEK293T cells Biological & pharmaceutical bulletin Medium 37394637

Source papers

Stage 0 corpus · 85 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model. Neuropharmacology 199 26577018
2017 Glucocorticoids, genes and brain function. Progress in neuro-psychopharmacology & biological psychiatry 107 29180230
1993 A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization. Genomics 70 8325647
1991 Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics 70 1889803
1991 Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics 67 1676978
2016 Surgery accelerates the development of endometriosis in mice. American journal of obstetrics and gynecology 57 26945602
2013 Methylomics analysis identifies epigenetically silenced genes and implies an activation of β-catenin signaling in cervical cancer. International journal of cancer 57 24310984
2016 Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2. Human reproduction (Oxford, England) 55 27664956
2012 Clinical response and side effects of metoclopramide: associations with clinical, demographic, and pharmacogenetic parameters. Journal of clinical gastroenterology 52 22688145
2016 Evolutionary Genetics of Hypoxia Tolerance in Cetaceans during Diving. Genome biology and evolution 51 26912402
2012 Genome-wide genetic associations with IFNγ response to smallpox vaccine. Human genetics 46 22661280
2010 Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Digestive diseases and sciences 45 21063774
2016 l-glutamine Improves Skeletal Muscle Cell Differentiation and Prevents Myotube Atrophy After Cytokine (TNF-α) Stress Via Reduced p38 MAPK Signal Transduction. Journal of cellular physiology 43 26991744
2018 Silver Nanoparticle Exposure Induces Neurotoxicity in the Rat Hippocampus Without Increasing the Blood-Brain Barrier Permeability. Journal of biomedical nanotechnology 40 29944106
2017 Utility of miR‑133a‑3p as a diagnostic indicator for hepatocellular carcinoma: An investigation combined with GEO, TCGA, meta‑analysis and bioinformatics. Molecular medicine reports 30 29138825
2015 The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients. Schizophrenia research 28 26381449
2014 Genome wide expression analysis suggests perturbation of vascular homeostasis during high altitude pulmonary edema. PloS one 28 24465776
2002 Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis. The Journal of urology 25 12442007
2018 Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature. Pharmacological research 22 29870805
2016 Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics. The Journal of biological chemistry 22 27382054
1993 Genetic mapping and evaluation of candidate genes for spasmodic, a neurological mouse mutation with abnormal startle response. Genomics 21 8406478
2024 Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure. The Journal of clinical investigation 19 39625782
2019 POLR1B is upregulated and promotes cell proliferation in non-small cell lung cancer. Oncology letters 19 31897183
2017 L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor. JCI insight 19 28931752
2013 Sustained in vivo blockade of α₁-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cells. American journal of physiology. Endocrinology and metabolism 18 23695211
2022 Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. International journal of molecular sciences 17 35955642
2012 Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis. PloS one 17 22615923
2021 The mechanisms of action of WeiChang'An Pill (WCAP) treat diarrhoea-predominant irritable bowel syndrome (IBS-D) using network pharmacology approach and in vivo studies. Journal of ethnopharmacology 16 33862102
2021 QiShenYiQi ameliorates salt-induced hypertensive nephropathy by balancing ADRA1D and SIK1 expression in Dahl salt-sensitive rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 16 34328102
2016 From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC). PloS one 16 26735301
2014 Effects of colostrum versus formula feeding on hepatic glucocorticoid and α₁- and β₂-adrenergic receptors in neonatal calves and their effect on glucose and lipid metabolism. Journal of dairy science 16 25108854
2007 Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. The pharmacogenomics journal 16 17404580
2015 Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome. PloS one 15 26288143
2012 Benzo[α]pyrene-induced anti-depressive-like behaviour in adult female mice: role of monoaminergic systems. Basic & clinical pharmacology & toxicology 15 22212102
2015 Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell discovery 14 26617989
2014 Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia. International neurourology journal 14 25558416
2022 Serum bone remodeling parameters and transcriptome profiling reveal abnormal bone metabolism associated with keel bone fractures in laying hens. Poultry science 13 36780704
2025 Chromogranin A deficiency attenuates tauopathy by altering epinephrine-alpha-adrenergic receptor signaling in PS19 mice. Nature communications 11 40393970
2014 Developmental genetic profiles of glutamate receptor system, neuromodulator system, protector of normal tissue and mitochondria, and reelin in marmoset cortex: potential molecular mechanisms of pruning phase of spines in primate synaptic formation process during the end of infancy and prepuberty (II). Biochemical and biophysical research communications 11 24440696
2025 Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation. Phytotherapy research : PTR 10 39963073
2020 Epinephrine responsiveness is reduced in livers from trained mice. Physiological reports 10 32061187
2020 Patulin suppresses α1-adrenergic receptor expression in HEK293 cells. Scientific reports 10 33208818
2020 Terazosin reduces steroidogenic factor 1 and upregulates heat shock protein 90 expression in LH-induced bovine ovarian theca cells. Free radical biology & medicine 10 33352221
2010 C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 10 20110686
2024 Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot. American journal of hematology 9 39564730
