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Showing TADA2A — ADA2A is a alias.

TADA2A

Transcriptional adapter 2-alpha · UniProt O75478

Length
443 aa
Mass
51.5 kDa
Annotated
2026-06-10
49 papers in source corpus 19 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TADA2A (hADA2/TADA2L) is the defining, nucleating subunit of the metazoan ATAC histone acetyltransferase complex, where it assembles with GCN5/PCAF, ADA3, and SGF29 to form the HAT module and stimulate GCN5-dependent acetylation (PMID:18838386, PMID:26468280, PMID:30559249). The TADA2A-GCN5 interaction is conserved from yeast and maps to a conserved GCN5 amino-terminal interface, and TADA2A itself carries a cryptic transcriptional activation domain (PMID:8552087). Within ATAC, TADA2A directs a histone substrate preference distinct from its SAGA paralog ADA2B: loss of ADA2a/TADA2A in Drosophila reduces nucleosomal histone H4K5/K12 acetylation while leaving H3K9/K14 (the ADA2b/SAGA marks) intact, and reconstituted human ATAC HAT modules enhance GCN5 acetylation of H3K14 (PMID:16135810, PMID:17030603, PMID:26468280). ATAC functions broadly in chromatin and transcriptional control — it is recruited to chromatin in a manner dependent on NURF remodeling, cooperates with other remodelers to stimulate nucleosome sliding, and contains a YEATS2-NC2beta module that contacts TBP to negatively regulate transcription (PMID:18084186, PMID:18838386, PMID:18327268). Beyond histones, ATAC/TADA2A acetylates non-histone substrates: ATAC localizes to the mitotic spindle and GCN5-mediated acetylation targets Cyclin A for degradation, with depletion causing centrosome amplification, spindle defects, and delayed mitotic progression (PMID:20562830). ATAC architecture depends on ATAC2/KAT14, whose loss disassembles the complex (PMID:18327268, PMID:19103755). TADA2A also participates in development and stem-cell fate, including germline functions and germline stem cell differentiation via cooperation with Set2/Msl3 (PMID:16135810, PMID:34878097), and is implicated in disease through binding the alpha-synuclein A53T mutant — which reduces histone H3 acetylation and correlates with reduced TADA2A in Parkinson's disease substantia nigra — and through recruitment of ATAC by TAZ/YAP oncogenic fusion proteins to reprogram transcription (PMID:34065515, PMID:33913810).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 Medium

    Established that the human ADA2 homolog physically partners with GCN5 and possesses intrinsic transcriptional activation capacity, defining TADA2A as a conserved coactivator-associated factor.

    Evidence Reciprocal yeast two-hybrid and transcriptional activation reporter assays in yeast and HeLa cells

    PMID:8552087

    Open questions at the time
    • Did not define the native complex containing the pair
    • Substrate specificity unresolved
  2. 1997 Medium

    Mapped the ADA2-GCN5 interaction to a conserved GCN5 amino terminus and showed coordinated genomic organization/expression of TADA2A and GCN5, hinting at functional pairing.

    Evidence Two-hybrid deletion mapping; FISH chromosomal mapping and Northern expression profiling

    PMID:8552087 PMID:9073520

    Open questions at the time
    • Did not establish whether co-regulation reflects shared function in vivo
  3. 2000 Medium

    Placed TADA2A in nuclear receptor coactivation by showing direct binding to thyroid hormone receptor and a requirement for hormone-dependent transcriptional activation.

    Evidence Yeast ada-mutant genetics, in vitro protein binding, and reporter assays with hTRbeta1/GRIP1/SRC-1

    PMID:10809234

    Open questions at the time
    • Demonstrated in yeast genetic context; mammalian in vivo relevance not tested
    • No chromatin readout
  4. 2006 High

    Established that ADA2a and ADA2b are functionally distinct paralogs by showing ADA2a loss reduces H4K5/K12 acetylation while leaving the H3K9/K14 marks of ADA2b intact, defining ADA2a's H4-specific GCN5 complex.

    Evidence Drosophila genetic null mutants with polytene chromosome immunostaining and dGcn5-dAda2a genetic interaction

    PMID:16135810 PMID:17030603

    Open questions at the time
    • Did not biochemically isolate the human complex
    • Direct enzymatic mechanism not reconstituted at this stage
  5. 2008 High

    Defined the subunit composition of the human and Drosophila ATAC complex containing TADA2A, identified it as a double-HAT complex, and showed it stimulates remodeler activity and contains a TBP-contacting repressive module.

    Evidence Biochemical purification with MS (MudPIT), co-IP, in vitro HAT and nucleosome sliding assays, transcriptional reporters

    PMID:18327268 PMID:18838386

    Open questions at the time
    • Roles of individual ATAC subunits in substrate selection not fully dissected
  6. 2008 High

    Identified ATAC2/KAT14 as the architectural subunit whose loss disassembles mammalian ATAC, indicating TADA2A function depends on complex integrity.

    Evidence Immunoprecipitation, RNAi, in vitro HAT assay, and Atac2 knockout mice

    PMID:19103755

    Open questions at the time
    • TADA2A's own contribution to complex assembly versus ATAC2 not separated here
  7. 2010 High

    Revealed a non-histone, mitotic function: ATAC localizes to the spindle and ATAC/GCN5-mediated acetylation targets Cyclin A for degradation, controlling mitotic progression.

    Evidence RNAi of Ada2a/Ada3, immunofluorescence, FACS cell-cycle analysis, in vitro acetylation of Cyclin A/Cdk2

    PMID:20562830

    Open questions at the time
    • Direct acetylation site on Cyclin A by TADA2A-containing module not pinpointed
    • Link to SIRT2 partially characterized
  8. 2015 High

    Reconstituted the human HAT module to show ADA2a (TADA2A) enhances GCN5 acetylation of H3K14, while confirming ADA2b exerts a stronger effect, refining the paralog division of labor.

    Evidence In vitro HAT assays with recombinant and endogenous HAT modules on peptide and full-length histone substrates

    PMID:26468280

    Open questions at the time
    • Structural basis for differential GCN5 stimulation not resolved
    • Non-histone substrate specificity within module not tested
  9. 2019 High

    Demonstrated that Ada2a nucleates ATAC assembly, formally establishing TADA2A as the defining subunit distinguishing ATAC from the ADA2b-nucleated SAGA/CHAT complexes.

    Evidence Affinity purification/MS and isoform-specific genetic analysis in Drosophila

    PMID:30559249

    Open questions at the time
    • Nucleation mechanism in mammalian cells not directly shown
  10. 2021 Medium

    Connected TADA2A to disease, identifying it as an alpha-synuclein A53T binding partner whose engagement reduces histone H3 acetylation, with reduced TADA2A in Parkinson's disease tissue.

    Evidence BioID proximity labeling, nuclear fractionation, histone H3 acetylation Western blots, mouse PFF injection model, human PD tissue

    PMID:34065515

    Open questions at the time
    • Causal contribution of the interaction to neurodegeneration not established
    • Whether ATAC complex integrity mediates the effect unclear
  11. 2021 Medium

    Implicated ATAC/TADA2A in oncogenic transcriptional reprogramming, showing TAZ-CAMTA1 and YAP-TFE3 fusions recruit ATAC subunits to co-drive a unique transcriptome.

    Evidence Proteomic AP-MS screen, genetic validation, and integrative ChIP-seq/RNA-seq

    PMID:33913810

    Open questions at the time
    • Direct TADA2A contribution versus other ATAC subunits not isolated
    • Mechanism via YEATS2/ZZZ3 rather than TADA2A binding directly
  12. 2022 Medium

    Extended ATAC/TADA2A function to stem-cell fate and stress responses, showing roles in germline stem cell differentiation and in MSH6-dependent alkylation damage response coupled to sterol biosynthesis.