2023 α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology 9 36648147
2020 Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant. The American journal of drug and alcohol abuse 9 31914324
2004 Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past. Molecular genetics and genomics : MGG 9 15503142
2023 Chronic unpredictable stress induces depression/anxiety-related behaviors and alterations of hippocampal monoamine receptor mRNA expression in female mice at different ages. Heliyon 8 37539192
2021 Involvement of the Catecholamine Pathway in Glioblastoma Development. Cells 8 33806345
2023 Acupuncture Therapy on Dementia: Explained with an Integrated Analysis on Therapeutic Targets and Associated Mechanisms. Journal of Alzheimer's disease : JAD 7 36776063
2021 Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model. Molecular genetics and metabolism reports 7 33898262
2025 Modulation of neuronal α1-adrenergic receptor reduces tauopathy and neuroinflammation by inhibiting the STING/NF-κB/NLRP3 signaling pathway in Alzheimer's disease mice. Journal of neuroinflammation 6 40676669
2022 Role of sympathetic pathway in light-phase time-restricted feeding-induced blood pressure circadian rhythm alteration. Frontiers in nutrition 6 36159491
2025 Integrated multiomic profiling of tail adipose tissue highlights novel genes, lipids, and metabolites involved in tail fat deposition in sheep. BMC genomics 5 40033184
2024 Genes related to neurotransmitter receptors as potential biomarkers for Alzheimer's disease. Neuroscience letters 5 38729598
2023 Integrated LC-MS/MS and network pharmacology approach for predictingactive ingredients and pharmacological mechanisms of Tribulus terrestris L. against cardiac diseases. Journal of biomolecular structure & dynamics 5 37042962
2020 Does the Act of Copulation per se, without Considering Seminal Deposition, Change the Expression of Genes in the Porcine Female Genital Tract? International journal of molecular sciences 5 32751869
2017 Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell. Experimental and therapeutic medicine 5 28413470
2021 Development of a Novel SNAP-Epitope Tag/Near-Infrared Imaging Assay to Quantify G Protein-Coupled Receptor Degradation in Human Cells. SLAS discovery : advancing life sciences R & D 4 33402011
2021 β2-adrenoreceptors control human skin microvascular reactivity. European journal of dermatology : EJD 4 34309518
2021 Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor. Journal of pharmacological sciences 4 35063136
2020 Mechanism underpinning effects of Shichangpu (Rhizoma Acori Tatarinowii) on attention deficit hyperactivity disorder. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 3 32227770
2019 The temporal pattern of brachial plexus root avulsion-induced lncRNA and mRNA expression prior to the motoneuron loss in the injured spinal cord segments. Neurochemistry international 3 31783066
2016 Exploring novel candidate genes from the Mouse Genome Informatics database: Potential implications for avian migration research. Integrative zoology 3 27061206
2008 Cloning, expression and immunolocalization of alpha1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract. Molecular human reproduction 3 18204069
2025 Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization. Brain and behavior 2 40170563
2024 Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia. Actas espanolas de psiquiatria 2 38622006
2023 Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis. Cellular and molecular biology (Noisy-le-Grand, France) 2 37571902
2022 Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients. Biomedicines 2 35453646
2016 Left ventricle transcriptomic analysis reveals connective tissue accumulation associates with initial age-dependent decline in V̇o2peak from its lifetime apex. Physiological genomics 2 27913688
2015 Could α1-adrenoceptors and androgen receptors be modified by sexual maturation and testosterone in the rat testicular capsule? Life sciences 2 26388559
2025 Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca2+/Calcineurin/NFAT1-dependent anti-EndMT pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 1 40398181
2024 Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes. American journal of physiology. Endocrinology and metabolism 1 39046281
2024 Dissecting the association between blood pressure traits, hypertension, antihypertensive medications and epilepsy: A Mendelian randomization study. Epilepsy & behavior : E&B 1 39541744
2024 Revealing the molecular landscape of calcium oxalate renal calculi utilizing a tree shrew model: a transcriptomic analysis of the kidney. Urolithiasis 1 39546021
2023 L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α1B Receptor at the Second Transmembrane Interface. Biological & pharmaceutical bulletin 1 37394637
2018 Characterization of a β2 adrenergic receptor protein precursor in the European eel (Anguilla anguilla) and its tissue distribution across silvering. Marine environmental research 1 29576394
2026 Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration. Progress in neuro-psychopharmacology & biological psychiatry 0 41999833
2025 Autoimmune Antibodies in Orthostatic Intolerance Syndromes. Physiological research 0 40432440
2025 Osthol ameliorates obesity-associated lipid metabolic disorders by inhibiting ADRA1D-dependent Th17 cell differentiation. Scientific reports 0 41120583
2024 Patulin alters alpha-adrenergic receptor signalling and induces epigenetic modifications in the kidneys of C57BL/6 mice. Archives of toxicology 0 38806716
2024 Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine-Alpha-Adrenergic Receptor Signaling. bioRxiv : the preprint server for biology 0 38915622
2024 Chromogranin A Deficiency Attenuates Tauopathy by Altering Epinephrine-Alpha-Adrenergic Receptor Signaling. Research square 0 39149499
2023 Effects of Genetic Mutation Sites in ADR Genes on Modern Chickens Produced and Domesticated by Artificial Selection. Biology 0 36829448

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