    Evidence Drosophila genetic epistasis with Set2/Msl3 in oogenesis; co-IP, RNAi, and sterol biosynthesis assays for MSH6/MPTAC/ATAC axis

    PMID:34878097 PMID:35189552

    Open questions at the time
    • Direct acetylation targets in these pathways unidentified
    • TADA2A-specific requirement versus whole-complex requirement not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TADA2A structurally determines GCN5 substrate selection and how its non-histone acetylation and disease-associated interactions are regulated in mammalian cells remain unresolved.
  • No structural model of the human ATAC HAT module bound to substrate
  • Full repertoire of non-histone substrates of TADA2A-containing ATAC undefined
  • Mechanism linking TADA2A loss to Parkinson's pathology not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0042393 histone binding 3 GO:0098772 molecular function regulator activity 2 GO:0140096 catalytic activity, acting on a protein 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005694 chromosome 2 GO:0005634 nucleus 1
Pathway
R-HSA-4839726 Chromatin organization 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-1640170 Cell Cycle 1
Partners
AATFADA3ATAC2GCN5SGF29SNCATADA2B
Complex memberships
ATAC HAT module (GCN5-ADA2A-ADA3-SGF29)ATAC complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 Human ADA2 (hADA2/TADA2A) interacts with human GCN5 (hGCN5) in vivo as shown by yeast two-hybrid assay, and hGCN5 interacts with yeast ADA2, indicating conserved complex formation. hADA2 contains a cryptic activation domain, and GAL4-hADA2 activates transcription in HeLa cells; hADA2 or hGCN5 augments GAL4-VP16 activation. Yeast two-hybrid assay, transcriptional activation assays in yeast and HeLa cells Molecular and cellular biology Medium 8552087
1997 The region of yeast ADA2 that interacts with yGCN5 maps to the amino terminus, which is highly conserved in hADA2/TADA2A, establishing structural conservation of the ADA2-GCN5 interaction interface. Yeast two-hybrid mapping with deletion constructs Molecular and cellular biology Medium 8552087
1997 TADA2L (TADA2A) and GCN5L2 co-localize to chromosome 17q12-q21 and are expressed at relatively similar levels across all human tissues, suggesting coordinated regulation. Northern blot analysis, fluorescence in situ hybridization (FISH) Genomics Medium 9073520
2000 hADA2/TADA2A is required for T3/GRIP1 and SRC-1 coactivator-dependent transcriptional activation by human thyroid hormone receptor (hTRbeta1) in yeast. hTRbeta1 binds directly to hADA2 in vitro protein-protein interaction experiments, placing TADA2A in the nuclear receptor coactivation pathway. Yeast genetics (ada mutants), in vitro protein-protein interaction, transcriptional reporter assays Molecular endocrinology Medium 10809234
2005 Drosophila Ada2a null mutants are late-larval lethal and show defects in cell proliferation. Ada2a function is required in the female germ line. Ada2a null mutation does NOT reduce histone H3 K14 or H3 K9 acetylation (in contrast to Ada2b), establishing that ADA2a and ADA2b have distinct histone substrate specificities. Genetic null mutants, pole-cell transplantation germ-line mosaics, histone acetylation immunostaining Molecular and cellular biology High 16135810
2005 The Drosophila Ada2a gene shares overlapping regulatory/promoter regions with the Dtl (PIMT) gene and also produces RPB4 via alternative splicing, establishing a complex genomic architecture for Ada2a. Reporter gene fusions in tissue culture and transgenic animals, alternative splicing analysis Gene Medium 15777699
2005 TADA2A (TADA2L) shares a bidirectional promoter with ACACA in humans, mice, rats, and sheep; this shared promoter co-regulates transcripts for both genes in an asymmetric fashion, with RNA polymerase II concentration in the intergenic region reflecting transcript abundance differences. 5'-RACE, RNA polymerase II ChIP, Northern analysis across tissues Genomics Medium 15607423
2006 In Drosophila, loss of dAda2a results in reduced nucleosomal histone H4 acetylation at lysines 12 and 5, while H3 K9 and K14 acetylation (established by dAda2b-containing complexes) is unaffected. Genetic interaction between dGcn5 and dAda2a produces similar chromosome structural and developmental defects, placing dAda2a in an H4-specific GCN5-containing complex (ATAC). Genetic null mutants, immunostaining of polytene chromosomes, genetic interaction analysis Molecular and cellular biology High 17030603
2007 In Drosophila, mutations in Ada2a (ATAC component) induce decondensation of the male X chromosome similar to NURF mutants. Ada2a chromosome binding and histone H4-Lys12 acetylation are compromised in Iswi and Nurf301 mutants, indicating that NURF nucleosome remodeling is required for ATAC/Ada2a to access chromatin. Genetic epistasis, polytene chromosome immunostaining, transcript profiling EMBO reports Medium 18084186
2008 Human ATAC complex was purified and found to contain ADA2A (TADA2A), ADA3, GCN5 or PCAF, STAF36/WDR5, POLE3/CHRAC17, POLE4, TAK1/MAP3K7, MBIP, YEATS2, and NC2beta. The YEATS2-NC2beta histone fold module interacts with TBP and negatively regulates transcription when recruited to a promoter, establishing TADA2A as a core subunit of human ATAC distinct from STAGA. Biochemical purification (mass spectrometry), co-immunoprecipitation, transcriptional reporter assays The Journal of biological chemistry High 18838386
2008 The Drosophila ATAC complex, containing Ada2a, is a double HAT complex with Gcn5 and Atac2 (KAT14) as two acetyltransferases. ATAC stimulates nucleosome sliding by ISWI, SWI-SNF, and RSC remodeling complexes but does not itself exhibit nucleosome-remodeling activity. MudPIT mass spectrometry, in vitro HAT assays with recombinant Atac2, in vitro nucleosome sliding assays Nature structural & molecular biology High 18327268
2008 Mammalian ATAC complex contains GCN5, ATAC2, and ADA2A (TADA2A) among other subunits. ATAC2 depletion results in disassembly of the complex, showing that ATAC2 plays an architectural role in maintaining mammalian ATAC integrity—and consequently the functional complex containing TADA2A. Immunoprecipitation, RNAi depletion, in vitro HAT assay with recombinant ATAC2, Atac2 knockout mice Molecular and cellular biology High 19103755
2010 ATAC complex (containing Ada2a/TADA2A) localizes to the mitotic spindle. RNAi depletion of Ada2a or Ada3 causes centrosome multiplication, defective spindle and midbody formation, binucleated cells, delayed M/G1 transition, and hyperacetylation of histone H4K16 and alpha-tubulin. ATAC/Gcn5-mediated acetylation targets Cyclin A for degradation, which regulates SIRT2 deacetylase activity, establishing a non-histone substrate role for ATAC in mitotic progression. RNAi knockdown, immunofluorescence localization, cell cycle FACS analysis, in vitro acetylation assays of Cyclin A/Cdk2 The EMBO journal High 20562830
2015 The HAT module of human ATAC is composed of GCN5, ADA2a (TADA2A), ADA3, and SGF29. ADA2a-containing (ATAC) HAT module enhances GCN5 acetyltransferase activity, primarily acetylating histone H3K14. ADA2b (in SAGA) has a stronger influence on GCN5 activity than ADA2a. The lysine acetylation specificity of GCN5 on histone tails is not altered by incorporation into ATAC versus SAGA HAT modules. In vitro HAT assays with purified recombinant and endogenous HAT modules, histone tail peptides and full-length histones as substrates The Journal of biological chemistry High 26468280
2017 Che-1/AATF interacts with ADA2A (TADA2A) and ADA2B in human cells (co-immunoprecipitation) and in yeast two-hybrid assays. Domain mapping identified the regions of ADA2A and GCN5 required for these interactions. Co-immunoprecipitation, co-localization, yeast two-hybrid domain mapping PloS one Medium 29232376
2019 In Drosophila, Ada2a nucleates formation of the ATAC complex (distinct from SAGA which is nucleated by Ada2b). Only the Ada2b-PB isoform is in SAGA; Ada2b-PA forms the distinct CHAT complex. This establishes that Ada2a is the defining subunit of the ATAC complex. Affinity purification, mass spectrometry, genetic analysis of isoform-specific mutants Journal of cell science High 30559249
2021 Alpha-synuclein A53T mutant preferentially localizes to the nucleus and binds TADA2A, identified as a novel binding partner via BioID proximity labeling. Alpha-synuclein A53T significantly reduces histone H3 acetylation in SH-SY5Y cells and in mouse striatum/substantia nigra after alpha-syn preformed fibril injection. TADA2A levels are decreased in the substantia nigra of Parkinson's disease patients, linking the alpha-syn A53T-TADA2A interaction to neurotoxicity. BioID proximity labeling, nuclear fractionation/localization, Western blot for histone H3 acetylation, mouse stereotaxic injection model, human PD tissue analysis International journal of molecular sciences Medium 34065515
2021 TAZ-CAMTA1 and YAP-TFE3 oncogenic fusion proteins interact with YEATS2 and ZZZ3, components of the ATAC complex (which contains TADA2A/ADA2A), as identified by a combined proteomic/genetic screen. The fusion proteins drive a unique transcriptome by simultaneously hyperactivating TEAD-based transcription and modulating chromatin via interaction with ATAC. Proteomic screen (affinity purification/MS), genetic validation, integrative next-generation sequencing (ChIP-seq, RNA-seq) eLife Medium 33913810
2022 In Drosophila, the histone acetyltransferase complex Ada2a-containing (ATAC) cooperates with Msl3 (H3K36me3 reader) and Set2 to regulate germline stem cell (GSC) differentiation during oogenesis, establishing a role for ATAC in GSC fate transition. Genetic mutant analysis, epistasis, transcriptional profiling in Drosophila oogenesis Development Medium 34878097
2022 MSH6 stabilization in response to alkylation damage requires interactions with both MPTAC and the Ada2a-containing ATAC complex. MSH6 promotes sterol biosynthesis via the mevalonate pathway in a MPTAC- and ATAC-dependent manner, placing ATAC (and thus TADA2A) in an alkylation damage response-sterol biosynthesis pathway. Co-immunoprecipitation, RNAi knockdown, biochemical assays for sterol biosynthesis Redox biology Medium 35189552

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. The Journal of biological chemistry 176 18838386
1996 Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Molecular and cellular biology 161 8552087
2008 ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Nature structural & molecular biology 155 18327268
1997 Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Molecular and cellular biology 143 8972232
2008 The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Molecular and cellular biology 91 19103755
2010 The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. The EMBO journal 76 20562830
2005 The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions. Molecular and cellular biology 66 16135810
2014 Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation. PLoS pathogens 62 24391497
2021 TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. eLife 57 33913810
2006 The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation. Molecular and cellular biology 52 17030603
2004 Drosophila Ada2b is required for viability and normal histone H3 acetylation. Molecular and cellular biology 52 15340070
2020 CircRNA TADA2A relieves idiopathic pulmonary fibrosis by inhibiting proliferation and activation of fibroblasts. Cell death & disease 51 32694556
2020 CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis. Journal of experimental & clinical cancer research : CR 50 32799891
2000 GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor. Molecular endocrinology (Baltimore, Md.) 49 10809234
2015 Subunits of ADA-two-A-containing (ATAC) or Spt-Ada-Gcn5-acetyltrasferase (SAGA) Coactivator Complexes Enhance the Acetyltransferase Activity of GCN5. The Journal of biological chemistry 45 26468280
2021 Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis. Cell death & disease 43 34588429
2018 Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis. BMC genomics 35 29514634
2011 Prenatally diagnosed 17q12 microdeletion syndrome with a novel association with congenital diaphragmatic hernia. Fetal diagnosis and therapy 33 22178801
2007 The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization. EMBO reports 33 18084186
2023 Conserved and plant-specific histone acetyltransferase complexes cooperate to regulate gene transcription and plant development. Nature plants 31 36879016
2022 Msl3 promotes germline stem cell differentiation in female Drosophila. Development (Cambridge, England) 24 34878097
2021 α-Synuclein A53T Binds to Transcriptional Adapter 2-Alpha and Blocks Histone H3 Acetylation. International journal of molecular sciences 24 34065515
2005 Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes. Genomics 24 15607423
2024 Identification of candidate regulatory genes for intramuscular fatty acid composition in pigs by transcriptome analysis. Genetics, selection, evolution : GSE 20 38347496
2021 Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer. Oncology reports 19 34296306
2019 The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. Journal of cell science 19 30559249
2020 The Gcn5 complexes in Drosophila as a model for metazoa. Biochimica et biophysica acta. Gene regulatory mechanisms 18 32735945
2020 TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p. OncoTargets and therapy 18 33293831
2013 Oesophageal atresia with tracheoesophageal fistula and anal atresia in a patient with a de novo microduplication in 17q12. European journal of medical genetics 16 24239950
2018 The lysine acetyltransferase GCN5 contributes to human papillomavirus oncoprotein E7-induced cell proliferation via up-regulating E2F1. Journal of cellular and molecular medicine 15 30079588
2008 An adenosine A(2A) antagonist injected in the NTS reverses thermal prolongation of the LCR in decerebrate piglets. Respiratory physiology & neurobiology 12 18775519
2010 An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets. Experimental physiology 10 20418346
2017 Transcriptome Profiling Uncovers Potential Common Mechanisms in Fetal Trisomies 18 and 21. Omics : a journal of integrative biology 9 29049012
1997 The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. Genomics 9 9073520
2023 Integrative analysis of histone acetyltransferase KAT2A in human cancer. Cancer biomarkers : section A of Disease markers 7 38007639
2022 Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. International journal of molecular sciences 6 35887219
2005 Intimate relationship between the genes of two transcriptional coactivators, ADA2a and PIMT, of Drosophila. Gene 6 15777699
2017 Che1/AATF interacts with subunits of the histone acetyltransferase core module of SAGA complexes. PloS one 5 29232376
2024 Prenatal diagnosis and perinatal findings of 17q12 microdeletion encompassing HNF1B in a fetus with bilateral hyperechogenic kidneys on fetal ultrasound and mild renal abnormality after birth, and a review of the literature of prenatal diagnosis of 17q12 microdeletion. Taiwanese journal of obstetrics & gynecology 4 38216274
2022 MPTAC links alkylation damage signaling to sterol biosynthesis. Redox biology 4 35189552
2009 The dissociable RPB4 subunit of RNA Pol II has vital functions in Drosophila. Molecular genetics and genomics : MGG 4 19921261
2022 Beyond Moco Biosynthesis-Moonlighting Roles of MoaE and MOCS2. Molecules (Basel, Switzerland) 3 35744859
2012 Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle. Gene 2 23262334
2025 CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia. Human cell 1 40608154
2024 MBIP promotes ESCC metastasis by activating MAPK pathway. Cellular signalling 1 38199596
2026 Development and optimization of T-ARMS PCR assays for detection of lethal haplotypes of TADA2A, UR1B, and PORL1B in pigs in Vietnam. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 0 41572607
2025 PCR-RFLP assays to detect recessive lethal alleles in Landrace and Duroc pigs in Vietnam. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 0 40772539
2024 Further screening of SNP loci of eggshell translucency related genes and evaluation of genetic effects. Poultry science 0 39013295
2024 Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis. Cellular and molecular biology (Noisy-le-Grand, France) 0 39097891

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